JP2013505720A - Nutritional composition comprising theanine and exogenous nucleotide - Google Patents
Nutritional composition comprising theanine and exogenous nucleotide Download PDFInfo
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- JP2013505720A JP2013505720A JP2012530892A JP2012530892A JP2013505720A JP 2013505720 A JP2013505720 A JP 2013505720A JP 2012530892 A JP2012530892 A JP 2012530892A JP 2012530892 A JP2012530892 A JP 2012530892A JP 2013505720 A JP2013505720 A JP 2013505720A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/13—Nucleic acids or derivatives thereof
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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Abstract
栄養組成物、並びに栄養組成物を作製及び使用する方法を提供する。本開示は、一般的な実施形態において、テアニン及び1種又は複数の外因性ヌクレオチドを含む栄養組成物を提供する。栄養組成物は、特に、炎症性腸症候群を含む腸機能障害を治療するために使用することができる。 Nutritional compositions and methods of making and using the nutritional compositions are provided. The present disclosure, in general embodiments, provides a nutritional composition comprising theanine and one or more exogenous nucleotides. The nutritional composition can be used in particular to treat bowel dysfunction, including inflammatory bowel syndrome.
Description
[0001]本開示は、全般的には、健康及び栄養に関する。本開示は、特に、テアニン及び外因性ヌクレオチドを含む栄養組成物、並びに該栄養組成物を作製及び使用する方法に関する。 [0001] The present disclosure relates generally to health and nutrition. The present disclosure particularly relates to nutritional compositions comprising theanine and exogenous nucleotides, and methods of making and using the nutritional compositions.
[0002]多くの種類の栄養組成物が現在市販されている。栄養組成物は、栄養組成物の具体的な成分に基づいて、特定の消費者タイプ、例えば若年層、年配層、スポーツ愛好者等を対象とすることが可能である。栄養組成物は、栄養組成物で治療又は改善することを意図する特定の生理学的状態に基づいて処方することもできる。 [0002] Many types of nutritional compositions are currently on the market. The nutritional composition can be targeted to specific consumer types, such as young, senior, sports enthusiasts, etc., based on the specific ingredients of the nutritional composition. The nutritional composition can also be formulated based on a particular physiological condition intended to be treated or ameliorated with the nutritional composition.
[0003]蔓延している特定の生理学的状態には、過敏性腸症候群(「IBS」)及び他の腸機能障害が含まれる。IBS及び他の腸機能障害状態は、腹痛、筋痙攣、腹部膨満、下痢及び/又は便秘で特徴付けることができる。IBS及び他の腸機能障害によって、多くの不快感及び苦痛が生じるが、腸を永続的に害するわけではなく、重病に至ることもない。人によっては、IBS及び他の腸機能障害によって、仕事、社会行事への参加、又は短い距離の移動でさえもできないため、日常に支障を来すことがある。大人人口の20パーセントもの人々、すなわち米国人の5人に1人がIBS及び他の腸機能障害の症状を有し、医師の診断による最もよくある障害の1つになっている。 [0003] Certain prevalent physiological conditions include irritable bowel syndrome ("IBS") and other intestinal dysfunctions. IBS and other intestinal dysfunction conditions can be characterized by abdominal pain, muscle cramps, abdominal distension, diarrhea and / or constipation. IBS and other intestinal dysfunctions cause a lot of discomfort and pain, but do not permanently harm the intestines and do not lead to serious illness. In some people, IBS and other bowel dysfunctions can interfere with daily life because they cannot work, participate in social events, or even travel short distances. As many as 20 percent of the adult population, one in five Americans, has symptoms of IBS and other bowel dysfunction, making it one of the most common disorders as diagnosed by physicians.
[0004]テアニン及び外因性ヌクレオチドを含む栄養組成物、並びに該栄養組成物を作製及び使用する方法を提供する。本開示は、全般的な実施形態において、テアニン及び1種又は複数の外因性ヌクレオチドを含む栄養組成物を提供する。栄養組成物は、完全な摂食物又は経口栄養補助食品とすることができる。 [0004] Nutritional compositions comprising theanine and exogenous nucleotides and methods of making and using the nutritional compositions are provided. The present disclosure, in general embodiments, provides a nutritional composition comprising theanine and one or more exogenous nucleotides. The nutritional composition can be a complete food intake or an oral dietary supplement.
[0005]栄養組成物は、ヒト又は動物等の任意の哺乳類用に設計された製剤であることができる。栄養組成物中の活性成分は、モジュール製品として供給することもできる。モジュール製品とは、1つ又は複数の特定の栄養素をサプリメントとして送達する方法と定義することができ、唯一の栄養供給源として使用することを意図するものではない。さらに、栄養組成物は常温保存ができ、周囲温度、又は流通中に生じることのある周囲温度を超える温度でも保存性が良好である。 [0005] The nutritional composition can be a formulation designed for any mammal, such as a human or animal. The active ingredient in the nutritional composition can also be supplied as a modular product. A modular product can be defined as a method of delivering one or more specific nutrients as a supplement and is not intended to be used as the sole nutrient source. Furthermore, the nutritional composition can be stored at room temperature and has good storage stability even at ambient temperatures or temperatures exceeding ambient temperatures that may occur during distribution.
[0006]外因性ヌクレオチドは、単量体型、例えば、5’−アデノシン一リン酸(「5’−AMP」)、5’−グアノシン一リン酸(「5’−GMP」)、5’−シトシン一リン酸(「5’−CMP」)、5’−ウラシル一リン酸(「5’−UMP」)、5’−イノシン一リン酸(「5’−IMP」)、5’−チミン一リン酸(「5’−TMP」)又はこれらの組合せ等とすることができる。外因性ヌクレオチドは、多量体型、例えば、未処理のリボ核酸等とすることもできる。 [0006] Exogenous nucleotides are monomeric, such as 5'-adenosine monophosphate ("5'-AMP"), 5'-guanosine monophosphate ("5'-GMP"), 5'-cytosine. Monophosphate (“5′-CMP”), 5′-uracil monophosphate (“5′-UMP”), 5′-inosine monophosphate (“5′-IMP”), 5′-thymine monophosphate It can be an acid (“5′-TMP”) or a combination thereof. Exogenous nucleotides can also be multimeric, eg, untreated ribonucleic acid.
[0007]一実施形態では、栄養組成物は1つ又は複数のプレバイオティクスを更に含む。プレバイオティクスは、アカシアゴム、αグルカン、βグルカン、フラクトオリゴ糖、ガラクトオリゴ糖、ゲンチオオリゴ糖、グルコオリゴ糖、グアーガム、イヌリン、イソマルトオリゴ糖、ラクトスクロース、ラクツロース、部分加水分解グアーガム、ペクチンオリゴ糖、大豆オリゴ糖、糖アルコール、キシロオリゴ糖、又はこれらの組合せとすることができる。又はこれらの組合せ。 [0007] In one embodiment, the nutritional composition further comprises one or more prebiotics. Prebiotics include acacia gum, α-glucan, β-glucan, fructooligosaccharide, galactooligosaccharide, gentio-oligosaccharide, gluco-oligosaccharide, guar gum, inulin, isomalt-oligosaccharide, lactosucrose, lactulose, partially hydrolyzed guar gum, pectin oligosaccharide, soybean oligo It can be a sugar, sugar alcohol, xylooligosaccharide, or a combination thereof. Or a combination of these.
[0008]一実施形態では、栄養組成物は、1つ又は複数のプロバイオティクスを更に含む。プロバイオティクスは、サッカロマイセス属(Saccharomyces)、デバロマイセス属(Debaromyces)、カンジダ属(Candida)、ピキア属(Pichia)、トルロプシス属(Torulopsis)、アスペルギルス属(Aspergillus)、リゾプス属(Rhizopus)、ケカビ属(Mucor)、ペニシリウム属(Penicillium)、ビフィドバクテリウム属(Bifidobacterium)、バクテロイデス属(Bacteroides)、クロストリジウム属(Clostridium)、フソバクテリウム属(Fusobacterium)、メリソコッカス属(Melissococcus)、プロピオニバクテリウム属(Propionibacterium)、ストレプトコッカス属(Streptococcus)、エンテロコッカス属(Enterococcus)、ラクトコッカス属(Lactococcus)、スタフィロコッカス属(Staphylococcus)、ペプトストレプトコッカス属(Peptostreptococcus)、バチルス属(Bacillus)、ペディオコッカス属(Pediococcus)、ミクロコッカス属(Micrococcus)、ロイコノストック属(Leuconostoc)、ワイセラ属(Weissella)、アエロコッカス属(Aerococcus)、オエノコッカス属(Oenococcus)、ラクトバチルス属(Lactobacillus)又はこれらの組合せとすることができる。 [0008] In one embodiment, the nutritional composition further comprises one or more probiotics. Probiotics include: Saccharomyces, Debaromyces, Candida, Pichia, Torulopsis, Aspergillus, Rhizopus, Rhizopus, Rhizopus Mucor, Penicillium, Bifidobacterium, Bacteroides, Clostridium, Fusobacterium, Prosococcus (us) , Su Streptococcus, Enterococcus, Lactococcus, Staphylococcus, Peptostreptoccus, Bacillus, C It can be Micrococcus, Leuconostoc, Weissella, Aerococcus, Oenococcus, Lactobacillus or a combination thereof.
