JP2016190817A - External composition - Google Patents
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- JP2016190817A JP2016190817A JP2015072192A JP2015072192A JP2016190817A JP 2016190817 A JP2016190817 A JP 2016190817A JP 2015072192 A JP2015072192 A JP 2015072192A JP 2015072192 A JP2015072192 A JP 2015072192A JP 2016190817 A JP2016190817 A JP 2016190817A
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- weight
- fatty acid
- acid ester
- ceramides
- oil
- Prior art date
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- Granted
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- 239000000203 mixture Substances 0.000 title claims abstract description 54
- 229940106189 ceramide Drugs 0.000 claims abstract description 43
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 40
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 40
- 229930195729 fatty acid Natural products 0.000 claims abstract description 40
- 239000000194 fatty acid Substances 0.000 claims abstract description 40
- -1 glycerine fatty acid ester Chemical class 0.000 claims abstract description 38
- 235000011187 glycerol Nutrition 0.000 claims abstract description 36
- 150000001783 ceramides Chemical class 0.000 claims abstract description 34
- 239000007787 solid Substances 0.000 claims abstract description 20
- 239000010685 fatty oil Substances 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 9
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 9
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 9
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 9
- 239000003921 oil Substances 0.000 description 9
- 235000019198 oils Nutrition 0.000 description 9
- 150000004665 fatty acids Chemical class 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 6
- 210000003491 skin Anatomy 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- MIUIRGGKIICMBP-NFOZDHADSA-N [27-oxo-27-[[(2s,3s,4r)-1,3,4-trihydroxyoctadecan-2-yl]amino]heptacosyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC MIUIRGGKIICMBP-NFOZDHADSA-N 0.000 description 5
- 150000002148 esters Chemical group 0.000 description 5
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 4
- ATGQXSBKTQANOH-UWVGARPKSA-N N-oleoylphytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCC\C=C/CCCCCCCC ATGQXSBKTQANOH-UWVGARPKSA-N 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 229940048864 ceramide 1 Drugs 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 230000003020 moisturizing effect Effects 0.000 description 4
- 239000001993 wax Substances 0.000 description 4
- 235000018330 Macadamia integrifolia Nutrition 0.000 description 3
- 240000000912 Macadamia tetraphylla Species 0.000 description 3
- 235000003800 Macadamia tetraphylla Nutrition 0.000 description 3
- KZTJQXAANJHSCE-OIDHKYIRSA-N N-octodecanoylsphinganine Chemical compound CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)CCCCCCCCCCCCCCC KZTJQXAANJHSCE-OIDHKYIRSA-N 0.000 description 3
- 229940099417 ceramide 2 Drugs 0.000 description 3
- 229940044176 ceramide 3 Drugs 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000010466 nut oil Substances 0.000 description 3
- 235000002378 plant sterols Nutrition 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 240000001238 Gaultheria procumbens Species 0.000 description 2
- 235000007297 Gaultheria procumbens Nutrition 0.000 description 2
- 235000019487 Hazelnut oil Nutrition 0.000 description 2
- 239000004166 Lanolin Substances 0.000 description 2
- BBAFBDLICMHBNU-MFZOPHKMSA-N N-(2-hydroxyoctadecanoyl)-4-hydroxysphinganine Chemical compound CCCCCCCCCCCCCCCCC(O)C(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC BBAFBDLICMHBNU-MFZOPHKMSA-N 0.000 description 2
- 235000010394 Solidago odora Nutrition 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 230000001153 anti-wrinkle effect Effects 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 239000004203 carnauba wax Substances 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 239000003240 coconut oil Substances 0.000 description 2
- 235000019864 coconut oil Nutrition 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 2
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 235000019197 fats Nutrition 0.000 description 2
- 239000010468 hazelnut oil Substances 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 235000019388 lanolin Nutrition 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- 239000004006 olive oil Substances 0.000 description 2
- 235000008390 olive oil Nutrition 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000008247 solid mixture Substances 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 235000020238 sunflower seed Nutrition 0.000 description 2
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 2
- WWUZIQQURGPMPG-UHFFFAOYSA-N (-)-D-erythro-Sphingosine Natural products CCCCCCCCCCCCCC=CC(O)C(N)CO WWUZIQQURGPMPG-UHFFFAOYSA-N 0.000 description 1
