JP2017532178A - 創傷被覆用具 - Google Patents
創傷被覆用具 Download PDFInfo
- Publication number
- JP2017532178A JP2017532178A JP2017540337A JP2017540337A JP2017532178A JP 2017532178 A JP2017532178 A JP 2017532178A JP 2017540337 A JP2017540337 A JP 2017540337A JP 2017540337 A JP2017540337 A JP 2017540337A JP 2017532178 A JP2017532178 A JP 2017532178A
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- JP
- Japan
- Prior art keywords
- fibroin
- wound dressing
- layer
- wound
- dressing device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Abstract
Description
PEOは、使用者の体内に放出される蚕の繭、医薬品、活性成分、及び/又は殺菌性物質の前処理及び処理の間には、決して使用されない。
図1〜図2Bを参照して、本発明の一態様を説明する。創傷被覆用具1は、吸収剤層4,及び前述した特徴をもつフィブロインのナノ繊維で製造された創傷接触層を備えている。フィブロイン層は、創傷7と接触している。フィブロインナノ繊維の層2の一部、通常は周辺部分は、使用者の皮膚3とも接触している。
a.純正フィブロインメッシュを、室温、穏やかな攪拌条件下で、CaCl2、及び蟻酸と接触させて、可溶性にする。
b.工程(a)で得た粘稠溶液を、適当な容器に注ぎ、放置して残留蟻酸を気化させる。
c.工程(b)のフィブロイン及びCaCl2の混合物を、CaCl2から精製して、フィブロインフィルムを得る。
d.工程(c)のフィルムを剥離し、放置乾燥させる。
e.フィルムを、穏やかな攪拌条件下、蟻酸で処理し、フィブロインとび蟻酸の溶液を、シリンジに移し、静電紡糸する。
2:フィブロインナノ繊維の層
3:皮膚
4:吸収剤層
5:フィルム裏打ち材
6:ポリマー層
7:創傷
Claims (23)
- 少なくとも1枚の絹フィブロインナノ繊維の層(2)を含む創傷被覆用具であって、
前記フィブロインナノ繊維の層(2)において、フィブロインは、ナノ繊維から製造されていること、前記フィブロインナノ繊維の層(2)は、10〜40g/m2の範囲の質量を有していること、及び前記用具は、更に、吸収剤層(4)を含んでいることを特徴とする創傷被覆用具。 - 前記フィブロインナノ繊維の層(2)は、900nm未満の平均繊維直径を有している、請求項1に記載の創傷被覆用具。
- 前記フィブロインナノ繊維の層(2)は、200〜800nmの範囲、好ましくは400〜700nmの範囲の平均繊維直径を有している、請求項1又は2に記載の創傷被覆用具。
- 前記フィブロインナノ繊維の層(2)は、静電紡糸層である、請求項1又は2に記載の創傷被覆用具。
- 前記フィブロインナノ繊維の層(2)は、医薬品、活性成分又は殺菌性物質を含まない、請求項1〜4のいずれか1項に記載の創傷被覆用具。
- 前記フィブロインナノ繊維の層(2)は、25〜35g/m2の範囲の質量を有している、請求項1〜5のいずれか1項に記載の創傷被覆用具。
- 前記フィブロインナノ繊維の層(2)は、200〜800nmの範囲の平均繊維直径を有している、請求項1〜6のいずれか1項に記載の創傷被覆用具。
- 前記吸収剤層(4)は、フィブロインの2つの層の間に配置されている、請求項1〜7のいずれか1項に記載の創傷被覆用具。
- 1枚のフィブロイン層及び1枚の吸収剤層(4)から製造された用具を折り畳むことによって製造された請求項8に記載の創傷被覆用具。
- 前記吸収剤層(4)は、ビスコース繊維、ポリエステル繊維、セルロース繊維、コットン繊維、発泡体、ゲル形成粒子、ゲル形成繊維、ガーゼ、及び液体吸収性能がある創傷被覆部材から選択される少なくとも1つの材料である、請求項1〜9のいずれか1項に記載の創傷被覆用具。
- 前記吸収剤層(4)は、ビスコース/ポリエステルの質量比70/30の混合物である、請求項9に記載の創傷被覆用具。
- 前記吸収剤層(4)は、更に、殺菌性物質を含んでいる、請求項1〜11のいずれか1項に記載の創傷被覆用具。
- さらに、前記創傷被覆用具の少なくとも一部を、使用者の皮膚(3)に接着する手段(5,6)を含む、請求項1〜12のいずれか1項に記載の創傷被覆用具。
- 900nm未満の平均繊維直径を有するナノ繊維で製造されたフィブロイン層であって、創傷(7)を治療する用具(1)内に細菌を封じ込める要素として使用されるフィブロイン層。
- 前記平均繊維直径は、400〜700nmの範囲にある、請求項13に記載のフィブロイン層。
- 前記フィブロイン層は、静電紡糸フィブロインである、請求項14または15に記載のフィブロイン層。
- 体液吸収剤として使用するための請求項1〜13のいずれか1項に記載の創傷被覆用具(1)。
- 創傷の治療のために使用される請求項1〜13のいずれか1項に記載の創傷被覆用具(1)。
- 負圧創傷治療(NPWT)に使用される、請求項1〜13のいずれか1項に記載の創傷被覆用具(1)。
- 創傷被覆用具を製造する方法であって;
a.純正フィブロインメッシュを、室温、穏やかな攪拌条件下で、CaCl2、及び蟻酸と接触させて、可溶性にすること;
b.工程(a)で得た粘稠溶液を、適当な容器に注ぎ、放置して残留蟻酸を気化させること;
c.工程(b)のフィブロイン及びCaCl2の混合物を、CaCl2から精製して、フィブロインフルムを得ること;
d.工程(c)のフィルムを剥離し、放置乾燥すること;
e.フィルムを、穏やかな攪拌条件下、蟻酸で処理し、フィブロインとび蟻酸の溶液を、シリンジに移し、静電紡糸することを含む創傷被覆用具を製造する方法。 - 請求項20の方法により製造された創傷被覆用具。
- 前記吸収剤層は、ビスコース繊維、ポリエステル繊維、セルロース繊維、コットン繊維、発泡体、ゲル形成粒子、ゲル形成繊維、ガーゼ、及び液体吸収性能がある創傷被覆部材から選択される、請求項21に記載の創傷被覆用具。
- 前記吸収剤は、ビスコース/ポリエステルの質量比70/30の混合物である、請求項21に記載の創傷被覆用具。
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EP14189451 | 2014-10-17 | ||