[0009]別の実施形態では、栄養組成物は、1種又は複数のアミノ酸を更に含む。アミノ酸は、アラニン、アルギニン、アスパラギン、アスパラギン酸、システイン、グルタミン酸、グルタミン、グリシン、ヒスチジン、イソロイシン、ロイシン、リシン、メチオニン、フェニルアラニン、プロリン、セリン、スレオニン、トリプトファン、チロシン、及びバリン、又はこれらの組合せとすることができる。 [0009] In another embodiment, the nutritional composition further comprises one or more amino acids. Amino acids are alanine, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, and valine, or combinations thereof can do.
[0010]一実施形態では、栄養組成物は、1つ又は複数のシンバイオティクス、魚油、フィトニュートリエント、酸化防止剤、及び/又は部分加水分解グアーガムを更に含む。 [0010] In one embodiment, the nutritional composition further comprises one or more symbiotics, fish oil, phytonutrients, antioxidants, and / or partially hydrolyzed guar gum.
[0011]一実施形態では、栄養組成物は、医薬製剤、栄養製剤、健康補助食品、機能性食品、飲料製品、又はこれらの組合せ等の投与可能な形態である。 [0011] In one embodiment, the nutritional composition is in an administrable form such as a pharmaceutical formulation, a nutritional formulation, a dietary supplement, a functional food, a beverage product, or a combination thereof.
[0012]本開示は、別の実施形態において、栄養組成物を作製する方法を提供する。かかる方法は、テアニン及び外因性ヌクレオチドを栄養組成物に添加することを含む。 [0012] The present disclosure, in another embodiment, provides a method of making a nutritional composition. Such a method includes adding theanine and exogenous nucleotides to the nutritional composition.
[0013]本開示は、他の実施形態において、個体又は哺乳類の過敏性腸症候群を治療する方法を提供する。かかる方法は、投与を必要とする個体又は哺乳類に、有効量のテアニン及び1種又は複数の外因性ヌクレオチドを含む栄養組成物を投与することを含む。 [0013] The present disclosure, in other embodiments, provides a method of treating irritable bowel syndrome in an individual or mammal. Such methods include administering to an individual or mammal in need thereof a nutritional composition comprising an effective amount of theanine and one or more exogenous nucleotides.
[0014]本開示の利点は、テアニン及び外因性ヌクレオチドを含む改良型栄養組成物を提供することである。 [0014] An advantage of the present disclosure is to provide improved nutritional compositions comprising theanine and exogenous nucleotides.
[0015]本開示の別の利点は、改良型栄養組成物を作製する方法を提供することである。 [0015] Another advantage of the present disclosure is to provide a method of making an improved nutritional composition.
[0016]本開示のさらなる別の利点は、過敏性腸症候群を治療する栄養組成物を提供することである。 [0016] Yet another advantage of the present disclosure is to provide a nutritional composition for treating irritable bowel syndrome.
[0017]さらなる特徴及び利点は、本明細書に記載され、以下の詳細な説明から明らかとなるであろう。 [0017] Additional features and advantages are described herein and will be apparent from the following detailed description.
[0018]本開示は、テアニン及び外因性ヌクレオチドを含む栄養組成物、並びに該栄養組成物を作製及び使用する方法に関する。本開示の栄養組成物の実施形態は、脳腸相関を利用でき、IBS及び他の腸機能障害の患者の自覚ストレス及び不安レベルをテアニンが低減することができる。ヌクレオチドと組み合わせたテアニンは血流を改善すること、及び、速やかに細胞を***させるための、予め形成した物質を供給することができ、この物質は、例えばバリア、消化酵素レベル及び免疫等の胃腸管の機能を改善し、それによって腸機能障害の症状を軽減することができる。部分加水分解グアーガム等の任意選択の成分は、IBS及び他の腸機能障害の症状を更に改善し得る。 [0018] The present disclosure relates to nutritional compositions comprising theanine and exogenous nucleotides, and methods of making and using the nutritional compositions. Embodiments of the nutritional composition of the present disclosure can utilize brain-intestinal correlations and theanine can reduce subjective stress and anxiety levels in patients with IBS and other bowel dysfunctions. Theanine in combination with nucleotides can provide a pre-formed substance to improve blood flow and rapidly divide cells, such as gastrointestinal tracts such as barriers, digestive enzyme levels and immunity Can improve the function of the ducts, thereby reducing the symptoms of bowel dysfunction. Optional ingredients such as partially hydrolyzed guar gum may further improve symptoms of IBS and other bowel dysfunction.
[0019]本開示は、全般的な実施形態において、テアニン及び1種又は複数の外因性ヌクレオチドを含む栄養組成物を提供する。これら2つの成分の組合せは、IBS及び他の腸機能障害の患者において、脳腸相関を標的にすることにより相乗的な利益をもたらし、それによりヌクレオチドが示す利益を更に向上させることができる。 [0019] The present disclosure provides, in general embodiments, a nutritional composition comprising theanine and one or more exogenous nucleotides. The combination of these two components can provide a synergistic benefit in targeting patients with IBS and other bowel dysfunction by targeting brain-intestinal correlation, thereby further improving the benefits that nucleotides exhibit.
[0020]テアニン(γ−グルタミルエチルアミド又は5−N−エチル−グルタミン)は、茶(カメリアシネンシス(Camellia sinensis)の浸出液)、及び担子菌キノコであるボレトゥスバディウス(Boletus badius)にもよく見出されるグルタミン酸類似体又はアミノ酸誘導体である。外因性ヌクレオチドは、例えば、細胞のエネルギー充足を改善し、その結果タンパク質合成を含む同化プロセスを維持する細胞の能力の維持に役立つ栄養組成物の一部として、単量体型であっても多量体型であってもよい。 [0020] Theanine (γ-glutamylethylamide or 5-N-ethyl-glutamine) is also good for tea (Camelia sinensis leachate) and basidiomycete mushroom Boletus badius It is a glutamic acid analog or amino acid derivative that is found. Exogenous nucleotides are, for example, part of a nutritional composition that helps to maintain the cell's ability to improve cell energy sufficiency and thus maintain an anabolic process including protein synthesis, even in monomeric or multimeric form. It may be.
[0021]ヌクレオチドは、デオキシリボ核酸(「DNA」)又はリボ核酸(「RNA」)のサブユニットである。ヌクレオチドは、窒素塩基、リン酸分子、及び糖分子(DNAではデオキシリボース、及びRNAではリボース)から成る有機化合物である。個々のヌクレオチド単量体(単独ユニット)が結合し合って多量体、すなわち長鎖を形成する。本開示の実施形態における外因性ヌクレオチドは、具体的には栄養素補充によって供給される。 [0021] A nucleotide is a subunit of deoxyribonucleic acid ("DNA") or ribonucleic acid ("RNA"). Nucleotides are organic compounds composed of nitrogen bases, phosphate molecules, and sugar molecules (deoxyribose for DNA and ribose for RNA). Individual nucleotide monomers (single units) combine to form a multimer, ie, a long chain. Exogenous nucleotides in embodiments of the present disclosure are specifically supplied by nutrient supplementation.