- KZJWDPNRJALLNS-VPUBHVLGSA-N (-)-beta-Sitosterol Natural products O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@@](C)([C@H]([C@H](CC[C@@H](C(C)C)CC)C)CC4)CC3)CC=2)CC1 KZJWDPNRJALLNS-VPUBHVLGSA-N 0.000 description 1
- CSVWWLUMXNHWSU-UHFFFAOYSA-N (22E)-(24xi)-24-ethyl-5alpha-cholest-22-en-3beta-ol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(CC)C(C)C)C1(C)CC2 CSVWWLUMXNHWSU-UHFFFAOYSA-N 0.000 description 1
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical compound C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 description 1
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- DGSZGZSCHSQXFV-UHFFFAOYSA-N 2,3-bis(2-ethylhexanoyloxy)propyl 2-ethylhexanoate Chemical compound CCCCC(CC)C(=O)OCC(OC(=O)C(CC)CCCC)COC(=O)C(CC)CCCC DGSZGZSCHSQXFV-UHFFFAOYSA-N 0.000 description 1
- XULHFMYCBKQGEE-UHFFFAOYSA-N 2-hexyl-1-Decanol Chemical compound CCCCCCCCC(CO)CCCCCC XULHFMYCBKQGEE-UHFFFAOYSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- KLEXDBGYSOIREE-UHFFFAOYSA-N 24xi-n-propylcholesterol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CCC)C(C)C)C1(C)CC2 KLEXDBGYSOIREE-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 1
- 241000283153 Cetacea Species 0.000 description 1
- LPZCCMIISIBREI-MTFRKTCUSA-N Citrostadienol Natural products CC=C(CC[C@@H](C)[C@H]1CC[C@H]2C3=CC[C@H]4[C@H](C)[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)C LPZCCMIISIBREI-MTFRKTCUSA-N 0.000 description 1
- AERBNCYCJBRYDG-UHFFFAOYSA-N D-ribo-phytosphingosine Natural products CCCCCCCCCCCCCCC(O)C(O)C(N)CO AERBNCYCJBRYDG-UHFFFAOYSA-N 0.000 description 1
- ARVGMISWLZPBCH-UHFFFAOYSA-N Dehydro-beta-sitosterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)CCC(CC)C(C)C)CCC33)C)C3=CC=C21 ARVGMISWLZPBCH-UHFFFAOYSA-N 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- WAYLDHLWVYQNSQ-KEFDUYNTSA-N N-2-hydroxylignoceroylsphingosine Chemical compound CCCCCCCCCCCCCCCCCCCCCCC(O)C(=O)N[C@@H](CO)[C@H](O)\C=C\CCCCCCCCCCCCC WAYLDHLWVYQNSQ-KEFDUYNTSA-N 0.000 description 1
- IEZRNEGTKRQRFV-LFBNJJMOSA-N N-octadecanoyl-4-hydroxysphinganine Chemical compound CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC IEZRNEGTKRQRFV-LFBNJJMOSA-N 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- ZGBFGAHZKZQSLG-UMCOJZBLSA-N [30-oxo-30-[[(e,2s,3r,6r)-1,3,6-trihydroxyoctadec-4-en-2-yl]amino]triacontyl] (9z,12z)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCC[C@@H](O)\C=C\[C@@H](O)[C@H](CO)NC(=O)CCCCCCCCCCCCCCCCCCCCCCCCCCCCCOC(=O)CCCCCCC\C=C/C\C=C/CCCCC ZGBFGAHZKZQSLG-UMCOJZBLSA-N 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000012164 animal wax Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 229940064004 antiseptic throat preparations Drugs 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- MJVXAPPOFPTTCA-UHFFFAOYSA-N beta-Sistosterol Natural products CCC(CCC(C)C1CCC2C3CC=C4C(C)C(O)CCC4(C)C3CCC12C)C(C)C MJVXAPPOFPTTCA-UHFFFAOYSA-N 0.000 description 1
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 description 1
- NJKOMDUNNDKEAI-UHFFFAOYSA-N beta-sitosterol Natural products CCC(CCC(C)C1CCC2(C)C3CC=C4CC(O)CCC4C3CCC12C)C(C)C NJKOMDUNNDKEAI-UHFFFAOYSA-N 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 229960004203 carnitine Drugs 0.000 description 1
- 239000012185 ceresin wax Substances 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 229960000735 docosanol Drugs 0.000 description 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 150000004667 medium chain fatty acids Chemical class 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000012184 mineral wax Substances 0.000 description 1
- 229940043348 myristyl alcohol Drugs 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 229960002446 octanoic acid Drugs 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- AERBNCYCJBRYDG-KSZLIROESA-N phytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO AERBNCYCJBRYDG-KSZLIROESA-N 0.000 description 1
- 229940033329 phytosphingosine Drugs 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 239000012165 plant wax Substances 0.000 description 1
- 229920000223 polyglycerol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 229940109850 royal jelly Drugs 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 1
- 235000015500 sitosterol Nutrition 0.000 description 1
- 229950005143 sitosterol Drugs 0.000 description 1
- NLQLSVXGSXCXFE-UHFFFAOYSA-N sitosterol Natural products CC=C(/CCC(C)C1CC2C3=CCC4C(C)C(O)CCC4(C)C3CCC2(C)C1)C(C)C NLQLSVXGSXCXFE-UHFFFAOYSA-N 0.000 description 1
- WWUZIQQURGPMPG-KRWOKUGFSA-N sphingosine Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
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Landscapes
- Cosmetics (AREA)
Abstract
Description
本発明は、セラミド類を高濃度で含有する固形状の外用組成物に関する。 The present invention relates to a solid external composition containing ceramides at a high concentration.