EP14189451.9 | 2014-10-17 | ||
PCT/IB2015/057965 WO2016059611A1 (en) | 2014-10-17 | 2015-10-16 | "device for wound dressing" |
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US (1) | US20170216478A1 (ja) |
EP (2) | EP3206725B1 (ja) |
JP (1) | JP2017532178A (ja) |
KR (1) | KR20170085504A (ja) |
CN (1) | CN107106722A (ja) |
AU (1) | AU2015331990A1 (ja) |
BR (1) | BR112017007849A2 (ja) |
CA (1) | CA2963454A1 (ja) |
ES (1) | ES2734730T3 (ja) |
IL (1) | IL251493A0 (ja) |
MX (1) | MX2017004844A (ja) |
PL (1) | PL3206725T3 (ja) |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021066078A1 (ja) * | 2019-09-30 | 2021-04-08 | Spiber株式会社 | 筋組織再生剤 |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109232464B (zh) | 2017-07-10 | 2022-11-15 | 上海新理念生物医药科技有限公司 | 噁二唑型连接子及其应用 |
IT201700091328A1 (it) * | 2017-08-07 | 2019-02-07 | Leonardino S R L | Matrice elettrofilata a base di proteine della seta, procedimento per la sua preparazione, manufatti che la comprendono e loro uso in terapia ed in cosmetica |
US20210236644A1 (en) | 2017-11-10 | 2021-08-05 | Cocoon Biotech Inc. | Ocular applications of silk-based products |
CN108939129A (zh) * | 2018-07-08 | 2018-12-07 | 东莞市联洲知识产权运营管理有限公司 | 一种聚吡咯/蚕丝蛋白晶体的制备方法及其制备的医用敷料 |
AU2020288624A1 (en) | 2019-06-04 | 2022-02-03 | Cocoon Biotech Inc. | Silk-based products, formulations, and methods of use |
CN110215350B (zh) * | 2019-06-06 | 2021-09-07 | 杭州贝高母婴用品有限公司 | 一种干爽、透气的纸尿裤及其生产工艺 |
US11311641B1 (en) | 2020-11-20 | 2022-04-26 | Mehrdad Mark Mofid | Scaffold wound dressing |
CN113813437B (zh) * | 2021-09-28 | 2022-07-01 | 振德医疗用品股份有限公司 | 基于细菌非特异性粘附的抗感染防黏连创面敷料 |
CN114631934A (zh) * | 2022-03-14 | 2022-06-17 | 中国人民解放军联勤保障部队第九二〇医院 | 一种可营造低氧微环境促急性创面早期愈合的敷料 |
CN115137557B (zh) * | 2022-07-12 | 2023-01-10 | 浙江理工大学 | 一种具有定向导液功能的纤维基敷料的制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009523591A (ja) * | 2006-01-24 | 2009-06-25 | アイダブリューエムティー インテレクチャル プロパティ ホールディングス(プロプライエタリー)リミテッド | 創傷被覆材 |
JP2012533354A (ja) * | 2009-07-14 | 2012-12-27 | タフツ ユニバーシティー/トラスティーズ オブ タフツ カレッジ | 創傷治癒のための電界紡糸絹材料システム |
CN103341209A (zh) * | 2013-07-08 | 2013-10-09 | 苏州大学 | 一种丝素蛋白纳米纤维膜及其制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100482189C (zh) * | 2005-09-07 | 2009-04-29 | 浙江大学 | 一种生物敷料及其制备方法 |
CN101736430B (zh) * | 2010-02-05 | 2012-07-04 | 东华大学 | 具有护肤功效的丝素蛋白纳米纤维的制备方法 |
SG188273A1 (en) * | 2010-08-30 | 2013-04-30 | Harvard College | A high strength chitin composite material and method of making |
EP2619356A4 (en) | 2010-09-22 | 2014-04-09 | Univ Virginia Commonwealth | PREPARATION RICH IN FIBROUS MATRICES BASED ON GROWTH FACTORS FOR TISSUE GENE, RELEASE OF GROWTH FACTORS AND HEALING |
EP2545943A1 (de) | 2011-07-12 | 2013-01-16 | Dr. Suwelack Skin & Health Care AG | Perforiertes, geschichtetes Wundbehandlungsmaterial |
EP3351665B1 (en) * | 2011-11-01 | 2020-06-03 | Brightwake Limited | Gelling wound dressings |
