JP2010503482A - 内部人工器官 - Google Patents

内部人工器官 Download PDF

Info

Publication number
JP2010503482A
JP2010503482A JP2009528478A JP2009528478A JP2010503482A JP 2010503482 A JP2010503482 A JP 2010503482A JP 2009528478 A JP2009528478 A JP 2009528478A JP 2009528478 A JP2009528478 A JP 2009528478A JP 2010503482 A JP2010503482 A JP 2010503482A
Authority
JP
Japan
Prior art keywords
biodegradable
region
implantable endoprosthesis
endoprosthesis
stent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2009528478A
Other languages
English (en)
Inventor
エス． スティンソン、ジョナサン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Scientific Limited
Original Assignee
Boston Scientific Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Scientific Limited filed Critical Boston Scientific Limited
Publication of JP2010503482A publication Critical patent/JP2010503482A/ja
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A61L31/022—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155—Adjacent bands being connected to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0001—Means for transferring electromagnetic energy to implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/003—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0054—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in corrosion resistance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

生体内分解性である、または生体内分解性である部分を含む、ステント等の内部人工器官を開示する。

Description

本発明は内部人工器官ならびに内部人工器官を作製および送達する方法に関する。
身体は、動脈、その他の血管およびその他の体内の管腔等の種々の通路を含む。これらの通路は、時に、閉塞または弱化する。例えば、通路は、腫瘍により閉塞する場合、プラークにより制限される場合、または動脈瘤により弱化する場合がある。こうしたことが生じた場合、通路を、医療用の内部人工器官を用いて再開または補強することができる。内部人工器官は、典型的には、体内の管腔中に留置される管状の部材である。内部人工器官の例として、ステント、被覆型ステントおよびステント内挿型人工血管（ｓｔｅｎｔ−ｇｒａｆｔ）が挙げられる。
内部人工器官が所望の部位に輸送される間は内部人工器官を圧縮または縮小された形態で支持するカテーテルによって、内部人工器官を身体の内部に送達することができる。内部人工器官が当該の部位に到達したら、内部人工器官を、例えば、内部人工器官が管腔の壁に接触することができるように拡大する。
拡大の機構は、内部人工器官を半径方向に拡大させることを含むことができる。例えば、拡大の機構は、バルーンを担持するカテーテルを含むことができ、このカテーテルが、バルーンにより拡大可能な内部人工器官を運ぶ。バルーンを膨張させて、変形させ、拡大した内部人工器官をあらかじめ決定した位置で、管腔の壁と接触させて固定することができる。次いで、バルーンを収縮させて、カテーテルを管腔から引き抜くことができる。
米国仮特許出願第６０／８４５，３４１号 米国特許第６，９９１，７０９号 米国特許出願第１１／３５５，３９２号 米国特許出願第１１／３５５，３６８号 米国特許第６，１２０，６６０号 米国特許第６，２８７，３３２号 米国特許出願公開第２００２／０００４０６０号 米国特許出願公開第２００３／０２２１３０７号 米国特許第３，６８７，１３５号 米国特許第６，９０８，５０６号 米国特許第６，９５３，５９４号 米国特許出願公開第２００５／０２５１２４９号 米国特許第６，７３０，６９９号 米国特許第６，９６４，８１７号 米国特許第６，１１７，５９２号 米国特許第５，９７６，４５４号 米国特許第５，１９５，９６９号 米国特許第５，２７０，０８６号 米国特許第６，７２６，７１２号
フェランド（Ｆｅｒｒａｎｄｏ），Ｊ．Ｍａｔｅｒ．Ｅｎｇ．，１１，２９９（１９８９） ワングら（Ｗａｎｇ ｅｔ ａｌ．），Ｔｈｉｎ Ｓｏｌｉｄ Ｆｉｌｍｓ，４７１，８６−９０（２００５） ストローマルら（Ｓｔｒａｕｍａｌ ｅｔ ａｌ．），Ｔｈｉｎ Ｓｏｌｉｄ Ｆｉｌｍｓ，３８３，２２４−２２６（２００１） グレイら（Ｇｒａｙ ｅｔ ａｌ．），Ｊｏｕｒｎａｌ ｏｆ Ａｌｌｏｙｓ ａｎｄ Ｃｏｍｐｏｕｎｄｓ，３３６，８８−１１３（２００２） ブラクナーおよびクツェンコ（Ｂｒｕｋｎｅｒ ａｎｄ Ｋｕｔｓｅｎｋｏ），Ａｃｔａ Ｍａｔｅｒｉａｌｉａ，５２，４３２９−４３３５（２００４） パーク（Ｐａｒｋ），Ｓｃｉｅｎｃｅ ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ ｏｆ Ａｄｖａｎｃｅｄ Ｍａｔｅｒｉａｌｓ，２，７３−７８（２００１）
本発明の目的は改良された内部人工器官を提供することにある。
本開示は、一般に、被浸食性もしくは生体内分解性である内部人工器官、または被浸食性もしくは生体内分解性である部分を含む内部人工器官に関する。
１態様では、本開示は、第１の生体内分解性の材料を含む生体内分解性の本体を含む埋込み型の内部人工器官を特徴とする。生体内分解性の本体は、第１の生体内分解性の材料とは異なる第２の生体内分解性の材料を含む、複数の別個の相隔たる生体内分解性の領域を担持する。
実施形態では、それぞれの別個の相隔たる領域が、生体内分解性の本体の外側表面から延出する。そのような実施形態では、そこから領域が延出する生体内分解性の本体の外側表面に沿って測定した場合、すぐに隣接している領域間の長手方向の間隔は、例えば、約１．０μｍと約３５μｍとの間であってよく、かつ／またすぐに隣接している領域間の横方向の間隔は、例えば、約１．０μｍと約３５μｍとの間であってよい。また、そのような実施形態では、生体内分解性の本体の厚さは、例えば、約０．５ｍｍから約５．０ｍｍまでであってよく；それぞれの領域の厚さは、例えば、約０．０１μｍから約５μｍまでであってよく；かつ／またはそれぞれの領域の最も外側の上端の表面は、例えば、約２５μｍ２以下の面積を有してよい。
実施形態では、それぞれの別個の相隔たる領域が、生体内分解性の本体の最も外側の表面を越えて内側に向かって延出する。そのような実施形態では、生体内分解性の本体の外側表面に沿って測定した場合、すぐに隣接している領域間の長手方向の間隔は、例えば、約１．０μｍと約３５μｍとの間であってよく、かつ／またすぐに隣接している領域間の横方向の間隔は、例えば、約１．０μｍと約３５μｍとの間であってよい。また、そのような実施形態では、生体内分解性の本体の厚さは、例えば、約０．５ｍｍから約５．０ｍｍまでであってよく；それぞれの領域の厚さは、例えば、約０．０１μｍから約５μｍまでであってよく；かつ／またはそれぞれの領域の最も外側の上端の表面は、約２５μｍ２以下の面積を有してよい。
実施形態では、内部人工器官は、内部人工器官の周りの被覆をさらに含む。所望により、被覆は、例えば、治療剤、例として、再狭窄を阻害する治療剤を、その上および／またはその中に含むことができる。
生体内分解性の本体は、例えば、管の形態であることができる。
生体内分解性の本体は、例えば、生体内分解性の金属材料、例として、鉄、マグネシウ
ム、亜鉛、アルミニウム、カルシウムまたはそれらの合金を含むことができる。
それぞれの領域は、例えば、生体内分解性の金属材料を含むことができる。
実施形態では、生体内分解性の本体およびそれぞれの領域は、生体内分解性の金属を含む。金属が異なる場合、生体内分解性の本体およびそれぞれの領域が、一緒になってガルバニック対（ｇａｌｖａｎｉｃ ｃｏｕｐｌｅ）を画定することができる。そのような場合、ガルバニック対のための標準的な電池電位は、例えば、少なくとも＋１．０Ｖであることができる。
埋込み型の内部人工器官は、例えば、ステント、ステント内挿型人工血管またはフィルターであってよい。
所望により、生体内分解性の本体および／または領域のうちの１つもしくは複数を、例えば、電池に電気的に接続することができる。そのような実施形態は、例えば、内部人工器官の全体的な生体内分解速度を増加させることができる。そのような実施形態では、例えば、約１μＡから約２５０μＡまでの電流を、生体内分解性の本体および／または領域のうちの１つもしくは複数ならびに電池を含む回路を通して流すことができる。
別の態様では、本開示は、生体内分解性の本体を含む埋込み型の内部人工器官を特徴とする。約２５μｍ以下の最大寸法を有する断片が、埋込み型の内部人工器官のリンゲル液中での浸食の間に生じる。
例えば、生体内分解性の本体は、第１の生体内分解性の材料を含むことができ、第１の生体内分解性の材料とは異なる第２の生体内分解性の材料を含む、複数の別個の相隔たる生体内分解性の領域を担持することができる。
好ましくは、最大寸法は、約１０μｍ以下、約５μｍ以下または約１μｍ以下である。
別の態様では、本開示は、生体内分解性の本体および生体内分解性の本体の周りの被覆を含む埋込み型の内部人工器官を特徴とする。被覆は、生体内分解性の本体の断片が生体内分解の間に内部人工器官から分離するのを実質的に阻止する。
実施形態では、生体内分解性の本体は、金属材料を含み、かつ／または生体内分解性の本体は、第１の生体内分解性の材料を含み、かつ生体内分解性の本体は、第１の生体内分解性の材料とは異なる第２の生体内分解性の材料を含む、複数の別個の相隔たる生体内分解性の領域を担持する。所望により、それぞれの別個の相隔たる領域が、生体内分解性の本体の外側表面から延出することができる。
実施形態では、被覆は、相隔たる領域間に配置される。
別の態様では、本開示は、埋込み型の内部人工器官を作製する方法を特徴とする。この方法は、第１の生体内分解性の材料を含む生体内分解性の本体を提供する工程と；第１の生体内分解性の材料とは異なる第２の生体内分解性の材料を含む、複数の別個の相隔たる生体内分解性の領域を形成する工程とを含む。領域を、生体内分解性の本体が生体内分解性の領域を担持するように形成する。いくつかの実施形態では、被覆を、生体内分解性の本体上に形成する。
態様および／または実施形態は、以下の利点のうちの１つまたは複数を有する場合がある。内部人工器官を、対象、例えば、ヒト対象中への埋込み後に、あらかじめ決定した様式でかつ／またはあらかじめ決定した時点で浸食するように構成することができる。例えば、浸食のあらかじめ決定した様式は、内部人工器官の内部から、内部人工器官の外部に向けてであっても、または内部人工器官の第１の末端から内部人工器官の第２の末端に向けてであってもよい。内部人工器官の多くは、生体物質と接触することが望まれるまで、
生体物質との接触から保護される部分を有する。内部人工器官は、未制御の断片化の可能性の低下を示すことができる。断片化の様式および断片の大きさを制御することができる。内部人工器官は、埋込み後に身体から取り出す必要がない場合がある。そのような内部人工器官を埋め込まれた管腔は、再狭窄の低下を示すことができる。内部人工器官は、低い血栓形成性を有することができる。内部人工器官のいくつかは、治療剤を送達するように構成することができる。内部人工器官のいくつかは、細胞の増殖を支持する表面を有する（内皮化）。
被浸食性または生体内分解性の内部人工器官、例えば、ステントは、患者、例えば、ヒトの患者中に導入した後に、相当な質量もしくは密度の減少または化学的変質を示す装置またはその一部を指す。質量の減少は、例えば、装置を形成する材料の溶解および／または装置の断片化によって生じることができる。化学的変質は、装置またはその一部を作製する材料の酸化／還元反応、加水分解反応、置換反応、電気化学的反応および／もしくは付加反応、またはその他の化学反応を含むことができる。浸食は、装置を埋め込んだ生体環境、例えば、身体自体もしくは体液との装置の化学的および／もしくは生物学的な相互作用の結果である場合があり、かつ／または浸食を、化学反応物質等の誘発性の影響もしくはエネルギーを装置に適用して反応速度を増加させることによって引き起す場合がある。例えば、装置またはその一部を、活性金属、例えば、ＭｇもしくはＣａまたはそれらの合金から形成してよく、これらの金属は、水との反応によって浸食して、対応する金属酸化物および水素ガスを発生させる（酸化還元反応）。例えば、装置またはその一部を、水による加水分解によって浸食させることができる被浸食性もしくは生体内分解性のポリマーまたは合金または被浸食性もしくは生体内分解性のポリマーのブレンドから形成することができる。浸食が、望ましい程度で、治療の利益を提供することができる時間枠内に生じる。例えば、実施形態では、装置の機能、例として、管腔の壁の支持または薬物送達が最早必要でないか、望まれない時点に達すると、装置は、相当な質量の減少を示す。特定の実施形態では、装置は、埋め込んでから１日以上、例えば、約６０日以上、約１８０日以上、約６００日以上または約１０００日以下の期間の後に、約１０パーセント以上、例えば、約５０パーセント以上の質量の減少を示す。実施形態では、装置は、浸食工程による断片化を示す。例えば、装置のいくつかの領域が、その他の領域よりも迅速に浸食するので、断片化が生じる。より速く浸食する領域は、内部人工器官の本体およびより緩慢に浸食する領域からの断片を通してより急速に浸食することによって弱化する。より速く浸食する領域およびより緩慢に浸食する領域は、無作為であっても、またはあらかじめ画定してもよい。例えば、より速く浸食する領域を、領域を処理して領域の化学反応性を増強することによってあらかじめ画定することができる。別法として、領域を処理して、例えば、被覆を使用することによって、浸食速度を低下させることができる。実施形態では、装置の部分のみが、被浸食性を示す。例えば、外側の層または被覆が被浸食性であることができ、一方、内側の層または本体は非被浸食性である。実施形態では、内部人工器官は、非被浸食性の材料の内部に分散した被浸食性の材料から形成され、それによって、浸食後には、装置は、被浸食性の材料の浸食によって空隙率を増加させている。
浸食速度を、０．２ｍ／秒の速度で流れるリンゲル液の流れの中に浮遊させた試験装置を用いて測定することができる。試験の間、試験装置の全ての表面を、流れに暴露させてよい。本開示の目的では、リンゲル液は、最近沸騰させた蒸留水の、１リットルあたり８．６グラムの塩化ナトリウム、０．３グラムの塩化カリウムおよび０．３３グラムの塩化カルシウムを含有する溶液である。
本願明細書で使用する場合、「金属材料」は、純粋な金属、金属合金または金属複合材料を意味する。
本願明細書で言及する全ての刊行物、特許出願、特許およびその他の参照文献は、それらの全体を本願明細書に援用する。
その他の態様、特徴および利点は、説明および図面、ならびに特許請求の範囲から明らかであろう。
生体内分解性の本体の外側表面から延出する複数の別個の相隔たる生体内分解性の領域を担持する生体内分解性の本体を含むステントの送達を示す長手方向の横断面図。分解した状態のステントを示す図。 生体内分解性の本体の外側表面から延出する複数の別個の相隔たる生体内分解性の領域を担持する生体内分解性の本体を含むステントの送達を示す長手方向の横断面図。ステントの拡大を示す図。 生体内分解性の本体の外側表面から延出する複数の別個の相隔たる生体内分解性の領域を担持する生体内分解性の本体を含むステントの送達を示す長手方向の横断面図。ステントの配置を示す図。 図１Ａの未拡大のステントの斜視図。 ２Ａ−２Ａに沿って見た図２のステントの横断面図。 ２Ｂ−２Ｂに沿って見た図２のステントの長手方向の横断面図。 図２のステントの１実施形態の生体内分解を示す横断面図。 図２のステントの１実施形態の生体内分解を示す横断面図。 図２のステントの１実施形態の生体内分解を示す斜視図。 図２のステントの１実施形態の生体内分解を示す斜視図。 図２のステントの１実施形態の生体内分解を示す平面図。 生体内分解性の本体の最も外側の表面を越えて内側に向かって延出する複数の別個の相隔たる生体内分解性の領域を担持する生体内分解性の本体を含むステントの代替の実施形態の斜視図。 ４Ａ−４Ａに沿って見た図４のステントの横断面図。 別個の相隔たる領域間の間隔を充填する被覆を有する図２のステントの横断面図。 図５のステントの１実施形態の生体内分解を示す、一連の横断面図。 図５のステントの１実施形態の生体内分解を示す、一連の横断面図。 図５のステントの１実施形態の生体内分解を示す、一連の横断面図。 ステントの１つの製造方法を示す一連の斜視図。
図１Ａ〜１Ｃおよび２〜２Ｂを参照すると、ステント１０は、第１の生体内分解性の材料を含む管状の生体内分解性の本体１１を含む。生体内分解性の本体１１は、横断面が環状であり、本体１１の外側表面１５から外側に向かって延出する、複数の別個の相隔たる生体内分解性の領域１３を担持する。示すように、それぞれの領域１３は、上から見ると長方形である突出部を画定するが、領域は、その大きさのために裸眼では見ることができない場合がある。いくつかの実施形態では、領域を、光学顕微鏡または走査型電子顕微鏡を用いて、視覚化する必要がある場合がある。領域１３は、第１の生体内分解性の材料とは異なる第２の生体内分解性の材料を含む。ステント１０を、カテーテル１４の遠位末端の付近に担持されるバルーン１２の上に置き、管腔１６を通して（図１Ａ）、バルーン１２およびステント１０を運ぶ部分が閉塞領域１８に到達するまで導く。次いで、ステント１０を、バルーンを膨張させることによって半径方向に拡大させて、血管壁に対して押し付け、その結果、閉塞が押し付けられて、閉塞を囲む血管壁が、半径方向に拡大する（図１Ｂ）。次いで、圧力をバルーン１２から解放し、カテーテル１４を、血管から引き抜き（図１Ｃ）、拡大したステント１０’を管腔１６中に残留させる。
領域１３を形成する材料、領域の厚さＴ１、生体内分解性の本体１１を形成する材料、
本体の厚さＴ、領域間の横方向の間隔ＳＴ、および領域間の長手方向の間隔Ｓｌを選んで、所望の機械的な特性を、所望の生体内分解速度、生体内分解の様式および断片の大きさ、例えば、約２５μ以下と共に提供する。実施形態では、断片は、大きな白血球細胞のおよその大きさ以下である、例えば、約１５μｍ以下の最大寸法を有する。好ましい実施形態では、最大寸法は、約１０μｍ以下、約５μｍ以下または約１μｍ以下である。
ここで図３Ａ〜３Ｅも参照すると、これらの図は、本体１１を、例えば、鉄で形成し、領域１３を、例えば、マグネシウムで形成した図２に示したステントの１実施形態の生体内分解を示す。生体内分解の初期の段階（図３Ａ）では、マグネシウムで形成した領域は、比較的急速に浸食し、それらの浸食速度は、本体の鉄とマグネシウムとの間のガルバニック反応によって増強される。生体内分解のこれらの初期の段階では、割れ目３０が、領域の近位の本体中に出現し、領域の真下の部分３２が、ガルバニック反応によって弱化する。割れ目３０は、割れ目中の反応性のイオンの濃度がより高く、より速い反応速度をもたらすために、鉄の本体の浸食速度を増強すると考えられている。生体内分解が続く（図３Ｂ）と、深いくぼみ３６が、鉄の本体中に形成される。くぼみの中の浸食が増強され、その結果、くぼみが、鉄の本体中に画定された開口部４０となる（図３Ｃ）。開口部の大きさが広がり（図３Ｄ）、本体が、最大寸法Ｍ、例えば、１５μｍ、１０μｍ、５μｍ以下または１μｍ以下を有する断片４５（図３Ｅ）に崩壊するのに至る（図３Ｄ）。
実施形態では、生体内分解性の本体１１の外側表面１５に沿って測定した場合、すぐに隣接している領域間の横方向のＳＴ間隔は、約１．０μｍと約３５μｍとの間、例えば、約１．０μｍと約２０μｍとの間または約２．０μｍと約１５μｍとの間であり；すぐに隣接している領域間の長手方向の間隔Ｓｌは、約１．０μｍと約３５μｍとの間、例えば、約１．０μｍと約２０μｍとの間または約２．０μｍと約１５μｍとの間である。実施形態では、それぞれの領域の最も外側の上端の表面１７（図２）は、約２５μｍ２以下、例えば、約１５μｍ２以下または約５μｍ２以下の面積を有する。実施形態では、領域１３を、生体内分解性の金属材料またはセラミック材料で形成し、領域の厚さＴ１は、例えば、約０．０１μｍと約１０μｍとの間、例えば、約０．０５μｍと約７．５μｍとの間または約０．１μｍと約５μｍとの間である。実施形態では、生体内分解性の本体１１を、生体内分解性の金属材料またはセラミック材料から形成し、横方向の厚さＴは、例えば、約０．１ｍｍと約２．５ｍｍとの間、例えば、約０．２５ｍｍと約２．０ｍｍとの間または約０．３ｍｍと約１．５ｍｍとの間である。
実施形態では、領域１３および本体１１を、実質的に異なる標準的な還元電位を有する実質的に異なる金属で形成して、異なる金属間におけるガルバニック反応を誘発する。例えば、ガルバニック対のための標準的な電池電位は、約２．００Ｖ超、例えば、１．７５Ｖ、１．５０Ｖ、１．００Ｖ、０．５Ｖ超であっても、または約０．２５Ｖ超であってもよい。そのような場合、金属のうちの一方が、他方の金属の浸食を増強し；一方、同時に、他方の金属が、他方の金属による浸食から保護される。例えば、特定の実施形態では、本体を鉄で形成し、それぞれの領域をマグネシウムで形成する。この場合、マグネシウムの浸食は鉄によって増強され；一方、同時に、鉄の浸食は抑制される。そのようなステントの構成は、全ステントの全体的な分解時間を短縮させ、かつ／またはステントに沿って分解が始まる場所の制御を増強することができる。マグネシウムおよびマグネシウム合金の浸食は、（非特許文献１）で概説されている。所望により、生体内分解性の本体および／または領域のうちの１つもしくは複数を、電池に電気的に接続して、例えば、ステントまたはステントの一部の浸食速度を増強することができる。例えば、約１μＡから約２５０μＡまでの電流、例えば、約５μＡから約１７５μＡまでまたは約１０μＡから約１００μＡまでの電流を、生体内分解性の本体および／または領域のうちの１つもしくは複数ならびに電池を含む回路を通して流すことができる。
実施形態では、本体１１を、領域１３よりも遅い生体内分解速度を有する材料で形成する。例えば、本体の材料は、例えば、領域の材料の浸食速度の約５０パーセント未満、約３５パーセント未満、約２０パーセント未満、約１５パーセント未満、約１０パーセント未満、約５パーセント未満、約２．５パーセント未満、または領域の材料の浸食速度の約１パーセント未満さえである速度で浸食することができる。例えば、特定の実施形態では、本体１１を鉄で形成し、領域１３を、例えば、生体内分解性の本体１１の外側表面１５上にスパッタすることによって堆積させたマグネシウムで形成する。ステントを２５℃の０．２ｍ／秒の速度で流れるリンゲル液の流れの中に浮遊させて、浸食の間に形成された断片を測定することによって、ステントを試験することができる。断片の数および大きさを、レーザー光散乱を使用して決定することができる。本開示の目的では、リンゲル液は、最近沸騰させた蒸留水の、１リットルあたり８．６グラムの塩化ナトリウム、０．３グラムの塩化カリウムおよび０．３３グラムの塩化カルシウムを含有する溶液である。
領域１３を、ディップ塗布、吹き付け塗装、パルスレーザー堆積、物理気相成長（例えば、スパッタリング）、化学気相成長、真空アーク蒸着、電気化学めっき、粉末塗装、塗装、電解被覆、ゾル−ゲル被覆およびポリマーめっき（例えば、プラズマ重合）をはじめとする、多様な技術によって作製することができる。パルスレーザー堆積は、（非特許文献２）に記載されており；真空アーク蒸着は、（非特許文献３）に記載されており；スパッタリングは、ゴパルラジャら（Ｇｏｐａｌｒａｊａ ｅｔ ａｌ．）によって（特許文献２）に記載されており；マグネシウム上への被覆は、（非特許文献４）に概説されている。
