JP2017214307A - Composition for oral cavity - Google Patents
Composition for oral cavity Download PDFInfo
- Publication number
- JP2017214307A JP2017214307A JP2016108048A JP2016108048A JP2017214307A JP 2017214307 A JP2017214307 A JP 2017214307A JP 2016108048 A JP2016108048 A JP 2016108048A JP 2016108048 A JP2016108048 A JP 2016108048A JP 2017214307 A JP2017214307 A JP 2017214307A
- Authority
- JP
- Japan
- Prior art keywords
- mass
- composition
- component
- less
- oral cavity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 124
- 210000000214 mouth Anatomy 0.000 title claims abstract description 51
- 229910052751 metal Inorganic materials 0.000 claims abstract description 38
- 239000002184 metal Substances 0.000 claims abstract description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 13
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims abstract description 13
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims abstract description 13
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229910052782 aluminium Inorganic materials 0.000 claims abstract description 13
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000011575 calcium Substances 0.000 claims abstract description 13
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 13
- 239000011777 magnesium Substances 0.000 claims abstract description 13
- 229910052749 magnesium Inorganic materials 0.000 claims abstract description 13
- 229910052718 tin Inorganic materials 0.000 claims abstract description 13
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 13
- 239000011701 zinc Substances 0.000 claims abstract description 13
- 150000002739 metals Chemical class 0.000 claims abstract description 12
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical class C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 claims abstract description 8
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 50
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 39
- 239000010949 copper Substances 0.000 claims description 38
- 229910052802 copper Inorganic materials 0.000 claims description 38
- JVOGSHDZLOJKKR-MXFMKSRJSA-I [Na+].[Na+].[Na+].[Mg++].CCc1c(C)c2cc3[n-]c(c(C)c3C=C)c(C)c3nc(C[C@H]3CCC([O-])=O)c(CC([O-])=O)c3[n-]c(cc1n2)c(C)c3C([O-])=O Chemical compound [Na+].[Na+].[Na+].[Mg++].CCc1c(C)c2cc3[n-]c(c(C)c3C=C)c(C)c3nc(C[C@H]3CCC([O-])=O)c(CC([O-])=O)c3[n-]c(cc1n2)c(C)c3C([O-])=O JVOGSHDZLOJKKR-MXFMKSRJSA-I 0.000 claims description 29
- 229910052742 iron Inorganic materials 0.000 claims description 27
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 22
- 229910052731 fluorine Inorganic materials 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 19
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 18
- 125000004429 atom Chemical group 0.000 claims description 13
- 239000005749 Copper compound Substances 0.000 claims description 11
- 150000001875 compounds Chemical class 0.000 claims description 11
- 150000001880 copper compounds Chemical class 0.000 claims description 11
- 125000001153 fluoro group Chemical group F* 0.000 claims description 11
- 239000011775 sodium fluoride Substances 0.000 claims description 9
- 235000013024 sodium fluoride Nutrition 0.000 claims description 9
- 238000006243 chemical reaction Methods 0.000 claims description 7
- 150000002506 iron compounds Chemical class 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- -1 chlorophyll compound Chemical class 0.000 abstract description 15
- 229930002875 chlorophyll Natural products 0.000 abstract description 3
- 235000019804 chlorophyll Nutrition 0.000 abstract description 3
- HWDGVJUIHRPKFR-UHFFFAOYSA-I copper;trisodium;18-(2-carboxylatoethyl)-20-(carboxylatomethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18-dihydroporphyrin-21,23-diide-2-carboxylate Chemical compound [Na+].[Na+].[Na+].[Cu+2].N1=C(C(CC([O-])=O)=C2C(C(C)C(C=C3C(=C(C=C)C(=C4)[N-]3)C)=N2)CCC([O-])=O)C(=C([O-])[O-])C(C)=C1C=C1C(CC)=C(C)C4=N1 HWDGVJUIHRPKFR-UHFFFAOYSA-I 0.000 abstract 2
- OGMQNMUHVLRDRT-UHFFFAOYSA-J disodium;3-[20-(carboxylatomethyl)-18-(dioxidomethylidene)-8-ethenyl-13-ethyl-3,7,12,17-tetramethyl-2,3-dihydroporphyrin-23-id-2-yl]propanoate;hydron;iron(2+) Chemical compound [H+].[Na+].[Na+].[Fe+2].C1=C([N-]2)C(CC)=C(C)C2=CC(C(=C2C)C=C)=NC2=CC(C(C2CCC([O-])=O)C)=NC2=C(CC([O-])=O)C2=NC1=C(C)C2=C([O-])[O-] OGMQNMUHVLRDRT-UHFFFAOYSA-J 0.000 abstract 2
- 229940079841 sodium copper chlorophyllin Drugs 0.000 abstract 2
- 235000013758 sodium copper chlorophyllin Nutrition 0.000 abstract 2
- 230000000694 effects Effects 0.000 description 30
- 238000002845 discoloration Methods 0.000 description 19
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
- 239000000551 dentifrice Substances 0.000 description 13
- 239000007788 liquid Substances 0.000 description 12
- 239000011737 fluorine Substances 0.000 description 10
- 239000000606 toothpaste Substances 0.000 description 10
- 229940034610 toothpaste Drugs 0.000 description 10
- 238000000034 method Methods 0.000 description 9
- 230000002265 prevention Effects 0.000 description 9
- 206010006326 Breath odour Diseases 0.000 description 7
- 238000005259 measurement Methods 0.000 description 7
- 238000003860 storage Methods 0.000 description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 230000001747 exhibiting effect Effects 0.000 description 6
- 208000007565 gingivitis Diseases 0.000 description 6
- 239000003002 pH adjusting agent Substances 0.000 description 6
- 239000002244 precipitate Substances 0.000 description 6
- 239000013074 reference sample Substances 0.000 description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 5
- 239000011230 binding agent Substances 0.000 description 5
- 230000003405 preventing effect Effects 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000000523 sample Substances 0.000 description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000000600 sorbitol Substances 0.000 description 4
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 230000003139 buffering effect Effects 0.000 description 3
- 150000001879 copper Chemical class 0.000 description 3
- 229910000365 copper sulfate Inorganic materials 0.000 description 3
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 229920000591 gum Polymers 0.000 description 3
- 229910000029 sodium carbonate Inorganic materials 0.000 description 3
- 235000017550 sodium carbonate Nutrition 0.000 description 3
- 230000001629 suppression Effects 0.000 description 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 2
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical compound [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 239000000679 carrageenan Substances 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- 229940113118 carrageenan Drugs 0.000 description 2
- 235000015165 citric acid Nutrition 0.000 description 2
- 238000004040 coloring Methods 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- YEOCHZFPBYUXMC-UHFFFAOYSA-L copper benzoate Chemical compound [Cu+2].[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1 YEOCHZFPBYUXMC-UHFFFAOYSA-L 0.000 description 2
- 229940108925 copper gluconate Drugs 0.000 description 2
- 238000004993 emission spectroscopy Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000001630 malic acid Substances 0.000 description 2
- 235000011090 malic acid Nutrition 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000001139 pH measurement Methods 0.000 description 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 2
- 235000002949 phytic acid Nutrition 0.000 description 2
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- TYFQFVWCELRYAO-UHFFFAOYSA-N suberic acid Chemical compound OC(=O)CCCCCCC(O)=O TYFQFVWCELRYAO-UHFFFAOYSA-N 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- YNVZDODIHZTHOZ-UHFFFAOYSA-K 2-hydroxypropanoate;iron(3+) Chemical compound [Fe+3].CC(O)C([O-])=O.CC(O)C([O-])=O.CC(O)C([O-])=O YNVZDODIHZTHOZ-UHFFFAOYSA-K 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- DDFHBQSCUXNBSA-UHFFFAOYSA-N 5-(5-carboxythiophen-2-yl)thiophene-2-carboxylic acid Chemical compound S1C(C(=O)O)=CC=C1C1=CC=C(C(O)=O)S1 DDFHBQSCUXNBSA-UHFFFAOYSA-N 0.000 description 1
- PVXPPJIGRGXGCY-DJHAAKORSA-N 6-O-alpha-D-glucopyranosyl-alpha-D-fructofuranose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@](O)(CO)O1 PVXPPJIGRGXGCY-DJHAAKORSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- MBMLMWLHJBBADN-UHFFFAOYSA-N Ferrous sulfide Chemical compound [Fe]=S MBMLMWLHJBBADN-UHFFFAOYSA-N 0.000 description 1
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- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
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- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
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- 239000009223 Psyllium Substances 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
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- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
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- GOKIPOOTKLLKDI-UHFFFAOYSA-N acetic acid;iron Chemical compound [Fe].CC(O)=O.CC(O)=O.CC(O)=O GOKIPOOTKLLKDI-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 229940064004 antiseptic throat preparations Drugs 0.000 description 1
- 239000000305 astragalus gummifer gum Substances 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- ODWXUNBKCRECNW-UHFFFAOYSA-M bromocopper(1+) Chemical compound Br[Cu+] ODWXUNBKCRECNW-UHFFFAOYSA-M 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 1
- 229910001634 calcium fluoride Inorganic materials 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 229940099898 chlorophyllin Drugs 0.000 description 1
- 235000019805 chlorophyllin Nutrition 0.000 description 1
- KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000008139 complexing agent Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 229910001431 copper ion Inorganic materials 0.000 description 1
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 description 1
- XTVVROIMIGLXTD-UHFFFAOYSA-N copper(II) nitrate Chemical compound [Cu+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O XTVVROIMIGLXTD-UHFFFAOYSA-N 0.000 description 1
- CMRVDFLZXRTMTH-UHFFFAOYSA-L copper;2-carboxyphenolate Chemical compound [Cu+2].OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O CMRVDFLZXRTMTH-UHFFFAOYSA-L 0.000 description 1
- LZJJVTQGPPWQFS-UHFFFAOYSA-L copper;propanoate Chemical compound [Cu+2].CCC([O-])=O.CCC([O-])=O LZJJVTQGPPWQFS-UHFFFAOYSA-L 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- CEYULKASIQJZGP-UHFFFAOYSA-L disodium;2-(carboxymethyl)-2-hydroxybutanedioate Chemical compound [Na+].[Na+].[O-]C(=O)CC(O)(C(=O)O)CC([O-])=O CEYULKASIQJZGP-UHFFFAOYSA-L 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 238000006266 etherification reaction Methods 0.000 description 1
- 150000004673 fluoride salts Chemical class 0.000 description 1
- 150000002222 fluorine compounds Chemical class 0.000 description 1
- DWYMPOCYEZONEA-UHFFFAOYSA-N fluorophosphoric acid Chemical compound OP(O)(F)=O DWYMPOCYEZONEA-UHFFFAOYSA-N 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 235000010492 gellan gum Nutrition 0.000 description 1
- 239000000216 gellan gum Substances 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 description 1
- OVYSUCIJMISHSX-UHFFFAOYSA-N hexan-1-amine;hydrofluoride Chemical compound F.CCCCCCN OVYSUCIJMISHSX-UHFFFAOYSA-N 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- FBAFATDZDUQKNH-UHFFFAOYSA-M iron chloride Chemical compound [Cl-].[Fe] FBAFATDZDUQKNH-UHFFFAOYSA-M 0.000 description 1
- 235000014413 iron hydroxide Nutrition 0.000 description 1
- 229910000398 iron phosphate Inorganic materials 0.000 description 1
- MVFCKEFYUDZOCX-UHFFFAOYSA-N iron(2+);dinitrate Chemical compound [Fe+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O MVFCKEFYUDZOCX-UHFFFAOYSA-N 0.000 description 1
- DCYOBGZUOMKFPA-UHFFFAOYSA-N iron(2+);iron(3+);octadecacyanide Chemical compound [Fe+2].[Fe+2].[Fe+2].[Fe+3].[Fe+3].[Fe+3].[Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] DCYOBGZUOMKFPA-UHFFFAOYSA-N 0.000 description 1
- WBJZTOZJJYAKHQ-UHFFFAOYSA-K iron(3+) phosphate Chemical compound [Fe+3].[O-]P([O-])([O-])=O WBJZTOZJJYAKHQ-UHFFFAOYSA-K 0.000 description 1
- NPFOYSMITVOQOS-UHFFFAOYSA-K iron(III) citrate Chemical compound [Fe+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NPFOYSMITVOQOS-UHFFFAOYSA-K 0.000 description 1
- GYCHYNMREWYSKH-UHFFFAOYSA-L iron(ii) bromide Chemical compound [Fe+2].[Br-].[Br-] GYCHYNMREWYSKH-UHFFFAOYSA-L 0.000 description 1
- NCNCGGDMXMBVIA-UHFFFAOYSA-L iron(ii) hydroxide Chemical compound [OH-].[OH-].[Fe+2] NCNCGGDMXMBVIA-UHFFFAOYSA-L 0.000 description 1
- BQZGVMWPHXIKEQ-UHFFFAOYSA-L iron(ii) iodide Chemical compound [Fe+2].[I-].[I-] BQZGVMWPHXIKEQ-UHFFFAOYSA-L 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 229910001512 metal fluoride Inorganic materials 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 235000019656 metallic taste Nutrition 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 239000000467 phytic acid Substances 0.000 description 1
- 229940068041 phytic acid Drugs 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000137 polyphosphoric acid Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229940070687 psyllium Drugs 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 229910000031 sodium sesquicarbonate Inorganic materials 0.000 description 1
- 235000018341 sodium sesquicarbonate Nutrition 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- WCTAGTRAWPDFQO-UHFFFAOYSA-K trisodium;hydrogen carbonate;carbonate Chemical compound [Na+].[Na+].[Na+].OC([O-])=O.[O-]C([O-])=O WCTAGTRAWPDFQO-UHFFFAOYSA-K 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
本発明は、口腔用組成物に関する。 The present invention relates to an oral composition.
