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上記目的を達成するために、この発明の第１の形態は、被検眼の視神経乳頭を含む眼底の部位の形態を表す３次元画像を受けてこれを処理する眼底画像処理装置であって、前記３次元画像に基づいて前記視神経乳頭の形態を表す断層像を形成する断層像形成部と、前記断層像を解析して当該断層像中の篩状板領域を特定する第１特定部と、前記断層像を解析して当該篩状板領域中の孔部領域を特定する第２特定部と、前記第２特定部により特定された前記孔部領域の前記篩状板領域における分布を表す分布情報を生成する生成部と、前記分布情報を表示する表示部とを備えることを特徴とする。
また、第２の形態は、前記分布情報は、前記孔部領域に含まれる複数の連結領域のサイズに基づく統計値、及び、前記篩状板領域に対する前記孔部領域の面積比の少なくともいずれかを含むことを特徴とする。
また、第３の形態は、前記表示部は、前記孔部領域と、前記篩状板領域における前記孔部領域以外の画像領域と、前記断層像における前記篩状板領域以外の画像領域とを互いに異なる表示態様として前記断層像を表示することを特徴とする。
また、第４の形態は、前記断層像形成部は、前記断層像として、前記視神経乳頭の深さ方向に直交しかつ深さ位置の異なる複数の水平断層像を形成し、前記第１特定部は、前記複数の水平断層像のそれぞれについて前記篩状板領域を特定し、前記第２特定部は、前記複数の水平断層像のそれぞれについて前記孔部領域を特定し、前記生成部は、前記篩状板領域の特定結果及び前記孔部領域の特定結果に基づいて前記異なる深さ位置のそれぞれの前記篩状板領域における前記孔部領域の水平分布を求め、更に、前記異なる深さ位置の前記水平分布に基づいて前記深さ方向における前記孔部領域の分布の変化を前記分布情報として求めることを特徴とする。
また、第５の形態は、前記分布の変化を表す前記分布情報が求められた前記複数の水平断層像に基づいて新たな３次元画像を形成する３次元画像形成部を備えることを特徴とする。
また、第６の形態は、前記断層像形成部は、前記新たな３次元画像に基づいて前記深さ方向に沿う垂直断層像を形成し、前記表示部は、前記垂直断層像を表示することを特徴とする。
また、第７の形態は、前記表示部は、前記分布情報に基づいて前記孔部領域の表示態様を変更して前記垂直断層像を表示することを特徴とする。
また、第８の形態は、前記断層像形成部は、前記３次元画像に基づいて前記深さ方向に沿う垂直断層像を形成し、前記第１特定部は、当該垂直断層像中の前記篩状板領域を特定し、前記第２特定部は、当該垂直断層像中の前記孔部領域を特定し、前記生成部は、前記篩状板領域の特定結果及び前記孔部領域の特定結果に基づいて前記篩状板領域における前記孔部領域の垂直分布を前記分布情報として求めることを特徴とする。
また、第９の形態は、前記第１特定部は、前記断層像の画素値に基づいて前記断層像における前記視神経乳頭に相当する乳頭領域と血管に相当する血管領域とを特定し、前記乳頭領域から前記血管領域を除いた領域を前記篩状板領域として特定することを特徴とする。
また、第１０の形態は、前記断層像は、輝度値を表す複数の画素が縦横に配列されてなる輝度画像であり、前記第２特定部は、前記断層像中の縦方向及び／又は横方向に沿う各画素列における画素の位置と輝度値とを対応付ける第１グラフを作成し、前記第１グラフの極大値を結ぶ極大包絡線と極小値を結ぶ極小包絡線とを求め、前記第１グラフの輝度値を表す座標軸方向において前記極大包絡線と前記極小包絡線との間を所定比で内分する第２グラフを求め、前記第２グラフよりも輝度値が小さい画素を前記孔部領域の画素として特定することを特徴とする。
また、第１１の形態は、光源からの光を信号光と参照光とに分割し、被検眼の眼底を経由した前記信号光と参照光路を経由した前記参照光とを重畳させて干渉光を生成して検出する光学系と、前記干渉光の検出結果に基づいて視神経乳頭を含む前記眼底の部位の形態を表す３次元画像を形成する形成部と、前記３次元画像に基づいて前記視神経乳頭の形態を表す断層像を形成する断層像形成部と、前記断層像を解析して当該断層像中の篩状板領域を特定する第１特定部と、前記断層像を解析して当該篩状板領域中の孔部領域を特定する第２特定部と、前記第２特定部により特定された前記孔部領域の前記篩状板領域における分布を表す分布情報を生成する生成部と、前記分布情報を表示する表示部と、を備えることを特徴とする眼底観察装置である。
In order to achieve the above object, a first aspect of the present invention is a fundus image processing apparatus that receives and processes a three-dimensional image representing a form of a fundus region including an optic nerve head of an eye to be examined, A tomographic image forming unit that forms a tomographic image representing the form of the optic nerve head based on a three-dimensional image, a first specifying unit that analyzes the tomographic image and identifies a phloem plate region in the tomographic image, and A second specifying unit that analyzes a tomographic image and specifies a hole region in the sieve plate region, and distribution information that represents a distribution in the sieve plate region of the hole region specified by the second specifying unit And a display unit for displaying the distribution information.
