JP2015038128A - One agent-type external skin preparation - Google Patents
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Abstract
Description
本発明は、少なくとも、固体状の酸性物質、前記酸性物質と反応して炭酸ガスを発生する固体状の炭酸ガス発生物質、及び、増粘剤とを含有し、水分を含む液体と混合して使用する一剤型皮膚外用剤に関する。 The present invention includes at least a solid acidic substance, a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide, and a thickener, and is mixed with a liquid containing moisture. The present invention relates to a one-part skin external preparation to be used.
従来より、皮膚に対し血行促進作用を有する合成又は天然エキス等が配合された皮膚外用剤が使用されてきた。 Conventionally, an external preparation for skin containing a synthetic or natural extract having a blood circulation promoting action on the skin has been used.
これらのエキスは少量の配合では効果が不十分であり、大量の配合では皮膚への刺激が大きすぎる等の理由から、炭酸ガスを含有させて血行促進作用の増進をはかった皮膚外用剤の提案がなされている。これらの多くは、酸性物質と炭酸ガス発生物質の反応により、炭酸ガスを発生させるものであるため、皮膚外用剤の炭酸発生能を長期間保持する観点から二剤のうちの少なくとも一剤を粘性物質とし、使用時にこれらを混合して発泡させる方法が取られていた。上記二剤の形態としては、例えば、水溶液と固体（特許文献１）、いずれもが粘性物質（特許文献２）、固体と粘性物質（特許文献３）を用いること等が提案されている。 These extracts are not effective in a small amount of formulation, and if a large amount of formulation is too irritating to the skin, a topical skin preparation that enhances blood circulation by containing carbon dioxide is proposed. Has been made. Many of these substances generate carbon dioxide by the reaction between an acidic substance and a carbon dioxide generating substance. Therefore, at least one of the two preparations is viscous from the viewpoint of maintaining the carbon dioxide generating ability of the external preparation for a long period of time. A method of mixing and foaming these at the time of use was used. As the form of the two agents, for example, it has been proposed to use an aqueous solution and a solid (Patent Document 1), both of which are viscous substances (Patent Document 2), and a solid and a viscous substance (Patent Document 3).
二剤型皮膚外用剤は製造のしやすさや保存性の点で優れているが、包装コスト等の製造コストが余計にかかるためコストダウンの観点と、取扱いの簡便性の観点から、全ての成分を一剤に含有する一剤型皮膚外用剤が望まれていた。 The two-part skin external preparation is excellent in terms of ease of manufacture and preservability, but all components are required from the viewpoint of cost reduction and easy handling because the manufacturing cost such as packaging cost is excessive. One-pack type external preparation for skin containing 1 in an agent has been desired.
ところで、酸性物質と炭酸塩等の炭酸ガス発生物質は水存在下で接触により炭酸ガスを発生するため、二剤型皮膚外用剤では、酸性物質と炭酸塩等を別々の剤に配合することにより、水分をいずれか一方の剤又は二剤共に含有させることができる。これに対し、一剤型皮膚外用剤は、保存安定性を高める観点から剤中に水分を含ませることができないため、固体状の製品として提供される。このため、使用に際して容器内等で前記一剤型皮膚外用剤と水分を含む液体とを混合することにより炭酸ガスの発泡を生じさせる必要がある。 By the way, since acidic substances and carbon dioxide generating substances such as carbonates generate carbon dioxide upon contact in the presence of water, in two-part skin external preparations, acidic substances and carbonates are blended into separate agents. , Water can be contained in either one agent or two agents. On the other hand, the one-pack type external preparation for skin is provided as a solid product because it cannot contain moisture from the viewpoint of enhancing the storage stability. For this reason, it is necessary to cause foaming of carbon dioxide gas by mixing the one-part skin external preparation and a liquid containing moisture in a container or the like when used.
また、炭酸ガスを発生させる皮膚外用剤としては、剤に粘性を持たせることにより炭酸ガスを剤中に保持させるタイプがよく知られているところ、二剤型皮膚外用剤の場合は、そのうちの一剤において増粘剤が水中で予め増粘した状態に調製することができるが、一剤型皮膚外用剤の場合は、上記のとおり剤中に水分を含ませることができないため、増粘剤が水中で予め増粘した状態に調製することができない。そして、増粘剤の溶解に際しては、一定の条件下で行う必要のあるものも多いため、外用剤の供給者が予め一定条件下で水分及び増粘剤を調製した二剤型皮膚外用剤が採用されていた。一方、一剤型皮膚外用剤では、利用者が使用時に水分を混合するため、様々な条件下でも瞬時に水に溶けて、炭酸ガスを保持して炭酸ガスによる十分な効果を得たり垂れ落ちを防止したりするために必要とされる粘性を水分を含む液体の混合直後に生じる皮膚外用剤の実現が求められていた。 In addition, as a skin external preparation that generates carbon dioxide gas, a type that retains carbon dioxide gas in the preparation by giving the agent a viscosity is well known. In one agent, the thickener can be prepared in a pre-thickened state in water. However, in the case of a one-part skin external preparation, the agent cannot contain moisture as described above. Cannot be prepared in a pre-thickened state in water. And since there are many things that need to be performed under certain conditions when dissolving the thickener, there are two-part skin external preparations in which the supplier of external preparations prepared moisture and thickener under certain conditions in advance. It was adopted. On the other hand, in the case of a one-part skin external preparation, the user mixes moisture during use, so it dissolves instantly in water under various conditions and retains carbon dioxide to obtain a sufficient effect of carbon dioxide or dripping. Therefore, there has been a demand for the realization of an external preparation for skin in which the viscosity required for preventing water is generated immediately after mixing of a liquid containing moisture.
更に、二剤型皮膚外用剤にて用いられる量の増粘剤をそのまま配合し、一剤型皮膚外用剤を作製したところ、混合時に皮膚外用剤が水分を含む液体に溶けにくくダマを生じやすい他、皮膚への塗布時にざらつき感を生じたり、十分な粘度が得られずに垂れ落ちたり、密着感が失われ血行促進作用が損なわれる等の問題が生じることが判明した。 Furthermore, the amount of thickening agent used in the two-part skin external preparation is blended as it is to produce a one-part skin external preparation. When mixed, the skin external preparation is difficult to dissolve in water-containing liquids and is likely to cause lumps. In addition, it has been found that problems such as a feeling of roughness when applied to the skin, sagging without obtaining sufficient viscosity, loss of adhesion, and impaired blood circulation promoting effects are caused.
本発明は、上記事情に鑑みなされたもので、低コストで、使用者が取り扱いやすく、利用者が様々な条件下で一剤型皮膚外用剤を水分を含む液体混合しても瞬時に溶解して、炭酸ガスの保持量が高く、ざらつき感や垂れ落ちが無く良好な使用感を有し、且つ優れた血行促進作用を有す一剤型皮膚外用剤の提供を目的とする。 The present invention has been made in view of the above circumstances, is low in cost, easy to handle by a user, and even if a user mixes a liquid preparation containing a one-component skin external preparation under various conditions, it instantly dissolves. Thus, an object of the present invention is to provide a one-part skin external preparation that has a high carbon dioxide retention amount, has a good feeling of use without rough feeling or sagging, and has an excellent blood circulation promoting action.
本発明者らは、固体状の酸性物質、前記酸性物質と反応して炭酸ガスを発生する固体状の炭酸ガス発生物質及び増粘剤を含有する一剤型皮膚外用剤において、前記増粘剤が親水性タンパク質化合物及びその他の増粘剤を併用することによって、取り扱いが容易且つ使用感も良好になることを見出し、本発明を完成するに至った。 In the one-part skin external preparation containing a solid acidic substance, a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide, and a thickener, the thickener However, by using a hydrophilic protein compound and other thickeners together, it was found that the handling was easy and the feeling of use was good, and the present invention was completed.
本発明は、少なくとも、固体状の酸性物質、前記酸性物質と反応して炭酸ガスを発生する固体状の炭酸ガス発生物質及び増粘剤を含有する一剤型皮膚外用剤であって、全皮膚外用剤中、前記増粘剤は、親水性タンパク質化合物及びその他の増粘剤を併用し、使用時に水分を含む液体と混合することを特徴とする。 The present invention is a one-part skin external preparation containing at least a solid acidic substance, a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide, and a thickening agent. In the external preparation, the thickener is used in combination with a hydrophilic protein compound and other thickeners, and is mixed with a liquid containing moisture at the time of use.
