JP2014024338A - Apparatus for manufacturing acicular structure - Google Patents
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Abstract
Description
本発明は、皮膚の特定層に薬剤を注入する冶具として用いる針状構造物の製造方法に関するものである。 The present invention relates to a method for manufacturing a needle-like structure used as a jig for injecting a drug into a specific layer of skin.
人の皮膚は、表面から表皮、真皮及び皮下脂肪の３層に大きく分けられる。表皮は、掌や踵を除くとその厚さは平均１００μｍ前後であり、１ｍｍ２当たり５００〜６００個のランゲルハンス細胞を有している。ランゲルハンス細胞は、皮膚に侵入した抗原を取り込んで活性化するとともに、リンパ節に移動し、Ｔ細胞を刺激して細胞障害性細胞に分化させ、Ｔ細胞を介してＢ細胞を刺激することにより抗体を産出する。この作用から、ランゲルハンス細胞は、生体を感染や癌等から防御する役割を担っていると言える。 Human skin is roughly divided into three layers from the surface: epidermis, dermis and subcutaneous fat. The thickness of the epidermis is about 100 μm on average excluding palms and wrinkles, and has 500 to 600 Langerhans cells per mm 2. Langerhans cells take in and activate antigens that have entered the skin, move to lymph nodes, stimulate T cells to differentiate into cytotoxic cells, and stimulate B cells via T cells Is produced. From this action, it can be said that the Langerhans cells have a role of protecting the living body from infection and cancer.
ワクチンや薬物を表皮のランゲルハンス細胞に到達させる手段として、従来から注射針による投与が行われてきたが、注射針では針先が真皮まで到達してしまうとランゲルハンス細胞に効率的に取り込まれないという不具合や、患者にとっては痛みが伴うとともに、出血や２次感染の危険性がある。 As a means to make vaccines and drugs reach the Langerhans cells of the epidermis, administration with an injection needle has been performed conventionally, but if the needle tip reaches the dermis with an injection needle, it will not be efficiently taken up by Langerhans cells There are defects and pain for the patient, and there is a risk of bleeding and secondary infection.
そこで、注射針に替わり、基材上に複数の針状構造物を形成した上で、針先に薬物を塗布し、針を皮膚の表皮まで穿刺して薬物を注入する技術の開発がなされている（特許文献１〜４）。 Therefore, instead of an injection needle, a technology has been developed in which a plurality of needle-like structures are formed on a base material, a drug is applied to the needle tip, and the needle is punctured to the epidermis of the skin to inject the drug. (Patent Documents 1 to 4).
従来、針状構造物の製造方法としては、予め融解してある樹脂材に所望の凹凸形状を有するスタンパーを当接しつつ、加圧して成形するナノインプリント法（特許文献１）、あるいは特許文献２から４に記載されているような、融解した樹脂材を所望の立体形状を有する型枠に注入して成形固化する射出成形法による製造が主たるものである。 Conventionally, as a method for producing a needle-like structure, a nanoimprint method (Patent Document 1), in which a stamper having a desired uneven shape is brought into contact with a previously melted resin material and pressed, or Patent Document 2 is used. 4 is mainly produced by an injection molding method in which a molten resin material is injected into a mold having a desired three-dimensional shape and molded and solidified.
さらに、特許文献１では、アスペクト比の高い凸形状を得るために、光硬化性の樹脂を使用して所望の高さとなるまで、樹脂の注入と硬化を繰り返し行っている。また、特許文献２から４によると、凸形状アレイを射出成形で成形した後、基材シートと重ね合わせる構成として型枠と樹脂材の剥離を容易にしている。いずれにしても、装置としては、射出成形用の装置もしくは類似の装置が必要となり、装置、工程ともに大掛かりな構成となるという問題がある。 Further, in Patent Document 1, in order to obtain a convex shape with a high aspect ratio, the resin is injected and cured repeatedly until a desired height is obtained using a photocurable resin. Further, according to Patent Documents 2 to 4, after the convex array is formed by injection molding, the mold frame and the resin material are easily peeled as a configuration in which the convex array is superimposed on the base sheet. In any case, an apparatus for injection molding or a similar apparatus is required as an apparatus, and there is a problem that both the apparatus and the process have a large structure.
