JP2013122073A - Thin film forming apparatus - Google Patents
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- 239000010409 thin film Substances 0.000 title claims abstract description 56
- 239000000919 ceramic Substances 0.000 claims abstract description 8
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 21
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 21
- 239000000203 mixture Substances 0.000 claims description 10
- 239000001506 calcium phosphate Substances 0.000 claims description 9
- 238000001816 cooling Methods 0.000 claims description 9
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 claims description 9
- 229910052586 apatite Inorganic materials 0.000 claims description 7
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 4
- -1 calcium phosphate compound Chemical class 0.000 claims description 4
- 235000011010 calcium phosphates Nutrition 0.000 claims description 4
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 4
- GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 claims description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 2
- 235000019739 Dicalciumphosphate Nutrition 0.000 claims description 2
- XZMPQELFUMMFEI-UHFFFAOYSA-A [Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O Chemical compound [Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[Ca++].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XZMPQELFUMMFEI-UHFFFAOYSA-A 0.000 claims description 2
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 claims description 2
- 229910000390 dicalcium phosphate Inorganic materials 0.000 claims description 2
- 229940038472 dicalcium phosphate Drugs 0.000 claims description 2
- 230000001678 irradiating effect Effects 0.000 claims description 2
- 238000012423 maintenance Methods 0.000 claims description 2
- 229910000392 octacalcium phosphate Inorganic materials 0.000 claims description 2
- 239000004065 semiconductor Substances 0.000 claims description 2
- YIGWVOWKHUSYER-UHFFFAOYSA-F tetracalcium;hydrogen phosphate;diphosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].OP([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O YIGWVOWKHUSYER-UHFFFAOYSA-F 0.000 claims description 2
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 2
- 235000019731 tricalcium phosphate Nutrition 0.000 claims description 2
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims 1
- 229910052587 fluorapatite Inorganic materials 0.000 claims 1
- 229940077441 fluorapatite Drugs 0.000 claims 1
- 229910000150 monocalcium phosphate Inorganic materials 0.000 claims 1
- 235000019691 monocalcium phosphate Nutrition 0.000 claims 1
- 210000003298 dental enamel Anatomy 0.000 abstract description 29
- 239000011575 calcium Substances 0.000 abstract description 14
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract description 8
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract description 8
- 229910052791 calcium Inorganic materials 0.000 abstract description 8
- 239000011574 phosphorus Substances 0.000 abstract description 8
- 229910052698 phosphorus Inorganic materials 0.000 abstract description 8
- 210000003296 saliva Anatomy 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- 210000001519 tissue Anatomy 0.000 description 17
- 238000000034 method Methods 0.000 description 10
- 238000005259 measurement Methods 0.000 description 7
- 239000010936 titanium Substances 0.000 description 7
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 6
- 229910052719 titanium Inorganic materials 0.000 description 6
- 239000000758 substrate Substances 0.000 description 5
- 239000002245 particle Substances 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 239000002253 acid Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 238000000608 laser ablation Methods 0.000 description 2
- 238000013507 mapping Methods 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- HECLRDQVFMWTQS-UHFFFAOYSA-N Dicyclopentadiene Chemical compound C1C2C3CC=CC3C1C=C2 HECLRDQVFMWTQS-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000003746 surface roughness Effects 0.000 description 1
- 210000000332 tooth crown Anatomy 0.000 description 1
- 230000036346 tooth eruption Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Physical Vapour Deposition (AREA)
- Laser Surgery Devices (AREA)
- Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
Abstract
Description
この発明は、骨や歯などの硬組織に薄膜を形成する薄膜形成装置であって、形成した薄膜が、硬組織表面でイオン化して再石灰化することによって、硬組織の再生を助ける薄膜形成装置に関する。 The present invention is a thin film forming apparatus for forming a thin film on a hard tissue such as a bone or a tooth, and the formed thin film is ionized and recalcified on the surface of the hard tissue to help regenerate the hard tissue. Relates to the device.
エナメル質は、歯の歯冠の最表層にある生体で最も硬い硬組織であり、ハイドロキシアパタイトの結晶の塊が密に詰まったエナメル小柱と呼ばれる基本構造から構成されている。また、エナメル質は、エナメル芽細胞等の働きによって形成されるが、このエナメル芽細胞は歯の萌出時に消滅してしまうため、う歯などによってエナメル質が喪失しても、エナメル質が自然に再生されることはない。 The enamel is the hardest hard tissue in the living body on the outermost layer of the tooth crown, and is composed of a basic structure called an enamel trabeculae packed with hydroxyapatite crystal masses. In addition, enamel is formed by the action of enamel blasts, etc., but these enamel blasts disappear at the time of tooth eruption, so even if enamel is lost due to dental caries, etc. Never played.
