JP2012510353A - 改良された流動機構を用いたノンフロースルー装置及び方法 - Google Patents
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Abstract
Description
本願は、これにより本明細書中にその全体が援用される、2008年10月14日に出願された米国仮出願第61/105247号を基づき、それに基づく優先権を主張する。
a)反応器に試薬を供給するステップ、
b)試薬を処理して所望の生成物を生成するステップ、及び
c)生成物を収集するステップ
である。
フッ化物の濃縮
溶剤交換
フッ素化
加水分解
20 マイクロ流体システム
212 反応室
214 反応器ブロック
216 流入ブロック
218 生成物流出ポート
220 第1の液体流入ポート
222 第2の液体流入ポート
224 気体流出ポート
226 気体流入ポート
328 接線スリット
430 第1の導管
432 第2の導管
Claims (43)
- マルチステップ化学プロセスを遂行するノンフロースルー装置であって、
その容積が一つ以上の流入試薬/反応物の量とは無関係である渦流反応器と、
前記反応室から気体及び/又は液体、又はその混合物を除去できるように構成された一つ以上の流出口と、
前記反応器の壁に接する方向に前記反応器に気体及び/又は液体、又はその混合物を供給し、それにより、前記反応器内に前記気体及び/又は前記液体、又は前記その混合物のサイクロン/渦運動を作り出して一つ以上の化学プロセスステップを遂行するように構成された一つ以上の流入口と
を備えるノンフロースルー装置。 - 前記化学プロセスステップは、一つ以上の流入試薬の濃縮を含むことを特徴とする請求項1に記載の装置。
- 前記化学プロセスステップは、前記試薬の混合を含むことを特徴とする請求項1に記載の装置。
- 前記化学プロセスステップは、一つ以上の溶剤の蒸発を含むことを特徴とする請求項1に記載の装置。
- 前記化学プロセスステップは、一つ以上の溶剤の交換を含むことを特徴とする請求項1に記載の装置。
- 前記化学プロセスステップは、少なくとも一つの反応生成物の濃縮を含むことを特徴とする請求項1に記載の装置。
- 前記化学プロセスステップは、キャリアガスの温度、圧力及び流速を制御することにより遂行されることを特徴とする請求項1に記載の装置。
- 前記制御された温度範囲は、約−78℃から約400℃であることを特徴とする請求項7に記載の装置。
- 前記化学プロセスステップは、周囲温度で遂行されることを特徴とする請求項7に記載の装置。
- 前記反応器は、約−1気圧から30気圧まで加圧できることを特徴とする請求項7に記載の装置。
- キャリアガスの前記流速は、約0から約100scfmであることを特徴とする請求項1に記載の装置。
- 前記試薬は、低濃度/大量で供給されることを特徴とする請求項1に記載の装置。
- 反応は、高濃度かつ少量で進行することを特徴とする請求項1に記載の装置。
- 濃縮された反応生成物は、大量/低濃度で溶出されることを特徴とする請求項1に記載の装置。
- 前記反応は、加熱された流入キャリアガスにより移動しながら加熱されることを特徴とする請求項1に記載の装置。
- 外部熱源が、前記渦流反応器の底部に適用されて化学プロセスを遂行することを特徴とする請求項1に記載の装置。
- 前記反応器の内部容積は約50μLから約10,000Lまでであることを特徴とする請求項1に記載の装置。
- 高沸点溶剤の完全な蒸発が遂行されることを特徴とする請求項1に記載の装置。
- 前記高沸点溶剤は、DMSO、DMF、スルホラン、及び水を含むことを特徴とする請求項18に記載の装置。
- 少なくとも二つの試薬が、実質的に同時に供給されることを特徴とする請求項1に記載の装置。
- 前記渦流反応器は、規模可変であることを特徴とする請求項1に記載の装置。
- 多数の渦流反応器が可変構成で接続され、前記構成は、直列、並列、ライブリ又はネットワークを作るための多重経路への分割を含むことを特徴とする請求項1に記載の装置。
- 前記装置は、マイクロ流体装置であることを特徴とする請求項1に記載の装置。
- 前記反応器の容積は、約5μLから約1000μLであることを特徴とする請求項23に記載のマイクロ流体装置。
- 前記温度は、約−78℃から約400℃であることを特徴とする請求項23に記載のマイクロ流体装置。
- 前記圧力は、約0から約50psiであることを特徴とする請求項23に記載のマイクロ流体装置。
- キャリアガスの前記流速は、約0から約10scfmであることを特徴とする請求項23に記載のマイクロ流体装置。
- 前記反応生成物は、約1から約60秒で得られることを特徴とする請求項23に記載のマイクロ流体装置。
- 前記化学プロセスは、放射性標識化合物の放射性合成であることを特徴とする請求項1に記載のマイクロ流体装置。
- 反応器への加圧ガスの接線方向の流入により作り出された渦流反応器内の気体及び/又は液体又はその混合物のサイクロン運動により遂行されるマルチステップ化学プロセスの方法であって、以下のステップ、
a)前記反応器に前記試薬を供給するステップと、
b)前記試薬を処理して所望の生成物を生成するステップと、
c)前記生成物を収集するステップと
を含む方法。 - 少なくとも二つの試薬が、実質的に同時に供給されることを特徴とする請求項30に記載の方法。
- 低濃度で供給された一つ以上の試薬が、反応物の流入に先立ち所望量に濃縮されることを特徴とする請求項30に記載の方法。
- 溶剤交換をさらに含む請求項30に記載の方法。
- 溶剤の交換が残留水分の除去をもたらし、濃縮残留物の乾燥を促進することを特徴とする請求項33に記載の方法。
- 前記試薬を混合して前記渦流反応器内の圧力及び温度を制御することにより、化学反応を遂行するステップをさらに含む請求項30に記載の方法。
- 前記試薬を加熱又は冷却して、加熱又は冷却された流入キャリアガスの渦流供給により化学反応を遂行するステップをさらに含む請求項30に記載の方法。
- 前記反応器の底部に適用された外部熱源により、前記試薬を加熱して化学反応を遂行するステップをさらに含む請求項30に記載の方法。
- さらなる処理のために前記反応器から前記生成物を溶出するステップをさらに含み、前記試薬が前記反応室中に連続的に注入されることを特徴とする請求項30に記載の方法。
- 前記渦流反応器は、マイクロ流体渦流反応器であることを特徴とする請求項30に記載の方法。
- 放射性標識化合物の放射性合成のための請求項39に記載の方法。
- 渦流反応器内の加圧ガスの流速を制御することにより、さらなる分析のために進行中の化学反応をサンプル抽出する方法。