ここで図４および４Ａを参照すると、ある実施形態では、ステント８０は、第１の生体内分解性の材料を含む管状の生体内分解性の本体８２を含む。生体内分解性の本体８２は、横断面が環状であり、生体内分解性の本体８２の外側表面８６を越えて内側に向かって延出する、複数の別個の相隔たる生体内分解性の領域８４を担持する。示すように、それぞれの領域８４は、上から見ると長方形であり、その端部上に生体内分解性の本体８２の外側表面８６と滑らかな移行部を形成する。領域は、その大きさのためまたは本体の材料と領域の材料との間のわずかな視覚的な差のために裸眼では見ることができない場合がある。場合によっては、領域を、光学顕微鏡または走査型電子顕微鏡を用いて、視覚化する必要がある場合がある。領域８４は、第１の生体内分解性の材料とは異なる第２の生体内分解性の材料を含む。ステント８０を、図２のステントに関して上記で議論したように送達することができる。
実施形態では、領域８４および本体８２を、実質的に異なる標準的な還元電位を有する実質的に異なる金属で形成して、異なる金属間におけるガルバニック反応を誘発する。例えば、本体８２を鉄で形成することができ、領域８４をマグネシウムまたはマグネシウム合金で形成することができる。上記で議論したように、生体内分解性の本体および／または領域のうちの１つもしくは複数を、電池に電気的に接続して、例えば、ステントまたはステントの一部の浸食速度を増強することができる。厚さＴ１’、生体内分解性の本体８２を形成する材料、厚さＴ’、間隔ＳＴ’および間隔Ｓｌ’は、図２のステントに関して上記で議論した値のうちのいずれかを有することができる。それぞれの領域の最も外側の上端の表面９０は、約２５μｍ２以下、例えば、約１５μｍ２以下または約５μｍ２以下の面積を有することができる。
領域を、ステントの本体中に開口部をエッチングして、開口部を第２の生体内分解性の材料で充填することによって形成することができる。領域８４を、ステントの本体を別個の領域において改変するイオン注入（例えば、プラズマ浸漬イオン注入）、レーザー処理および化学処理をはじめとする技術によって作製することができる。プラズマ浸漬イオン注入（ＰＩＩＩ）は、ウェーバーら（Ｗｅｂｅｒ ｅｔ ａｌ．）によって“Ｍｅｄｉｃ
ａｌ Ｂａｌｌｏｏｎｓ Ａｎｄ Ｍｅｔｈｏｄｓ Ｏｆ Ｍａｋｉｎｇ Ｔｈｅ Ｓａｍｅ”、２００６年２月１６日出願の（特許文献３）および“Ｂｉｏｅｒｏｄｉｂｌｅ Ｅｎｄｏｐｒｏｓｔｈｅｓｅｓ Ａｎｄ Ｍｅｔｈｏｄｓ Ｏｆ Ｍａｋｉｎｇ Ｔｈｅ
Ｓａｍｅ”、２００６年２月１６日出願の（特許文献４）に；チュー（Ｃｈｕ）によって（特許文献５）に；かつ（非特許文献５）に記載されている。
ここで図５を参照すると、１実施形態では、図２のステントは、領域１３間の間隔を充填するが、領域１３を被覆しない被覆１１０を含むことができる。示す特定の実施形態では、被覆の厚さＴＣは、領域１３の厚さＴ１を超えて延出することがないようになす。被覆１１０は、生体内分解性であっても、または非生体内分解性であってもよい。被覆１１０が、非生体内分解性の場合、これは、ポリマー性材料、金属材料（例えば、金属もしくは金属合金）またはセラミック材料であってもよいし、あるいはそれらを含んでもよい。
ここで図５Ａ〜５Ｃも参照すると、特定の実施形態では、本体１１は鉄であり、領域１３を、マグネシウムで形成し、被覆１１０は非生体内分解性であり、被覆は、生体内分解性の本体１１を形成する材料とステントが埋め込まれている管腔との間の直接的な接触を阻止し、また、ステントが生体内分解する様式に対する追加の制御も可能にする。生体内分解の初期の段階（図５Ａ）では、マグネシウムで形成した領域および領域の下の密接に接近している部分は、比較的急速に浸食し、それらの浸食速度は、本体の鉄とマグネシウムとの間のガルバニック反応によって増強される。生体内分解が続くと、深いくぼみが、被覆１１０が真下の本体の生体内分解性の材料の生体内分解を阻止するので、大きさが外部へ広がることがない開口部１２０になる（図５Ｂ）。次いで、生体内分解が、内部から外部に向けて進み、被覆１１０は、ステントが管腔の内部で断片化するのを防ぐための「糊」として作用する。
ここで図６を参照すると、ステントを、空洞の管状のステント前駆体５０を提供し、次いで、マスク５２をステント前駆体５０の周りに置くことによって作製することができる。マスク５２は、領域１３の厚さＴ１にほぼ等しい厚さを有する、ＭＹＬＡＲ（登録商標）ポリエステルのフィルムまたは熱収縮性ポリオレフィンのフィルム等の薄板材料で作製することができる。マスク５２は、領域１３に位置関係的に対応する、マスクの壁６０の中に画定された複数の開口部５８を有する。さらに、マスク５２は、ミシン目６２を含み、それによって、領域１３を形成した後に、マスク５２を取り外すことができる。開口部およびミシン目を、リソグラフィー、レーザー切断または切断によって形成することができる。領域は、上記の技術によって形成することができる。例えば、アセンブリ７０を回転させながら、材料をアセンブリ上にスパッタすることができる。スパッタする材料は、ステント前駆体に、開口部を介して接触できるが、マスクした領域中では、ステント前駆体と接触することが阻止される。領域を形成した後、ミシン目６２に沿って引き裂くことによってマスク５２を取り外して、ステントを解放する。
上記したように、浸食速度を増加させる領域を、ステント上にパターン形成することができる。実施形態では、浸食速度を低下させる領域を、ステント上にパターン形成することができる。例えば、ステントの部分を体液への暴露またはガルバニックな腐食から保護する被浸食性もしくは非被浸食性の金属、セラミックまたはポリマーの被覆を、ステント上に提供し、一方、腐食を進めるその他の部分は暴露させる。被覆は、被浸食性または非被浸食性のポリマーまたは材料であってよい。被覆は、ステントの外側上のみ、内側上のみ、または外側上および内側上の両方に提供してよい。
実施形態では、生体内分解性の本体を、生体内分解性のポリマー性材料から形成し、横方向の厚さＴは、例えば、約０．５ｍｍと約５．０ｍｍとの間、例えば、約０．５ｍｍと約３．０ｍｍとの間または約１ｍｍと約２．５ｍｍとの間であることができる。領域を生
体内分解性のポリマー性材料で形成する実施形態では、領域の厚さＴ１は、例えば、約１μｍと約１００μｍとの間、例えば、約１μｍと約５０μｍとの間または約５μｍと約３５μｍとの間であることができる。
種々の生体内分解性の材料、ポリマーおよびセラミックを、本願明細書に記載する実施形態において使用することができる。
領域１３を形成することができる生体内分解性の金属または金属合金の例として、鉄およびマグネシウムが挙げられる。鉄合金の例として、低炭素鋼（ＡＩＳＩ １０１８−１０２５）、中炭素鋼（ＡＩＳＩ １０３０−１０５５）、高炭素鋼（１０６０−１０９５）および二元Ｂｉ−Ｆｅ合金が挙げられる。合金のその他の例として、マグネシウム合金、例として、５０〜９８重量％マグネシウム、０〜４０重量％リチウム、０〜５重量％鉄ならびに５重量％未満のその他の金属もしくは希土類元素；または７９〜９７重量％マグネシウム、２〜５重量％アルミニウム、０〜１２重量％リチウムならびに１〜４重量％希土類元素（例として、セリウム、ランタン、ネオジムおよび／もしくはプラセオジム）；または８５〜９１重量％マグネシウム、６〜１２重量％リチウム、２重量％アルミニウムならびに１重量％希土類元素；または８６〜９７重量％マグネシウム、０〜８重量％リチウム、２〜４重量％アルミニウムならびに１〜２重量％希土類元素；または８．５〜９．５重量％アルミニウム、０．１５〜０．４重量％マンガン、０．４５〜０．９重量％亜鉛ならびに残りはマグネシウム；または４．５〜５．３重量％アルミニウム、０．２８〜０．５重量％マンガンならびに残りはマグネシウム；または５５〜６５重量％マグネシウム、３０〜４０重量％リチウムならびに０〜５重量％のその他の金属および／もしくは希土類元素が挙げられる。マグネシウム合金は、ＡＺ９１Ｄ、ＡＭ５０ＡおよびＡＥ４２の名で入手可能であり、これらは、マグネシウム−エレクトロンコーポレーション社（Ｍａｇｎｅｓｉｕｍ−Ｅｌｅｋｔｒｏｎ Ｃｏｒｐｏｒａｔｉｏｎ［英国］）から入手できる。その他の被浸食性の金属または金属合金が、ボルツ（Ｂｏｌｚ）によって（特許文献６）（例えば、亜鉛−チタン合金およびナトリウム−マグネシウム合金）に；ヒューブレイン（Ｈｅｕｂｌｅｉｎ）によって（特許文献７）に；キーセ（Ｋａｅｓｅ）によって（特許文献８）に；ストロガノフ（Ｓｔｒｏｇａｎｏｖ）によって（特許文献９）に；かつ（非特許文献６）に記載されている。
領域１３を形成することができる生体内分解性のセラミックの例として、ベータ−第三リン酸カルシウム（β−ＴＣＰ）、β−ＴＣＰとヒドロキシアパタイトとのブレンド、ＣａＨＰＯ４、ＣａＨＰＯ４−２Ｈ２Ｏ、ＣａＣＯ３およびＣａＭｇ（ＣＯ３）２が挙げられる。その他の生体内分解性のセラミックが、ツィーマーマン（Ｚｉｍｍｅｒｍａｎｎ）によって（特許文献１０）で、かつリー（Ｌｅｅ）によって（特許文献１１）で議論されている。
領域１３を形成することができる生体内分解性のポリマーの例として、ポリカプロラクトン（ＰＣＬ）、ポリカプロラクトン−ポリ乳酸コポリマー（例えば、ポリカプロラクトン−ポリ乳酸ランダムコポリマー）、ポリカプロラクトン−ポリグリコライドコポリマー（例えば、ポリカプロラクトン−ポリグリコライドランダムコポリマー）、ポリカプロラクトン−ポリ乳酸−ポリグリコライドコポリマー（例えば、ポリカプロラクトン−ポリ乳酸−ポリグリコライドランダムコポリマー）、ポリ乳酸、ポリカプロラクトン−ポリ（β−ヒドロキシ酪酸）コポリマー（例えば、ポリカプロラクトン−ポリ（β−ヒドロキシ酪酸）ランダムコポリマー）、ポリ（β−ヒドロキシ酪酸）、およびこれらのポリマーの混合物が挙げられる。生体内分解性のポリマーの追加の例が、サハシャンら（Ｓａｈａｔｊｉａｎ ｅｔ．ａｌ．）によって（特許文献１２）に記載されている。
被覆１１０を形成することができる非生体内分解性のポリマーの例として、ポリシクロオクテン（ＰＣＯ）、スチレン−ブタジエンゴム、ポリ酢酸ビニル、ポリビニリデンフル
オライド（ＰＶＤＦ）、ポリメチルメタクリレート（ＰＭＭＡ）、ポリウレタン、ポリエチレン、ポリ塩化ビニル（ＰＶＣ）、およびそれらのブレンドが挙げられる。非生体内分解性のポリマーの追加の例が、サハシャンら（Ｓａｈａｔｊｉａｎ ｅｔ．ａｌ．）によって（特許文献１２）に記載されている。被覆１１０を形成することができる非被浸食性の金属および金属合金の例として、ステンレス鋼、レニウム、モリブデンおよびモリブデン−レニウム合金が挙げられる。被覆１１０を形成することができる非生体内分解性のセラミックの例として、ケイ素の酸化物（例えば、二酸化ケイ素）、チタンの酸化物（例えば、二酸化チタン）、またはジルコニウムの酸化物（例えば、二酸化ジルコニウム）が挙げられる。
所望により、本願明細書に記載するステントのうちのいずれもが、治療剤を、ステントの上もしくは中および／またはステントの周りの被覆の上もしくは中に含むことができる。治療剤は、遺伝子治療剤、非遺伝子治療剤または細胞であってよい。治療剤は、単独でまたは組み合せて使用してよい。治療剤は、その性質が、例えば、非イオン性であってもよいし、またはアニオン性および／もしくはカチオン性であってもよい。好ましい治療剤は、再狭窄を阻害する治療剤である。再狭窄を阻害する１つのそのような治療剤の具体的な例は、パクリタキセルまたはその誘導体、例えば、ドセタキセルである。パクリタキセルの２’のヒドロキシル基をはずして、可溶化部分、例として、−ＣＯＣＨ２ＣＨ２ＣＯＮＨＣＨ２ＣＨ２（ＯＣＨ２）ｎＯＣＨ３（ｎは、例えば、１から約１００以上）をつなぐことによって、可溶性のパクリタキセル誘導体を作製することができる。リら（Ｌｉ ｅｔ ａｌ．）が、パクリタキセルの追加の水溶性誘導体を記載している（特許文献１３）。
Figure 2010503482
例示的な非遺伝子治療剤として、（ａ）抗血栓剤、例として、ヘパリン、ヘパリン誘導体、ウロキナーゼ、ＰＰａｃｋ（デキストロフェニルアラニン・プロリン・アルギニン・クロロメチルケトン）およびチロシン；（ｂ）抗炎症剤、例として、非ステロイド性抗炎症剤（ＮＳＡＩＤ）、具体的には、デキサメタゾン、プレドニゾロン、コルチコステロン、ブデソニド、エストロゲン、スルファサラジンおよびメサラミン；（ｃ）抗悪性腫瘍剤／抗増殖剤／有糸***阻害剤、例として、パクリタキセル、５−フルオロウラシル、シスプラチン、ビンブラスチン、ビンクリスチン、エポチロン、エンドスタチン、アンジオスタチン、アンギオペプチン、ラパマイシン（シロリムス）、ビオリムス（ｂｉｏｌｉｍｕｓ）、タクロリムス、エベロリムス、平滑筋細胞の増殖を遮断することができるモノクローナル抗体およびチミジンキナーゼ阻害剤；（ｄ）麻酔剤、例として、リドカイン、ブピバカインおよびロピバカイン；（ｅ）抗凝血剤、例として、Ｄ−Ｐｈｅ−Ｐｒｏ−Ａｒｇクロロメチルケトン、ＲＧＤペプチド含有化合物、ヘパリン、ヒルジン、抗トロンビン化
合物、血小板受容体アンタゴニスト、抗トロンビン抗体、抗血小板受容体抗体、アスピリン、プロスタグランジン阻害剤、血小板阻害剤およびダニ抗血小板ペプチド；（ｆ）血管細胞成長促進物質、例として、増殖因子、転写活性化因子および翻訳促進物質；（ｇ）血管細胞成長阻害剤、例として、増殖因子阻害剤、増殖因子受容体アンタゴニスト、転写抑制因子、翻訳抑制因子、複製阻害剤、抑制抗体、増殖因子に対して作られた抗体、増殖因子と細胞毒とからなる二機能性分子、抗体と細胞毒とからなる二機能性分子；（ｈ）タンパク質キナーゼ阻害剤およびチロシンキナーゼ阻害剤（例えば、チロホスチン、ゲニステイン、キノキサリン）；（ｉ）プロスタサイクリン類似体；（ｊ）コレステロール低下剤；（ｋ）アンジオポエチン；（ｌ）抗菌剤、例として、トリクロサン、セファロスポリン、アミノグリコシドおよびニトロフラントイン；（ｍ）細胞障害剤、細胞***阻害剤および細胞増殖影響因子；（ｎ）血管拡張剤；（ｏ）内因性の血管作動性の機構を妨げる薬剤；（ｐ）白血球動員阻害剤、例として、モノクローナル抗体；（ｑ）サイトカイン、（ｒ）ホルモン；ならびに（ｓ）鎮痙剤、例として、アリベンドール（ａｌｉｂｅｎｄｏｌ）、アンブセタミド（ａｍｂｕｃｅｔａｍｉｄｅ）、アミノプロマジン（ａｍｉｎｏｐｒｏｍａｚｉｎｅ）、アポアトロピン（ａｐｏａｔｒｏｐｉｎｅ）、メチル硫酸ベボニウム、ビエタミベリン（ｂｉｅｔａｍｉｖｅｒｉｎｅ）、ブタベリン（ｂｕｔａｖｅｒｉｎｅ）、臭化ブトロピウム、臭化ｎ−ブチルスコポラミン、カロベリン、臭化シメトロピウム、シンナメドリン（ｃｉｎｎａｍｅｄｒｉｎｅ）、クレボプリド、臭化水素酸コニイン（ｃｏｎｉｉｎｅ ｈｙｄｒｏｂｒｏｍｉｄｅ）、塩酸コニイン（ｃｏｎｉｉｎｅ ｈｙｄｒｏｃｈｌｏｒｉｄｅ）、ヨウ化シクロニウム、ジフェメリン、ジイソプロミン、酪酸ジオキサフェチル（ｄｉｏｘａｐｈｅｔｙｌ ｂｕｔｙｒａｔｅ）、臭化ジポニウム、ドロフェニン（ｄｒｏｆｅｎｉｎｅ）、臭化エメプロニウム、エタベリン（ｅｔｈａｖｅｒｉｎｅ）、フェクレミン（ｆｅｃｌｅｍｉｎｅ）、フェナラミド（ｆｅｎａｌａｍｉｄｅ）、フェノベリン、フェンピプラン、臭化フェンピベリニウム、臭化フェントニウム、フラボキサート、フロプロピオン、グルコン酸、グアイアクタミン（ｇｕａｉａｃｔａｍｉｎｅ）、ヒドラミトラジン（ｈｙｄｒａｍｉｔｒａｚｉｎｅ）、ヒメクロモン、レイオピロール（ｌｅｉｏｐｙｒｒｏｌｅ）、メベベリン、モキサベリン（ｍｏｘａｖｅｒｉｎｅ）、ナフィベリン（ｎａｆｉｖｅｒｉｎｅ）、オクタミルアミン（ｏｃｔａｍｙｌａｍｉｎｅ）、オクタベリン（ｏｃｔａｖｅｒｉｎｅ）、塩化オキシブチニン、ペンタピペリド（ｐｅｎｔａｐｉｐｅｒｉｄｅ）、塩酸フェナマシド（ｐｈｅｎａｍａｃｉｄｅ ｈｙｄｒｏｃｈｌｏｒｉｄｅ）、フロログルシノール、臭化ピナベリウム、ピペリレート（ｐｉｐｅｒｉｌａｔｅ）、塩酸ピポキソラン（ｐｉｐｏｘｏｌａｎ ｈｙｄｒｏｃｈｌｏｒｉｄｅ）、プラミベリン（ｐｒａｍｉｖｅｒｉｎ）、臭化プリフィニウム、プロペリジン（ｐｒｏｐｅｒｉｄｉｎｅ）、プロピバン（ｐｒｏｐｉｖａｎｅ）、プロピロマジン（ｐｒｏｐｙｒｏｍａｚｉｎｅ）、プロザピン（ｐｒｏｚａｐｉｎｅ）、ラセフェミン（ｒａｃｅｆｅｍｉｎｅ）、ロシベリン、スパスモリトール（ｓｐａｓｍｏｌｙｔｏｌ）、ヨウ化スチロニウム（ｓｔｉｌｏｎｉｕｍ ｉｏｄｉｄｅ）、スルトロポニウム（ｓｕｌｔｒｏｐｏｎｉｕｍ）、ヨウ化チエモニウム、臭化チキジウム、チロプラミド、トレピブトン（ｔｒｅｐｉｂｕｔｏｎｅ）、トリクロミル（ｔｒｉｃｒｏｍｙｌ）、トリホリウム（ｔｒｉｆｏｌｉｕｍ）、トリメブチン、トロペンジル（ｔｒｏｐｅｎｚｉｌｅ）、塩化トロスピウム、臭化キセニトロピウム（ｘｅｎｙｔｒｏｐｉｕｍ ｂｒｏｍｉｄｅ）、ケトロラク、およびそれらの薬学的に許容される塩が挙げられる。
例示的な遺伝子治療剤として、アンチセンスＤＮＡおよびＲＮＡ、さらに（ａ）アンチセンスＲＮＡ、（ｂ）欠陥のあるまたは欠損した内因性の分子を置換するためのｔＲＮＡまたはｒＲＮＡ、（ｃ）増殖因子、例として、酸性および塩基性の線維芽細胞増殖因子、血管内皮増殖因子、上皮増殖因子、形質転換増殖因子αおよびβ、血小板由来内皮増殖因子、血小板由来増殖因子、腫瘍壊死因子α、肝細胞増殖因子ならびにインスリン様増殖因子をはじめとする血管新生因子、（ｄ）ＣＤ阻害剤をはじめとする細胞周期阻害剤、さらに（ｅ）チミジンキナーゼ（「ＴＫ」）、さらに細胞増殖を妨げるのに有用なその他の薬
剤をコードするＤＮＡが挙げられる。また、骨形態形成タンパク質（「ＢＭＰ」）ファミリー、例として、ＢＭＰ−２、ＢＭＰ−３、ＢＭＰ−４、ＢＭＰ−５、ＢＭＰ−６（Ｖｇｒ−ｌ）、ＢＭＰ−７（ＯＰ−１）、ＢＭＰ−８、ＢＭＰ−９、ＢＭＰ−１０、ＢＭＰ−１１、ＢＭＰ−１２、ＢＭＰ−１３、ＢＭＰ−１４、ＢＭＰ−１５およびＢＭＰ−１６をコードするＤＮＡも対象となる。現在のところ、好ましいＢＭＰは、ＢＭＰ−２、ＢＭＰ−３、ＢＭＰ−４、ＢＭＰ−５、ＢＭＰ−６およびＢＭＰ−７のうちのいずれかである。これらの二量体タンパク質を、ホモダイマー、ヘテロダイマーまたはそれらの組合せとして、単独でまたはその他の分子と一緒にして提供してよい。別法としてまたはそれに加えて、ＢＭＰの上流または下流の効果を誘発することができる分子を提供してもよい。そのような分子として、「ヘッジホッグ」タンパク質のうちのいずれか、またはそれらをコードするＤＮＡが含まれる。
遺伝子治療剤を送達するためのベクターは、アデノウイルス、腸内アデノウイルス、アデノ随伴ウイルス、レトロウイルス、アルファウイルス（セムリキ森林、シンドビス等）、レンチウイルス、単純ヘルペスウイルス、自己複製能をもつウイルス（例えば、ＯＮＹＸ−０１５）およびハイブリッドベクター等のウイルスベクター；ならびに人工染色体およびミニ染色体、プラスミドＤＮＡベクター（例えば、ｐＣＯＲ）、カチオン性ポリマー（例えば、ポリエチレンイミン、ポリエチレンイミン（ＰＥＩ））、グラフトコポリマー（例えば、ポリエーテル−ＰＥＩおよびポリエチレンオキシド−ＰＥＩ）、中性ポリマーであるＰＶＰ、ＳＰ１０１７（スプラテック社（ＳＵＰＲＡＴＥＫ））、カチオン性脂質等の脂質、リポソーム、リポプレックス、ナノ粒子または微小粒子等の非ウイルスベクターを含み、これらは、タンパク質透過ドメイン（ＰＴＤ）等の標的配列を有する場合とそうでない場合とがある。
使用する細胞は、全骨髄、骨髄由来の単核細胞、前駆細胞（例えば、血管内皮前駆細胞）、幹細胞（例えば、間葉系、造血、神経）、多能性幹細胞、線維芽細胞、筋芽細胞、サテライト細胞、周皮細胞、心筋細胞、骨格筋細胞もしくはマクロファージをはじめとする、ヒト起源の細胞（自己または同種）、または動物、細菌もしくは真菌を起源とする細胞（異種）を含み、これらを、所望により、対象とするタンパク質を送達するために遺伝子操作することができる。
ステントの本体、領域または被覆を形成するために使用する金属材料、セラミック材料またはポリマー性材料のうちのいずれであっても、多孔性に作製することができる。例えば、多孔性の金属材料を、例えば、約０．０１ミクロンと約２０ミクロンとの間の直径を有する金属粒子を焼結して、流体が流れることができる相互に接続している小さな（例えば、約０．０５ミクロンから約０．５ミクロンまでの）空隙および大きな（例えば、約１ミクロンから約１０ミクロンまでの）空隙を有する多孔性の材料を形成することによって作製することができる。多孔性の材料中の空隙は、例えば、多孔性の材料内にインタカレートしている治療剤のための保管場所として、またはその部分もしくは成分に関する浸食速度を増加させるために使用することができる。
そのような多孔性の材料は、水銀ポロシメータを使用して測定した場合、約８０から約９９パーセント、例えば、約８０から約９５パーセントまたは約８５から約９２パーセントの全空隙率、およびＢＥＴ（ブルナウアー、エメットおよびテラー）を使用して測定した場合、約２００ｃｍ２／ｃｍ３から約１０，０００ｃｍ２／ｃｍ３まで、例えば、約２５０ｃｍ２／ｃｍ３から約５，０００ｃｍ２／ｃｍ３までまたは約４００ｃｍ２／ｃｍ３から約１，０００ｃｍ２／ｃｍ３までの比表面積を有することができる。生体内分解性の材料を利用する場合、材料の多孔性の性質が、材料の表面積を増加させることによって、材料の浸食を少なくとも部分的に促進することができる。さらに、生体内分解性の材料を利用する場合、材料の多孔性によって、断片の大きさを確実に小さくすることができる。
多孔性の材料および多孔性の材料を作製する方法が、デートら（Ｄａｔｅ ｅｔ ａｌ．）によって（特許文献１４）に；ホシノら（Ｈｏｓｈｉｎｏ ｅｔ ａｌ．）によって（特許文献１５）に；かつステルツェルら（Ｓｔｅｒｚｅｌ ｅｔ ａｌ．）によって（特許文献１６）に記載されている。
本願明細書に記載するステントは、体内の所望の部位に、いくつかのカテーテルによる送達システム、例として、上記のバルーンカテーテルのシステムによって送達することができる。例示的なカテーテルのシステムが、（特許文献１７）、（特許文献１８）および（特許文献１９）に記載されている。ボストンサイエンティフィックサイメド社（Ｂｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ）［米国ミネソタ州メイプルグローブ（Ｍａｐｌｅ Ｇｒｏｖｅ）所在］から入手可能なＲａｄｉｕｓ（登録商標）システムおよびＳｙｍｂｉｏｔ（登録商標）システムもまた、カテーテルによる送達システムの例である。
本願明細書に記載するステントは、血管の管腔または血管でない管腔のために構成することができる。例えば、これらを、食道または前立腺において使用するために構成することができる。その他の管腔は、胆管の管腔、肝臓の管腔、膵臓の管腔、尿道の管腔および尿管の管腔を含む。
本願明細書に記載するいずれのステントも、染色しても、あるいは例えば、硫酸バリウム、白金もしくは金等の放射線を通さない材料の添加によってまたは放射線を通さない材料を用いて被覆することによって放射線を通さないようにしてもよい。
本願明細書に記載するいずれのステントも、または本願明細書に記載するいずれのステントのいずれの部分も、生体内分解性の材料または非生体内分解性の材料を用いて被覆することができる。例えば、被覆を使用して、薬物を送達すること、ステントの一部を保護すること、未制御の断片化を低減させること、および／またはステントもしくはステントの一部と管腔の一部との間の接触を阻止することができる。
その他の実施形態
いくつかの実施形態を説明してきた。にもかかわらず、種々の改変形態を、本開示の精神および範囲から逸脱することなく作製することができることが理解されるであろう。
ステントを示してきたが、その他の内部人工器官も可能である。例えば、内部人工器官は、ステント内挿型人工血管またはフィルターの形態であってもよい。
生体内分解性の本体が、ステントの長手方向の軸に沿って真横から見ると、横断面が環状である管の形態をとる（例えば、図２）実施形態を示してきたが、管は、環状でない横断面を有してもよい。例えば、管は、ステントの長手方向の軸に沿って真横から見ると、正方形、長方形、六角形または八角形であってもよい。
生体内分解性の領域が、生体内分解性の本体の外側表面から延出する実施形態を示し、領域が、生体内分解性の本体の外側表面を越えて内側に向かって延出する実施形態も示してきたが、いくつかの実施形態では、領域が、生体内分解性の本体の外側表面を越えて内側に向かっておよびそこから外側に向かっての両方に延出する。
明確な境界を有する生体内分解性の領域を示してきたが、いくつかの実施形態では、境界は、ＰＩＩＩを使用した場合に予想される境界等、より曖昧である。
単一の材料を含む生体内分解性の領域および本体を示してきたが、いくつかの実施形態では、それらは、複数の材料、例えば、材料のブレンドもしくは混合物または異なる材料の層を含む。
ここで図５に戻ってそれを参照すると、被覆１１０に加えて、ステントは、未被覆のステントの外側表面と被覆１１０との間に配置されたもう１つの被覆も含んでよい。この他方の被覆は、キレート化剤であっても、またはそれを含んでもよい。例えば、他方の被覆は、中に分散させたキレート化剤を含むポリマー性の被覆であってよい。キレート化剤は、例えば、ステントの本体の分解から生じたいずれかの金属イオンをキレート化して、治療剤の被覆１１０からの放出を金属イオンが妨げるのを阻止することができる。これは、例えば、キレートが、大き過ぎて被覆１１０内に拡散できない、またはキレートの溶解性が低過ぎて被覆内に拡散できないのいずれかであることによる。キレート化剤の例として、脂肪酸のナトリウム塩（例えば、通常のせっけん）、ＥＤＴＡおよびポルフィリンが挙げられる。
さらなるその他の実施形態も、以下の特許請求の範囲に属する。

