JP2012010830A - Medication device - Google Patents

Medication device Download PDF

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JP2012010830A
JP2012010830A JP2010148590A JP2010148590A JP2012010830A JP 2012010830 A JP2012010830 A JP 2012010830A JP 2010148590 A JP2010148590 A JP 2010148590A JP 2010148590 A JP2010148590 A JP 2010148590A JP 2012010830 A JP2012010830 A JP 2012010830A
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storage space
wall
container body
pressure
dosing device
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JP5424998B2 (en
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Shigeo Iizuka
茂雄 飯塚
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Yoshino Kogyosho Co Ltd
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Yoshino Kogyosho Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

PROBLEM TO BE SOLVED: To provide a medication device to be directly pressed on skin etc. to apply medicine, while preventing an increase in pressure when the volume of an internal space decreases.SOLUTION: The medication device includes: a container body 1 for forming a partitioning recess 1b in an opening 1a to form a space M for housing medicine, and a hermetic sealing wall for closing the opening 1a to close the housing space M. A pointed end 3 for drilling the hermetic sealing wall 2 by crushing the container body 1 to discharge the medicine in the housing space M is provided on the housing space M. A pressure absorbing wall 1c which bulges upon an increase in pressure of the housing space M with crushing of the container body 1 to suppress an increase in pressure of the housing space M is provided on the container body 1.

Description

本発明は、薬剤を内容物として収容した容器を皮膚や粘膜等に直接押しつけて、中身の薬剤を投与するのに好適な投薬デバイスに関する。   The present invention relates to a dosing device suitable for administering a drug contained inside by directly pressing a container containing the drug as contents onto skin, mucous membrane or the like.

従来より、容器の内部空間に薬剤と針状の部材とを共に収容し、この容器を皮膚や粘膜等に直接押しつけて、針状の部材で容器の封止フィルムの穿孔と皮膚への穿刺を行い、中身の薬剤を身体に浸透させる投薬デバイスが知られている。（例えば特許文献１参照）   Conventionally, a medicine and a needle-shaped member are housed together in the internal space of the container, and the container is pressed directly against the skin, mucous membrane, etc., and the needle-shaped member punctures the sealing film of the container and punctures the skin. Dosing devices that perform and allow the contents of drugs to penetrate the body are known. (For example, see Patent Document 1)

特開２００４−６５７７５号公報JP 2004-65775 A

ところで、上記のような構成の投薬デバイスは、容器の押し込みによって内部空間の容積は減る一方、この空間の内部圧力は上昇する。この為、封止フィルムが穿孔されると、加圧された薬剤が身体に浸透する前に容器から流れ出し、必要量の薬剤を投与できない懸念があった。また、薬剤の浸透速度が予定以上に速くなってしまう懸念もあった。   By the way, in the dosing device configured as described above, the volume of the internal space is reduced by pushing the container, while the internal pressure of the space is increased. For this reason, when the sealing film is perforated, there is a concern that the pressurized medicine flows out of the container before penetrating into the body and the necessary amount of medicine cannot be administered. There was also a concern that the penetration rate of the drug would be faster than expected.

本発明の課題は、内部空間に薬剤と針状の部材とを共に収容する容器を、皮膚や粘膜等に直接押しつけて薬剤を投与する場合に生じていた、上記の如き従来の不具合を解消できる投薬デバイスを提案するところにある。   An object of the present invention is to solve the above-mentioned conventional problems that occur when a drug is administered by directly pressing a container that contains both a drug and a needle-shaped member in the internal space against the skin, mucous membrane, and the like. Proposed dosing device.

本発明は、開口部の内側に区画凹所を形成し該区画凹所を薬剤の収納空間とする容器本体と、該開口部を封止して該収納空間を閉鎖する密閉壁とを備え、前記収納空間に、前記容器本体の押し潰しにより前記密閉壁を穿孔して該収納空間の薬剤を注出する尖頭体を設けた投薬デバイスであって、
前記容器本体に、該容器本体の押し潰しに伴う収納空間の圧力上昇にて膨出し該収納空間の圧力上昇を抑制する圧力吸収壁を設けたことを特徴とする投薬デバイスである。 The present invention comprises a container body that forms a compartment recess inside the opening and uses the compartment recess as a medicine storage space, and a sealing wall that seals the opening and closes the storage space, In the storage space, a dosing device provided with a pointed body that pierces the sealed wall by crushing the container body to pour out the medicine in the storage space,
The dosing device is characterized in that the container body is provided with a pressure absorbing wall that bulges due to an increase in pressure in the storage space accompanying the crushing of the container body and suppresses the pressure increase in the storage space.

