JP2014505733A5 - - Google Patents
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- JP2014505733A5 JP2014505733A5 JP2013554551A JP2013554551A JP2014505733A5 JP 2014505733 A5 JP2014505733 A5 JP 2014505733A5 JP 2013554551 A JP2013554551 A JP 2013554551A JP 2013554551 A JP2013554551 A JP 2013554551A JP 2014505733 A5 JP2014505733 A5 JP 2014505733A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- oxymetazoline
- composition according
- amount
- treating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- WYWIFABBXFUGLM-UHFFFAOYSA-N Oxymetazoline Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C)=C1CC1=NCCN1 WYWIFABBXFUGLM-UHFFFAOYSA-N 0.000 claims 12
- 229960001528 oxymetazoline Drugs 0.000 claims 12
- 206010043189 Telangiectasia Diseases 0.000 claims 3
- 208000009056 Telangiectasis Diseases 0.000 claims 3
- 230000002757 inflammatory Effects 0.000 claims 3
- 230000003902 lesions Effects 0.000 claims 3
- 231100001005 telangiectasia Toxicity 0.000 claims 3
- 206010015150 Erythema Diseases 0.000 claims 2
- 241001303601 Rosacea Species 0.000 claims 2
- 231100000321 erythema Toxicity 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- -1 pH adjusters Substances 0.000 claims 2
- 239000000546 pharmaceutic aid Substances 0.000 claims 2
- 201000004700 rosacea Diseases 0.000 claims 2
- 210000003491 Skin Anatomy 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive Effects 0.000 claims 1
- 230000000111 anti-oxidant Effects 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-M buffer Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 239000003974 emollient agent Substances 0.000 claims 1
- 239000003995 emulsifying agent Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000003605 opacifier Substances 0.000 claims 1
- 230000002335 preservative Effects 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 230000001225 therapeutic Effects 0.000 claims 1
- 239000004034 viscosity adjusting agent Substances 0.000 claims 1
Claims (17)
- オキシメタゾリンを含む、紅斑、毛細血管拡張症、または炎症性病変から選択される２つ以上の酒さの症状を治療するための医薬組成物。
- 医薬的に許容される賦形剤を更に含む、請求項１に記載の医薬組成物。
- 乳化剤、保存剤、乳化安定剤、ｐＨ調整剤、キレート化剤、粘度調整剤、抗酸化剤、界面活性剤、皮膚軟化剤、乳白剤、スキンコンディショナー、緩衝剤、およびそれらの組み合わせからなる群から選択される添加剤をさらに含む、請求項１又は２に記載の医薬組成物。
- 局所的に活性な薬剤または化粧剤をさらに含む、請求項１〜３のいずれか１項に記載の医薬組成物。
- 前記オキシメタゾリンは、０．００７５重量％〜５重量％の量である、請求項１〜４のいずれか１項に記載の医薬組成物。
- 前記オキシメタゾリンは、０．００７５重量％〜３重量％の量である、請求項１〜４のいずれか１項に記載の医薬組成物。
- オキシメタゾリンは、０．０１重量％〜２．５重量％の量である、請求項１〜４のいずれか１項に記載の医薬組成物。
- オキシメタゾリンは、０．０１％重量〜２重量％の量である、請求項１〜４のいずれか１項に記載の医薬組成物。
- オキシメタゾリンは、０．０１重量％〜１重量％の量である、請求項１〜４のいずれか１項に記載の医薬組成物。
- オキシメタゾリンは、０．０１重量％〜０．５重量％の量である、請求項１〜４のいずれか１項に記載の医薬組成物。
- オキシメタゾリンは、０．０１重量％〜０．２５重量％の量である、請求項１〜４のいずれか１項に記載の医薬組成物。
- オキシメタゾリンは、０．０１重量％〜０．１５重量％の量である、請求項１〜４のいずれか１項に記載の医薬組成物。
- 治療効果が、前記組成物の最後の投与から少なくとも３０日間にわたって維持される、請求項１〜１２のいずれか１項に記載の医薬組成物。
- オキシメタゾリンを含む、酒さに関連する紅斑、毛細血管拡張症、および炎症性病変からなる群から選択される状態を治療するための医薬組成物。
- オキシメタゾリンを含む、毛細血管拡張症を治療するための医薬組成物。
- オキシメタゾリンを含む、炎症性病変を治療するための医薬組成物。
- 医薬的に許容される賦形剤を更に含む、請求項１４〜１６のいずれか１項に記載の医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161443210P | 2011-02-15 | 2011-02-15 | |
| US61/443,210 | 2011-02-15 | ||
| PCT/US2012/025068 WO2012112566A1 (en) | 2011-02-15 | 2012-02-14 | Pharmaceutical cream compositions of oxymetazoline for treating symptoms of rosacea |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017002106A Division JP6389534B2 (ja) | 2011-02-15 | 2017-01-10 | 酒さの症状を治療するためのオキシメタゾリンの薬学的クリーム組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014505733A JP2014505733A (ja) | 2014-03-06 |