Claims (18)

  1. 第１の生体内分解性の材料からなる生体内分解性の本体からなる埋込み型の内部人工器官であって、該生体内分解性の本体が、該第１の生体内分解性の材料とは異なる第２の生体内分解性の材料からなる、複数の別個の相隔たる生体内分解性の領域を担持する、埋込み型の内部人工器官。
  2. それぞれの別個の相隔たる領域が、前記生体内分解性の本体の外側表面から延出する、請求項１に記載の埋込み型の内部人工器官。
  3. 被覆が、治療剤を、その上に、その中にまたはそれらの組合せに含む、請求項３に記載の埋込み型の内部人工器官。
  4. それぞれの別個の相隔たる領域が、前記生体内分解性の本体の最も外側の表面を越えて内側に向かって延出する、請求項１に記載の埋込み型の内部人工器官。
  5. すぐに隣接している領域間の長手方向の間隔が、約１．０μｍと約３５μｍとの間であり；
    前記生体内分解性の本体の外側表面に沿って測定した場合、すぐに隣接している領域間の横方向の間隔が、約１．０μｍと約３５μｍとの間であり；
    前記生体内分解性の本体の厚さが、約０．５ｍｍから約５．０ｍｍまでであり；
    それぞれの領域の厚さが、約０．０１μｍから約５μｍまでであり；かつ
    それぞれの領域の最も外側の上端の表面が、約２５μｍ２以下の面積を有する、
    請求項２または４に記載の埋込み型の内部人工器官。
  6. 周りに被覆をさらに含む、請求項１または４に記載の埋込み型の内部人工器官。
  7. 前記生体内分解性の本体が、管の形態である、請求項１に記載の埋込み型の内部人工器官。
  8. 前記生体内分解性の本体が、生体内分解性の金属材料からなる、請求項１に記載の埋込み型の内部人工器官。
  9. 前記生体内分解性の金属材料が、鉄、マグネシウム、亜鉛、アルミニウム、カルシウムおよびそれらの合金からなる群から選択される、請求項８に記載の埋込み型の内部人工器官。
  10. 前記生体内分解性の本体およびそれぞれの領域が、生体内分解性の金属からなる、請求項１に記載の埋込み型の内部人工器官。
  11. 前記生体内分解性の本体およびそれぞれの領域が、一緒になってガルバニック対を画定し、かつ該ガルバニック対のための標準的な電池電位が、少なくとも＋１．０Ｖである、請求項１または１０に記載の埋込み型の内部人工器官。
  12. ステントの形態である、請求項１に記載の埋込み型の内部人工器官。
  13. 前記生体内分解性の本体、前記領域のうちの１つもしくは複数、またはそれらの組合せが、電池に電気的に接続される、請求項１に記載の埋込み型の内部人工器官。
  14. 約１μＡから約２５０μＡまでの電流が、前記生体内分解性の本体および電池、前記領域
    のうちの１つもしくは複数および電池、またはそれらの組合せからなる回路を通って流れる、請求項１４に記載の埋込み型の内部人工器官。
  15. 前記生体内分解性の本体の断片が生体内分解の間に内部人工器官から分離するのを実質的に阻止する被覆を、前記生体内分解性の本体の周りにさらに含む、請求項１に記載の埋込み型の内部人工器官。
  16. それぞれの別個の相隔たる領域が、前記生体内分解性の本体の最も外側の表面から延出し；かつ
    被覆が、相隔たる領域間に配置される、請求項１に記載の埋込み型の内部人工器官。
  17. 第１の生体内分解性の材料からなる生体内分解性の本体を提供する工程と；
    該第１の生体内分解性の材料とは異なる第２の生体内分解性の材料からなる、複数の別個の相隔たる生体内分解性の領域を形成し、それによって、該生体内分解性の本体が、該生体内分解性の領域を担持するようになす工程と
    からなる請求項１に記載の埋込み型の内部人工器官を作製する方法。
  18. 被覆を、前記生体内分解性の本体の少なくとも一部の上に形成する工程をさらに含む、請求項１７に記載の方法。
JP2009528478A 2006-09-18 2007-09-13 内部人工器官 Withdrawn JP2010503482A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84534106P 2006-09-18 2006-09-18
PCT/US2007/078411 WO2008036548A2 (en) 2006-09-18 2007-09-13 Endoprostheses

Publications (1)

Publication Number Publication Date
JP2010503482A true JP2010503482A (ja) 2010-02-04

Family

ID=39092033

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009528478A Withdrawn JP2010503482A (ja) 2006-09-18 2007-09-13 内部人工器官

Country Status (5)

Country Link
US (1) US8002821B2 (ja)
EP (1) EP2068962B1 (ja)
JP (1) JP2010503482A (ja)
CA (1) CA2663762A1 (ja)
WO (1) WO2008036548A2 (ja)

Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306166B1 (en) * 1997-08-13 2001-10-23 Scimed Life Systems, Inc. Loading and release of water-insoluble drugs
US7713297B2 (en) 1998-04-11 2010-05-11 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
US8458879B2 (en) * 2001-07-03 2013-06-11 Advanced Bio Prosthetic Surfaces, Ltd., A Wholly Owned Subsidiary Of Palmaz Scientific, Inc. Method of fabricating an implantable medical device
US7727221B2 (en) 2001-06-27 2010-06-01 Cardiac Pacemakers Inc. Method and device for electrochemical formation of therapeutic species in vivo
US11207457B2 (en) * 2004-08-27 2021-12-28 Edwards Lifesciences Corporation Device and method for establishing an artificial arterio-venous fistula
US20060276910A1 (en) * 2005-06-01 2006-12-07 Jan Weber Endoprostheses
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
US20070203564A1 (en) * 2006-02-28 2007-08-30 Boston Scientific Scimed, Inc. Biodegradable implants having accelerated biodegradation properties in vivo
US20070224235A1 (en) 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8187620B2 (en) 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
US8048150B2 (en) 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
CA2655793A1 (en) 2006-06-29 2008-01-03 Boston Scientific Limited Medical devices with selective coating
US8052743B2 (en) 2006-08-02 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis with three-dimensional disintegration control
EP2068757B1 (en) 2006-09-14 2011-05-11 Boston Scientific Limited Medical devices with drug-eluting coating
CA2663271A1 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprostheses and methods of making the same
WO2008034031A2 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprostheses and methods of making the same
WO2008034048A2 (en) * 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprosthesis with biostable inorganic layers
WO2008034013A2 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Medical devices and methods of making the same
WO2008036548A2 (en) 2006-09-18 2008-03-27 Boston Scientific Limited Endoprostheses
US7981150B2 (en) * 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
WO2008083190A2 (en) 2006-12-28 2008-07-10 Boston Scientific Limited Bioerodible endoprostheses and methods of making same
BRPI0806727B8 (pt) 2007-01-21 2021-06-22 Hemoteq Ag método para o revestimento de um cateter de balão
US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
US7976915B2 (en) 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
US8002823B2 (en) * 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7942926B2 (en) 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
US9284409B2 (en) 2007-07-19 2016-03-15 Boston Scientific Scimed, Inc. Endoprosthesis having a non-fouling surface
DE102007034363A1 (de) * 2007-07-24 2009-01-29 Biotronik Vi Patent Ag Endoprothese
US8815273B2 (en) 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
WO2009018340A2 (en) 2007-07-31 2009-02-05 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
EP2185103B1 (en) 2007-08-03 2014-02-12 Boston Scientific Scimed, Inc. Coating for medical device having increased surface area
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
US8029554B2 (en) 2007-11-02 2011-10-04 Boston Scientific Scimed, Inc. Stent with embedded material
US7938855B2 (en) 2007-11-02 2011-05-10 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8118857B2 (en) * 2007-11-29 2012-02-21 Boston Scientific Corporation Medical articles that stimulate endothelial cell migration
JP5581311B2 (ja) 2008-04-22 2014-08-27 ボストン サイエンティフィック サイムド，インコーポレイテッド 無機材料のコーティングを有する医療デバイス及びその製造方法
WO2009132176A2 (en) 2008-04-24 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
US20090287301A1 (en) * 2008-05-16 2009-11-19 Boston Scientific, Scimed Inc. Coating for medical implants
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US8449603B2 (en) 2008-06-18 2013-05-28 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7985252B2 (en) * 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
US20100125325A1 (en) * 2008-11-20 2010-05-20 Medtronic Vascular, Inc. Stent With Cathodic Protection and Stent Delivery System
US8231980B2 (en) 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
US20100217370A1 (en) * 2009-02-20 2010-08-26 Boston Scientific Scimed, Inc. Bioerodible Endoprosthesis
EP2403546A2 (en) 2009-03-02 2012-01-11 Boston Scientific Scimed, Inc. Self-buffering medical implants
US8071156B2 (en) 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
AU2010239605B2 (en) * 2009-04-20 2014-06-26 Rox Medical, Inc. Device and method for establishing an artificial arterio-venous fistula
KR20100116566A (ko) * 2009-04-22 2010-11-01 유앤아이 주식회사 생체분해성 임플란트 및 이의 제조방법
EP2421571A2 (en) * 2009-04-24 2012-02-29 Boston Scientific Scimed, Inc. Use of drug polymorphs to achieve controlled drug delivery from a coated medical device
US8287937B2 (en) 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
ES2550634T3 (es) * 2009-07-10 2015-11-11 Boston Scientific Scimed, Inc. Uso de nanocristales para un balón de suministro de fármaco
JP5933434B2 (ja) * 2009-07-17 2016-06-08 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 薬剤送達バルーンの製造方法
US10240419B2 (en) 2009-12-08 2019-03-26 Baker Hughes, A Ge Company, Llc Downhole flow inhibition tool and method of unplugging a seat
US20110160839A1 (en) * 2009-12-29 2011-06-30 Boston Scientific Scimed, Inc. Endoprosthesis
EP2533698B1 (en) 2010-02-11 2018-03-28 Boston Scientific Scimed, Inc. Automatic vascular closure deployment devices
WO2011119573A1 (en) 2010-03-23 2011-09-29 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
US9072618B2 (en) * 2010-05-06 2015-07-07 Biotronik Ag Biocorrodable implant in which corrosion may be triggered or accelerated after implantation by means of an external stimulus
US9414821B2 (en) 2010-07-22 2016-08-16 Boston Scientific Scimed, Inc. Vascular closure device with biodegradable anchor
EP2422827B1 (en) * 2010-08-27 2019-01-30 Biotronik AG Stent with a surface layer having a topographic modification
US8889211B2 (en) 2010-09-02 2014-11-18 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
EP2629832A1 (en) 2010-10-18 2013-08-28 Boston Scientific Scimed, Inc. Drug eluting medical device utilizing bioadhesives
US8758402B2 (en) 2010-12-17 2014-06-24 Boston Scientific Scimed, Inc. Tissue puncture closure device
US9707739B2 (en) 2011-07-22 2017-07-18 Baker Hughes Incorporated Intermetallic metallic composite, method of manufacture thereof and articles comprising the same
US8669360B2 (en) 2011-08-05 2014-03-11 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
US9033055B2 (en) 2011-08-17 2015-05-19 Baker Hughes Incorporated Selectively degradable passage restriction and method
US9056152B2 (en) 2011-08-25 2015-06-16 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
US9090956B2 (en) 2011-08-30 2015-07-28 Baker Hughes Incorporated Aluminum alloy powder metal compact
US9010416B2 (en) 2012-01-25 2015-04-21 Baker Hughes Incorporated Tubular anchoring system and a seat for use in the same
WO2013163747A1 (en) 2012-05-02 2013-11-07 The Royal Institution For The Advancement Of Learning/Mcgill University Bioresorbable medical devices and method of manufacturing the same
US10736995B2 (en) 2012-05-02 2020-08-11 Les Entreprises Nanostent Inc. Bioresorbable medical devices and method of manufacturing the same
EP3900648A1 (en) 2012-07-13 2021-10-27 Boston Scientific Scimed, Inc. Occlusion device for an atrial appendage
WO2014042875A1 (en) 2012-09-12 2014-03-20 Boston Scientific Scimed, Inc. Adhesive stent coating for anti-migration
EP2911712B1 (en) 2012-10-25 2017-11-29 Boston Scientific Scimed, Inc. Stent having a tacky silicone coating to prevent stent migration
US11298442B2 (en) 2013-08-08 2022-04-12 Boston Scientific Scimed, Inc. Dissolvable or degradable adhesive polymer to prevent stent migration
US9816339B2 (en) 2013-09-03 2017-11-14 Baker Hughes, A Ge Company, Llc Plug reception assembly and method of reducing restriction in a borehole
WO2015073704A1 (en) 2013-11-13 2015-05-21 Covidien Lp Galvanically assisted attachment of medical devices to thrombus
US11167343B2 (en) 2014-02-21 2021-11-09 Terves, Llc Galvanically-active in situ formed particles for controlled rate dissolving tools
CA2936851A1 (en) 2014-02-21 2015-08-27 Terves, Inc. Fluid activated disintegrating metal system
EP3128960A1 (en) 2014-04-08 2017-02-15 Boston Scientific Scimed, Inc. Partially coated stents
US20150297803A1 (en) * 2014-04-22 2015-10-22 Medtronic Vascular, Inc. Bioerodible Stent
US11274362B2 (en) * 2014-08-29 2022-03-15 Toufic Azar Bioresorbable materials, bioresorbable medical devices, bioresorbable coatings for implantable medical devices and method of manufacturing the same using vapor deposition
US10378303B2 (en) 2015-03-05 2019-08-13 Baker Hughes, A Ge Company, Llc Downhole tool and method of forming the same
US10265515B2 (en) 2015-03-27 2019-04-23 Covidien Lp Galvanically assisted aneurysm treatment
US10667896B2 (en) 2015-11-13 2020-06-02 Cardiac Pacemakers, Inc. Bioabsorbable left atrial appendage closure with endothelialization promoting surface
CA3012511A1 (en) 2017-07-27 2019-01-27 Terves Inc. Degradable metal matrix composite
US11338135B2 (en) 2017-10-23 2022-05-24 Cardiac Pacemakers, Inc. Medical devices for cancer therapy with electric field shaping elements
CN111867490B (zh) 2018-02-14 2024-01-30 波士顿科学医学有限公司 闭塞医疗装置
CN113727753A (zh) 2019-04-22 2021-11-30 波士顿科学国际有限公司 用于癌症治疗的电刺激装置
EP3958959B1 (en) 2019-04-22 2024-04-24 Boston Scientific Scimed Inc. Devices for administering electrical stimulation to treat cancer
JP2022529374A (ja) * 2019-04-23 2022-06-21 ボストン サイエンティフィック サイムド，インコーポレイテッド がん治療のための電気刺激用電極
US11607542B2 (en) 2019-04-23 2023-03-21 Boston Scientific Scimed, Inc. Electrical stimulation for cancer treatment with internal and external electrodes
EP3958960A1 (en) 2019-04-23 2022-03-02 Boston Scientific Scimed Inc. Electrical stimulation with thermal treatment or thermal monitoring
WO2021173509A1 (en) 2020-02-24 2021-09-02 Boston Scientific Scimed, Inc. Systems and methods for treatment of pancreatic cancer
CN116173299B (zh) * 2023-04-26 2023-08-18 泓欣科创(北京)科技有限公司 可降解植入物及可降解植入物的制造方法

