JP2011502579A5 - 多孔質貯蔵部および非ポリマー拡散層を備えた内部人工器官及びその形成方法 - Google Patents
多孔質貯蔵部および非ポリマー拡散層を備えた内部人工器官及びその形成方法 Download PDFInfo
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- JP2011502579A5 JP2011502579A5 JP2010532278A JP2010532278A JP2011502579A5 JP 2011502579 A5 JP2011502579 A5 JP 2011502579A5 JP 2010532278 A JP2010532278 A JP 2010532278A JP 2010532278 A JP2010532278 A JP 2010532278A JP 2011502579 A5 JP2011502579 A5 JP 2011502579A5
- Authority
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- Japan
- Prior art keywords
- porous layer
- endoprosthesis
- ceramic
- pore diameter
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920000642 polymer Polymers 0.000 title claims 2
- 238000009792 diffusion process Methods 0.000 title 1
- 239000000919 ceramic Substances 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 4
- 229940079593 drugs Drugs 0.000 claims 4
- 239000011148 porous material Substances 0.000 claims 4
- 229910052751 metal Inorganic materials 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- YJZATOSJMRIRIW-UHFFFAOYSA-N [Ir]=O Chemical compound [Ir]=O YJZATOSJMRIRIW-UHFFFAOYSA-N 0.000 claims 1
- 229910000457 iridium oxide Inorganic materials 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
Claims (11)
- 表面と、
前記表面上において第1セラミックから形成された第1多孔質層であって薬剤を含有する第1多孔質層と、
前記第1多孔質層上において第2セラミックまたは金属から形成された第2多孔質層と、を備え、
前記第2多孔質層は前記第1多孔質層よりも低い空隙率を有するとともに前記第2多孔質層の細孔径は、前記第1多孔質層の細孔径よりも小さい、内部人工器官。 - 前記第2多孔質層の厚さは、10〜500nmである、請求項1に記載の内部人工器官。
- 前記第1多孔質層の厚さは、0.1〜3μm(ミクロン)である、請求項1に記載の内部人工器官。
- 前記表面は、ステント本体の表面である、請求項1に記載の内部人工器官。
- 前記第2多孔質層は、金属から形成されている、請求項1に記載の内部人工器官。
- 前記第1多孔質層および前記第2多孔質層は、ポリマーを含まない薬物送達システムを形成する、請求項1に記載の内部人工器官。
- 前記第2セラミックは、酸化イリジウムである、請求項1に記載の内部人工器官。
- 前記第2セラミックは、滑らかな球状のモルフォロジーを有する、請求項7に記載の内部人工器官。
- 前記第2セラミックは前記第1セラミックとは異なる、請求項7に記載の内部人工器官。
- 内部人工器官を形成する方法であって、
前記内部人工器官上に第1多孔質層を形成することと、
前記第1多孔質層に薬剤を導入することと、
前記薬剤を含有した第1多孔質層の上に、セラミックまたは金属の第2多孔質層を形成することと、を含み、
前記第2多孔質層は前記第1多孔質層よりも低い空隙率を有するとともに前記第2多孔質層の細孔径は、前記第1多孔質層の細孔径よりも小さい、方法。 - 前記第1多孔質層をゾル−ゲル法又はナノクラスター堆積過程によって形成することを含む、請求項10に記載の方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US11/934,353 US20090118821A1 (en) | 2007-11-02 | 2007-11-02 | Endoprosthesis with porous reservoir and non-polymer diffusion layer |
PCT/US2008/081986 WO2009059129A2 (en) | 2007-11-02 | 2008-10-31 | Endoprosthesis with porous reservoir and non-polymer diffusion layer |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2011502579A JP2011502579A (ja) | 2011-01-27 |
JP2011502579A5 true JP2011502579A5 (ja) | 2012-03-08 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010532278A Pending JP2011502579A (ja) | 2007-11-02 | 2008-10-31 | 多孔質貯蔵部および非ポリマー拡散層を備えた内部人工器官 |
Country Status (4)
Country | Link |
---|---|
US (1) | US20090118821A1 (ja) |
EP (1) | EP2214741A2 (ja) |
JP (1) | JP2011502579A (ja) |
WO (1) | WO2009059129A2 (ja) |
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-
2007
- 2007-11-02 US US11/934,353 patent/US20090118821A1/en not_active Abandoned
-
2008
- 2008-10-31 JP JP2010532278A patent/JP2011502579A/ja active Pending
- 2008-10-31 EP EP08843389A patent/EP2214741A2/en not_active Withdrawn
- 2008-10-31 WO PCT/US2008/081986 patent/WO2009059129A2/en active Application Filing
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