針状構造物を組成する材料としては、体内に残存しても安心な生分解性の樹脂が望ましい。しかしながら、射出成形法は成形型に樹脂材を注入するため、予め樹脂材をある温度域で加熱待機させておく必要がある。そのため、熱の影響を受けて分解しやすい生分解性樹脂には適していない。 The material constituting the needle-like structure is preferably a biodegradable resin that is safe even if it remains in the body. However, since the injection molding method injects the resin material into the mold, it is necessary to wait for the resin material to be heated in a certain temperature range in advance. Therefore, it is not suitable for a biodegradable resin that is easily decomposed under the influence of heat.
そこで、生分解性樹脂からなるアスペクト比の高い針状構造物を製造する方法としては、底面に針状の凹部を形成した転写版上に、生分解性樹脂材を積載して適度な温度に保持して軟化させた後、所定時間プレスして針状の凹部に生分解性樹脂を浸透させ、その後徐冷し剥離する方法が有望である。ところが、この方法の単純な適用では、軟化した生分解性樹脂を転写版の針状凹部の先端部まで樹脂を到達させることが出来ず、針状構造物としての所定の形状を得ることが難しいという問題があった。
そこで、本発明は、上記の方法において、転写版に形成された針状凹部の最先端部末端まで樹脂を到達させる手段の提供を目的とした。
Therefore, as a method of manufacturing a needle-shaped structure having a high aspect ratio made of a biodegradable resin, a biodegradable resin material is loaded on a transfer plate having a needle-like recess formed on the bottom surface and kept at an appropriate temperature. After holding and softening, a method of pressing for a predetermined time to allow the biodegradable resin to permeate into the needle-like concave portion, and then gradually cooling and peeling off is promising. However, with a simple application of this method, the softened biodegradable resin cannot reach the tip of the needle-like concave portion of the transfer plate, and it is difficult to obtain a predetermined shape as a needle-like structure. There was a problem.
Therefore, the present invention has an object of providing means for causing the resin to reach the end of the most distal portion of the needle-like recess formed in the transfer plate in the above method.
本発明の請求項１に記載の発明は、皮膚の特定層に薬物を注入する治具として用いられ、基材の片面に複数の微小針が形成されている針状構造物の製造装置であって、前記針状構造物の前記微小針形状を転写した転写版と、前記転写版上の樹脂材を加熱融解する樹脂材加熱手段と、前記融解した樹脂材をプレスして前記転写版の針形状部位に埋設して成形するプレス手段と、前記成形された樹脂材を冷却硬化させる冷却手段と、を有し、前記プレス手段が針状構造物の外形を形作る成形枠と、前記成形枠の内部に配置されるパンチを備えることを特徴とする針状構造物の製造装置としたものである。 The invention according to claim 1 of the present invention is an apparatus for producing a needle-like structure that is used as a jig for injecting a drug into a specific layer of skin and has a plurality of microneedles formed on one side of a substrate. A transfer plate on which the fine needle shape of the needle-like structure is transferred, a resin material heating means for heating and melting the resin material on the transfer plate, and the needle of the transfer plate by pressing the melted resin material A pressing means for embedding in a shape part and molding; and a cooling means for cooling and curing the molded resin material, the molding means forming the outer shape of the needle-like structure, and the molding frame The present invention provides an apparatus for manufacturing a needle-like structure comprising a punch disposed inside.
また本発明の請求項２に記載の発明は、前記成形枠と前記パンチが、各々上下動可能であることを特徴とする請求項１記載の針状構造物の製造装置としたものである。 The invention according to claim 2 of the present invention is the needle-shaped structure manufacturing apparatus according to claim 1, wherein the forming frame and the punch are each movable up and down.