- 前記渦流反応器は、マイクロ流体渦流反応器であることを特徴とする請求項41に記載の方法。
- 前記化学反応は、放射性標識化合物の放射性合成であることを特徴とする請求項41に記載の方法。
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US12/578,175 US20100093098A1 (en) | 2008-10-14 | 2009-10-13 | Nonflow-through appratus and mehod using enhanced flow mechanisms |
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EP (1) | EP2352581A2 (ja) |
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Publication number | Priority date | Publication date | Assignee | Title |
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JP2014087752A (ja) * | 2012-10-30 | 2014-05-15 | Toray Eng Co Ltd | マイクロリアクタシステムとそれを用いた化合物製造方法およびアルケニルリン化合物の製造方法 |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9139316B2 (en) | 2010-12-29 | 2015-09-22 | Cardinal Health 414, Llc | Closed vial fill system for aseptic dispensing |
US20130102772A1 (en) | 2011-07-15 | 2013-04-25 | Cardinal Health 414, Llc | Systems, methods and devices for producing, manufacturing and control of radiopharmaceuticals-full |
US9417332B2 (en) | 2011-07-15 | 2016-08-16 | Cardinal Health 414, Llc | Radiopharmaceutical CZT sensor and apparatus |
WO2013012813A1 (en) | 2011-07-15 | 2013-01-24 | Cardinal Health 414, Llc | Modular cassette synthesis unit |
US9067189B2 (en) | 2012-03-30 | 2015-06-30 | General Electric Company | Microfluidic device and a related method thereof |
US20160018365A1 (en) * | 2014-06-13 | 2016-01-21 | Masoud Agah | Functionalized Metal Oxides As A Stationary Phase And A Surface Template For Micro Gas Chromatography Separation Columns |
JP2021048336A (ja) * | 2019-09-20 | 2021-03-25 | 三菱電機株式会社 | 処理液生成方法、処理液生成機構、半導体製造装置及び半導体製造方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS50106873A (ja) * | 1973-12-14 | 1975-08-22 | ||
WO2002089965A1 (de) * | 2001-05-07 | 2002-11-14 | INSTITUT FüR MIKROTECHNIK MAINZ GMBH | Verfahren und statischer mischer zum mischen mindestens zweier fluide |
US20040125689A1 (en) * | 2001-05-07 | 2004-07-01 | Wolfgang Ehrfeld | Method and statistical micromixer for mixing at least two liquids |
JP2005512760A (ja) * | 2001-05-07 | 2005-05-12 | ユーオーピー エルエルシー | 少なくとも2つの流体を混合及び反応させるための装置 |
JP2006528542A (ja) * | 2003-07-25 | 2006-12-21 | ウエラ アクチェンゲゼルシャフト | 静的ミクロミキサーを用いた抽出方法 |
JP2008522795A (ja) * | 2004-12-03 | 2008-07-03 | カリフォルニア インスティチュート オブ テクノロジー | 化学反応回路を有するマイクロ流体装置 |
Family Cites Families (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2002166A (en) * | 1932-03-30 | 1935-05-21 | Bandes Julius | Playing card cabinet |
US2716017A (en) * | 1952-08-28 | 1955-08-23 | Grinnell Corp | Diaphragm valves |
US2971851A (en) * | 1958-11-25 | 1961-02-14 | Miles Lab | Scavenger packet |
US3378406A (en) * | 1965-12-30 | 1968-04-16 | Leesona Corp | Metal-oxygen-containing electro-chemical battery |
US3407096A (en) * | 1966-01-25 | 1968-10-22 | American Cyanamid Co | Fuel cell and method for preparing the electrodes |
