JP2015129750A - 糖尿病管理モニタで分析物濃度を動的に較正および測定するためのシステムおよび方法 - Google Patents
糖尿病管理モニタで分析物濃度を動的に較正および測定するためのシステムおよび方法 Download PDFInfo
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Abstract
Description
1.グルコースがセンサに入る、
2.グルコースがセンサによって拡散する、
3.拡散平衡が達成される、
4.グルコース分子がグルコース結合タンパク質分子(GBP)と結合する、
5.結合が蛍光スペクトルを修正する、
6.結合平衡が達成される、
7.光がGBPを刺激する、
8.GBPが蛍光を発する、および、
9.蛍光信号がセンサから出て検出される。
1.蛍光信号を検出する、
2.信号を規格化する、
3.光のスペクトルシグネチャを決定する、
4.シグネチャを創出する放出状態の濃度分率を決定する、および、
5.濃度分率状態を誘導するグルコースの濃度を決定する。
コンフィギュレーションスペクトル
σopen(λ)=σopen(λ,[G]=0)
光学フィルタ
飽和分率
Y∈[0,1]=グルコースによって飽和させられたGBP分子の分率
nopen+nclosed=N
であり、nは、それらのそれぞれのコンフィギュレーションでのGBPの数であり、Nは、任意のコンフィギュレーションでの活動状態のGBPの数である。
σi(λ)、i∈{1…C}
を有する。
{λcrossing|σi(λcrossing)=σj(λcrossing)} ∀i,j∈{1…C}
がある場合、次式のようになる。
ただしχは、交差点の周囲の帯域での[G]=0での測定される強度であり、εは許容誤差項である。
=Y∫σclosed(λ)λ-2dλ+(1−Y)∫σopen(λ)λ-2dλ
=Y[∫σclosed(λ)λ-2dλ−∫σopen(λ)λ-2dλ+(1−Y)]+∫σopen(λ)λ-2dλ
=Y[∫(σclosed(λ)−σopen(λ))λ-2dλ]+∫σopen(λ)λ-2dλ
σref(λ)=Href(λ)・σtotal(λ)λ-2dλ
Iref=∫ΛHref(λ)・σtotal(λ)λ-2dλ
現実世界のフィルタは単一の周波数を分離することが可能でないので、擬似的な不変参照帯域を見出すことが好ましい。これは、次式のように表され得る。
ただしεは、参照チャネル上の許容変動により決定される。
全体的な検出されるパワーを最大化し、SNRを増大することになる信号チャネルとして使用するための通過帯域を見出すことが好ましい。信号チャネルはさらに、好ましくは、グルコースの任意の変化に最大限に高感度である。上記で論考されたように、すべてのスペクトルが基礎スペクトルの線形組み合わせであるので、および、積分(パワー)が加法的であるので、2つの基礎状態の間で最大限に変化している最も大きな範囲を見出せばよい。
Claims (30)
- 分析物の濃度を決定するための光学分析物センサであって、
未知の濃度での前記分析物を内包する試料を受けるためのマトリクスと、
前記試料上で、刺激周波数で光を放出するための光放出体と、
第1の等吸収周波数で、および第2の周波数で蛍光信号を受けるための、ならびに、前記第1および前記第2の周波数で前記蛍光信号の強度を測定するための光受信器と、
前記第1および前記第2の周波数で測定される前記それぞれの強度に基づいて前記分析物の濃度を決定するためのプロセッサと
を備えることを特徴とする光学分析物センサ。 - 前記センサはインビトロセンサであることを特徴とする請求項1に記載の光学分析物センサ。
- 前記センサはインビボセンサであることを特徴とする請求項1に記載の光学分析物センサ。
- 前記センサは連続センサであることを特徴とする請求項1に記載の光学分析物センサ。
- 前記分析物はグルコースであることを特徴とする請求項1に記載の光学分析物センサ。
- 前記分析物はヘモグロビンHbA1cであることを特徴とする請求項1に記載の光学分析物センサ。
- 前記分析物は糖化アルブミンであることを特徴とする請求項1に記載の光学分析物センサ。
- 前記マトリクスは、グルコースの存在下の第1のコンホメーション、および、グルコースの非存在下の第2のコンホメーションをとるグルコース結合タンパク質を備えることを特徴とする請求項1に記載の光学分析物センサ。
- 前記マトリクスはボロン酸を備えることを特徴とする請求項1に記載の光学分析物センサ。
- 前記マトリクスは任意の分析物結合化合物を備えることを特徴とする請求項1に記載の光学分析物センサ。
- 前記マトリクスは任意のグルコース結合化合物を備えることを特徴とする請求項1に記載の光学分析物センサ。
- 光学分析物センサとインスリン注入デバイスとを備える糖尿病管理システムであって、
前記光学分析物センサは、
未知の濃度での分析物を内包する試料を受けるためのマトリクスと、
前記試料上で、刺激周波数で光を放出するための光放出体と、
第1の等吸収周波数で、および第2の周波数で蛍光信号を受けるための、ならびに、前記第1および前記第2の周波数で前記蛍光信号の強度を測定するための光受信器と、
前記第1および前記第2の周波数で測定される前記それぞれの強度に基づいて前記分析物の濃度を決定するためのプロセッサと
を備え、
前記分析物センサは、前記インスリン注入デバイスに信号を送信するための送受信器をさらに備えることを特徴とする糖尿病管理システム。 - 前記プロセッサはインスリン要件をさらに決定し、前記インスリン注入デバイスに送信される前記信号は、前記決定されたインスリン要件に基づくインスリン要件を備えることを特徴とする請求項12に記載の糖尿病管理システム。
- 前記センサはインビトロセンサであることを特徴とする請求項12に記載の糖尿病管理システム。
- 前記センサはインビボセンサであることを特徴とする請求項12に記載の糖尿病管理システム。
- 前記センサは連続センサであることを特徴とする請求項12に記載の糖尿病管理システム。