また本発明の請求項３に記載の発明は、前記成形枠と前記パンチが、各々エアシリンダに接続されていることを特徴とする請求項１または請求項２記載の針状構造物の製造装置としたものである。 The invention according to claim 3 of the present invention is characterized in that the forming frame and the punch are each connected to an air cylinder, the needle-like structure manufacturing apparatus according to claim 1 or 2. It is what.
また本発明の請求項４に記載の発明は、さらに、前記転写版から前記成形された針状構造物を剥離するための把持手段を備える、請求項１乃至３のいずれかに記載の針状構造物の製造装置としたものである。 The invention according to claim 4 of the present invention further comprises a gripping means for peeling the molded needle-like structure from the transfer plate. This is a structure manufacturing apparatus.
本発明によれば、複数回のプレス工程と再加熱再融解工程を設けることにより、転写版に形成した針形状凹部に樹脂材を行き渡らせることが可能で、特に、製造工程１サイクルで針状構造物１個分の分量である極少量の樹脂量で微細な形状の成形が可能である。 According to the present invention, by providing a plurality of pressing steps and reheating and remelting steps, it is possible to distribute the resin material to the needle-shaped concave portions formed on the transfer plate, and in particular, the needle shape in one cycle of the manufacturing process. It is possible to form a fine shape with a very small amount of resin, which is equivalent to one structure.
さらに、本発明の成形装置においては、射出成形装置では必要とされる、樹脂材を所定の温度域で加熱（溶融）待機させておくための装置が不必要である。また、プレス工程で必要なプレス圧力もそれほど大きくしなくても成形が可能であるため、大出力のプレス手段を必要としない。従って本発明の成形装置は、設備が大掛かりでなく、設置スペースも縮小できるという長所がある。 Further, the molding apparatus of the present invention does not require an apparatus for heating (melting) the resin material in a predetermined temperature range, which is required in the injection molding apparatus. Further, since molding can be performed without increasing the pressing pressure required in the pressing process, a high-output pressing means is not required. Therefore, the molding apparatus of the present invention has advantages in that the equipment is not large and the installation space can be reduced.
以下、本発明になる針状構造物の製造方法の一例を、図面に基づいて説明する。 Hereinafter, an example of the manufacturing method of the acicular structure which becomes this invention is demonstrated based on drawing.
図１は本発明の成形装置の構成を説明する概略図であって、（ａ）は成形装置を正面から見た概略図、（ｂ）は成形装置を側面から見た概略図である。１〜４はエアシリンダ、５は成形枠、６はパンチ、７はヒーター、８は冷却ノズルである。図２は本発明の針状構造物成形のプロセス工程図である。図３（ｃ）〜（ｋ）は、本発明の成形にかかる一連の流れを示した工程図である。尚、９は転写版、１０は樹脂材である。 1A and 1B are schematic diagrams for explaining the configuration of the molding apparatus of the present invention. FIG. 1A is a schematic view of the molding apparatus viewed from the front, and FIG. 1B is a schematic view of the molding apparatus viewed from the side. 1 to 4 are air cylinders, 5 is a forming frame, 6 is a punch, 7 is a heater, and 8 is a cooling nozzle. FIG. 2 is a process step diagram for forming a needle-like structure according to the present invention. 3 (c) to 3 (k) are process diagrams showing a series of flows according to the molding of the present invention. In addition, 9 is a transfer plate and 10 is a resin material.
本発明の成形装置では、図１に示すように、成形枠５とパンチ６の上方にエアシリンダ１及びエアシリンダ２を備え、成形枠５とパンチ６が各々上下動できるようになっている。また、その下方には、エアシリンダ３によって加熱体であるヒーター７が上下動できるよう設置されている。 In the molding apparatus of the present invention, as shown in FIG. 1, an air cylinder 1 and an air cylinder 2 are provided above the molding frame 5 and the punch 6 so that the molding frame 5 and the punch 6 can move up and down. In addition, a heater 7 that is a heating body is installed below the air cylinder 3 so as to move up and down.
図２は図１の成形装置を用いて針状構造物を樹脂から成形するプロセスの工程を示し、図３（ｃ）〜（ｋ）により、樹脂の成形工程にかかる流れを図で示している。 FIG. 2 shows a process of molding a needle-like structure from a resin using the molding apparatus of FIG. 1, and FIGS. 3 (c) to 3 (k) show a flow of the resin molding process. .
