JP2017513625A - 血液酸素供給器 - Google Patents
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Abstract
Description
本願は、2014年4月23日に出願の「血液酸素供給器」と題した米国仮特許出願第61/983,314号の優先権を主張し、該出願はその全体において参照により本明細書に組み入れられる。
酸素供給器は、損傷したかまたは疾患のある肺によって行われる酸素化を補うための肺補助装置として使用することができる。血液酸素供給器のための標準的な構成は、中空繊維ネットワークに基づく。中空繊維ネットワークは、酸素供給器を流れる血液に損傷をもたらす傾向がある高濃度の抗凝血剤を必要とする場合がある。中空繊維酸素供給器は、比較的長い血液流路、滞留時間、および多くの血液導入量(blood prime volume)を有する場合もある。
開示の一局面によれば、酸素供給器は、第一の複数の気体通路および第一の複数の流体通路を画定する第一高分子層、第二の複数の気体通路および第二の複数の流体通路を画定する第二高分子層を含む。第二の複数の気体通路のそれぞれは、第一の複数の流体通路の1つと重なる。第二の複数の流体通路のそれぞれは、第一の複数の気体通路の1つと重なる。酸素供給器は、第三の複数の気体通路および第三の複数の流体通路を画定する第三高分子層も含む。第三の複数の気体通路のそれぞれは、第二の複数の流体通路の1つと重なり、第三の複数の流体通路のそれぞれは、第二の複数の気体通路の1つと重なる。第二高分子層は、複数の気体ビアも画定する。複数の気体ビアのそれぞれは、第一の複数の気体通路の1つを第三の複数の気体通路の1つに結合する。
上で紹介しかつ下により詳細に述べる様々な概念は、記載の概念が任意の特定の実施形態の様式に限定されるものではないので、種々のやり方のいずれで実施されてもよい。具体的な実施形態および用途の例は、主に例示を目的として提供される。
Claims (28)
- 第一の複数の気体通路および第一の複数の流体通路を含む第一高分子層と;
第二の複数の気体通路のそれぞれが、第一の複数の流体通路の1つと重なり、第二の複数の流体通路のそれぞれが、第一の複数の気体通路の1つと重なる、第二の複数の気体通路および第二の複数の流体通路を含む第二高分子層と;
第三の複数の気体通路のそれぞれが、第二の複数の流体通路の1つと重なり、第三の複数の流体通路のそれぞれが、第二の複数の気体通路の1つと重なる、第三の複数の気体通路および第三の複数の流体通路を含む第三高分子層と;
複数の気体ビアのそれぞれが、第一の複数の気体通路の1つを第三の複数の気体通路の1つに結合する、第二高分子層に画定された複数の気体ビアと
を含む、酸素供給器。 - 第一高分子層に画定された第二の複数の気体ビアおよび第三高分子層に画定された第三の複数の気体ビアをさらに含む、請求項1記載の酸素供給器。
- 第一の複数の気体通路および第三の複数の気体通路が、第一気体流ネットワークを規定し、第二の複数の気体通路が、第二気体流ネットワークを規定する、請求項1記載の酸素供給器。
- 第二の複数の流体通路のそれぞれが、第一の複数の気体通路の1つと実質的に垂直に一列に並び、第三の複数の気体通路のそれぞれが、第二の複数の流体通路の1つと実質的に垂直に一列に並び、第三の複数の流体通路のそれぞれが、第二の複数の気体通路の1つと実質的に垂直に一列に並ぶ、請求項1記載の酸素供給器。
- 第一の複数の気体通路および第一の複数の流体通路が、交互パターンで配置され、第二の複数の気体通路および第二の複数の流体通路が、交互パターンで配置され、第三の複数の気体通路および第三の複数の流体通路が、交互パターンで配置された、請求項1記載の酸素供給器。
- 交互パターンが、気体通路および流体通路が厳密に交互であることを含む、請求項5記載の酸素供給器。
- 第一、第二、および第三高分子層を収容する圧力容器をさらに含む、請求項1記載の酸素供給器。
- 第一、第二、および第三の複数の気体通路への流入口が、圧力容器内の周囲環境に開口している、請求項7記載の酸素供給器。
- 第一の複数の気体通路および第一の複数の流体通路が、非対称の通路配列で構成され、第二の複数の気体通路および第二の複数の流体通路が、非対称の通路配置で構成されている、請求項1記載の酸素供給器。
- 第二および第三高分子層がそれぞれ、第一高分子層の複製である、請求項1記載の酸素供給器。
- 第二高分子層が、第一および第三高分子層に対して180度回転している、請求項10記載の酸素供給器。
- 第一、第二、および第三の複数の気体通路の各通路が、閉端部を含む、請求項1記載の酸素供給器。
- 複数の気体ビアのそれぞれが、第二高分子層の複数の流体通路のうちの2つの間に位置している、請求項1記載の酸素供給器。
- 複数の気体ビアのそれぞれが、第二高分子層における複数の流体通路のうちの1つの長軸と一列に並ぶ、請求項1記載の酸素供給器。
- 第一、第二、および第三の複数の流体通路の深さが、約40μm〜約250μmである、請求項1記載の酸素供給器。