- 前記分析物はグルコースであることを特徴とする請求項12に記載の糖尿病管理システム。
- 前記分析物はヘモグロビンHbA1cであることを特徴とする請求項12に記載の糖尿病管理システム。
- 前記分析物は糖化アルブミンであることを特徴とする請求項12に記載の糖尿病管理システム。
- 未知の濃度での分析物を内包する試料を受けるためのマトリクスと、
前記試料上で、刺激周波数で光を放出するための光放出体と、
第1の等吸収周波数で、および第2の周波数で蛍光信号を受けるための、ならびに、前記第1および前記第2の周波数で前記蛍光信号の強度を測定するための光受信器と、
前記第1および前記第2の周波数で測定される前記それぞれの強度に基づいて前記分析物の濃度を決定するためのプロセッサと
を備え、
前記プロセッサは、事前の強度測定に基づいてセンサドリフトをさらに決定し、前記決定されたセンサドリフトに基づいて、前記決定された濃度を補正することを特徴とする光学分析物センサ。 - 遠隔デバイスに決定された分析物濃度を指示する信号を送信するための送受信器をさらに備えることを特徴とする請求項20に記載の光学分析物センサ。
- 前記遠隔デバイスはスマートフォンであることを特徴とする請求項21に記載の光学分析物センサ。
- 前記送受信器は遠隔記憶デバイスに信号を送信することを特徴とする請求項21に記載の光学分析物センサ。
- 前記光学センサは、エネルギー源を備え、少なくとも1日の連続使用に適合させられることを特徴とする請求項20に記載の光学分析物センサ。
- 前記光学センサは受容者の皮下の空間で使用されることを特徴とする請求項20に記載の光学分析物センサ。
- 前記光学センサは受容者の皮内の空間で使用されることを特徴とする請求項20に記載の光学分析物センサ。
- 前記光学センサは受容者の皮上の空間で使用されることを特徴とする請求項20に記載の光学分析物センサ。
- 前記光学センサは受容者の脈管内の空間で使用されることを特徴とする請求項20に記載の光学分析物センサ。
- 前記光学センサは体液で使用されることを特徴とする請求項20に記載の光学分析物センサ。
- 前記光学分析物センサはインビトロセンサであることを特徴とする請求項20に記載の光学分析物センサ。
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020096185A1 (ko) * | 2018-11-08 | 2020-05-14 | 주식회사 와이트랙 | 형광 센서 기반의 혈당 모니터링 장치 및 그 방법 |
JP2021529943A (ja) * | 2018-06-28 | 2021-11-04 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | 血液培養測定システムにおける信号を正規化するためのシステム及び方法 |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8741591B2 (en) | 2009-10-09 | 2014-06-03 | The Research Foundation For The State University Of New York | pH-insensitive glucose indicator protein |
AU2017298463B2 (en) * | 2016-07-20 | 2022-09-01 | University Of Maryland, Baltimore | Silicone hydrogel based fluorescent assay and contact lens |
US10978280B2 (en) * | 2017-12-29 | 2021-04-13 | Elemental Scientific, Inc. | Systems and methods for ICPMS matrix offset calibration |
DE102018133701A1 (de) | 2017-12-29 | 2019-07-04 | Elemental Scientific, Inc. | Systeme und Verfahren zur ICPMS-Matrix-Offset-Kalibrierung |
US10900892B1 (en) | 2020-02-17 | 2021-01-26 | SciLogica Corp. | Validation of sensor calibration |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5094958A (en) * | 1990-08-30 | 1992-03-10 | Fiberchem Inc. | Method of self-compensating a fiber optic chemical sensor |
JPH0682459A (ja) * | 1991-11-20 | 1994-03-22 | Hamamatsu Photonics Kk | 蛍光性プローブ試薬を用いた細胞内イオン濃度測定法 |
JPH11508792A (ja) * | 1995-07-06 | 1999-08-03 | トーマス ジエフアーソン ユニバーシテイ | 血液成分レベル測定制御用埋込可能センサ及びシステム |
JP2000019172A (ja) * | 1998-07-03 | 2000-01-21 | Matsushita Electric Ind Co Ltd | 多波長蛍光偏光法 |
US20040087842A1 (en) * | 2002-05-30 | 2004-05-06 | Lakowicz Joseph R. | Fluorescent probes for saccharrides |