口腔用組成物には、口臭防止成分や抗菌成分、抗炎症成分、香味付与成分等、所望の作用をもたらす種々の有効成分が配合されており、銅クロロフィリンナトリウム等の各種銅化合物も、歯肉炎の予防効果や口臭予防効果を発揮し得る成分として知られている。 The oral composition contains various active ingredients that provide desired effects such as bad breath prevention components, antibacterial components, anti-inflammatory components, and flavor-imparting components, and various copper compounds such as copper chlorophyllin sodium are also used for gingivitis. It is known as a component capable of exhibiting a preventive effect and a bad breath preventive effect.
例えば、特許文献１には、硫酸銅やハロゲン化銅のような銅化合物、重炭酸塩及び錯化剤を含む口腔用組成物が開示されており、不溶性物質の沈殿を回避して、抗バクテリア効果の強化を図っている。また、特許文献２には、グルコン酸銅や硫酸銅、銅クロロフィリンナトリウム等の銅化合物と、縮合リン酸塩や炭酸水素塩、及びアミノ酸等とを配合した歯磨組成物が開示されており、清掃効果を高めつつ、金属味の発現を抑制して使用感の改善を試みている。 For example, Patent Document 1 discloses an oral composition containing a copper compound such as copper sulfate or copper halide, a bicarbonate, and a complexing agent. We are trying to strengthen the effect. Patent Document 2 discloses a dentifrice composition containing a copper compound such as copper gluconate, copper sulfate, and copper chlorophyllin sodium, and a condensed phosphate, hydrogen carbonate, amino acid, and the like. While improving the effect, it attempts to improve the feeling of use by suppressing the expression of metallic taste.
こうした銅化合物のなかでも銅クロロフィリンナトリウムは、歯肉炎予防効果や口臭予防効果をもたらす成分であって、安定性が保たれた環境下であれば、組成物が彩度の高い深緑色にやや着色することでも知られている。 Among these copper compounds, copper chlorophyllin sodium is a component that provides a gingivitis prevention effect and a bad breath prevention effect, and in a stable environment, the composition is slightly colored deep green with high saturation. Also known to do.
その一方、特に銅クロロフィリンナトリウムは、安定性が低下するにつれて褐色へと変色してしまうため、組成物の美観も損なわれるおそれもあるという、特有の性質を有している。 On the other hand, copper chlorophyllin sodium, in particular, has a unique property that the aesthetic appearance of the composition may be impaired because it turns brown as the stability decreases.
しかしながら、上記特許文献１においては、もっぱら銅化合物の生物学的利用能に着目するのみで、クロロフィル化合物を用いた具体例はなく、また特許文献２においては、銅化合物として銅クロロフィリンナトリウムを具体例として示されてはいるものの、不溶な沈殿物が生じ得る炭酸カルシウムを併用するにすぎず、いずれの文献も銅クロロフィリンナトリウム等のクロロフィル化合物特有の性質を加味しつつ、その安定性を高めようとするものではない。そのため、これらクロロフィル化合物が本来有する歯肉炎の予防効果や口臭予防効果を充分に発揮させるには、さらなる検討を要する状況にある。 However, in the above-mentioned patent document 1, only focusing on the bioavailability of the copper compound, there is no specific example using the chlorophyll compound, and in patent document 2, a specific example is copper chlorophyllin sodium as the copper compound. Although it is shown as, it is only used in combination with calcium carbonate that can cause insoluble precipitates, and both literatures try to improve the stability while taking into account the properties peculiar to chlorophyll compounds such as copper chlorophyllin sodium. Not what you want. Therefore, in order to fully exhibit the gingivitis prevention effect and the halitosis prevention effect which these chlorophyll compounds originally have, it is in the situation which requires further examination.
したがって、本発明は、銅クロロフィリンナトリウムや鉄クロロフィリンナトリウムの安定性を高めた口腔用組成物に関する。 Therefore, this invention relates to the composition for oral cavity which improved the stability of copper chlorophyllin sodium or iron chlorophyllin sodium.
そこで本発明者は、種々検討したところ、特定量の水が存在するなか、銅クロロフィリンナトリウム及び鉄クロロフィリンナトリウムから選ばれる１種以上のクロロフィリン化合物を特定量で含有しつつ、ｐＨを特定領域内とし、かつ特定の多価金属又はその塩の量を制限することで、銅クロロフィリンナトリウムの安定性に優れた口腔用組成物が得られることを見出した。 Therefore, the present inventor has made various studies, and in the presence of a specific amount of water, while containing a specific amount of one or more chlorophyllin compounds selected from copper chlorophyllin sodium and iron chlorophyllin sodium, the pH is set within a specific range. And it discovered that the composition for oral cavity excellent in stability of copper chlorophyllin sodium was obtained by restrict | limiting the quantity of a specific polyvalent metal or its salt.
すなわち、本発明は、次の成分（Ａ）、並びに（Ｂ）：
（Ａ）銅クロロフィリンナトリウム、及び鉄クロロフィリンナトリウムから選ばれる１種以上のクロロフィル化合物 ０．００１質量％以上０．５質量％以下、並びに
（Ｂ）水 １０質量％以上９０質量％以下
を含有し、２５℃におけるｐＨが７を超え１２以下であり、かつ
成分（Ａ）以外の銅、鉄、カルシウム、マグネシウム、アルミニウム、亜鉛、及び錫から選ばれる１種又は２種以上の多価金属又はその塩の含有量が、金属原子換算量で０．０２質量％以下である口腔用組成物に関する。
また、本発明は、次の成分（Ａ）、並びに（Ｂ）：
（Ａ）銅クロロフィリンナトリウム及び鉄クロロフィリンナトリウムから選ばれる１種以上のクロロフィル化合物 ０．００１質量％以上０．５質量％以下、並びに
（Ｂ）水 １０質量％以上９０質量％以下
を配合する工程（Ｉ）、
成分（Ａ）以外の銅、鉄、カルシウム、マグネシウム、アルミニウム、亜鉛、及び錫から選ばれる１種又は２種以上の多価金属又はその塩の含有量が、金属原子換算で０．０２質量％以下となるように調整する工程（II）、並びに
２５℃におけるｐＨを７より大きく１２以下に調整する工程（III）
を備える口腔用組成物の製造方法に関する。
That is, the present invention includes the following components (A) and (B):
(A) One or more chlorophyll compounds selected from copper chlorophyllin sodium and iron chlorophyllin sodium 0.001% by mass to 0.5% by mass, and (B) water 10% by mass to 90% by mass, 1 or 2 or more types of polyvalent metals or salts thereof whose pH at 25 ° C. is more than 7 and 12 or less, and selected from copper, iron, calcium, magnesium, aluminum, zinc, and tin other than component (A) Relates to a composition for oral cavity having a metal atom equivalent of 0.02% by mass or less.
The present invention also includes the following components (A) and (B):
(A) One or more chlorophyll compounds selected from copper chlorophyllin sodium and iron chlorophyllin sodium 0.001% by mass to 0.5% by mass, and (B) water 10% by mass to 90% by mass I),
The content of one or more polyvalent metals selected from copper, iron, calcium, magnesium, aluminum, zinc, and tin other than the component (A) or a salt thereof is 0.02% by mass in terms of metal atoms. Step (II) for adjusting to be as follows, and Step (III) for adjusting pH at 25 ° C. to greater than 7 and 12 or less
It is related with the manufacturing method of the composition for oral cavity provided with.
本発明によれば、銅クロロフィリンナトリウムや鉄クロロフィリンナトリウムの安定性を効果的に保持し、さらには銅クロロフィリンナトリウムによる変色をも抑制し、歯肉炎予防効果や口臭予防効果を充分に発揮させることが可能である。 According to the present invention, it is possible to effectively maintain the stability of copper chlorophyllin sodium and iron chlorophyllin sodium, further suppress discoloration due to copper chlorophyllin sodium, and sufficiently exhibit gingivitis prevention effects and bad breath prevention effects. Is possible.
