JP2013056855A - 口腔用組成物 - Google Patents
口腔用組成物 Download PDFInfo
- Publication number
- JP2013056855A JP2013056855A JP2011196315A JP2011196315A JP2013056855A JP 2013056855 A JP2013056855 A JP 2013056855A JP 2011196315 A JP2011196315 A JP 2011196315A JP 2011196315 A JP2011196315 A JP 2011196315A JP 2013056855 A JP2013056855 A JP 2013056855A
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- JP
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- Prior art keywords
- extract
- biofilm formation
- plant
- biofilm
- oral composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Abstract
【解決手段】小松菜、水菜、壬生菜、辛味大根、クレス、コゴミ、タラノキ、またはアイスプラントの熱水抽出物である植物抽出物を含有する口腔用組成物。
【選択図】図2
Description
A. naeslundiiのバイオフィルム形成は酸刺激により増加するが、上記植物を培養系に1000ppm添加すると、バイオフィルム形成が約30%程度に低下することを発見した。このとき、各植物抽出物はA. naeslundiiの生育に影響を及ぼさなかったため、このバイオフィルム形成抑制効果は抗菌作用とは異なるメカニズムであると考えられる。
ここでA. naeslundiiは、歯肉炎や根面う蝕部位から発見されるグラム陽性桿菌で、初期歯周病の原因細菌と言われている。連鎖球菌や歯周病原菌と共凝集するため、歯周病プラークへの菌叢遷移の鍵をにぎる細菌であると考え、A. naeslundiiをコントロールすることが効果的な歯周病予防に繋がると考えられる。
本発明者らは口腔細菌の産生する酸によりバイオフィルム形成が増加することを確認した。
すなわち、本発明は、植物抽出物を含有する口腔用組成物に関し、該植物抽出物が、小松菜、水菜、壬生菜、辛味大根、クレス、コゴミ、タラノキ、またはアイスプラントの熱水抽出物である口腔用組成物に関する。
(抽出物調製)
各植物サンプルは市販品を購入し凍結乾燥後、1gを粉砕機で細かく粉砕し、水50mlで70℃で2時間抽出した。得られた抽出液は、3000rpm・10分間遠心分離し、上清を濾過後、凍結乾燥したものを各植物熱水抽出物として試験に供した。
(バイオフィルム形成抑制活性評価)
1.バイオフィルム形成
A. naeslundii ATCC19039株を5mlのBrain Heart Infusion(BHI)液体培地にて37℃で10時間嫌気培養し、3000rpm・10分間遠心分離して集めた細菌を、PBSにてOD550nm=0.5に調製し、これを供試菌懸濁液とした。
バイオフィルム形成は、96穴マイクロプレートを用いて試験を行った。各ウェルに、バイオフィルム形成阻害サンプル60μl、酪酸20μl、A. naeslundii供試菌懸濁液20μl、0.25% Sucrose添加 Toripticase soy broth 100μlを添加し、37℃で5%CO2条件下で16時間培養を行った。
上記した培養後の上清を取り除き、PBSにて2回各ウェルの洗浄を行った。洗浄後、各ウェルに0.25%サフラニン溶液を添加し15分間静置後余剰サフラニン溶液を取り除き、PBSにて2回各ウェルの洗浄を行った。洗浄後各ウェルにエタノールを添加し、30分間振とうすることで染色させたサフラニンを溶出させ、マイクロプレートリーダーを用いて492nmの吸光度で測定し、バイオフィルム形成量を定量した。
バイオフィルム形成量は、サンプルを添加していないときの形成量を100としたときの割合で示した。
1. 天然物抽出物のバイオフィルム形成抑制効果
酪酸添加系において、さまざまな天然物の抽出物にバイオフィルム形成抑制活性が見られるかを検討した。さまざまな植物の熱水抽出物を調製し、バイオフィルム形成抑制活性を測定した結果、小松菜、水菜、壬生菜、辛味大根、クレス、コゴミ、タラノキ、アイスプラントの熱水抽出物を試験系に添加すると、酪酸を添加していない系ではバイオフィルム形成量に大きな変化は見られなかったが、酪酸を添加した系ではバイオフィルム形成量が50〜90%低下することが確認された。この効果は、特にアブラナ科の植物熱水抽出物で顕著であった(表1)。
下記処方に従って含そう剤を製造した。
エタノール 2.0重量%
小松菜抽出物 1.0
香料 1.0
水 残
100.0
下記処方に従って練り歯磨きを製造した。
炭酸カルシウム 50.0重量%
グリセリン 19.0
壬生菜抽出物 1.0
カルボオキシメチルセルロース 2.0
ラルリル硫酸ナトリウム 2.0
香料 1.0
サッカリン 0.1
クロルヘキシジン 0.01
水 残
100.0
下記処方に従って口臭用スプレーを製造した。
エタノール 10.0重量%
グリセリン 5.0
辛味大根抽出物 1.0
香料 0.05
着色料 0.001