US20090018418A1 (en) * | 2007-05-10 | 2009-01-15 | Glumetrics, Inc. | Equilibrium non-consuming fluorescence sensor for real time intravascular glucose measurement |
JP2013514809A (ja) * | 2009-12-22 | 2013-05-02 | スリーエム イノベイティブ プロパティズ カンパニー | 微生物を検出する方法及びそのためのキット |
Family Cites Families (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02390A (ja) | 1987-11-04 | 1990-01-05 | Sumitomo Electric Ind Ltd | 超電導体層を有する半導体基板 |
US5593852A (en) | 1993-12-02 | 1997-01-14 | Heller; Adam | Subcutaneous glucose electrode |
WO1992019957A2 (en) | 1991-05-03 | 1992-11-12 | University Of Maryland At Baltimore | Method for optically measuring chemical analytes |
US5409835A (en) | 1992-12-30 | 1995-04-25 | The University Of Maryland At Baltimore | Long-wavelength fluorescent probe compounds for calcium ions and their use in ratiometrically measuring calcium ion concentrations |
US5605152A (en) | 1994-07-18 | 1997-02-25 | Minimed Inc. | Optical glucose sensor |
US5628310A (en) | 1995-05-19 | 1997-05-13 | Joseph R. Lakowicz | Method and apparatus to perform trans-cutaneous analyte monitoring |
US6766183B2 (en) | 1995-11-22 | 2004-07-20 | Medtronic Minimed, Inc. | Long wave fluorophore sensor compounds and other fluorescent sensor compounds in polymers |
ATE227844T1 (de) | 1997-02-06 | 2002-11-15 | Therasense Inc | Kleinvolumiger sensor zur in-vitro bestimmung |
US6862465B2 (en) * | 1997-03-04 | 2005-03-01 | Dexcom, Inc. | Device and method for determining analyte levels |
CA2294610A1 (en) | 1997-06-16 | 1998-12-23 | George Moshe Katz | Methods of calibrating and testing a sensor for in vivo measurement of an analyte and devices for use in such methods |
US6168957B1 (en) | 1997-06-25 | 2001-01-02 | Lifescan, Inc. | Diagnostic test strip having on-strip calibration |
US6579690B1 (en) | 1997-12-05 | 2003-06-17 | Therasense, Inc. | Blood analyte monitoring through subcutaneous measurement |
CA2316199C (en) | 1997-12-31 | 2012-03-27 | Duke University | Biosensor |
US6175752B1 (en) | 1998-04-30 | 2001-01-16 | Therasense, Inc. | Analyte monitoring device and methods of use |
PT1077636E (pt) | 1998-05-13 | 2004-06-30 | Cygnus Therapeutic Systems | Processamento de sinal para medicao de analitos fisiologicos |
ATE246356T1 (de) | 1998-05-13 | 2003-08-15 | Cygnus Therapeutic Systems | Vorrichtung zum vorhersagen von physiologischen messwerten |
TW406018B (en) | 1998-05-21 | 2000-09-21 | Elan Corp Plc | Improved adhesive system for medical devices |
GB9814506D0 (en) | 1998-07-03 | 1998-09-02 | Stanley Christopher J | Optical sensor for insitu measurement of analytes |
CN102226766B (zh) * | 1998-08-26 | 2017-03-01 | 医药及科学传感器公司 | 基于光学的感测装置 |