Family Cites Families (1071)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2950187A (en) 1958-09-05 1960-08-23 Res Inst Iron Steel Iron-calcium base alloy
GB1237035A (en) 1969-08-20 1971-06-30 Tsi Travmatologii I Ortopedii Magnesium-base alloy for use in bone surgery
US3758396A (en) 1971-08-31 1973-09-11 Research Corp Ition preparation of immobilized enzymemembrane complexes by electrocodepos
US3948254A (en) 1971-11-08 1976-04-06 Alza Corporation Novel drug delivery device
US3868578A (en) * 1972-10-02 1975-02-25 Canadian Patents Dev Method and apparatus for electroanalysis
US3910819A (en) 1974-02-19 1975-10-07 California Inst Of Techn Treatment of surfaces to stimulate biological cell adhesion and growth
US3993072A (en) 1974-08-28 1976-11-23 Alza Corporation Microporous drug delivery device
US3952334A (en) 1974-11-29 1976-04-27 General Atomic Company Biocompatible carbon prosthetic devices
US4101984A (en) 1975-05-09 1978-07-25 Macgregor David C Cardiovascular prosthetic devices and implants with porous systems
DE2620907C3 (de) 1976-05-12 1984-09-20 Battelle-Institut E.V., 6000 Frankfurt Verankerung für hochbelastete Endoprothesen
US4143661A (en) 1977-12-12 1979-03-13 Andros Incorporated Power supply for body implant and method for operation
DE2827529C2 (de) 1978-06-23 1982-09-30 Battelle-Institut E.V., 6000 Frankfurt Implantierbarer Knochenersatzwerkstoff bestehend aus einem Metallkern und aus bioaktiven, gesinterten Calciumphosphat-Keramik-Partikeln und ein Verfahren zu seiner Herstellung
US4713070A (en) 1978-11-30 1987-12-15 Sumitom Electric Industries, Ltd. Porous structure of polytetrafluoroethylene and process for production thereof
US4237559A (en) 1979-05-11 1980-12-09 General Electric Company Bone implant embodying a composite high and low density fired ceramic construction
US4334327A (en) 1979-12-21 1982-06-15 University Of Utah Ureteral prosthesis
US4308868A (en) * 1980-05-27 1982-01-05 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Implantable electrical device
CH649578A5 (de) 1981-03-27 1985-05-31 Ulvac Corp Hochgeschwindigkeits-kathoden-zerstaeubungsvorrichtung.
US4542539A (en) 1982-03-12 1985-09-24 Artech Corp. Surgical implant having a graded porous coating
SE445884B (sv) 1982-04-30 1986-07-28 Medinvent Sa Anordning for implantation av en rorformig protes
US4539061A (en) 1983-09-07 1985-09-03 Yeda Research And Development Co., Ltd. Process for the production of built-up films by the stepwise adsorption of individual monolayers
US4657544A (en) 1984-04-18 1987-04-14 Cordis Corporation Cardiovascular graft and method of forming same
US5938903A (en) 1984-05-09 1999-08-17 Research Foundation Of The City University Of New York Microelectrodes and their use in an electrochemical arrangement with telemetric application
US4532929A (en) 1984-07-23 1985-08-06 Ethicon, Inc. Dry coating of surgical filaments
US4565896A (en) * 1984-10-22 1986-01-21 Texaco Inc. Process for low pressure synthesis of ethylene glycol from synthesis gas
US4634502A (en) * 1984-11-02 1987-01-06 The Standard Oil Company Process for the reductive deposition of polyoxometallates
US4585652A (en) 1984-11-19 1986-04-29 Regents Of The University Of Minnesota Electrochemical controlled release drug delivery system
US4665896A (en) 1985-07-22 1987-05-19 Novacor Medical Corporation Power supply for body implant and method of use
EP0216149B1 (en) * 1985-08-23 1991-12-04 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Artificial vessel having excellent patency
US4705502A (en) 1985-11-06 1987-11-10 The Kendall Company Suprapubic catheter with dual balloons
US4733665C2 (en) 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4767418A (en) 1986-02-13 1988-08-30 California Institute Of Technology Luminal surface fabrication for cardiovascular prostheses
DE3608158A1 (de) 1986-03-12 1987-09-17 Braun Melsungen Ag Mit vernetzter gelatine impraegnierte gefaessprothese und verfahren zu ihrer herstellung
SE453258B (sv) 1986-04-21 1988-01-25 Medinvent Sa Elastisk, sjelvexpanderande protes samt forfarande for dess framstellning
CH670760A5 (ja) * 1986-06-02 1989-07-14 Sulzer Ag
US4800882A (en) * 1987-03-13 1989-01-31 Cook Incorporated Endovascular stent and delivery system
US4827940A (en) 1987-04-13 1989-05-09 Cardiac Pacemakers, Inc. Soluble covering for cardiac pacing electrode
US5059211A (en) 1987-06-25 1991-10-22 Duke University Absorbable vascular stent
US5527337A (en) 1987-06-25 1996-06-18 Duke University Bioabsorbable stent and method of making the same
US4886062A (en) 1987-10-19 1989-12-12 Medtronic, Inc. Intravascular radially expandable stent and method of implant
US5091205A (en) 1989-01-17 1992-02-25 Union Carbide Chemicals & Plastics Technology Corporation Hydrophilic lubricious coatings
CH678393A5 (ja) 1989-01-26 1991-09-13 Ulrich Prof Dr Med Sigwart
US5163958A (en) 1989-02-02 1992-11-17 Cordis Corporation Carbon coated tubular endoprosthesis
US4994071A (en) 1989-05-22 1991-02-19 Cordis Corporation Bifurcating stent apparatus and method
US5073365A (en) 1989-06-01 1991-12-17 Advanced Polymer Systems Clinical and personal care articles enhanced by lubricants and adjuvants
US5061914A (en) 1989-06-27 1991-10-29 Tini Alloy Company Shape-memory alloy micro-actuator
EP0405556B1 (en) 1989-06-30 1996-05-22 TDK Corporation Living hard tissue replacement, its preparation, and preparation of integral body
US5091024A (en) 1989-07-13 1992-02-25 Carpenter Technology Corporation Corrosion resistant, magnetic alloy article
US5611347A (en) 1989-07-25 1997-03-18 Smith & Nephew, Inc. Zirconium oxide and zirconium nitride coated percutaneous devices
ES2043289T3 (es) 1989-09-25 1993-12-16 Schneider Usa Inc La extrusion de capas multiples como procedimiento para hacer balones de angioplastia.
US5439446A (en) 1994-06-30 1995-08-08 Boston Scientific Corporation Stent and therapeutic delivery system
US5843089A (en) 1990-12-28 1998-12-01 Boston Scientific Corporation Stent lining
US5304121A (en) 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
US5674192A (en) 1990-12-28 1997-10-07 Boston Scientific Corporation Drug delivery
US5477864A (en) 1989-12-21 1995-12-26 Smith & Nephew Richards, Inc. Cardiovascular guidewire of enhanced biocompatibility
US5545208A (en) 1990-02-28 1996-08-13 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5236413B1 (en) 1990-05-07 1996-06-18 Andrew J Feiring Method and apparatus for inducing the permeation of medication into internal tissue
EP0484533B1 (en) 1990-05-19 1995-01-25 Anatoly Nikiforovich Papyrin Method and device for coating
US5079203A (en) * 1990-05-25 1992-01-07 Board Of Trustees Operating Michigan State University Polyoxometalate intercalated layered double hydroxides
US5587507A (en) 1995-03-31 1996-12-24 Rutgers, The State University Synthesis of tyrosine derived diphenol monomers
US5120322A (en) 1990-06-13 1992-06-09 Lathrotec, Inc. Method and apparatus for treatment of fibrotic lesions
US5102403A (en) 1990-06-18 1992-04-07 Eckhard Alt Therapeutic medical instrument for insertion into body
US5236447A (en) 1990-06-29 1993-08-17 Nissho Corporation Artificial tubular organ
US5549664A (en) 1990-07-31 1996-08-27 Ube Industries, Ltd. Artificial blood vessel
US4976692A (en) 1990-09-13 1990-12-11 Travenol Laboratories (Israel) Ltd. Catheter particularly useful for inducing labor and/or for the application of a pharmaceutical substance to the cervix of the uterus
US5160790A (en) 1990-11-01 1992-11-03 C. R. Bard, Inc. Lubricious hydrogel coatings
US6524274B1 (en) 1990-12-28 2003-02-25 Scimed Life Systems, Inc. Triggered release hydrogel drug delivery system
US5205921A (en) 1991-02-04 1993-04-27 Queen's University At Kingston Method for depositing bioactive coatings on conductive substrates
DE4104359A1 (de) * 1991-02-13 1992-08-20 Implex Gmbh Ladesystem fuer implantierbare hoerhilfen und tinnitus-maskierer
USRE38653E1 (en) 1991-03-08 2004-11-16 Kabushikikaisha Igaki Iryo Sekkei Luminal stent, holding structure therefor and device for attaching luminal stent
US5195969A (en) 1991-04-26 1993-03-23 Boston Scientific Corporation Co-extruded medical balloons and catheter using such balloons
US5147370A (en) 1991-06-12 1992-09-15 Mcnamara Thomas O Nitinol stent for hollow body conduits
US5258098A (en) 1991-06-17 1993-11-02 Cycam, Inc. Method of production of a surface adapted to promote adhesion
US5292558A (en) 1991-08-08 1994-03-08 University Of Texas At Austin, Texas Process for metal deposition for microelectronic interconnections
US5356433A (en) 1991-08-13 1994-10-18 Cordis Corporation Biocompatible metal surfaces
US6107004A (en) 1991-09-05 2000-08-22 Intra Therapeutics, Inc. Method for making a tubular stent for use in medical applications
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
WO1993006792A1 (en) 1991-10-04 1993-04-15 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
US5500013A (en) 1991-10-04 1996-03-19 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
US5464450A (en) 1991-10-04 1995-11-07 Scimed Lifesystems Inc. Biodegradable drug delivery vascular stent
US5234457A (en) 1991-10-09 1993-08-10 Boston Scientific Corporation Impregnated stent
US5366504A (en) 1992-05-20 1994-11-22 Boston Scientific Corporation Tubular medical prosthesis
JP2961287B2 (ja) * 1991-10-18 1999-10-12 グンゼ株式会社 生体管路拡張具、その製造方法およびステント
WO1993007924A1 (en) 1991-10-18 1993-04-29 Spire Corporation Bactericidal coatings for implants
CA2079417C (en) 1991-10-28 2003-01-07 Lilip Lau Expandable stents and method of making same
US5314453A (en) 1991-12-06 1994-05-24 Spinal Cord Society Position sensitive power transfer antenna
DK0791333T3 (da) 1991-12-12 2000-05-01 Target Therapeutics Inc Adskillelig udstøder-karokklusionsspiralkonstruktion med sammenlåsende kobling
US5348553A (en) 1991-12-18 1994-09-20 Whitney Douglass G Method for promoting blood vessel healing
US5193540A (en) 1991-12-18 1993-03-16 Alfred E. Mann Foundation For Scientific Research Structure and method of manufacture of an implantable microstimulator
US5360440A (en) 1992-03-09 1994-11-01 Boston Scientific Corporation In situ apparatus for generating an electrical current in a biological environment
US5282823A (en) 1992-03-19 1994-02-01 Medtronic, Inc. Intravascular radially expandable stent
US5599352A (en) 1992-03-19 1997-02-04 Medtronic, Inc. Method of making a drug eluting stent
EP0566245B1 (en) 1992-03-19 1999-10-06 Medtronic, Inc. Intraluminal stent
US5591224A (en) * 1992-03-19 1997-01-07 Medtronic, Inc. Bioelastomeric stent
JPH07505316A (ja) 1992-03-31 1995-06-15 ボストン　サイエンティフィック　コーポレーション 医療用ワイヤ
US5779904A (en) 1992-03-31 1998-07-14 Inrad Synthesis of inorganic membranes on supports
GEP20002074B (en) 1992-05-19 2000-05-10 Westaim Tech Inc Ca Modified Material and Method for its Production
CA2074318A1 (en) * 1992-07-22 1994-01-23 Morteza Shirkhanzadeh Prosthetic implant with self-generated current for early fixation in skeletal bone
US5614549A (en) 1992-08-21 1997-03-25 Enzon, Inc. High molecular weight polymer-based prodrugs
US5447533A (en) 1992-09-03 1995-09-05 Pacesetter, Inc. Implantable stimulation lead having an advanceable therapeutic drug delivery system
US5458627A (en) 1992-10-15 1995-10-17 Electro-Biology, Inc. Electrochemically controlled faradic stimulation of osteogenesis
US5578075B1 (en) 1992-11-04 2000-02-08 Daynke Res Inc Minimally invasive bioactivated endoprosthesis for vessel repair
US5449382A (en) 1992-11-04 1995-09-12 Dayton; Michael P. Minimally invasive bioactivated endoprosthesis for vessel repair
US5322520A (en) 1992-11-12 1994-06-21 Implemed, Inc. Iontophoretic structure for medical devices
US5385776A (en) * 1992-11-16 1995-01-31 Alliedsignal Inc. Nanocomposites of gamma phase polymers containing inorganic particulate material
US5342348A (en) 1992-12-04 1994-08-30 Kaplan Aaron V Method and device for treating and enlarging body lumens
US5443458A (en) 1992-12-22 1995-08-22 Advanced Cardiovascular Systems, Inc. Multilayered biodegradable stent and method of manufacture
ATE207728T1 (de) 1993-01-19 2001-11-15 Schneider Usa Inc Implantierbarer draht in verbundbauweise
US5607463A (en) 1993-03-30 1997-03-04 Medtronic, Inc. Intravascular medical device
US5380298A (en) * 1993-04-07 1995-01-10 The United States Of America As Represented By The Secretary Of The Navy Medical device with infection preventing feature
US5464650A (en) 1993-04-26 1995-11-07 Medtronic, Inc. Intravascular stent and method
US5824048A (en) 1993-04-26 1998-10-20 Medtronic, Inc. Method for delivering a therapeutic substance to a body lumen
US5518767A (en) 1993-07-01 1996-05-21 Massachusetts Institute Of Technology Molecular self-assembly of electrically conductive polymers
US5994341A (en) 1993-07-19 1999-11-30 Angiogenesis Technologies, Inc. Anti-angiogenic Compositions and methods for the treatment of arthritis
US20030203976A1 (en) * 1993-07-19 2003-10-30 William L. Hunter Anti-angiogenic compositions and methods of use
AU693779B2 (en) 1993-07-23 1998-07-09 Cook Medical Technologies Llc A flexible stent having a pattern formed from a sheet of material
US6776094B1 (en) 1993-10-04 2004-08-17 President & Fellows Of Harvard College Kit For Microcontact Printing
US5776748A (en) 1993-10-04 1998-07-07 President And Fellows Of Harvard College Method of formation of microstamped patterns on plates for adhesion of cells and other biological materials, devices and uses therefor
US6176874B1 (en) 1993-10-18 2001-01-23 Masschusetts Institute Of Technology Vascularized tissue regeneration matrices formed by solid free form fabrication techniques
US5397307A (en) 1993-12-07 1995-03-14 Schneider (Usa) Inc. Drug delivery PTCA catheter and method for drug delivery
US5462575A (en) 1993-12-23 1995-10-31 Crs Holding, Inc. Co-Cr-Mo powder metallurgy articles and process for their manufacture
US5788687A (en) 1994-02-01 1998-08-04 Caphco, Inc Compositions and devices for controlled release of active ingredients
US5449373A (en) 1994-03-17 1995-09-12 Medinol Ltd. Articulated stent
JPH07257079A (ja) 1994-03-25 1995-10-09 Dainippon Printing Co Ltd 光カード
DE69527141T2 (de) 1994-04-29 2002-11-07 Scimed Life Systems Inc Stent mit kollagen
US5468574A (en) 1994-05-23 1995-11-21 Dais Corporation Fuel cell incorporating novel ion-conducting membrane
US6185457B1 (en) 1994-05-31 2001-02-06 Galvani, Ltd. Method and apparatus for electrically forcing cardiac output in an arrhythmia patient
US5629077A (en) 1994-06-27 1997-05-13 Advanced Cardiovascular Systems, Inc. Biodegradable mesh and film stent
US5788979A (en) 1994-07-22 1998-08-04 Inflow Dynamics Inc. Biodegradable coating with inhibitory properties for application to biocompatible materials
US5891108A (en) 1994-09-12 1999-04-06 Cordis Corporation Drug delivery stent
US5649977A (en) 1994-09-22 1997-07-22 Advanced Cardiovascular Systems, Inc. Metal reinforced polymer stent
US5773925A (en) 1994-10-24 1998-06-30 Sony Corporation Electron gun for a cathode ray tube
DE4440386A1 (de) 1994-11-11 1996-05-15 Pacesetter Ab Elektroden für medizinische Anwendungen
CA2301351C (en) 1994-11-28 2002-01-22 Advanced Cardiovascular Systems, Inc. Method and apparatus for direct laser cutting of metal stents
US5637113A (en) 1994-12-13 1997-06-10 Advanced Cardiovascular Systems, Inc. Polymer film for wrapping a stent structure
US5755722A (en) 1994-12-22 1998-05-26 Boston Scientific Corporation Stent placement device with medication dispenser and method
US6017577A (en) * 1995-02-01 2000-01-25 Schneider (Usa) Inc. Slippery, tenaciously adhering hydrophilic polyurethane hydrogel coatings, coated polymer substrate materials, and coated medical devices
US7204848B1 (en) 1995-03-01 2007-04-17 Boston Scientific Scimed, Inc. Longitudinally flexible expandable stent
US6124523A (en) 1995-03-10 2000-09-26 Impra, Inc. Encapsulated stent
US6306144B1 (en) 1996-11-01 2001-10-23 Scimed Life Systems, Inc. Selective coating of a balloon catheter with lubricious material for stent deployment
US5605696A (en) 1995-03-30 1997-02-25 Advanced Cardiovascular Systems, Inc. Drug loaded polymeric material and method of manufacture
DE69619179T2 (de) 1995-04-03 2002-08-22 Mitsubishi Materials Corp Poröser metallischer körper mit höher spezifischer oberfläche, verfahren zu dessen herstellung, poröses metallisches material und elektrode für alkalische sekundärbatterie
JPH10506560A (ja) 1995-04-19 1998-06-30 シュナイダー（ユーエスエー）インク 薬品を放出する被覆されたステント
US6099562A (en) 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
US6132463A (en) 1995-05-19 2000-10-17 Etex Corporation Cell seeding of ceramic compositions
US6027742A (en) 1995-05-19 2000-02-22 Etex Corporation Bioresorbable ceramic composites
AU720963B2 (en) 1995-05-26 2000-06-15 Surmodics, Inc. Method and implantable article for promoting endothelialization
US5674242A (en) 1995-06-06 1997-10-07 Quanam Medical Corporation Endoprosthetic device with therapeutic compound
US7550005B2 (en) 1995-06-07 2009-06-23 Cook Incorporated Coated implantable medical device
US6774278B1 (en) 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
CA2178541C (en) 1995-06-07 2009-11-24 Neal E. Fearnot Implantable medical device
US5609629A (en) 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
US5676685A (en) 1995-06-22 1997-10-14 Razavi; Ali Temporary stent
US5840387A (en) 1995-07-28 1998-11-24 Aegis Biosciences L.L.C. Sulfonated multiblock copolymer and uses therefor
AU714311B2 (en) 1995-09-01 1999-12-23 Warsaw Orthopedic, Inc. An artificial stabilized composition of calcium phosphate phases particularly adapted for supporting bone cell activity
EP0765660A3 (en) 1995-09-28 1998-09-23 Takeda Chemical Industries, Ltd. Microcapsules comprising 2-piperazinone-1-acetic acid compounds
AU7254496A (en) 1995-09-29 1997-04-17 Becton Dickinson & Company Low-cost electrodes for an iontophoretic device
CA2204615C (en) 1995-09-29 2003-10-07 Michael F. Hess Adaptive search av and auto pvarp adaptation to same with additional benefit
US5758562A (en) 1995-10-11 1998-06-02 Schneider (Usa) Inc. Process for manufacturing braided composite prosthesis
DE19539449A1 (de) 1995-10-24 1997-04-30 Biotronik Mess & Therapieg Verfahren zur Herstellung intraluminaler Stents aus bioresorbierbarem Polymermaterial
US5603556A (en) 1995-11-20 1997-02-18 Technical Services And Marketing, Inc. Rail car load sensor
US5788626A (en) 1995-11-21 1998-08-04 Schneider (Usa) Inc Method of making a stent-graft covered with expanded polytetrafluoroethylene
DE19544750A1 (de) 1995-11-30 1997-06-05 Christoph Rehberg Implantierbare Vorrichtung mit Innenelektrode zur Förderung des Gewebewachstums
US5658327A (en) 1995-12-19 1997-08-19 Ventritex, Inc. Intracardiac lead having a compliant fixation device
US5800512A (en) 1996-01-22 1998-09-01 Meadox Medicals, Inc. PTFE vascular graft
DE69716779T2 (de) 1996-01-30 2003-07-17 Medtronic Inc Produkte und verfahren zur herstellung von dilatatoren
US5672242A (en) 1996-01-31 1997-09-30 Integrated Device Technology, Inc. High selectivity nitride to oxide etch process
US6051017A (en) 1996-02-20 2000-04-18 Advanced Bionics Corporation Implantable microstimulator and systems employing the same
US5951458A (en) 1996-02-29 1999-09-14 Scimed Life Systems, Inc. Local application of oxidizing agents to prevent restenosis