前記圧力吸収壁は、前記収納空間に向けて突出する凸状体であることが望ましい。   It is desirable that the pressure absorbing wall is a convex body protruding toward the storage space.

前記尖頭体を前記収納空間に保持する支持部材を設け、
前記支持部材が、該尖頭体を固定するベースと、該ベースと一体連結し前記容器本体及び前記密閉壁の少なくとも一方に弾性支持される弾性片とを備えることが望ましい。 A support member for holding the pointed body in the storage space is provided,
The support member preferably includes a base that fixes the pointed body, and an elastic piece that is integrally connected to the base and elastically supported by at least one of the container body and the sealing wall.

前記尖頭体を、前記区画凹所の壁部に直接設けることが望ましい。   It is desirable that the pointed body is directly provided on the wall of the partition recess.

容器本体に、この容器本体の押し潰しに伴う収納空間の圧力上昇にて膨出する圧力吸収壁を設けたので、収納空間の圧力上昇を抑制することが可能となり、密閉壁を穿孔する際の薬剤の漏れ出しを効果的に抑制することができる。   Since the container body is provided with a pressure absorbing wall that swells due to an increase in the pressure of the storage space accompanying the crushing of the container body, it is possible to suppress an increase in the pressure of the storage space and Drug leakage can be effectively suppressed.

圧力吸収壁を、収納空間に向けて突出する凸状体として設けたので、簡易な構成により収納空間の圧力上昇を吸収することができる。   Since the pressure absorption wall is provided as a convex body that protrudes toward the storage space, the pressure increase in the storage space can be absorbed with a simple configuration.

尖頭体を保持する支持部材が、この尖頭体を保持するベースと、このベースと一体連結し容器本体及び密閉壁の少なくとも一方に弾性支持される弾性片とを備えてなるので、容器の押し潰し前における尖頭体と密閉壁との接触が防止され、容器の不用意な開栓が阻止される。また押し潰しの際には弾性変形するので、強い力で押し込まなくても密閉壁を穿孔することができる。   The support member for holding the pointed body includes a base for holding the pointed body, and an elastic piece integrally connected to the base and elastically supported by at least one of the container body and the sealing wall. Contact between the pointed body and the sealing wall before crushing is prevented, and inadvertent opening of the container is prevented. Further, since it is elastically deformed during crushing, the sealed wall can be perforated without being pushed in with a strong force.

尖頭体を、区画凹所の壁部に直接設けたので、部材を減らして構成を簡略化することができる。   Since the pointed body is provided directly on the wall of the partition recess, the configuration can be simplified by reducing the number of members.

本発明に従う投薬デバイスの実施の形態を示した図であり、（ａ）は容器本体を押し潰す前の斜視図であり、（ｂ）は（ａ）の中央を切断して内部構造を示した斜視図である。It is the figure which showed embodiment of the dosing device according to this invention, (a) is a perspective view before crushing a container main body, (b) cut | disconnected the center of (a) and showed the internal structure It is a perspective view. 図１に示す投薬デバイスの容器本体の断面図である。It is sectional drawing of the container main body of the dosing device shown in FIG. 図２に示す投薬デバイスの容器本体を押し潰した後の断面図である。FIG. 3 is a cross-sectional view after the container body of the dosing device shown in FIG. 2 has been crushed. 図１に示す投薬デバイスの容器本体を押し潰した後の図であり、（ａ）は斜視図であり、（ｂ）は（ａ）の中央を切断して内部構造を示した斜視図である。It is the figure after crushing the container main body of the dosing device shown in FIG. 1, (a) is a perspective view, (b) is the perspective view which cut | disconnected the center of (a) and showed the internal structure. . 本発明にしたがう投薬デバイスの他の実施の形態を示した図であり、中央で切断した断面図である。FIG. 6 is a view showing another embodiment of the dosing device according to the present invention, and is a cross-sectional view cut at the center.

