JP2015522012A - ロチゴチンを含有した経皮吸収製剤(Transdermalcompositioncomprisingrotigotine) - Google Patents
ロチゴチンを含有した経皮吸収製剤(Transdermalcompositioncomprisingrotigotine) Download PDFInfo
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- JP2015522012A JP2015522012A JP2015520068A JP2015520068A JP2015522012A JP 2015522012 A JP2015522012 A JP 2015522012A JP 2015520068 A JP2015520068 A JP 2015520068A JP 2015520068 A JP2015520068 A JP 2015520068A JP 2015522012 A JP2015522012 A JP 2015522012A
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
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- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Psychology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
Description
結晶防止剤を含有したパッチの製造及び結晶評価
下記表1により3種の結晶防止剤を添加したロチゴチン経皮剤を製造した。
結晶防止剤の比率別パッチ製造及び結晶評価
結晶防止剤の比率によるロチゴチンの結晶程度を測定した。
結晶防止剤の比率別パッチのIn vitroでの透過実験
Claims (10)
- ロチゴチンを脂肪アルコール、脂肪酸、脂肪酸エステル、脂肪酸アミド及びこれの誘導体からなる群より選ばれた一つ以上の結晶防止剤と混合する段階を含むロチゴチンの結晶防止方法。
- 前記ロチゴチンと結晶防止剤は10:0.1乃至40の重量比で混合されることを特徴とする請求項1記載の方法。
- 前記ロチゴチンと結晶防止剤は10:0.1乃至30の重量比で混合されることを特徴とする請求項2記載の方法。
- ロチゴチンと、脂肪アルコール、脂肪酸、脂肪酸エステル、脂肪酸アミド及びこれの誘導体からなる群より選ばれた一つ以上の結晶防止剤とを有効成分として含む経皮吸収製剤。
- ロチゴチンを脂肪アルコール、脂肪酸、脂肪酸エステル、脂肪酸アミド及びこれの誘導体からなる群より選ばれた一つ以上の物質と混合する段階を含む経皮吸収製剤の製造方法。
- 脂肪アルコール、脂肪酸、脂肪酸エステル、脂肪酸アミド及びこれの誘導体からなる群より選ばれた一つ以上の結晶防止剤、ロチゴチン及び粘着剤を含む薬剤含有粘着剤層、並びに前記薬剤含有粘着剤層を支持する基材を含む経皮治療システム。
- 前記粘着剤は、シリコーン系粘着剤、ゴム系粘着剤、アクリル系粘着剤及びエチレンービニルアセテート粘着剤からなる群より選ばれた粘着剤であることを特徴とする請求項6記載のシステム。
- 前記ゴム系粘着剤はスチレン系粘着剤であることを特徴とする請求項7記載のシステム。
- 前記結晶防止剤は、前記薬剤含有粘着剤層の総重量に対して、0.1%重量より多く、37重量%以下に含まれることを特徴とする請求項6記載のシステム。
- 前記薬剤含有粘着剤層は、ロチゴチン、結晶防止剤及び粘着剤を10:0.1乃至40:40乃至500の重量比で含むことを特徴とする請求項6記載のシステム。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2012-0073295 | 2012-07-05 | ||
KR20120073295 | 2012-07-05 | ||
PCT/KR2013/006001 WO2014007579A1 (ko) | 2012-07-05 | 2013-07-05 | 로티고틴을 함유한 경피흡수제제 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2015522012A true JP2015522012A (ja) | 2015-08-03 |
JP6180520B2 JP6180520B2 (ja) | 2017-08-16 |
Family
ID=49882267
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015520068A Active JP6180520B2 (ja) | 2012-07-05 | 2013-07-05 | ロチゴチンを含有した経皮吸収製剤(Transdermalcompositioncomprisingrotigotine) |
Country Status (9)
Country | Link |
---|---|
US (1) | US20150118282A1 (ja) |
EP (1) | EP2870962B1 (ja) |
JP (1) | JP6180520B2 (ja) |
KR (1) | KR101558042B1 (ja) |
AU (1) | AU2013285733B2 (ja) |
BR (1) | BR112015000107B1 (ja) |
CA (1) | CA2878376C (ja) |
MX (1) | MX2015000049A (ja) |
WO (1) | WO2014007579A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022050056A1 (ja) * | 2020-09-03 | 2022-03-10 | 株式会社カネカ | 貼付剤、及びその製造方法 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014193190A1 (ko) * | 2013-05-30 | 2014-12-04 | 에스케이케미칼 (주) | 로티고틴과 지방산 및 스티렌 점착제를 함유한 경피치료시스템 |
CN110638792B (zh) * | 2019-10-16 | 2022-04-19 | 沈阳药科大学 | 一种罗替戈汀经皮吸收贴剂及其制备和应用 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997037659A1 (en) * | 1996-04-08 | 1997-10-16 | Sano Corporation | Transdermal delivery device for azapirone compounds |
JP2005528413A (ja) * | 2002-05-06 | 2005-09-22 | シュバルツ ファルマ アクチェンゲゼルシャフト | レストレスレッグス症候群を処置するための経外角皮的投与形 |
JP2005535687A (ja) * | 2002-07-30 | 2005-11-24 | シュバルツ ファルマ アクチェンゲゼルシャフト | ロチゴチン投与のための改善された経皮送達系 |
WO2008044336A1 (fr) * | 2006-10-11 | 2008-04-17 | Hisamitsu Pharmaceutical Co., Inc. | Préparation adhésive contenant un cristal |
JP2008266198A (ja) * | 2007-04-19 | 2008-11-06 | Hisamitsu Pharmaceut Co Inc | 貼付剤 |
JP2009029768A (ja) * | 2007-07-24 | 2009-02-12 | Kosumedei Seiyaku Kk | 経皮吸収テープ製剤 |
WO2009139411A1 (ja) * | 2008-05-15 | 2009-11-19 | 久光製薬株式会社 | パロノセトロンを含有する経皮吸収製剤 |
JP2010532390A (ja) * | 2007-07-06 | 2010-10-07 | 北京康倍得医薬技術開發有限公司 | ロチゴチン含有組成物及びその使用並びにこの組成物を含む経皮貼付剤 |