セラミド類は、人の皮膚（角層）に存在する細胞間脂質であって、加齢等により角層内のセラミドは減少していくことが知られている。それに伴い皮膚は乾燥して皺などを生じ、またバリア機能の低下によってアレルゲン等の侵入を招き、炎症やかゆみを生じることになる。このような症状に対して、セラミドを外用することが有効であって、その際セラミドを溶解状態にすることにより対象部位への浸透を図ることができる。また、濃度依存性があるためできるだけ高濃度で含有させ、持続力の観点から製剤の性状は固形状であることが好ましい。 Ceramides are intercellular lipids present in human skin (stratum corneum), and it is known that ceramide in the stratum corneum decreases with aging and the like. Along with this, the skin is dried to cause wrinkles and the like, and due to the lowered barrier function, allergens and the like are invaded, causing inflammation and itching. For such symptoms, it is effective to apply ceramide externally, and in that case, penetration into the target site can be achieved by bringing ceramide into a dissolved state. Moreover, since it has concentration dependency, it is preferably contained at a concentration as high as possible. From the viewpoint of sustainability, it is preferable that the properties of the preparation are solid.
しかしながら、セラミド類は基剤に分散、可溶化させることが技術的に難しく、固形状（スティック状）の製剤とした場合に適切な硬度が得られず、使用感が悪くなるという問題があった。また、セラミド類を高濃度で配合すると、この傾向は顕著になるため、セラミド類を高濃度で配合し、適切な硬度を保つことは非常に困難であった。 However, it is technically difficult to disperse and solubilize ceramides in the base material, and there is a problem that when a solid (stick-like) preparation is obtained, appropriate hardness cannot be obtained and the usability is deteriorated. . Moreover, since this tendency becomes remarkable when ceramides are blended at a high concentration, it is very difficult to blend ceramides at a high concentration and maintain an appropriate hardness.
たとえば特許文献１では、脂肪酸トリグリセリドおよびフィトステロール誘導体を含む組成物が提案され、特許文献２では、ポリグリセリン脂肪酸エステルおよび脂肪酸モノグリセリドを含む組成物が提案されている。しかしながら、これらの組成物は、いずれも液状組成物に関するものであって固形状の外用組成物ではなく、また、文献で具体的に開示されている組成物ではセラミド類の濃度は非常に低いものであった。 For example, Patent Document 1 proposes a composition containing a fatty acid triglyceride and a phytosterol derivative, and Patent Document 2 proposes a composition containing a polyglycerol fatty acid ester and a fatty acid monoglyceride. However, these compositions are all related to liquid compositions and are not solid external compositions, and in the compositions specifically disclosed in the literature, the concentration of ceramides is very low. Met.
本発明は、セラミド類を高濃度で含有するにもかかわらず、均一で安定性の高い固形状の外用組成物を提供することを目的とする。 It is an object of the present invention to provide a solid external composition that is uniform and highly stable despite containing a high concentration of ceramides.
本発明者らは、セラミド類の高濃度化について鋭意研究したところ、（Ａ）セラミド類を４〜１２重量％含有する固形状の外用組成物において、硬度のコントロールが難しいという問題に対して、（Ｂ）グリセリン脂肪酸エステルと（Ｃ）脂肪油を特定量含有することにより、適度な硬度を有する固形状の外用組成物とすることができることを見出し、本発明を完成した。 As a result of diligent research on increasing the concentration of ceramides, the present inventors, in a solid external composition containing 4 to 12% by weight of (A) ceramides, for the problem that it is difficult to control the hardness, It has been found that by containing a specific amount of (B) glycerin fatty acid ester and (C) fatty oil, a solid external composition having an appropriate hardness can be obtained, and the present invention has been completed.
すなわち、本発明は、（Ａ）セラミド類４〜１２重量％、（Ｂ）グリセリン脂肪酸エステル、および、（Ｃ）脂肪油を含有し、（Ａ）セラミド類１重量部に対し、（Ｂ）グリセリン脂肪酸エステルを２重量部以上、（Ｂ）グリセリン脂肪酸エステルおよび（Ｃ）脂肪油を合計で６重量部以上含有する固形状の外用組成物に関する。 That is, the present invention comprises (A) ceramides 4 to 12% by weight, (B) glycerin fatty acid ester, and (C) fatty oil, and (B) glycerin relative to 1 part by weight of (A) ceramides. The present invention relates to a solid external composition containing 2 parts by weight or more of fatty acid ester and 6 parts by weight or more in total of (B) glycerin fatty acid ester and (C) fatty oil.