そこで、従来から、患部にレジンを塗布することにより、エナメル質を修復する治療法が行われている。ただ、この治療法は、ハイドロキシアパタイト（以下、HApと省略する。）とエナメル質とを一体化して再生する方法ではないので、半永久的な治療ではなく、時間が経つとレジンの剥離や、使用する有機物によるアレルギー反応が生じるなどの問題点があった。 Therefore, conventionally, a treatment method for repairing enamel by applying a resin to the affected area has been performed. However, this treatment method is not a method that regenerates hydroxyapatite (hereinafter abbreviated as HAp) and enamel, so it is not a semi-permanent treatment. There are problems such as allergic reactions caused by organic substances.
これらの問題点を解決するため、HApの粉体や微粒子をエナメル質表面に付着させる方法が試みられている。ただ、HApをエナメル質表面に付着させようとしても、セラミックス同士でありその面粗度の大きさのため、一体化することは非常に困難であった。 In order to solve these problems, attempts have been made to attach HAp powder and fine particles to the enamel surface. However, even if HAp was made to adhere to the enamel surface, it was very difficult to integrate the ceramics due to the surface roughness of the ceramics.
そのため、セラミックスとエナメル質とを一体化できる方法として、エナメル質と同じ成分の人工合成したHApの粉体を高速で歯質表面に噴射する方法（特許文献１を参照。）、HAp粉末と強酸水溶液とを混合し歯科用ペーストとして塗布する方法（特許文献２を参照。）などが検討されている。 Therefore, as a method for integrating ceramics and enamel, artificially synthesized HAp powder having the same components as enamel is sprayed onto the tooth surface at high speed (see Patent Document 1), HAp powder and strong acid. A method of mixing an aqueous solution and applying it as a dental paste (see Patent Document 2) has been studied.
しかし、これらの方法は、高速に加速された粒子や強酸水溶液を使用するため、口腔内組織を傷つけるなど、生体に侵襲を与えるという問題点があった。 However, these methods use particles accelerated at a high speed or strong acid aqueous solution, and thus have a problem of invading the living body, for example, damaging oral tissues.
そこで、この発明は生体を侵襲せずに、エナメル質などの硬組織の再生を助けることができる薄膜形成装置を提供することを目的とする。 In view of the above, an object of the present invention is to provide a thin film forming apparatus capable of assisting regeneration of hard tissue such as enamel without invading a living body.
この発明の薄膜形成装置は、レーザーアブレーション法により硬組織表面にカルシウム（Ca)とリン（P)を含む薄膜を形成する。その後、硬組織に形成された薄膜に含まれるカルシウム（Ca)やリン（P)が体液や唾液などによりイオン化し、再石灰化することによって、エナメル質などの硬組織が非侵襲で再生する。すなわち、この発明の薄膜形成装置は、レーザーアブレーション法によって硬組織に薄膜を形成することを最も主要な特徴とする。 The thin film forming apparatus of the present invention forms a thin film containing calcium (Ca) and phosphorus (P) on the surface of a hard tissue by a laser ablation method. Thereafter, calcium (Ca) and phosphorus (P) contained in the thin film formed in the hard tissue are ionized and recalcified by body fluid, saliva, etc., thereby regenerating the hard tissue such as enamel non-invasively. That is, the thin film forming apparatus of the present invention is characterized by forming a thin film on a hard tissue by a laser ablation method.
この発明の薄膜形成装置を使用することによって、硬組織を非侵襲で再生することができるため、患者に苦痛を与えずに硬組織を再生できる。そのため、従来は、苦痛を恐れて治療を避けていた患者が治療を受け易くなり、ひいては国民の健康の向上に資することができる。 Since the hard tissue can be regenerated non-invasively by using the thin film forming apparatus of the present invention, the hard tissue can be regenerated without causing pain to the patient. As a result, patients who have been afraid of pain and have avoided treatment can easily receive treatment, and thus contribute to the improvement of the national health.
この発明の薄膜形成装置は、硬組織表面に薄膜を形成する装置である。ここで、硬組織とは歯、骨であればよく、その種類は特に限定されない。また、図１に示すように、この発明の薄膜形成装置１は、レーザー照射部１１と、ターゲット１２、ターゲット保持部１３を備えている。そこで、以下にその詳細について説明する。 The thin film forming apparatus of the present invention is an apparatus for forming a thin film on the surface of a hard tissue. Here, the hard tissue may be a tooth or a bone, and the type thereof is not particularly limited. As shown in FIG. 1, the thin film forming apparatus 1 of the present invention includes a laser irradiation unit 11, a target 12, and a target holding unit 13. The details will be described below.