DE69908602T2 (de) | 1998-09-30 | 2004-06-03 | Cygnus, Inc., Redwood City | Verfahren und vorrichtung zum vorhersagen von physiologischen messwerten |
US6157041A (en) | 1998-10-13 | 2000-12-05 | Rio Grande Medical Technologies, Inc. | Methods and apparatus for tailoring spectroscopic calibration models |
US6424847B1 (en) | 1999-02-25 | 2002-07-23 | Medtronic Minimed, Inc. | Glucose monitor calibration methods |
US6360888B1 (en) | 1999-02-25 | 2002-03-26 | Minimed Inc. | Glucose sensor package system |
AU779602B2 (en) | 2000-02-02 | 2005-02-03 | Ge Healthcare Uk Limited | Detection reagent |
US6615151B1 (en) | 2000-08-28 | 2003-09-02 | Cme Telemetrix Inc. | Method for creating spectral instrument variation tolerance in calibration algorithms |
US6560471B1 (en) | 2001-01-02 | 2003-05-06 | Therasense, Inc. | Analyte monitoring device and methods of use |
US6694158B2 (en) * | 2001-04-11 | 2004-02-17 | Motorola, Inc. | System using a portable detection device for detection of an analyte through body tissue |
US20030153026A1 (en) | 2002-01-04 | 2003-08-14 | Javier Alarcon | Entrapped binding protein as biosensors |
US7064103B2 (en) | 2002-01-04 | 2006-06-20 | Becton, Dickinson And Company | Binding protein as biosensors |
US6855556B2 (en) | 2002-01-04 | 2005-02-15 | Becton, Dickinson And Company | Binding protein as biosensors |
US7851593B2 (en) | 2002-01-04 | 2010-12-14 | Becton, Dickinson And Company | Binding proteins as biosensors |
US6780645B2 (en) | 2002-08-21 | 2004-08-24 | Lifescan, Inc. | Diagnostic kit with a memory storing test strip calibration codes and related methods |
US20050118726A1 (en) | 2002-08-26 | 2005-06-02 | Schultz Jerome S. | System and method for detecting bioanalytes and method for producing a bioanalyte sensor |
ATE423318T1 (de) | 2002-10-16 | 2009-03-15 | Univ Duke | Biosensor zum nachweis von glukose |
WO2004044557A2 (en) | 2002-11-12 | 2004-05-27 | Argose, Inc. | Non-invasive measurement of analytes |
US7236812B1 (en) * | 2003-09-02 | 2007-06-26 | Biotex, Inc. | System, device and method for determining the concentration of an analyte |
US7787923B2 (en) | 2003-11-26 | 2010-08-31 | Becton, Dickinson And Company | Fiber optic device for sensing analytes and method of making same |
US7496392B2 (en) | 2003-11-26 | 2009-02-24 | Becton, Dickinson And Company | Fiber optic device for sensing analytes |
US8774886B2 (en) | 2006-10-04 | 2014-07-08 | Dexcom, Inc. | Analyte sensor |
EP2256493B1 (en) * | 2003-12-05 | 2014-02-26 | DexCom, Inc. | Calibration techniques for a continuous analyte sensor |
WO2006014628A1 (en) | 2004-07-19 | 2006-02-09 | University Of Washington | Methods for assessing the risk for development of cardiovascular disease |