本発明によれば、低コストで、使用者が取り扱いやすく、良好な使用感及び優れた血行促進作用を有す一剤型皮膚外用剤を提供することができる。更に、本発明の一剤型皮膚外用剤は、従前の知見とは逆に増粘剤を増量したことにより、皮膚に塗布した際のざらつき感を解消でき、炭酸ガス発生による気泡が潰れにくく炭酸ガスの保持量が高いうえ、皮膚に塗布した場合の垂れ落ちもなく、有効成分の吸収促進効果を持続して得ることが可能となる。また、増粘剤に親水性タンパク質化合物及びその他増粘剤を併用することによって、気泡の強度を強くして、泡沫を長期間安定に保つことができ、更に皮膚コンディショニング効果、特に、皮膚のなめらかさ、皮膚のしっとり感、皮膚のうるおい感、皮膚の柔らかさも併せて具備させることができる。 According to the present invention, it is possible to provide a one-part skin external preparation that is low in cost, easy for a user to handle, has a good feeling of use and an excellent blood circulation promoting action. Furthermore, the one-part skin external preparation of the present invention has an increased amount of thickening agent, contrary to previous knowledge, which can eliminate the feeling of roughness when applied to the skin, and bubbles caused by carbon dioxide generation are less likely to collapse. The amount of gas retained is high, and there is no dripping when applied to the skin, and the effect of promoting the absorption of the active ingredient can be continuously obtained. In addition, by using a hydrophilic protein compound and other thickeners in combination with the thickener, the strength of the bubbles can be increased and the foam can be kept stable for a long period of time, and the skin conditioning effect, especially the smoothness of the skin, can be maintained. In addition, the skin can be moistened, the skin can be moistened, and the skin can be softened.
本発明の一剤型皮膚外用剤は、少なくとも、固体状の酸性物質、前記酸性物質と反応して炭酸ガスを発生する固体状の炭酸ガス発生物質及び増粘剤を含有する一剤型皮膚外用剤であって、前記増粘剤は、親水性タンパク質化合物及びその他の増粘剤を併用するものである。 The one-part skin external preparation of the present invention includes at least a solid acidic substance, a single-part skin external substance containing a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide and a thickener. It is an agent, Comprising: The said thickener uses a hydrophilic protein compound and another thickener together.
そして、本発明の一剤型皮膚外用剤においては、使用者が、使用時に、前記一剤型皮膚外用剤と水分を含む液体とを混合することにより炭酸ガス発生による発泡を生じせしめ、皮膚に塗布して用いるものである。本発明の皮膚外用剤は、一剤化されたことにより、二剤型のものに比べて低コストで使用者が取り扱いやすいという特徴を有す。以下、一剤型皮膚外用剤、一剤型皮膚外用剤に含まれる各構成成分及びその製法について説明する。 In the one-part skin external preparation of the present invention, the user mixes the one-part skin external preparation and a liquid containing water at the time of use, thereby causing foaming due to the generation of carbon dioxide gas. It is applied and used. Since the external preparation for skin of the present invention is made into one agent, it has a feature that the user can easily handle it at a lower cost than the two-component type. Hereinafter, each component included in the one-part skin external preparation, the one-part skin external preparation, and the production method thereof will be described.
＜一剤型皮膚外用剤＞
本発明の一剤型皮膚外用剤は、酸性物質と、酸性物質と反応して炭酸ガスを発生する炭酸ガス発生物質、及び増粘剤を含有する。好ましくは、本発明の一剤型皮膚外用剤は実質的に水分を含まない。ここで、実質的に水分を含まないとは、本発明の一剤型皮膚外用剤の保存中に酸性物質と炭酸ガス発生物質とが反応し、炭酸ガスが発生するために必要な量の水分を含まないことを言う。具体的には、本発明の一剤型皮膚外用剤中の水分含有量は１５％以下が好ましく、１０％以下がより好ましく、８％以下が特に好ましい。また、本発明の一剤型皮膚外用剤は固体状の組成物であることが好ましく、固形状、顆粒状、細粒状、粉末状の形態であることがより好ましく、水分を含む液体との混合のしやすさから、顆粒状、細粒状、粉末状の形態であることが特に好ましい。
<One-pack type external preparation for skin>
The one-part skin external preparation of the present invention contains an acidic substance, a carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide, and a thickener. Preferably, the one-part skin external preparation of the present invention does not substantially contain moisture. Here, the term “substantially free of moisture” means that the amount of moisture necessary for the generation of carbon dioxide is produced by the reaction between the acidic substance and the carbon dioxide generating substance during the storage of the one-part skin external preparation of the present invention. Say not including. Specifically, the water content in the one-part skin external preparation of the present invention is preferably 15% or less, more preferably 10% or less, and particularly preferably 8% or less. The one-part skin external preparation of the present invention is preferably a solid composition, more preferably in the form of a solid, granule, fine granule, or powder, and mixed with a liquid containing moisture. It is particularly preferable that it is in the form of granules, fine granules, or powders because of ease of treatment.
＜固体状の酸性物質＞
本発明に用いる固体状の酸性物質としては、有機酸、無機酸のいずれでもよく、これらの１種又は２種以上が用いられる。また、固体状であればどのような剤形でもよいが、顆粒状、粉末状等の粉状が好ましく、粉末状が特に好ましい。
<Solid acidic substance>
The solid acidic substance used in the present invention may be either an organic acid or an inorganic acid, and one or more of these are used. Moreover, any dosage form may be used as long as it is solid, but powders such as granules and powders are preferable, and powders are particularly preferable.
有機酸としては、ギ酸、酢酸、プロピオン酸、酪酸、吉草酸等の直鎖脂肪酸、シュウ酸、マロン酸、コハク酸、グルタル酸、アジピン酸、ピメリン酸、フマル酸、マレイン酸、フタル酸、イソフタル酸、テレフタル酸等のジカルボン酸、グルタミン酸、アスパラギン酸等の酸性アミノ酸、グリコール酸、リンゴ酸、酒石酸、クエン酸、乳酸、ヒドロキシアクリル酸、α−オキシ酪酸、グリセリン酸、タルトロン酸、サリチル酸、没食子酸、トロパ酸、アスコルビン酸、グルコン酸等のオキシ酸等があげられる。なかでも、安全性、水への溶解性の観点から、クエン酸、アスコルビン酸、リンゴ酸、コハク酸が好ましい。 Organic acids include linear fatty acids such as formic acid, acetic acid, propionic acid, butyric acid, valeric acid, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fumaric acid, maleic acid, phthalic acid, isophthalic acid Acids, dicarboxylic acids such as terephthalic acid, acidic amino acids such as glutamic acid and aspartic acid, glycolic acid, malic acid, tartaric acid, citric acid, lactic acid, hydroxyacrylic acid, α-oxybutyric acid, glyceric acid, tartronic acid, salicylic acid, gallic acid And oxyacids such as tropic acid, ascorbic acid and gluconic acid. Of these, citric acid, ascorbic acid, malic acid, and succinic acid are preferable from the viewpoints of safety and solubility in water.
＜固体状の炭酸ガス発生物質＞
本発明に用いる前記酸性物質と反応して炭酸ガスを発生する固体状の炭酸ガス発生物質としては、様々なものが特に限定されることなく使用できる。また、固体状であればどのような剤形でもよいが、顆粒状、粉末状等の粉状が好ましく、粉末状が特に好ましい。
<Solid carbon dioxide generator>
Various solid carbon dioxide generating substances that generate carbon dioxide gas by reacting with the acidic substance used in the present invention can be used without any particular limitation. Moreover, any dosage form may be used as long as it is solid, but powders such as granules and powders are preferable, and powders are particularly preferable.
前記炭酸ガス発生物質として、炭酸ナトリウム、炭酸カルシウム、炭酸カリウム、炭酸マグネシウム、セスキ炭酸ナトリウム等の炭酸塩、炭酸水素アンモニウム、炭酸水素カリウム、炭酸水素ナトリウム、炭酸水素リチウム、炭酸水素セシウム、炭酸水素マグネシウム、炭酸水素カルシウム等の炭酸水素塩等が挙げられ、これらの１種又は２種以上が用いられる。これらのうちでも、炭酸水素塩が好ましく使用でき、程よい発泡力を実現することができる点で炭酸水素ナトリウムがより好ましい。 Examples of the carbon dioxide generating substance include carbonates such as sodium carbonate, calcium carbonate, potassium carbonate, magnesium carbonate, sodium sesquicarbonate, ammonium hydrogen carbonate, potassium hydrogen carbonate, sodium hydrogen carbonate, lithium hydrogen carbonate, cesium hydrogen carbonate, magnesium hydrogen carbonate And hydrogen carbonates such as calcium hydrogen carbonate, and one or more of these are used. Among these, hydrogen carbonate is preferably used, and sodium hydrogen carbonate is more preferable in that a moderate foaming power can be realized.
前記固体状の酸性物質及び固体状の炭酸ガス発生物質は、単一の粉末あるいは顆粒状物質であっても良いし、賦形剤、顆粒化剤等の他成分との混合物からなる粉末あるいは顆粒であっても良い。 The solid acidic substance and the solid carbon dioxide generating substance may be a single powder or granular substance, or a powder or granule comprising a mixture with other components such as excipients and granulating agents. It may be.