（１）レーザー照射部
レーザー照射部１１は、Er-YAGレーザー（波長2940nm程度）、Er-Cr;YSGGレーザー（波長2780nm程度）、Nd-YAGレーザー（波長1064nm）、半導体レーザー（波長655〜2000nm程度）などのレーザー照射装置である。なお、レーザー照射部は、ターゲット１２にレーザーを照射した時にターゲットを分解・剥離できる波長とエネルギーを持つものであれば、前述のレーザーに限定されるものではない。
(1) Laser irradiation unit The laser irradiation unit 11 includes an Er-YAG laser (wavelength of about 2940 nm), Er-Cr; YSGG laser (wavelength of about 2780 nm), Nd-YAG laser (wavelength of 1064 nm), and semiconductor laser (wavelength of 655 to 2000 nm). Laser irradiation device. The laser irradiation unit is not limited to the above-described laser as long as it has a wavelength and energy capable of decomposing and peeling the target when the target 12 is irradiated with the laser.
また、レーザー照射部１１の形状は、ターゲット１２にレーザーを照射できるのであれば、図１に示す形状に限定されるものではない。例えば、レンズやミラーなどの公知の技術を使用してレーザーの方向を変えるものや、その出力を集中させるものであってもよい。なお、照射するレーザーの波長や出力は、ターゲットや治療対象である硬組織に応じて自由に設定すればよい。 Further, the shape of the laser irradiation unit 11 is not limited to the shape shown in FIG. 1 as long as the target 12 can be irradiated with a laser. For example, it is possible to change the direction of the laser using a known technique such as a lens or a mirror, or to concentrate the output. In addition, what is necessary is just to set freely the wavelength and output of the laser to irradiate according to the hard tissue which is a target and treatment object.
（２）ターゲット
ターゲット１２は生体親和性セラミックスからなる。ここで、生体親和性セラミックスとは、リン酸カルシウム化合物であればよく、カルシウム(Ca)とリン（P）を含んだ混合物である。具体的には、第一リン酸カルシウム(MCPM)、第二リン酸カルシウム(DCPD)、リン酸八カルシウム、リン酸三カルシウム(α−TCP、β-TCP)、リン酸四カルシウム(TTCP)、オクタリン酸カルシウム（OCP）、ハイドロキシアパタイト(HAp)、炭酸アパタイト(CAp)、フッ化アパタイト(FAp)、生体アパタイトなどが例示できる。
(2) Target The target 12 is made of biocompatible ceramics. Here, the biocompatible ceramics may be a calcium phosphate compound, and is a mixture containing calcium (Ca) and phosphorus (P). Specifically, primary calcium phosphate (MCPM), dicalcium phosphate (DCPD), octacalcium phosphate, tricalcium phosphate (α-TCP, β-TCP), tetracalcium phosphate (TTCP), calcium octaphosphate (OCP) ), Hydroxyapatite (HAp), carbonate apatite (CAp), fluorinated apatite (FAp), bioapatite and the like.
また、生体アパタイトとは、[(Ca)10-a Ma][(PO4)6-b Zb][(OH)2-c Xc]の組成を持った鉱物群であり、具体的には、式中のMが例えばNa、Mg、Ba、K、Zn、Alに、Zが例えばSO4、CO3に、XがF、CO3に置き換わったものである。 Bioapatite is a group of minerals with the composition of [(Ca) 10-a M a ] [(PO 4 ) 6-b Z b ] [(OH) 2-c X c ] In the formula, M is replaced with, for example, Na, Mg, Ba, K, Zn, Al, Z is replaced with, for example, SO 4 , CO 3 , and X is replaced with F, CO 3 .
（３）ターゲット保持部
ターゲット保持部１３は、ターゲット１２がレーザーＬの照射線上に位置し、レーザーＬの照射によりターゲット１２から飛散した原子、分子、クラスター、ドロップレットＰが硬組織（歯質Ｔ）に堆積されるように、ターゲット１２を保持するものである。なお、ターゲット保持部１３の形状は、この目的を達成できるのであれば、図１に記載の形状に限定されず、任意の形状を取ることができる。
(3) Target holding unit The target holding unit 13 is configured such that the target 12 is positioned on the irradiation line of the laser L, and atoms, molecules, clusters, and droplets P scattered from the target 12 by the irradiation of the laser L are hard tissues (dentate T ) To hold the target 12 so as to be deposited. The shape of the target holding portion 13 is not limited to the shape shown in FIG. 1 as long as this purpose can be achieved, and can take any shape.
