JP2013506855A - マイクロフルイディック部品の接合方法及び接合部 - Google Patents
マイクロフルイディック部品の接合方法及び接合部 Download PDFInfo
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- JP2013506855A JP2013506855A JP2012532567A JP2012532567A JP2013506855A JP 2013506855 A JP2013506855 A JP 2013506855A JP 2012532567 A JP2012532567 A JP 2012532567A JP 2012532567 A JP2012532567 A JP 2012532567A JP 2013506855 A JP2013506855 A JP 2013506855A
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Abstract
Description
2 第2の板状基体
3 フィルム
4 チャネル
5 充填開口部
6 ピン
7 ボア
8 摩擦連結部
9 ヘッド
10 止まり穴
11 密封リップ
12 サーモード
13 支持体
14 メンブレン
15 フィルム
16 接着層/密封層
17 入口チャンバ
18 通気トレンチ
19 通気チャネル
20 カートリッジ
21 分析チャンバ
22 固定面
23 保持手段
24 引張り力
29 成形物
Claims (25)
- 診断分析機器用のマイクロフルイディックカートリッジであって、
第1の板状基体(1)、第2の板状基体(2)及び前記板状基体(1,2)相互間に配置されたフィルム(3)を有し、
チャネル(4)が前記基体(1,2)の一方又は前記フィルムに設けられた凹部によって形成され、
前記板状基体(1,2)は、前記チャネルにサンプル液体を充填する充填開口部(5)を有するマイクロフルイディックカートリッジにおいて、前記板状基体(1,2)の一方に一体に連結されたピン(6)が前記フィルム及び関連の前記基体(1,2)のそれぞれに設けられた関連のボア(7)内に突き出ており、前記ピンの変形により、前記関連の基体(1,2)にインターロック係合関係をなして当接する成形部、特に前記基体に当接するヘッド(9)が形成されている、
ことを特徴とするマイクロフルイディックカートリッジ。 - 前記ピン(6)は、前記変形後に前記ボアを少なくとも部分的に埋め、その結果、前記ピンの周面と前記ボア(7)の壁が局所的に摩擦係合部(8)を形成するようになっている、
請求項1記載のマイクロフルイディックカートリッジ。 - 前記ピン(6)の接合部の摩擦インターロック係合強度は、前記基体材料の引張り強度の少なくとも10%、より好ましくは少なくとも25%に等しい、
請求項2記載のマイクロフルイディックカートリッジ。 - 前記接合部は、平均で5N、特に10Nの引張り応力に耐える、
請求項3記載のマイクロフルイディックカートリッジ。 - 前記ピン(6)は、円錐形である、
請求項1又は2記載のマイクロフルイディックカートリッジ。 - 前記ピン(6)と関連した前記ボア(7)の直径は、前記ピンの基部の直径の1〜2倍に一致する、
請求項1又は5記載のマイクロフルイディックカートリッジ。 - 前記ピンの前記ヘッドの端部では、前記ボア(7)は、前記ヘッド(9)が成形により収納される止まり穴(10)の形態をなして直径が大きくなっている、
請求項1又は2記載のマイクロフルイディックカートリッジ。 - 前記ピンの直径は、0.2mm〜5mm、特に0.5mm〜1.5mmである、
請求項1ないし7のいずれか1項に記載のマイクロフルディックカートリッジ。 - 前記フィルム(3)は、前記板状基体(1,2)の一方にぴったりと接合され、特に、接着層(16)によって貼り付けられている、
請求項1ないし8のいずれか1項に記載のマイクロフルイディックカートリッジ。 - 前記接着層(16)は、粘着層又は密封層である、
請求項1ないし9のいずれか1項に記載のマイクロフルイディックカートリッジ。 - 前記接着層(16)は、両面接着フィルム(16)である、
請求項10記載のマイクロフルイディックカートリッジ。 - 前記基体材料は、PS、PMMA、PC、COC、COP、PP、PE又はPEEKの中から選択されたプラスチックである、
請求項1ないし11のいずれか1項に記載のマイクロフルイディックカートリッジ。 - 複数本のピンが前記第1の板状基体(1)の表面から突き出て、前記第2の板状基体(2)、特にカバー要素(2)に設けられたボア(7)内に嵌まり込んでいる、
請求項1又は2記載のマイクロフルイディックカートリッジ。 - 複数本のピンが前記第2の板状基体(1)、特にカバー要素(2)から突き出て、前記第1の板状基体(1)に設けられたボア(7)内に嵌まり込んでいる、