水 残
100.0
下記処方に従ってトローチを製造した。
クレス抽出物 92.3重量%
アラビアガム 6.0
香料 1.0
モノフルオロリン酸ナトリウム 0.7
100.0
下記処方に従ってチューインガムを製造した。
ガムベース 20.0重量%
キシリトール 54.7
マルトース 15.0
ソルビトール 9.3
香料 0.5
水菜抽出物 0.5
100.0
下記処方に従ってキャンディを製造した。
砂糖 50.0重量%
還元水あめ 33.0
クエン酸 1.0
香料 0.2
L-メントール 1.0
水菜抽出物 0.4
水 残
100.0
下記処方に従って錠菓を製造した。
砂糖 74.7重量%
乳糖 18.9
アイスプラント抽出物 2.0
ショ糖脂肪酸エステル 0.15
水 4.25
100.0
下記処方に従ってグミゼリーを製造した。
ゼラチン 60.0重量%
還元水あめ 32.4
タラノキ抽出物 0.5
植物油脂 4.5
リンゴ酸 2.0
香料 0.5
100.0
下記処方に従って飲料を製造した。
オレンジ果汁 30.0重量%
コゴミ抽出物 0.5
クエン酸 0.1
ビタミンC 0.04
香料 0.1
水 残
100.0
Claims (9)
- 植物抽出物を含有する口腔用組成物。
- 前記植物抽出物が、小松菜、水菜、壬生菜、辛味大根、クレス、コゴミ、タラノキ、またはアイスプラントの熱水抽出物である請求項1に記載の口腔用組成物。
- 植物抽出物を含有する酸誘導バイオフィルム形成抑制剤。
- 前記植物抽出物が、小松菜、水菜、壬生菜、辛味大根、クレス、コゴミ、タラノキ、またはアイスプラントの熱水抽出物である請求項3に記載の酸誘導バイオフィルム形成抑制剤。
- 請求項1または2に記載の口腔用組成物からなる含そう剤。
- 請求項1または2に記載の口腔用組成物からなる練り歯磨き剤。
- 請求項1または2に記載の口腔用組成物からなる吸入剤。
- 請求項1または2に記載の口腔用組成物からなるトローチ剤。
- 請求項1または2に記載の口腔用組成物を含有する食品。
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JP2011196315A JP6016343B2 (ja) | 2011-09-08 | 2011-09-08 | 口腔用組成物 |
PCT/JP2012/005662 WO2013035333A1 (ja) | 2011-09-08 | 2012-09-06 | 口腔用組成物 |
CN201280043403.3A CN103781466A (zh) | 2011-09-08 | 2012-09-06 | 口腔用组合物 |
KR1020147009143A KR102008035B1 (ko) | 2011-09-08 | 2012-09-06 | 구강용 조성물 |
US14/343,418 US20140227203A1 (en) | 2011-08-09 | 2012-09-06 | Oral composition |
EP12830632.1A EP2754433A1 (en) | 2011-09-08 | 2012-09-06 | Oral composition |
US15/453,355 US10201493B2 (en) | 2011-09-08 | 2017-03-08 | Method of reducing oral biofilm |
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WO2014118829A1 (ja) * | 2013-02-01 | 2014-08-07 | 株式会社ロッテ | 口腔用組成物 |
CN104000264A (zh) * | 2014-05-29 | 2014-08-27 | 陕西师范大学 | 一种荚果蕨饮料及其制备方法 |
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KR101561441B1 (ko) * | 2015-05-12 | 2015-10-20 | 대한민국(환경부 국립생물자원관장) | 도깨비가지 추출물을 유효성분으로 함유하는 치주질환 예방 또는 치료용 조성물 |
CN114173742A (zh) * | 2019-07-08 | 2022-03-11 | 巴斯夫欧洲公司 | 口腔护理软糖 |
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Also Published As
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WO2013035333A1 (ja) | 2013-03-14 |
EP2754433A1 (en) | 2014-07-16 |
CN103781466A (zh) | 2014-05-07 |
US10201493B2 (en) | 2019-02-12 |
US20170181962A1 (en) | 2017-06-29 |
JP6016343B2 (ja) | 2016-10-26 |
KR20140062123A (ko) | 2014-05-22 |
US20140227203A1 (en) | 2014-08-14 |
KR102008035B1 (ko) | 2019-08-06 |
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