粉末あるいは顆粒に含有できるその他の成分としては、例えば、乳糖、粉糖、澱粉、デキストリン、キシリトール、Ｄ−ソルビトール、ブドウ糖、Ｄ−マンニトール、果糖、蔗糖、白糖、尿素等の粉体を、特に制限なく、単独で、あるいは２種以上を併用して用いることができる。 Examples of other components that can be contained in the powder or granule are, for example, powders such as lactose, powdered sugar, starch, dextrin, xylitol, D-sorbitol, glucose, D-mannitol, fructose, sucrose, sucrose, urea, etc. It can be used alone or in combination of two or more.
ここで、前記酸性物質及び／又は前記炭酸ガス発生物質とその他成分との混合物を造粒することにより、前記固体状の酸性物質及び／又は前記固体状の炭酸ガス発生物質の顆粒を得る場合、その他成分の含有量としては特に制限はないが、上記顆粒中において８０質量％未満とすることが好ましい。その他成分が８０質量％を超える含有量で存在する場合、発泡性が低くなるため好ましくない。 Here, by obtaining a granule of the acidic substance and / or the carbon dioxide generating substance and other components to obtain granules of the solid acidic substance and / or the solid carbon dioxide generating substance, Although there is no restriction | limiting in particular as content of another component, It is preferable to set it as less than 80 mass% in the said granule. When other components are present in a content exceeding 80% by mass, foaming properties are lowered, which is not preferable.
前記粉末あるいは顆粒の製造方法は、本実施例に限定されることはなく、乾式破砕造粒法や湿式破砕造粒法、流動層造粒法、高速攪拌造粒法、押し出し造粒法等の常法に従い製造できる。 The method for producing the powder or granule is not limited to this example, and includes dry crushing granulation method, wet crushing granulation method, fluidized bed granulation method, high-speed stirring granulation method, extrusion granulation method and the like. It can be produced according to a conventional method.
例えば、マトリックス基剤として、顆粒化剤に低融点化合物を使用する場合は、ビーカー等の容器中で加熱により溶融させた低融点顆粒化剤に前記酸性物質及び／又は前記炭酸ガス発生物質を加えて十分攪拌、混合する。必要に応じてこれに適当な添加剤を加えてもよい。これを室温で徐々に冷やしながら更に攪拌し、固まるまで放置する。ある程度固まってきたら、冷蔵庫等で急速に冷却してもよい。 For example, when a low melting point compound is used as a granulating agent as a matrix base, the acidic substance and / or the carbon dioxide generating substance is added to the low melting point granulating agent melted by heating in a container such as a beaker. Stir and mix thoroughly. You may add an appropriate additive to this as needed. The mixture is further stirred while being cooled at room temperature, and left to solidify. Once it has solidified to some extent, it may be rapidly cooled in a refrigerator or the like.
また、例えば、流動層造粒機に上記材料を投入し、数分間気流で混合し、これに、水を噴霧することにより造粒してもよい。 Further, for example, the above materials may be put into a fluidized bed granulator, mixed by airflow for several minutes, and then granulated by spraying water.
マトリックス基剤に低融点化合物を用いない場合は、ビーカー等の容器中で顆粒化剤を水又はエタノールのような適当な溶媒に溶解又は分散させ、これに前記酸性物質及び／又は前記炭酸ガス発生物質を溶解又は分散させて十分混合した後にオーブン等で加熱して溶媒を除去し、乾燥させる。完全に固まったら粉砕し、粒の大きさを揃えるために篩過した後、顆粒とする。 When a low melting point compound is not used for the matrix base, the granulating agent is dissolved or dispersed in a suitable solvent such as water or ethanol in a container such as a beaker to generate the acidic substance and / or the carbon dioxide gas. The substance is dissolved or dispersed and sufficiently mixed, and then heated in an oven or the like to remove the solvent and dried. When it is completely hardened, it is pulverized and sieved to make the size of the granules, and then granulated.
前記固体状の酸性物質又は固体状の炭酸ガス発生物質の形状としては、例えば、不規則な形状、平面な形状、多面体形状、球状、しずく状、繊維状、円柱状、微粉状等が特に制限なく採用できる。また、その粒径としては、幅広い範囲のものが、特に制限なく使用できる。特に、取り扱いのしやすさ、粘性組成物との混合のしやすさの点から、粒径分布が１，０００μｍ程度のものがより好ましい。本発明における上記粒径分布は、通常のレーザー回折／散乱法によって求めることができる。 As the shape of the solid acidic substance or solid carbon dioxide generating substance, for example, irregular shape, planar shape, polyhedron shape, spherical shape, drop shape, fibrous shape, cylindrical shape, fine powder shape, etc. are particularly limited. Can be adopted without any problem. Moreover, the thing of the wide range can be used without a restriction | limiting especially as the particle size. In particular, those having a particle size distribution of about 1,000 μm are more preferable from the viewpoint of ease of handling and ease of mixing with the viscous composition. The particle size distribution in the present invention can be determined by a normal laser diffraction / scattering method.
＜増粘剤＞
本発明に使用される増粘剤としては、化粧料、医薬品分野において用いられ得る水溶性成分であれば特に限定されるものでなく、ポリビニルアルコール、ヒドロキシエチルセルロース、ヒドロキシプロピルメチルセルロース、スルホン化セルロース誘導体、アクリレーツ／アクリル酸アルキルクロスポリマー、ポリアクリル酸、ポリアクリルアミド、ポリアルキルアクリルアミド／ポリアクリルアミドコポリマー、カルボキシメチルセルロース、カチオン化セルロース、プルロニックをはじめとする親水性合成高分子や、デンプン、キサンタンガム、アルギン酸ナトリウム、サクシノグリカン、カラギーナン、グアーガム、ローカストビーンガム、セルロース類をはじめとする親水性天然高分子のほか、コンドロイチン硫酸塩、カゼイン、コラーゲン、ゼラチン、アルブミン、フィブロイン、エラスチン、ケラチン、セリシン等の親水性タンパク質化合物、ラポナイト、ベントナイト、スメクタイト等の親水性粘土鉱物等の親水性増粘性化合物が例示される。
<Thickener>
The thickener used in the present invention is not particularly limited as long as it is a water-soluble component that can be used in the cosmetics and pharmaceutical fields. Polyvinyl alcohol, hydroxyethyl cellulose, hydroxypropyl methylcellulose, sulfonated cellulose derivatives, Hydrophilic synthetic polymers such as acrylates / alkyl acrylate crosspolymer, polyacrylic acid, polyacrylamide, polyalkylacrylamide / polyacrylamide copolymer, carboxymethylcellulose, cationized cellulose, pluronic, starch, xanthan gum, sodium alginate, sac In addition to hydrophilic natural polymers such as sinoglycan, carrageenan, guar gum, locust bean gum and celluloses, chondroitin sulfate, casein, co- Gen, gelatin, albumin, fibroin, elastin, keratin, hydrophilic protein compounds such as sericin, laponite, bentonite, hydrophilic thickening compound such as a hydrophilic clay mineral smectite, and the like.
以上の増粘剤のなかでも、水への溶解性が高いものを用いることが、本発明の一剤型皮膚外用剤をダマを生じず均一に溶解でき、且つ、溶け残り成分に起因する肌のざらつき感を緩和することができるため好ましい。ここで、水への溶解性の良否は、室温程度の水を加え攪拌した際に、皮膚外用剤が瞬時に水に溶けて均一に溶解することによって炭酸ガスを保持するのに十分な粘度を有することや、溶解時にダマを生じないこと等から判断することができる。 Among the above thickeners, the use of one having high solubility in water makes it possible to uniformly dissolve the one-part skin external preparation of the present invention without causing lumps, and the skin caused by undissolved components This is preferable because the rough feeling can be reduced. Here, the solubility in water is determined by the fact that when the water is added at room temperature and stirred, the skin external preparation instantly dissolves in water and dissolves uniformly so that carbon dioxide gas can be retained. It can be determined from the fact that it has, or does not cause lumps during dissolution.
このような増粘剤としては、例えば、デンプン、キサンタンガム、サクシノグリカン、カラギーナン、グアーガム、ローカストビーンガム、セルロース類、ガラクタン、アラビアガム、トラガントガム、マンナン、ヒアルロン酸、カードラン、カゼイン、コラーゲン、ゼラチン、アルブミン、フィブロイン、エラスチン、ケラチン、セリシン、アルギン酸塩、カルボキシビニルポリマー、ポリビニルアルコール、ポリアクリル酸ソーダ、アクリル酸・メタクリル酸アルキル共重合体等を挙げる事ができる。 Examples of such thickeners include starch, xanthan gum, succinoglycan, carrageenan, guar gum, locust bean gum, celluloses, galactan, gum arabic, tragacanth gum, mannan, hyaluronic acid, curdlan, casein, collagen, gelatin , Albumin, fibroin, elastin, keratin, sericin, alginate, carboxyvinyl polymer, polyvinyl alcohol, sodium polyacrylate, acrylic acid / alkyl methacrylate copolymer, and the like.