| JP2014505733A5 true JP2014505733A5 (ja) | 2015-04-09 |
| JP6225030B2 JP6225030B2 (ja) | 2017-11-01 |
Family
ID=45757218
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013554551A Active JP6225030B2 (ja) | 2011-02-15 | 2012-02-14 | 酒さの症状を治療するためのオキシメタゾリンの薬学的クリーム組成物 |
| JP2017002106A Active JP6389534B2 (ja) | 2011-02-15 | 2017-01-10 | 酒さの症状を治療するためのオキシメタゾリンの薬学的クリーム組成物 |
| JP2018153450A Abandoned JP2018193399A (ja) | 2011-02-15 | 2018-08-17 | 酒さの症状を治療するためのオキシメタゾリンの薬学的クリーム組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017002106A Active JP6389534B2 (ja) | 2011-02-15 | 2017-01-10 | 酒さの症状を治療するためのオキシメタゾリンの薬学的クリーム組成物 |
| JP2018153450A Abandoned JP2018193399A (ja) | 2011-02-15 | 2018-08-17 | 酒さの症状を治療するためのオキシメタゾリンの薬学的クリーム組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US20120208858A1 (ja) |
| EP (2) | EP3578178A1 (ja) |
| JP (3) | JP6225030B2 (ja) |
| KR (2) | KR102058756B1 (ja) |
| CN (2) | CN103458897A (ja) |
| AU (3) | AU2012217858A1 (ja) |
| BR (1) | BR112013020770A2 (ja) |
| CA (1) | CA2827373C (ja) |
| ES (1) | ES2742273T3 (ja) |
| RU (1) | RU2648439C2 (ja) |
| WO (1) | WO2012112566A1 (ja) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9486408B2 (en) | 2005-12-01 | 2016-11-08 | University Of Massachusetts Lowell | Botulinum nanoemulsions |
| MX2007009796A (es) | 2007-08-14 | 2009-02-25 | Cell Therapy And Technology S | Gel conteniendo pirfenidona. |
| KR102058756B1 (ko) | 2011-02-15 | 2020-01-22 | 어클라리스 쎄라퓨틱스, 인코포레이티드 | 주사비 징후들의 치료용 옥시메타졸린의 약학 크림 조성물들 |
| US20120225918A1 (en) * | 2011-03-03 | 2012-09-06 | Voom, Llc | Compositions and Methods for Non-Surgical Treatment of Ptosis |
| PT2739266T (pt) * | 2011-08-04 | 2016-10-04 | Omeros Corp | Soluções anti-inflamatórias estáveis para injecção |
| WO2013041967A2 (en) | 2011-09-20 | 2013-03-28 | Altavista Instituto De Investigation Medica S.A.S | Compositions and methods for treating presbyopia, mild hyperopia, and irregular astigmatism |
| MX346763B (es) | 2012-03-28 | 2017-03-31 | Cell Therapy And Tech S A De C V | Composición tópica semisólida conteniendo pirfenidona y dialil óxido de disulfuro modificado (odd-m) para eliminar o prevenir el acné. |
| FR3000395A1 (fr) * | 2012-12-31 | 2014-07-04 | Galderma Res & Dev | Combinaison de laropiprant et d'oxymetazoline pour le traitement de la rosacee |
| US9795560B2 (en) | 2013-02-01 | 2017-10-24 | Ocularis Pharma, Llc | Aqueous ophthalmic solutions of phentolamine and medical uses thereof |
| WO2014121028A1 (en) | 2013-02-01 | 2014-08-07 | Ocularis Pharma, Llc | Methods and compositions for daily ophthalmic administration of phentolamine to improve visual performance |
| EP3062888A1 (en) * | 2013-10-28 | 2016-09-07 | Cipher Pharmaceuticals | Compositions for dermatological use |
| AU2015252947B2 (en) * | 2014-05-01 | 2020-07-09 | Anterios, Inc. | Demonstrable efficacy across or within patient populations |
| CA2951725C (en) | 2014-06-11 | 2022-06-07 | Allergan, Inc. | Stabilized oxymetazoline formulations and their uses |
| CA2997284A1 (en) * | 2015-09-17 | 2017-03-23 | June Jacobs Laboratories, Llc | Compositions and methods for the treatment and prevention of radiation dermatitis |