ステップＳ１では、図３（ｃ）に示すように、転写版９上に固形状、または粒状の樹脂材１０を積載した後、ステップＳ２の加熱工程に入る。加熱工程では、エアシリンダ３によってヒーター７が転写版９の下面に接触し、１回目の加熱を開始する。その後、樹脂材の融解温度に達すると樹脂材１０の融解が始まり、図３（ｄ）に示すように樹脂材１０が膨張し始める。 In step S1, as shown in FIG. 3C, after the solid or granular resin material 10 is loaded on the transfer plate 9, the heating process of step S2 is started. In the heating step, the heater 7 comes into contact with the lower surface of the transfer plate 9 by the air cylinder 3, and the first heating is started. Thereafter, when the melting temperature of the resin material is reached, the resin material 10 starts to melt and the resin material 10 starts to expand as shown in FIG.
樹脂材１０全体が融解したところで、図３（ｄ）に示すように、まず針状構造物の外形を形作る成形枠５を転写版９上に降下させる。その後、ステップＳ３として、時間をおかずに図３（ｅ）に示すようにパンチ６で融解した樹脂材１０をプレスする。この１回目のプレスは、転写版９の針状構造物用凹部が形成された最外の周辺部まで樹脂材１０を行き渡らせるための予備的なプレスである。このときパンチ６が樹脂材１０に接触する時間は１秒以上である。ただし、樹脂材１０として使用される樹脂の種類によっては、所定時間以上の高温状態が続くと分解や硬化が起きてしまうものもあるので、パンチ６が樹脂材１０に接触している時間は樹脂材１０の材質を考慮した上でなるべく短時間とすることが望ましい。 When the entire resin material 10 is melted, as shown in FIG. 3 (d), first, the molding frame 5 that forms the outer shape of the needle-like structure is lowered onto the transfer plate 9. Thereafter, as step S3, the resin material 10 melted by the punch 6 is pressed as shown in FIG. This first press is a preliminary press for spreading the resin material 10 to the outermost peripheral portion where the concave portion for the needle-like structure of the transfer plate 9 is formed. At this time, the time for which the punch 6 contacts the resin material 10 is 1 second or more. However, depending on the type of resin used as the resin material 10, decomposition and curing may occur when a high temperature state continues for a predetermined time or longer, so the time during which the punch 6 is in contact with the resin material 10 is a resin. It is desirable to make the time as short as possible in consideration of the material of the material 10.
１回目のプレスが終わった後、図３（ｆ）に示すように成形枠５及びパンチ６は上方へと移動し、ステップＳ４の２回目の加熱を行い、ステップＳ３で一度硬化した樹脂材１０を再度融解する。 After the first press, the molding frame 5 and the punch 6 are moved upward as shown in FIG. 3 (f), the second heating in Step S4 is performed, and the resin material 10 once cured in Step S3. Thaw again.
樹脂材１０が再融解したところで、図３（ｇ）に示すように成形枠５が転写版９上に降下させる。その後、ステップＳ５として、時間をおかずに図３（ｈ）に示すようにパンチ６で融解した樹脂材１０を再プレスする。この２回目のプレスは、樹脂を針状凹部の最先端部まで押し込んで針状構造物の最終形状を形成させるためのものである。 When the resin material 10 is remelted, the molding frame 5 is lowered onto the transfer plate 9 as shown in FIG. Thereafter, as step S5, the resin material 10 melted by the punch 6 is re-pressed as shown in FIG. This second press is for pushing the resin to the most distal end of the needle-like recess to form the final shape of the needle-like structure.
ステップＳ６では、ヒーター７による加熱が終了し、エアシリンダ４によってヒーター７と冷却ノズル８が入れ替わる工程となる。 In step S <b> 6, the heating by the heater 7 is finished, and the heater 7 and the cooling nozzle 8 are switched by the air cylinder 4.