以下、本発明について詳細に説明する。
本発明の口腔用組成物は、成分（Ａ）として、銅クロロフィリンナトリウム、及び鉄クロロフィリンナトリウムから選ばれる１種以上のクロロフィル化合物を０．００１質量％以上０．５質量％以下含有する。本発明の口腔用組成物においては、クロロフィル化合物が有する嵩高い骨格内に銅や鉄を安定して存在させることができ、かかる化合物から銅イオンや鉄イオンが放出されて不要な反応が生じるのを効果的に抑制し、その余の不純物又は沈殿物の生成をも回避して、組成物の美観を良好に保持することができる。
Hereinafter, the present invention will be described in detail.
The composition for oral cavity of this invention contains 0.001 mass% or more and 0.5 mass% or less of 1 or more types of chlorophyll compounds chosen from copper chlorophyllin sodium and iron chlorophyllin sodium as a component (A). In the composition for oral cavity of the present invention, copper and iron can be stably present in the bulky skeleton of the chlorophyll compound, and copper ions and iron ions are released from such compounds, causing unnecessary reactions. Can be effectively suppressed, the formation of other impurities or precipitates can be avoided, and the aesthetic appearance of the composition can be maintained well.
成分（Ａ）の含有量は、成分（Ａ）による歯肉炎予防効果や口臭予防効果を充分に発揮させる観点から、本発明の口腔用組成物中に、０．００１質量％以上であって、好ましくは０．００４質量％以上であり、より好ましくは０．００７質量％以上である。また、成分（Ａ）の含有量は、成分（Ａ）の安定性を確保しつつ、不要な反応を効果的に抑制する観点から、本発明の口腔用組成物中に、０．５質量％以下であって、好ましくは０．３質量％以下であり、より好ましくは０．１質量％以下であり、さらに好ましくは０．０５質量％以下である。そして、成分（Ａ）の含有量は、本発明の口腔用組成物中に、０．００１質量％以上０．５質量％以下であって、好ましくは０．００４〜０．３質量％であり、より好ましくは０．００７〜０．０５質量％である。 The content of the component (A) is 0.001% by mass or more in the oral composition of the present invention from the viewpoint of sufficiently exerting the gingivitis preventing effect and the bad breath preventing effect by the component (A), Preferably it is 0.004 mass% or more, More preferably, it is 0.007 mass% or more. Moreover, content of a component (A) is 0.5 mass% in the composition for oral cavity of this invention from a viewpoint which suppresses an unnecessary reaction effectively, ensuring the stability of a component (A). It is below, Preferably it is 0.3 mass% or less, More preferably, it is 0.1 mass% or less, More preferably, it is 0.05 mass% or less. And content of a component (A) is 0.001 to 0.5 mass% in the composition for oral cavity of this invention, Preferably it is 0.004 to 0.3 mass%. More preferably, it is 0.007-0.05 mass%.
本発明の口腔用組成物は、成分（Ｂ）として、水を１０質量％以上９０質量％以下含有する。これにより、上記成分（Ａ）及び後述する成分（Ｃ）フッ素イオン供給化合物等の各成分を溶解又は分散させて、口腔内で良好に拡散させ、成分（Ａ）及び成分（Ｃ）によりもたらされる効果を充分に発揮させることができる。 The composition for oral cavity of this invention contains 10 mass% or more and 90 mass% or less of water as a component (B). Thereby, each component such as the component (A) and the component (C) fluorine ion supply compound described later is dissolved or dispersed and diffused well in the oral cavity, resulting in the component (A) and the component (C). The effect can be exhibited sufficiently.
例えば、本発明の口腔用組成物が、練歯磨剤や粉歯磨剤等の歯磨組成物である場合、かかる成分（Ｂ）の含有量は、本発明の口腔用組成物中に、１０質量％以上であって、好ましくは１２質量％以上であり、より好ましくは１５質量％以上であり、さらに好ましくは２０質量％以上であり、好ましくは６０質量％以下であり、より好ましくは５０質量％以下であり、さらに好ましくは４５質量％以下である。さらに、本発明の口腔用組成物が歯磨組成物である場合、成分（Ｂ）の含有量と成分（Ａ）の含有量との質量比（（Ｂ）／（Ａ））は、組成物中において成分（Ａ）を良好に溶解又は分散させて、成分（Ａ）による所望の効果を充分に発揮させる観点から、好ましくは５００以上であり、より好ましくは１０００以上であり、さらに好ましくは３０００以上である。また、本発明の口腔用組成物が歯磨組成物である場合、成分（Ｂ）の含有量と成分（Ａ）の含有量との質量比（（Ｂ）／（Ａ））は、成分（Ａ）の安定性を良好に保持し、変色抑制効果を充分に発揮させる観点から、好ましくは６５００以下であり、より好ましくは６０００以下であり、さらに好ましくは５５００以下であり、よりさらに好ましくは５０００以下である。そして、本発明の口腔用組成物が歯磨組成物である場合、成分（Ｂ）の含有量と成分（Ａ）の含有量との質量比（（Ｂ）／（Ａ））は、好ましくは５００〜６５００であり、より好ましくは１０００〜６０００であり、さらに好ましくは３０００〜５５００であり、よりさらに好ましくは３０００〜５０００以下である。 For example, when the oral composition of the present invention is a dentifrice composition such as a toothpaste or a powder dentifrice, the content of the component (B) is 10% by mass in the oral composition of the present invention. It is above, Preferably it is 12 mass% or more, More preferably, it is 15 mass% or more, More preferably, it is 20 mass% or more, Preferably it is 60 mass% or less, More preferably, it is 50 mass% or less More preferably, it is 45 mass% or less. Furthermore, when the composition for oral cavity of this invention is a dentifrice composition, mass ratio ((B) / (A)) of content of a component (B) and content of a component (A) is in composition. In view of sufficiently dissolving or dispersing the component (A) in order to sufficiently exhibit the desired effect of the component (A), it is preferably 500 or more, more preferably 1000 or more, and still more preferably 3000 or more. It is. Moreover, when the composition for oral cavity of this invention is a dentifrice composition, mass ratio ((B) / (A)) of content of a component (B) and content of a component (A) is component (A). ) Is maintained at a satisfactory level and the effect of suppressing discoloration is sufficiently exerted, it is preferably 6500 or less, more preferably 6000 or less, further preferably 5500 or less, and even more preferably 5000 or less. It is. And when the composition for oral cavity of this invention is a dentifrice composition, mass ratio ((B) / (A)) of content of a component (B) and content of a component (A) becomes like this. Preferably it is 500. It is -6500, More preferably, it is 1000-6000, More preferably, it is 3000-5500, More preferably, it is 3000-5000 or less.
また、成分（Ｂ）の含有量は、本発明の口腔用組成物が、洗口剤や液状歯磨剤等の液体口腔用組成物である場合、本発明の口腔用組成物中に、９０質量％以下であって、好ましくは８８質量％以下であり、好ましくは６０質量％以上であり、より好ましくは７０質量％以上である。さらに、本発明の口腔用組成物が液体口腔用組成物である場合、成分（Ｂ）の含有量と成分（Ａ）の含有量との質量比（（Ｂ）／（Ａ））は、組成物中において成分（Ａ）を良好に溶解又は分散させて、成分（Ａ）による所望の効果を充分に発揮させる観点から、好ましくは６５００以上であり、より好ましくは７０００以上であり、さらに好ましくは７５００以上である。また、本発明の口腔用組成物が液体口腔用組成物である場合、成分（Ｂ）の含有量と成分（Ａ）の含有量との質量比（（Ｂ）／（Ａ））は、成分（Ａ）の安定性を良好に保持し、変色抑制効果を充分に発揮させる観点から、好ましくは９０００以下であり、より好ましくは８８００以下であり、さらに好ましくは８６００以下である。そして、本発明の口腔用組成物が液体口腔用組成物である場合、成分（Ｂ）の含有量と成分（Ａ）の含有量との質量比（（Ｂ）／（Ａ））は、好ましくは６５００〜９０００であり、より好ましくは７０００〜８８００であり、さらに好ましくは７５００〜８６００である。 Moreover, content of a component (B) is 90 masses in the oral cavity composition of this invention, when the oral cavity composition of this invention is liquid oral cavity compositions, such as a mouthwash and a liquid dentifrice. % Or less, preferably 88% by mass or less, preferably 60% by mass or more, and more preferably 70% by mass or more. Further, when the oral composition of the present invention is a liquid oral composition, the mass ratio ((B) / (A)) of the content of the component (B) and the content of the component (A) is the composition. From the viewpoint of satisfactorily dissolving or dispersing the component (A) in the product and fully exhibiting the desired effect of the component (A), it is preferably 6500 or more, more preferably 7000 or more, and still more preferably 7500 or more. Moreover, when the composition for oral cavity of this invention is a composition for liquid oral cavity, mass ratio ((B) / (A)) of content of a component (B) and content of a component (A) is a component. From the viewpoint of satisfactorily maintaining the stability of (A) and sufficiently exhibiting the discoloration suppressing effect, it is preferably 9000 or less, more preferably 8800 or less, and even more preferably 8600 or less. When the oral composition of the present invention is a liquid oral composition, the mass ratio ((B) / (A)) between the content of the component (B) and the content of the component (A) is preferably Is 6500-9000, More preferably, it is 7000-8800, More preferably, it is 7500-8600.
本発明の口腔用組成物が歯磨組成物である場合、その水分量は、配合した水分量及び配合した成分中の水分量から計算によって算出することもできるが、例えばカールフィッシャー水分計で測定することができる。カールフィッシャー水分計としては、例えば、微量水分測定装置（平沼産業（株））を用いることができる。この装置では、歯磨組成物を５ｇとり、無水メタノール２５ｇに懸濁させ、この懸濁液０．０２ｇを分取して水分量を測定することができる。 When the oral composition of the present invention is a dentifrice composition, its water content can be calculated from the blended moisture content and the moisture content in the blended component, but is measured, for example, with a Karl Fischer moisture meter. be able to. As the Karl Fischer moisture meter, for example, a trace moisture measuring device (Hiranuma Sangyo Co., Ltd.) can be used. In this apparatus, 5 g of the dentifrice composition can be taken and suspended in 25 g of anhydrous methanol, and 0.02 g of this suspension can be collected to measure the amount of water.
本発明の口腔用組成物は、さらにフッ素イオン供給化合物（Ｃ）をフッ素原子換算量で９５ｐｐｍ以上５０００ｐｐｍ以下含有することができる。成分（Ａ）の安定性が確保される本発明の口腔用組成物においては、かかるフッ素イオン供給化合物から放出されるフッ素イオンとの不要な反応が生じるのをも効果的に抑制して、不要な沈殿物を生成することなく、フッ素イオンを安定して口腔内にて供給することができ、歯のエナメル質におけるフッ素イオンの取り込み量を有効に増大させて再石灰化促進効果を充分に発揮させることが可能となる。 The composition for oral cavity of this invention can contain 95 ppm or more and 5000 ppm or less of fluorine ion supply compounds (C) in fluorine atom conversion amount further. In the composition for oral cavity of the present invention in which the stability of the component (A) is ensured, unnecessary reaction with fluorine ions released from the fluorine ion supply compound is also effectively suppressed, and is unnecessary. Fluoride ions can be stably supplied in the oral cavity without generating a significant precipitate, and the amount of fluoride ions taken up in the tooth enamel can be effectively increased to fully promote remineralization. It becomes possible to make it.