この発明の薄膜形成装置１は、レーザー照射部１１、ターゲット１２、ターゲット保持部１３のほか、図１に示すように、空気Ａを噴出してターゲット１２を冷却する冷却部１４を備えていてもよい。なお、冷却部は、図１に示すターゲット１２を冷却するもののほか、レーザー照射部１１、ターゲット保持部１３を冷却するものであってもよい。 The thin film forming apparatus 1 according to the present invention includes a laser irradiation unit 11, a target 12, and a target holding unit 13 as well as a cooling unit 14 that jets air A and cools the target 12 as shown in FIG. Good. The cooling unit may cool the laser irradiation unit 11 and the target holding unit 13 in addition to cooling the target 12 shown in FIG.
薄膜形成装置１が冷却部１４を備えることによって、レーザー照射に伴う温度上昇によるターゲット１２の破壊、薄膜形成装置１の接触による硬組織付近の火傷、を防ぐことができる。なお、冷却部としては、レーザー照射部１１、ターゲット１２、ターゲット保持部１３を冷却できるのであれば、公知の冷却装置、例えば、空冷装置、水冷装置、ペルチエ素子のような熱電素子などを特に限定することなく使用できる。 By providing the cooling unit 14 with the thin film forming apparatus 1, it is possible to prevent the destruction of the target 12 due to the temperature rise accompanying laser irradiation and the burn near the hard tissue due to the contact with the thin film forming apparatus 1. In addition, as a cooling part, if the laser irradiation part 11, the target 12, and the target holding | maintenance part 13 can be cooled, a well-known cooling device, for example, an air cooling device, a water cooling device, a thermoelectric element like a Peltier element etc. will be specifically limited. Can be used without
以下、実施例によりこの発明を説明するが、この発明は以下の実施例により如何なる意味においても限定されるものではない。 Hereinafter, the present invention will be described by way of examples. However, the present invention is not limited in any way by the following examples.
この発明の薄膜形成装置が、大気中でリン（P）とカルシウム(Ca)を含む薄膜を形成できることを実証した。具体的には、図２に示す薄膜形成装置１を使用して、以下に示すような手順によって、チタン基板上に薄膜を形成し、その組成を調べた。 It has been demonstrated that the thin film forming apparatus of the present invention can form a thin film containing phosphorus (P) and calcium (Ca) in the atmosphere. Specifically, using the thin film forming apparatus 1 shown in FIG. 2, a thin film was formed on a titanium substrate according to the procedure shown below, and the composition was examined.
まず、Er-YAGレーザー（パワー350mJ、パルス速度10pps）１１を高密度HApターゲット（ペンタックス製、商品名セルヤード）１２に10秒間照射して原子、分子、クラスター、ドロップレットＰを発生させて、それらをチタン基板Ｔｉ（φ16mm）上に堆積させ、薄膜を形成した。 First, an Er-YAG laser (power 350 mJ, pulse speed 10 pps) 11 is irradiated to a high-density HAp target (Pentax, product name Cell Yard) 12 for 10 seconds to generate atoms, molecules, clusters, and droplets P, and these Was deposited on a titanium substrate Ti (φ16 mm) to form a thin film.
つぎに、薄膜を走査型電子顕微鏡（SEM）により観察し、チタン板上に堆積した粒子（ドロップレット）をエネルギー分散型X線分析装置（EDX）により元素分析した。その結果を図３及び図４に示す。 Next, the thin film was observed with a scanning electron microscope (SEM), and particles (droplets) deposited on the titanium plate were subjected to elemental analysis with an energy dispersive X-ray analyzer (EDX). The results are shown in FIGS.
なお、図３（ａ）は薄膜の走査型電子顕微鏡（SEM）写真であり、図３（ｂ）はEDX元素マッピングの結果である。また、図４は図３（ａ）に示す各粒子をEDXにより組成分析した結果である。ここで、図４（ａ）は、図３（ａ）の上側ドロップレットを組成分析した結果であり、図４（ｂ）は図３（ａ）の下側ドロップレットを組成分析した結果である。 FIG. 3A is a scanning electron microscope (SEM) photograph of a thin film, and FIG. 3B is a result of EDX element mapping. FIG. 4 shows the result of composition analysis of each particle shown in FIG. Here, FIG. 4A shows the result of composition analysis of the upper droplet of FIG. 3A, and FIG. 4B shows the result of composition analysis of the lower droplet of FIG. .