- 第一、第二、および第三高分子層がそれぞれ、ポリ(ジメチルシロキサン)を含む、請求項1記載の酸素供給器。
- 第一、第二、および第三高分子層がそれぞれ、約1×10-6mL/s/cm2/cm Hgより大きい気体透過度を有する、請求項1記載の酸素供給器。
- 請求項1記載の酸素供給器を提供する工程、
酸素供給器を収容する圧力容器に酸素を導入する工程、
少なくとも部分的に脱酸素化された血液を酸素供給器に導入する工程、および
少なくとも部分的に酸素化された血液を酸素供給器から受け取る工程
を含む、血液を酸素化する方法。 - 導入した酸素で約1.0atm〜約2.5atmの圧力まで圧力容器を加圧する工程をさらに含む、請求項18記載の方法。
- 導入した酸素で約2.0atm〜約3.0atmの圧力まで圧力容器を加圧する工程をさらに含む、請求項18記載の方法。
- 少なくとも部分的に脱酸素化された血液を約500mL/分〜約7L/分の速度で酸素供給器に導入する工程をさらに含む、請求項18記載の方法。
- 第一高分子層に第一の複数の気体通路および第一の複数の流体通路を画定する工程、
第二高分子層に第二の複数の気体通路、第二の複数の流体通路、および複数の気体ビアを画定する工程、
第三高分子層に第三の複数の気体通路および第三の複数の流体通路を画定する工程、
第一および第三高分子層に対して第二高分子層を回転させる工程、
複数の気体ビアのそれぞれを、第一の複数の気体通路のそれぞれの流入口および第三の複数の気体通路のそれぞれの流入口と一列に並べる工程、
第一高分子層を第二高分子層に結合する工程、ならびに
第三高分子層を第二高分子層に結合する工程
を含む、酸素供給器を製造する方法。 - 第一高分子層を第二高分子層の第一面に結合する工程、および
第三高分子層を第二高分子層の第二面に結合する工程
をさらに含む、請求項22記載の方法。 - 第一および第三高分子層に対して第二高分子層を約180度回転させる工程をさらに含む、請求項22記載の方法。
- 第二および第三高分子層がそれぞれ、第一高分子層の複製である、請求項22記載の方法。
- 第一の複数の気体通路を第二の複数の流体通路と一列に並べる工程、および
第一の複数の流体通路を第二の複数の気体通路と一列に並べる工程
をさらに含む、請求項22記載の方法。 - 第一高分子層に第二の複数の気体ビアを画定する工程、および
第三高分子層に第三の複数の気体ビアを画定する工程
をさらに含む、請求項22記載の方法。 - 第一高分子層および第三高分子層が、第二高分子層に、浸透性接着剤、ホットメルト接着剤、プラズマボンディング、超音波溶接、摩擦溶接、またはレーザー溶接により結合される、請求項22記載の方法。
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US201461983314P | 2014-04-23 | 2014-04-23 | |
US61/983,314 | 2014-04-23 | ||
PCT/US2015/027321 WO2015164618A1 (en) | 2014-04-23 | 2015-04-23 | Blood oxygenator |
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EP (1) | EP3134145B1 (ja) |
JP (1) | JP2017513625A (ja) |
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WO (1) | WO2015164618A1 (ja) |
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US20210015844A1 (en) | 2018-03-14 | 2021-01-21 | Beacon Medcare (Hk) Limited | Composition for purification of biofluids |
US11988471B2 (en) * | 2021-03-27 | 2024-05-21 | Massachusetts Institute Of Technology | Devices and methods for fabrication of components of a multiscale porous high-temperature heat exchanger |
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US20150306296A1 (en) | 2015-10-29 |
US9717835B2 (en) | 2017-08-01 |
EP3134145A1 (en) | 2017-03-01 |
ES2743476T3 (es) | 2020-02-19 |
EP3134145B1 (en) | 2019-06-12 |
WO2015164618A1 (en) | 2015-10-29 |
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