成分（Ｃ）としては、フッ化ナトリウム、フッ化カリウム、フッ化アンモニウム、フッ化水素酸ヘキシルアミン、フッ化水素酸デカノールアミン、及びフッ化水素酸オクタデセニルアミンから選ばれる１種又は２種以上のフッ化物が挙げられる。なかでも、効率的にフッ化カルシウムを形成し、歯へのフッ素イオンの取り込み量を有効に増大させる観点から、成分（Ｃ）としてフッ化ナトリウムを含むのが好ましい。 As the component (C), one or two selected from sodium fluoride, potassium fluoride, ammonium fluoride, hexylamine hydrofluoride, decanolamine hydrofluoride, and octadecenylamine hydrofluoride Species or fluorides may be mentioned. Especially, it is preferable to contain sodium fluoride as a component (C) from a viewpoint of forming calcium fluoride efficiently and effectively increasing the uptake | capture amount of the fluorine ion to a tooth | gear.
成分（Ｃ）の含有量は、フッ素イオンを安定して供給し、再石灰化促進効果を充分に発揮させる観点から、本発明の口腔用組成物中に、フッ素原子換算量で好ましくは９５ｐｐｍ以上であり、より好ましくは４５０ｐｐｍ以上であり、さらに好ましくは７００ｐｐｍ以上であり、よりさらに好ましくは９００ｐｐｍ以上である。また、成分（Ｃ）の含有量は、成分（Ｃ）のみならず成分（Ａ）をも起因とし得る不要な沈殿物の生成を抑制し、組成物の安定性を図る観点から、本発明の口腔用組成物中に、フッ素原子換算量で好ましくは５０００ｐｐｍ以下であり、より好ましくは４０００ｐｐｍ以下であり、さらに好ましくは３０００ｐｐｍ以下であり、よりさらに好ましくは２５００ｐｐｍ以下である。そして、成分（Ｃ）の含有量は、本発明の口腔用組成物中に、フッ素原子換算量で好ましくは９５ｐｐｍ以上５０００ｐｐｍ以下であり、より好ましくは４５０〜４０００ｐｐｍであり、さらに好ましくは７００〜３０００ｐｐｍであり、よりさらに好ましくは９００〜２５００ｐｐｍである。 The content of the component (C) is preferably 95 ppm or more in terms of fluorine atom in the oral composition of the present invention, from the viewpoint of stably supplying fluorine ions and sufficiently exhibiting the effect of promoting remineralization. More preferably, it is 450 ppm or more, More preferably, it is 700 ppm or more, More preferably, it is 900 ppm or more. In addition, the content of the component (C) suppresses the generation of unnecessary precipitates that can be attributed not only to the component (C) but also the component (A), from the viewpoint of improving the stability of the composition. In the composition for oral cavity, it is preferably 5000 ppm or less, more preferably 4000 ppm or less, still more preferably 3000 ppm or less, and still more preferably 2500 ppm or less in terms of fluorine atom. The content of the component (C) is preferably 95 ppm or more and 5000 ppm or less, more preferably 450 to 4000 ppm, further preferably 700 to 3000 ppm in terms of fluorine atom in the composition for oral cavity of the present invention. More preferably, it is 900-2500 ppm.
成分（Ｃ）の含有量は、フッ素イオンを安定して供給し、再石灰化促進効果を充分に発揮させる観点から、本発明の口腔用組成物中に、フッ素原子換算量で好ましくは０．００９５質量％以上であって、好ましくは０．０４５質量％以上であり、より好ましくは０．０７質量％以上であり、さらに好ましくは０．０９質量％以上である。また、成分（Ｃ）の含有量は、成分（Ｃ）のみならず成分（Ａ）をも起因とし得る不要な沈殿物の生成を抑制し、組成物の安定性を図る観点から、本発明の口腔用組成物中に、フッ素原子換算量で０．５質量％以下であって、好ましくは０．４質量％以下であり、より好ましくは０．３質量％以下であり、さらに好ましくは０．２５質量％である。そして、成分（Ｃ）の含有量は、本発明の口腔用組成物中に、フッ素原子換算量で好ましくは０．００９５質量％以上０．５質量％以下であり、より好ましくは０．０４５〜０．４質量％であり、さらに好ましくは０．０７〜０．３質量％であり、よりさらに好ましくは０．０９〜０．２５質量％である。 The content of the component (C) is preferably 0.1 in terms of fluorine atom in the oral composition of the present invention, from the viewpoint of stably supplying fluorine ions and sufficiently exhibiting the effect of promoting remineralization. It is 0095% by mass or more, preferably 0.045% by mass or more, more preferably 0.07% by mass or more, and further preferably 0.09% by mass or more. In addition, the content of the component (C) suppresses the generation of unnecessary precipitates that can be attributed not only to the component (C) but also the component (A), from the viewpoint of improving the stability of the composition. In the composition for oral cavity, the amount in terms of fluorine atom is 0.5% by mass or less, preferably 0.4% by mass or less, more preferably 0.3% by mass or less, and still more preferably 0.00%. 25% by mass. The content of the component (C) is preferably 0.0095% by mass or more and 0.5% by mass or less, more preferably 0.045% by mass or less in terms of fluorine atom in the oral composition of the present invention. It is 0.4 mass%, More preferably, it is 0.07-0.3 mass%, More preferably, it is 0.09-0.25 mass%.
なお、成分（Ｃ）としてフッ化ナトリウムを含む場合、かかるフッ化ナトリウムの含有量は、本発明の口腔用組成物中に、好ましくは０．０２〜１質量％であり、より好ましくは０．０６〜０．７質量％であり、さらに好ましくは０．１〜０．４質量％である。 In addition, when sodium fluoride is included as a component (C), content of this sodium fluoride is preferably 0.02-1 mass% in the composition for oral cavity of this invention, More preferably, it is 0.00. It is 06-0.7 mass%, More preferably, it is 0.1-0.4 mass%.
本発明の練歯磨組成物は、成分（Ｃ）のフッ素イオン供給化合物以外のフッ化物として、モノフルオロリン酸等の含フッ素化合物を含有することができる。かかる含フッ素化合物を含有することにより、フッ素イオンの取り込み量の増大をさらに補強することが可能となる。含フッ素化合物の含有量は、本発明の練歯磨組成物中に、好ましくは０．２〜３質量％であり、より好ましくは０．６〜２質量％である。 The toothpaste composition of the present invention can contain a fluorine-containing compound such as monofluorophosphoric acid as a fluoride other than the component (C) fluorine ion supply compound. By containing such a fluorine-containing compound, it is possible to further reinforce the increase in the amount of fluorine ions taken up. The content of the fluorine-containing compound is preferably 0.2 to 3% by mass, more preferably 0.6 to 2% by mass in the toothpaste composition of the present invention.
成分（Ａ）の含有量と成分（Ｃ）のフッ素原子換算量との質量比（（Ａ）／（Ｃ））は、成分（Ａ）の安定性と成分（Ｃ）のフッ素イオン供給の安定性とを有効に両立させる観点から、好ましくは０．０１以上であり、より好ましくは０．０３以上であり、さらに好ましくは０．０５以上である。また、成分（Ａ）の含有量と成分（Ｃ）のフッ素原子換算量との質量比（（Ａ）／（Ｃ））は、組成物の変色抑制効果を高めつつ高いフッ素イオンの取り込み量を確保する観点から、好ましくは１以下であり、より好ましくは０．７以下であり、さらに好ましくは０．４以下であり、よりさらに好ましくは０．２以下である。そして、成分（Ａ）の含有量と成分（Ｃ）のフッ素原子換算量との質量比（（Ａ）／（Ｃ））は、好ましくは０．０１〜１であり、より好ましくは０．０３〜０．７であり、さらに好ましくは０．０５〜０．４であり、よりさらに好ましくは０．０５〜０．２である。 The mass ratio ((A) / (C)) between the content of component (A) and the amount of fluorine atom equivalent of component (C) is the stability of component (A) and the stability of fluorine ion supply of component (C). From the viewpoint of effectively balancing the properties, it is preferably 0.01 or more, more preferably 0.03 or more, and still more preferably 0.05 or more. Further, the mass ratio ((A) / (C)) of the content of component (A) and the amount of component (C) converted to fluorine atoms ((A) / (C)) increases the uptake of fluorine ions while enhancing the effect of suppressing discoloration of the composition. From the viewpoint of ensuring, it is preferably 1 or less, more preferably 0.7 or less, further preferably 0.4 or less, and still more preferably 0.2 or less. And mass ratio ((A) / (C)) of content of a component (A) and a fluorine atom conversion amount of a component (C) becomes like this. Preferably it is 0.01-1, More preferably, it is 0.03. It is -0.7, More preferably, it is 0.05-0.4, More preferably, it is 0.05-0.2.
なお、成分（Ｃ）としてフッ化ナトリウムを含む場合、成分（Ａ）の含有量とかかるフッ化ナトリウムの含有量との質量比（（Ａ）／フッ化ナトリウム）は、成分（Ａ）の安定性と成分（Ｃ）のフッ素イオン供給の安定性とを有効に両立させる観点から、好ましくは０．０１〜０．５であり、より好ましくは０．０２〜０．２であり、さらに好ましくは０．０３〜０．１である。 In addition, when sodium fluoride is included as component (C), the mass ratio ((A) / sodium fluoride) of the content of component (A) and the content of sodium fluoride is the stability of component (A). From the viewpoint of effectively balancing the stability of the fluorine ion supply of component (C), it is preferably 0.01 to 0.5, more preferably 0.02 to 0.2, still more preferably 0.03 to 0.1.