US9101508B2 (en) * | 2011-12-07 | 2015-08-11 | Esmaeil Mirzaei | Electro spun nanofibrous wound dressing and a method of synthesizing the same |
CN102560888B (zh) * | 2012-01-17 | 2014-08-13 | 东华大学 | 负载水溶性维生素e的丝素蛋白纳米纤维膜及其制备方法 |
CN103341214B (zh) * | 2013-07-08 | 2014-12-31 | 苏州大学 | 一种丝素蛋白膜及其制备方法 |
CN103446617A (zh) | 2013-08-28 | 2013-12-18 | 暨南大学 | 负载硫酸庆大霉素/明胶微球复合物的丝素蛋白支架及制备方法 |
-
2015
- 2015-10-16 AU AU2015331990A patent/AU2015331990A1/en not_active Abandoned
- 2015-10-16 BR BR112017007849A patent/BR112017007849A2/pt not_active Application Discontinuation
- 2015-10-16 ES ES15798194T patent/ES2734730T3/es active Active
- 2015-10-16 US US15/518,632 patent/US20170216478A1/en not_active Abandoned
- 2015-10-16 EP EP15798194.5A patent/EP3206725B1/en active Active
- 2015-10-16 EP EP19162289.3A patent/EP3517142A1/en not_active Withdrawn
- 2015-10-16 KR KR1020177012899A patent/KR20170085504A/ko unknown
- 2015-10-16 WO PCT/IB2015/057965 patent/WO2016059611A1/en active Application Filing
- 2015-10-16 CA CA2963454A patent/CA2963454A1/en not_active Abandoned
- 2015-10-16 CN CN201580068180.XA patent/CN107106722A/zh active Pending
- 2015-10-16 MX MX2017004844A patent/MX2017004844A/es unknown
- 2015-10-16 PL PL15798194T patent/PL3206725T3/pl unknown
- 2015-10-16 JP JP2017540337A patent/JP2017532178A/ja active Pending
- 2015-10-16 RU RU2017116964A patent/RU2017116964A/ru not_active Application Discontinuation
-
2017
- 2017-04-02 IL IL251493A patent/IL251493A0/en unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009523591A (ja) * | 2006-01-24 | 2009-06-25 | アイダブリューエムティー インテレクチャル プロパティ ホールディングス(プロプライエタリー)リミテッド | 創傷被覆材 |
JP2012533354A (ja) * | 2009-07-14 | 2012-12-27 | タフツ ユニバーシティー/トラスティーズ オブ タフツ カレッジ | 創傷治癒のための電界紡糸絹材料システム |
CN103341209A (zh) * | 2013-07-08 | 2013-10-09 | 苏州大学 | 一种丝素蛋白纳米纤维膜及其制备方法 |
Non-Patent Citations (1)
Title |
---|
KIM, SO HYN: "Silk Fibroin Nanofiber. Electrospinning, Properties, and Structure", POLYMER JOURNAL, vol. 35, no. 2, JPN7019002818, 1 January 2003 (2003-01-01), pages 185 - 190, XP055239412, ISSN: 0004248641, DOI: 10.1295/polymj.35.185 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021066078A1 (ja) * | 2019-09-30 | 2021-04-08 | Spiber株式会社 | 筋組織再生剤 |
CN114555108A (zh) * | 2019-09-30 | 2022-05-27 | 丝芭博株式会社 | 肌肉组织再生剂 |
Also Published As
Publication number | Publication date |
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EP3517142A1 (en) | 2019-07-31 |
EP3206725A1 (en) | 2017-08-23 |
WO2016059611A1 (en) | 2016-04-21 |
PL3206725T3 (pl) | 2019-09-30 |
ES2734730T3 (es) | 2019-12-11 |
AU2015331990A1 (en) | 2017-05-04 |
US20170216478A1 (en) | 2017-08-03 |
RU2017116964A3 (ja) | 2019-04-23 |
CN107106722A (zh) | 2017-08-29 |
BR112017007849A2 (pt) | 2018-01-16 |
CA2963454A1 (en) | 2016-04-21 |
MX2017004844A (es) | 2018-01-24 |
IL251493A0 (en) | 2017-05-29 |
EP3206725B1 (en) | 2019-04-17 |
KR20170085504A (ko) | 2017-07-24 |
RU2017116964A (ru) | 2018-11-19 |
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