FR1501835A (fr) * | 1966-09-22 | 1967-11-18 | Wonder Piles | Perfectionnements aux membranes étanches aux liquides mais perméables aux gaz, notamment pour piles et accumulateurs |
US3613729A (en) * | 1970-02-16 | 1971-10-19 | Packard Instrument Co Inc | Valve system |
US3663409A (en) * | 1970-05-14 | 1972-05-16 | Beckman Instruments Inc | Pressure compensation of membranetype sensors |
US4062750A (en) * | 1974-12-18 | 1977-12-13 | James Francis Butler | Thin film electrochemical electrode and cell |
US4326518A (en) * | 1980-04-07 | 1982-04-27 | Baxter Travenol Laboratories, Inc. | Separable integral donor connector with manual clamping means |
US4500905A (en) * | 1981-09-30 | 1985-02-19 | Tokyo Shibaura Denki Kabushiki Kaisha | Stacked semiconductor device with sloping sides |
US4536121A (en) * | 1983-04-22 | 1985-08-20 | Foster Wheeler Energy Corporation | Divided rotary valve feeder |
FI840846A0 (fi) * | 1984-03-02 | 1984-03-02 | Labsystems Oy | Ventilanordning |
US4721133A (en) * | 1985-09-26 | 1988-01-26 | Alcon Laboratories, Inc. | Multiple use valving device |
US4977948A (en) * | 1988-07-15 | 1990-12-18 | General Motors Corporation | Countergravity casting apparatus and method using elastomeric sealing gasket and cooled vacuum chamber |
US4924241A (en) * | 1989-08-01 | 1990-05-08 | Diagraph Corporation | Printhead for ink jet printing apparatus |
US5413227A (en) * | 1992-10-05 | 1995-05-09 | Midwest Research Institute | Improved vortex reactor system |
US5624555A (en) * | 1993-10-04 | 1997-04-29 | National Research Council Of Canada | Fluid fractionating, stacked permeable membrane assembly |
US5679580A (en) * | 1994-03-09 | 1997-10-21 | Midwest Research Institute | Rapid evaporation method for analysis |
GB9514541D0 (en) * | 1995-07-15 | 1995-09-13 | Ellis And Co Ltd S | Method and apparatus for contacting gas and liquid |
US5765591A (en) * | 1995-11-20 | 1998-06-16 | Argonaut Technologies, Inc. | Valve apparatus and method for distributing fluids |
US6720710B1 (en) * | 1996-01-05 | 2004-04-13 | Berkeley Microinstruments, Inc. | Micropump |
US5863502A (en) * | 1996-01-24 | 1999-01-26 | Sarnoff Corporation | Parallel reaction cassette and associated devices |
US6399023B1 (en) * | 1996-04-16 | 2002-06-04 | Caliper Technologies Corp. | Analytical system and method |
US5988603A (en) * | 1997-03-13 | 1999-11-23 | Midwest Research Institute | Level maintenance in cyclone contractors |
US5989402A (en) * | 1997-08-29 | 1999-11-23 | Caliper Technologies Corp. | Controller/detector interfaces for microfluidic systems |
US5900201A (en) * | 1997-09-16 | 1999-05-04 | Eastman Kodak Company | Binder coagulation casting |
US6145810A (en) * | 1998-04-14 | 2000-11-14 | Asepco, Inc. | Aseptic valve construction with diaphragm having straight neck |
US6830729B1 (en) * | 1998-05-18 | 2004-12-14 | University Of Washington | Sample analysis instrument |