本発明の口腔用組成物が歯磨組成物である場合は、さらに粘結剤を含有することが好ましい。粘結剤としては、アルギン酸ナトリウム、カルボキシメチルセルロースナトリウム、カラギーナン、キサンタンガム、ポリアクリル酸ナトリウム、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、ペクチン、トラガントガム、アラビアガム、グアーガム、カラヤガム、ローカストビーンガム、ジェランガム、タマリンドガム、サイリウムシードガム、ポリビニルアルコール、コンドロイチン硫酸ナトリウム及びメトキシエチレン無水マレイン酸共重合体等からなる群より選ばれる１種又は２種以上を用いることができる。なかでも、粘結剤は、エーテル化度が０．７〜２．０のカルボキシメチルセルロースナトリウム、カラギーナン、キサンタンガムから選ばれる１種又は２種以上が好ましく、２種以上がより好ましい。粘結剤の含有量は、本発明の口腔用組成物中に、好ましくは０．３質量％以上であり、より好ましくは０．４質量％以上であり、好ましくは２質量％以下であり、より好ましくは１．５質量％以下である。また、本発明の口腔用組成物が歯磨組成物である場合は、粘結剤とともに、増粘性シリカ（ＪＩＳ Ｋ５１０１-１３-２に準ずる方法により測定される吸油量が、２００〜４００ｍＬ／１００ｇ）を１質量％以上１２質量％以下含有することが好ましい。 When the oral composition of the present invention is a dentifrice composition, it is preferable to further contain a binder. Binders include sodium alginate, sodium carboxymethylcellulose, carrageenan, xanthan gum, sodium polyacrylate, hydroxyethylcellulose, hydroxypropylcellulose, pectin, tragacanth gum, gum arabic, guar gum, caraya gum, locust bean gum, gellan gum, tamarind gum, psyllium One or more selected from the group consisting of seed gum, polyvinyl alcohol, sodium chondroitin sulfate, methoxyethylene maleic anhydride copolymer, and the like can be used. Among these, the binder is preferably one or more selected from sodium carboxymethyl cellulose having a degree of etherification of 0.7 to 2.0, carrageenan, and xanthan gum, and more preferably two or more. The content of the binder is preferably 0.3% by mass or more, more preferably 0.4% by mass or more, and preferably 2% by mass or less in the oral composition of the present invention. More preferably, it is 1.5 mass% or less. Moreover, when the composition for oral cavity of this invention is a dentifrice composition, it is a thickening silica (the oil absorption amount measured by the method according to JISK5101-13-1 is 200-400 mL / 100g) with a binder. It is preferable to contain 1 mass% or more and 12 mass% or less.
本発明の口腔用組成物が歯磨組成物である場合は、本発明の効果を阻害しない範囲でさらに研磨剤を含有することができる。研磨剤としては、例えばリン酸カルシウム、リン酸水素カルシウム、炭酸カルシウム、水酸化アルミニウム、ケイ酸アルミニウム、ケイ酸ジルコニウム、研磨性シリカ（ＪＩＳ Ｋ５１０１−１３−２に準ずる方法により測定される吸油量が、５０〜１５０ｍＬ／１００ｇ）等が挙げられる。研磨剤は、ＲＤＡ値（Radioactive Dentine Abrasion values、ＩＳＯ１１６０９研磨性の試験方法 付随書Ａにより測定される値）が２０〜２５０のものが一般に用いられる。本発明の口腔用組成物は、高いタンパク質汚れの除去効果と付着抑制効果に加え、優れた清掃実効感をもたらすことから、研磨剤の含有量を低減しても優れた効果を発揮することができる。研磨剤の含有量は、本発明の口腔用組成物中に、好ましくは１質量％以上であり、好ましくは２０質量％以下であり、より好ましくは１０質量％以下である。 When the composition for oral cavity of the present invention is a dentifrice composition, an abrasive can be further contained as long as the effects of the present invention are not impaired. As the abrasive, for example, calcium phosphate, calcium hydrogen phosphate, calcium carbonate, aluminum hydroxide, aluminum silicate, zirconium silicate, abrasive silica (oil absorption measured by a method according to JIS K5101-13-3 is 50 -150mL / 100g) etc. are mentioned. As the abrasive, one having an RDA value (Radioactive Dentine Abrasion values, a value measured by ISO 11609 abrasive test method appendix A) of 20 to 250 is generally used. The composition for oral cavity of the present invention brings about excellent cleaning effectiveness in addition to the high protein soil removal effect and adhesion suppression effect, and therefore can exhibit excellent effects even if the content of the abrasive is reduced. it can. The content of the abrasive is preferably 1% by mass or more, preferably 20% by mass or less, and more preferably 10% by mass or less in the composition for oral cavity of the present invention.
本発明の口腔用組成物において、成分（Ａ）以外の銅、鉄、カルシウム、マグネシウム、アルミニウム、亜鉛、及び錫から選ばれる１種又は２種以上の多価金属又はその塩の含有量は、金属原子換算量で０．０２質量％以下である。かかる成分（Ａ）以外の銅、鉄、カルシウム、マグネシウム、アルミニウム、亜鉛、及び錫から選ばれる１種又は２種以上の多価金属又はその塩が存在すると、多価金属イオンが放出され、成分（Ａ）に存在する銅や鉄も不安定となってイオン化し、これと置き換わるおそれがあるだけでなく、成分（Ｃ）を含有する場合には、かかる成分により供給されるフッ素イオンとともにフッ化金属塩を形成し、成分（Ｃ）によるフッ素イオン供給が阻害するおそれもあることから、金属原子換算量を基準にその含有を制限するものである。 In the oral composition of the present invention, the content of one or more polyvalent metals selected from copper, iron, calcium, magnesium, aluminum, zinc, and tin other than the component (A) or a salt thereof is It is 0.02% by mass or less in terms of metal atom. In the presence of one or more polyvalent metals or salts thereof selected from copper, iron, calcium, magnesium, aluminum, zinc, and tin other than component (A), polyvalent metal ions are released, and the component The copper and iron present in (A) may also become unstable and ionize, which may replace them, and if it contains component (C), it may be fluorided together with the fluorine ions supplied by such component. Since the metal salt is formed and there is a possibility that the supply of fluorine ions by the component (C) may be hindered, its content is limited based on the metal atom equivalent amount.
かかる成分（Ａ）以外の銅、鉄、カルシウム、マグネシウム、アルミニウム、亜鉛、及び錫から選ばれる１種又は２種以上の多価金属又はその塩の含有量は、本発明の口腔用組成物中に、金属原子換算量で０．０２質量％以下であって、好ましくは０．０１質量％以下であり、より好ましくは０．００２質量％以下であり、或いは本発明の口腔用組成物は、これらカルシウム、マグネシウム、アルミニウム、亜鉛、及び錫から選ばれる１種又は２種以上の多価金属又はその塩を含有しないのが好ましい。
また、上記多価金属又はその塩の金属原子換算量を成分（Ａ）の銅原子換算量及び鉄原子換算量の合計量で除した値（上記多価金属又はその塩の金属原子換算量／成分（Ａ）の銅原子換算量及び鉄原子換算量の合計量）は、成分（Ａ）を組成物中に安定に含有させる観点から、８０以下であり、好ましくは４０以下であり、より好ましくは１以下である。
なお、上記多価金属又はその塩の含有量は、ＩＣＰ発光分析法（ＩＣＰ発光分析装置：Ｐｅｒｋｉｎ Ｅｌｍｅｒ社 Ｏｐｔｉｍａ ５３００ＤＶ）で測定し、金属原子量に換算することにより求めることができる。
The content of one or more polyvalent metals selected from copper, iron, calcium, magnesium, aluminum, zinc, and tin other than the component (A) or a salt thereof is in the oral composition of the present invention. In addition, it is 0.02% by mass or less in terms of metal atom, preferably 0.01% by mass or less, more preferably 0.002% by mass or less, or the oral composition of the present invention comprises: It is preferable not to contain one or more polyvalent metals or salts thereof selected from these calcium, magnesium, aluminum, zinc, and tin.
Further, a value obtained by dividing the equivalent amount of metal of the polyvalent metal or salt thereof by the total amount of equivalent amount of copper atom and equivalent of iron atom of component (A) (the equivalent amount of metal atom of the polyvalent metal or salt thereof / The total amount of component (A) in terms of copper atom and iron atom) is 80 or less, preferably 40 or less, more preferably from the viewpoint of stably containing component (A) in the composition. Is 1 or less.
In addition, content of the said polyvalent metal or its salt can be calculated | required by measuring by ICP emission spectrometry (ICP emission analysis apparatus: Optima 5300DV of Perkin Elmer), and converting into metal atomic weight.
かかる成分（Ａ）以外の銅、鉄、カルシウム、マグネシウム、アルミニウム、亜鉛、及び錫から選ばれる１種又は２種以上の多価金属又はその塩の含有量は、本発明の口腔用組成物中に、金属原子モル換算量で０．００１８モル％以下であって、好ましくは０．００１５モル％以下であり、より好ましくは０．０００２モル％以下であり、或いは本発明の口腔用組成物は、カルシウム、マグネシウム、アルミニウム、亜鉛、及び錫から選ばれる１種又は２種以上の多価金属又はその塩を含有しないのが好ましい。
そして、上記多価金属又はその塩の金属原子モル換算量を成分（Ａ）の銅原子モル換算量及び鉄原子モル換算量の合計量で割ったモル比（上記多価金属又はその塩の金属原子モル換算量／成分（Ａ）の銅原子モル換算量及び鉄原子モル換算量の合計量）は、成分（Ａ）を組成物中に安定に含有させる観点から、１２０以下であり、好ましくは６０以下であり、より好ましくは１．５以下である。
なお、上記多価金属又はその塩の金属原子モル換算量は、ＩＣＰ発光分析法（ＩＣＰ発光分析装置：Ｐｅｒｋｉｎ Ｅｌｍｅｒ社 Ｏｐｔｉｍａ ５３００ＤＶ）で測定し、金属原子量をさらにモル量に換算することにより求めることができる。
The content of one or more polyvalent metals selected from copper, iron, calcium, magnesium, aluminum, zinc, and tin other than the component (A) or a salt thereof is in the oral composition of the present invention. In addition, it is 0.0018 mol% or less, preferably 0.0015 mol% or less, more preferably 0.0002 mol% or less in terms of metal atom mol, or the oral composition of the present invention is It is preferable not to contain one or more polyvalent metals selected from calcium, magnesium, aluminum, zinc, and tin, or a salt thereof.
And the molar ratio (the metal of the said polyvalent metal or its salt) which divided the metal atom molar equivalent of the said polyvalent metal or its salt by the total amount of the copper atom molar equivalent of the component (A) and the iron atom molar equivalent. From the viewpoint of stably containing the component (A) in the composition, the atomic molar equivalent / the total amount of the copper atomic molar equivalent and the iron atomic molar equivalent of the component (A) is preferably 120 or less, preferably 60 or less, more preferably 1.5 or less.
In addition, the metal atom molar conversion amount of the said polyvalent metal or its salt is calculated | required by measuring by ICP emission spectrometry (ICP emission analysis apparatus: Perkin Elmer Optima 5300DV), and converting metal atom amount into a molar amount further. Can do.
なお、成分（Ａ）を組成物中により安定に含有させる観点から、成分（Ａ）以外の銅、鉄、カルシウム、マグネシウム、アルミニウム、亜鉛、及び錫から選ばれる１種又は２種
以上の多価金属を含有しないのが好ましい。
In addition, from the viewpoint of more stably containing the component (A) in the composition, one or more polyvalents selected from copper, iron, calcium, magnesium, aluminum, zinc, and tin other than the component (A) are used. It is preferable not to contain a metal.