増粘剤は、上記したもののうち、１種を選択して、又は、２種以上を併用して使用することができるが、２種以上を併用して使用することが好ましい。特に、親水性タンパク質化合物を、増粘剤の必須成分として含有することが好ましい。本発明において、親水性タンパク質化合物とは、水分を含む液体に可溶なタンパク質化合物のことを言い、本発明においては、単一原料のみでなく、これらの加水分解物、これらを含む天然物やその抽出物も使用できる。親水性タンパク質化合物は発泡助剤としての役割も有し、特に気泡の強度を強くして、泡沫を長期間安定に保つ働きを有する。そのため、親水性タンパク質化合物を必須の増粘剤とし、単独で、あるいは、これと他の増粘剤とを併用することにより、皮膚外用剤の粘度調節の容易性や水への溶解性を向上でき、更に皮膚コンディショニング効果、特に、皮膚のなめらかさ、皮膚のしっとり感、皮膚のうるおい感、皮膚の柔らかさも併せて具備させることができる。親水性タンパク質化合物のなかでもカゼイン、コラーゲン、ゼラチン、アルブミン、フィブロイン、エラスチン、ケラチン、セリシンが好ましく、特にコラーゲン、ゼラチン、アルブミン、フィブロインが好ましく、最も好ましいのはアルブミン、コラーゲンである。 A thickener can be used by selecting 1 type from among the above, or using 2 or more types together, but it is preferable to use 2 or more types in combination. In particular, it is preferable to contain a hydrophilic protein compound as an essential component of the thickener. In the present invention, the hydrophilic protein compound refers to a protein compound that is soluble in a water-containing liquid. In the present invention, not only a single raw material but also a hydrolyzate thereof, a natural product containing these, The extract can also be used. The hydrophilic protein compound also has a role as a foaming aid, and in particular has a function of increasing the strength of bubbles and keeping the foam stable for a long period of time. Therefore, using hydrophilic protein compounds as essential thickeners alone or in combination with other thickeners improves the ease of adjusting the viscosity and solubility in water of topical skin preparations. Furthermore, skin conditioning effects, in particular, smooth skin, moist skin, moist skin, and soft skin can be provided. Among the hydrophilic protein compounds, casein, collagen, gelatin, albumin, fibroin, elastin, keratin, and sericin are preferable, and collagen, gelatin, albumin, and fibroin are particularly preferable, and albumin and collagen are most preferable.
本発明に使用される増粘剤は、水分を含む液体との混合比に応じて適宜設定すれば良いが、全皮膚外用剤中に１０〜５０質量％で含有されることが好ましく、１２〜４５質量％であることがより好ましい。上記含有量が少ないと、前記皮膚外用剤と水分を含む液体との混合時に、未溶解成分に起因するざらつき感が生じやすいため、使用感が損なわれる。また、垂れ落ちが生じやすく密着性に欠けるため、十分な血行促進作用を得ることができなくなる。一方、増粘剤含有量が上記範囲を超えて多いと、水への溶解性に劣りダマを発生して肌への塗布時に不快感を生じ、十分な血行促進作用を得ることができなくなる。 The thickener used in the present invention may be appropriately set according to the mixing ratio with the liquid containing water, but is preferably contained at 10 to 50% by mass in the whole skin external preparation, More preferably, it is 45 mass%. When the content is small, a feeling of roughness is likely to occur due to undissolved components when the skin preparation for external use and a liquid containing water are mixed. Moreover, since it is liable to sag and lacks adhesion, a sufficient blood circulation promoting action cannot be obtained. On the other hand, if the content of the thickener exceeds the above range, the solubility in water is inferior, causing lumps, causing discomfort when applied to the skin, and sufficient blood circulation promoting action cannot be obtained.
上記増粘剤のなかでも、親水性タンパク質化合物の含有量は、全皮膚外用剤中に０．５〜４５質量％で含有されることが好ましく、１〜３０質量％であることがより好ましく、１〜１０質量％で含有されることが特に好ましい。 Among the thickeners, the content of the hydrophilic protein compound is preferably 0.5 to 45% by mass, more preferably 1 to 30% by mass in the whole skin external preparation. It is particularly preferable that the content is 1 to 10% by mass.
上記増粘剤において、親水性タンパク質化合物と併用するその他増粘剤は、上記増粘剤の中から任意に選択し、利用できるが、親水性合成高分子又は親水性天然高分子から少なくとも１種類以上を用いることが好ましい。親水性合成高分子又は親水性天然高分子としては、ポリビニルアルコール、ヒドロキシエチルセルロース、ヒドロキシプロピルメチルセルロース、スルホン化セルロース誘導体、アクリレーツ／アクリル酸アルキルクロスポリマー、ポリアクリル酸、ポリアクリルアミド、ポリアルキルアクリルアミド／ポリアクリルアミドコポリマー、カルボキシメチルセルロース、カチオン化セルロース、プルロニック、デンプン、キサンタンガム、アルギン酸ナトリウム、サクシノグリカン、カラギーナン、グアーガム、ローカストビーンガム、セルロース類などが挙げられる。上記増粘剤において、その他増粘剤の配合量は適宜設定すれば良いが、全皮膚外用剤中に１質量％以上含有されることが好ましく、５質量％以上含有されることがより好ましく、７質量％以上含有されることが特に好ましい。 In the above thickener, the other thickener used in combination with the hydrophilic protein compound can be arbitrarily selected from the above thickeners and can be used, but at least one kind selected from the hydrophilic synthetic polymer or the hydrophilic natural polymer. It is preferable to use the above. Examples of hydrophilic synthetic polymers or hydrophilic natural polymers include polyvinyl alcohol, hydroxyethylcellulose, hydroxypropylmethylcellulose, sulfonated cellulose derivatives, acrylates / alkyl acrylate crosspolymers, polyacrylic acid, polyacrylamide, polyalkylacrylamide / polyacrylamide. Copolymers, carboxymethylcellulose, cationized cellulose, pluronic, starch, xanthan gum, sodium alginate, succinoglycan, carrageenan, guar gum, locust bean gum, celluloses and the like. In the above thickener, the blending amount of the other thickener may be set as appropriate, but it is preferably 1% by mass or more, more preferably 5% by mass or more, in the whole skin external preparation. It is particularly preferable that the content is 7% by mass or more.
化粧品（パック等）の技術分野においては、増粘剤の増量は、その伸びや溶解性の低下、カスの発生等の不具合を引き起こすとされており、増粘剤は１質量％未満で使用されることがこの分野では一般的であった。そのため、従前の炭酸パックでも、その使用量は２〜３質量％程度にとどまっていた。これに対し、本発明では、当業者の有す従前の知見とは逆に多くの増粘剤を一剤型皮膚外用剤に含有させることにより、意外にも皮膚に塗布した際のざらつき感を解消でき、更に、炭酸ガス発生による気泡が潰れにくくなって炭酸ガスの保持量が高められ、皮膚に塗布した場合の垂れ落ちもなくなって、有効成分の吸収促進効果を持続して得られることを可能とした。 In the technical field of cosmetics (packs, etc.), increasing the amount of thickener is said to cause problems such as elongation, a decrease in solubility, and generation of residue, and the thickener is used at less than 1% by mass. It was common in this field. For this reason, even in the conventional carbonic acid pack, the amount used was limited to about 2 to 3% by mass. On the other hand, in the present invention, contrary to the previous knowledge possessed by those skilled in the art, by adding a lot of thickeners to the one-part skin external preparation, the rough feeling when applied to the skin unexpectedly is obtained. In addition, it is difficult to collapse the bubbles due to the generation of carbon dioxide, the amount of carbon dioxide retained is increased, and no dripping occurs when applied to the skin, and the effect of promoting the absorption of active ingredients can be obtained continuously. It was possible.
＜その他の成分＞
本発明の一剤型皮膚外用剤は、用途や目的に応じ、前記固体状の酸性物質、前記固体状の炭酸ガス発生物質及び増粘剤に加え、その他有効成分、ｐＨ調整剤、油脂、香料、着色剤、酸化防止剤、防菌防かび剤、アルコール、多価アルコール、非イオン界面活性剤、アニオン界面活性剤、カチオン界面活性剤、両性界面活性剤、無機塩、滑沢剤、溶剤等の、通常皮膚外用剤に使用される成分の一種以上と共に混合することができる。
<Other ingredients>
The one-part skin external preparation of the present invention comprises, in addition to the solid acidic substance, the solid carbon dioxide generating substance and the thickener, other active ingredients, pH adjusting agents, fats and oils, depending on the application and purpose. , Colorants, antioxidants, fungicides, fungicides, alcohols, polyhydric alcohols, nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, inorganic salts, lubricants, solvents, etc. It can be mixed with at least one of the components usually used in external preparations for skin.
以下、本発明の前記皮膚外用剤に含有される、固体状の酸性物質、固体状の炭酸ガス発生物質及び増粘剤以外の成分の代表的なものについて更に説明する。 Hereinafter, representative components other than the solid acidic substance, the solid carbon dioxide generating substance and the thickener contained in the external preparation for skin of the present invention will be further described.