[0022]外因性ヌクレオチドは、単量体型、例えば、5’−アデノシン一リン酸(「5’−AMP」)、5’−グアノシン一リン酸(「5’−GMP」)、5’−シトシン一リン酸(「5’−CMP」)、5’−ウラシル一リン酸(「5’−UMP」)、5’−イノシン一リン酸(「5’−IMP」)、5’−チミン一リン酸(「5’−TMP」)又はこれらの組合せ等とすることができる。外因性ヌクレオチドは、多量体型、例えば、未処理のRNA等とすることもできる。また、例えば酵母RNA等、多量体型の複数の供給源が存在し得る。 [0022] Exogenous nucleotides can be monomeric, eg, 5'-adenosine monophosphate ("5'-AMP"), 5'-guanosine monophosphate ("5'-GMP"), 5'-cytosine. Monophosphate (“5′-CMP”), 5′-uracil monophosphate (“5′-UMP”), 5′-inosine monophosphate (“5′-IMP”), 5′-thymine monophosphate It can be an acid (“5′-TMP”) or a combination thereof. Exogenous nucleotides can also be multimeric, such as untreated RNA. There can also be multiple multimeric sources such as yeast RNA.
[0023]本明細書で使用する場合、「栄養組成物」という用語は、完全型栄養組成物、部分型又は不完全型栄養組成物、及び疾患又は状態に特異的な栄養組成物を含むが、これらに限定されるものではない。完全型栄養組成物(すなわち、全ての必須の主要及び微量栄養素を含有するもの)は、唯一の栄養源として患者に使用することができる。患者は、かかる完全型栄養組成物から、自己の栄養必要量の100%を摂取することができる。部分型又は不完全型栄養組成物は、必須の主要及び微量栄養素を全て含有するわけではなく、唯一の栄養源として患者に使用することはできない。部分型又は不完全型栄養組成物は、栄養補助食品として使用することができる。疾患又は状態に特異的な栄養組成物は、栄養素又は医薬品を送達する組成物であり、完全型又は部分型栄養組成物であってもよい。 [0023] As used herein, the term "nutrition composition" includes complete nutritional compositions, partial or incomplete nutritional compositions, and nutritional compositions specific for a disease or condition. However, it is not limited to these. A complete nutritional composition (ie one containing all essential macro and micro nutrients) can be used by the patient as the sole source of nutrition. Patients can receive 100% of their nutritional requirements from such complete nutritional compositions. Partial or incomplete nutritional compositions do not contain all the essential macro and micro nutrients and cannot be used by patients as the sole source of nutrition. Partial or incomplete nutritional compositions can be used as dietary supplements. A nutritional composition specific for a disease or condition is a composition that delivers nutrients or pharmaceuticals, and may be a full or partial nutritional composition.
[0024]本明細書で使用する場合、「約」は、ある数字範囲内の数を指すものと理解されることが好ましい。さらに、本明細書の全ての数値の範囲は、範囲内の全ての整数、又は分数を含むものと理解されたい。 [0024] As used herein, "about" is preferably understood to refer to a number within a numerical range. Further, all numerical ranges herein should be understood to include all integers or fractions within the range.
[0025]本明細書で使用する場合、動物とは、哺乳類を含むが、それに限定されず、その哺乳類は、齧歯類、水生哺乳動物、イヌ及びネコ等の飼育動物、ヒツジ、ブタ、ウシ及びウマ等の家畜、並びにヒトを含むが、これらに限定されない。動物若しくは哺乳類という用語、又はこれらの複数形を使用する場合、当該一節の文脈が示す、又は示すことを意図した効果を実現できる任意の動物にも当てはまると理解されよう。 [0025] As used herein, animals include, but are not limited to, mammals, which include rodents, aquatic mammals, domestic animals such as dogs and cats, sheep, pigs, cows and domestic animals such as horses, as well as including humans, are not limited to. It will be understood that when the term animal or mammal, or a plurality thereof, is used, it applies to any animal that the context of the passage shows or is intended to achieve.
[0026]本明細書で使用する場合、「酸化防止剤」という用語は、活性酸素種(ROS)並びに他のラジカル種及び非ラジカル種によって促進される酸化又は反応を抑制する、任意の1つ又は複数の種々の物質(β−カロテン(ビタミンA前駆体)、ビタミンC、ビタミンE、及びセレン等)を含むものと理解されることが好ましい。さらに、酸化防止剤とは、他の分子の酸化を遅延又は防止できる分子である。本明細書で使用する場合、酸化防止剤の非制限的な例として、カロテノイド、コエンザイムQ10(「CoQ10」)、フラボノイド、グルタチオン、クコ(Goji)(ウルフベリー(Wolfberry))、ヘスペリジン、ラクトウルフベリー(Lactowolfberry)、リグナン、ルテイン、リコペン、ポリフェノール、セレン、ビタミンA、ビタミンB1、ビタミンB6、ビタミンB12、ビタミンC、ビタミンD、ビタミンE、及びこれらの組合せが含まれる。 [0026] As used herein, the term "antioxidant" is any one that inhibits oxidation or reaction promoted by reactive oxygen species (ROS) and other radical and non-radical species. Or it is preferably understood to include a plurality of different substances (β-carotene (vitamin A precursor), vitamin C, vitamin E, selenium, etc.). Furthermore, an antioxidant is a molecule that can retard or prevent oxidation of other molecules. As used herein, non-limiting examples of antioxidants include carotenoids, coenzyme Q10 (“CoQ10”), flavonoids, glutathione, Goji (Wolfberry), hesperidin, lactowolfberry (Lactowolberry), lignan, lutein, lycopene, polyphenol, selenium, vitamin A, vitamin B1, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, and combinations thereof.
[0027]本明細書で使用する場合、「有効量」とは、欠乏を防止する、個体の疾患又は病状を治療する、或いはより一般的には、症状を軽減する、疾患の進行を管理する、又は栄養学的、生理学的若しくは医学的利益を個体にもたらす量であることが好ましい。治療は、患者関連又は医師関連である可能性がある。さらに、「個体」及び「患者」という用語は、本明細書ではヒトを指すために使用されることが多いが、本発明はこれに限定されるものではない。したがって、「個体」及び「患者」という用語は、治療が有益となり得る病状を有するか、その危険性のある任意の動物、哺乳類又はヒトを指すものである。 [0027] As used herein, an "effective amount" refers to managing disease progression, preventing deficiency, treating an individual's disease or condition, or, more generally, reducing symptoms. Or an amount that provides a nutritional, physiological or medical benefit to the individual. Treatment may be patient related or physician related. Furthermore, the terms “individual” and “patient” are often used herein to refer to humans, but the invention is not limited thereto. Thus, the terms “individual” and “patient” are intended to refer to any animal, mammal or human having or at risk for a medical condition in which treatment can be beneficial.
[0028]本明細書で使用する場合、「食品等級微生物」とは、食品に使用され、食品での使用が安全であると通常みなされている微生物を意味する。 [0028] As used herein, "food grade microorganism" means a microorganism that is used in food and is normally considered safe for use in food.
[0029]本明細書で使用する場合、「長期間投与」とは、6週間を超える継続投与であることが好ましい。 [0029] As used herein, "long term administration" is preferably continuous administration for more than 6 weeks.
[0030]本明細書で使用する場合、哺乳類とは、齧歯類、水生哺乳動物、イヌ及びネコ等の飼育動物、ヒツジ、ブタ、ウシ及びウマ等の家畜、並びにヒトを含むが、これらに限定されるものではない。哺乳類という用語を使用する場合、哺乳類が示す、又は示すことを意図した効果を実現できる他の動物にも当てはまると理解されよう。 [0030] As used herein, a mammal refers to rodents, aquatic mammals, domestic animals such as dogs and cats, sheep, pigs, cattle, etc. cattle and horses, as well as including a human, these It is not limited. When the term mammal is used, it will be understood that this also applies to other animals that can achieve the effect that the mammal exhibits or is intended to exhibit.
[0031]「微生物」という用語は、細菌、酵母及び/若しくは真菌、微生物を含む細胞増殖培地、又は微生物が培養された細胞増殖培地を含むことを意図している。 [0031] The term "microorganism" is intended to include bacteria, yeast and / or fungi, cell growth medium containing microorganisms, or cell growth medium in which microorganisms are cultured.