図３及び図４から、ドロップレットがカルシウムとリンとを含んでいることが確認できた。この結果は、この発明の薄膜形成装置によって、リン酸カルシウム化合物の薄膜が形成できることを示している。 From FIG. 3 and FIG. 4, it was confirmed that the droplets contained calcium and phosphorus. This result shows that a thin film of a calcium phosphate compound can be formed by the thin film forming apparatus of the present invention.
この発明の薄膜形成装置が、大気中でリン（P）とカルシウム(Ca)を含む薄膜をエナメル質上に形成できることを実証した。具体的には、図５に示す薄膜形成装置を使用して、以下に示すような手順によって、エナメル質上に薄膜を形成することを示した。 It has been demonstrated that the thin film forming apparatus of the present invention can form a thin film containing phosphorus (P) and calcium (Ca) on enamel in the atmosphere. Specifically, it was shown that a thin film was formed on enamel by the following procedure using the thin film forming apparatus shown in FIG.
まず、Er-YAGレーザー（パワー200mJ、パルス速度10pps）を生体アパタイトバルク体ターゲット（株式会社エクセラ 天然アパタイト粉末をプレス成型）に5分間照射して原子、分子、クラスター、ドロップレットを発生させて、それらをエナメル質上に堆積させ、薄膜を形成した。 First, an Er-YAG laser (power 200mJ, pulse speed 10pps) is irradiated to a biological apatite bulk target (EXCERA Inc. natural apatite powder press molding) for 5 minutes to generate atoms, molecules, clusters, and droplets. They were deposited on the enamel to form a thin film.
つぎに、生体アパタイトバルク体ターゲットにレーザー照射前と照射後のエナメル質表面を観察した。その結果を図６に示す。 Next, the enamel surface before and after laser irradiation was observed on the biological apatite bulk target. The result is shown in FIG.
なお、図６（ａ）は生体アパタイトバルク体ターゲットにレーザー照射前の写真であり、図６（ｂ）は照射後の結果である。 FIG. 6A is a photograph of the biological apatite bulk target before laser irradiation, and FIG. 6B is the result after irradiation.
図６から、生体アパタイトバルク体ターゲットにレーザー照射後はエナメル質表面に白い堆積物が見られ、ターゲットから飛散した原子や、分子、クラスター、ドロップレットがエナメル質表面に堆積していることが確認できた。この結果は、この発明の薄膜形成装置によって、エナメル質上にリン酸カルシウム化合物の薄膜が形成できることを示している。 Fig. 6 shows that white deposits are observed on the enamel surface after laser irradiation of the biological apatite bulk target, and that atoms, molecules, clusters, and droplets scattered from the target are deposited on the enamel surface. did it. This result shows that a thin film of calcium phosphate compound can be formed on the enamel by the thin film forming apparatus of the present invention.
また、図７は、形状測定レーザマイクロスコープ（VK-X110）によって測定したエナメル質表面に形成されたHAp薄膜の一部分の断面の測定結果である。 FIG. 7 shows a measurement result of a cross section of a part of the HAp thin film formed on the enamel surface measured by a shape measurement laser microscope (VK-X110).
なお、図７（ａ）は断面の測定部位の範囲を示し、図７（ｂ）は測定部位におけるHAp薄膜の高さの分布を示している。図７（ｂ）より、最大高さ約10μm以下のHAp薄膜が堆積したことが分かる。 7A shows the range of the measurement site in the cross section, and FIG. 7B shows the height distribution of the HAp thin film at the measurement site. FIG. 7B shows that a HAp thin film having a maximum height of about 10 μm or less was deposited.
１ 薄膜形成装置
１１ レーザー照射部
１２ ターゲット
１３ ターゲット保持部
DESCRIPTION OF SYMBOLS 1 Thin film forming apparatus 11 Laser irradiation part 12 Target 13 Target holding part
Claims (4)
生体親和性セラミックスからなるターゲットと、
ターゲットがレーザーの照射線上に位置し、レーザーの照射によってターゲットから飛散した原子、分子、クラスター、ドロップレットが硬組織に堆積されるように、レーザー照射部及びターゲットを保持するターゲット保持部と、
を備え、硬組織に薄膜を形成する薄膜形成装置。 A laser irradiation unit for irradiating a laser;
A target made of biocompatible ceramics;
A target holding unit for holding the laser irradiation unit and the target so that the target is positioned on the laser irradiation line, and atoms, molecules, clusters, and droplets scattered from the target by the laser irradiation are deposited on the hard tissue;
A thin film forming apparatus for forming a thin film on a hard tissue.
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| JP2015059261A (en) * | 2013-09-20 | 2015-03-30 | 学校法人近畿大学 | Thin film deposition system, and method of forming apatite thin film using the thin film deposition system |
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