JP2013529193A - 非経口栄養から経腸栄養へ離脱させるための栄養組成物及び方法 - Google Patents
非経口栄養から経腸栄養へ離脱させるための栄養組成物及び方法 Download PDFInfo
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- A—HUMAN NECESSITIES
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- A61K9/0012—Galenical forms characterised by the site of application
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
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Abstract
【選択図】なし
Description
ii)カロテン類(例えば、α−カロテン、β−カロテン、γ−カロテン、δ−カロテン、リコペン、ノイロスポレン、フィトフルエン、フィトエン)及びキサントフィル類(例えば、カンタキサンチン、クリプトキサンチン、ゼアキサンチン(aeaxanthin)、アスタキサンチン、ルテイン、ルビキサンチン)を含むカロテノイド類(テトラテルペノイド類);モノテルペン類(例えば、リモネン、ペリリルアルコール);サポニン類;フィトステロール類(例えば、カンペステロール、ベータシトステロール、ガンマシトステロール、スティグマステロール)、トコフェロール類(ビタミンE)及びオメガ−3、6及び9脂肪酸類(例えば、ガンマ−リノレン酸)を含む脂質類;トリテルペノイド類(例えば、オレアノール酸、ウルソール酸、ベツリン酸、モロン酸)を含むテルペン類(イソプレノイド類);
iii)ベータシアニン類(例えば、ベタニン、イソベタニン、プロベタニン、ネオベタニン);及びベータキサンチン類(非グリコシド型)(例えば、インディカキサンチン、バルガキサンチン)を含むベタレイン類;
iv)例えば、ジチオールチオン類(イソチオシアネート)(例えば、スルフォラファン);及びチオスルホネート類(アリウム化合物)(例えば、三硫化アリルメチル、硫化ジアリル)、例えばインドール−3−カルビノール;スルフォラファン;3,3’−ジインドリルメタン;シニグリン;アリシン;アリイン;アリルイソチオシアネート;ピペリン;syn−プロパンチアール−S−オキシドを含む、インドール類、グルコシノレート類を含む有機スルフィド類;
v)例えば、プロテアーゼ阻害剤類を含むタンパク質阻害剤類;
vi)シュウ酸、フィチン酸(イノシトールヘキサホスフェート)、酒石酸、及びアナカルジン酸を含む他の有機酸類;又は
vii)それらの組み合わせ。
栄養組成物処方#1:
体積: 1,000mL
カロリー密度: 0.7kcal/mL
カロリー: 700
タンパク質(AA*含有): エネルギー(ジペプチドを含む)の50%、ホエイ加水分解物
グルタミン(Ala−Glnとして): 20g/L
トレオニン: 3.0g/L
ヌクレオチド: 1.5g/L
炭水化物: エネルギーの30%
脂質: エネルギーの20%
N6:N3: 最大で5:1
MCT:LCT: 40:60
ビタミン&無機塩類: 一日推奨摂取量(「DRI」)を満たし、1,000mL中で安全及び十分なレベル(ビタミンC、ビタミンE及びセレンについてはDRIの2倍)
繊維: 腹部膨満などを引き起こす可溶性及び不溶性繊維は含有せず
*AA=アミノ酸
栄養組成物処方#2:
体積: 1,000mL
カロリー密度: 0.7kcal/mL
カロリー: 700
タンパク質(AA*含有): エネルギーの50%、ホエイ加水分解物
グルタミン(Ala−Glnとして): 20g/L
トレオニン: 2.0g/L
ヌクレオチド: 1.5g/L
炭水化物: エネルギーの30%
脂質: エネルギーの20%
N6:N3: 最大で5:1
MCT:LCT: 40:60
トリブチリン: 4.0g/L
ビタミン&無機塩類: 特別な医学的用途のための食品
繊維: 繊維は含有せず
*AA=アミノ酸
栄養組成物処方#3:
体積: 1,000mL
カロリー密度: 0.7kcal/mL
カロリー: 700