| WO2018000067A1 (pt) * | 2016-06-28 | 2018-01-04 | Doris Maria Hexsel | Uso de uma substância ativa no tratamento do melasma telangiectásico |
| MX2019005833A (es) | 2016-11-21 | 2019-10-30 | Eirion Therapeutics Inc | Administracion transdermica de agentes grandes. |
| EA202090763A1 (ru) * | 2017-11-15 | 2020-08-03 | Борис Славинович ФАРБЕР | Фармацевтическая композиция для стимуляции деления стволовых клеток и подавления вирулентности бактерий |
| MX368750B (es) * | 2018-08-31 | 2019-10-15 | Cell Therapy And Tech S A De C V | Composiciones farmaceuticas semisolidas de base oleosa conteniendo pirfenidona para su aplicacion en la reparacion tisular. |
| KR20210096096A (ko) | 2018-10-26 | 2021-08-04 | 오큐파이어 파마, 인크. | 노안, 산동, 및 기타 안구 장애의 치료를 위한 방법 및 조성물 |
| US20220033360A1 (en) * | 2018-11-26 | 2022-02-03 | Cellix Bio Private Limited | Ophthalmic compositions and methods for the treatment of skin diseases and eye diseases |
| JP2022531154A (ja) * | 2019-04-30 | 2022-07-06 | ジェネロス バイオファーマ リミテッド | 炎症により引き起こされる自己免疫性皮膚疾患を治療するための化合物及びその使用 |
| CN115368310A (zh) | 2021-05-18 | 2022-11-22 | 奥库菲尔医药公司 | 合成甲磺酸酚妥拉明的方法 |
| KR102633256B1 (ko) * | 2021-10-08 | 2024-02-05 | (주)우리스마트바이오 | 참당귀 추출물을 이용한 피부개선용 화장품 조성물, 이를 포함한 피부개선용 화장품 및 피부개선용 화장품 제조방법 |
| WO2023133199A1 (en) * | 2022-01-05 | 2023-07-13 | Asymmetric Therapeutics, Llc | Methods and compositions for treatment of cutaneous proliferative disorders and other skin conditions |
| WO2023249992A2 (en) * | 2022-06-21 | 2023-12-28 | Jjr&D, Llc | Topical benzimidazole formulations and methods for use in treating inflammatory dermatoses |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3147275A (en) | 1964-09-01 | Nh-cha | ||
| US8093293B2 (en) * | 1998-07-06 | 2012-01-10 | Johnson & Johnson Consumer Companies, Inc. | Methods for treating skin conditions |
| US6433024B1 (en) | 2000-05-08 | 2002-08-13 | Karl F. Popp | Topical anti-acne composition |
| US7395211B2 (en) | 2000-08-16 | 2008-07-01 | Dolby Laboratories Licensing Corporation | Modulating one or more parameters of an audio or video perceptual coding system in response to supplemental information |
| US6479060B1 (en) * | 2001-09-04 | 2002-11-12 | Healthpoint, Ltd. | Elegant hydrogenated castor oil ointments |
| US6824786B2 (en) | 2001-11-27 | 2004-11-30 | Ruey J. Yu | Compositions comprising phenyl-glycine derivatives |
| US6573301B1 (en) | 2002-04-23 | 2003-06-03 | Bradley Pharmaceuticals, Inc. | Carbamide peroxide compositions for the treatment of dermatological disorders and methods for their use |
| US7439241B2 (en) * | 2003-05-27 | 2008-10-21 | Galderma Laboratories, Inc. | Compounds, formulations, and methods for treating or preventing rosacea |
| US7812049B2 (en) * | 2004-01-22 | 2010-10-12 | Vicept Therapeutics, Inc. | Method and therapeutic/cosmetic topical compositions for the treatment of rosacea and skin erythema using α1-adrenoceptor agonists |
| PL1761266T3 (pl) * | 2004-05-25 | 2013-09-30 | Galderma Pharma Sa | Związki, preparaty i sposoby leczenia lub zapobiegania procesom zapalnym skóry |
| CN101166535A (zh) | 2005-03-15 | 2008-04-23 | 坎皮纳荷兰控股有限责任公司 | 乳蛋白的皮肤病学应用 |
| CA2600384C (en) * | 2005-03-30 | 2016-08-30 | Revance Therapeutics, Inc. | Compositions and methods for treating acne |
| WO2007000192A1 (en) | 2005-06-29 | 2007-01-04 | Dsm Ip Assets B.V. | Topical compositions comprising nanoparticles of an isoflavone |