[0032]本発明で使用する場合、「ヌクレオチド」は、デオキシリボ核酸(「DNA」)又はリボ核酸(「RNA」)のサブユニットであると理解されることが好ましい。ヌクレオチドは、窒素塩基、リン酸分子、及び糖分子(DNAではデオキシリボース、及びRNAではリボース)から成る有機化合物である。個々のヌクレオチド単量体(単独ユニット)が結合し合って多量体、すなわち長鎖を形成する。外因性ヌクレオチドは、具体的には栄養素補充によって供給される。外因性ヌクレオチドは、単量体型、例えば、5’−アデノシン一リン酸(「5’−AMP」)、5’−グアノシン一リン酸(「5’−GMP」)、5’−シトシン一リン酸(「5’−CMP」)、5’−ウラシル一リン酸(「5’−UMP」)、5’−イノシン一リン酸(「5’−IMP」)、5’−チミン一リン酸(「5’−TMP」)又はこれらの組合せ等とすることができる。外因性ヌクレオチドは、多量体型、例えば、未処理のRNA等とすることもできる。また、例えば酵母RNA等、多量体型の複数の供給源が存在し得る。 [0032] As used herein, "nucleotide" is preferably understood to be a subunit of deoxyribonucleic acid ("DNA") or ribonucleic acid ("RNA"). Nucleotides are organic compounds composed of nitrogen bases, phosphate molecules, and sugar molecules (deoxyribose for DNA and ribose for RNA). Individual nucleotide monomers (single units) combine to form a multimer, ie, a long chain. Exogenous nucleotides are specifically supplied by nutrient supplementation. Exogenous nucleotides can be monomeric, eg, 5′-adenosine monophosphate (“5′-AMP”), 5′-guanosine monophosphate (“5′-GMP”), 5′-cytosine monophosphate. (“5′-CMP”), 5′-uracil monophosphate (“5′-UMP”), 5′-inosine monophosphate (“5′-IMP”), 5′-thymine monophosphate (“ 5'-TMP ") or combinations thereof. Exogenous nucleotides can also be multimeric, such as untreated RNA. There can also be multiple multimeric sources such as yeast RNA.
[0033]栄養製品は、例えば、1つ又は複数の、ビタミン、ミネラル、糖、薬学的に許容される担体、賦形剤、香味剤、又は着色剤を含む、任意の数の追加成分を更に含むものと理解されることが好ましい。 [0033] The nutritional product further comprises any number of additional ingredients including, for example, one or more vitamins, minerals, sugars, pharmaceutically acceptable carriers, excipients, flavoring agents, or coloring agents. It is preferably understood to include.
[0034]本明細書で使用する場合、「フィトケミカル」又は「フィトニュートリエント」とは、多くの食品に見出される非栄養成分のことである。フィトケミカルは、基本栄養を超える健康上の利益のある機能性食品であり、植物源に由来する健康促進成分である。本明細書で使用する場合、「フィトケミカル」及び「フィトニュートリエント」とは、1つ又は複数の健康上の利益を使用者にもたらす、植物によって生成された任意の化学物質のことを指す。フィトケミカルは、局所、経腸、及び/又は非経口を含む任意の手段で投与することができる。本明細書で使用する場合、フィトケミカル及びフィトニュートリエントの非制限的な例として、以下が含まれる。
1.モノフェノール(アピオール、カルノソール、カルバクロール、ジラピオール、ローズマリノール等);フラボノール(ケルセチン、ギンゲロール、ケンペロール、ミリセチン、ルチン、イソラムネチン等)、フラバノン(ヘスペリジン、ナリンゲニン、シリビン、エリオジクチオール等)、フラボン(アピゲニン、タンゲリチン、ルテオリン等)、フラバン−3−オール(カテキン、(+)−カテキン、(+)−ガロカテキン、(−)−エピカテキン、(−)−エピガロカテキン、(−)−エピガロカテキンガラート(EGCG)、(−)−エピカテキン3−ガラート、テアフラビン、テアフラビン−3−ガラート、テアフラビン−3’−ガラート、テアフラビン−3,3’−ジガラート、テアルビギン等)、アントシアニン(フラボナール)及びアントシアニジン(ペラルゴニジン、ペオニジン、シアニジン、デルフィニジン、マルビジン、ペツニジン等)、イソフラボン(フィトエストロゲン)(ダイゼイン(ホルモノネチン)、ゲニステイン(ビオカニンA)、グリシテイン等)、ジヒドロフラボノール、カルコン、クメスタン(フィトエストロゲン)並びにクメストロールを含むフラボノイド(ポリフェノール);フェノール酸(エラグ酸、没食子酸、タンニン酸、バニリン、クルクミン等);ヒドロキシケイ皮酸(カフェー酸、クロロゲン酸、ケイ皮酸、フェルラ酸、クマリン等);リグナン(フィトエストロゲン)、シリマリン、セコイソラリシレシノール、ピノレシノール及びラリシレシノール;チロソールエステル(チロソール、ヒドロキシチロソール、オレオカンタール、オロイロペイン等);スチルベノイド(レスベラトロール、プテロスチルベン、ピセアタンノール等)及びプニカラギン;を含むフェノール化合物、
2.カロテン(α−カロテン、β−カロテン、γ−カロテン、δ−カロテン、リコペン、ノイロスポレン、フィトフルエン、フィトエン等)及びキサントフィル(カンタキサンチン、クリプトキサンチン、ゼアキサンチン、アスタキサンチン、ルテイン、ルビキサンチン等)を含むカロテノイド(テトラテルペノイド);モノテルペン(リモネン、ペリリルアルコール等);サポニン;フィトステロール(カンペステロール、β−シトステロール、γ−シトステロール、スチグマステロール等)、トコフェロール(ビタミンE)、並びにω−3、6、及び9脂肪酸(γ−リノレン酸等)を含む脂質;トリテルペノイド(オレアノール酸、ウルソール酸、ベツリン酸、モロン酸等);を含むテルペン(イソプレノイド)、
3.ベタシアニン(ベタニン、イソベタニン、プロベタニン、ネオベタニン等)及びベタキサンチン(非グリコシド型)(インジカキサンチン及びブルガキサンチン等)を含むベタレイン、
4.ジチオールチオン(イソチオシアナート)(スルホラファン等)及びチオスルホナート(ネギ類由来の化合物)(アリルメチルトリスルフィド及びジアリルスルフィド等)を含むオルガノスルフィド、インドール、グルコシノラート(これらは、インドール−3−カルビノール、スルホラファン、3,3’−ジインドリルメタン、シニグリン、アリシン、アリイン、アリルイソチオシアナート、ピペリン、Syn−プロパンチアール−S−オキシドを含む)、
5.プロテアーゼ阻害剤を含むタンパク質阻害剤、
6.シュウ酸、フィチン酸(イノシトール六リン酸)、酒石酸、及びアナカルド酸を含む他の有機酸、並びに
7.これらの組合せ。
[0034] As used herein, "phytochemical" or "phytonutrient" refers to a non-nutritive ingredient found in many foods. Phytochemicals are functional foods with health benefits that exceed basic nutrition and are health promoting ingredients derived from plant sources. As used herein, “phytochemical” and “phytonutrient” refer to any chemical produced by a plant that provides a user with one or more health benefits. The phytochemical can be administered by any means including topical, enteral, and / or parenteral. As used herein, non-limiting examples of phytochemicals and phytonutrients include the following.
