JP2013078334A5 - - Google Patents
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- JP2013078334A5 JP2013078334A5 JP2012278814A JP2012278814A JP2013078334A5 JP 2013078334 A5 JP2013078334 A5 JP 2013078334A5 JP 2012278814 A JP2012278814 A JP 2012278814A JP 2012278814 A JP2012278814 A JP 2012278814A JP 2013078334 A5 JP2013078334 A5 JP 2013078334A5
- Authority
- JP
- Japan
- Prior art keywords
- thermolysin
- thermolysin variant
- variant
- composition
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Claims (11)
- 改良された安定性及び/又は効果を持つ単離されたサーモリシン変異体であって、 前記サーモリシン変異体は、配列番号3に示すアミノ酸配列の6、7、49、56、58、61、63、75、128、151、156、196、273、278、及び280の位置と同等の位置から選択された1、2、3、4又は5の置換を含み、前記サーモリシン変異体が、配列番号3に示すアミノ酸配列と少なくとも95%のアミノ酸の同一性を持つ、単離されたサーモリシン変異体。
- 前記サーモリシン変異体が、ジオバチルス カルドプロテオリチカス又はジオバチルス ステアロサーモフィルスの変異体である、請求項1の単離されたサーモリシン変異体。
- 前記改良は、改良された熱安定性、約5.0から約11.5のpH条件下で改良された効果、より高いpH条件下で改良された効果、及び改良された自己分解安定性の内の一以上の改良を含む、請求項1の単離されたサーモリシン変異体。
- サーモリシン活性を持つ請求項1に記載の酵素を生成する方法であって、 i)配列番号3に示すアミノ酸配列と95から99%のアミノ酸の同一性を持つサーモリシン変異体をコードするポリヌクレオチドを含む発現ベクターにより宿主細胞を形質転換すること、 ii)前記サーモリシンの生成に適した条件下で前記形質転換された宿主細胞を培養すること、及び iii) 生成されたサーモリシンを収穫すること、 を含む、前記方法。
- 請求項1に記載のサーモリシン変異体を含む組成物。
- 前記組成物は洗浄組成物である、請求項7の組成物。
- 前記洗浄組成物は洗剤である、請求項8の組成物。
- プロテアーゼ、アミラーゼ、リパーゼ、マンナーゼ、ペクチナーゼ、クチナーゼ、オキシドレダクターゼ、ヘミセルラーゼ及びセルラーゼから選択される少なくとも一つの追加の酵素又は酵素誘導体をさらに含む、請求項7の組成物。
- 前記組成物は、動物の飼料用組成物、繊維加工用組成物、及び皮革加工用組成物から選択される、請求項7に記載の単離サーモリシン変異体を含む組成物。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98466407P | 2007-11-01 | 2007-11-01 | |
US60/984,664 | 2007-11-01 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010533069A Division JP2011502506A (ja) | 2007-11-01 | 2008-10-28 | サーモリシン及びその変異体の生成及び液体洗剤での使用 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015180557A Division JP2016052306A (ja) | 2007-11-01 | 2015-09-14 | サーモリシン及びその変異体の生成及び液体洗剤での使用 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2013078334A JP2013078334A (ja) | 2013-05-02 |
JP2013078334A5 true JP2013078334A5 (ja) | 2013-06-13 |
JP6139877B2 JP6139877B2 (ja) | 2017-05-31 |
Family
ID=40345178
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010533069A Pending JP2011502506A (ja) | 2007-11-01 | 2008-10-28 | サーモリシン及びその変異体の生成及び液体洗剤での使用 |
JP2012278814A Active JP6139877B2 (ja) | 2007-11-01 | 2012-12-21 | サーモリシン及びその変異体の生成及び液体洗剤での使用 |
JP2015180557A Pending JP2016052306A (ja) | 2007-11-01 | 2015-09-14 | サーモリシン及びその変異体の生成及び液体洗剤での使用 |
JP2017197384A Active JP6894342B2 (ja) | 2007-11-01 | 2017-10-11 | サーモリシン及びその変異体の生成及び液体洗剤での使用 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010533069A Pending JP2011502506A (ja) | 2007-11-01 | 2008-10-28 | サーモリシン及びその変異体の生成及び液体洗剤での使用 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015180557A Pending JP2016052306A (ja) | 2007-11-01 | 2015-09-14 | サーモリシン及びその変異体の生成及び液体洗剤での使用 |
JP2017197384A Active JP6894342B2 (ja) | 2007-11-01 | 2017-10-11 | サーモリシン及びその変異体の生成及び液体洗剤での使用 |
Country Status (11)
Country | Link |
---|---|
US (4) | US8569034B2 (ja) |
EP (2) | EP2205732A2 (ja) |
JP (4) | JP2011502506A (ja) |
KR (1) | KR20100075993A (ja) |
CN (2) | CN101868538B (ja) |
BR (1) | BRPI0818144A2 (ja) |
CA (1) | CA2704311C (ja) |
DK (1) | DK2845900T3 (ja) |
MX (1) | MX2010004326A (ja) |
RU (2) | RU2536255C2 (ja) |
WO (1) | WO2009058303A2 (ja) |
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2008
- 2008-10-28 RU RU2010122072/10A patent/RU2536255C2/ru active
- 2008-10-28 MX MX2010004326A patent/MX2010004326A/es active IP Right Grant
- 2008-10-28 CA CA2704311A patent/CA2704311C/en active Active
- 2008-10-28 US US12/740,782 patent/US8569034B2/en not_active Expired - Fee Related
- 2008-10-28 CN CN2008801142680A patent/CN101868538B/zh not_active Expired - Fee Related
- 2008-10-28 EP EP08845951A patent/EP2205732A2/en not_active Withdrawn
- 2008-10-28 KR KR1020107009728A patent/KR20100075993A/ko not_active Application Discontinuation
- 2008-10-28 CN CN201310231226.8A patent/CN103305493B/zh not_active Expired - Fee Related
- 2008-10-28 BR BRPI0818144-6A2A patent/BRPI0818144A2/pt not_active Application Discontinuation
- 2008-10-28 EP EP14189403.0A patent/EP2845900B1/en active Active
- 2008-10-28 DK DK14189403.0T patent/DK2845900T3/en active
- 2008-10-28 JP JP2010533069A patent/JP2011502506A/ja active Pending
- 2008-10-28 WO PCT/US2008/012276 patent/WO2009058303A2/en active Application Filing
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2012
- 2012-12-21 JP JP2012278814A patent/JP6139877B2/ja active Active
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2013
- 2013-09-24 US US14/035,441 patent/US20140099698A1/en not_active Abandoned
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2014
- 2014-10-09 RU RU2014140895A patent/RU2733541C2/ru active
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2015
- 2015-07-08 US US14/794,687 patent/US9976134B2/en active Active
- 2015-09-14 JP JP2015180557A patent/JP2016052306A/ja active Pending
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2017
- 2017-10-11 JP JP2017197384A patent/JP6894342B2/ja active Active
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2018
- 2018-05-03 US US15/969,954 patent/US20180251742A1/en not_active Abandoned
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