本発明の口腔用組成物は、成分（Ａ）による歯肉炎予防効果や口臭予防効果を充分に発揮させる観点、及び成分（Ｃ）により放出されるフッ素イオンとの間でフッ化金属塩が形成されるのを有効に防止する観点から、成分（Ａ）以外の銅化合物及び鉄化合物の含有を制限するのが好ましい。かかる成分（Ａ）以外の銅化合物としては、例えば、硫酸銅；塩化銅や臭化銅等のハロゲン化銅；硝酸銅；ギ酸又はカルボン酸等の銅塩；シュウ酸やスべリン酸等の銅塩；グリコール酸、乳酸、酒石酸、リンゴ酸又はクエン酸等のヒドロキシカルボン酸の銅塩のほか、安息香酸銅、グルコン酸銅、フィチン酸銅、グリセロリン酸銅、プロピオン酸銅、サリチル酸銅が挙げられる。かかる成分（Ａ）以外の鉄化合物としては、例えば、酸化鉄、塩化鉄、酢酸鉄、硝酸鉄、臭化鉄、四ホウ化鉄、水酸化鉄、乳酸鉄、ヨウ化鉄、硫化鉄、硫酸アンモニウム鉄、リン酸鉄、クエン酸鉄、フェロシアン化第二鉄が挙げられる。 In the composition for oral cavity of the present invention, a metal fluoride salt is formed between the viewpoint of sufficiently exerting the gingivitis prevention effect and bad breath prevention effect by the component (A) and the fluorine ion released by the component (C). From the viewpoint of effectively preventing this, it is preferable to limit the content of copper compounds and iron compounds other than the component (A). Examples of the copper compound other than the component (A) include copper sulfate; copper halides such as copper chloride and copper bromide; copper nitrate; copper salts such as formic acid and carboxylic acid; oxalic acid and suberic acid. Copper salt: In addition to copper salt of hydroxycarboxylic acid such as glycolic acid, lactic acid, tartaric acid, malic acid or citric acid, copper benzoate, copper gluconate, copper phytate, copper glycerophosphate, copper propionate, copper salicylate It is done. Examples of iron compounds other than the component (A) include iron oxide, iron chloride, iron acetate, iron nitrate, iron bromide, iron tetraboride, iron hydroxide, iron lactate, iron iodide, iron sulfide, and ammonium sulfate. Examples include iron, iron phosphate, iron citrate, and ferric ferrocyanide.
成分（Ａ）以外の銅化合物及び鉄化合物の合計含有量は、本発明の口腔用組成物中に、好ましくは０．１質量％以下であり、より好ましくは０．０１質量％以下であり、さらに好ましくは０．００５質量％以下であり、或いは不可避的に混入する場合を除き、成分（Ａ）以外の銅化合物及び鉄化合物を含有しないのが好ましい。 The total content of the copper compound and the iron compound other than the component (A) is preferably 0.1% by mass or less, more preferably 0.01% by mass or less, in the composition for oral cavity of the present invention, More preferably, it is 0.005 mass% or less, or it is preferable not to contain copper compounds and iron compounds other than a component (A) except the case where it inevitably mixes.
本発明の口腔用組成物は、成分（Ａ）の安定性を高め、組成物の変色抑制効果の向上を図る観点から、グリセリンを含有するのが好ましい。かかるグリセリンの含有量は、本発明の口腔用組成物中に、好ましくは５質量％以上であり、より好ましくは１０質量％以上であり、好ましくは３０質量％以下であり、より好ましくは２５質量％以下である。 The oral composition of the present invention preferably contains glycerin from the viewpoint of enhancing the stability of the component (A) and improving the discoloration suppressing effect of the composition. The glycerin content in the oral composition of the present invention is preferably 5% by mass or more, more preferably 10% by mass or more, preferably 30% by mass or less, more preferably 25% by mass. % Or less.
本発明の口腔用組成物は、必要に応じてソルビトールを含有することができるが、成分（Ａ）の安定性をより高め、組成物の変色抑制効果を充分に発揮させる観点から、ソルビトールの含有を制限するのが望ましい。かかるソルビトールの含有量は、本発明の口腔用組成物中に、好ましくは５０質量％以下であり、より好ましくは４０質量％以下であり、さらに好ましくは３０質量％以下であり、またさらに好ましくは２５質量％以下であり、ソルビトールを５質量％以上含有させることもできる。 The oral composition of the present invention can contain sorbitol as necessary, but from the viewpoint of further enhancing the stability of the component (A) and sufficiently exhibiting the effect of suppressing discoloration of the composition. It is desirable to limit The sorbitol content in the oral composition of the present invention is preferably 50% by mass or less, more preferably 40% by mass or less, still more preferably 30% by mass or less, and still more preferably. It is 25 mass% or less, and 5 mass% or more of sorbitol can also be contained.
本発明の口腔用組成物は、さらに、本発明の効果を阻害しない範囲で、キシリトール、エリスリトール、還元パラチノース、マンニトール等のソルビトール以外の糖アルコール；ヒドロキシアパタイト等の象牙質知覚過敏用成分；グリセリン、ポリエチレングリコール、プロピレングリコール等の湿潤剤；香料；成分（Ａ）以外の殺菌剤や抗炎症剤等の薬効成分；防腐剤；植物抽出物；その他有効成分等を含有することができる。 The composition for oral cavity of the present invention is a sugar alcohol other than sorbitol such as xylitol, erythritol, reduced palatinose, mannitol, and the like; Wetting agents such as polyethylene glycol and propylene glycol; fragrances; medicinal components such as bactericides and anti-inflammatory agents other than component (A); antiseptics; plant extracts; and other active ingredients.
本発明の口腔用組成物の２５℃におけるｐＨは、成分（Ａ）の安定性を確保して、組成物の変色を有効に抑制しつつ、成分（Ｂ）によるフッ素イオン供給効果との両立を図る観点から、７を超え、好ましくは８以上であり、より好ましくは８．６以上である。また、本発明の口腔用組成物の２５℃におけるｐＨは、成分（Ｂ）によるフッ素イオン供給効果の低下を抑制する観点、及び為害性等の発現を防止する観点から、１２以下であって、好ましくは１１．５以下であり、より好ましくは１１以下である。そして、本発明の口腔用組成物の２５℃におけるｐＨは、７を超え１２以下であって、好ましくは８〜１１．５であり、より好ましくは８．６〜１１ある。
なお、本発明の口腔用組成物のｐＨは、ｐＨ電極を用いて２５℃で測定した値であり、本発明の口腔用組成物が歯磨組成物である場合には、イオン交換水又は蒸留水からなる精製水により１０質量％の濃度の水溶液に調整した後に測定した値を意味する。
The pH at 25 ° C. of the oral composition of the present invention ensures the stability of the component (A) and effectively suppresses the discoloration of the composition, while at the same time satisfying the fluorine ion supply effect by the component (B). From the viewpoint of aiming, it exceeds 7, preferably 8 or more, more preferably 8.6 or more. Moreover, the pH at 25 ° C. of the oral composition of the present invention is 12 or less from the viewpoint of suppressing the decrease in the fluorine ion supply effect by the component (B) and preventing the expression of harmfulness, etc. Preferably it is 11.5 or less, More preferably, it is 11 or less. And the pH in 25 degreeC of the composition for oral cavity of this invention is more than 7, 12 or less, Preferably it is 8-11.5, More preferably, it is 8.6-11.
In addition, pH of the composition for oral cavity of this invention is the value measured at 25 degreeC using the pH electrode, and when the composition for oral cavity of this invention is a dentifrice composition, ion-exchange water or distilled water Means a value measured after adjusting to an aqueous solution having a concentration of 10% by mass with purified water.
また、本発明の口腔用組成物のｐＨを上記所望の値に調整するにあたり、必要に応じてｐＨ調整剤を用いることができる。かかるｐＨ調整剤としては、例えば、酢酸、塩酸、硫酸、硝酸、クエン酸、リン酸、フィチン酸、ポリリン酸、リンゴ酸、グルコン酸、マレイン酸、コハク酸、グルタミン酸、水酸化ナトリウム、水酸化カリウム、酢酸ナトリウム、炭酸ナトリウム、炭酸水素ナトリウム、セスキ炭酸ナトリウム、クエン酸ナトリウム、クエン酸水素ナトリウム、リン酸ナトリウム、リン酸二水素ナトリウム等の酸やアルカリ、緩衝作用を有するｐＨ調整剤が挙げられる。なかでも、水酸化ナトリウム、及び緩衝作用を有するｐＨ調整剤から選ばれる１種又は２種以上が好ましく、緩衝作用を有するｐＨ調整剤がより好ましく、具体的には炭酸ナトリウム、又は炭酸水素ナトリウムから選ばれる１種又は２種がさらに好ましい。
かかるｐＨ調整剤の含有量については、その種類によっても変動し得るものであることから特に制限されず、上記ｐＨが上記所望の値を示すよう、適宜その含有量を選択して用いればよい。
Moreover, when adjusting pH of the composition for oral cavity of this invention to the said desired value, a pH adjuster can be used as needed. Examples of such pH adjusters include acetic acid, hydrochloric acid, sulfuric acid, nitric acid, citric acid, phosphoric acid, phytic acid, polyphosphoric acid, malic acid, gluconic acid, maleic acid, succinic acid, glutamic acid, sodium hydroxide, potassium hydroxide. And acid adjusters such as sodium acetate, sodium carbonate, sodium bicarbonate, sodium sesquicarbonate, sodium citrate, sodium hydrogen citrate, sodium phosphate, sodium dihydrogen phosphate, and pH adjusters having a buffering action. Among them, one or two or more kinds selected from sodium hydroxide and a pH adjusting agent having a buffering action are preferable, and a pH adjusting agent having a buffering action is more preferable, specifically, sodium carbonate or sodium bicarbonate. One or two selected are more preferable.
The content of the pH adjusting agent is not particularly limited because it may vary depending on the type of the pH adjusting agent, and the content may be appropriately selected and used so that the pH exhibits the desired value.