本発明に使用される有効成分としては、特に限定されることなく、通常化粧品、外用医薬品、医薬部外品等に用いられる薬剤や植物等を目的に応じ使用することができる。代表的なものとして、例えば、グリチルリチン酸又はその誘導体、胎盤抽出物等の美白剤、プロピレングリコール、ポリエチレングリコール、ソルビトール、乳酸ナトリウム、ピロリドンカルボン酸ナトリウム等の保湿成分、甘草等の植物成分等が挙げられる。なお、植物成分としては、その全草、葉（葉身、葉柄等）、果実（成熟、未熟等）、種子、花（花弁、子房等）、茎、根茎、根、塊根等を、そのまま、切断、破砕、粉砕、搾取、抽出して用いるか、又はこれら処理されたものを乾燥若しくは粉末化して用いることができる。抽出物は、抽出溶媒として水分を含む場合もあるが、本発明の一剤型皮膚外用剤の保存中に酸性物質と炭酸ガス発生物質とが反応し、炭酸ガスが発生するために必要な量の水分を含まなければ実質的に水分を含むことにはならないため、水分を含む抽出溶媒を使用することもできる。 The active ingredient used in the present invention is not particularly limited, and drugs, plants, and the like that are usually used in cosmetics, external medicines, quasi drugs, and the like can be used according to the purpose. Typical examples include, for example, glycyrrhizic acid or derivatives thereof, whitening agents such as placenta extract, moisturizing ingredients such as propylene glycol, polyethylene glycol, sorbitol, sodium lactate, sodium pyrrolidonecarboxylate, and plant components such as licorice. It is done. As plant components, the whole plant, leaves (leaf blades, petiole, etc.), fruits (mature, immature, etc.), seeds, flowers (petals, ovary, etc.), stems, rhizomes, roots, tuberous roots, etc., are used as they are. It can be used by cutting, crushing, crushing, squeezing, extracting, or using these processed or dried powder. The extract may contain water as an extraction solvent, but the amount necessary for the generation of carbon dioxide by reacting the acidic substance and carbon dioxide generating substance during storage of the one-part skin external preparation of the present invention. Therefore, an extraction solvent containing moisture can be used.
＜皮膚外用剤の使用形態＞
本発明の一剤型皮膚外用剤は、剤中に実質的に水分を含まず、使用に際し、手のひらの上あるいは容器内で水分を含む液体と混合することにより発泡を生じさせる。
<Usage form of external preparation for skin>
The one-part skin external preparation of the present invention does not substantially contain moisture in the preparation, and in use, foaming is caused by mixing with a liquid containing moisture on the palm or in a container.
本発明に使用される水分を含む液体としては、通常、化粧品、医薬品等に用いられる水、一般家庭で使用する水の他、水分を含む液体であれば、特に制限なくあらゆる液体を使用することができる。例えば、水道水、蒸留水、膜濾過水、イオン交換水、海洋深層水の他、日本酒、ワイン等の酒類、豆乳、飲むヨーグルト、アセロラジュース、スポーツ飲料、炭酸水等の飲料、米のとぎ汁等が挙げられる。これらは、単独で使用しても、２種以上を混合して使用してもかまわない。 As the liquid containing water used in the present invention, any liquid can be used without particular limitation as long as it is a liquid containing water in addition to water used in cosmetics, pharmaceuticals, etc., water used in general households. Can do. For example, tap water, distilled water, membrane filtered water, ion exchange water, deep ocean water, sake, wine such as sake, soy milk, drink yogurt, acerola juice, sports drink, carbonated water drink, rice tofu, etc. Is mentioned. These may be used alone or in combination of two or more.
使用する水分を含む液体の量は、特に限定されることなく広い範囲で使用することが可能であるが、皮膚外用剤に対し重量で１〜１０倍量で加えることが好ましく、２〜５倍量加えることが一層好ましい。１倍量を超える液体を加えることにより、迅速に皮膚外用剤を溶解することができ、又、十分な量の炭酸ガスを発生させることができる。一方、液体を１０倍量以内で加えることにより、皮膚外用剤の粘度低下による垂れ落ちを防止することができる。 The amount of water-containing liquid used is not particularly limited and can be used in a wide range, but it is preferably added in an amount of 1 to 10 times by weight with respect to the external preparation for skin, and 2 to 5 times. It is more preferable to add the amount. By adding more than 1 times the amount of liquid, the external preparation for skin can be quickly dissolved, and a sufficient amount of carbon dioxide gas can be generated. On the other hand, dripping due to a decrease in viscosity of the external preparation for skin can be prevented by adding the liquid within 10 times the amount.
使用する水分を含む液体の温度は、特に限定されることなく広い範囲が使用できるが、予め冷却して使用することが、一剤型皮膚外用剤の有す有効成分の働きが高くなるため特に好ましい。使用できる温度範囲は、塗布時の使用感や使用者の利便性の観点から、室温程度の水や水道水を使用するのが好ましい。 The temperature of the liquid containing the moisture to be used is not particularly limited and can be used in a wide range. However, since the action of the active ingredient of the one-part skin external preparation is enhanced, it is particularly useful to cool in advance. preferable. The usable temperature range is preferably water at about room temperature or tap water from the viewpoint of usability during application and user convenience.
皮膚外用剤を保存する方法としては、水分を遮断し接触しない状態で保存されていれば、特に制限はない。使用される保存容器の形状は、目的に応じて適宜選択でき、カップ状、チューブ状、バッグ状、瓶状、スティック状、ポンプ状、ジャー状、缶詰状等が挙げられる。また、保存容器を構成する材料は、例えば、プラスチック、ガラス、アルミニウム、紙、各種ポリマー等を単独あるいは２種以上選択して用いることができるが、これらに限定されない。 The method for preserving the external preparation for skin is not particularly limited as long as it is stored in a state where it blocks moisture and does not come into contact. The shape of the storage container to be used can be appropriately selected according to the purpose, and examples thereof include cup shape, tube shape, bag shape, bottle shape, stick shape, pump shape, jar shape, and canned shape. Moreover, the material which comprises a storage container can use plastics, glass, aluminum, paper, various polymers, etc. individually or in combination of 2 or more types, for example, It is not limited to these.
容器の具体例としては、密閉性、内容物の保存安定性、製造コスト等の点で、内面をポリエチレンテレフタレートでラミネートしたアルミスティック、アルミバッグ等の保存容器、チャック付きスタンドパウチ、内面をポリエチレンテレフタレートでラミネートしたアルミフィルム等で蓋をヒートシールしたポリエチレンテレフタレート製の保存容器等が好ましい。 Specific examples of containers include: aluminum sticks laminated with polyethylene terephthalate on the inner surface, storage bags such as aluminum bags, stand pouch with chuck, polyethylene terephthalate on the inner surface in terms of hermeticity, storage stability of contents, manufacturing cost, etc. A storage container made of polyethylene terephthalate in which the lid is heat-sealed with an aluminum film or the like laminated with is preferable.
＜皮膚外用剤の用途＞
本発明の皮膚外用剤は、皮膚血流量の増加、皮膚のコンディショニング効果を促すものであり、美白、肌質改善、そばかす改善、肌の若返り、肌の引き締め、部分痩せ、皮膚を清浄にする、肌を整える、肌のキメを整える、皮膚をすこやかに保つ、肌荒れを防ぐ、肌をひきしめる、皮膚にうるおいを与える、皮膚の水分，油分を補い保つ、皮膚の柔軟性を保つ、皮膚を保護する、皮膚に乾燥を防ぐ、肌を柔らげる、肌にはりを与える、肌にツヤを与える、肌を滑らかにする、日やけによるシミ・ソバカスを防ぐことを目的とした化粧品だけでなく、肌あれ、あれ性、あせも・しもやけ・ひび・あかぎれ・にきびの予防、油症肌、かみそりまけの予防、日やけによるしみ・そばかすの予防、日やけ・雪やけ後のほてりを防ぐ、肌をひきしめる、肌を清浄にする、肌を整える、皮膚をすこやかに保つ、皮膚にうるおいを与える、皮膚を保護する、皮膚の乾燥を防ぐ等の目的で医薬部外品、薬品等の医薬品のいずれにも好適に使用することができる。使用形態としては乳液、クリーム、パック、ピーリング剤等の化粧品又は医薬部外品として使用することが好ましく、パックとして使用することがより好ましい。
<Uses of external preparations for skin>
The topical skin preparation of the present invention promotes an increase in skin blood flow and a skin conditioning effect. Prepares the skin, smoothes the skin, keeps the skin healthy, prevents rough skin, tightens the skin, moisturizes the skin, keeps skin moisture and oil, keeps the skin soft, protects the skin Not only cosmetics intended to prevent skin dryness, soften skin, give skin elasticity, give skin gloss, smooth skin, sunburn spots and freckles, but also skin That, it's nature, prevention of ash, wrinkles, cracks, redheads, acne, oily skin, prevention of razor ablation, prevention of spots / freckle caused by sunburn, sunburn / burn after sunburn, squeeze the skin, Suitable for both quasi-drugs and drugs such as pharmaceuticals for the purpose of cleansing, conditioning the skin, keeping the skin healthy, moisturizing the skin, protecting the skin, preventing the skin from drying out, etc. Can be used. It is preferable to use it as cosmetics or quasi-drugs such as emulsions, creams, packs, and peeling agents, and more preferably as packs.