US6441025B2 (en) 1996-03-12 2002-08-27 Pg-Txl Company, L.P. Water soluble paclitaxel derivatives
CA2199890C (en) 1996-03-26 2002-02-05 Leonard Pinchuk Stents and stent-grafts having enhanced hoop strength and methods of making the same
US5976454A (en) 1996-04-01 1999-11-02 Basf Aktiengesellschaft Process for producing open-celled, inorganic sintered foam products
US5880661A (en) 1996-04-01 1999-03-09 Emf Therapeutics, Inc. Complex magnetic field generating device
US6783543B2 (en) 2000-06-05 2004-08-31 Scimed Life Systems, Inc. Intravascular stent with increasing coating retaining capacity
US20040106985A1 (en) 1996-04-26 2004-06-03 Jang G. David Intravascular stent
US5922021A (en) 1996-04-26 1999-07-13 Jang; G. David Intravascular stent
US6592617B2 (en) 1996-04-30 2003-07-15 Boston Scientific Scimed, Inc. Three-dimensional braided covered stent
US5891191A (en) 1996-04-30 1999-04-06 Schneider (Usa) Inc Cobalt-chromium-molybdenum alloy stent and stent-graft
US5951881A (en) 1996-07-22 1999-09-14 President And Fellows Of Harvard College Fabrication of small-scale cylindrical articles
US5693928A (en) 1996-06-27 1997-12-02 International Business Machines Corporation Method for producing a diffusion barrier and polymeric article having a diffusion barrier
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US6253252B1 (en) 1996-07-11 2001-06-26 Andrew Schofield Method and apparatus for asynchronously calling and implementing objects
US5941843A (en) 1996-07-12 1999-08-24 Empi, Inc. Iontophoresis electrode
US5741331A (en) 1996-07-29 1998-04-21 Corvita Corporation Biostable elastomeric polymers having quaternary carbons
US6120535A (en) 1996-07-29 2000-09-19 Radiance Medical Systems, Inc. Microporous tubular prosthesis
US5830217A (en) 1996-08-09 1998-11-03 Thomas J. Fogarty Soluble fixation device and method for stent delivery catheters
US6174329B1 (en) * 1996-08-22 2001-01-16 Advanced Cardiovascular Systems, Inc. Protective coating for a stent with intermediate radiopaque coating
US6756060B1 (en) 1996-09-19 2004-06-29 Usbiomaterials Corp. Anti-inflammatory and antimicrobial uses for bioactive glass compositions
US6953594B2 (en) 1996-10-10 2005-10-11 Etex Corporation Method of preparing a poorly crystalline calcium phosphate and methods of its use
DE69738398T2 (de) 1996-10-16 2008-12-04 Etex Corp., Cambridge Biokeramische zusammensetzung
US5761775A (en) 1996-10-17 1998-06-09 Legome; Mark J. Mushroom and loop material closure system for high shear strength and low peel strength applications
US6387121B1 (en) 1996-10-21 2002-05-14 Inflow Dynamics Inc. Vascular and endoluminal stents with improved coatings
US5824045A (en) 1996-10-21 1998-10-20 Inflow Dynamics Inc. Vascular and endoluminal stents
US6099561A (en) 1996-10-21 2000-08-08 Inflow Dynamics, Inc. Vascular and endoluminal stents with improved coatings
US6530951B1 (en) 1996-10-24 2003-03-11 Cook Incorporated Silver implantable medical device
US5869141A (en) 1996-11-04 1999-02-09 The Boeing Company Surface pretreatment for sol coating of metals
US6106473A (en) 1996-11-06 2000-08-22 Sts Biopolymers, Inc. Echogenic coatings
DE69737208T2 (de) 1996-11-15 2007-11-08 Cook Inc., Bloomington Stentanbringungsvorrichtung mit einer auftrennbaren hülle
US6114099A (en) 1996-11-21 2000-09-05 Virginia Tech Intellectual Properties, Inc. Patterned molecular self-assembly
ZA9710342B (en) 1996-11-25 1998-06-10 Alza Corp Directional drug delivery stent and method of use.
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
US6021347A (en) 1996-12-05 2000-02-01 Herbst; Ewa Electrochemical treatment of malignant tumors
US6251980B1 (en) 1996-12-06 2001-06-26 Amcol International Corporation Nanocomposites formed by onium ion-intercalated clay and rigid anhydride-cured epoxy resins
US5871437A (en) 1996-12-10 1999-02-16 Inflow Dynamics, Inc. Radioactive stent for treating blood vessels to prevent restenosis
US5906759A (en) 1996-12-26 1999-05-25 Medinol Ltd. Stent forming apparatus with stent deforming blades
IT1289815B1 (it) 1996-12-30 1998-10-16 Sorin Biomedica Cardio Spa Stent per angioplastica e relativo procedimento di produzione
US6013591A (en) * 1997-01-16 2000-01-11 Massachusetts Institute Of Technology Nanocrystalline apatites and composites, prostheses incorporating them, and method for their production
US5858556A (en) * 1997-01-21 1999-01-12 Uti Corporation Multilayer composite tubular structure and method of making
DE69831935T2 (de) 1997-01-24 2006-07-27 Paragon Intellectual Properties, LLC, Charleston Bistabiler federaufbau für ein stent
US8663311B2 (en) 1997-01-24 2014-03-04 Celonova Stent, Inc. Device comprising biodegradable bistable or multistable cells and methods of use
WO1998034673A1 (en) 1997-02-12 1998-08-13 Prolifix Medical, Inc. Apparatus for removal of material from stents
US6164284A (en) 1997-02-26 2000-12-26 Schulman; Joseph H. System of implantable devices for monitoring and/or affecting body parameters
US20020133222A1 (en) 1997-03-05 2002-09-19 Das Gladwin S. Expandable stent having a plurality of interconnected expansion modules
WO1998038947A1 (en) 1997-03-05 1998-09-11 Scimed Life Systems, Inc. Conformal laminate stent device
US5830229A (en) 1997-03-07 1998-11-03 Micro Therapeutics Inc. Hoop stent
US5815904A (en) 1997-03-13 1998-10-06 Intratherapeutics, Inc. Method for making a stent
US5977204A (en) 1997-04-11 1999-11-02 Osteobiologics, Inc. Biodegradable implant material comprising bioactive ceramic
US8172897B2 (en) 1997-04-15 2012-05-08 Advanced Cardiovascular Systems, Inc. Polymer and metal composite implantable medical devices
US5843172A (en) 1997-04-15 1998-12-01 Advanced Cardiovascular Systems, Inc. Porous medicated stent
US10028851B2 (en) 1997-04-15 2018-07-24 Advanced Cardiovascular Systems, Inc. Coatings for controlling erosion of a substrate of an implantable medical device
US6240616B1 (en) 1997-04-15 2001-06-05 Advanced Cardiovascular Systems, Inc. Method of manufacturing a medicated porous metal prosthesis
US6273913B1 (en) 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
IT1292295B1 (it) 1997-04-29 1999-01-29 Sorin Biomedica Cardio Spa Stent per angioplastica
US5879697A (en) 1997-04-30 1999-03-09 Schneider Usa Inc Drug-releasing coatings for medical devices
DE19724230C1 (de) 1997-04-30 1998-11-26 Schering Ag Radioaktiv beschichtete Stents, Verfahren zu ihrer Herstellung und ihre Verwendung zur Restenoseprophylaxe
US5980554A (en) 1997-05-05 1999-11-09 Micro Therapeutics, Inc. Wire frame partial flow obstruction for aneurysm treatment
US6344055B1 (en) 1997-05-14 2002-02-05 Novo Rps Ulc Method for production of an expandable stent
US6025036A (en) 1997-05-28 2000-02-15 The United States Of America As Represented By The Secretary Of The Navy Method of producing a film coating by matrix assisted pulsed laser deposition
GB2325934A (en) 1997-06-03 1998-12-09 Polybiomed Ltd Treating metal surfaces to enhance bio-compatibility and/or physical characteristics
US6203536B1 (en) 1997-06-17 2001-03-20 Medtronic, Inc. Medical device for delivering a therapeutic substance and method therefor
US5749809A (en) 1997-06-20 1998-05-12 Lin; Ting Fung Stepping and swinging exerciser
US6500174B1 (en) 1997-07-08 2002-12-31 Atrionix, Inc. Circumferential ablation device assembly and methods of use and manufacture providing an ablative circumferential band along an expandable member
US20020169493A1 (en) 1997-07-10 2002-11-14 Widenhouse Christopher W. Anti-thrombogenic coatings for biomedical devices
US5817046A (en) 1997-07-14 1998-10-06 Delcath Systems, Inc. Apparatus and method for isolated pelvic perfusion
FR2766092B1 (fr) 1997-07-16 1999-10-08 Centre Nat Rech Scient Dispositif implantable recouvert d'un polymere capable de liberer des substances biologiquement actives
DE19731021A1 (de) 1997-07-18 1999-01-21 Meyer Joerg In vivo abbaubares metallisches Implantat
US5972192A (en) 1997-07-23 1999-10-26 Advanced Micro Devices, Inc. Pulse electroplating copper or copper alloys
US6174330B1 (en) * 1997-08-01 2001-01-16 Schneider (Usa) Inc Bioabsorbable marker having radiopaque constituents
US5980564A (en) 1997-08-01 1999-11-09 Schneider (Usa) Inc. Bioabsorbable implantable endoprosthesis with reservoir
US6245103B1 (en) 1997-08-01 2001-06-12 Schneider (Usa) Inc Bioabsorbable self-expanding stent
US5899935A (en) 1997-08-04 1999-05-04 Schneider (Usa) Inc. Balloon expandable braided stent with restraint
DE19734972A1 (de) 1997-08-13 1999-02-18 Cerdec Ag Goldhaltige nanoporöse Aluminiumoxid-Membranen, Verfahren zu deren Herstellung und deren Verwendung
US6316522B1 (en) 1997-08-18 2001-11-13 Scimed Life Systems, Inc. Bioresorbable hydrogel compositions for implantable prostheses
US5854382A (en) 1997-08-18 1998-12-29 Meadox Medicals, Inc. Bioresorbable compositions for implantable prostheses
US6143370A (en) 1997-08-27 2000-11-07 Northeastern University Process for producing polymer coatings with various porosities and surface areas
US6342507B1 (en) 1997-09-05 2002-01-29 Isotechnika, Inc. Deuterated rapamycin compounds, method and uses thereof
US6884429B2 (en) 1997-09-05 2005-04-26 Isotechnika International Inc. Medical devices incorporating deuterated rapamycin for controlled delivery thereof
US5972027A (en) 1997-09-30 1999-10-26 Scimed Life Systems, Inc Porous stent drug delivery system
DE19746735C2 (de) 1997-10-13 2003-11-06 Simag Gmbh Systeme Und Instr F NMR-Bildgebungsverfahren zur Darstellung, Positionsbestimmung oder funktionellen Kontrolle einer in ein Untersuchungsobjekt eingeführten Vorrichtung und Vorrichtung zur Verwendung in einem derartigen Verfahren
CA2218983C (en) 1997-10-21 2001-05-08 Mag R&D, Inc. Cathodic protective coating on magnesium or its alloys and method of producing the same
US6273908B1 (en) 1997-10-24 2001-08-14 Robert Ndondo-Lay Stents
US6309414B1 (en) 1997-11-04 2001-10-30 Sorin Biomedica Cardio S.P.A. Angioplasty stents
WO1999023977A1 (en) 1997-11-07 1999-05-20 Expandable Grafts Partnership Intravascular stent and method for manufacturing an intravascular stent
EP1702914B1 (en) 1997-11-07 2011-04-06 Rutgers, The State University Radio-opaque polymeric biomaterials
NO311781B1 (no) * 1997-11-13 2002-01-28 Medinol Ltd Flerlags-stenter av metall
US5957975A (en) 1997-12-15 1999-09-28 The Cleveland Clinic Foundation Stent having a programmed pattern of in vivo degradation
US5976169A (en) 1997-12-16 1999-11-02 Cardiovasc, Inc. Stent with silver coating and method
US6212434B1 (en) 1998-07-22 2001-04-03 Cardiac Pacemakers, Inc. Single pass lead system
US6626939B1 (en) 1997-12-18 2003-09-30 Boston Scientific Scimed, Inc. Stent-graft with bioabsorbable structural support
US6140740A (en) 1997-12-30 2000-10-31 Remon Medical Technologies, Ltd. Piezoelectric transducer
US6486588B2 (en) 1997-12-30 2002-11-26 Remon Medical Technologies Ltd Acoustic biosensor for monitoring physiological conditions in a body implantation site
US6120660A (en) 1998-02-11 2000-09-19 Silicon Genesis Corporation Removable liner design for plasma immersion ion implantation
CA2316945A1 (en) 1998-02-23 1999-08-26 Mnemoscience Gmbh Shape memory polymers
US6139585A (en) 1998-03-11 2000-10-31 Depuy Orthopaedics, Inc. Bioactive ceramic coating and method
DE19811033C1 (de) 1998-03-13 1999-08-05 Aesculap Ag & Co Kg Chirurgisches Instrument und Verfahren zu dessen Herstellung
WO1999047253A1 (en) 1998-03-19 1999-09-23 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Fabrication of multilayer-coated particles and hollow shells via electrostatic self-assembly of nanocomposite multilayers on decomposable colloidal templates
EP0972563A1 (en) 1998-07-15 2000-01-19 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Fabrication of multilayer-coated particles and hollow shells via electrostatic self-assembly of nanocomposite multilayers on decomposable colloidal templates
US7547445B2 (en) 1998-03-19 2009-06-16 Surmodics, Inc. Crosslinkable macromers
US6241762B1 (en) 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US20040254635A1 (en) 1998-03-30 2004-12-16 Shanley John F. Expandable medical device for delivery of beneficial agent
US7208011B2 (en) 2001-08-20 2007-04-24 Conor Medsystems, Inc. Implantable medical device with drug filled holes
US5980566A (en) 1998-04-11 1999-11-09 Alt; Eckhard Vascular and endoluminal stents with iridium oxide coating
US7713297B2 (en) 1998-04-11 2010-05-11 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
US6364856B1 (en) 1998-04-14 2002-04-02 Boston Scientific Corporation Medical device with sponge coating for controlled drug release
US6206916B1 (en) 1998-04-15 2001-03-27 Joseph G. Furst Coated intraluminal graft
US6436133B1 (en) 1998-04-15 2002-08-20 Joseph G. Furst Expandable graft
US20020099438A1 (en) 1998-04-15 2002-07-25 Furst Joseph G. Irradiated stent coating
US6264687B1 (en) 1998-04-20 2001-07-24 Cordis Corporation Multi-laminate stent having superelastic articulated sections
US6206914B1 (en) 1998-04-30 2001-03-27 Medtronic, Inc. Implantable system with drug-eluting cells for on-demand local drug delivery
US6270831B2 (en) 1998-04-30 2001-08-07 Medquest Products, Inc. Method and apparatus for providing a conductive, amorphous non-stick coating
WO1999056663A2 (en) 1998-05-05 1999-11-11 Scimed Life Systems, Inc. Stent with smooth ends
US6206283B1 (en) 1998-12-23 2001-03-27 At&T Corp. Method and apparatus for transferring money via a telephone call
US6280411B1 (en) 1998-05-18 2001-08-28 Scimed Life Systems, Inc. Localized delivery of drug agents
US8177743B2 (en) 1998-05-18 2012-05-15 Boston Scientific Scimed, Inc. Localized delivery of drug agents
US6086773A (en) 1998-05-22 2000-07-11 Bmc Industries, Inc. Method and apparatus for etching-manufacture of cylindrical elements
DE19856983A1 (de) 1998-06-25 1999-12-30 Biotronik Mess & Therapieg Implantierbare, bioresorbierbare Gefäßwandstütze, insbesondere Koronarstent
DE59913189D1 (de) 1998-06-25 2006-05-04 Biotronik Ag Implantierbare, bioresorbierbare Gefässwandstütze, insbesondere Koronarstent
US6153252A (en) 1998-06-30 2000-11-28 Ethicon, Inc. Process for coating stents
US6652581B1 (en) 1998-07-07 2003-11-25 Boston Scientific Scimed, Inc. Medical device with porous surface for controlled drug release and method of making the same
US6096175A (en) 1998-07-17 2000-08-01 Micro Therapeutics, Inc. Thin film stent
US8070796B2 (en) 1998-07-27 2011-12-06 Icon Interventional Systems, Inc. Thrombosis inhibiting graft
US20040088041A1 (en) 1999-07-20 2004-05-06 Stanford Ulf Harry Expandable stent with array of relief cuts
US20020038146A1 (en) 1998-07-29 2002-03-28 Ulf Harry Expandable stent with relief cuts for carrying medicines and other materials
US20010032011A1 (en) 1999-07-20 2001-10-18 Stanford Ulf Harry Expandable stent with array of relief cuts
EP1105169A1 (en) 1998-08-20 2001-06-13 Cook Incorporated Coated implantable medical device
US7235096B1 (en) 1998-08-25 2007-06-26 Tricardia, Llc Implantable device for promoting repair of a body lumen
US6335029B1 (en) * 1998-08-28 2002-01-01 Scimed Life Systems, Inc. Polymeric coatings for controlled delivery of active agents
US6755856B2 (en) 1998-09-05 2004-06-29 Abbott Laboratories Vascular Enterprises Limited Methods and apparatus for stenting comprising enhanced embolic protection, coupled with improved protection against restenosis and thrombus formation
US6206915B1 (en) 1998-09-29 2001-03-27 Medtronic Ave, Inc. Drug storing and metering stent
US6358276B1 (en) 1998-09-30 2002-03-19 Impra, Inc. Fluid containing endoluminal stent
US6217607B1 (en) 1998-10-20 2001-04-17 Inflow Dynamics Inc. Premounted stent delivery system for small vessels
DE19855421C2 (de) 1998-11-02 2001-09-20 Alcove Surfaces Gmbh Implantat
US6348960B1 (en) 1998-11-06 2002-02-19 Kimotot Co., Ltd. Front scattering film
US6214042B1 (en) 1998-11-10 2001-04-10 Precision Vascular Systems, Inc. Micro-machined stent for vessels, body ducts and the like
US6984404B1 (en) * 1998-11-18 2006-01-10 University Of Florida Research Foundation, Inc. Methods for preparing coated drug particles and pharmaceutical formulations thereof
US6063101A (en) 1998-11-20 2000-05-16 Precision Vascular Systems, Inc. Stent apparatus and method
JP3566211B2 (ja) * 1998-11-26 2004-09-15 インフィネオン テクノロジース アクチエンゲゼルシャフト Ｓｂｔを析出するための前駆体組合せ物
US20060178727A1 (en) 1998-12-03 2006-08-10 Jacob Richter Hybrid amorphous metal alloy stent
SE9804536D0 (sv) 1998-12-23 1998-12-23 A & Science Invest Ab Biological implant and method for production thereof
US6517571B1 (en) 1999-01-22 2003-02-11 Gore Enterprise Holdings, Inc. Vascular graft with improved flow surfaces
US6955661B1 (en) 1999-01-25 2005-10-18 Atrium Medical Corporation Expandable fluoropolymer device for delivery of therapeutic agents and method of making
US6264595B1 (en) 1999-02-04 2001-07-24 Mobeta, Inc. Radioactive transition metal stents
RU2218242C2 (ru) 1999-02-11 2003-12-10 Физический институт им. П.Н. Лебедева РАН Способ изготовления медицинских имплантатов из биосовместимых материалов
WO2000048530A1 (en) 1999-02-16 2000-08-24 Talison Research, Inc. Multilayer and multifunction vascular graft
DE19948783C2 (de) 1999-02-18 2001-06-13 Alcove Surfaces Gmbh Implantat
US6162238A (en) 1999-02-24 2000-12-19 Aaron V. Kaplan Apparatus and methods for control of body lumens
US6296604B1 (en) 1999-03-17 2001-10-02 Stereotaxis, Inc. Methods of and compositions for treating vascular defects
US6214037B1 (en) 1999-03-18 2001-04-10 Fossa Industries, Llc Radially expanding stent
US6364903B2 (en) 1999-03-19 2002-04-02 Meadox Medicals, Inc. Polymer coated stent
US6170488B1 (en) 1999-03-24 2001-01-09 The B. F. Goodrich Company Acoustic-based remotely interrogated diagnostic implant device and system
US6558422B1 (en) 1999-03-26 2003-05-06 University Of Washington Structures having coated indentations
US6312457B1 (en) 1999-04-01 2001-11-06 Boston Scientific Corporation Intraluminal lining
US6425855B2 (en) 1999-04-06 2002-07-30 Cordis Corporation Method for making a multi-laminate stent having superelastic articulated sections
US6325825B1 (en) 1999-04-08 2001-12-04 Cordis Corporation Stent with variable wall thickness
US6366808B1 (en) 2000-03-13 2002-04-02 Edward A. Schroeppel Implantable device and method for the electrical treatment of cancer
US6258117B1 (en) 1999-04-15 2001-07-10 Mayo Foundation For Medical Education And Research Multi-section stent
US6368658B1 (en) 1999-04-19 2002-04-09 Scimed Life Systems, Inc. Coating medical devices using air suspension
US6607598B2 (en) 1999-04-19 2003-08-19 Scimed Life Systems, Inc. Device for protecting medical devices during a coating process
US6192271B1 (en) 1999-04-20 2001-02-20 Michael Hayman Radiotherapy stent
US6287335B1 (en) 1999-04-26 2001-09-11 William J. Drasler Intravascular folded tubular endoprosthesis
US6461731B1 (en) 1999-05-03 2002-10-08 Guardian Industries Corp. Solar management coating system including protective DLC
US6201991B1 (en) 1999-05-07 2001-03-13 Heart Care Associates, Llc Method of prevention and treatment of atherosclerosis and article of manufacture therefor
US6726712B1 (en) 1999-05-14 2004-04-27 Boston Scientific Scimed Prosthesis deployment device with translucent distal end