ステップＳ７の冷却工程では、図３（ｉ）に示すとおり、冷却ノズル８よりエアが吐出され、転写版９の下面より樹脂材１０を冷却、硬化させる。このとき、樹脂材１０の凝固点を下回る温度まで冷却を行う。 In the cooling step of step S7, as shown in FIG. 3I, air is discharged from the cooling nozzle 8, and the resin material 10 is cooled and cured from the lower surface of the transfer plate 9. At this time, cooling is performed to a temperature below the freezing point of the resin material 10.
最後にステップＳ８として、硬化した樹脂と転写版の離型の工程となる。まず、図３（ｊ）に示すように、十分に冷却され凝固した樹脂材１０の外形を形作った成形枠５を、針状構造物の厚さ以上の高へと上げて外形部を分離する。その後、パンチ６も樹脂材１０から上昇させ、成形済みの樹脂材１０のみが転写版９上へ残ることになる。そして最終的に、ピンセットや把持機能を備えたジグ等で、転写版９から成形済みの樹脂材１０を離型することで、微小針を備えた針状構造物を得ることが可能である。 Finally, step S8 is a step of releasing the cured resin and the transfer plate. First, as shown in FIG. 3 (j), the molding frame 5 that forms the outer shape of the sufficiently cooled and solidified resin material 10 is raised to a height higher than the thickness of the needle-like structure to separate the outer portion. . Thereafter, the punch 6 is also raised from the resin material 10, and only the molded resin material 10 remains on the transfer plate 9. Finally, by removing the molded resin material 10 from the transfer plate 9 with a jig or the like having tweezers or a gripping function, it is possible to obtain a needle-like structure having microneedles.
また、本明細書では、ヒーターと冷却ノズルの駆動をエアシリンダとしているが、それにとらわれることなく、モーター等の駆動であっても構わない。 In this specification, the heater and the cooling nozzle are driven by an air cylinder. However, the motor and the like may be driven without being limited thereto.
本実施の形態における実施例を下記に示す。 Examples of the present embodiment are shown below.
針状構造物の微小針の形状を反転した形状の針状凹部が形成されている転写版９上に、固形状の樹脂材１０を積載する。次に、転写版９の下方に設置されているヒーター７を、転写版９の下面に接触させ、転写版９の温度を上げて樹脂材１０の融解を行う。 A solid resin material 10 is loaded on a transfer plate 9 in which a needle-like concave portion having a shape obtained by inverting the shape of a microneedle of a needle-like structure is formed. Next, the heater 7 installed below the transfer plate 9 is brought into contact with the lower surface of the transfer plate 9, and the temperature of the transfer plate 9 is raised to melt the resin material 10.
樹脂材１０が全体的に融解したところで、転写版９の外周部まで樹脂材１０を行き渡らせるためにパンチ６により１回目のプレスを行う。このときのプレス時間は１秒程度で構わない。 When the resin material 10 is melted as a whole, a first press is performed by the punch 6 in order to spread the resin material 10 to the outer peripheral portion of the transfer plate 9. The pressing time at this time may be about 1 second.
１回目のプレス工程で融解した樹脂材１０がパンチ６に熱を奪われ、表面が凝固するため、再加熱を行い樹脂材１０を再融解させる。再度、樹脂材１０が融解したところで、成形枠５とパンチ６にて２回目のプレスを行う。２回目のプレスは、樹脂を針状凹部の先端部まで完全に到達させ、針状構造物の微小針の外形形状を整えるためのプレスである。 Since the resin material 10 melted in the first pressing step is deprived of heat by the punch 6 and the surface is solidified, the resin material 10 is remelted by reheating. When the resin material 10 is melted again, a second press is performed with the molding frame 5 and the punch 6. The second press is a press for adjusting the outer shape of the fine needle of the needle-like structure by causing the resin to completely reach the tip of the needle-like recess.