本発明の口腔用組成物は、次の成分（Ａ）、並びに（Ｂ）：
（Ａ）銅クロロフィリンナトリウム ０．００１質量％以上０．５質量％以下、並びに
（Ｂ）水 １０質量％以上９０質量％以下
を配合する工程（Ｉ）、
成分（Ａ）以外の銅、鉄、カルシウム、マグネシウム、アルミニウム、亜鉛、及び錫から選ばれる１種又は２種以上の多価金属又はその塩の含有量が、金属原子換算で０．０２質量％以下となるように調整する工程（II）、並びに
２５℃におけるｐＨを７より大きく１２以下に調整する工程（III）
を備える。
上記工程（II）及び工程（III）を行う順序は、特に制限されず、工程（Ｉ）を経た後、工程（II）及び工程（III）を同時におこなってもよく、または工程（III）を経たのち工程（II）を経てもよく、或いは工程（Ｉ）とともに工程（II）及び工程（III）を行ってもよい。
工程（Ｉ）における各成分の配合量は、上記各成分の含有量と同様である。また、成分（Ｃ）のフッ素イオン供給化合物を配合する場合には、かかる工程（Ｉ）において、成分（Ａ）及び（Ｂ）とともに配合すればよい。
さらに工程（III）においては、工程（Ｉ）〜工程（III）を経ることにより得られる製造時の組成物での２５℃におけるｐＨが、上記所定の範囲になるよう調整すればよく、必要に応じて上記ｐＨ調整剤を用いることもできる。
なお、工程（Ｉ）〜工程（III）を経ることにより得られる製造時での、本発明の口腔用組成物の２５℃におけるｐＨは、成分（Ａ）の安定性を確保して、組成物の変色を有効に抑制しつつ、成分（Ｂ）によるフッ素イオン供給効果との両立を図る観点から、７を超え、好ましくは８以上であり、より好ましくは８．６以上である。また、本発明の口腔用組成物の２５℃におけるｐＨは、成分（Ｂ）によるフッ素イオン供給効果の低下を抑制する観点、及び為害性等の発現を防止する観点から、１２以下であって、好ましくは１１．５以下であり、より好ましくは１１以下である。そして、本発明の口腔用組成物の２５℃におけるｐＨは、７を超え１２以下であって、好ましくは８〜１１．５であり、より好ましくは８．６〜１１ある。
The composition for oral cavity of the present invention comprises the following components (A) and (B):
(A) Copper chlorophyllin sodium 0.001% by mass or more and 0.5% by mass or less, and (B) Step of blending 10% by mass or more and 90% by mass or less of water (I),
The content of one or more polyvalent metals selected from copper, iron, calcium, magnesium, aluminum, zinc, and tin other than the component (A) or a salt thereof is 0.02% by mass in terms of metal atoms. Step (II) for adjusting to be as follows, and Step (III) for adjusting pH at 25 ° C. to greater than 7 and 12 or less
Is provided.
The order in which the step (II) and the step (III) are performed is not particularly limited, and after the step (I), the step (II) and the step (III) may be performed simultaneously, or the step (III) may be performed. After passing through step (II), step (II) and step (III) may be performed together with step (I).
The amount of each component in step (I) is the same as the content of each component. Moreover, what is necessary is just to mix | blend with a component (A) and (B) in this process (I), when mix | blending the fluorine ion supply compound of a component (C).
Furthermore, in the step (III), the pH at 25 ° C. in the composition at the time of production obtained by passing through the steps (I) to (III) may be adjusted so as to be within the above predetermined range. Depending on the above, the pH adjusting agent can be used.
In addition, pH at 25 degreeC of the composition for oral cavity of this invention at the time of manufacture obtained by passing through process (I)-process (III) ensures stability of a component (A), and is composition. From the viewpoint of coexisting with the fluorine ion supply effect by the component (B) while effectively suppressing the discoloration, the number is more than 7, preferably 8 or more, more preferably 8.6 or more. Moreover, the pH at 25 ° C. of the oral composition of the present invention is 12 or less from the viewpoint of suppressing the decrease in the fluorine ion supply effect by the component (B) and preventing the expression of harmfulness, etc. Preferably it is 11.5 or less, More preferably, it is 11 or less. And the pH in 25 degreeC of the composition for oral cavity of this invention is more than 7, 12 or less, Preferably it is 8-11.5, More preferably, it is 8.6-11.
以下、本発明について、実施例に基づき具体的に説明する。なお、表中に特に示さない限り、各成分の含有量は質量％を示す。 Hereinafter, the present invention will be specifically described based on examples. In addition, unless otherwise indicated in a table | surface, content of each component shows the mass%.
［実施例１〜２、比較例１〜２］
表１に示す処方にしたがい、各成分を配合及び混合し、必要に応じて水酸化ナトリウム又は塩酸を配合することにより、２５℃におけるｐＨを調整して、各練歯磨組成物を得た。
得られた練歯磨組成物を用い、以下の方法にしたがって、各測定及び評価を行った。
結果を表１に示す。
[Examples 1-2, Comparative Examples 1-2]
According to the formulation shown in Table 1, each component was blended and mixed, and sodium hydroxide or hydrochloric acid was blended as necessary to adjust the pH at 25 ° C. to obtain each toothpaste composition.
Each measurement and evaluation were performed according to the following method using the obtained toothpaste composition.
The results are shown in Table 1.
《ｐＨの測定》
得られた練歯磨組成物を２５℃において精製水により１０質量％の濃度の水溶液に希釈した後、ｐＨ電極を用いてかかる水溶液のｐＨを測定した。
<Measurement of pH>
The obtained toothpaste composition was diluted to an aqueous solution having a concentration of 10% by mass with purified water at 25 ° C., and then the pH of the aqueous solution was measured using a pH electrode.
《フッ素イオン濃度の測定》
得られた練歯磨組成物０．５ｇを水酸化ナトリウム試液５ｍＬを加えて沸騰浴中で２０分加熱後冷却後、過塩素酸（３０％）溶液１０ｍＬを入れ、沸騰水浴上で２０分加熱後冷却する。イオン交換水で１００ｍＬにメスアップした本溶液２０ｍＬをｐＨ８．５の緩衝液で２０ｍＬまでメスアップし、試験液とした。次いで、フッ素イオン電極（ionplus-Fluoride（ＯＲＩＯＮ社製））を用い、イオンアナライザー（Expandable ionAnalyzer EA 940（ＯＲＩＯＮ社製））を使用して、各試料中におけるフッ素イオン濃度を測定した。
<Measurement of fluorine ion concentration>
0.5 g of the obtained toothpaste composition was added with 5 mL of a sodium hydroxide test solution, heated in a boiling bath for 20 minutes, cooled, then added with 10 mL of a perchloric acid (30%) solution, and heated in a boiling water bath for 20 minutes. Cooling. 20 mL of this solution made up to 100 mL with ion-exchanged water was made up to 20 mL with a pH 8.5 buffer solution to prepare a test solution. Subsequently, the fluorine ion concentration in each sample was measured using a fluorine ion electrode (ionplus-Fluoride (made by ORION)) and an ion analyzer (Expandable ionAnalyzer EA 940 (made by ORION)).
《組成物の性状》
得られた練歯磨組成物をラミネートチューブ（容量１００ｇ）に７０ｇずつ充填し、密閉して、温度サイクル試験に供した。これは２５℃、６０℃、−１５℃、２５℃の温度変化を２４時間１サイクルとし、計１４４時間６サイクル保存するものである。保存後、各試料をイオン交換水で１０倍に希釈し、遠心分離機で１５０００ｒｐｍで１０分間遠心分離した後の組成物の性状について、析出が生じているか否か、必要に応じて沈殿物の着色も含め、目視により確認した。
続いて、かかる性状につき良好であったことが確認されたものについてのみ、以下の変色の度合いを評価した。
<Property of composition>
The obtained toothpaste composition was filled into a laminate tube (capacity 100 g) in an amount of 70 g, sealed, and subjected to a temperature cycle test. In this, temperature changes at 25 ° C., 60 ° C., −15 ° C., and 25 ° C. are defined as 24 hours and 1 cycle, and the total storage is 144 hours and 6 cycles. After storage, each sample was diluted 10 times with ion-exchanged water and centrifuged at 15000 rpm for 10 minutes with respect to the properties of the composition. It was confirmed visually, including coloring.
Subsequently, the degree of the following discoloration was evaluated only for those that were confirmed to be good for such properties.
《変色抑制効果》
得られた練歯磨組成物をラミネートチューブ（容量１００ｇ）に７０ｇずつ充填し、密閉して、先述の温度サイクル試験に供したのち、基準試料との色差を下記方法により測定し、この色差により変色の度合いを評価した。なお、基準試料として、水分量 ９９．９９質量％、銅クロロフィリンナトリウム ０．０１質量％の溶液を用いた。
具体的には、各試料を透明で内容量が３cm×３cm×１cmのケース（AS ONE社、PS CASE No.1）に詰め、一定の照明、シャッター速度、しぼり、焦点距離の撮影条件にて、白板の上で分光測色計CM−７００ｄ（コニカミノルタオプティクス株式会社）を用いて被測定部位のＬ*ａ*ｂ*（以下Ｌ、ａ、ｂとする）を定量化し、各保存後の練歯磨組成物におけるＬ、ａ、ｂと、基準試料におけるＬ、ａ、ｂの差異（ΔＥ）を下記式（Ｉ）に基づいて求め、変色度とした。
<Discoloration suppression effect>
The obtained toothpaste composition was filled into a laminate tube (capacity: 100 g) in an amount of 70 g, sealed, and subjected to the temperature cycle test described above, and then the color difference from the reference sample was measured by the following method. Was evaluated. As a reference sample, a solution having a water content of 99.99% by mass and copper chlorophyllin sodium of 0.01% by mass was used.
Specifically, each sample is packed in a transparent case with an internal volume of 3cm x 3cm x 1cm (AS ONE, PS CASE No. 1), under certain lighting, shutter speed, aperture, and focal length shooting conditions. Then, L * a * b * (hereinafter referred to as L, a, b) of the measurement site was quantified using a spectrocolorimeter CM-700d (Konica Minolta Optics Co., Ltd.) on a white plate, and after each storage A difference (ΔE) between L, a, and b in the toothpaste composition and L, a, and b in the reference sample was determined based on the following formula (I), and was defined as the degree of discoloration.
Ｘ＝〔(Ｌ0−Ｌ1)2＋(ａ0−ａ1)2＋(ｂ0−ｂ1)2〕
変色度（ΔＥ）＝Ｘ1/2 ・・・（Ｉ）
〔Ｌ0、ａ0及びｂ0は、それぞれ標準品におけるＬ、ａ及びｂを示し、Ｌ1、ａ1及びｂ1は、それぞれ温度サイクル試験保存品におけるＬ、ａ及びｂを示す。〕
X = [(L 0 −L 1 ) 2 + (a 0 −a 1 ) 2 + (b 0 −b 1 ) 2 ]
Discoloration degree (ΔE) = X 1/2 (I)
[L 0 , a 0 and b 0 represent L, a and b in the standard product, respectively, and L 1 , a 1 and b 1 represent L, a and b in the temperature cycle test storage product, respectively. ]
次いで、得られた変色度（ΔＥ）の値から、下記基準にしたがって変色の抑制効果を評価した。値が小さいほど、効果的に変色が抑制されて、成分（Ａ）の銅クロロフィリンナトリウムの安定性が高められていることを意味する。
ＡＡ：ΔＥ＝１４．０未満
Ａ ：ΔＥ＝１４．０以上１７．０未満
Ｂ ：ΔＥ＝１７．０以上２０．０未満
Ｃ ：ΔＥ＝２０．０以上
Next, from the obtained color change degree (ΔE) value, the effect of suppressing color change was evaluated according to the following criteria. A smaller value means that discoloration is effectively suppressed and the stability of the copper chlorophyllin sodium component (A) is enhanced.