US6610035B2 (en) 1999-05-21 2003-08-26 Scimed Life Systems, Inc. Hydrophilic lubricity coating for medical devices comprising a hybrid top coat
WO2000072894A1 (fr) 1999-05-31 2000-12-07 Sumitomo Electric Industries, Ltd. Prothèse de vaisseau sanguin
US6368346B1 (en) 1999-06-03 2002-04-09 American Medical Systems, Inc. Bioresorbable stent
US6406745B1 (en) 1999-06-07 2002-06-18 Nanosphere, Inc. Methods for coating particles and particles produced thereby
DE60009493T2 (de) 1999-06-24 2005-03-17 Abbott Vascular Devices Ltd. Mittels eines ballons expandierbarer stent
US6139913A (en) 1999-06-29 2000-10-31 National Center For Manufacturing Sciences Kinetic spray coating method and apparatus
US6258121B1 (en) 1999-07-02 2001-07-10 Scimed Life Systems, Inc. Stent coating
NO312106B1 (no) 1999-07-02 2002-03-18 Norsk Hydro As Fremgangsmåte for å forbedre korrosjonsmotstanden for magnesium-aluminium-silisiumlegeringer og magnesiumlegering medforbedret korrosjonsmotstand
US6409754B1 (en) 1999-07-02 2002-06-25 Scimed Life Systems, Inc. Flexible segmented stent
US20040073155A1 (en) * 2000-01-14 2004-04-15 Broncus Technologies, Inc. Methods and devices for maintaining patency of surgically created channels in tissue
IT1307263B1 (it) 1999-08-05 2001-10-30 Sorin Biomedica Cardio Spa Stent per angioplastica con azione antagonista della restenosi,relativo corredo e componenti.
US6458162B1 (en) 1999-08-13 2002-10-01 Vita Special Purpose Corporation Composite shaped bodies and methods for their production and use
US6869701B1 (en) 1999-08-16 2005-03-22 Carolyn Aita Self-repairing ceramic coatings
US6503556B2 (en) * 2000-12-28 2003-01-07 Advanced Cardiovascular Systems, Inc. Methods of forming a coating for a prosthesis
US6790228B2 (en) 1999-12-23 2004-09-14 Advanced Cardiovascular Systems, Inc. Coating for implantable devices and a method of forming the same
US6287628B1 (en) 1999-09-03 2001-09-11 Advanced Cardiovascular Systems, Inc. Porous prosthesis and a method of depositing substances into the pores
DE19950386A1 (de) 1999-10-19 2001-05-10 Miladin Lazarov Biokompatibler Gegenstand
DE19951477A1 (de) 1999-10-26 2001-05-03 Biotronik Mess & Therapieg Stent
US8808272B2 (en) 1999-10-28 2014-08-19 Boston Scientific Scimed, Inc. Biocompatible medical devices
US6521284B1 (en) 1999-11-03 2003-02-18 Scimed Life Systems, Inc. Process for impregnating a porous material with a cross-linkable composition
US6733513B2 (en) 1999-11-04 2004-05-11 Advanced Bioprosthetic Surfaces, Ltd. Balloon catheter having metal balloon and method of making same
US7226475B2 (en) 1999-11-09 2007-06-05 Boston Scientific Scimed, Inc. Stent with variable properties
US6337076B1 (en) * 1999-11-17 2002-01-08 Sg Licensing Corporation Method and composition for the treatment of scars
AU770395B2 (en) 1999-11-17 2004-02-19 Boston Scientific Limited Microfabricated devices for the delivery of molecules into a carrier fluid
US6458153B1 (en) 1999-12-31 2002-10-01 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US6379383B1 (en) 1999-11-19 2002-04-30 Advanced Bio Prosthetic Surfaces, Ltd. Endoluminal device exhibiting improved endothelialization and method of manufacture thereof
US6849085B2 (en) 1999-11-19 2005-02-01 Advanced Bio Prosthetic Surfaces, Ltd. Self-supporting laminated films, structural materials and medical devices manufactured therefrom and method of making same
US7235092B2 (en) 1999-11-19 2007-06-26 Advanced Bio Prosthetic Surfaces, Ltd. Guidewires and thin film catheter-sheaths and method of making same
US7195641B2 (en) 1999-11-19 2007-03-27 Advanced Bio Prosthetic Surfaces, Ltd. Valvular prostheses having metal or pseudometallic construction and methods of manufacture
US6537310B1 (en) 1999-11-19 2003-03-25 Advanced Bio Prosthetic Surfaces, Ltd. Endoluminal implantable devices and method of making same
US7300457B2 (en) 1999-11-19 2007-11-27 Advanced Bio Prosthetic Surfaces, Ltd. Self-supporting metallic implantable grafts, compliant implantable medical devices and methods of making same
US6277078B1 (en) 1999-11-19 2001-08-21 Remon Medical Technologies, Ltd. System and method for monitoring a parameter associated with the performance of a heart
US7335426B2 (en) 1999-11-19 2008-02-26 Advanced Bio Prosthetic Surfaces, Ltd. High strength vacuum deposited nitinol alloy films and method of making same
US6936066B2 (en) 1999-11-19 2005-08-30 Advanced Bio Prosthetic Surfaces, Ltd. Complaint implantable medical devices and methods of making same
ES2258482T3 (es) 1999-12-03 2006-09-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Monomeros electropolimerizables y revestimientos polimericos de dispositivos implantables.
US20060013850A1 (en) * 1999-12-03 2006-01-19 Domb Abraham J Electropolymerizable monomers and polymeric coatings on implantable devices prepared therefrom
US6602287B1 (en) 1999-12-08 2003-08-05 Advanced Cardiovascular Systems, Inc. Stent with anti-thrombogenic coating
US6251136B1 (en) 1999-12-08 2001-06-26 Advanced Cardiovascular Systems, Inc. Method of layering a three-coated stent using pharmacological and polymeric agents
US6613432B2 (en) 1999-12-22 2003-09-02 Biosurface Engineering Technologies, Inc. Plasma-deposited coatings, devices and methods
US6338739B1 (en) 1999-12-22 2002-01-15 Ethicon, Inc. Biodegradable stent
US6908624B2 (en) 1999-12-23 2005-06-21 Advanced Cardiovascular Systems, Inc. Coating for implantable devices and a method of forming the same
AU2623201A (en) 1999-12-30 2001-07-16 Kam W Leong Controlled delivery of therapeutic agents by insertable medical devices
US6471721B1 (en) 1999-12-30 2002-10-29 Advanced Cardiovascular Systems, Inc. Vascular stent having increased radiopacity and method for making same
US6451177B1 (en) * 2000-01-21 2002-09-17 Applied Materials, Inc. Vault shaped target and magnetron operable in two sputtering modes
EP1264001A1 (en) * 2000-01-25 2002-12-11 Boston Scientific Limited Manufacturing medical devices by vapor deposition
US6312463B1 (en) 2000-02-01 2001-11-06 Endotex Interventional Systems, Inc. Micro-porous mesh stent with hybrid structure
US6375826B1 (en) 2000-02-14 2002-04-23 Advanced Cardiovascular Systems, Inc. Electro-polishing fixture and electrolyte solution for polishing stents and method
AU780539B2 (en) 2000-02-25 2005-03-24 Cordis Corporation Use of cladribine on a stent to prevent restenosis
EP1132058A1 (en) * 2000-03-06 2001-09-12 Advanced Laser Applications Holding S.A. Intravascular prothesis
US6379382B1 (en) 2000-03-13 2002-04-30 Jun Yang Stent having cover with drug delivery capability
US6290722B1 (en) 2000-03-13 2001-09-18 Endovascular Technologies, Inc. Tacky attachment method of covered materials on stents
US7037332B2 (en) 2000-03-15 2006-05-02 Orbus Medical Technologies, Inc. Medical device with coating that promotes endothelial cell adherence
US20160287708A9 (en) 2000-03-15 2016-10-06 Orbusneich Medical, Inc. Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device
US6695865B2 (en) 2000-03-20 2004-02-24 Advanced Bio Prosthetic Surfaces, Ltd. Embolic protection device
US6315708B1 (en) * 2000-03-31 2001-11-13 Cordis Corporation Stent with self-expanding end sections
US6527801B1 (en) 2000-04-13 2003-03-04 Advanced Cardiovascular Systems, Inc. Biodegradable drug delivery material for stent
US6719987B2 (en) 2000-04-17 2004-04-13 Nucryst Pharmaceuticals Corp. Antimicrobial bioabsorbable materials
US6327504B1 (en) 2000-05-10 2001-12-04 Thoratec Corporation Transcutaneous energy transfer with circuitry arranged to avoid overheating
US8845713B2 (en) 2000-05-12 2014-09-30 Advanced Bio Prosthetic Surfaces, Ltd., A Wholly Owned Subsidiary Of Palmaz Scientific, Inc. Self-supporting laminated films, structural materials and medical devices manufactured therefrom and methods of making same
KR100360364B1 (ko) 2000-05-22 2002-11-13 주식회사 정성메디칼 관상동맥 설치용 금속 스텐트
US6673385B1 (en) * 2000-05-31 2004-01-06 Advanced Cardiovascular Systems, Inc. Methods for polymeric coatings stents
US6395326B1 (en) * 2000-05-31 2002-05-28 Advanced Cardiovascular Systems, Inc. Apparatus and method for depositing a coating onto a surface of a prosthesis
US20040211362A1 (en) 2000-05-31 2004-10-28 Daniel Castro System for coating a stent
JP4545888B2 (ja) 2000-06-08 2010-09-15 株式会社泉精器製作所 固液分離装置
WO2001095834A1 (en) * 2000-06-13 2001-12-20 Scimed Life Systems, Inc. Disintegrating stent and method of making same
US6418337B1 (en) 2000-06-15 2002-07-09 Autolitt Inc. MRI guided hyperthermia surgery
JP4656697B2 (ja) 2000-06-16 2011-03-23 キヤノンアネルバ株式会社 高周波スパッタリング装置
US6585765B1 (en) 2000-06-29 2003-07-01 Advanced Cardiovascular Systems, Inc. Implantable device having substances impregnated therein and a method of impregnating the same
DE10032220A1 (de) 2000-07-03 2002-01-24 Sanatis Gmbh Magnesium-ammonium-phosphat-Zemente, deren Herstellung und Verwendung
US20030018380A1 (en) 2000-07-07 2003-01-23 Craig Charles H. Platinum enhanced alloy and intravascular or implantable medical devices manufactured therefrom
US20020144757A1 (en) 2000-07-07 2002-10-10 Craig Charles Horace Stainless steel alloy with improved radiopaque characteristics
US20030077200A1 (en) 2000-07-07 2003-04-24 Craig Charles H. Enhanced radiopaque alloy stent
AU2001273276A1 (en) * 2000-07-10 2002-01-21 Epion Corporation Improving effectiveness of medical stents by gcib
US6709451B1 (en) 2000-07-14 2004-03-23 Norman Noble, Inc. Channeled vascular stent apparatus and method
US6629992B2 (en) 2000-08-04 2003-10-07 Advanced Cardiovascular Systems, Inc. Sheath for self-expanding stent
US6451373B1 (en) 2000-08-04 2002-09-17 Advanced Cardiovascular Systems, Inc. Method of forming a therapeutic coating onto a surface of an implantable prosthesis
KR100902625B1 (ko) 2000-08-15 2009-06-15 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 마이크로입자
US6390967B1 (en) 2000-09-14 2002-05-21 Xoft Microtube, Inc. Radiation for inhibiting hyperplasia after intravascular intervention
US7101391B2 (en) 2000-09-18 2006-09-05 Inflow Dynamics Inc. Primarily niobium stent
US6478815B1 (en) 2000-09-18 2002-11-12 Inflow Dynamics Inc. Vascular and endoluminal stents
US7402173B2 (en) 2000-09-18 2008-07-22 Boston Scientific Scimed, Inc. Metal stent with surface layer of noble metal oxide and method of fabrication
US6953560B1 (en) 2000-09-28 2005-10-11 Advanced Cardiovascular Systems, Inc. Barriers for polymer-coated implantable medical devices and methods for making the same
US6716444B1 (en) 2000-09-28 2004-04-06 Advanced Cardiovascular Systems, Inc. Barriers for polymer-coated implantable medical devices and methods for making the same
US6254632B1 (en) 2000-09-28 2001-07-03 Advanced Cardiovascular Systems, Inc. Implantable medical device having protruding surface structures for drug delivery and cover attachment
US6805898B1 (en) 2000-09-28 2004-10-19 Advanced Cardiovascular Systems, Inc. Surface features of an implantable medical device
KR200227881Y1 (ko) 2000-09-29 2001-06-15 주식회사이오니아테크놀로지 치과치료용 영상저장장치
US20020051730A1 (en) 2000-09-29 2002-05-02 Stanko Bodnar Coated medical devices and sterilization thereof
US7261735B2 (en) 2001-05-07 2007-08-28 Cordis Corporation Local drug delivery devices and methods for maintaining the drug coatings thereon
US6628989B1 (en) 2000-10-16 2003-09-30 Remon Medical Technologies, Ltd. Acoustic switch and apparatus and methods for using acoustic switches within a body
US6506437B1 (en) 2000-10-17 2003-01-14 Advanced Cardiovascular Systems, Inc. Methods of coating an implantable device having depots formed in a surface thereof
US6979347B1 (en) 2000-10-23 2005-12-27 Advanced Cardiovascular Systems, Inc. Implantable drug delivery prosthesis
US6558733B1 (en) 2000-10-26 2003-05-06 Advanced Cardiovascular Systems, Inc. Method for etching a micropatterned microdepot prosthesis
US6663664B1 (en) 2000-10-26 2003-12-16 Advanced Cardiovascular Systems, Inc. Self-expanding stent with time variable radial force
US6758859B1 (en) 2000-10-30 2004-07-06 Kenny L. Dang Increased drug-loading and reduced stress drug delivery device
EP1330273B1 (en) 2000-10-31 2007-07-25 Cook Incorporated Coated implantable medical device
US6770086B1 (en) 2000-11-02 2004-08-03 Scimed Life Systems, Inc. Stent covering formed of porous polytetraflouroethylene
DE10055686A1 (de) 2000-11-03 2002-05-08 Biotronik Mess & Therapieg Vorrichtung zur Beeinflussung von Zellproliferationsmechanismen in Gefäßen des menschlichen oder tierischen Körpers
DE60114453T2 (de) 2000-11-27 2006-07-13 National University Of Singapore Verfahren und vorrichtung zur herstellung eines dreidimensionalen metallteils unter verwendung von hochtemperatur-direktlaserschmelzen
US6517888B1 (en) 2000-11-28 2003-02-11 Scimed Life Systems, Inc. Method for manufacturing a medical device having a coated portion by laser ablation
WO2002043799A1 (fr) 2000-11-30 2002-06-06 Kabushikikaisha Igaki Iryo Sekkei Endoprothese vasculaire et materiau d'endoprothese vasculaire
US7192445B2 (en) 2000-12-06 2007-03-20 Astra Tech Ab Medical prosthetic devices and implants having improved biocompatibility
US6545097B2 (en) 2000-12-12 2003-04-08 Scimed Life Systems, Inc. Drug delivery compositions and medical devices containing block copolymer
WO2002047581A1 (en) 2000-12-15 2002-06-20 Badari Narayan Nagarada Gadde Stent with drug-delivery system
ATE310470T1 (de) 2000-12-15 2005-12-15 Angiomed Ag Stent mit herzklappe
DE10064596A1 (de) 2000-12-18 2002-06-20 Biotronik Mess & Therapieg Verfahren zum Anbringen eines Markerelements an einem Implantat sowie mit einem Markerelement versehenes Implantat
US20040030377A1 (en) 2001-10-19 2004-02-12 Alexander Dubson Medicated polymer-coated stent assembly
US7244272B2 (en) 2000-12-19 2007-07-17 Nicast Ltd. Vascular prosthesis and method for production thereof
US20020082679A1 (en) 2000-12-22 2002-06-27 Avantec Vascular Corporation Delivery or therapeutic capable agents
US20030033007A1 (en) 2000-12-22 2003-02-13 Avantec Vascular Corporation Methods and devices for delivery of therapeutic capable agents with variable release profile
US7077859B2 (en) 2000-12-22 2006-07-18 Avantec Vascular Corporation Apparatus and methods for variably controlled substance delivery from implanted prostheses
US6471980B2 (en) 2000-12-22 2002-10-29 Avantec Vascular Corporation Intravascular delivery of mycophenolic acid
US6398806B1 (en) 2000-12-26 2002-06-04 Scimed Life Systems, Inc. Monolayer modification to gold coated stents to reduce adsorption of protein
US6913617B1 (en) 2000-12-27 2005-07-05 Advanced Cardiovascular Systems, Inc. Method for creating a textured surface on an implantable medical device
US6663662B2 (en) 2000-12-28 2003-12-16 Advanced Cardiovascular Systems, Inc. Diffusion barrier layer for implantable devices
US6641607B1 (en) 2000-12-29 2003-11-04 Advanced Cardiovascular Systems, Inc. Double tube stent
US6635082B1 (en) 2000-12-29 2003-10-21 Advanced Cardiovascular Systems Inc. Radiopaque stent
WO2002053193A2 (en) 2001-01-02 2002-07-11 The Charles Stark Draper Laboratory, Inc. Tissue engineering of three-dimensional vascularized using microfabricated polymer assembly technology
US20020087123A1 (en) 2001-01-02 2002-07-04 Hossainy Syed F.A. Adhesion of heparin-containing coatings to blood-contacting surfaces of medical devices
US6544582B1 (en) 2001-01-05 2003-04-08 Advanced Cardiovascular Systems, Inc. Method and apparatus for coating an implantable device
ATE306953T1 (de) 2001-01-05 2005-11-15 Jacqueline Yvonne Hausdorf Durch korrosion abbaubare metallische medizinische implantate
GB0100760D0 (en) 2001-01-11 2001-02-21 Biocompatibles Ltd Drug delivery from stents
US20010044650A1 (en) 2001-01-12 2001-11-22 Simso Eric J. Stent for in-stent restenosis
US20020092583A1 (en) 2001-01-16 2002-07-18 Pelton Alan R. Medical devices, particularly stents, and methods for their manufacture
US6752829B2 (en) 2001-01-30 2004-06-22 Scimed Life Systems, Inc. Stent with channel(s) for containing and delivering a biologically active material and method for manufacturing the same
US20040220660A1 (en) 2001-02-05 2004-11-04 Shanley John F. Bioresorbable stent with beneficial agent reservoirs
US6767360B1 (en) 2001-02-08 2004-07-27 Inflow Dynamics Inc. Vascular stent with composite structure for magnetic reasonance imaging capabilities
KR100994543B1 (ko) 2001-02-16 2010-11-16 아스텔라스세이야쿠 가부시키가이샤 Ｆｋ506을 포함하는 이식편
US6998060B2 (en) 2001-03-01 2006-02-14 Cordis Corporation Flexible stent and method of manufacture
ATE322918T1 (de) 2001-03-02 2006-04-15 Univ Laval Plasma oberflächen-pfropfprozess zur thrombogenitäts-reduzierung
US7238199B2 (en) 2001-03-06 2007-07-03 The Board Of Regents Of The University Of Texas System Method and apparatus for stent deployment with enhanced delivery of bioactive agents
US20020133224A1 (en) 2001-03-13 2002-09-19 Clara Bajgar Drug eluting encapsulated stent
CN1531413A (zh) 2001-03-20 2004-09-22 GMPǿ�ı�����˾ 轨道展开装置
US6913765B2 (en) 2001-03-21 2005-07-05 Scimed Life Systems, Inc. Controlling resorption of bioresorbable medical implant material
DE20220502U1 (de) 2001-03-23 2003-10-02 Alcove Surfaces Gmbh Implantat
US20020138136A1 (en) 2001-03-23 2002-09-26 Scimed Life Systems, Inc. Medical device having radio-opacification and barrier layers
US6613077B2 (en) 2001-03-27 2003-09-02 Scimed Life Systems, Inc. Stent with controlled expansion
US6780424B2 (en) 2001-03-30 2004-08-24 Charles David Claude Controlled morphologies in polymer drug for release of drugs from polymer films
US6673105B1 (en) * 2001-04-02 2004-01-06 Advanced Cardiovascular Systems, Inc. Metal prosthesis coated with expandable ePTFE
US6764505B1 (en) 2001-04-12 2004-07-20 Advanced Cardiovascular Systems, Inc. Variable surface area stent
US7056339B2 (en) * 2001-04-20 2006-06-06 The Board Of Trustees Of The Leland Stanford Junior University Drug delivery platform
US7048939B2 (en) 2001-04-20 2006-05-23 The Board Of Trustees Of The Leland Stanford Junior University Methods for the inhibition of neointima formation
WO2002085385A2 (en) 2001-04-23 2002-10-31 Nucryst Pharmaceuticals Corp. Medicament containing a metal such as silver, gold, platinum or palladium as an antimicrobial agent and their use in the treatment of diseases of the mucosa
US6712845B2 (en) 2001-04-24 2004-03-30 Advanced Cardiovascular Systems, Inc. Coating for a stent and a method of forming the same
US7232460B2 (en) 2001-04-25 2007-06-19 Xillus, Inc. Nanodevices, microdevices and sensors on in-vivo structures and method for the same
US6887857B2 (en) 2001-04-27 2005-05-03 Scimed Life Systems, Inc. Microparticle protection of therapeutic agents
US6660034B1 (en) 2001-04-30 2003-12-09 Advanced Cardiovascular Systems, Inc. Stent for increasing blood flow to ischemic tissues and a method of using the same
US6613083B2 (en) 2001-05-02 2003-09-02 Eckhard Alt Stent device and method
EP1393601B1 (en) 2001-05-11 2010-09-29 Exogenesis Corporation Method for improving the effectiveness of medical devices by adhering drugs to the surface thereof
WO2002096389A1 (en) 2001-05-30 2002-12-05 Microchips, Inc. Conformal coated microchip reservoir devices
US6827966B2 (en) 2001-05-30 2004-12-07 Novartis Ag Diffusion-controllable coatings on medical device