形状形成のための所定時間が経過した後、ヒーター７を転写版９から離し、代わりに冷却ノズル８からエアを吐出し、転写版９の下面から樹脂材１０を冷却し、樹脂材を凝固させる。このときの時間は、樹脂材が凝固温度以下に下がるまで行うものとする。 After a predetermined time for forming the shape has elapsed, the heater 7 is separated from the transfer plate 9 and air is discharged from the cooling nozzle 8 instead, and the resin material 10 is cooled from the lower surface of the transfer plate 9 to solidify the resin material. . The time at this time shall be performed until the resin material falls below the solidification temperature.
樹脂材１０が凝固した後、成形枠５とパンチ６を樹脂材１０から離し、針状構造物の成形工程が終了する。例えば、ピンセット等のジグを用いて転写版９と樹脂材１０を離型させる。 After the resin material 10 is solidified, the molding frame 5 and the punch 6 are separated from the resin material 10 and the molding process of the needle-like structure is completed. For example, the transfer plate 9 and the resin material 10 are released using a jig such as tweezers.
以上のような製造工程により、図４に示したような、平板状の基材１１の片面に複数の微小針１２が形成されている針状構造物を得ることが出来る。図４では平板状の基材１１は矩形状の場合を示しているが、他の形状（例えば円板状や楕円板状など）であってもかまわない。また、微小針１２の配列も矩形格子配列、三角格子配列、六角格子配列、同心円状の配列、その他の適宜の配列を使用することが可能である。 By the manufacturing process as described above, a needle-like structure in which a plurality of microneedles 12 are formed on one surface of a flat substrate 11 as shown in FIG. 4 can be obtained. Although FIG. 4 shows a case where the flat substrate 11 has a rectangular shape, it may have another shape (for example, a disk shape or an elliptical plate shape). In addition, the arrangement of the microneedles 12 may be a rectangular lattice arrangement, a triangular lattice arrangement, a hexagonal lattice arrangement, a concentric arrangement, or any other appropriate arrangement.
なお、本発明は以下の発明を開示する。
針状構造物の針形状を転写した転写版に樹脂材を積載する樹脂材積載手段と、前記転写版上の樹脂材を加熱融解する樹脂材加熱手段と、前記融解した樹脂材をプレスして前記転写版の針形状部位に埋設して成形するプレス手段と、前記成形された樹脂材を冷却硬化させる冷却手段と、を有し、前記樹脂材に対して、前記樹脂材加熱手段による加熱および前記プレス手段によるプレスがこの順序で２回以上繰り返されることを特徴とする針状構造物の製造装置。
針状構造物の針形状を転写した転写版に樹脂材を積載する樹脂材積載工程と、前記転写版上の樹脂材を加熱融解する樹脂材加熱工程と、前記融解した樹脂材をプレスして前記転写版の針形状部位に埋設して成形するプレス工程と、前記成形された樹脂材を冷却硬化させる冷却工程と、を有し、前記樹脂材加熱工程および前記プレス工程をこの順序で２回以上繰り返すことを特徴とする針状構造物の製造方法。
針状構造物の針形状を転写した転写版に樹脂材を積載し、前記転写版上の樹脂材を加熱融解する樹脂材加熱過程と、前記融解した樹脂材をプレスして前記転写版の針形状部位に埋設して成形するプレス過程と、前記成形された樹脂材を冷却硬化させる冷却過程と、を経て製造され、前記樹脂材加熱過程および前記プレス過程がこの順序で２回以上繰り返されて製造されることを特徴とする針状構造物。
上記針状構造物において、前記針状構造物の針形状部が、格子状または同心円状に配列されていることを特徴とする針状構造物。
上記針状構造物において、前記転写版に積載される樹脂材が、生分解性樹脂から成ることを特徴とする針状構造物。
The present invention discloses the following invention.
A resin material loading means for loading a resin material on a transfer plate on which the needle shape of the needle-like structure is transferred, a resin material heating means for heating and melting the resin material on the transfer plate, and pressing the melted resin material Press means for embedding and forming in the needle-shaped portion of the transfer plate, and cooling means for cooling and curing the molded resin material, and heating the resin material by the resin material heating means and An apparatus for producing a needle-like structure, wherein pressing by the pressing means is repeated twice or more in this order.