US6158712A (en) * | 1998-10-16 | 2000-12-12 | Agilent Technologies, Inc. | Multilayer integrated assembly having an integral microminiature valve |
US7150994B2 (en) * | 1999-03-03 | 2006-12-19 | Symyx Technologies, Inc. | Parallel flow process optimization reactor |
CA2374423C (en) * | 1999-05-28 | 2013-04-09 | Cepheid | Apparatus and method for analyzing a liquid sample |
EP2309130B1 (en) * | 1999-06-28 | 2016-08-10 | California Institute of Technology | Microfabricated elastomeric valve and pump systems |
US6929030B2 (en) * | 1999-06-28 | 2005-08-16 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
US6875619B2 (en) * | 1999-11-12 | 2005-04-05 | Motorola, Inc. | Microfluidic devices comprising biochannels |
DE10011022A1 (de) * | 2000-03-07 | 2001-09-27 | Meinhard Knoll | Vorrichtung und Verfahren zur Durchführung von Synthesen, Analysen oder Transportvorgängen |
FR2818922B1 (fr) * | 2000-12-28 | 2003-10-03 | Atofina | Procede et dispositif pour la mise en oeuvre d'une reaction en milieu liquide avec degagement gazeux |
US6431976B1 (en) * | 2001-01-26 | 2002-08-13 | Visteon Global Technologies, Inc. | Rotary distribution chamber for selective distribution of a fluid |
CA2450676C (en) * | 2001-03-09 | 2010-03-30 | Biomicro Systems, Inc. | Method and system for microfluidic interfacing to arrays |
WO2002081729A2 (en) * | 2001-04-06 | 2002-10-17 | California Institute Of Technology | Nucleic acid amplification utilizing microfluidic devices |
US20030175947A1 (en) * | 2001-11-05 | 2003-09-18 | Liu Robin Hui | Enhanced mixing in microfluidic devices |
US6814337B2 (en) * | 2002-04-03 | 2004-11-09 | Ronald Anthony Schmaltz | Valve for controlling fluid flow through a tube, and related systems and methods |
US6752371B2 (en) * | 2002-06-19 | 2004-06-22 | Arichell Technologies, Inc. | Valve actuator having small isolated plunger |
US7125510B2 (en) * | 2002-05-15 | 2006-10-24 | Zhili Huang | Microstructure fabrication and microsystem integration |
US20040101444A1 (en) * | 2002-07-15 | 2004-05-27 | Xeotron Corporation | Apparatus and method for fluid delivery to a hybridization station |
US20050266582A1 (en) * | 2002-12-16 | 2005-12-01 | Modlin Douglas N | Microfluidic system with integrated permeable membrane |
US7296592B2 (en) * | 2003-09-16 | 2007-11-20 | Eksigent Technologies, Llc | Composite polymer microfluidic control device |
US20050232387A1 (en) * | 2004-04-20 | 2005-10-20 | Padgett Henry C | Microfluidic apparatus and method for synthesis of molecular imaging probes |
WO2006015308A2 (en) * | 2004-07-29 | 2006-02-09 | California Institute Of Technology | Modular microfluidic packaging system |
US7524672B2 (en) * | 2004-09-22 | 2009-04-28 | Sandia Corporation | Microfluidic microarray systems and methods thereof |
US20060204699A1 (en) * | 2004-12-08 | 2006-09-14 | George Maltezos | Parylene coated microfluidic components and methods for fabrication thereof |
GB2421202B (en) * | 2004-12-15 | 2009-12-09 | Syrris Ltd | Modular microfluidic system |