（Ｂ）グリセリン脂肪酸エステルが、グリセリン中鎖脂肪酸エステルであることが好ましい。 (B) The glycerin fatty acid ester is preferably a glycerin medium chain fatty acid ester.
（Ａ）セラミド類１重量部に対し（Ｂ）グリセリン脂肪酸エステルを５重量部以上含有することが好ましい。 (A) It is preferable to contain 5 parts by weight or more of (B) glycerin fatty acid ester with respect to 1 part by weight of ceramides.
実質的に水を含有しないことが好ましい。 It is preferable that it does not contain water substantially.
本発明によれば、（Ａ）セラミド類４〜１２重量％含有する固形状の外用組成物において、（Ａ）セラミド類１重量部に対し、（Ｂ）グリセリン脂肪酸エステルを２重量部以上、（Ｂ）グリセリン脂肪酸エステル、および、（Ｃ）脂肪油を合計で６重量部以上含有することで、セラミド類を高濃度で含有するにもかかわらず、硬度のコントロールが非常に容易な固形状の外用組成物を提供することができる。 According to the present invention, (A) in a solid external composition containing 4 to 12% by weight of ceramides, (A) 2 parts by weight or more of (B) glycerin fatty acid ester with respect to 1 part by weight of ceramides ( B) A solid external use that contains 6 parts by weight or more of glycerin fatty acid ester and (C) fatty oil in total, and is very easy to control the hardness despite containing a high concentration of ceramides. A composition can be provided.
本発明の固形状の外用組成物は、（Ａ）セラミド類４〜１２重量％、（Ｂ）グリセリン脂肪酸エステル、および、（Ｃ）脂肪油を含有し、（Ａ）セラミド類１重量部に対し、（Ｂ）グリセリン脂肪酸エステルを２重量部以上、（Ｂ）グリセリン脂肪酸エステルおよび（Ｃ）脂肪油を合計で６重量部以上含有することを特徴とする。 The solid composition for external use of the present invention contains (A) ceramides 4 to 12% by weight, (B) glycerin fatty acid ester, and (C) fatty oil, and (A) 1 part by weight of ceramides (B) 2 parts by weight or more of glycerin fatty acid ester and (B) glycerin fatty acid ester and (C) fatty oil in total 6 parts by weight or more.
（Ａ）セラミド類とは、スフィンゴシン又はフィトスフィンゴシン等のスフィンゴシンの類似塩基を中心の骨格とし、アミド結合により、ＯＨをもたない脂肪酸、α−ヒドロキシ脂肪酸又はω−ヒドロキシ脂肪酸と結合している化合物である。人の皮膚（角質）に存在する細胞間脂質を構成する成分であって、保湿性向上やバリア機能向上のために外用される。 (A) Ceramides are compounds that have a sphingosine-like base such as sphingosine or phytosphingosine as the central skeleton, and are bonded to fatty acids that do not have OH, α-hydroxy fatty acids, or ω-hydroxy fatty acids by amide bonds It is. It is a component that constitutes intercellular lipid present in human skin (keratin), and is used externally for improving moisture retention and improving barrier function.
（Ａ）セラミド類としては、合成型、天然型等の由来を問わないが、天然又は天然型セラミドが望ましい。例えば、セラミド１（セラミドＩ）、セラミド２（セラミドＩＩ）、セラミド３（セラミドＩＩＩ）、セラミド４（セラミドＩＶ）、セラミド５（セラミドＶ）、セラミド６（セラミドＶＩ）等を挙げることができる。これらの中では、抗しわ効果や保湿性等の有効性の点で、セラミド１、セラミド２およびセラミド３が好ましい。これらのセラミド類は、１種単独でも、２種以上を組み合わせて使用することもできる。 (A) The ceramides may be derived from synthetic or natural types, but natural or natural ceramides are preferred. Examples thereof include ceramide 1 (ceramide I), ceramide 2 (ceramide II), ceramide 3 (ceramide III), ceramide 4 (ceramide IV), ceramide 5 (ceramide V), and ceramide 6 (ceramide VI). Among these, ceramide 1, ceramide 2 and ceramide 3 are preferable in terms of effectiveness such as an anti-wrinkle effect and moisture retention. These ceramides can be used alone or in combination of two or more.