最適な増粘剤量範囲を求めるに先立ち、下記表１に示した参考例１をまず作成し、泡の状態を確認した。これに各種増粘剤及びその他成分を追加して、発泡の状態を観察した。親水性タンパク質化合物としてアルブミンを選択すると、表１に参考例２として記載したように、気泡の強度が特に高まり、泡が潰れにくくなる現象が観察された。アルブミンでない他の増粘剤を追加した場合でも、気泡の強度以外の、溶解性、垂れ、保持可能炭酸量の評価結果については、アルブミンを追加した場合と大きく異ならないと考えられる。 Prior to obtaining the optimum thickener amount range, Reference Example 1 shown in Table 1 below was first prepared, and the state of foam was confirmed. Various thickeners and other components were added to this, and the state of foaming was observed. When albumin was selected as the hydrophilic protein compound, as described in Table 1 as Reference Example 2, a phenomenon in which the strength of the bubbles was particularly increased and the bubbles were not easily crushed was observed. Even when other thickeners that are not albumin are added, the evaluation results of solubility, sagging, and the amount of carbon dioxide that can be retained other than the strength of the bubbles are considered not to be significantly different from the case of adding albumin.
以下、実施例を示して本発明を更に具体的に説明するが、本発明の範囲は、これらの実施例に限定されるものではない。 EXAMPLES Hereinafter, although an Example is shown and this invention is demonstrated further more concretely, the scope of the present invention is not limited to these Examples.
＜実施例１〜５、比較例１〜４＞
表２に示した組成に従い、増粘剤を１２、１５、２０、２５、４５質量％含有した実施例１〜５の一剤型皮膚外用剤、及び、増粘剤を５、６、１０、５５質量％含有した比較例１〜４の一剤型皮膚外用剤を製造した。
<Examples 1-5, Comparative Examples 1-4>
According to the composition shown in Table 2, the one-part skin external preparations of Examples 1 to 5 containing 12, 15, 20, 25, 45% by weight of the thickener, and 5, 6, 10, One-part skin external preparations of Comparative Examples 1 to 4 containing 55% by mass were produced.
下記要領に従い、上記の実施例及び比較例の一剤型皮膚外用剤の特性を評価した。
＜ざらつきの評価＞
粉末状の一剤型皮膚外用剤試料と水を１：３（重量比）で容器中にて混合し、その感触を下記基準に基づき評価する。
○ 塗布時及び使用中にざらつき感や不快感を全く受けない。
△ 塗布時に僅かにざらつきを感じるものの、使用中には不快感がない。
× 塗布時及び使用中にざらつき感や不快感がある。
According to the following procedure, the properties of the one-part skin external preparations of the above Examples and Comparative Examples were evaluated.
<Roughness evaluation>
A powdery one-part skin external preparation sample and water are mixed at 1: 3 (weight ratio) in a container, and the feel is evaluated based on the following criteria.
○ No rough or uncomfortable feeling during application or use.
△ Although slightly rough at the time of application, there is no discomfort during use.
× There is a feeling of roughness and discomfort during application and use.
＜溶解性の評価＞
粉末状の一剤型皮膚外用剤試料と水を１：３（重量比）で容器中にて混合し、攪拌中目視による観察を行い下記基準に基づき評価する。
○ 混合後直ちに粉末が均一に溶解し、ダマを生じない。
△ 混合後直ちに粉末が吸水してゲル化し、一部にダマを生じる。
× 混合後直ちに粉末が吸水してゲル化し、ダマ状となる。
<Evaluation of solubility>
A powdery one-part skin external preparation sample and water are mixed in a container at a ratio of 1: 3 (weight ratio), visually observed during stirring, and evaluated based on the following criteria.
○ Immediately after mixing, the powder dissolves uniformly and does not cause lumps.
Δ Immediately after mixing, the powder absorbs water and gels, producing some lumps.
X Immediately after mixing, the powder absorbs water and gels, resulting in a lumpy shape.
＜垂れの評価＞
粉末状の一剤型皮膚外用剤試料と水を１：３（重量比）で容器中にて混合し、垂直に立てた人の腕に混合物を塗布して肌上の混合物の垂れ落ち具合を観察し、下記基準に基づき評価する。
○ 塗布後、一定時間経過しても垂れ落ちが生じず、混合物が肌に留まる。
△ 塗布後１分後には垂れ落ちが生じ、混合物の一部は肌に留まらない。
× 塗布後すぐに垂れ落ちて、ほとんど肌に留まらない。
<Evaluation of sagging>
The powdered one-part skin external preparation sample and water were mixed in a container at a ratio of 1: 3 (weight ratio), and the mixture was applied to a person's arm standing vertically to prevent the mixture from dripping. Observe and evaluate based on the following criteria.
○ After application, no dripping occurs even after a certain period of time, and the mixture stays on the skin.
△ One minute after application, dripping occurs and a part of the mixture does not stay on the skin.
× Dripping immediately after application, hardly stays on the skin.
＜一剤型皮膚外用剤の炭酸ガス発泡量の評価＞
直径約４．８ｃｍ、高さ約１０．５ｃｍの容量２２５ｍＬの瓶に水２１ｇを計りとり、これに粉末状の一剤型皮膚外用剤試料７ｇを加えて、１０秒間に２０回攪拌した。撹拌前、攪拌直後、１分後、１０分後、２０分後の体積を測定し、攪拌前の体積に対する体積の増加率を測定した。その結果を、図１に示す。また、２０分後の炭酸ガスの体積増加率を、保持可能炭酸量とした。
<Evaluation of the amount of carbon dioxide foaming of a one-part skin external preparation>
21 g of water was weighed in a 225 mL bottle having a diameter of about 4.8 cm and a height of about 10.5 cm, and 7 g of a powdery one-part skin external preparation sample was added thereto and stirred 20 times for 10 seconds. Before stirring, immediately after stirring, after 1 minute, after 10 minutes, and after 20 minutes, the volume was measured, and the increase rate of the volume with respect to the volume before stirring was measured. The result is shown in FIG. Moreover, the volume increase rate of the carbon dioxide gas after 20 minutes was made into the carbon dioxide amount which can be hold | maintained.
表３に、上記のざらつき、溶解性、垂れ、及び保持可能炭酸量の各評価結果と、これらの結果から判断できる一剤型皮膚外用剤の総合的な評価結果を示す。 In Table 3, each evaluation result of said roughness, solubility, sagging, and the amount of carbonic acid which can be hold | maintained, and the comprehensive evaluation result of the one agent type skin external preparation which can be judged from these results are shown.
増粘剤を５％含む比較例１及び６％含む比較例２の皮膚外用剤については、ざらつき感を有し、垂れ落ちも生じ、混合物中に保持できる炭酸ガスの量も著しく少なかった。また、増粘剤を１０％含む比較例３の皮膚外用剤であっても、垂れ落ちを生じた。一方、増粘剤を５５％含む比較例４の皮膚外用剤は溶解性が著しく劣り、ゲル化やダマの発生が認められ、混合物中に保持できる炭酸ガスの量もあまり多くなかった。混合物中に保持できる炭酸ガスの量は、図１からみて、実施例４＞実施例２、３≒比較例３＞実施例５≒比較例４＞比較例１、２の順に優れていた。以上の結果を総合的に評価すると、増粘剤を１２〜４５質量％含む本発明の実施態様である実施例１〜４の皮膚外用剤が、比較例のものに比べて皮膚外用剤として優れることが分かった。 The external preparation for skin of Comparative Example 1 containing 5% of the thickener and Comparative Example 2 containing 6% had a rough feeling, dripping occurred, and the amount of carbon dioxide gas that could be retained in the mixture was remarkably small. Moreover, even if it was the skin external preparation of the comparative example 3 which contains 10% of thickeners, dripping occurred. On the other hand, the external preparation for skin of Comparative Example 4 containing 55% of a thickener was remarkably inferior in solubility, generation of gelation and lumps was observed, and the amount of carbon dioxide gas that could be retained in the mixture was not very large. The amount of carbon dioxide gas that can be held in the mixture was excellent in the order of Example 4> Example 2, 3≈Comparative Example 3> Example 5≈Comparative Example 4> Comparative Examples 1 and 2 as seen from FIG. When the above results are comprehensively evaluated, the skin external preparations of Examples 1 to 4 which are embodiments of the present invention containing 12 to 45% by mass of the thickener are superior as the skin external preparations compared to the comparative examples. I understood that.
上記検討から明らかなように、本発明の皮膚外用剤は、増粘剤を従前の外用剤に比べ高配合に含有することにより、炭酸ガスの保持性や垂れ落ち性の改善に加えて、ざらつき感の防止という効果を奏する。 As is clear from the above examination, the skin external preparation of the present invention contains a thickener in a higher composition than conventional external preparations, in addition to improving the retention of carbon dioxide gas and the dripping property, it is rough. It has the effect of preventing feeling.