以下、図面を参照して、本発明をより具体的に説明する。
図１は、本発明に従う投薬デバイスの実施の形態を示した図であり、（ａ）は容器本体を押し潰す前の斜視図であり、（ｂ）は（ａ）の中央を切断して内部構造を示した図であり、図２は、図１に示す投薬デバイスの容器本体の断面図である。 Hereinafter, the present invention will be described more specifically with reference to the drawings.
FIG. 1 is a view showing an embodiment of a dosing device according to the present invention, in which (a) is a perspective view before crushing a container body, and (b) is a cross-sectional view taken along the center of (a). FIG. 2 is a cross-sectional view of the container body of the dosing device shown in FIG.

図１において、１は投薬デバイスの本体部となる容器本体である。容器本体１は、開口部１ａの内側に区画凹所１ｂを有しており、この区画凹所１ｂの内側に薬剤等の内容物ｍ（液体、粘性体、粉体など）を収容する収納空間Ｍを形成している。図示の例で容器本体１は、区画凹所１ｂとは逆向きであって、収納空間Ｍに向けて突出する凸状体（圧力吸収壁）１ｃを備えている。容器本体１は、押圧力を加える前は区画凹所１ｂの形状を保持することが可能であって、この区画凹所１ｂを押し込んだ時には潰すことができる、薄肉のプラスチック等によって形成されている。   In FIG. 1, 1 is a container main body which becomes a main body part of a dosing device. The container body 1 has a partition recess 1b inside the opening 1a, and a storage space for storing the contents m (liquid, viscous material, powder, etc.) such as a medicine inside the partition recess 1b. M is formed. In the illustrated example, the container main body 1 includes a convex body (pressure absorbing wall) 1c that is opposite to the partition recess 1b and protrudes toward the storage space M. The container body 1 is formed of a thin-walled plastic or the like that can hold the shape of the compartment recess 1b before applying a pressing force and can be crushed when the compartment recess 1b is pushed. .

２は、収納空間Ｍに内容物ｍを収容した後、開口部１ａを取り囲むフランジと接着剤等により接着され、収納空間Ｍを閉鎖する密閉壁である。密閉壁２は、後述する尖頭体により孔が形成できるようにフィルムやシート等によって形成されている。   Reference numeral 2 denotes a hermetically sealed wall that closes the storage space M after the content m is stored in the storage space M and is bonded to the flange surrounding the opening 1a with an adhesive or the like. The sealing wall 2 is formed of a film, a sheet, or the like so that a hole can be formed by a pointed body described later.

３は、収納空間Ｍにおいて、尖った側を密閉壁２に向ける尖頭体である。尖頭体３は、密閉壁２を穿孔後、皮膚や粘膜等に僅かに刺さるものであり、微小な針となっている。   Reference numeral 3 denotes a pointed body with the sharp side facing the sealed wall 2 in the storage space M. The pointed body 3 is slightly pierced into the skin or mucous membrane after the sealed wall 2 is perforated, and is a fine needle.

４は、尖頭体３を収納空間Ｍに保持する支持部材である。支持部材４は、尖頭体３を保持するベース４ａと、ベース４ａと一体連結するとともに、容器本体１及び密閉壁２の少なくとも一方と接続部４ｃを介して連結して、尖頭体３を弾性支持する弾性片４ｂとを備えている。尖頭体３は、弾性片４ｂによって、区画凹所１ｂの直下において密閉壁２から間隔をあけて配置されている。図２に示す例で尖頭体３は、１つの弾性片４ｂが密閉壁２と連結する片持ち支持されたものとして示しているが、２つの弾性片４ｂで両端支持するようにしてもよい。また尖頭体３は、図示の例では複数設けた例を示したが、狭い範囲に投与する場合には１つであってもよい。   Reference numeral 4 denotes a support member that holds the pointed body 3 in the storage space M. The support member 4 is integrally connected to the base 4a for holding the pointed body 3 and the base 4a, and is connected to at least one of the container main body 1 and the sealing wall 2 via the connecting portion 4c, so And an elastic piece 4b for elastic support. The pointed body 3 is arranged at an interval from the sealing wall 2 immediately below the partition recess 1b by an elastic piece 4b. In the example shown in FIG. 2, the pointed body 3 is shown as being supported in a cantilever manner in which one elastic piece 4 b is connected to the sealing wall 2, but may be supported at both ends by two elastic pieces 4 b. . In the illustrated example, a plurality of the cusps 3 are provided. However, when the administration is performed in a narrow range, one pointed body 3 may be provided.