（Ａ）セラミド類の含有量は、外用組成物中４〜１２重量％であるが、５〜１０重量％が好ましい。４重量％未満では、使用者の満足度が充分ではない組成物となる傾向があり、１２重量％を超えると、所望の硬度が得られない傾向がある。 (A) Content of ceramides is 4-12 weight% in an external composition, However, 5-10 weight% is preferable. If the amount is less than 4% by weight, the composition tends to have insufficient user satisfaction. If the amount exceeds 12% by weight, the desired hardness tends not to be obtained.
（Ｂ）グリセリン脂肪酸エステルとは、グリセリンと脂肪酸のエステルである。グリセリン脂肪酸エステルとしては、グリセリン長鎖脂肪酸エステルまたはグリセリン中鎖脂肪酸エステルが好ましく、中でも、硬度のコントロールの容易さの点で、グリセリン中鎖脂肪酸エステルが更に好ましい。ここで中鎖脂肪酸とは炭素数が５〜１２の脂肪酸をいう。例えば、トリ（カプリル酸／カプリン酸）グリセリル、トリエチルヘキサノインなどを用いることができる。これらのグリセリン脂肪酸エステルは、1種単独でも、２種以上を組み合わせて使用することもできる。 (B) Glycerin fatty acid ester is an ester of glycerin and fatty acid. As the glycerin fatty acid ester, glycerin long-chain fatty acid ester or glycerin medium-chain fatty acid ester is preferable, and among them, glycerin medium-chain fatty acid ester is more preferable from the viewpoint of easy control of hardness. Here, the medium chain fatty acid means a fatty acid having 5 to 12 carbon atoms. For example, tri (caprylic acid / capric acid) glyceryl, triethylhexanoin, or the like can be used. These glycerin fatty acid esters can be used alone or in combination of two or more.
（Ｂ）グリセリン脂肪酸エステルの含有量は、外用組成物中１０〜７４重量％が好ましく、２５〜７４重量％がより好ましい。１０重量％未満では、所望の硬度が得られない傾向があり、７４重量％を超えると、使用者の満足度が充分ではない組成物となる傾向がある。 (B) 10-74 weight% is preferable in a composition for external use, and, as for content of glycerol fatty acid ester, 25-74 weight% is more preferable. If the amount is less than 10% by weight, the desired hardness tends not to be obtained. If the amount exceeds 74% by weight, the composition tends to have insufficient user satisfaction.
（Ｂ）グリセリン脂肪酸エステルの含有量は、（Ａ）セラミド類１重量部に対し、２重量部以上であるが、５重量部以上が好ましい。２重量部未満では、所望の硬度が得られない傾向がある。上限は特に限定されないが、１８．５重量部以下が好ましく、１５重量部以下がより好ましい。１８．５重量部を超えると、使用者の満足度が充分ではない組成物となる傾向がある。 The content of (B) glycerin fatty acid ester is 2 parts by weight or more with respect to 1 part by weight of (A) ceramides, but preferably 5 parts by weight or more. If it is less than 2 parts by weight, the desired hardness tends not to be obtained. Although an upper limit is not specifically limited, 18.5 weight part or less is preferable and 15 weight part or less is more preferable. If it exceeds 18.5 parts by weight, the composition tends to be insufficient in user satisfaction.
（Ｃ）脂肪油とは、油脂のなかで常温で液状の油である。たとえば、オリーブ油、マカデミアナッツ油、山茶花油、椿油、トウモロコシ油、ごま油、ホホバ油、サフラワー油、ヒマワリ種子油、ヘーゼルナッツ油、ユチャ油などの植物油が挙げられる。中でも、組成物の性状や使用感の点で、オリーブ油、マカデミアナッツ油、山茶花油、椿油、ヒマワリ種子油、ヘーゼルナッツ油、ユチャ油などが好ましい。これらの脂肪油は、１種単独でも、２種以上を組み合わせて使用することもできる。 (C) Fat oil is oil that is liquid at room temperature among fats and oils. Examples include vegetable oils such as olive oil, macadamia nut oil, mountain tea flower oil, coconut oil, corn oil, sesame oil, jojoba oil, safflower oil, sunflower seed oil, hazelnut oil, yucha oil. Of these, olive oil, macadamia nut oil, mountain tea flower oil, coconut oil, sunflower seed oil, hazelnut oil, yucha oil and the like are preferable from the viewpoint of the properties and feeling of use of the composition. These fatty oils can be used singly or in combination of two or more.
（Ｃ）脂肪油の含有量は、外用組成物中１５〜７８重量％が好ましく、１５〜７３重量％がより好ましい。１５重量％未満、７８重量％を超える量であると、所望の硬度が得られない傾向がある。 (C) 15-78 weight% is preferable in an external composition, and, as for content of a fatty oil, 15-73 weight% is more preferable. If the amount is less than 15% by weight or more than 78% by weight, the desired hardness tends not to be obtained.