＜実施例６〜７、比較例５〜７＞
表４に示した組成に従い、一剤型皮膚外用剤を製造した。
<Examples 6-7, Comparative Examples 5-7>
According to the composition shown in Table 4, a one-part skin external preparation was produced.
得られた一剤型皮膚外用剤について、炭酸ガス発泡量（体積増加率、保持可能炭酸量）、皮膚コンディショニング効果（皮膚のなめらかさ、皮膚のしっとり感、皮膚のうるおい感、皮膚の柔らかさ）、角層水分量について評価を実施した。評価の際は、表４の組成に従い調製した一剤型皮膚外用剤と水を１：３（重量比）で容器中にて混合して使用した。 About the obtained one-part skin external preparation, the amount of carbon dioxide foam (volume increase rate, the amount of carbon dioxide that can be retained), skin conditioning effect (smooth skin, moist skin, moist skin, soft skin) The stratum corneum moisture content was evaluated. In the evaluation, the one-part skin external preparation prepared according to the composition shown in Table 4 and water were mixed in a container at a ratio of 1: 3 (weight ratio).
＜一剤型皮膚外用剤の炭酸ガス発泡量の評価＞
直径約４．８ｃｍ、高さ約１０．５ｃｍの容量２２５ｍＬの瓶に水３０ｇを計りとり、これに粉末状の一剤型皮膚外用剤試料１０ｇを加え、１０秒間に２０回攪拌した。撹拌前、攪拌直後、１分後、１０分後、２０分後の体積を測定し、攪拌前の体積に対する体積の増加率を測定した。その結果を、図２に示す。また、２０分後の炭酸ガスの体積増加率を、保持可能炭酸量とした。
<Evaluation of the amount of carbon dioxide foaming of a one-part skin external preparation>
30 g of water was weighed into a 225 mL bottle having a diameter of about 4.8 cm and a height of about 10.5 cm, and 10 g of a powdery one-part skin external preparation sample was added thereto and stirred 20 times for 10 seconds. Before stirring, immediately after stirring, after 1 minute, after 10 minutes, and after 20 minutes, the volume was measured, and the increase rate of the volume with respect to the volume before stirring was measured. The result is shown in FIG. Moreover, the volume increase rate of the carbon dioxide gas after 20 minutes was made into the carbon dioxide amount which can be hold | maintained.
＜皮膚コンディショニング効果の評価＞
２０〜３０代女性５名を被験者とし、アンケートにて評価を実施した。評価は以下の要領で行った。被験者の前腕内側を洗顔料で洗浄し、測定室にて１５分間安静に過ごした。続いて、上記前腕内側の４ｃｍ×４ｃｍの範囲に水と混合した一剤型皮膚外用剤を１０分間塗布し、静置した。続いて１０分後、塗布した一剤型皮膚外用剤を除去し、水で洗浄した。その後、肌のなめらかさ、肌のしっとり感、肌のうるおい感、皮膚の柔らかさの４項目についてアンケートを実施した。各項目について、比較例７を規準とし、（４点）として表５に示す７段階に点数をつけ、５名の平均値を求めた。
<Evaluation of skin conditioning effect>
Five females in their 20s and 30s were subjects, and the evaluation was conducted through a questionnaire. Evaluation was performed as follows. The inner side of the subject's forearm was washed with face wash and rested in the measurement room for 15 minutes. Subsequently, a one-part skin external preparation mixed with water was applied for 10 minutes in the range of 4 cm × 4 cm inside the forearm and allowed to stand. Subsequently, after 10 minutes, the applied one-part skin external preparation was removed and washed with water. Thereafter, a questionnaire was conducted on four items: smooth skin, moist skin, moist skin, and soft skin. For each item, the comparative example 7 was used as a standard, and a score was assigned to 7 levels shown in Table 5 as (4 points), and an average value of 5 people was obtained.
＜角層水分量の評価＞
角層水分量は、２０〜３０代女性５名を被験者とし、一剤型皮膚外用剤の使用前後の角層水分量を測定することで評価を実施した。評価は以下の要領で行った。被験者の前腕内側を洗顔料で洗浄し、測定室にて１５分間安静に過ごした。その後、前腕内側の４ｃｍ×４ｃｍの範囲の角層水分量を皮表角層水分量測定装置（アイ・ビイ・エス株式会社製：ＳＫＩＣＯＮ−２００ＥＸ）で測定し、一剤型皮膚外用剤の使用前の測定値とした。上記皮表角層水分量測定装置は、角層の水分量を電導度で評価したものである。続いて、上記前腕内側に、前腕内側の４ｃｍ×４ｃｍの範囲に水と混合した一剤型皮膚外用剤を１０分間塗布し、静置した。続いて１０分後、塗布した一剤型皮膚外用剤を除去し、水で洗浄した。洗浄後１５分経過後、一剤型皮膚外用剤使用後の角層水分量を測定した。得られた結果において、一剤型皮膚外用剤使用前の値を１とし、使用後の変化率を算出した。
<Evaluation of moisture content in stratum corneum>
The stratum corneum water content was evaluated by measuring the water content of the stratum corneum before and after the use of the one-part skin external preparation, with 5 females in their 20s to 30s as subjects. Evaluation was performed as follows. The inner side of the subject's forearm was washed with face wash and rested in the measurement room for 15 minutes. Thereafter, the water content of the stratum corneum in the range of 4 cm × 4 cm on the inner side of the forearm was measured with a skin surface stratum corneum water content measuring device (manufactured by IBS Co., Ltd .: SKICON-200EX). The previous measured value was used. The skin surface stratum corneum water content measuring apparatus is an apparatus for evaluating the water content of the stratum corneum by electrical conductivity. Subsequently, a one-part skin external preparation mixed with water was applied to the inside of the forearm in a range of 4 cm × 4 cm inside the forearm for 10 minutes and allowed to stand. Subsequently, after 10 minutes, the applied one-part skin external preparation was removed and washed with water. After 15 minutes from the washing, the amount of water in the stratum corneum after using the one-pack type skin external preparation was measured. In the obtained results, the value before use of the one-pack type external preparation for skin was set to 1, and the change rate after use was calculated.
実施例６〜７、比較例５〜７について、得られた結果を図２、表６、図３に示す。 The results obtained for Examples 6 to 7 and Comparative Examples 5 to 7 are shown in FIG. 2, Table 6, and FIG.
図２より、増粘剤として親水性タンパク質化合物及びその他増粘剤を使用した実施例６、７は他の一剤型皮膚外用剤と比べて体積増加率が高く、また、その泡沫を２０分後も保持できることが確認できた。これに対し、単独の増粘剤を有する比較例５〜７では、いずれも１０分後、２０分後の体積増加率は１分後に比べて同等か、あるいは小さくなっており、１０分以降泡沫を保持できないことがわかった。
また、表６より、実施例６、７は、いずれも比較例７の一剤型皮膚外用剤に比べて肌のなめらかさ、肌のしっとり感、肌のうるおい感、皮膚の柔らかさのいずれの項目も優れていることがわかった。これに対し、増粘剤として一種類のみを含有する比較例５及び６は、いずれの評価結果も比較例７と同程度であった。
また、図３より、角層水分量を測定した結果、実施例６、７では、いずれも角層水分量が大幅に増加し、比較例５〜７の一剤型皮膚外用剤は、いずれも、使用前後の角層水分量の増加は小さくなったことがわかった。
From FIG. 2, Examples 6 and 7 using a hydrophilic protein compound and other thickeners as the thickener have a higher volume increase rate than other one-part skin external preparations, and the foam is kept for 20 minutes. It was confirmed that it could be retained later. On the other hand, in Comparative Examples 5 to 7 having a single thickener, the volume increase rate after 10 minutes and after 20 minutes is equal to or smaller than that after 1 minute. I can't hold it.
Also, from Table 6, Examples 6 and 7 are any of smoothness of skin, moist feeling of skin, moist feeling of skin, and softness of skin as compared with one-part skin external preparation of Comparative Example 7. The item was found to be excellent. On the other hand, Comparative Examples 5 and 6 containing only one kind as a thickener were comparable to Comparative Example 7 in both evaluation results.
In addition, as a result of measuring the stratum corneum moisture content from FIG. 3, in Examples 6 and 7, the stratum corneum moisture content is significantly increased, and the one-part skin external preparations of Comparative Examples 5 to 7 are all It was found that the increase in stratum corneum moisture before and after use was small.
以上の結果から、補正後の本願発明の一剤型皮膚外用剤は、増粘剤として、親水性タンパク質化合物とその他の増粘剤を併用することにより、気泡の強度を強くして、泡沫を長期間安定に保ち、顕著な皮膚コンディショニング効果を有することがわかった。 Based on the above results, the one-part skin external preparation of the present invention after correction has a strong foam strength by using a hydrophilic protein compound and other thickeners in combination as a thickener. It was found to be stable for a long time and to have a significant skin conditioning effect.