In the second embodiment, the distribution information is at least one of a statistical value based on the sizes of a plurality of connected regions included in the hole region, and an area ratio of the hole region to the sieve plate region. It is characterized by including.
In the third embodiment, the display unit includes the hole region, an image region other than the hole region in the sieve plate region, and an image region other than the sieve plate region in the tomographic image. The tomographic images are displayed as different display modes.
According to a fourth aspect, the tomographic image forming unit forms, as the tomographic image, a plurality of horizontal tomographic images orthogonal to the depth direction of the optic nerve head and having different depth positions, and the first specifying unit Specifies the sieving plate region for each of the plurality of horizontal tomographic images, the second specifying unit specifies the hole region for each of the plurality of horizontal tomographic images, and the generation unit includes the Based on the identification result of the sieve plate region and the specification result of the hole region, the horizontal distribution of the hole region in each of the sieve plate regions at the different depth positions is obtained, and further, the different depth position A change in the distribution of the hole region in the depth direction is obtained as the distribution information based on the horizontal distribution.
Further, the fifth aspect includes a three-dimensional image forming unit that forms a new three-dimensional image based on the plurality of horizontal tomographic images from which the distribution information representing the change in the distribution is obtained. .
In the sixth embodiment, the tomographic image forming unit forms a vertical tomographic image along the depth direction based on the new three-dimensional image, and the display unit displays the vertical tomographic image. It is characterized by.
Further, the seventh mode is characterized in that the display unit displays the vertical tomographic image by changing a display mode of the hole region based on the distribution information.
According to an eighth aspect, the tomographic image forming unit forms a vertical tomographic image along the depth direction based on the three-dimensional image, and the first specifying unit is configured to use the sieve in the vertical tomographic image. The second specifying unit specifies the hole region in the vertical tomographic image, and the generation unit determines the result of specifying the sieve plate region and the specifying result of the hole region. Based on this, the vertical distribution of the hole region in the sieve plate region is obtained as the distribution information.
In the ninth aspect, the first specifying unit specifies a papillary region corresponding to the optic nerve head and a blood vessel region corresponding to a blood vessel in the tomographic image based on a pixel value of the tomographic image, and the papillae A region obtained by removing the blood vessel region from the region is specified as the sieve plate region.
In the tenth aspect, the tomographic image is a luminance image in which a plurality of pixels representing luminance values are arranged vertically and horizontally, and the second specifying unit includes a vertical direction and / or a horizontal direction in the tomographic image. A first graph that associates a pixel position and a luminance value in each pixel row along the direction is created, a maximum envelope connecting the maximum values of the first graph and a minimum envelope connecting the minimum values are obtained, and the first A second graph that internally divides the maximum envelope and the minimum envelope by a predetermined ratio in the coordinate axis direction representing the luminance value of the graph is obtained, and pixels having a luminance value smaller than that of the second graph are determined as the hole region. It is specified as a pixel.
In the eleventh aspect, the light from the light source is divided into signal light and reference light, and the signal light passing through the fundus of the eye to be examined and the reference light passing through the reference light path are superimposed to generate interference light. An optical system that generates and detects; a forming unit that forms a three-dimensional image representing a form of the fundus portion including the optic papilla based on the detection result of the interference light; and the optic papilla based on the three-dimensional image A tomographic image forming unit for forming a tomographic image representing the form of the first image, a first specifying unit for analyzing the tomographic image to identify a sifter-like plate region in the tomographic image, A second specifying unit that specifies a hole region in the plate region; a generating unit that generates distribution information representing a distribution in the sieve plate region of the hole region specified by the second specifying unit; and the distribution A fundus observation device comprising: a display unit configured to display information; A.