US7862495B2 (en) 2001-05-31 2011-01-04 Advanced Cardiovascular Systems, Inc. Radiation or drug delivery source with activity gradient to minimize edge effects
US6712844B2 (en) 2001-06-06 2004-03-30 Advanced Cardiovascular Systems, Inc. MRI compatible stent
CA2450160C (en) 2001-06-11 2011-03-22 Boston Scientific Limited Composite eptfe/textile prosthesis
US7560006B2 (en) 2001-06-11 2009-07-14 Boston Scientific Scimed, Inc. Pressure lamination method for forming composite ePTFE/textile and ePTFE/stent/textile prostheses
US7201940B1 (en) 2001-06-12 2007-04-10 Advanced Cardiovascular Systems, Inc. Method and apparatus for thermal spray processing of medical devices
US6527938B2 (en) 2001-06-21 2003-03-04 Syntheon, Llc Method for microporous surface modification of implantable metallic medical articles
US6844028B2 (en) 2001-06-26 2005-01-18 Accelr8 Technology Corporation Functional surface coating
US20030003127A1 (en) * 2001-06-27 2003-01-02 Ethicon, Inc. Porous ceramic/porous polymer layered scaffolds for the repair and regeneration of tissue
US7727221B2 (en) 2001-06-27 2010-06-01 Cardiac Pacemakers Inc. Method and device for electrochemical formation of therapeutic species in vivo
US6585755B2 (en) * 2001-06-29 2003-07-01 Advanced Cardiovascular Polymeric stent suitable for imaging by MRI and fluoroscopy
US6656216B1 (en) * 2001-06-29 2003-12-02 Advanced Cardiovascular Systems, Inc. Composite stent with regioselective material
US6676987B2 (en) 2001-07-02 2004-01-13 Scimed Life Systems, Inc. Coating a medical appliance with a bubble jet printing head
US20030050687A1 (en) 2001-07-03 2003-03-13 Schwade Nathan D. Biocompatible stents and method of deployment
EP1273314A1 (en) 2001-07-06 2003-01-08 Terumo Kabushiki Kaisha Stent
DE60120955T3 (de) 2001-07-20 2015-06-25 Cid S.P.A. Stent
US6921390B2 (en) 2001-07-23 2005-07-26 Boston Scientific Scimed, Inc. Long-term indwelling medical devices containing slow-releasing antimicrobial agents and having a surfactant surface
US6979346B1 (en) 2001-08-08 2005-12-27 Advanced Cardiovascular Systems, Inc. System and method for improved stent retention
EP1414374B1 (de) 2001-08-08 2005-10-26 Arno Bücker Magnetresonanzkompatible metallische endoprothese
GB0119652D0 (en) 2001-08-11 2001-10-03 Stanmore Implants Worldwide Surgical implant
US6585997B2 (en) 2001-08-16 2003-07-01 Access Pharmaceuticals, Inc. Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds
US20040249443A1 (en) 2001-08-20 2004-12-09 Shanley John F. Expandable medical device for treating cardiac arrhythmias
US7056338B2 (en) 2003-03-28 2006-06-06 Conor Medsystems, Inc. Therapeutic agent delivery device with controlled therapeutic agent release rates
US6632231B2 (en) 2001-08-23 2003-10-14 Scimed Life Systems, Inc. Segmented balloon catheter blade
GB0121980D0 (en) 2001-09-11 2001-10-31 Cathnet Science Holding As Expandable stent
US6589286B1 (en) 2001-09-12 2003-07-08 Jason Litner Eustachian tube stent
EP1424957A2 (en) 2001-09-14 2004-06-09 Francis J. Martin Microfabricated nanopore device for sustained release of therapeutic agent
US20030158598A1 (en) 2001-09-17 2003-08-21 Control Delivery Systems, Inc. System for sustained-release delivery of anti-inflammatory agents from a coated medical device
IN2014DN10834A (ja) 2001-09-17 2015-09-04 Psivida Inc
US6669980B2 (en) 2001-09-18 2003-12-30 Scimed Life Systems, Inc. Method for spray-coating medical devices
US20030060873A1 (en) 2001-09-19 2003-03-27 Nanomedical Technologies, Inc. Metallic structures incorporating bioactive materials and methods for creating the same
US7776379B2 (en) 2001-09-19 2010-08-17 Medlogics Device Corporation Metallic structures incorporating bioactive materials and methods for creating the same
DE60238422D1 (de) 2001-09-24 2011-01-05 Boston Scient Ltd Optimierte dosierung bei paclitaxelhaltigen stents
US6827737B2 (en) 2001-09-25 2004-12-07 Scimed Life Systems, Inc. EPTFE covering for endovascular prostheses and method of manufacture
US7195640B2 (en) 2001-09-25 2007-03-27 Cordis Corporation Coated medical devices for the treatment of vulnerable plaque
US6753071B1 (en) 2001-09-27 2004-06-22 Advanced Cardiovascular Systems, Inc. Rate-reducing membrane for release of an agent
DE10150995A1 (de) 2001-10-08 2003-04-10 Biotronik Mess & Therapieg Implantat mit proliferationshemmender Substanz
US7157096B2 (en) * 2001-10-12 2007-01-02 Inframat Corporation Coatings, coated articles and methods of manufacture thereof
US6709397B2 (en) 2001-10-16 2004-03-23 Envisioneering, L.L.C. Scanning probe
US20030077310A1 (en) * 2001-10-22 2003-04-24 Chandrashekhar Pathak Stent coatings containing HMG-CoA reductase inhibitors
US7722894B2 (en) 2001-10-22 2010-05-25 Massachusetts Institute Of Technology Biodegradable polymer
US8562664B2 (en) 2001-10-25 2013-10-22 Advanced Cardiovascular Systems, Inc. Manufacture of fine-grained material for use in medical devices
US8740973B2 (en) 2001-10-26 2014-06-03 Icon Medical Corp. Polymer biodegradable medical device
US20030083614A1 (en) 2001-10-30 2003-05-01 Boehringer Ingelheim Pharma Kg Controlled release endoprosthetic device
US20030088307A1 (en) 2001-11-05 2003-05-08 Shulze John E. Potent coatings for stents
US6730282B2 (en) 2001-11-05 2004-05-04 N Vara Technology S.R.L. Sol-gel process for the manufacture of nanocomposite photoluminescent materials
US6764709B2 (en) 2001-11-08 2004-07-20 Scimed Life Systems, Inc. Method for making and measuring a coating on the surface of a medical device using an ultraviolet laser
US6807440B2 (en) 2001-11-09 2004-10-19 Scimed Life Systems, Inc. Ceramic reinforcement members for MRI devices
EP1310242A1 (en) 2001-11-13 2003-05-14 SORIN BIOMEDICA CARDIO S.p.A. Carrier and kit for endoluminal delivery of active principles
US6729336B2 (en) 2001-11-27 2004-05-04 Pearl Technology Holdings, Llc In-stent restenosis detection device
US20030100830A1 (en) 2001-11-27 2003-05-29 Sheng-Ping Zhong Implantable or insertable medical devices visible under magnetic resonance imaging
US7014654B2 (en) 2001-11-30 2006-03-21 Scimed Life Systems, Inc. Stent designed for the delivery of therapeutic substance or other agents
US6752826B2 (en) 2001-12-14 2004-06-22 Thoratec Corporation Layered stent-graft and methods of making the same
US6939374B2 (en) 2001-12-21 2005-09-06 Scimed Life Systems, Inc. Stents, stenting systems, and related methods for agent delivery
DE10163107C1 (de) 2001-12-24 2003-07-10 Univ Hannover Magnesium-Werkstück und Verfahren zur Ausbildung einer korrosionsschützenden Deckschicht eines Magnesium-Werkstücks
US6866805B2 (en) 2001-12-27 2005-03-15 Advanced Cardiovascular Systems, Inc. Hybrid intravascular stent
US6743388B2 (en) 2001-12-31 2004-06-01 Advanced Cardiovascular Systems, Inc. Process of making polymer articles
US20030135265A1 (en) 2002-01-04 2003-07-17 Stinson Jonathan S. Prostheses implantable in enteral vessels
US6506972B1 (en) * 2002-01-22 2003-01-14 Nanoset, Llc Magnetically shielded conductor
US6906256B1 (en) 2002-01-22 2005-06-14 Nanoset, Llc Nanomagnetic shielding assembly
EP1476882A4 (en) 2002-01-22 2007-01-17 Nanoset Llc NANOMAGNETIC SHIELD SUBSTRATE
US6864418B2 (en) 2002-12-18 2005-03-08 Nanoset, Llc Nanomagnetically shielded substrate
US7060089B2 (en) 2002-01-23 2006-06-13 Boston Scientific Scimed, Inc. Multi-layer stent
US7371582B2 (en) 2002-01-23 2008-05-13 Boditechmed Inc. Lateral flow quantitative assay method and strip and laser-induced fluorescence detection device therefor
ATE362741T1 (de) * 2002-01-31 2007-06-15 Radi Medical Systems Sich auflösender stent
US7326245B2 (en) 2002-01-31 2008-02-05 Boston Scientific Scimed, Inc. Medical device for delivering biologically active material
US20030153901A1 (en) 2002-02-08 2003-08-14 Atrium Medical Corporation Drug delivery panel
US6887270B2 (en) 2002-02-08 2005-05-03 Boston Scientific Scimed, Inc. Implantable or insertable medical device resistant to microbial growth and biofilm formation
SI1764118T1 (sl) * 2002-02-15 2010-11-30 Gilead Palo Alto Inc Polimerna prevleka za medicinske priprave
DE10207161B4 (de) 2002-02-20 2004-12-30 Universität Hannover Verfahren zur Herstellung von Implantaten
US20030170605A1 (en) 2002-03-11 2003-09-11 Egan Visual Inc. Vapor deposited writing surfaces
US7022334B1 (en) 2002-03-20 2006-04-04 Advanced Cardiovascular Systems, Inc. Therapeutic composition and a method of coating implantable medical devices
US7927368B2 (en) 2002-03-25 2011-04-19 Kieran Murphy Llc Device viewable under an imaging beam
US6743463B2 (en) 2002-03-28 2004-06-01 Scimed Life Systems, Inc. Method for spray-coating a medical device having a tubular wall such as a stent
US7462366B2 (en) 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
EP1348402A1 (en) * 2002-03-29 2003-10-01 Advanced Laser Applications Holding S.A. Intraluminal endoprosthesis, radially expandable, perforated for drug delivery
US7799467B2 (en) 2002-04-08 2010-09-21 Massachusetts Institute Of Technology Solid polymer electrolytes from ethylene oxide-containing, layer-by-layer assembled films
US20030211135A1 (en) 2002-04-11 2003-11-13 Greenhalgh Skott E. Stent having electrospun covering and method
US20030204239A1 (en) 2002-04-26 2003-10-30 Wenda Carlyle Endovascular stent with a preservative coating
WO2003092791A2 (en) 2002-05-02 2003-11-13 Scimed Life Systems, Inc. Energetically-controlled delivery of biologically active material from an implanted medical device
AU2003234505A1 (en) 2002-05-03 2003-11-17 The General Hospital Corporation Involuted endovascular valve and method of construction
EP1505931A1 (en) 2002-05-20 2005-02-16 Orbus Medical Technologies, Inc. Drug eluting implantable medical device
US20040000540A1 (en) * 2002-05-23 2004-01-01 Soboyejo Winston O. Laser texturing of surfaces for biomedical implants
US7048767B2 (en) 2002-06-11 2006-05-23 Spire Corporation Nano-crystalline, homo-metallic, protective coatings
US20030236513A1 (en) 2002-06-19 2003-12-25 Scimed Life Systems, Inc. Implantable or insertable medical devices for controlled delivery of a therapeutic agent
US7789908B2 (en) 2002-06-25 2010-09-07 Boston Scientific Scimed, Inc. Elastomerically impregnated ePTFE to enhance stretch and recovery properties for vascular grafts and coverings
US6865810B2 (en) 2002-06-27 2005-03-15 Scimed Life Systems, Inc. Methods of making medical devices
WO2004004602A1 (en) 2002-07-08 2004-01-15 Abbott Laboratories Vascular Enterprises Limited Drug eluting stent and methods of manufacture
US20050096731A1 (en) 2002-07-11 2005-05-05 Kareen Looi Cell seeded expandable body
WO2004006976A1 (en) 2002-07-12 2004-01-22 Cook Incorporated Coated medical device
EP1382408B1 (en) 2002-07-15 2010-06-23 Hitachi Metals, Ltd. Method for producing porous sintered metals for filters
US20040137039A1 (en) 2002-07-22 2004-07-15 Trustees Of Stevens Institute Of Technology Methods for controlled release of molecules from layered polymer films
US7067606B2 (en) 2002-07-30 2006-06-27 University Of Connecticut Nonionic telechelic polymers incorporating polyhedral oligosilsesquioxane (POSS) and uses thereof
DE10235689A1 (de) 2002-07-31 2004-02-19 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Endovaskuläres Implantat zur Injektion eines Wirkstoffs in die Media eines Blutgefäßes
US20050163821A1 (en) 2002-08-02 2005-07-28 Hsing-Wen Sung Drug-eluting Biodegradable Stent and Delivery Means
US20040024448A1 (en) 2002-08-05 2004-02-05 Chang James W. Thermoplastic fluoropolymer-coated medical devices
US7255710B2 (en) 2002-08-06 2007-08-14 Icon Medical Corp. Helical stent with micro-latches
US6962822B2 (en) 2002-08-07 2005-11-08 International Business Machines Corporation Discrete nano-textured structures in biomolecular arrays, and method of use
DE10237572A1 (de) 2002-08-13 2004-02-26 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Stent mit polymerer Beschichtung
DE10237571A1 (de) 2002-08-13 2004-02-26 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Endovaskuläres Implantat mit aktiver Beschichtung
AU2003257604A1 (en) 2002-08-23 2004-03-29 Bridgestone Corporation Stent and process for producing the same
US7029495B2 (en) 2002-08-28 2006-04-18 Scimed Life Systems, Inc. Medical devices and methods of making the same
AU2003270070A1 (en) 2002-09-04 2004-03-29 Reva Medical, Inc. A slide and lock stent and method of manufacture from a single piece shape
US7758636B2 (en) 2002-09-20 2010-07-20 Innovational Holdings Llc Expandable medical device with openings for delivery of multiple beneficial agents
EP1402849B2 (en) 2002-09-20 2011-03-16 Abbott Laboratories Vascular Enterprises Limited Stent with rough surface and its manufacturing method
US7001422B2 (en) 2002-09-23 2006-02-21 Cordis Neurovascular, Inc Expandable stent and delivery system
US7060051B2 (en) 2002-09-24 2006-06-13 Scimed Life Systems, Inc. Multi-balloon catheter with hydrogel coating
US20040059409A1 (en) 2002-09-24 2004-03-25 Stenzel Eric B. Method of applying coatings to a medical device
EP1551569B1 (en) 2002-09-26 2017-05-10 Advanced Bio Prosthetic Surfaces, Ltd. Implantable materials having engineered surfaces and method of making same
US6971813B2 (en) 2002-09-27 2005-12-06 Labcoat, Ltd. Contact coating of prostheses
EP1548138A4 (en) 2002-09-30 2007-07-18 Nano Technology Inst Inc NANOCRYSTALLINE AUSTENITIC METAL MATERIAL IN BULK HAVING HIGH HARDNESS, RESISTANCE AND TENACITY, AND PROCESS FOR PRODUCING THE SAME
US6770729B2 (en) 2002-09-30 2004-08-03 Medtronic Minimed, Inc. Polymer compositions containing bioactive agents and methods for their use
US7794494B2 (en) 2002-10-11 2010-09-14 Boston Scientific Scimed, Inc. Implantable medical devices
US7976936B2 (en) 2002-10-11 2011-07-12 University Of Connecticut Endoprostheses
DE60336158D1 (de) 2002-10-11 2011-04-07 Univ Connecticut Auf semikristalline thermoplastische polyurethane die nanostrukturierte hartsegmente aufweisen basierenden formgedächtnispolymere
US20060271168A1 (en) 2002-10-30 2006-11-30 Klaus Kleine Degradable medical device
US20040088038A1 (en) 2002-10-30 2004-05-06 Houdin Dehnad Porous metal for drug-loaded stents
SE0203224D0 (sv) 2002-10-31 2002-10-31 Cerbio Tech Ab Method of making structured ceramic coatings and coated devices prepared with the method
US8221495B2 (en) 2002-11-07 2012-07-17 Abbott Laboratories Integration of therapeutic agent into a bioerodible medical device
AU2003291470A1 (en) 2002-11-08 2004-06-03 Innovational Holdings, Llc Expandable medical device and method for treating chronic total occlusions with local delivery of an angiogenic factor
US20040142014A1 (en) 2002-11-08 2004-07-22 Conor Medsystems, Inc. Method and apparatus for reducing tissue damage after ischemic injury
US7169178B1 (en) 2002-11-12 2007-01-30 Advanced Cardiovascular Systems, Inc. Stent with drug coating
US7144422B1 (en) 2002-11-13 2006-12-05 Advanced Cardiovascular Systems, Inc. Drug-eluting stent and methods of making the same
AU2003295535B2 (en) 2002-11-13 2007-12-20 Setagon, Inc. Medical devices having porous layers and methods for making same
US20050070989A1 (en) 2002-11-13 2005-03-31 Whye-Kei Lye Medical devices having porous layers and methods for making the same
DE10253634A1 (de) 2002-11-13 2004-05-27 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Endoprothese
US20060121080A1 (en) 2002-11-13 2006-06-08 Lye Whye K Medical devices having nanoporous layers and methods for making the same
DE10253633B4 (de) 2002-11-13 2011-08-11 BIOTRONIK GmbH & Co. KG, 12359 Tragstruktur
EP1567221A1 (en) 2002-11-15 2005-08-31 GMP Cardiac Care, Inc. Rail stent
US8449601B2 (en) 2002-11-19 2013-05-28 Boston Scientific Scimed, Inc. Medical devices
JP4119230B2 (ja) 2002-11-26 2008-07-16 株式会社 日立ディスプレイズ 表示装置
US6918869B2 (en) 2002-12-02 2005-07-19 Scimed Life Systems System for administering a combination of therapies to a body lumen
US7776926B1 (en) 2002-12-11 2010-08-17 Advanced Cardiovascular Systems, Inc. Biocompatible coating for implantable medical devices
DE10261822A1 (de) 2002-12-20 2004-07-01 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Helix-Steg-Verbindung
US6926735B2 (en) 2002-12-23 2005-08-09 Scimed Life Systems, Inc. Multi-lumen vascular grafts having improved self-sealing properties
US7666216B2 (en) 2002-12-24 2010-02-23 Novostent Corporation Delivery catheter for ribbon-type prosthesis and methods of use
US7846198B2 (en) 2002-12-24 2010-12-07 Novostent Corporation Vascular prosthesis and methods of use
US6725901B1 (en) 2002-12-27 2004-04-27 Advanced Cardiovascular Systems, Inc. Methods of manufacture of fully consolidated or porous medical devices
US7316710B1 (en) 2002-12-30 2008-01-08 Advanced Cardiovascular Systems, Inc. Flexible stent
US6896697B1 (en) 2002-12-30 2005-05-24 Advanced Cardiovascular Systems, Inc. Intravascular stent
US6803070B2 (en) 2002-12-30 2004-10-12 Scimed Life Systems, Inc. Apparatus and method for embedding nanoparticles in polymeric medical devices
US20040219214A1 (en) 2002-12-30 2004-11-04 Angiotech International Ag Tissue reactive compounds and compositions and uses thereof
US7105018B1 (en) 2002-12-30 2006-09-12 Advanced Cardiovascular Systems, Inc. Drug-eluting stent cover and method of use
US20040236415A1 (en) 2003-01-02 2004-11-25 Richard Thomas Medical devices having drug releasing polymer reservoirs
US20040143317A1 (en) 2003-01-17 2004-07-22 Stinson Jonathan S. Medical devices
US6852122B2 (en) 2003-01-23 2005-02-08 Cordis Corporation Coated endovascular AAA device
US7767219B2 (en) 2003-01-31 2010-08-03 Boston Scientific Scimed, Inc. Localized drug delivery using drug-loaded nanocapsules
US7311727B2 (en) 2003-02-05 2007-12-25 Board Of Trustees Of The University Of Arkansas Encased stent
US7172624B2 (en) 2003-02-06 2007-02-06 Boston Scientific Scimed, Inc. Medical device with magnetic resonance visibility enhancing structure
US20080038146A1 (en) 2003-02-10 2008-02-14 Jurgen Wachter Metal alloy for medical devices and implants
FR2851181B1 (fr) 2003-02-17 2006-05-26 Commissariat Energie Atomique Procede de revetement d'une surface
US20050079199A1 (en) 2003-02-18 2005-04-14 Medtronic, Inc. Porous coatings for drug release from medical devices
ATE422164T1 (de) 2003-02-18 2009-02-15 Medtronic Inc Verschlussbeständiger hydrocephalischer shunt
US20040167572A1 (en) 2003-02-20 2004-08-26 Roth Noah M. Coated medical devices
ATE485847T1 (de) 2003-02-21 2010-11-15 Sorin Biomedica Cardio Srl Verfahren zur herstellung eines stents und entsprechender stent
US20080051866A1 (en) 2003-02-26 2008-02-28 Chao Chin Chen Drug delivery devices and methods
US7001421B2 (en) 2003-02-28 2006-02-21 Medtronic Vascular, Inc. Stent with phenoxy primer coating
US6699282B1 (en) 2003-03-06 2004-03-02 Gelsus Research And Consulting, Inc. Method and apparatus for delivery of medication
US8281737B2 (en) * 2003-03-10 2012-10-09 Boston Scientific Scimed, Inc. Coated medical device and method for manufacturing the same
US6932930B2 (en) 2003-03-10 2005-08-23 Synecor, Llc Intraluminal prostheses having polymeric material with selectively modified crystallinity and methods of making same
DE10311729A1 (de) * 2003-03-18 2004-09-30 Schultheiss, Heinz-Peter, Prof. Dr. Endovaskuläres Implantat mit einer mindestens abschnittsweisen aktiven Beschichtung aus Ratjadon und/oder einem Ratjadon-Derivat