US7704704B2 (en) * | 2005-09-28 | 2010-04-27 | The Texas A&M University System | Implantable system for glucose monitoring using fluorescence quenching |
US20080275318A1 (en) | 2007-04-20 | 2008-11-06 | Becton, Dickinson And Company | Biosensors for measuring analytes in the interstitial fluid |
US20080269714A1 (en) | 2007-04-25 | 2008-10-30 | Medtronic Minimed, Inc. | Closed loop/semi-closed loop therapy modification system |
EP2150586B1 (en) | 2007-05-22 | 2018-03-14 | Becton, Dickinson and Company | Dyes having ratiometric fluorescence response for detecting metabolites |
WO2009021039A1 (en) | 2007-08-06 | 2009-02-12 | University Of Kentucky Research Foundation | Device for detection of molecules of interest |
US20090085768A1 (en) | 2007-10-02 | 2009-04-02 | Medtronic Minimed, Inc. | Glucose sensor transceiver |
US9023661B2 (en) | 2007-10-18 | 2015-05-05 | Becton, Dickinson And Company | Visual glucose sensor and methods of use thereof |
US8470300B2 (en) | 2008-09-08 | 2013-06-25 | The Charles Stark Draper Laboratory, Inc. | Coated sensors and methods related thereto |
US8741591B2 (en) | 2009-10-09 | 2014-06-03 | The Research Foundation For The State University Of New York | pH-insensitive glucose indicator protein |
US8467843B2 (en) | 2009-11-04 | 2013-06-18 | Glumetrics, Inc. | Optical sensor configuration for ratiometric correction of blood glucose measurement |
GB0920013D0 (en) | 2009-11-13 | 2009-12-30 | King S College London | Glucose sensor |
US9354226B2 (en) * | 2009-12-17 | 2016-05-31 | Ascensia Diabetes Care Holdings Ag | Transdermal systems, devices, and methods to optically analyze an analyte |
US20120252046A1 (en) * | 2009-12-17 | 2012-10-04 | Bayer Healthcare Llc | Transdermal systems, devices, and methods for biological analysis |
US8916136B2 (en) | 2010-04-23 | 2014-12-23 | Indian Institute Of Technology Bombay | Glucose biosensor system coupled with an anti-inflammatory module and methods for using the same |
US20120165636A1 (en) * | 2010-07-22 | 2012-06-28 | Feldman Benjamin J | Systems and Methods for Improved In Vivo Analyte Sensor Function |
WO2012122413A1 (en) * | 2011-03-08 | 2012-09-13 | University Of Maryland Baltimore County | Microscale bioprocessing system and method for protein manufacturing |
US20130060106A1 (en) * | 2011-09-06 | 2013-03-07 | Medtronic Minimed, Inc. | Optical sensing systems and methods |
DE102012201892A1 (de) * | 2012-02-09 | 2013-08-14 | Robert Bosch Gmbh | Bestimmung des Blutzuckerspiegels eines Patienten unter Verwendung eines implantierbaren Sensors und eines elektrischen Funktionspflasters |