JP2006199276A (ja) * | 2004-12-24 | 2006-08-03 | Kobe Steel Ltd | 吸音構造 |
US7582263B2 (en) * | 2005-01-27 | 2009-09-01 | Octrolix Bv | Universal interface for a micro-fluidic chip |
CA2624243C (en) * | 2005-09-29 | 2013-12-31 | Siemens Medical Solutions Usa, Inc. | Microfluidic chip for synthesizing radioactively labeled molecules suitable for human imaging with positron emission tomography |
US7862000B2 (en) * | 2006-02-03 | 2011-01-04 | California Institute Of Technology | Microfluidic method and structure with an elastomeric gas-permeable gasket |
JP4322956B2 (ja) * | 2006-07-11 | 2009-09-02 | パナソニック株式会社 | 送液装置及び送液方法 |
US7741121B2 (en) * | 2006-08-24 | 2010-06-22 | Siemens Medical Solutions Usa, Inc. | System for purification and analysis of radiochemical products yielded by microfluidic synthesis devices |
US8071035B2 (en) * | 2007-04-12 | 2011-12-06 | Siemens Medical Solutions Usa, Inc. | Microfluidic radiosynthesis system for positron emission tomography biomarkers |
CA2684220A1 (en) * | 2007-04-12 | 2008-10-23 | Siemens Medical Solutions Usa, Inc. | Microfluidic radiosynthesis system for positron emission tomography biomarkers |
EP2183202A2 (en) * | 2007-07-20 | 2010-05-12 | Siemens Medical Solutions USA, Inc. | Microfluidic radiosynthesis of a radiolabeled compound using electrochemical trapping and release |
US7955567B2 (en) * | 2007-08-23 | 2011-06-07 | Igor Matveev | Triple helical flow vortex reactor improvements |
-
2009
- 2009-10-13 US US12/578,175 patent/US20100093098A1/en not_active Abandoned
- 2009-10-14 CA CA2740436A patent/CA2740436A1/en not_active Abandoned
- 2009-10-14 JP JP2011531262A patent/JP2012510353A/ja active Pending
- 2009-10-14 WO PCT/US2009/060583 patent/WO2010045283A2/en active Application Filing
- 2009-10-14 KR KR1020117011145A patent/KR20110084954A/ko active IP Right Grant
- 2009-10-14 EP EP09748173A patent/EP2352581A2/en not_active Withdrawn
-
2010
- 2010-12-15 US US12/968,466 patent/US20110098465A1/en not_active Abandoned
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS50106873A (ja) * | 1973-12-14 | 1975-08-22 | ||
WO2002089965A1 (de) * | 2001-05-07 | 2002-11-14 | INSTITUT FüR MIKROTECHNIK MAINZ GMBH | Verfahren und statischer mischer zum mischen mindestens zweier fluide |
US20040125689A1 (en) * | 2001-05-07 | 2004-07-01 | Wolfgang Ehrfeld | Method and statistical micromixer for mixing at least two liquids |
JP2005512760A (ja) * | 2001-05-07 | 2005-05-12 | ユーオーピー エルエルシー | 少なくとも2つの流体を混合及び反応させるための装置 |
JP2006528542A (ja) * | 2003-07-25 | 2006-12-21 | ウエラ アクチェンゲゼルシャフト | 静的ミクロミキサーを用いた抽出方法 |
JP2008522795A (ja) * | 2004-12-03 | 2008-07-03 | カリフォルニア インスティチュート オブ テクノロジー | 化学反応回路を有するマイクロ流体装置 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014087752A (ja) * | 2012-10-30 | 2014-05-15 | Toray Eng Co Ltd | マイクロリアクタシステムとそれを用いた化合物製造方法およびアルケニルリン化合物の製造方法 |
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