タンパク質(AA*含有): エネルギーの55%、ホエイ加水分解物
グルタミン(Ala−Glnとして): 20g/L
トレオニン: 2.0g/L
ヌクレオチド: 1.5g/L
炭水化物: エネルギーの20%
脂質: エネルギーの25%
N6:N3: 最大で5:1
MCT:LCT: 40:60
トリブチリン: 10.0g/L
ビタミン&無機塩類: 特別な医学的用途のための食品
繊維: 繊維は含有せず
*AA=アミノ酸
栄養組成物処方#4:
体積: 1,000mL
カロリー密度: 0.7kcal/mL
カロリー: 700
タンパク質(AA*含有): エネルギーの50%、カゼイン加水分解物
グルタミン(Ala−Glnとして): 20g/L
トレオニン: 2.0g/L
システイン: 2.0g/L
ヌクレオチド: 1.5g/L
炭水化物: エネルギーの25%
脂質: エネルギーの25%
N6:N3: 最大で5:1
MCT:LCT: 40:60
ビタミン&無機塩類: 下記を除き、特別な医学的用途のための食品
ビタミンC: 380mg
ビタミンE: 120mg
セレン: 200mcg
繊維: 繊維は含有せず
*AA=アミノ酸
栄養組成物処方#5:
体積: 1,000mL
カロリー密度: 0.8kcal/mL
カロリー: 800
タンパク質(AA*含有): エネルギーの50%、カゼイン
グルタミン(Ala−Glnとして): 20g/L
トレオニン: 2.0g/L
ヌクレオチド: 1.5g/L
炭水化物: エネルギーの30%
脂質: エネルギーの20%
N6:N3: 最大で5:1
MCT:LCT: 40:60
ビタミン&無機塩類: 下記を除き、特別な医学的用途のための食品
ビタミンC: 380mg
ビタミンE: 120mg
セレン: 200mcg
繊維: 繊維は含有せず
*AA=アミノ酸
[00103]実施例6〜9は、それぞれ実施例2〜5の処方であるが、タンパク質供給源(例えば、ホエイ加水分解物、カゼイン加水分解物若しくはカゼイン)にジペプチドを含む処方を含むものである。
Claims (22)
- タンパク質とアミノ酸と外因性ヌクレオチドとを含む栄養組成物であって、
前記タンパク質は栄養組成物の全エネルギーの約35%〜約55%であり、前記タンパク質は、インタクトなタンパク質、遊離アミノ酸、ホエイタンパク質加水分解物、カゼイン加水分解物、ミルクタンパク質加水分解物、ダイズタンパク質加水分解物、エンドウマメタンパク質加水分解物及びその組み合わせからなる群から選択され、
前記アミノ酸は約20グラム〜約40グラムの量であり、前記アミノ酸は、グルタミン供給源、トレオニン供給源、システイン供給源、セリン供給源、プロリン供給源及びその組み合わせからなる群から選択され、
前記外因性ヌクレオチドは約1〜約4の量である、
栄養組成物。 - 前記グルタミン供給源は、グルタミンジペプチド、グルタミン濃縮コムギタンパク質及びその組み合わせからなる群から選択される、請求項1に記載の栄養組成物。
- 前記外因性ヌクレオチドは、5’−アデノシンモノホスフェート、5’−グアノシンモノホスフェート、5’−シトシンモノホスフェート、5’−ウラシルモノホスフェート、5’−イノシンモノホスフェート、5’−チミンモノホスフェート及びその組み合わせからなる群から選択される単量体の形態である、請求項1に記載の栄養組成物。
- 前記外因性ヌクレオチドはインタクトなリボ核酸である、請求項1に記載の栄養組成物。
- 脂質、炭水化物、抗酸化物質、ビタミン、無機塩類、繊維、シンバイオティクス、プロバイオティクス、植物栄養素及びその組み合わせの少なくとも1種をさらに含む、請求項1に記載の栄養組成物。
- 前記脂質は、短鎖トリグリセリド、中鎖トリグリセリド、長鎖トリグリセリド、魚油、植物油及びその組み合わせからなる群から選択される、請求項5に記載の栄養組成物。
- 前記繊維は、ガラクトオリゴ糖、フラクトオリゴ糖、フコオリゴ糖、キシロオリゴ糖、パラチノースオリゴ糖、ダイズオリゴ糖、ゲンチオオリゴ糖、イヌリン、ペクチン、ペクチン酸塩、アルギン酸塩、コンドロイチン、ヒアルロン酸、ヘパリン、ヘパラン、シアログリカン、フコイダン、カラギーナン、キサンタンガム、セルロース、ポリデキストロース、部分的に加水分解されたグアーガム、グアーガム及びその組み合わせからなる群から選択される、請求項5に記載の栄養組成物。