-
2014
- 2014-07-31 US US14/448,867 patent/US10379125B2/en active Active
- 2014-12-15 CA CA2874679A patent/CA2874679C/en active Active
- 2014-12-17 JP JP2014255139A patent/JP6828988B2/ja active Active
- 2014-12-19 EP EP14199460.8A patent/EP2888999A1/en active Pending
- 2014-12-26 CN CN201420844498.5U patent/CN204542139U/zh active Active
-
2019
- 2019-06-27 US US16/455,307 patent/US11609234B2/en active Active
-
2020
- 2020-05-07 JP JP2020082061A patent/JP2020128998A/ja active Pending
-
2023
- 2023-01-20 JP JP2023007347A patent/JP2023052551A/ja active Pending
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5094958A (en) * | 1990-08-30 | 1992-03-10 | Fiberchem Inc. | Method of self-compensating a fiber optic chemical sensor |
JPH06500390A (ja) * | 1990-08-30 | 1994-01-13 | ファイバーケム、インコーポレイテッド | 自己補償型光ファイバ化学センサおよびその他の化学センサ |
JPH0682459A (ja) * | 1991-11-20 | 1994-03-22 | Hamamatsu Photonics Kk | 蛍光性プローブ試薬を用いた細胞内イオン濃度測定法 |
US5319209A (en) * | 1991-11-20 | 1994-06-07 | Hammamatsu Photonics K.K. | Method for measurement of intracellular ion concentration using fluorescence probe dyes |
JPH11508792A (ja) * | 1995-07-06 | 1999-08-03 | トーマス ジエフアーソン ユニバーシテイ | 血液成分レベル測定制御用埋込可能センサ及びシステム |
JP2000019172A (ja) * | 1998-07-03 | 2000-01-21 | Matsushita Electric Ind Co Ltd | 多波長蛍光偏光法 |
US20040087842A1 (en) * | 2002-05-30 | 2004-05-06 | Lakowicz Joseph R. | Fluorescent probes for saccharrides |
US20090018418A1 (en) * | 2007-05-10 | 2009-01-15 | Glumetrics, Inc. | Equilibrium non-consuming fluorescence sensor for real time intravascular glucose measurement |
JP2010526599A (ja) * | 2007-05-10 | 2010-08-05 | グルメトリクス、 インク. | 即時血管内グルコース測定のための平衡非消費蛍光センサー |
JP2013514809A (ja) * | 2009-12-22 | 2013-05-02 | スリーエム イノベイティブ プロパティズ カンパニー | 微生物を検出する方法及びそのためのキット |
Non-Patent Citations (1)
Title |
---|
KRISTIN WEIDEMAIER: "Multi-day pre-clinical demonstration of glucose/galactose binding protein-based fiber optic sensor", BIOSENSORS AND BIOELECTRONICS, vol. Vol.26/Iss.10, JPN6018041299, 15 June 2011 (2011-06-15), pages 4117 - 4123, ISSN: 0004255979 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2021529943A (ja) * | 2018-06-28 | 2021-11-04 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | 血液培養測定システムにおける信号を正規化するためのシステム及び方法 |
JP7492462B2 (ja) | 2018-06-28 | 2024-05-29 | ベクトン・ディキンソン・アンド・カンパニー | 血液培養測定システムにおける信号を正規化するためのシステム及び方法 |
WO2020096185A1 (ko) * | 2018-11-08 | 2020-05-14 | 주식회사 와이트랙 | 형광 센서 기반의 혈당 모니터링 장치 및 그 방법 |
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US11609234B2 (en) | 2023-03-21 |
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