（Ｂ）グリセリン脂肪酸エステルおよび（Ｃ）脂肪油の合計含有量は、（Ａ）セラミド類１重量部に対し、６重量部以上が好ましく、７重量部以上がより好ましい。６重量部未満では、所望の硬度が得られない傾向にある。上限は特に限定されないが、２５重量部以下が好ましく、２２．３重量部以下がより好ましい。２５重量部を超えると、使用者の満足度が充分でない組成物となる傾向がある。 The total content of (B) glycerin fatty acid ester and (C) fatty oil is preferably 6 parts by weight or more and more preferably 7 parts by weight or more with respect to 1 part by weight of (A) ceramides. If it is less than 6 parts by weight, the desired hardness tends not to be obtained. Although an upper limit is not specifically limited, 25 weight part or less is preferable and 22.3 weight part or less is more preferable. If it exceeds 25 parts by weight, the composition tends to be insufficient in user satisfaction.
本発明の固形状の外用組成物は、実質的に水を含有しないことが好ましい。実質的に水を含有しないとは、全く水を含まないことではなく、水の含有量が外用組成物中５重量％以下、好ましくは １重量％以下であればよい。 The solid external composition of the present invention preferably contains substantially no water. The phrase “substantially not containing water” does not mean that water is not contained at all, and the content of water may be 5% by weight or less, preferably 1% by weight or less in the composition for external use.
本発明の外用組成物は、前述する成分以外に、本発明の効果を損なわない範囲で、当該技術分野で通常使用されるその他の成分を含有していてもよい。このような成分としては、例えば、防腐剤、殺菌剤、抗菌剤、消炎剤、湿潤剤、賦形剤、香料、清涼化剤、色素、界面活性剤、ｐＨ調整剤、保湿剤等が挙げられる。 The composition for external use of this invention may contain the other component normally used in the said technical field in the range which does not impair the effect of this invention other than the component mentioned above. Examples of such components include antiseptics, bactericides, antibacterial agents, anti-inflammatory agents, wetting agents, excipients, fragrances, refreshing agents, dyes, surfactants, pH adjusting agents, moisturizing agents and the like. .
また本発明の外用組成物剤には、必要に応じて、本発明の効果を損なわない範囲で、セラミド以外の生理活性成分や薬理活性成分を配合することもできる。このような成分としてば、ビタミン類、アミノ酸やその重合物（ペプチド、蛋白質）、ポリフェノール、植物エキス、ローヤルゼリー、タンパク質、カルニチン、乳酸菌、エラスチンなどを例示することができる。 Moreover, in the composition for external use of this invention, physiologically active components and pharmacologically active components other than ceramide can also be mix | blended with the external composition agent of this invention as needed in the range which does not impair the effect of this invention. Examples of such components include vitamins, amino acids and polymers thereof (peptides and proteins), polyphenols, plant extracts, royal jelly, proteins, carnitine, lactic acid bacteria, and elastin.
ここで、その他の成分としては、保湿剤（保湿性を有する成分）が好ましくは、例えば、高級アルコール、蝋、植物ステロール及びそのエステルなどを挙げることができる。これらの保湿剤は、１種単独でも、２種以上組み合わせて使用することもでき、その含有量は、外用組成物中４〜１２重量％が好ましい。 Here, the other components are preferably humectants (components having moisturizing properties), and examples thereof include higher alcohols, waxes, plant sterols and esters thereof. These humectants can be used alone or in combination of two or more, and the content thereof is preferably 4 to 12% by weight in the composition for external use.
高級アルコールとは、一般的に炭素数６以上のアルコールであって、炭素数は１４〜２２が好ましく、炭素数が１８〜２２がより好ましい。具体例としては、たとえばミリスチルアルコール、イソステアリルアルコール、セチルアルコール、ステアリルアルコール、オレイルアルコール、アラキルアルコール、２−オクチルドデカノール、コレステロール、フィトステロール、２−ヘキシルデカノール、ベヘニルアルコール、ラノリンアルコール、ラウリルアルコール等が挙げられる。これら高級アルコールは、１種単独でも、２種以上組み合わせて使用することもできる。 The higher alcohol is generally an alcohol having 6 or more carbon atoms, preferably 14 to 22 carbon atoms, and more preferably 18 to 22 carbon atoms. Specific examples include myristyl alcohol, isostearyl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol, aralkyl alcohol, 2-octyldodecanol, cholesterol, phytosterol, 2-hexyldecanol, behenyl alcohol, lanolin alcohol, lauryl alcohol and the like. It is done. These higher alcohols can be used alone or in combination of two or more.