請求項1又は2記載のマイクロフルイディックカートリッジ。 - 前記ピンの平均直径は、0.2mm〜5mm、特に0.5mm〜2mmである、
請求項1又は2記載のマイクロフルイディックカートリッジ。 - 前記フィルム(3)は、シールを形成するよう前記ピン(6)に当接している、
請求項1ないし15のいずれか1項に記載のマイクロフルイディックカートリッジ。 - 前記基体の少なくとも一方は、前記充填開口部の付近に少なくとも1つの密封リップ(11)を有する、
請求項1ないし16のいずれか1項に記載のマイクロフルイディックカートリッジ。 - 前記密封リップ(11)は、前記充填開口部(5)を連続的に包囲している、
請求項17記載のマイクロフルイディックカートリッジ。 - 前記密封リップ(11)は、前記基体(1,2)に一体に連結されると共にくさび形、カッタ形又は環状の形をなして先細になった状態で前記基体表面から突き出ており、組立てプロセス後、形成済みの前記密封リップ(11)のカッタを前記フィルム中に押し込んでインターロック係合によりシールを形成する、
請求項17又は18記載のマイクロフルイディックカートリッジ。 - 前記密封リップ(11)は、包囲弾性シールである、
請求項17又は18記載のマイクロフルイディックカートリッジ。 - 請求項1ないし20のいずれか1項に記載のマイクロフルイディックカートリッジ(20)を製造する方法であって、第1ステップでは、板状基体(1,2)及び前記板状基体(1,2)相互間に配置されたフィルム(3)を支持体(13)上に積み重ね、次のステップでは、加圧ツールを所定の圧力Pでピン(6)のヘッド端部に配置し、熱を溶接時間ts中、前記ピン(6)に導入し、前記ピン材料をそのガラス転移温度及び/又は溶融温度よりも高く昇温させ、前記ピン材料がボア(7)内で流れて前記ピン(6)と前記ボア(7)の壁との間に摩擦連結部が形成され、前記基体(1,2)及び前記フィルム(3)は、接合連結部が硬化する保持時間tH全体にわたって圧縮状態のままであるようにする、
ことを特徴とする方法。 - 円錐形先端部を備えた1つ又は2つ以上のロッド状サーモード(12)を前記加圧ツールとして用い、前記円錐形先端部は、変形されるべき材料の中央に当てられ、接触箇所から出た熱により、前記ピン材料の塑性流れ及び圧縮が生じる、
請求項20記載の方法。 - 選択された前記基体材料に応じて、前記加圧ツールの温度は、
・PS 100℃〜180℃、特に130℃〜150℃、
・PMMA 100℃〜180℃、特に130℃〜150℃、
・PC 140℃〜230℃、特に160℃〜190℃、
・COP及びCOC 100℃〜240℃、特に170℃〜210℃、
・PE 80℃〜170℃、特に100℃〜140℃、
・PP 90℃〜200℃、特に120℃〜170℃、
・PPEK 160℃〜250℃、特に180℃〜210℃である、
請求項20記載の方法。 - 0.5秒よりも長く、特に1.5〜5秒の溶接時間tsが利用される、
請求項20ないし22のいずれか1項に記載の方法。 - 前記接合プロセス中、前記加圧ツールは、0.5バール〜5バール、特に1.5バール〜3バールの圧力で前記マイクロフルイディックカートリッジ(20)に作用し、又は前記ピン形サーモード(12)は、接合プロセス中、25ニュートン〜1キロニュートンの力で前記マイクロフルイディックカートリッジ(20)に作用する、
請求項20ないし23のいずれか1項に記載の方法。
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US20140170678A1 (en) | 2012-12-17 | 2014-06-19 | Leukodx Ltd. | Kits, compositions and methods for detecting a biological condition |
US10610861B2 (en) | 2012-12-17 | 2020-04-07 | Accellix Ltd. | Systems, compositions and methods for detecting a biological condition |
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Also Published As
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US9333707B2 (en) | 2016-05-10 |
EP2485841A1 (de) | 2012-08-15 |
WO2011042422A1 (de) | 2011-04-14 |
US20120275972A1 (en) | 2012-11-01 |
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