1. Monophenol (Apiol, Carnosol, Carvacrol, Dirapiol, Rosemarinol, etc.); Flavonol (Quercetin, Gingerol, Kaempferol, Myricetin, Rutin, Isoramnetin, etc.), Flavanone (Hesperidin, Naringenin, Silybin, Eriodictyol etc.), Flavon (Apigenin) , Tangerine, luteolin, etc.), flavan-3-ol (catechin, (+)-catechin, (+)-gallocatechin, (−)-epicatechin, (−)-epigallocatechin, (−)-epigallocatechinga Rato (EGCG), (−)-epicatechin 3-gallate, theaflavin, theaflavin-3-gallate, theaflavin-3′-gallate, theaflavin-3,3′-digallate, thealbigin, etc.), anthocyanins (flavonals) And anthocyanidins (pelargonidin, peonidin, cyanidin, delphinidin, malvidin, petunidin, etc.), isoflavones (phytoestrogens) (daidzein (formononetin), genistein (biocanin A), glycitein, etc.), dihydroflavonols, chalcones, cumestanes (phytoestrogens) Flavonoids (polyphenols) containing strols; phenolic acids (ellagic acid, gallic acid, tannic acid, vanillin, curcumin, etc.); hydroxycinnamic acids (caffeic acid, chlorogenic acid, cinnamic acid, ferulic acid, coumarins, etc.); lignans ( Phytoestrogens), silymarin, secoisolariciresinol, pinoresinol and lariciresinol; tyrosol esters (tyrosol, hydroxytyrosol, oleocan) Tar, ololopain, etc.); stilbenoids (resveratrol, pterostilbene, piceatannol, etc.) and punicalagins;
2. Carotenoids including carotenes (α-carotene, β-carotene, γ-carotene, δ-carotene, lycopene, neurosporene, phytofluene, phytoene, etc.) and xanthophylls (canthaxanthin, cryptoxanthine, zeaxanthin, astaxanthin, lutein, rubixanthine, etc.) (Tetraterpenoids); monoterpenes (limonene, perillyl alcohol, etc.); saponins; phytosterols (campesterol, β-sitosterol, γ-sitosterol, stigmasterol, etc.), tocopherols (vitamin E), and ω-3, 6, And terpenes (isoprenoids) containing triterpenoids (oleanolic acid, ursolic acid, betulinic acid, molonic acid, etc.); and lipids containing 9 fatty acids (γ-linolenic acid, etc.),
3. Betalain including betacyanin (betanin, isobetanin, probetanin, neobetanin, etc.) and betaxanthine (non-glycoside type) (indicaxanthin, bulgaxanthin, etc.),
4). Organosulfides, indoles, glucosinolates (including indole-3), including dithiolthiones (isothiocyanates) (sulforaphanes, etc.) and thiosulfonates (compounds derived from leeks) (allylmethyl trisulfide and diallyl sulfide, etc.) -Including carbinol, sulforaphane, 3,3'-diindolylmethane, sinigrine, allicin, alliin, allyl isothiocyanate, piperine, Syn-propanethiar-S-oxide)
5. Protein inhibitors, including protease inhibitors,
6). 6. Other organic acids including oxalic acid, phytic acid (inositol hexaphosphate), tartaric acid, and anacardic acid; A combination of these.
[0035]本明細書及び添付の特許請求の範囲で使用する場合、単数形の「a」、「an」及び「the」は、文脈上明確に否定されない限り、複数の指示対象を含む。したがって、例えば、「ポリペプチド」の指示対象は2個以上のポリペプチドの混合物を含む。 [0035] As used herein and in the appended claims, the singular forms “a”, “an”, and “the” include plural referents unless the context clearly dictates otherwise. Thus, for example, a reference object of “polypeptide” includes a mixture of two or more polypeptides.
[0036]本明細書で使用する場合、「プレバイオティクス」は、腸内で選択的に、有益細菌の増殖を促進、又は病原細菌の増殖を抑制する食用物質であることが好ましい。プレバイオティクスは、胃及び/又は腸上部の中で不活化されず、摂取する人の胃腸管の中で吸収もされないが、胃腸内微生物叢及び/又はプロバイオティクスによって発酵される。プレバイオティクスは、例えば、Glenn R.Gibson及びMarcel B.Roberfroid,Dietary Modulation of the Human Colonic Microbiota:Introducing the Concept of Prebiotics,J.Nutr.1995 125:1401〜1412ページによって定義されている。 [0036] As used herein, "prebiotics" are preferably edible substances that selectively promote the growth of beneficial bacteria or inhibit the growth of pathogenic bacteria in the intestine. Prebiotics are not inactivated in the stomach and / or upper intestine and are not absorbed in the gastrointestinal tract of the ingesting person, but are fermented by the gastrointestinal microflora and / or probiotics. Prebiotics are described, for example, in Glenn R. et al. Gibson and Marcel B.M. Robert Fluid, Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics, J. MoI. Nutr. 1995 125: 1401-1412.
[0037]本明細書で使用する場合、プロバイオティクス微生物(以下「プロバイオティクス」)とは、適量を投与された場合、宿主に健康上の利益をもたらし得る、より具体的には、腸内微生物バランスを改善することによって、宿主に有益に作用し、宿主の健康又は幸福に効果をもたらすような、微生物(半生存可能若しくは弱体化、及び/又は非複製を含む生存状態)、代謝物、微生物細胞調製物、又は微生物細胞の構成成分であることが好ましい(Salminen S,Ouwehand, A.Benno Y.ら「Probiotics:how should they be defined」Trends Food Sci.Technol.1999:10 107〜10ページ)。一般的に、これらの微生物は、腸管内の病原細菌の増殖及び/又は代謝を抑制するか、これらに影響を与えるものと考えられている。プロバイオティクスは、宿主の免疫機能を活性化することもある。このため、プロバイオティクスを食品に含ませる多くの様々なアプローチが成されてきた。 [0037] As used herein, probiotic microorganisms (hereinafter "probiotics") are those that can provide a health benefit to a host when administered in an appropriate amount, more specifically, intestinal Microorganisms (live states including semi-viable or weakened and / or non-replicating), metabolites that beneficially affect the host and improve the health or well-being of the host by improving the internal microbial balance , A microbial cell preparation, or a constituent of a microbial cell (Salminen S, Ouwehand, A. Benno Y. et al. “Probiotics: how shoulder the defined” Trends Food Sci. Technol. page). In general, these microorganisms are thought to inhibit or affect the growth and / or metabolism of pathogenic bacteria in the intestinal tract. Probiotics may activate the immune function of the host. For this reason, many different approaches have been made to include probiotics in food.
[0038]本明細書で使用する「タンパク質」、「ペプチド」、「オリゴペプチド」又は「ポリペプチド」という用語は、1個のアミノ酸(単量体)、ペプチド結合によって結合した2個以上のアミノ酸(ジペプチド、トリペプチド、又はポリペプチド)、前駆体、相同体、類似体、模倣物、塩、プロドラッグ、代謝物、又はこれらのフラグメント若しくは組合せを含む、任意の組成物を指すものと理解されることが好ましい。明確にするために、特に指定がない限り、上記の用語のいずれも交換可能に使用することができる。ポリペプチド(又はペプチド若しくはタンパク質又はオリゴペプチド)は、一般に20種の天然アミノ酸と呼ばれる20種のアミノ酸以外のアミノ酸を含有することが多く、末端アミノ酸を含む多くのアミノ酸が、グリコシル化及び他の翻訳後修飾等の自然過程、又は当技術分野において周知の化学修飾技術のいずれかによって、所与のポリペプチド中で修飾され得ることが理解されよう。本発明のポリペプチドの中で起こり得る公知の修飾には、アセチル化、アシル化、ADP−リボシル化、アミド化、フラバノイド又はヘム部分の共有結合、ポリヌクレオチド又はポリヌクレオチド誘導体の共有結合、脂質又は脂質誘導体の共有結合、ホスファチジルイノシトールの共有結合、架橋結合、環化、ジスルフィド結合形成、脱メチル化、共有結合架橋の形成、シスチンの形成、ピログルタミン酸の形成、ホルミル化、γ−カルボキシル化、糖化、グリコシル化、グリコシルホスファチジルイノシトール(GPI)膜アンカー形成、ヒドロキシル化、ヨウ素化、メチル化、ミリストイル化、酸化、タンパク質分解プロセシング、リン酸化、プレニル化、ラセミ化、セレノイル化(selenoylation)、硫酸化、アルギニル化等のポリペプチドへの転移RNAによるアミノ酸の付加、及びユビキチン化が含まれるが、これらに限定されるものではない。「タンパク質」という用語は、ペプチドの交互反復配列から成る線状又は非線状のポリペプチドを指す「人工タンパク質」も含む。 [0038] As used herein, the terms "protein", "peptide", "oligopeptide" or "polypeptide" refer to one amino acid (monomer), two or more amino acids joined by peptide bonds. (Dipeptides, tripeptides or polypeptides) are understood to refer to any composition, including precursors, homologues, analogs, mimetics, salts, prodrugs, metabolites, or fragments or combinations thereof. It is preferable. For clarity, any of the above terms can be used interchangeably unless otherwise specified. Polypeptides (or peptides or proteins or oligopeptides) often contain amino acids other than the 20 amino acids commonly referred to as the 20 natural amino acids, and many amino acids, including terminal amino acids, are glycosylated and other translations. It will be appreciated that modifications can be made in a given polypeptide by either natural processes, such as post-modification, or chemical modification techniques well known in the art. Known modifications that can occur in the polypeptides of the invention include acetylation, acylation, ADP-ribosylation, amidation, covalent attachment of flavonoid or heme moieties, covalent attachment of polynucleotides or polynucleotide derivatives, lipids or Covalent bonding of lipid derivatives, covalent bonding of phosphatidylinositol, cross-linking, cyclization, disulfide bond formation, demethylation, formation of covalent cross-links, formation of cystine, formation of pyroglutamic acid, formylation, γ-carboxylation, glycation Glycosylation, glycosylphosphatidylinositol (GPI) membrane anchoring, hydroxylation, iodination, methylation, myristoylation, oxidation, proteolytic processing, phosphorylation, prenylation, racemization, selenoylation, sulfation, Arginyl The addition of amino acids by transfer RNA to a polypeptide etc, and ubiqutination, but is not limited thereto. The term “protein” also includes “artificial proteins” that refer to linear or non-linear polypeptides consisting of alternating sequences of peptides.