蝋とは、高級脂肪酸と高級アルコールのエステルで融点の高い油脂状の物質であって、由来により植物系、動物系、鉱物系に分類される。具体例としては、カルナバロウ、パームロウ等の植物系蝋；ミツロウ、鯨蝋、羊毛蝋等の動物系蝋；マイクロクリスタリンワックス、パラフィンワックス、セレシンワックス等の鉱物系蝋等が挙げられる。これら蝋は、１種単独でも、２種以上組み合わせて使用することもできる。 Wax is an ester of higher fatty acid and higher alcohol and is an oily substance having a high melting point, and is classified into plant type, animal type and mineral type according to its origin. Specific examples include plant waxes such as carnauba wax and palm wax; animal waxes such as beeswax, whale wax and wool wax; mineral waxes such as microcrystalline wax, paraffin wax and ceresin wax. These waxes can be used alone or in combination of two or more.
植物ステロールとは、広く植物に含まれている成分であって、コレステロールと化学構造上の基本骨格が類似している成分であり、脂肪酸とエステルを形成することが知られる。具体例としては、フィトステロール、シトステロール、シタステロール、カンペシウテロール、マカデミアナッツ油脂肪酸フィトステアリル、オレイン酸フィトステリル等が挙げられる。これらの植物ステロール及びそのエステルは、１種単独でも、２種以上組み合わせて使用することもできる。 Plant sterol is a component widely contained in plants, and is a component having a basic structure similar to cholesterol in chemical structure, and is known to form an ester with a fatty acid. Specific examples include phytosterol, sitosterol, sitasterol, campecuterol, macadamia nut oil fatty acid phytostearyl, phytosteryl oleate, and the like. These plant sterols and esters thereof can be used singly or in combination of two or more.
本発明の外用組成物は、固形状である。固形とは、レオメーターで測定した硬度が５０〜２５０ｋｇであることであって、５０〜１００ｋｇであることが好ましい。固形状の外用組成物としては、スティック剤、チック剤、軟膏剤などが挙げられる。また、本発明の外用組成物は、保湿効果が高いため、抗しわ用剤、保湿剤、化粧下地、美容剤などの用途に適用することができる。 The external composition of the present invention is solid. Solid means that the hardness measured with a rheometer is 50 to 250 kg, and preferably 50 to 100 kg. Examples of solid external compositions include sticks, tics, ointments and the like. Moreover, since the external composition of the present invention has a high moisturizing effect, it can be applied to uses such as an anti-wrinkle agent, a moisturizing agent, a makeup base, and a cosmetic agent.
本発明の外用組成物は、前述の各成分を混合することによって作製するが、混合する際に、たとえば８０〜１５０℃に加熱してもよい。 The composition for external use of the present invention is prepared by mixing the above-described components, and may be heated to, for example, 80 to 150 ° C. when mixing.
実施例に基づいて、本発明を具体的に説明するが、本発明はこれらのみに限定されるものではない。 The present invention will be specifically described based on examples, but the present invention is not limited to these examples.
実施例１〜１０及び比較例１〜３
表１に示す含有量の各成分を約１００℃〜１２０℃に加温し攪拌、混合、冷却することにより外用組成物を作製した。なお、高級アルコールとしては、イソステアリルアルコールを使用し、表１の単位は「重量％」である。表１のセラミド２および３については、それぞれ以下の原料を使用した。
セラミド２：Ｎ−ステアロイルジヒドロスフィンゴシン（商品名：ＣＥＲＡＭＩＤＥ ＴＩＣ−００１（高砂香料工業株式会社製））
セラミド３：Ｎ−ステアロイルフィトスフィンゴシン（ＣＥＲＡＭＩＤＥ ＩＩＩ（エボニックジャパン株式会社製））
Examples 1 to 10 and Comparative Examples 1 to 3
Each component having the content shown in Table 1 was heated to about 100 ° C. to 120 ° C., stirred, mixed, and cooled to prepare an external composition. As the higher alcohol, isostearyl alcohol is used, and the unit in Table 1 is “% by weight”. For ceramides 2 and 3 in Table 1, the following raw materials were used.
Ceramide 2: N-stearoyl dihydrosphingosine (trade name: CERAMIDE TIC-001 (manufactured by Takasago International Corporation))
Ceramide 3: N-stearoyl phytosphingosine (CERAMIDE III (Evonik Japan Co., Ltd.))
得られた組成物の硬度を、レオメーターＣＲ−５００ＤＸ（株式会社サン科学製）を用いて測定し、以下の基準に従って評価した。評価結果を表１に示す。
××：０〜５０ｋｇ
○ ：５０〜１００ｋｇ
△ ：１００〜２５０ｋｇ
× ：２５０ｋｇ以上
The hardness of the obtained composition was measured using a rheometer CR-500DX (manufactured by Sun Kagaku Co., Ltd.) and evaluated according to the following criteria. The evaluation results are shown in Table 1.