［一剤型皮膚外用剤の処方例］
以下に、更に、本発明の一剤型皮膚外用剤の具体的な処方例を示す。
＜実施例８＞
表７記載の配合割合で各成分を配合し、粉末状の一剤型皮膚外用剤とした。この一剤型皮膚外用剤粉を容器にとり、粉１に対し、重量比で３の水を加えて攪拌したところ、泡状のパック化粧料が得られた。
[Prescription example of one-part skin external preparation]
The specific formulation example of the one-part skin external preparation of this invention is shown below further.
<Example 8>
Each component was mix | blended with the compounding ratio of Table 7, and it was set as the powdery one-part type skin external preparation. When this one-part type skin external preparation powder was put in a container, and water of 3 by weight was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.
＜実施例９＞
表８記載の配合割合で各成分を配合し、粉末状の一剤型皮膚外用剤とした。この一剤型皮膚外用剤粉を容器にとり、粉１に対し、重量比で３の水を加えて攪拌したところ、泡状のパック化粧料が得られた。
<Example 9>
Each component was mix | blended with the mixture ratio of Table 8, and it was set as the powdery one-pack type skin external preparation. When this one-part type skin external preparation powder was put in a container, and water of 3 by weight was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.
＜実施例１０＞
表９記載の配合割合で各成分を配合し、粉末状の一剤型皮膚外用剤とした。この一剤型皮膚外用剤粉を容器にとり、粉１に対し、重量比で１の水を加えて攪拌したところ、泡状のパック化粧料が得られた。
<Example 10>
Each component was mix | blended with the mixture ratio of Table 9, and it was set as the powdery one-part type skin external preparation. When this one-part type skin external preparation powder was placed in a container and 1 weight of water was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.
＜実施例１１＞
表１０記載の配合割合で各成分を配合し、粉末状の一剤型皮膚外用剤とした。この一剤型皮膚外用剤粉を容器にとり、粉１に対し、重量比で１０の水を加えて攪拌したところ、泡状のパック化粧料が得られた。
<Example 11>
Each component was mix | blended with the compounding ratio of Table 10, and it was set as the powdery one-part skin external preparation. When this one-part type skin external preparation powder was placed in a container and 10 weight-percent water was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.
＜実施例１２＞
表１１記載の配合割合で各成分を配合し、粉末状の一剤型皮膚外用剤とした。この一剤型皮膚外用剤粉を容器にとり、粉１に対し、重量比で５の水を加えて攪拌したところ、泡状のパック化粧料が得られた。
<Example 12>
Each component was mix | blended with the mixture ratio of Table 11, and it was set as the powdery one-part skin external preparation. When this one-part type skin external preparation powder was put in a container and 5 weight-percent water was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.
＜実施例１３＞
表１２記載の配合割合で各成分を配合し、粉末状の一剤型皮膚外用剤とした。この一剤型皮膚外用剤粉を容器にとり、粉１に対し、重量比で３の水を加えて攪拌したところ、泡状のパック化粧料が得られた。
<Example 13>
Each component was mix | blended with the mixture ratio of Table 12, and it was set as the powdery one-part type skin external preparation. When this one-part type skin external preparation powder was put in a container, and water of 3 by weight was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.
＜実施例１４＞
表１３記載の配合割合で各成分を配合し、粉末状の一剤型皮膚外用剤とした。この一剤型皮膚外用剤粉を容器にとり、粉１に対し、重量比で３の水を加えて攪拌したところ、泡状のパック化粧料が得られた。
<Example 14>
Each component was mix | blended with the mixture ratio of Table 13, and it was set as the powdery one-part type skin external preparation. When this one-part type skin external preparation powder was put in a container, and water of 3 by weight was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.
＜実施例１５＞
表１４記載の配合割合で各成分を配合し、粉末状の一剤型皮膚外用剤とした。この一剤型皮膚外用剤粉を容器にとり、粉１に対し、重量比で３の水を加えて攪拌したところ、泡状のパック化粧料が得られた。
<Example 15>
Each component was mix | blended with the mixture ratio of Table 14, and it was set as the powdery one-part type skin external preparation. When this one-part type skin external preparation powder was put in a container, and water of 3 by weight was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.
＜実施例１６＞
表１５記載の配合割合で各成分を配合し、粉末状の一剤型皮膚外用剤とした。この一剤型皮膚外用剤粉を容器にとり、粉１に対し、重量比で１の水を加えて攪拌したところ、泡状のパック化粧料が得られた。
<Example 16>
Each component was mix | blended with the mixture ratio of Table 15, and it was set as the powdery one-part type skin external preparation. When this one-part type skin external preparation powder was placed in a container and 1 weight of water was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.
＜実施例１７＞
表１６記載の配合割合で各成分を配合し、粉末状の一剤型皮膚外用剤とした。この一剤型皮膚外用剤粉を容器にとり、粉１に対し、重量比で１０の水を加えて攪拌したところ、泡状のパック化粧料が得られた。
<Example 17>
Each component was mix | blended with the compounding ratio of Table 16, and it was set as the powdery one-part skin external preparation. When this one-part type skin external preparation powder was placed in a container and 10 weight-percent water was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.
＜実施例１８＞
表１７記載の配合割合で各成分を配合し、粉末状の一剤型皮膚外用剤とした。この一剤型皮膚外用剤粉を容器にとり、粉１に対し、重量比で５の水を加えて攪拌したところ、泡状のパック化粧料が得られた。
<Example 18>
Each component was mix | blended with the mixture ratio of Table 17, and it was set as the powdery one-part type skin external preparation. When this one-part type skin external preparation powder was put in a container and 5 weight-percent water was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.
＜実施例１９＞
表１８記載の配合割合で各成分を配合し、粉末状の一剤型皮膚外用剤とした。この一剤型皮膚外用剤粉を容器にとり、粉１に対し、重量比で３の水を加えて攪拌したところ、泡状のパック化粧料が得られた。
<Example 19>
Each component was mix | blended with the mixture ratio of Table 18, and it was set as the powdery one-part type skin external preparation. When this one-part type skin external preparation powder was put in a container, and water of 3 by weight was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.
上記処方による一剤型皮膚外用剤は、いずれも水への良好な溶解性を示し、それぞれ炭酸ガス発生によるきめ細かな泡を発生した。各処方による一剤型皮膚外用剤から得られる泡状のパック化粧料を顔面に塗布した場合、数分間の間、垂れ落ち等がなく、血行促進作用が持続して得られた。特に、一剤型皮膚外用剤に対し１０倍量の水を加えた実施例９及び１７の処方であっても、垂れ落ち等はみられず、パックとして良好に機能することが確認できた。 All of the one-part skin external preparations according to the above formulations showed good solubility in water, and each produced fine bubbles due to the generation of carbon dioxide. When the foam-like pack cosmetic obtained from the one-pack type external preparation for each formulation was applied to the face, there was no dripping or the like for several minutes, and the blood circulation promoting action was continuously obtained. In particular, even in the formulations of Examples 9 and 17 in which 10 times the amount of water was added to the one-pack type external skin preparation, no dripping or the like was observed, and it was confirmed that it functions well as a pack.
Claims (2)
The one-part skin external preparation according to claim 1, wherein the hydrophilic protein compound is at least one selected from casein, collagen, gelatin, albumin, fibroin, elastin, keratin, and sericin.
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| CN111212651A (en) * | 2017-08-17 | 2020-05-29 | 田中雅也 | Carbon dioxide preparation for external use |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04217609A (en) * | 1990-12-19 | 1992-08-07 | Takashi Ishigaki | Foamable cosmetic and use thereof |
| JPH05229933A (en) * | 1992-02-21 | 1993-09-07 | Takashi Ishigaki | Foaming powdery cosmetic |
| JPH08268828A (en) * | 1995-03-31 | 1996-10-15 | Shiseido Co Ltd | Pack cosmetic |
| JP2000191429A (en) * | 1998-12-28 | 2000-07-11 | Kao Corp | Foamable cosmetic |
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| JP4099129B2 (en) * | 2003-09-17 | 2008-06-11 | 花王株式会社 | Carbon dioxide supply skin cosmetics |
| JP2005194233A (en) * | 2004-01-08 | 2005-07-21 | Kansai Koso Kk | Foaming skin cosmetic |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04217609A (en) * | 1990-12-19 | 1992-08-07 | Takashi Ishigaki | Foamable cosmetic and use thereof |
| JPH05229933A (en) * | 1992-02-21 | 1993-09-07 | Takashi Ishigaki | Foaming powdery cosmetic |
| JPH08268828A (en) * | 1995-03-31 | 1996-10-15 | Shiseido Co Ltd | Pack cosmetic |
| JP2000191429A (en) * | 1998-12-28 | 2000-07-11 | Kao Corp | Foamable cosmetic |
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| JP2014224084A (en) | 2014-12-04 |
| JP6142343B2 (en) | 2017-06-07 |
| JP5544671B1 (en) | 2014-07-09 |
| JP5681896B2 (en) | 2015-03-11 |
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