上記のような構成となる投薬デバイスを用いて薬剤を投与するには、図３に示すように密閉壁２を皮膚Ｓにあてがい、容器本体１の区画凹所１ｂを押圧する。この押圧により区画凹所１ｂは次第に押し潰され、密閉壁２を穿孔するとともに皮膚Ｓを穿刺して、最終的に変形した区画凹所１ｂ´となる（図３、図４（ａ）、（ｂ）参照）。この押し潰しの最中において、収納空間Ｍの容積は減っていくとともに内部圧力は上昇していくが、凸状体１ｃは、上昇する内部圧力に応じて収納空間Ｍの反対側に向かって膨出して、凸状体１ｃ´に変形する。このため区画凹所１ｂを押し潰しても、収納空間Ｍの圧力上昇を抑制することができる。また、区画凹所１ｂの押し潰しに伴い、収納空間Ｍの圧力が実質的に一定に保持されるように設定することが好ましい。また密閉壁２が穿孔されるまでは、区画凹所１ｂが変形しても収納空間Ｍは密閉したまま保たれるので、内容物ｍや尖頭体３が汚染されるおそれがない。   In order to administer the drug using the dispensing device having the above-described configuration, the sealing wall 2 is applied to the skin S as shown in FIG. 3 and the partition recess 1b of the container body 1 is pressed. By this pressing, the partition recess 1b is gradually crushed, and the sealed wall 2 is pierced and the skin S is punctured, resulting in a finally deformed partition recess 1b ′ (FIG. 3, FIG. 4 (a), ( b)). During the crushing, the volume of the storage space M decreases and the internal pressure increases, but the convex body 1c swells toward the opposite side of the storage space M according to the rising internal pressure. And is transformed into a convex body 1c ′. For this reason, even if it crushes the division recess 1b, the pressure rise of the storage space M can be suppressed. Moreover, it is preferable to set so that the pressure of the storage space M is kept substantially constant as the partition recess 1b is crushed. Further, until the sealed wall 2 is perforated, the storage space M is kept sealed even if the partition recess 1b is deformed, so that the contents m and the pointed body 3 are not likely to be contaminated.

図示の例で圧力吸収壁は、収納空間Ｍに向けて突出する凸状体１ｃとして示したが、周囲の区画凹所１ｂと同一形状のまま部分的に厚みを薄くしたり、材料を部分的に弾性変形しやすいものに変更したりして、この部位が圧力上昇に応じて膨出するようにしてもよい。   In the illustrated example, the pressure absorbing wall is shown as a convex body 1c that protrudes toward the storage space M. However, the pressure absorbing wall is partially thinned or partially made of the same material as the surrounding partition recess 1b. Alternatively, it may be changed to one that is easily elastically deformed, and this portion may bulge in response to an increase in pressure.

密閉壁２の外側（収納空間Ｍとは反対側）に、皮膚Ｓに貼り付けるための粘着体を設けてもよい。これにより容器本体１を押圧する際に投薬デバイスがずれてしまうことがなく、皮膚等の不用意な傷つけを有効に防止し得ることができ、また投与中は投薬デバイスが皮膚Ｓから浮き上がることが無いので、薬剤を漏れなく浸透させることが可能となる。   You may provide the adhesive body for affixing on the skin S on the outer side (opposite side of the storage space M) of the sealing wall 2. FIG. As a result, the dosing device is not displaced when the container body 1 is pressed, and inadvertent damage to the skin or the like can be effectively prevented, and the dosing device may be lifted from the skin S during administration. Since it does not exist, it becomes possible to penetrate the drug without leakage.