AA: ΔE = 14.0 or less A: ΔE = 14.0 or more and less than 17.0 B: ΔE = 17.0 or more and less than 20.0 C: ΔE = 20.0 or more
［実施例３〜１０、比較例３〜８］
表２に示す処方にしたがい、各成分を配合及び混合し、必要に応じて水酸化ナトリウム、炭酸水素ナトリウム、炭酸ナトリウム、塩酸を配合することにより、２５℃におけるｐＨを調整して、各液体口腔用組成物を得た。
得られた液体口腔用組成物を用い、以下の方法にしたがって、各測定及び評価を行った。なお、フッ素イオン濃度の測定については、実施例１と同様に行い、ｐＨの測定については、液体口腔用組成物を希釈することなくそのまま用いて、実施例１と同様にして行った。
結果を表２に示す。
[Examples 3 to 10, Comparative Examples 3 to 8]
In accordance with the formulation shown in Table 2, each component is blended and mixed, and if necessary, sodium hydroxide, sodium bicarbonate, sodium carbonate, hydrochloric acid is blended to adjust the pH at 25 ° C., and each liquid oral cavity A composition was obtained.
Each measurement and evaluation were performed according to the following method using the obtained composition for liquid oral cavity. The measurement of fluorine ion concentration was performed in the same manner as in Example 1. The measurement of pH was performed in the same manner as in Example 1, using the liquid oral composition without dilution.
The results are shown in Table 2.
《フッ素イオン濃度の測定》
フッ素イオン電極（ionplus-Fluoride（ＯＲＩＯＮ社製））を用い、イオンアナライザー（Expandable ionAnalyzer EA 940（ＯＲＩＯＮ社製））を使用して、得られた液体口腔用組成物中におけるフッ素イオン濃度を測定した。
<Measurement of fluorine ion concentration>
Using a fluorine ion electrode (ionplus-Fluoride (made by ORION)) and using an ion analyzer (Expandable ionAnalyzer EA 940 (made by ORION)), the fluorine ion concentration in the obtained liquid oral composition was measured. .
《組成物の性状》
得られた液体口腔用組成物をガラス容器（容量：５５ｍｌ）に４０ｇずつ充填し、密閉して、温度サイクル試験に供した。これは２５℃、６０℃、−１５℃、２５℃の温度変化を２４時間１サイクルとし、計１４４時間６サイクル保存するものである。保存後、各試料の組成物の性状について、液分離が生じているか否か、必要に応じて沈殿物の着色も含め、目視により確認した。
続いて、かかる性状につき良好であったことが確認されたものについてのみ、以下の変色の度合いを評価した。
<Property of composition>
The obtained liquid oral cavity composition was filled into a glass container (capacity: 55 ml) by 40 g, sealed, and subjected to a temperature cycle test. In this, temperature changes at 25 ° C., 60 ° C., −15 ° C., and 25 ° C. are defined as 24 hours and 1 cycle, and the total storage is 144 hours and 6 cycles. After storage, the properties of the compositions of each sample were confirmed by visual observation as to whether liquid separation occurred or not, including coloring of precipitates as necessary.
Subsequently, the degree of the following discoloration was evaluated only for those that were confirmed to be good for such properties.
《変色抑制効果》
得られた液体口腔用組成物をガラス容器（容量：５５ｍｌ）に４０ｇずつ充填し、密閉して、先述の温度サイクル試験に供したのち、基準試料との色差を下記方法により測定し、この色差により変色の度合いを評価した。なお、基準試料として、水分量 ９９．９９質量％、銅クロロフィリンナトリウム ０．０１質量％の溶液を用いた。
具体的には、各試料を透明で内容量が３cm×３cm×１cmのケース（AS ONE社、PS CASE No.1）に詰め、一定の照明、シャッター速度、しぼり、焦点距離の撮影条件にて、白板の上で撮影を行った。撮影した画像からADOBE PHOTOSHOP（登録商標）を用いて被測定部位のＬ*ａ*ｂ*（以下Ｌ、ａ、ｂとする）を定量化し、各保存後の練歯磨組成物におけるＬ、ａ、ｂと、基準試料におけるＬ、ａ、ｂの差異（ΔＥ）を下記式（Ｉ）に基づいて求め、変色度とした。
<Discoloration suppression effect>
The obtained liquid oral composition was filled into a glass container (capacity: 55 ml) in an amount of 40 g, sealed, and subjected to the temperature cycle test described above, and then the color difference from the reference sample was measured by the following method. Thus, the degree of discoloration was evaluated. As a reference sample, a solution having a water content of 99.99% by mass and copper chlorophyllin sodium of 0.01% by mass was used.
Specifically, each sample is packed in a transparent case with an internal volume of 3cm x 3cm x 1cm (AS ONE, PS CASE No. 1), under certain lighting, shutter speed, aperture, and focal length shooting conditions. I took a photo on a white board. L * a * b * (hereinafter referred to as L, a, b) of the measurement site is quantified using ADOBE PHOTOSHOP (registered trademark) from the photographed image, and L, a, The difference (ΔE) between b and L, a, and b in the reference sample was determined based on the following formula (I), and was defined as the degree of discoloration.
Ｘ＝〔(Ｌ0−Ｌ1)2＋(ａ0−ａ1)2＋(ｂ0−ｂ1)2〕
変色度（ΔＥ）＝Ｘ1/2 ・・・（Ｉ）
〔Ｌ0、ａ0及びｂ0は、それぞれ標準品におけるＬ、ａ及びｂを示し、Ｌ1、ａ1及びｂ1は、それぞれ温度サイクル試験保存品におけるＬ、ａ及びｂを示す。〕
X = [(L 0 −L 1 ) 2 + (a 0 −a 1 ) 2 + (b 0 −b 1 ) 2 ]
Discoloration degree (ΔE) = X 1/2 (I)
[L 0 , a 0 and b 0 represent L, a and b in the standard product, respectively, and L 1 , a 1 and b 1 represent L, a and b in the temperature cycle test storage product, respectively. ]
次いで、得られた変色度（ΔＥ）の値から、下記基準にしたがって変色の抑制効果を評価した。値が小さいほど、効果的に変色が抑制されて、成分（Ａ）の銅クロロフィリンナトリウムの安定性が高められていることを意味する。
ＡＡ：ΔＥ＝５．５未満
Ａ ：ΔＥ＝５．５以上７．０未満
Ｂ ：ΔＥ＝７．０以上９．０未満
Ｃ ：ΔＥ＝９．０以上
Next, from the obtained color change degree (ΔE) value, the effect of suppressing color change was evaluated according to the following criteria. A smaller value means that discoloration is effectively suppressed and the stability of the copper chlorophyllin sodium component (A) is enhanced.
AA: ΔE = less than 5.5 A: ΔE = 5.5 or more and less than 7.0 B: ΔE = 7.0 or more and less than 9.0 C: ΔE = 9.0 or more
Claims (6)
（Ａ）銅クロロフィリンナトリウム、及び鉄クロロフィリンナトリウムから選ばれる１種以上のクロロフィル化合物 ０．００１質量％以上０．５質量％以下、並びに
（Ｂ）水 １０質量％以上９０質量％以下
を含有し、２５℃におけるｐＨが７を超え１２以下であり、かつ
成分（Ａ）以外の銅、鉄、カルシウム、マグネシウム、アルミニウム、亜鉛、及び錫から選ばれる１種又は２種以上の多価金属又はその塩の含有量が、金属原子換算量で０．０２質量％以下である口腔用組成物。 The following components (A) and (B):
(A) One or more chlorophyll compounds selected from copper chlorophyllin sodium and iron chlorophyllin sodium 0.001% by mass to 0.5% by mass, and (B) water 10% by mass to 90% by mass, 1 or 2 or more types of polyvalent metals or salts thereof whose pH at 25 ° C. is more than 7 and 12 or less, and selected from copper, iron, calcium, magnesium, aluminum, zinc, and tin other than component (A) The composition for oral cavity whose content is 0.02 mass% or less in terms of metal atom.
（Ａ）銅クロロフィリンナトリウム及び鉄クロロフィリンナトリウムから選ばれる１種以上のクロロフィル化合物 ０．００１質量％以上０．５質量％以下、並びに
（Ｂ）水 １０質量％以上９０質量％以下
を配合する工程（Ｉ）、
成分（Ａ）以外の銅、鉄、カルシウム、マグネシウム、アルミニウム、亜鉛、及び錫から選ばれる１種又は２種以上の多価金属又はその塩の含有量が、金属原子換算で０．０２質量％以下となるように調整する工程（II）、並びに
２５℃におけるｐＨを７より大きく１２以下に調整する工程（III）
を備える口腔用組成物の製造方法。 The following components (A) and (B):
(A) One or more chlorophyll compounds selected from copper chlorophyllin sodium and iron chlorophyllin sodium 0.001% by mass to 0.5% by mass, and (B) water 10% by mass to 90% by mass I),
The content of one or more polyvalent metals selected from copper, iron, calcium, magnesium, aluminum, zinc, and tin other than the component (A) or a salt thereof is 0.02% by mass in terms of metal atoms. Step (II) for adjusting to be as follows, and Step (III) for adjusting pH at 25 ° C. to greater than 7 and 12 or less
The manufacturing method of the composition for oral cavity provided with.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10588875B2 (en) | 2015-11-09 | 2020-03-17 | Kao Corporation | Oral composition |
| CN111867550A (en) * | 2018-05-29 | 2020-10-30 | 狮王株式会社 | Oral composition |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002003365A (en) * | 2000-04-21 | 2002-01-09 | Eisai Co Ltd | Liquid medicine composition including salt of copper chlorophyllin |
| JP2003192555A (en) * | 2001-12-25 | 2003-07-09 | Lion Corp | Dentifrice composition |
| JP2006219418A (en) * | 2005-02-10 | 2006-08-24 | Earth Chem Corp Ltd | Liquid composition for oral cavity |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002003365A (en) * | 2000-04-21 | 2002-01-09 | Eisai Co Ltd | Liquid medicine composition including salt of copper chlorophyllin |
| JP2003192555A (en) * | 2001-12-25 | 2003-07-09 | Lion Corp | Dentifrice composition |
| JP2006219418A (en) * | 2005-02-10 | 2006-08-24 | Earth Chem Corp Ltd | Liquid composition for oral cavity |
Non-Patent Citations (1)
| Title |
|---|
| KAO DEEP CLEAN SEN: "Rich Cream Medicated Toothpaste", MINTEL GNPD, JPN6020003030, December 2016 (2016-12-01), ISSN: 0004204171 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10588875B2 (en) | 2015-11-09 | 2020-03-17 | Kao Corporation | Oral composition |
| CN111867550A (en) * | 2018-05-29 | 2020-10-30 | 狮王株式会社 | Oral composition |
| CN111867550B (en) * | 2018-05-29 | 2023-04-14 | 狮王株式会社 | Oral composition |
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