- 前記プロバイオティクスは、サッカロミセス、デバロミセス、カンジダ、ピキア、トルロプシス、アスペルギルス、リゾプス、ムコール、ペニシリウム、トルロプシス、ビフィドバクテリウム、バクテロイデス、クロストリジウム、フソバクテリウム、メリソコッカス、プロピオニバクテリウム、ストレプトコッカス、エンテロコッカス、ラクトコッカス、スタフィロコッカス、ペプトストレプトコッカス、バチルス、ペディオコッカス、ミクロコッカス、リューコノストック、ウイッセラ、アエロコッカス、オエノコッカス、ラクトバチルス及びその組み合わせからなる群から選択される、請求項5に記載の栄養組成物。
- 栄養組成物を調製する方法であって、請求項1に記載のタンパク質、アミノ酸及び内因性ヌクレオチドを組み合わせて栄養組成物を形成するステップを含む方法。
- 脂質、炭水化物、抗酸化物質、ビタミン、無機塩類、繊維、シンバイオティクス、プロバイオティクス、植物栄養素及びその組み合わせの少なくとも1種を組み合わせるステップをさらに含む、請求項9に記載の方法。
- 前記栄養組成物は、薬剤処方、栄養処方、栄養補助食品、機能性食品、飲料製品及びその組み合わせからなる群から選択される投与可能形態である、請求項9又は請求項10に記載の方法。
- 患者に栄養を与える方法であって、
患者に非経口栄養を与えるステップと、
以前に非経口的に栄養を受けていた患者に、請求項1に記載の栄養組成物を含む離脱栄養組成物を投与するステップと、
を含む方法。 - 前記グルタミン供給源は、グルタミンジペプチド、グルタミン濃縮コムギタンパク質及びその組み合わせからなる群から選択される、請求項12に記載の方法。
- 前記外因性ヌクレオチドは、5’−アデノシンモノホスフェート、5’−グアノシンモノホスフェート、5’−シトシンモノホスフェート、5’−ウラシルモノホスフェート、5’−イノシンモノホスフェート、5’−チミンモノホスフェート及びその組み合わせからなる群から選択される単量体の形態である、請求項12に記載の方法。
- 前記外因性ヌクレオチドはインタクトなリボ核酸である、請求項12に記載の方法。
- 前記離脱栄養組成物は、脂質、炭水化物、抗酸化物質、ビタミン、無機塩類、繊維、シンバイオティクス、プロバイオティクス、植物栄養素及びその組み合わせの少なくとも1種をさらに含む、請求項12に記載の方法。
- 前記脂質は、短鎖トリグリセリド、中鎖トリグリセリド、長鎖トリグリセリド、魚油、植物油及びその組み合わせからなる群から選択される、請求項16に記載の方法。
- 前記繊維は、ガラクトオリゴ糖、フラクトオリゴ糖、フコオリゴ糖、キシロオリゴ糖、パラチノースオリゴ糖、ダイズオリゴ糖、ゲンチオオリゴ糖、イヌリン、ペクチン、ペクチン酸塩、アルギン酸塩、コンドロイチン、ヒアルロン酸、ヘパリン、ヘパラン、シアログリカン、フコイダン、カラギーナン、キサンタンガム、セルロース、ポリデキストロース、部分的に加水分解されたグアーガム、グアーガム及びその組み合わせからなる群から選択される、請求項16に記載の方法。
- 前記プロバイオティクスは、サッカロミセス、デバロミセス、カンジダ、ピキア、トルロプシス、アスペルギルス、リゾプス、ムコール、ペニシリウム、トルロプシス、ビフィドバクテリウム、バクテロイデス、クロストリジウム、フソバクテリウム、メリソコッカス、プロピオニバクテリウム、ストレプトコッカス、エンテロコッカス、ラクトコッカス、スタフィロコッカス、ペプトストレプトコッカス、バチルス、ペディオコッカス、ミクロコッカス、リューコノストック、ウイッセラ、アエロコッカス、オエノコッカス、ラクトバチルス及びその組み合わせからなる群から選択される、請求項16に記載の方法。
- 約500mL〜約1000mLの離脱栄養組成物を最初の24時間投与した後、より長い期間、経腸的に経腸栄養組成物を投与するステップを含む、請求項12に記載の方法。
- 前記患者は完全非経口栄養投与から完全経腸栄養投与へと離脱している、請求項12に記載の方法。
- 前記栄養組成物は、薬剤処方、栄養処方、栄養補助食品、機能性食品、飲料製品及びその組み合わせからなる群から選択される投与可能形態である、請求項12に記載の方法。
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JP2019004906A (ja) * | 2018-09-12 | 2019-01-17 | 株式会社ファンケル | フラボノイド類含有粉末組成物 |