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DE19814084B4 (de) | 1998-03-30 | 2005-12-22 | Lts Lohmann Therapie-Systeme Ag | D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung |
DE60100595T2 (de) * | 2001-05-08 | 2004-06-24 | Lts Lohmann Therapie-Systeme Ag | Verbessertes transdermales therapeutisches System zur Behandlung von Morbus Parkinson |
US20040005339A1 (en) * | 2002-06-28 | 2004-01-08 | Shojaei Amir H. | Formulations of fenofibrate and/or fenofibrate derivatives with improved oral bioavailability |
US8246979B2 (en) * | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system for the administration of rotigotine |
DE10234673B4 (de) * | 2002-07-30 | 2007-08-16 | Schwarz Pharma Ag | Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren |
WO2008009512A1 (en) * | 2006-07-18 | 2008-01-24 | Symrise Gmbh & Co. Kg | Cyclodextrin blends with crystal growth inhibitors |
US20090202647A1 (en) * | 2008-02-11 | 2009-08-13 | Mayur Devjibhai Khunt | Solid form of racemic rotigotine |
EP3257504B1 (en) | 2009-12-22 | 2024-06-19 | UCB Biopharma SRL | Polyvinylpyrrolidone for the stabilization of a solid dispersion of the non-crystalline form of rotigotine |
EP2642993B1 (en) * | 2010-11-25 | 2016-03-02 | Shan Dong Luye Pharmaceutical Co., Ltd. | Compositions of rotigotine or pharmaceutically acceptable salts of rotigotine |
EP2457565A1 (de) * | 2010-11-29 | 2012-05-30 | Ratiopharm GmbH | Transdermales therapeutisches System enthaltend Rotigotin |
-
2013
- 2013-07-05 JP JP2015520068A patent/JP6180520B2/ja active Active
- 2013-07-05 CA CA2878376A patent/CA2878376C/en active Active
- 2013-07-05 MX MX2015000049A patent/MX2015000049A/es unknown
- 2013-07-05 KR KR1020130079198A patent/KR101558042B1/ko active IP Right Grant
- 2013-07-05 EP EP13812795.6A patent/EP2870962B1/en not_active Not-in-force
- 2013-07-05 BR BR112015000107-6A patent/BR112015000107B1/pt active IP Right Grant
- 2013-07-05 AU AU2013285733A patent/AU2013285733B2/en active Active
- 2013-07-05 WO PCT/KR2013/006001 patent/WO2014007579A1/ko active Application Filing
-
2015
- 2015-01-05 US US14/589,851 patent/US20150118282A1/en not_active Abandoned
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997037659A1 (en) * | 1996-04-08 | 1997-10-16 | Sano Corporation | Transdermal delivery device for azapirone compounds |
JP2005528413A (ja) * | 2002-05-06 | 2005-09-22 | シュバルツ ファルマ アクチェンゲゼルシャフト | レストレスレッグス症候群を処置するための経外角皮的投与形 |
JP2005535687A (ja) * | 2002-07-30 | 2005-11-24 | シュバルツ ファルマ アクチェンゲゼルシャフト | ロチゴチン投与のための改善された経皮送達系 |
WO2008044336A1 (fr) * | 2006-10-11 | 2008-04-17 | Hisamitsu Pharmaceutical Co., Inc. | Préparation adhésive contenant un cristal |
JP2008266198A (ja) * | 2007-04-19 | 2008-11-06 | Hisamitsu Pharmaceut Co Inc | 貼付剤 |
JP2010532390A (ja) * | 2007-07-06 | 2010-10-07 | 北京康倍得医薬技術開發有限公司 | ロチゴチン含有組成物及びその使用並びにこの組成物を含む経皮貼付剤 |
JP2009029768A (ja) * | 2007-07-24 | 2009-02-12 | Kosumedei Seiyaku Kk | 経皮吸収テープ製剤 |
WO2009139411A1 (ja) * | 2008-05-15 | 2009-11-19 | 久光製薬株式会社 | パロノセトロンを含有する経皮吸収製剤 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022050056A1 (ja) * | 2020-09-03 | 2022-03-10 | 株式会社カネカ | 貼付剤、及びその製造方法 |
Also Published As
Publication number | Publication date |
---|---|
CA2878376A1 (en) | 2014-01-09 |
MX2015000049A (es) | 2015-04-08 |
WO2014007579A1 (ko) | 2014-01-09 |
KR101558042B1 (ko) | 2015-10-07 |
BR112015000107B1 (pt) | 2022-07-19 |
EP2870962B1 (en) | 2018-09-12 |
JP6180520B2 (ja) | 2017-08-16 |
EP2870962A4 (en) | 2016-03-02 |
US20150118282A1 (en) | 2015-04-30 |
AU2013285733A1 (en) | 2015-02-05 |
AU2013285733B2 (en) | 2016-11-10 |
EP2870962A1 (en) | 2015-05-13 |
CA2878376C (en) | 2018-08-07 |
BR112015000107A2 (pt) | 2019-10-08 |
KR20140006727A (ko) | 2014-01-16 |
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