| CA2644311C (en) * | 2006-03-01 | 2012-07-10 | Tristrata, Inc. | Composition and method for topical treatment of tar-responsive dermatological disorders |
| US20080031979A1 (en) * | 2006-08-04 | 2008-02-07 | Claude Saliou | Use of extracts for the treatment of viral disorders |
| RU2310439C1 (ru) * | 2006-10-05 | 2007-11-20 | Закрытое акционерное общество Фармацевтическое научно-производственное предприятие "Ретиноиды" (ЗАО "Ретиноиды") | Мазевая акарицидная композиция и способ лечения демодекоза и сопутствующих ему заболеваний |
| US9511016B2 (en) * | 2007-06-12 | 2016-12-06 | Epicentrx, Inc. | Topical composition for treating pain |
| US20090061020A1 (en) | 2007-08-31 | 2009-03-05 | Theobald Klaus P | Brimonidine Compositions for Treating Erythema |
| HUE042931T2 (hu) | 2007-11-16 | 2019-07-29 | Aclaris Therapeutics Inc | Kompozíciók és eljárások purpura kezelésére |
| US20090130029A1 (en) * | 2007-11-21 | 2009-05-21 | Foamix Ltd. | Glycerol ethers vehicle and pharmaceutical compositions thereof |
| BR112012009891A2 (pt) | 2009-10-26 | 2015-09-29 | Galderma Pharma Sa | métodos para tratar eritema agudo e para prevenir o eritema agudo e uma inflamação secundária em um humano em necessidade do mesmo |
| US20120082625A1 (en) | 2010-09-28 | 2012-04-05 | Michael Graeber | Combination treatment for rosacea |
| JP6030067B2 (ja) * | 2010-12-03 | 2016-11-24 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | 薬学的クリーム組成物および使用法 |
| KR102058756B1 (ko) | 2011-02-15 | 2020-01-22 | 어클라리스 쎄라퓨틱스, 인코포레이티드 | 주사비 징후들의 치료용 옥시메타졸린의 약학 크림 조성물들 |
| JP2014523908A (ja) | 2011-07-14 | 2014-09-18 | アラーガン インコーポレイテッド | オキシメタゾリンのゲル組成物および使用方法 |
-
2012
- 2012-02-14 KR KR1020137024232A patent/KR102058756B1/ko active IP Right Grant
- 2012-02-14 ES ES12705755T patent/ES2742273T3/es active Active
- 2012-02-14 WO PCT/US2012/025068 patent/WO2012112566A1/en active Application Filing
- 2012-02-14 CN CN2012800179627A patent/CN103458897A/zh active Pending
- 2012-02-14 CN CN201710280045.2A patent/CN107007546A/zh active Pending
- 2012-02-14 US US13/396,165 patent/US20120208858A1/en not_active Abandoned
- 2012-02-14 AU AU2012217858A patent/AU2012217858A1/en not_active Abandoned
- 2012-02-14 BR BR112013020770A patent/BR112013020770A2/pt not_active Application Discontinuation
- 2012-02-14 EP EP19170085.5A patent/EP3578178A1/en active Pending
- 2012-02-14 KR KR1020197028285A patent/KR20190114010A/ko not_active Application Discontinuation
- 2012-02-14 EP EP12705755.2A patent/EP2675449B1/en active Active
- 2012-02-14 JP JP2013554551A patent/JP6225030B2/ja active Active
- 2012-02-14 CA CA2827373A patent/CA2827373C/en active Active
- 2012-02-14 RU RU2013141845A patent/RU2648439C2/ru active
-
2013
- 2013-12-30 US US14/144,106 patent/US20140113947A1/en not_active Abandoned
-
2017
- 2017-01-10 JP JP2017002106A patent/JP6389534B2/ja active Active
- 2017-04-26 AU AU2017202726A patent/AU2017202726B2/en active Active
-
2018
- 2018-08-17 JP JP2018153450A patent/JP2018193399A/ja not_active Abandoned
-
2019
- 2019-02-05 US US16/267,590 patent/US20190167566A1/en not_active Abandoned
- 2019-06-07 AU AU2019203993A patent/AU2019203993B2/en active Active
- 2019-11-04 US US16/673,549 patent/US11541000B2/en active Active
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