密閉壁２の内側（収納空間Ｍと同じ側）に、粘着体を設けてもよい。これにより区画凹所１ｂを押圧した際に尖頭体３のベース４ａがこの粘着体に貼り付いて、押圧する指を離しても尖頭体３が皮膚に穿刺して薬剤の浸透が継続でき、必要とする薬剤を最後まで浸透させることができる。   An adhesive body may be provided inside the sealed wall 2 (the same side as the storage space M). Thereby, when pressing the partition recess 1b, the base 4a of the cusp 3 is adhered to this adhesive body, and even if the finger to be pressed is released, the cusp 3 punctures the skin and the penetration of the drug can be continued. , You can penetrate the medicine you need to the end.

尖頭体３を、図５に示すように区画凹所１ｂの壁部に接着或いは溶着等により直接設けてもよい。これにより弾性片４ｂ等を削減できるので、構成を簡略化することができる。   As shown in FIG. 5, the pointed body 3 may be directly provided on the wall portion of the partition recess 1b by adhesion or welding. As a result, the elastic pieces 4b and the like can be reduced, so that the configuration can be simplified.

本発明によれば、内部空間に薬剤と針状の部材とを共に収容する容器を、皮膚や粘膜等に直接押しつけて薬剤を投与する投薬デバイスに関し、内部空間の容積の減少に伴う圧力の上昇を抑制することが可能な投薬デバイスを提供できる。   The present invention relates to a dosing device that administers a drug by directly pressing a container containing both a drug and a needle-shaped member in the internal space against the skin, mucous membrane, etc. Can be provided.

１ 容器本体
１ａ 開口部
１ｂ 区画凹所
１ｃ 凸状体（圧力吸収壁）
２ 密閉壁
３ 尖頭体
４ 支持部材
４ａ ベース
４ｂ 弾性片
４ｃ 接続部
ｍ 内容物
Ｍ 収納空間
Ｓ 皮膚 DESCRIPTION OF SYMBOLS 1 Container body 1a Opening part 1b Compartment recess 1c Convex body (pressure absorption wall)
2 Sealing wall 3 Pointed body 4 Support member 4a Base 4b Elastic piece 4c Connection part m Contents M Storage space S Skin

Claims (4)

開口部の内側に区画凹所を形成し該区画凹所を薬剤の収納空間とする容器本体と、該開口部を封止して該収納空間を閉鎖する密閉壁とを備え、前記収納空間に、前記容器本体の押し潰しにより前記密閉壁を穿孔して該収納空間の薬剤を注出する尖頭体を設けた投薬デバイスであって、
前記容器本体に、該容器本体の押し潰しに伴う収納空間の圧力上昇にて膨出し該収納空間の圧力上昇を抑制する圧力吸収壁を設けたことを特徴とする投薬デバイス。 A container body that forms a compartment recess inside the opening and uses the compartment recess as a medicine storage space; and a sealing wall that seals the opening and closes the storage space. A dosing device provided with a pointed body that pierces the sealed wall by crushing the container body to pour out the medicine in the storage space,
A dosing device, wherein the container body is provided with a pressure absorbing wall that bulges due to an increase in pressure in the storage space accompanying the crushing of the container body and suppresses the pressure increase in the storage space. 前記圧力吸収壁は、前記収納空間に向けて突出する凸状体である請求項１記載の投薬デバイス。   The dosing device according to claim 1, wherein the pressure absorption wall is a convex body protruding toward the storage space. 前記尖頭体を前記収納空間に保持する支持部材を設け、
前記支持部材が、該尖頭体を固定するベースと、該ベースと一体連結し前記容器本体及び前記密閉壁の少なくとも一方に弾性支持される弾性片とを備える請求項１又は２記載の投薬デバイス。 A support member for holding the pointed body in the storage space is provided,
The dosing device according to claim 1, wherein the support member includes a base that fixes the pointed body, and an elastic piece that is integrally connected to the base and elastically supported by at least one of the container body and the sealing wall. . 前記尖頭体を、前記区画凹所の壁部に直接設けた請求項１又は２記載の投薬デバイス。   The dosing device according to claim 1 or 2, wherein the pointed body is provided directly on the wall of the compartment recess.
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