XX: 0-50kg
○: 50-100 kg
Δ: 100-250 kg
×: 250 kg or more
比較例１〜３の外用組成物では、（Ｂ）グリセリン脂肪酸エステルまたは（Ｃ）脂肪油を含有しないため、硬度が２５０ｋｇを超え、硬すぎるため、なめらかさに欠け、皮膚に塗りこんだ際の使用感が使用者の満足に耐えるものではなかった。一方、（Ｂ）グリセリン脂肪酸エステルおよび（Ｃ）脂肪油を含有する実施例１および２の外用組成物では、硬度が１００〜２５０ｋｇとなり、やや固いものの、皮膚に塗りこんだ際の使用感が充分に使用者の満足に耐える組成物となった。また、（Ａ）セラミド類１重量部に対し、（Ｂ）グリセリン脂肪酸エステルを５重量部以上、（Ｂ）および（Ｃ）の合計量で６重量部以上含有する実施例３〜１０の外用組成物では、硬度が５０〜１００ｋｇとなり、より使用者の満足に足る組成物となった。 In the composition for external use of Comparative Examples 1 to 3, since it does not contain (B) glycerin fatty acid ester or (C) fatty oil, the hardness exceeds 250 kg and is too hard, so it lacks smoothness and is applied to the skin. The feeling of use did not withstand user satisfaction. On the other hand, the compositions for external use of Examples 1 and 2 containing (B) glycerin fatty acid ester and (C) fatty oil have a hardness of 100 to 250 kg and are somewhat hard, but have a satisfactory feeling when applied to the skin. In this way, the composition can withstand user satisfaction. Moreover, the external composition of Examples 3-10 which contains 5 weight part or more of (B) glycerine fatty acid ester with respect to 1 weight part of (A) ceramides, and 6 weight part or more in the total amount of (B) and (C). In the product, the hardness was 50 to 100 kg, and the composition was more satisfactory for the user.
処方例１〜２
表２に、本発明の外用組成物の処方例を示す。なお、表２の単位は「重量％」である。表２のセラミド１については以下の原料を、セラミド２、３については表１と同一の原料をそれぞれ使用した。
セラミド１：Ｎ−（２７−ステアロイルオキシヘプタコサノイル）フィトスフィンゴシン（商品名：ＣＥＲＡＭＩＤＥ Ｉ（エボニックジャパン株式会社製））
Formulation Examples 1-2
Table 2 shows formulation examples of the composition for external use of the present invention. The unit in Table 2 is “% by weight”. The following raw materials were used for ceramide 1 in Table 2, and the same raw materials as in Table 1 were used for ceramides 2 and 3, respectively.
Ceramide 1: N- (27-stearoyloxyheptacosanoyl) phytosphingosine (trade name: CERAMIDE I (Evonik Japan Co., Ltd.))
これらの処方例に示した外用組成物も、同様に適度な硬度を有しており、皮膚に塗りこんだ際の使用感が使用者の満足に耐える組成物となった。 Similarly, the compositions for external use shown in these formulation examples also have an appropriate hardness, and the feeling of use when applied to the skin is a composition that can satisfy the user's satisfaction.
本発明の外用組成物は、セラミド類を高濃度で含有するにもかかわらず、適度な硬度を有する固形状の組成物であるため、皮膚へ塗りやすく持続性に優れ、抗しわ用剤や保湿剤などの用途に適用することができる。
The composition for external use of the present invention is a solid composition having an appropriate hardness despite containing a high concentration of ceramides. It can be applied to uses such as agents.
Claims (4)
（Ａ）セラミド類１重量部に対し、（Ｂ）グリセリン脂肪酸エステルを２重量部以上、（Ｂ）グリセリン脂肪酸エステルおよび（Ｃ）脂肪油を合計で６重量部以上含有する固形状の外用組成物。 (A) ceramides 4 to 12% by weight, (B) glycerin fatty acid ester, and (C) fatty oil,
(A) Solid external composition containing 2 parts by weight or more of (B) glycerin fatty acid ester and 6 parts by weight or more in total of (B) glycerin fatty acid ester and (C) fatty oil per 1 part by weight of ceramides .
The solid external composition in any one of Claims 1-3 which does not contain water substantially.
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| CN108208194A (en) * | 2016-12-09 | 2018-06-29 | 嘉里特种油脂（上海）有限公司 | A kind of impervious fluid composition |
| JP2020203862A (en) * | 2019-06-18 | 2020-12-24 | 小林製薬株式会社 | External composition for improving skin barrier function |
| WO2020255866A1 (en) * | 2019-06-18 | 2020-12-24 | 小林製薬株式会社 | Topical composition |
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| JP2020203861A (en) * | 2019-06-18 | 2020-12-24 | 小林製薬株式会社 | External composition |
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