Claims (11)
前記３次元画像に基づいて前記視神経乳頭の形態を表す断層像を形成する断層像形成部と、
前記断層像を解析して当該断層像中の篩状板領域を特定する第１特定部と、
前記断層像を解析して当該篩状板領域中の孔部領域を特定する第２特定部と、
前記第２特定部により特定された前記孔部領域の前記篩状板領域における分布を表す分布情報を生成する生成部と、
前記分布情報を表示する表示部と、
を備えることを特徴とする眼底画像処理装置。 A fundus image processing apparatus that receives and processes a three-dimensional image representing a form of a fundus region including an optic disc of an eye to be examined,
A tomographic image forming unit for forming a tomographic image representing the form of the optic disc based on the three-dimensional image;
A first specifying unit for analyzing the tomographic image and specifying a sieve plate region in the tomographic image;
A second specifying unit for analyzing the tomographic image and specifying a hole region in the sieve plate region;
A generating unit that generates distribution information representing a distribution in the sieve plate region of the hole region specified by the second specifying unit;
A display unit for displaying the distribution information;
A fundus image processing apparatus comprising:
ことを特徴とする請求項１に記載の眼底画像処理装置。 The distribution information includes at least one of a statistical value based on the size of a plurality of connected regions included in the hole region, and an area ratio of the hole region to the sieve plate region,
The fundus image processing apparatus according to claim 1.
ことを特徴とする請求項１又は請求項２に記載の眼底画像処理装置。 The display unit includes the tomographic image as a display mode in which the hole region, an image region other than the hole region in the sieve plate region, and an image region other than the sieve plate region in the tomographic image are different from each other. Display,
The fundus image processing apparatus according to claim 1, wherein the fundus image processing apparatus is provided.
前記第１特定部は、前記複数の水平断層像のそれぞれについて前記篩状板領域を特定し、
前記第２特定部は、前記複数の水平断層像のそれぞれについて前記孔部領域を特定し、
前記生成部は、前記篩状板領域の特定結果及び前記孔部領域の特定結果に基づいて前記異なる深さ位置のそれぞれの前記篩状板領域における前記孔部領域の水平分布を求め、更に、前記異なる深さ位置の前記水平分布に基づいて前記深さ方向における前記孔部領域の分布の変化を前記分布情報として求める、
ことを特徴とする請求項１〜請求項３のいずれか一項に記載の眼底画像処理装置。 The tomographic image forming unit forms a plurality of horizontal tomographic images orthogonal to the depth direction of the optic nerve head and having different depth positions as the tomographic image,
The first specifying unit specifies the sieve plate region for each of the plurality of horizontal tomographic images,
The second specifying unit specifies the hole region for each of the plurality of horizontal tomographic images,
The generating unit obtains a horizontal distribution of the hole region in each of the sieve plate regions at the different depth positions based on the specification result of the sieve plate region and the specification result of the hole region, Based on the horizontal distribution of the different depth positions, to determine the change in the distribution of the hole region in the depth direction as the distribution information,
The fundus image processing apparatus according to any one of claims 1 to 3, wherein
ことを特徴とする請求項４に記載の眼底画像処理装置。 A three-dimensional image forming unit that forms a new three-dimensional image based on the plurality of horizontal tomographic images for which the distribution information representing the change in the distribution is obtained;
The fundus image processing apparatus according to claim 4.
前記表示部は、前記垂直断層像を表示する、
ことを特徴とする請求項５に記載の眼底画像処理装置。 The tomographic image forming unit forms a vertical tomographic image along the depth direction based on the new three-dimensional image,
The display unit displays the vertical tomographic image;
The fundus image processing apparatus according to claim 5.
ことを特徴とする請求項６に記載の眼底画像処理装置。 The display unit displays the vertical tomographic image by changing a display mode of the hole region based on the distribution information.
The fundus image processing apparatus according to claim 6.
前記第１特定部は、当該垂直断層像中の前記篩状板領域を特定し、
前記第２特定部は、当該垂直断層像中の前記孔部領域を特定し、
前記生成部は、前記篩状板領域の特定結果及び前記孔部領域の特定結果に基づいて前記篩状板領域における前記孔部領域の垂直分布を前記分布情報として求める、
ことを特徴とする請求項１〜請求項３のいずれか一項に記載の眼底画像処理装置。 The tomographic image forming unit forms a vertical tomographic image along the depth direction based on the three-dimensional image;
The first specifying unit specifies the sieve plate region in the vertical tomographic image,
The second specifying portion specifies the hole region in the vertical tomographic image,
The generation unit obtains, as the distribution information, a vertical distribution of the hole region in the sieve plate region based on the specification result of the sieve plate region and the specification result of the hole region.