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CN107744017A (zh) * | 2017-06-27 | 2018-03-02 | 中食月太(北京)健康科技有限公司 | 一种含水解酪蛋白的益生菌固体饮料及其制备方法 |
US10682325B2 (en) | 2017-08-14 | 2020-06-16 | Axcella Health Inc. | Compositions and methods for the treatment of liver diseases and disorders associated with one or both of hyperammonemia or muscle wasting |
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EP3810123A1 (en) | 2018-06-20 | 2021-04-28 | Axcella Health Inc. | Compositions and methods for the treatment of fat infiltration in muscle |
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- 2011-04-25 CA CA2796936A patent/CA2796936A1/en not_active Abandoned
- 2011-04-25 BR BR112012027427A patent/BR112012027427A2/pt not_active IP Right Cessation
- 2011-04-25 JP JP2013508118A patent/JP2013529193A/ja active Pending
- 2011-04-25 WO PCT/US2011/033729 patent/WO2011139621A1/en active Application Filing
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JP2019517246A (ja) * | 2016-06-10 | 2019-06-24 | ネステク ソシエテ アノニム | 乳清タンパク質ミセルを含む乳清タンパク質及びカゼイン供給源を有する加熱殺菌された高タンパク質経腸組成物 |
JP2019517245A (ja) * | 2016-06-10 | 2019-06-24 | ネステク ソシエテ アノニム | 乳清タンパク質ミセルを含む乳清タンパク質及びカゼイン供給源を有する加熱殺菌された高タンパク質経腸組成物 |
JP2021520197A (ja) * | 2018-04-23 | 2021-08-19 | エボニック オペレーションズ ゲーエムベーハー | シンバイオティクス組成物 |
JP7407120B2 (ja) | 2018-04-23 | 2023-12-28 | エボニック オペレーションズ ゲーエムベーハー | シンバイオティクス組成物 |
JP2019004906A (ja) * | 2018-09-12 | 2019-01-17 | 株式会社ファンケル | フラボノイド類含有粉末組成物 |
Also Published As
Publication number | Publication date |
---|---|
EP2563168A1 (en) | 2013-03-06 |
CN103025178A (zh) | 2013-04-03 |
CA2796936A1 (en) | 2011-11-10 |
US20130210715A1 (en) | 2013-08-15 |
CN103025178B (zh) | 2015-02-11 |
WO2011139621A1 (en) | 2011-11-10 |
BR112012027427A2 (pt) | 2015-09-15 |
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