JP2012528625A - 薬物送達デバイス用のリセット機構 - Google Patents
薬物送達デバイス用のリセット機構 Download PDFInfo
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Abstract
【選択図】図6
Description
ここで一実施態様において、薬学的に活性な化合物は、最大で1500Daまでの分子量を有し、及び/又は、ペプチド、蛋白質、多糖類、ワクチン、DNA、RNA、抗体、酵素、抗体、ホルモン若しくはオリゴヌクレオチド、又は上述の薬学的に活性な化合物の混合物であり、
ここで、更なる実施態様において、薬学的に活性な化合物は、糖尿病、又は糖尿病性網膜症などの糖尿病関連の合併症、深部静脈又は肺血栓塞栓症などの血栓塞栓症、急性冠症候群(ACS)、狭心症、心筋梗塞、癌、黄斑変性症、炎症、枯草熱、アテローム性動脈硬化症及び/又は関節リウマチの処置、及び/又は、予防に有用であり、
ここで、更なる実施態様において、薬学的に活性な化合物は、糖尿病、又は糖尿病性網膜症などの糖尿病に関連する合併症の処置、及び/又は、予防のための少なくとも1つのペプチドを含み、
ここで、更なる実施態様において、薬学的に活性な化合物は、少なくとも1つのヒトインスリン、又はヒトインスリン類似体若しくは誘導体、グルカゴン様ペプチド(GLP−1)、又はその類似体若しくは誘導体、又はエキセジン−3又はエキセジン−4、若しくはエキセジン−3又はエキセジン−4の類似体若しくは誘導体を含む。
H−(Lys)4−desPro36,desPro37エキセンジン−4(1−39)−NH2、
H−(Lys)5−desPro36,desPro37エキセンジン−4(1−39)−NH2、
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);又は
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
ここで、基−Lys6−NH2は、エキセンジン−4誘導体のC−末端と結合してもよく;
H−(Lys)6−desPro36[Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desAsp28,Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28 Pro36,Pro37,Pro38[Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−des Pro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desMet(O)14,Asp28,Pro36,Pro37,Pro38 エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5,desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Lys6−desPro36[Met(O)14,Trp(O2)25, Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28,Pro36,Pro37,Pro38[Met(O)14,Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−des Pro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(S1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
又は前述のエキセンジン−4誘導体のいずれか1つの薬学的に許容される塩若しくは溶媒和物;
から選択される。
Publishing社,Easton, Pa., U.S.A.,1985 及び Encyclopedia of Pharmaceutical Technologyに記載されている。
Claims (15)
- 薬物送達デバイスのスピンドルを駆動するための駆動器であって、該駆動器が第一コンポーネント(44;207)、及び該第一コンポーネント(44;207)に回転的に連結された第二コンポーネント(46;212)を含んでなり、ここで、該薬物送達デバイスのリセット中に、上記第一コンポーネント(44;207)が上記第二コンポーネント(46;212)から回転的に連結解除される、駆動器。
- 第一コンポーネント(207)が第一構成部品(210)及び第二構成部品(211)を含む、請求項1に記載の駆動器駆動器。
- 請求項1に記載の駆動器であって、第一コンポーネント(44;207)が統合された構成部品である、駆動器。
- 該薬物送達デバイスのリセット中に、前記第一コンポーネントを軸方向に動かすことによって、前記第一コンポーネント(44;207)が前記第二コンポーネント(46;212)から連結解除される、請求項1〜3の何れか1項に記載の駆動器。
- 前記薬物送達デバイスが薬剤の用量を設定するために使用されるとき、前記第一コンポーネント(44;207)及び前記第二コンポーネント(46;212)の両者が同じ速度で一緒に回転する、請求項1〜4の何れか1項に記載の駆動器。
- 前記デバイスが薬剤の設定された用量を注射するために使用されるとき、前記第一コンポーネント(44;207)及び前記第二コンポーネント(46;212)の両者が回転し及び/又は軸方向に動く、請求項1〜5の何れか1項に記載の駆動器。
- 薬物送達デバイスと共に使用するためのリセット可能な用量設定機構であって、該機構は、
ハウジング(40;204、208)、該ハウジングに対して回転可能に係合している回転スリーブ(10;206)、及び第一コンポーネント(44;207)及び第二コンポーネント(46;212)を持つ、請求項1〜6の何れか1項に記載の駆動器(30;209)以下を含んでなり、 ここで上記第一及び上記第二のコンポーネントが動作可能なように一緒に連結され、そしてスピンドル(42;214)が前記駆動器に動作可能なように連結され、
その結果、使用者が該回転スリーブを回転することによって用量を設定するとき、前記駆動器の前記第一コンポーネント(44;207)及び該第二コンポーネント(46;212)の両者が一緒に回転し、そして
その結果、該使用者が該用量設定機構をリセットするとき、前記駆動器の該第一コンポーネント(44;207)が該駆動器の前記第二コンポーネント(46;212)から連結解除され、そして前記第一コンポーネントが回転できて元の位置に戻る、
用量設定機構。 - 請求項1〜6の何れか1項に記載の駆動器(30、209)を含んでなり、さらにスピンドル(42;214)、及びスピンドル(42;214)と係合したスピンドルガイドを更に含んでなる、薬物送達デバイスのための用量設定機構であって、ここで、該薬物送達デバイスのリセット中に、該スピンドル(42;214)が回転し、一方、該スピンドルガイドが回転しない、用量設定機構。
- 請求項1〜6の何れか1項に記載の駆動器(30、209)を含んでなる、薬物送達デバイスのための用量設定機構であって、用量制限デバイス(38、218)を更に含んでなり、ここで前記薬物送達デバイスのリセット中に、前記用量制限デバイス(38、218)が初期位置にリセットされる、用量設定機構。
- 請求項1〜6の何れか1項に記載の駆動器(30、209)を含んでなる、薬物送達デバイスのための用量設定機構であって、スピンドル(42;214)を更に含んでなり、ここで前記薬物送達デバイスが薬剤の該設定された用量を注射するために使用されるとき、該スピンドルが並進する、用量設定機構。
- 前記用量設定機構に開放可能に連結されたカートリッジホルダ(6)を更に含んでなる請求項7〜10の何れか1項に記載の用量設定機構であって、ここで、該カートリッジホルダを前記用量設定機構から連結解除することによって、前記第一コンポーネント(44;207)の前記第二コンポーネント(36;212)からの連結解除が実行される、用量設定機構。
- スピンドル(42;214)を更に含んでなる請求項7〜11の何れか1項に記載の用量設定機構であって、ここで、該スピンドルの軸方向の動きによって、前記第一コンポーネント(44;207)の前記第二コンポーネント(46;212)からの連結解除が実行される、用量設定機構。
- 付勢手段を更に含んでなる請求項7〜11の何れか1項に記載の用量設定機構であって、ここで該付勢手段によって、前記第一コンポーネント(44;207)の前記第二コンポーネント(46;212)からの連結解除が実行される、用量設定機構。
- 該ハウジングが外部ハウジング(40;204)を含む、請求項7〜13の何れか1項に記載の用量設定機構。
- 該ハウジングが内部ハウジング(208)を含む、請求項7〜14の何れか1項に記載の用量設定機構。
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