[0039]本出願の中に包含される全ての投与量の範囲は、前記範囲の中に包含される整数又は分数の全ての数字を含むことを意図している。 [0039] All dosage ranges encompassed within this application are intended to include all integer or fractional numbers subsumed within said range.
[0040]本明細書で使用する場合、「短期投与」とは、6週間未満の継続投与であることが好ましい。 [0040] As used herein, "short term administration" is preferably continuous administration for less than 6 weeks.
[0041]本明細書で使用する場合、シンバイオティクスとは、共同して腸の微生物叢を改善するプレバイオティクス及びプロバイオティクスの両方を包含するサプリメントである。 [0041] As used herein, synbiotics are supplements that include both prebiotics and probiotics that jointly improve the gut microbiota.
[0042]本明細書で使用する場合、「治療」(treatment)、「治療する」(treat)及び「緩和する」という用語は、予防(prophylactic)又は予防治療(preventive treatment)(対象とする病的状態又は障害の進行を防止する、及び/又は遅らせる)、及び診断を受けた病的状態又は障害の症状を治癒する、遅らせる、症状を軽減する、及び/又は、その進行を止める治療措置を含む、治癒的治療、治療又は病態修飾治療の双方と、疾患に罹患する危険性があるか、疾患に罹患した疑いのある患者、及び病気であるか、疾患若しくは病状に罹患していると診断された患者の治療とに、好ましくは向けられる。「治療」及び「治療する」という用語は、疾患に罹患してはいないが、窒素平衡の失調又は筋肉の減少等の不健康な状態になりやすい可能性のある個体の健康の維持及び/又は促進も指す。「治療」、「治療する」及び「緩和する」という用語は、1つ又は複数の一次予防措置又は一次治療措置の増強又は強化を含むことも意図している。 [0042] As used herein, the terms "treatment", "treat" and "relieve" refer to prophylactic or preventive treatment (target disease) Preventive and / or delay the progression of the symptom or disorder) and cure the symptoms of the pathological condition or disorder that has been diagnosed, delay, alleviate the symptoms, and / or stop the progression Including both curative treatments, treatments or pathologic modification treatments, and patients at risk of or suspected of having the disease, and diagnosed as being ill or suffering from the disease or condition Preferably directed to the treatment of treated patients. The terms “treatment” and “treating” refer to maintaining and / or promoting the health of an individual who is not afflicted with a disease but may be prone to unhealthy conditions such as a loss of nitrogen balance or muscle loss. Also refers to. The terms “treatment”, “treating” and “relieving” are also intended to include augmentation or enhancement of one or more primary preventive or primary therapeutic measures.
[0043]本明細書で使用する場合、「経管栄養」は、経口投与経由以外の動物の胃腸系に投与される完全型又は不完全型の栄養製品であることが好ましく、経鼻胃管、経口胃管、胃管、空腸瘻管(J管)、経皮内視鏡下胃瘻造設術(PEG)、胃、空腸に到達できる胸壁ポート等のポート及び他の好適なアクセスポートを含むポート等を包含するが、これらに限定されるものではない。 [0043] As used herein, "tube feeding" is preferably a complete or incomplete nutritional product that is administered to the gastrointestinal system of an animal other than via oral administration. Oral gastric tube, gastric tube, jejunostomy tube (J tube), percutaneous endoscopic gastrostomy (PEG), stomach, port such as chest wall port that can reach the jejunum and other suitable access ports, etc. However, it is not limited to these.
[0044]本明細書で使用する場合、「ビタミン」という用語は、身体の正常な成長及び活動のために微量で必須であり、植物性及び動物性の食品から自然に得られる、又は合成で作られる種々の脂溶性又は水溶性の有機物(非制限的な例として、ビタミンA、ビタミンB1、ビタミンB6、ビタミンB12、ビタミンC、ビタミンD、ビタミンEが含まれる)、プロビタミン、誘導体、類似体のいずれも含むものと理解されることが好ましい。 [0044] As used herein, the term "vitamin" is essential in trace amounts for the normal growth and activity of the body and is naturally derived from plant and animal foods or synthetically. Various fat-soluble or water-soluble organics made (including but not limited to vitamin A, vitamin B1, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E), provitamins, derivatives, similar It is preferred to be understood to include any body.
[0045]本明細書で使用する場合、「腸機能障害」という用語は以下を含む。
a.消化不良−大部分の医師が胃十二指腸部位から生じると考えているある症状又は一連の症状。具体的な症状は、食後の膨満感、早期飽満感、上腹部での腹部膨満、心窩部の痛み又は胸やけ、嘔気、嘔吐及びおくびである。診断するには1つ又は複数の症状が必要である。
b.過敏性腸症候群−腹部の痛み又は不快感が、排便、又は排便習慣の変化に関連し、排便が不規則になる特徴を伴う障害。
c.機能性腹痛症候群−「慢性突発性腹痛」及び「慢性機能性腹痛」とも呼ばれ、腸機能との関連が薄く、日常活動を幾分妨げる、少なくとも6か月間続く、腹部に起因する痛みのことである。痛みは持続的、ほぼ持続的、又は少なくとも再発が頻繁である。
d.機能性肛門直腸障害−以下のように細分される。
i.機能性大便失禁−少なくとも3か月間再発を繰り返す糞便物質の制御不能な排出。不随意な排ガスもある。
ii.機能性肛門直腸痛−慢性直腸神経痛及び一過性直腸神経痛の2つの形態がある。
1.慢性直腸神経痛−肛門挙筋症候群、挙筋痙攣、恥骨直腸筋症候群、梨状筋症候群、及び骨盤緊張筋肉痛とも呼ばれる。痛みはぼんやりした鈍い痛み、又は直腸内の強い圧覚である。
2.一過性直腸神経痛−数秒〜30分もの間持続し、その後完全に消失する肛門部の突発性の激痛。痛みはほとんどの場合(症例の90%)局在的であり低頻度である。
e.機能性排便障害−緩慢な結腸通過又は排出の遅延。奇異性収縮、又は骨盤底筋の不適切な弛緩、若しくは排便を試みる際の不適切な推進力によって特徴付けられる。過剰ないきみ、残便感、及び指を使って排便を助けることを伴う。
[0045] As used herein, the term "intestinal dysfunction" includes:
a. Indigestion-A symptom or series of symptoms that most physicians believe to arise from the gastroduodenal site. Specific symptoms are postprandial bloating, premature satiety, abdominal bloating in the upper abdomen, epigastric pain or heartburn, nausea, vomiting and snoring. Diagnosis requires one or more symptoms.
b. Irritable bowel syndrome-a disorder with features that abdominal pain or discomfort is associated with bowel movements or changes in bowel habits, making bowel movements irregular.
c. Functional abdominal pain syndrome-also called "chronic sudden abdominal pain" and "chronic functional abdominal pain", pain associated with the abdomen that lasts for at least 6 months and is less related to bowel function and somewhat interferes with daily activities It is. Pain is persistent, nearly persistent, or at least frequent recurrence.
d. Functional anorectal disorder-subdivided as follows:
i. Functional fecal incontinence-uncontrollable excretion of fecal material that recurs for at least 3 months. There are also involuntary exhaust gases.
ii. There are two forms of functional anorectal pain-chronic rectal neuralgia and transient rectal neuralgia.
1. Chronic rectal neuralgia—also called levator ani syndrome, levator convulsions, pubic rectal muscle syndrome, piriformis syndrome, and pelvic tension myalgia. Pain is a dull, dull pain or a strong pressure in the rectum.
2. Transient rectal neuralgia-sudden severe pain in the anus that lasts for a few seconds to 30 minutes and then disappears completely. Pain is most often (90% of cases) localized and infrequent.
e. Functional defecation disorder-slow colon transit or delayed elimination. Characterized by odd heterogeneous contraction, or inappropriate relaxation of the pelvic floor muscles, or inappropriate propulsion when attempting defecation. With excessive creaking, feeling of residual stool, and helping defecation with fingers.