The fundus image processing apparatus according to any one of claims 1 to 3, wherein
ことを特徴とする請求項１〜請求項８のいずれか一項に記載の眼底画像処理装置。 The first specifying unit specifies a papillary region corresponding to the optic disc and a blood vessel region corresponding to a blood vessel in the tomographic image based on a pixel value of the tomographic image, and removes the blood vessel region from the papillary region. Identifying the region as the sieve plate region,
The fundus image processing apparatus according to any one of claims 1 to 8, wherein
前記第２特定部は、前記断層像中の縦方向及び／又は横方向に沿う各画素列における画素の位置と輝度値とを対応付ける第１グラフを作成し、前記第１グラフの極大値を結ぶ極大包絡線と極小値を結ぶ極小包絡線とを求め、前記第１グラフの輝度値を表す座標軸方向において前記極大包絡線と前記極小包絡線との間を所定比で内分する第２グラフを求め、前記第２グラフよりも輝度値が小さい画素を前記孔部領域の画素として特定する、
ことを特徴とする請求項１〜請求項９のいずれか一項に記載の眼底画像処理装置。 The tomographic image is a luminance image in which a plurality of pixels representing luminance values are arranged vertically and horizontally,
The second specifying unit creates a first graph that associates a pixel position and a luminance value in each pixel column along the vertical direction and / or the horizontal direction in the tomographic image, and connects the maximum values of the first graph. A second graph that obtains a minimum envelope connecting a maximum envelope and a minimum value and internally divides the maximum envelope and the minimum envelope by a predetermined ratio in the coordinate axis direction representing the luminance value of the first graph. Obtaining a pixel having a luminance value smaller than that of the second graph as a pixel of the hole region;
The fundus image processing apparatus according to any one of claims 1 to 9, wherein
前記干渉光の検出結果に基づいて視神経乳頭を含む前記眼底の部位の形態を表す３次元画像を形成する形成部と、
前記３次元画像に基づいて前記視神経乳頭の形態を表す断層像を形成する断層像形成部と、
前記断層像を解析して当該断層像中の篩状板領域を特定する第１特定部と、
前記断層像を解析して当該篩状板領域中の孔部領域を特定する第２特定部と、
前記第２特定部により特定された前記孔部領域の前記篩状板領域における分布を表す分布情報を生成する生成部と、
前記分布情報を表示する表示部と、
を備えることを特徴とする眼底観察装置。 An optical system that divides light from a light source into signal light and reference light, and generates and detects interference light by superimposing the signal light passing through the fundus of the eye to be examined and the reference light passing through a reference light path; ,
A forming unit that forms a three-dimensional image representing the form of the fundus region including the optic disc based on the detection result of the interference light;
A tomographic image forming unit for forming a tomographic image representing the form of the optic disc based on the three-dimensional image;
A first specifying unit for analyzing the tomographic image and specifying a sieve plate region in the tomographic image;
A second specifying unit for analyzing the tomographic image and specifying a hole region in the sieve plate region;
A generating unit that generates distribution information representing a distribution in the sieve plate region of the hole region specified by the second specifying unit;
A display unit for displaying the distribution information;
A fundus oculi observation device comprising:
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| US13/806,326 US9275283B2 (en) | 2010-11-09 | 2011-09-14 | Fundus image processing apparatus and fundus observation apparatus |
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| DE102005034332A1 (en) * | 2005-07-22 | 2007-01-25 | Carl Zeiss Meditec Ag | Apparatus and method for observation, documentation and / or diagnosis of the ocular fundus |
| US7290880B1 (en) * | 2005-07-27 | 2007-11-06 | Visionsense Ltd. | System and method for producing a stereoscopic image of an eye fundus |
| JP5095167B2 (en) | 2006-09-19 | 2012-12-12 | 株式会社トプコン | Fundus observation apparatus, fundus image display apparatus, and fundus observation program |
| EP1950526B1 (en) * | 2007-01-26 | 2010-03-10 | Kabushiki Kaisha TOPCON | Optical image measurement device |
| JP2008259544A (en) | 2007-04-10 | 2008-10-30 | Topcon Corp | Slit lamp |
| US7992999B2 (en) * | 2008-04-23 | 2011-08-09 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Automated assessment of optic nerve head with spectral domain optical coherence tomography |
| WO2009139722A1 (en) * | 2008-05-14 | 2009-11-19 | Agency For Science, Technology And Research | Automatic cup-to-disc ratio measurement system |
| EP2335030A4 (en) * | 2008-06-18 | 2014-05-07 | Eyelab Group Llc | System and method for determining volume-related parameters of ocular and other biological tissues |
| EP2312994B1 (en) * | 2008-07-18 | 2021-01-27 | Doheny Eye Institute | Optical coherence tomography - based ophthalmic testing systems |
| US8137271B2 (en) | 2009-03-04 | 2012-03-20 | Heidelberg Engineering Gmbh | System and method for assessing risk of glaucoma onset |
| JP5437755B2 (en) * | 2009-04-15 | 2014-03-12 | 株式会社トプコン | Fundus observation device |
| JP5415812B2 (en) * | 2009-04-17 | 2014-02-12 | 株式会社トプコン | Optical image measuring device and control method thereof |
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2010
- 2010-11-09 JP JP2010250786A patent/JP5628636B2/en active Active
-
2011
- 2011-09-14 EP EP11839879.1A patent/EP2638848B1/en active Active
- 2011-09-14 WO PCT/JP2011/005169 patent/WO2012063390A1/en active Application Filing
- 2011-09-14 US US13/806,326 patent/US9275283B2/en active Active
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