A resin material loading step of loading a resin material on a transfer plate on which the needle shape of the needle-like structure is transferred, a resin material heating step of heating and melting the resin material on the transfer plate, and pressing the molten resin material A pressing step of embedding and forming in the needle-shaped portion of the transfer plate; and a cooling step of cooling and curing the molded resin material, and the resin material heating step and the pressing step are performed twice in this order. A method for producing a needle-like structure, which is repeated as described above.
A resin material is loaded on a transfer plate to which the needle shape of the needle-like structure is transferred, a resin material heating process for heating and melting the resin material on the transfer plate, and the needle of the transfer plate by pressing the melted resin material It is manufactured through a pressing process for embedding in a shape part and molding, and a cooling process for cooling and curing the molded resin material, and the resin material heating process and the pressing process are repeated twice or more in this order. A needle-like structure that is manufactured.
In the needle-like structure, the needle-like portions of the needle-like structure are arranged in a lattice shape or a concentric shape.
In the above needle-like structure, the resin material loaded on the transfer plate is made of a biodegradable resin.
上記に記載の医療用に使用する針状構造物に限らず、基材上に微細な突起物を形成するもの、例えば光反射防止膜、ドット型の光導波路の形成などに適用することが出来る。 The present invention is not limited to the needle-like structures used for medical purposes described above, but can be applied to those that form fine protrusions on a substrate, such as the formation of an antireflection film or a dot-type optical waveguide. .
１・・・エアシリンダ１
２・・・エアシリンダ２
３・・・エアシリンダ３
４・・・エアシリンダ４
５・・・成形枠
６・・・パンチ
７・・・ヒーター
８・・・冷却ノズル
９・・・転写版
１０・・・樹脂材
１１・・・基材
１２・・・微小針
1 ... Air cylinder 1
2 ... Air cylinder 2
3 ... Air cylinder 3
4 ... Air cylinder 4
5 ... Molding frame 6 ... Punch 7 ... Heater 8 ... Cooling nozzle 9 ... Transfer plate 10 ... Resin material 11 ... Base material 12 ... Micro needle
Claims (4)
前記針状構造物の前記微小針形状を転写した転写版と、
前記転写版上の樹脂材を加熱融解する樹脂材加熱手段と、
前記融解した樹脂材をプレスして前記転写版の針形状部位に埋設して成形するプレス手段と、
前記成形された樹脂材を冷却硬化させる冷却手段と、を有し、
前記プレス手段が針状構造物の外形を形作る成形枠と、前記成形枠の内部に配置されるパンチを備えることを特徴とする針状構造物の製造装置。 It is used as a jig for injecting a drug into a specific layer of skin, and is an apparatus for producing a needle-like structure in which a plurality of microneedles are formed on one side of a substrate,
A transfer plate on which the fine needle shape of the needle-like structure is transferred;
Resin material heating means for heating and melting the resin material on the transfer plate;
A pressing means for pressing the molten resin material and embedding it in a needle-shaped portion of the transfer plate; and
Cooling means for cooling and curing the molded resin material,
An apparatus for manufacturing a needle-like structure, wherein the pressing means includes a forming frame that forms an outer shape of the needle-like structure, and a punch disposed inside the forming frame.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0379314A (en) * | 1989-08-22 | 1991-04-04 | Omron Corp | Manufacture of optical part and mold for optical part |
| JP2003089129A (en) * | 2001-09-19 | 2003-03-25 | Matsushita Electric Works Ltd | Smc molding system |
| WO2008062832A1 (en) * | 2006-11-22 | 2008-05-29 | Toppan Printing Co., Ltd. | Microneedle array and process for production thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0379314A (en) * | 1989-08-22 | 1991-04-04 | Omron Corp | Manufacture of optical part and mold for optical part |
| JP2003089129A (en) * | 2001-09-19 | 2003-03-25 | Matsushita Electric Works Ltd | Smc molding system |
| WO2008062832A1 (en) * | 2006-11-22 | 2008-05-29 | Toppan Printing Co., Ltd. | Microneedle array and process for production thereof |
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