[0046]外因性ヌクレオチドは、機能及び構造の修復及び維持のために他の成分と組み合わせることができる。例えば、外因性ヌクレオチドは、アミノ酸(例えばロイシン)、炎症を和らげるための脂質(低いn6:n3)、生理活性ペプチド、プロテアーゼ阻害剤、クレアチン等の他の特定の食品構成成分と組み合わせて使用した場合、より効果的に働いて骨格筋の修復、維持、及び改善を補助し得る可能性がある。 [0046] Exogenous nucleotides can be combined with other components for the repair and maintenance of function and structure. For example, exogenous nucleotides are used in combination with other specific food components such as amino acids (eg leucine), lipids to reduce inflammation (low n6: n3), bioactive peptides, protease inhibitors, creatine, etc. May work more effectively to help repair, maintain, and improve skeletal muscle.
[0047]一実施形態では、栄養組成物は、1つ又は複数のプレバイオティクスを更に含む。プレバイオティクスの非制限的な例として、フラクトオリゴ糖、イヌリン、ラクツロース、ガラクトオリゴ糖、アカシアゴム、大豆オリゴ糖、キシロオリゴ糖、イソマルトオリゴ糖、ゲンチオオリゴ糖、ラクトスクロース、グルコオリゴ糖、ペクチンオリゴ糖、難消化性デンプン、糖アルコール又はこれらの組合せが含まれる。 [0047] In one embodiment, the nutritional composition further comprises one or more prebiotics. Non-limiting examples of prebiotics include fructooligosaccharide, inulin, lactulose, galactooligosaccharide, acacia gum, soybean oligosaccharide, xylooligosaccharide, isomaltoligosaccharide, gentio-oligosaccharide, lactosucrose, gluco-oligosaccharide, pectin oligosaccharide, indigestible Sex starch, sugar alcohols or combinations thereof.
[0048]一実施形態では、栄養組成物は1つ又は複数のプロバイオティクスを更に含む。本明細書で使用する場合、プロバイオティクスとは、適量を投与された場合、宿主に健康上の利益をもたらし得る可能性がある微生物(例えば、生存状態、増殖及び複製能力を減じた状態、又は非複製状態)と定義される。プロバイオティクスの非制限的な例として、アカシアゴム、αグルカン、βグルカン、フラクトオリゴ糖、ガラクトオリゴ糖、ゲンチオオリゴ糖、グルコオリゴ糖、グアーガム、イヌリン、イソマルトオリゴ糖、ラクトスクロース、ラクツロース、部分加水分解グアーガム、ペクチンオリゴ糖、大豆オリゴ糖、糖アルコール、キシロオリゴ糖、又はこれらの組合せが含まれる。 [0048] In one embodiment, the nutritional composition further comprises one or more probiotics. As used herein, probiotics are microorganisms (eg, those that have reduced viability, growth and replication potential) that, when administered in an appropriate amount, may provide a health benefit to the host. Or non-replicated state). Non-limiting examples of probiotics include acacia gum, α-glucan, β-glucan, fructooligosaccharide, galactooligosaccharide, gentio-oligosaccharide, gluco-oligosaccharide, guar gum, inulin, isomaltoligosaccharide, lactosucrose, lactulose, partially hydrolyzed guar gum, Pectin oligosaccharides, soybean oligosaccharides, sugar alcohols, xylo-oligosaccharides, or combinations thereof are included.
[0049]別の実施形態では、栄養組成物は、1種又は複数のアミノ酸を更に含む。アミノ酸の非制限的な例として、アラニン、アルギニン、アスパラギン、アスパラギン酸、システイン、グルタミン酸、グルタミン、グリシン、ヒスチジン、イソロイシン、ロイシン、リシン、メチオニン、フェニルアラニン、プロリン、セリン、スレオニン、トリプトファン、チロシン、及びバリン、又はこれらの組合せが含まれる。アミノ酸には、胃腸管での有益な効果をもたらすものがあり、例えば、スレオニンはムチンの生成に役割を果たし、また、グルタミン、グリシン、及びシステインはグルタチオンの生成に役割を果たす。 [0049] In another embodiment, the nutritional composition further comprises one or more amino acids. Non-limiting examples of amino acids include alanine, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, and valine. Or combinations thereof. Some amino acids have a beneficial effect in the gastrointestinal tract, for example, threonine plays a role in mucin production, and glutamine, glycine, and cysteine play a role in the production of glutathione.
[0050]一実施形態では、栄養組成物は、1つ又は複数のシンバイオティクス、魚油、フィトニュートリエント、及び/又は酸化防止剤を更に含む。本明細書で使用する場合、シンバイオティクスとは、共同して腸の微生物叢を改善するプレバイオティクス及びプロバイオティクスの両方を包含するサプリメントである。魚油の非制限的な例として、ドコサヘキサエン酸(「DHA」)及びエイコサペンタエン酸(「EPA」)が含まれる。ドコサヘキサエン酸(「DHA」)及び/又はエイコサペンタエン酸(「EPA」)は、非魚油源にも存在することがある。フィトニュートリエントの非制限的な例として、クルクミン、リモニン、及びケルセチンを含む、フラボノイド並びに関連のフェノール及びポリフェノール化合物、カロテノイド等のテルペノイド、及びアルカロイドであるものが含まれる。 [0050] In one embodiment, the nutritional composition further comprises one or more symbiotics, fish oil, phytonutrients, and / or antioxidants. As used herein, synbiotics are supplements that include both prebiotics and probiotics that together improve the gut microbiota. Non-limiting examples of fish oils include docosahexaenoic acid (“DHA”) and eicosapentaenoic acid (“EPA”). Docosahexaenoic acid ("DHA") and / or eicosapentaenoic acid ("EPA") may also be present in non-fish oil sources. Non-limiting examples of phytonutrients include those that are flavonoids and related phenol and polyphenol compounds, terpenoids such as carotenoids, and alkaloids, including curcumin, limonin, and quercetin.
[0051]本開示は、別の実施形態において、栄養組成物を作製する方法を提供する。かかる方法は、テアニン及び1種又は複数の外因性ヌクレオチドを、例えば、哺乳類の病的状態の治療又は健康の向上のために有効な量で、栄養組成物に添加するステップを含む。栄養組成物は、医薬製剤、栄養製剤、健康補助食品、機能性食品、飲料製品、又はこれらの組合せ等の投与可能な形態とすることができる。 [0051] The present disclosure, in another embodiment, provides a method of making a nutritional composition. Such methods include the step of adding theanine and one or more exogenous nucleotides to the nutritional composition, for example, in an amount effective for treating a mammal's pathological condition or improving health. The nutritional composition can be in an administrable form such as a pharmaceutical preparation, a nutritional preparation, a health supplement, a functional food, a beverage product, or a combination thereof.
[0052]本開示は、他の実施形態において、個体(例えば、ヒト、患者)又は哺乳動物(例えば、ペット、動物)の過敏性腸症候群を治療する方法を提供する。かかる方法は、過敏性腸症候群に罹患している個体又は哺乳類に、有効な量の、テアニン及び1種又は複数の外因性ヌクレオチドを含む栄養組成物を投与するステップを含む。例えば、栄養組成物は、投与されようとする量が約100mg/日〜約600mg/日、好ましくは100mg/日〜約400mg/日、好ましくは150mg/日〜約400mg/日、好ましくは200mg/日〜約300mg/日の範囲で、テアニンを含んでもよい。 [0052] The present disclosure, in other embodiments, provides a method of treating irritable bowel syndrome in an individual (eg, human, patient) or mammal (eg, pet, animal). Such a method comprises administering to an individual or mammal suffering from irritable bowel syndrome an effective amount of a nutritional composition comprising theanine and one or more exogenous nucleotides. For example, the nutritional composition may be administered in an amount from about 100 mg / day to about 600 mg / day, preferably from 100 mg / day to about 400 mg / day, preferably from 150 mg / day to about 400 mg / day, preferably 200 mg / day. Theanine may be included in the range of days to about 300 mg / day.
[0053]栄養組成物は、投与されようとする量が約200mg/日〜約6g/日、好ましくは500mg/日〜4g/日、好ましくは750mg/日〜3.5g/日、又は好ましくは1g/日〜3g/日の範囲で、外因性ヌクレオチドを含んでもよい。 [0053] The nutritional composition may be administered in an amount from about 200 mg / day to about 6 g / day, preferably 500 mg / day to 4 g / day, preferably 750 mg / day to 3.5 g / day, or preferably Exogenous nucleotides may be included in the range of 1 g / day to 3 g / day.
[0054]栄養組成物を充分美味にするために、他の任意選択の成分が添加されてもよい。任意選択の成分は、任意の適量で添加することができる。例えば、任意選択の成分である部分加水分解グアーガムは、約3g/日〜約15g/日、好ましくは4g/日〜12g/日、好ましくは5g/日〜10g/日のレベルで投与することができる。 [0054] Other optional ingredients may be added to make the nutritional composition sufficiently tasty. Optional ingredients can be added in any suitable amount. For example, the optionally hydrolyzed partially hydrolyzed guar gum may be administered at a level of about 3 g / day to about 15 g / day, preferably 4 g / day to 12 g / day, preferably 5 g / day to 10 g / day. it can.
[0055]本明細書に記載した現在好ましい実施形態の種々の変更及び改変が、当業者には明らかと見込まれることは理解されたい。かかる変更及び改変は、現在の主題の趣旨及び範囲から逸脱することもなく、意図するその利点を損なうこともなく、なすことができる。したがって、かかる変更及び改変は添付の特許請求の範囲によって包含されることを意図するものである。 [0055] It should be understood that various changes and modifications to the presently preferred embodiments described herein will be apparent to those skilled in the art. Such changes and modifications can be made without departing from the spirit and scope of the present subject matter and without diminishing its intended advantages. Accordingly, such changes and modifications are intended to be encompassed by the appended claims.
Claims (23)
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CN105687225B (en) * | 2016-02-26 | 2018-07-06 | 四川好医生攀西药业有限责任公司 | A kind of pharmaceutical composition for treating irritable bowel syndrome and its preparation method and application |
CN105902558B (en) * | 2016-03-15 | 2018-07-06 | 四川好医生攀西药业有限责任公司 | A kind of pharmaceutical composition and its preparation method and application |
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Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06169642A (en) * | 1991-04-30 | 1994-06-21 | Yokoyama Tsunetaka | Production of promoter of flavor enhancement, cell diviion and thickening of plant and its usage |
JP2005056022A (en) * | 2003-06-12 | 2005-03-03 | Toshiba Corp | Data extraction apparatus, data extraction method and data extraction program |
JP2005206462A (en) * | 2004-01-19 | 2005-08-04 | Taiyo Kagaku Co Ltd | Composition for mitigating or eliminating anxiety disorder |
JP2006522766A (en) * | 2003-04-08 | 2006-10-05 | ノバルティス アクチエンゲゼルシャフト | Symbiotic combination |
JP2008115185A (en) * | 2004-09-17 | 2008-05-22 | Ajinomoto Co Inc | Agent and food for preventing/improving functional gastrointestinal disorder |
WO2009070378A1 (en) * | 2007-11-26 | 2009-06-04 | Nestec S.A. | Compositions and methods for inhibiting the activation of dsrna-dependent protein kinase and tumor growth inhibition |
JP2010057483A (en) * | 2008-08-07 | 2010-03-18 | Taiyo Kagaku Co Ltd | Visceral hypersensitivity-improving food |
JP2012502996A (en) * | 2008-09-19 | 2012-02-02 | ネステク ソシエテ アノニム | Nutritional support of the immune system during anticancer treatment |
JP2012502998A (en) * | 2008-09-19 | 2012-02-02 | ネステク ソシエテ アノニム | Nutritional support to prevent or reduce myelotoxicity from cancerous tumors |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2548899A (en) * | 1998-02-23 | 1999-09-06 | Taiyo Kagaku Co. Ltd. | Composition comprising theanine |
US20040001817A1 (en) * | 2002-05-14 | 2004-01-01 | Giampapa Vincent C. | Anti-aging nutritional supplement |
AU2003295777A1 (en) * | 2002-11-21 | 2004-06-18 | Dss Global, Inc. | Nucleotide based medicament and method of use for treatment of conditions in humans |
JP2006273765A (en) * | 2005-03-30 | 2006-10-12 | Gotoo Corporation:Kk | Constipation ameliorator, use thereof, fecal odor ameliorator, and use thereof |
EP1895992A4 (en) * | 2005-05-23 | 2012-03-28 | Kraft Foods Global Brands Llc | Compressible gum based delivery systems for the release of ingredients |
US20070218170A1 (en) * | 2006-03-03 | 2007-09-20 | Health Beverage Llc | Fiber Containing Alkaline Beverage and Methods For Production Thereof |
TW200822930A (en) * | 2006-11-22 | 2008-06-01 | Chao-Song Hsue | Composition for reducing weight and curing hypertriglyceridemia, the effective ingredients thereof containing cyclic AMP, nicotinic acid, prostaglandin, gamma linolenic acid, and xanthine derivates |
US20080153927A1 (en) * | 2006-12-22 | 2008-06-26 | Allergan, Inc. | Alpha-2b receptor agonist and relaxant compositions for treating gastrointestinal motility disorders |
CN101133768A (en) * | 2007-07-26 | 2008-03-05 | 马庆发 | Nucleic acid tea |
KR20090085870A (en) * | 2008-02-05 | 2009-08-10 | 이팔성 | Method for preparing a composition for seasoning for puffer fish soup |
US8642095B2 (en) * | 2008-09-30 | 2014-02-04 | Visalus Holdings, Llc | Dietary composition and method of using the same |
-
2010
- 2010-08-23 CN CN2010800427685A patent/CN102595936A/en active Pending
- 2010-08-23 EP EP10748190A patent/EP2480098A2/en not_active Withdrawn
- 2010-08-23 JP JP2012530892A patent/JP2013505720A/en active Pending
- 2010-08-23 AU AU2010298640A patent/AU2010298640A1/en not_active Abandoned
- 2010-08-23 US US13/497,403 patent/US20120270830A1/en not_active Abandoned
- 2010-08-23 CA CA2775059A patent/CA2775059A1/en not_active Abandoned
- 2010-08-23 BR BRBR112012007418-0A patent/BR112012007418A2/en not_active IP Right Cessation
- 2010-08-23 WO PCT/US2010/046301 patent/WO2011037712A2/en active Application Filing
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06169642A (en) * | 1991-04-30 | 1994-06-21 | Yokoyama Tsunetaka | Production of promoter of flavor enhancement, cell diviion and thickening of plant and its usage |
JP2006522766A (en) * | 2003-04-08 | 2006-10-05 | ノバルティス アクチエンゲゼルシャフト | Symbiotic combination |
JP2005056022A (en) * | 2003-06-12 | 2005-03-03 | Toshiba Corp | Data extraction apparatus, data extraction method and data extraction program |
JP2005206462A (en) * | 2004-01-19 | 2005-08-04 | Taiyo Kagaku Co Ltd | Composition for mitigating or eliminating anxiety disorder |
JP2008115185A (en) * | 2004-09-17 | 2008-05-22 | Ajinomoto Co Inc | Agent and food for preventing/improving functional gastrointestinal disorder |
WO2009070378A1 (en) * | 2007-11-26 | 2009-06-04 | Nestec S.A. | Compositions and methods for inhibiting the activation of dsrna-dependent protein kinase and tumor growth inhibition |
JP2010057483A (en) * | 2008-08-07 | 2010-03-18 | Taiyo Kagaku Co Ltd | Visceral hypersensitivity-improving food |
JP2012502996A (en) * | 2008-09-19 | 2012-02-02 | ネステク ソシエテ アノニム | Nutritional support of the immune system during anticancer treatment |
JP2012502997A (en) * | 2008-09-19 | 2012-02-02 | ネステク ソシエテ アノニム | Nutritional support to prevent or alleviate bone marrow paralysis or neutropenia during anticancer treatment |
JP2012502998A (en) * | 2008-09-19 | 2012-02-02 | ネステク ソシエテ アノニム | Nutritional support to prevent or reduce myelotoxicity from cancerous tumors |
Non-Patent Citations (1)
Title |
---|
MRUKAWA M: "L-THEANINE ELICITS AN UMAMI TASTE WITH INOSINE 5'-MONOPHOSPHATE", BIOSCIENCE, BIOTECHNOLOGY AND BIOCHEMISTRY, vol. V72 N11, JPN5012018245, 27 March 2008 (2008-03-27), pages 3015 - 3017, ISSN: 0002753239 * |
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