US20040202692A1 (en) 2003-03-28 2004-10-14 Conor Medsystems, Inc. Implantable medical device and method for in situ selective modulation of agent delivery
US20050022627A1 (en) 2003-04-03 2005-02-03 Cheng-Han Chen Oxidation resistant treatment for metallic medical devices
US7163555B2 (en) 2003-04-08 2007-01-16 Medtronic Vascular, Inc. Drug-eluting stent for controlled drug delivery
US20050216075A1 (en) 2003-04-08 2005-09-29 Xingwu Wang Materials and devices of enhanced electromagnetic transparency
US20050070996A1 (en) 2003-04-08 2005-03-31 Dinh Thomas Q. Drug-eluting stent for controlled drug delivery
US20040254419A1 (en) 2003-04-08 2004-12-16 Xingwu Wang Therapeutic assembly
US20050079132A1 (en) 2003-04-08 2005-04-14 Xingwu Wang Medical device with low magnetic susceptibility
US20050107870A1 (en) 2003-04-08 2005-05-19 Xingwu Wang Medical device with multiple coating layers
US20050149169A1 (en) 2003-04-08 2005-07-07 Xingwu Wang Implantable medical device
US7717953B2 (en) 2004-10-13 2010-05-18 Tryton Medical, Inc. Delivery system for placement of prosthesis at luminal OS
US7731747B2 (en) 2003-04-14 2010-06-08 Tryton Medical, Inc. Vascular bifurcation prosthesis with multiple thin fronds
US20060041182A1 (en) 2003-04-16 2006-02-23 Forbes Zachary G Magnetically-controllable delivery system for therapeutic agents
US20050221072A1 (en) 2003-04-17 2005-10-06 Nanosys, Inc. Medical device applications of nanostructured surfaces
US20040230176A1 (en) 2003-04-23 2004-11-18 Medtronic Vascular, Inc. System for treating a vascular condition that inhibits restenosis at stent ends
ATE494885T1 (de) 2003-04-25 2011-01-15 Boston Scient Scimed Inc Feste arzneimittelformulierung und vorrichtung zu ihrer aufbewahrung und kontrollierten abgabe
WO2004098565A2 (en) 2003-05-02 2004-11-18 Surmodics, Inc. Implantable controlled release bioactive agent delivery device
US8246974B2 (en) 2003-05-02 2012-08-21 Surmodics, Inc. Medical devices and methods for producing the same
US6923996B2 (en) 2003-05-06 2005-08-02 Scimed Life Systems, Inc. Processes for producing polymer coatings for release of therapeutic agent
US7279174B2 (en) 2003-05-08 2007-10-09 Advanced Cardiovascular Systems, Inc. Stent coatings comprising hydrophilic additives
US6846323B2 (en) * 2003-05-15 2005-01-25 Advanced Cardiovascular Systems, Inc. Intravascular stent
DE502004010042D1 (de) 2003-05-16 2009-10-22 Cinv Ag Verfahren zur beschichtung von substraten mit kohlenstoffbasiertem material
US20040236416A1 (en) 2003-05-20 2004-11-25 Robert Falotico Increased biocompatibility of implantable medical devices
DE10323628A1 (de) 2003-05-20 2004-12-30 Biotronik Ag Stents aus einem Material geringer Bruchdehnung
US20050211680A1 (en) 2003-05-23 2005-09-29 Mingwei Li Systems and methods for laser texturing of surfaces of a substrate
US20030216803A1 (en) 2003-05-28 2003-11-20 Ledergerber Walter J. Textured and drug eluting stent-grafts
US7041127B2 (en) 2003-05-28 2006-05-09 Ledergerber Walter J Textured and drug eluting coronary artery stent
US7297644B2 (en) 2003-05-28 2007-11-20 Air Products Polymers, L.P. Nonwoven binders with high wet/dry tensile strength ratio
US7270679B2 (en) 2003-05-30 2007-09-18 Warsaw Orthopedic, Inc. Implants based on engineered metal matrix composite materials having enhanced imaging and wear resistance
US6904658B2 (en) 2003-06-02 2005-06-14 Electroformed Stents, Inc. Process for forming a porous drug delivery layer
US6979348B2 (en) 2003-06-04 2005-12-27 Medtronic Vascular, Inc. Reflowed drug-polymer coated stent and method thereof
US7169179B2 (en) 2003-06-05 2007-01-30 Conor Medsystems, Inc. Drug delivery device and method for bi-directional drug delivery
TWI255580B (en) 2003-07-02 2006-05-21 Sony Corp MEMS type oscillator, process for fabricating the same, filter, and communication unit
FI20045223A (fi) 2004-06-15 2005-12-16 Bioretec Oy Monitoiminen biohajoava komposiitti ja kirurginen implantti, joka käsittää mainitun komposiitin
US20050021127A1 (en) * 2003-07-21 2005-01-27 Kawula Paul John Porous glass fused onto stent for drug retention
US20050021128A1 (en) * 2003-07-24 2005-01-27 Medtronic Vascular, Inc. Compliant, porous, rolled stent
ES2383328T3 (es) 2003-07-25 2012-06-20 Amgen, Inc Métodos relacionados con LDCAM y CRTAM
US7682603B2 (en) * 2003-07-25 2010-03-23 The Trustees Of The University Of Pennsylvania Polymersomes incorporating highly emissive probes
US20050027350A1 (en) 2003-07-30 2005-02-03 Biotronik Mess-Und Therapiegeraete Gmbh & Co Ingenieurbuero Berlin Endovascular implant for the injection of an active substance into the media of a blood vessel
US20050033417A1 (en) 2003-07-31 2005-02-10 John Borges Coating for controlled release of a therapeutic agent
JPWO2005011796A1 (ja) 2003-08-05 2006-09-14 株式会社カネカ 生体留置用ステント
US7479157B2 (en) 2003-08-07 2009-01-20 Boston Scientific Scimed, Inc. Stent designs which enable the visibility of the inside of the stent during MRI
US20050037047A1 (en) 2003-08-11 2005-02-17 Young-Ho Song Medical devices comprising spray dried microparticles
US7364585B2 (en) 2003-08-11 2008-04-29 Boston Scientific Scimed, Inc. Medical devices comprising drug-loaded capsules for localized drug delivery
US20050038501A1 (en) 2003-08-12 2005-02-17 Moore James E. Dynamic stent
US20050055085A1 (en) 2003-09-04 2005-03-10 Rivron Nicolas C. Implantable medical devices having recesses
US20050055080A1 (en) 2003-09-05 2005-03-10 Naim Istephanous Modulated stents and methods of making the stents
US7544381B2 (en) 2003-09-09 2009-06-09 Boston Scientific Scimed, Inc. Lubricious coatings for medical device
WO2005025449A2 (en) 2003-09-10 2005-03-24 Spheric Products, Ltd Cardiovascular stent with anti-platelet and angiogenic material
US7488343B2 (en) 2003-09-16 2009-02-10 Boston Scientific Scimed, Inc. Medical devices
US20050060020A1 (en) 2003-09-17 2005-03-17 Scimed Life Systems, Inc. Covered stent with biologically active material
CA2539692A1 (en) 2003-09-18 2005-03-31 Advanced Bio Prosthetic Surfaces, Ltd. Medical device having mems functionality and methods of making same
US7060319B2 (en) 2003-09-24 2006-06-13 Boston Scientific Scimed, Inc. method for using an ultrasonic nozzle to coat a medical appliance
US20050070990A1 (en) 2003-09-26 2005-03-31 Stinson Jonathan S. Medical devices and methods of making same
US7055237B2 (en) 2003-09-29 2006-06-06 Medtronic Vascular, Inc. Method of forming a drug eluting stent
US7198675B2 (en) 2003-09-30 2007-04-03 Advanced Cardiovascular Systems Stent mandrel fixture and method for selectively coating surfaces of a stent
US7618647B2 (en) 2003-10-03 2009-11-17 Boston Scientific Scimed, Inc. Using bucky paper as a therapeutic aid in medical applications
US7284677B2 (en) 2003-10-08 2007-10-23 Elizabeth Ann Guevara Bottle holding appliance and method for its use
WO2005042646A2 (en) 2003-10-30 2005-05-12 Applied Medical Resources Corporation Surface treatments and modifications using nanostructure materials
US7208172B2 (en) 2003-11-03 2007-04-24 Medlogics Device Corporation Metallic composite coating for delivery of therapeutic agents from the surface of implantable devices
US20050129731A1 (en) 2003-11-03 2005-06-16 Roland Horres Biocompatible, biostable coating of medical surfaces
US20050100577A1 (en) 2003-11-10 2005-05-12 Parker Theodore L. Expandable medical device with beneficial agent matrix formed by a multi solvent system
AU2004289362A1 (en) 2003-11-10 2005-05-26 Angiotech International Ag Intravascular devices and fibrosis-inducing agents
ES2718928T3 (es) 2003-11-14 2019-07-05 Wild River Consulting Group Llc Material compuesto de polímero metálico, un método para su extrusión y artículos conformados a partir del mismo
US20050113904A1 (en) 2003-11-25 2005-05-26 Shank Peter J. Composite stent with inner and outer stent elements and method of using the same
US20060085062A1 (en) 2003-11-28 2006-04-20 Medlogics Device Corporation Implantable stent with endothelialization factor
US20050119723A1 (en) 2003-11-28 2005-06-02 Medlogics Device Corporation Medical device with porous surface containing bioerodable bioactive composites and related methods
EP1535952B1 (en) 2003-11-28 2013-01-16 Universite Louis Pasteur Method for preparing crosslinked polyelectrolyte multilayer films
DE10357281A1 (de) 2003-12-05 2005-07-14 Hassel, Thomas, Dipl.-Ing. Gefäßstütze
DE10357334A1 (de) 2003-12-05 2005-07-07 Grönemeyer, Dietrich H. W., Prof. Dr.med. MR-kompatibles medizinisches Implantat
US20050131522A1 (en) 2003-12-10 2005-06-16 Stinson Jonathan S. Medical devices and methods of making the same
ES2635270T3 (es) 2003-12-12 2017-10-03 C.R.Bard, Inc. Dispositivos médicos implantables con recubrimientos de polímero fluorado, y métodos de recubrimiento de los mismos
DE10358502B3 (de) 2003-12-13 2005-04-07 Daimlerchrysler Ag Verfahren und Einrichtung zur Herstellung eines Hohlprofils
US8017178B2 (en) 2003-12-16 2011-09-13 Cardiac Pacemakers, Inc. Coatings for implantable electrodes
US7220816B2 (en) 2003-12-16 2007-05-22 Advanced Cardiovascular Systems, Inc. Biologically absorbable coatings for implantable devices based on poly(ester amides) and methods for fabricating the same
US20050137677A1 (en) 2003-12-17 2005-06-23 Rush Scott L. Endovascular graft with differentiable porosity along its length
US20050137679A1 (en) 2003-12-17 2005-06-23 Pfizer Inc Modified stent useful for delivery of drugs along stent strut
EP1701910A4 (en) 2003-12-18 2013-04-03 Massachusetts Inst Technology MAGNETIC NANOPARTICLES IMPROVED BIOPROCESSES
US8652502B2 (en) 2003-12-19 2014-02-18 Cordis Corporation Local vascular delivery of trichostatin A alone or in combination with sirolimus to prevent restenosis following vascular injury
US7261732B2 (en) 2003-12-22 2007-08-28 Henri Justino Stent mounted valve
US20070027532A1 (en) 2003-12-22 2007-02-01 Xingwu Wang Medical device
DE10361940A1 (de) * 2003-12-24 2005-07-28 Restate Patent Ag Degradationssteuerung biodegradierbarer Implantate durch Beschichtung
DE10361941A1 (de) 2003-12-24 2005-07-28 Restate Patent Ag Magnesiumhaltige Beschichtung
JP4887159B2 (ja) 2004-01-20 2012-02-29 クック・インコーポレイテッド 腔内人工器官装置およびその形成方法
US20050159805A1 (en) 2004-01-20 2005-07-21 Jan Weber Functional coatings and designs for medical implants
US20050159809A1 (en) 2004-01-21 2005-07-21 Medtronic Vascular, Inc. Implantable medical devices for treating or preventing restenosis
US7632299B2 (en) 2004-01-22 2009-12-15 Boston Scientific Scimed, Inc. Medical devices
US7854756B2 (en) 2004-01-22 2010-12-21 Boston Scientific Scimed, Inc. Medical devices
US8620406B2 (en) 2004-01-23 2013-12-31 Boston Scientific Scimed, Inc. Medical devices visible by magnetic resonance imaging
US7393589B2 (en) 2004-01-30 2008-07-01 Ionbond, Inc. Dual layer diffusion bonded chemical vapor coating for medical implants
ITTO20040056A1 (it) 2004-02-05 2004-05-05 Sorin Biomedica Cardio Spa Stent per l'erogazione endoliminale di principi o agenti attivi
DE102004029611A1 (de) 2004-02-06 2005-08-25 Restate Patent Ag Implantat zur Freisetzung eines Wirkstoffs in ein von einem Körpermedium durchströmtes Gefäß
US7442681B2 (en) 2004-02-10 2008-10-28 University Of Virginia Patent Foundation Method of inhibiting vascular permeability
EP1718245A4 (en) 2004-02-12 2008-03-19 Univ Akron MECHANICALLY APPLIED COATINGS OF MEDICAL DEVICES
US20050180919A1 (en) 2004-02-12 2005-08-18 Eugene Tedeschi Stent with radiopaque and encapsulant coatings
US8049137B2 (en) 2004-02-13 2011-11-01 Boston Scientific Scimed, Inc. Laser shock peening of medical devices
US8137397B2 (en) 2004-02-26 2012-03-20 Boston Scientific Scimed, Inc. Medical devices
US7294145B2 (en) 2004-02-26 2007-11-13 Boston Scientific Scimed, Inc. Stent with differently coated inside and outside surfaces
US6979473B2 (en) 2004-03-15 2005-12-27 Boston Scientific Scimed, Inc. Method for fine bore orifice spray coating of medical devices and pre-filming atomization
US7744644B2 (en) 2004-03-19 2010-06-29 Boston Scientific Scimed, Inc. Medical articles having regions with polyelectrolyte multilayer coatings for regulating drug release
US8435287B2 (en) * 2004-03-30 2013-05-07 Toyo Advanced Technologies Co., Ltd. Stent and method for fabricating the same
US20050222671A1 (en) 2004-03-31 2005-10-06 Schaeffer Darin G Partially biodegradable stent
US8715340B2 (en) 2004-03-31 2014-05-06 Merlin Md Pte Ltd. Endovascular device with membrane
US20050220853A1 (en) 2004-04-02 2005-10-06 Kinh-Luan Dao Controlled delivery of therapeutic agents from medical articles
US7541048B2 (en) 2004-04-06 2009-06-02 Surmodics, Inc. Coating compositions for bioactive agents
US20050228477A1 (en) 2004-04-09 2005-10-13 Xtent, Inc. Topographic coatings and coating methods for medical devices
US20050228491A1 (en) 2004-04-12 2005-10-13 Snyder Alan J Anti-adhesive surface treatments
CA2502018A1 (en) 2004-04-16 2005-10-16 Conor Medsystems, Inc. Bioresorbable stent delivery system
US7070576B2 (en) 2004-04-30 2006-07-04 Boston Scientific Scimed, Inc. Directional cutting balloon
US20050251245A1 (en) 2004-05-05 2005-11-10 Karl Sieradzki Methods and apparatus with porous materials
US7955371B2 (en) 2004-05-12 2011-06-07 Medtronic Vascular, Inc. System and method for stent deployment and infusion of a therapeutic agent into tissue adjacent to the stent ends
ATE374627T1 (de) 2004-05-20 2007-10-15 Boston Scient Ltd Medizinische vorrichtungen und verfahren zu ihrer herstellung
US7758892B1 (en) 2004-05-20 2010-07-20 Boston Scientific Scimed, Inc. Medical devices having multiple layers
US20060100696A1 (en) 2004-11-10 2006-05-11 Atanasoska Ljiljana L Medical devices and methods of making the same
DE602005025215D1 (de) 2004-05-21 2011-01-20 Micro Therapeutics Inc Mit biologischen oder biologisch abbaubaren oder synthetischen polymeren oder fasern umschlungene metallspulen zur embolisierung einer körperhöhle
DE102004026104A1 (de) 2004-05-25 2005-12-15 Restate Patent Ag Implantat zur Gefäßligatur
US20050266039A1 (en) 2004-05-27 2005-12-01 Jan Weber Coated medical device and method for making the same
US20050266040A1 (en) 2004-05-28 2005-12-01 Brent Gerberding Medical devices composed of porous metallic materials for delivering biologically active materials
US7695775B2 (en) 2004-06-04 2010-04-13 Applied Microstructures, Inc. Controlled vapor deposition of biocompatible coatings over surface-treated substrates
US7794490B2 (en) 2004-06-22 2010-09-14 Boston Scientific Scimed, Inc. Implantable medical devices with antimicrobial and biodegradable matrices
EP2111881A1 (en) * 2004-07-05 2009-10-28 Ziscoat N.V. Biocompatible coating of medical devices comprising molecular sieves
US20060009839A1 (en) * 2004-07-12 2006-01-12 Scimed Life Systems, Inc. Composite vascular graft including bioactive agent coating and biodegradable sheath
US7078108B2 (en) * 2004-07-14 2006-07-18 The Regents Of The University Of California Preparation of high-strength nanometer scale twinned coating and foil
US20060015361A1 (en) * 2004-07-16 2006-01-19 Jurgen Sattler Method and system for customer contact reporting
US7269700B2 (en) * 2004-07-26 2007-09-11 Integrated Device Technology, Inc. Status bus accessing only available quadrants during loop mode operation in a multi-queue first-in first-out memory system
US20060025848A1 (en) 2004-07-29 2006-02-02 Jan Weber Medical device having a coating layer with structural elements therein and method of making the same
US20060275554A1 (en) 2004-08-23 2006-12-07 Zhibo Zhao High performance kinetic spray nozzle
US7507433B2 (en) 2004-09-03 2009-03-24 Boston Scientific Scimed, Inc. Method of coating a medical device using an electrowetting process
DE102004043231A1 (de) 2004-09-07 2006-03-09 Biotronik Vi Patent Ag Endoprothese aus einer Magnesiumlegierung
DE502005008226D1 (de) 2004-09-07 2009-11-12 Biotronik Vi Patent Ag Endoprothese aus einer Magnesiumlegierung
DE102004043232A1 (de) 2004-09-07 2006-03-09 Biotronik Vi Patent Ag Endoprothese aus einer Magnesiumlegierung
DE102004044679A1 (de) 2004-09-09 2006-03-16 Biotronik Vi Patent Ag Implantat mit geringer Radialfestigkeit
US7229471B2 (en) 2004-09-10 2007-06-12 Advanced Cardiovascular Systems, Inc. Compositions containing fast-leaching plasticizers for improved performance of medical devices
US7901451B2 (en) 2004-09-24 2011-03-08 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method for treating restenosis
US20060075044A1 (en) 2004-09-30 2006-04-06 Fox Kevin D System and method for electronic contact list-based search and display
US9011831B2 (en) 2004-09-30 2015-04-21 Advanced Cardiovascular Systems, Inc. Methacrylate copolymers for medical devices
US20060075092A1 (en) 2004-10-06 2006-04-06 Kabushiki Kaisha Toshiba System and method for determining the status of users and devices from access log information
US7344560B2 (en) 2004-10-08 2008-03-18 Boston Scientific Scimed, Inc. Medical devices and methods of making the same
US20060085065A1 (en) 2004-10-15 2006-04-20 Krause Arthur A Stent with auxiliary treatment structure
US7862835B2 (en) 2004-10-27 2011-01-04 Boston Scientific Scimed, Inc. Method of manufacturing a medical device having a porous coating thereon
US20060088566A1 (en) 2004-10-27 2006-04-27 Scimed Life Systems, Inc.,A Corporation Method of controlling drug release from a coated medical device through the use of nucleating agents
US7958840B2 (en) 2004-10-27 2011-06-14 Surmodics, Inc. Method and apparatus for coating of substrates
US8029563B2 (en) 2004-11-29 2011-10-04 Gore Enterprise Holdings, Inc. Implantable devices with reduced needle puncture site leakage
US20060122694A1 (en) 2004-12-03 2006-06-08 Stinson Jonathan S Medical devices and methods of making the same
US20060129215A1 (en) 2004-12-09 2006-06-15 Helmus Michael N Medical devices having nanostructured regions for controlled tissue biocompatibility and drug delivery
US7632390B2 (en) 2004-12-10 2009-12-15 Ryszard Rokicki Apparatus and method for enhancing electropolishing utilizing magnetic fields
US20080140172A1 (en) 2004-12-13 2008-06-12 Robert Hunt Carpenter Multi-Wall Expandable Device Capable Of Drug Delivery Related Applications
US20060129225A1 (en) 2004-12-15 2006-06-15 Kopia Gregory A Device for the delivery of a cardioprotective agent to ischemic reperfused myocardium
US7632307B2 (en) 2004-12-16 2009-12-15 Advanced Cardiovascular Systems, Inc. Abluminal, multilayer coating constructs for drug-delivery stents
DK1674117T3 (en) 2004-12-24 2018-12-10 Hexacath MECHANICAL SUBJECT WITH IMPROVED DEFORMABILITY
US7432327B2 (en) 2004-12-30 2008-10-07 Sabic Innovative Plastics Ip B.V. Transparent polymeric compositions comprising polysiloxane-polycarbonate copolymer, articles made therefrom and methods of making same
US20060149363A1 (en) 2005-01-06 2006-07-06 Scimed Life Systems, Inc. Optimally expanded, collagen sealed ePTFE graft with improved tissue ingrowth
US7727273B2 (en) 2005-01-13 2010-06-01 Boston Scientific Scimed, Inc. Medical devices and methods of making the same
CA2593789A1 (en) 2005-01-14 2006-07-20 National Research Council Of Canada Implantable biomimetic prosthetic bone
DE102005003188A1 (de) 2005-01-20 2006-07-27 Restate Patent Ag Medizinisches Implantat aus einer amorphen oder nanokristallinen Legierung
JP5097536B2 (ja) 2005-01-28 2012-12-12 テルモ株式会社 血管内インプラント
US8057543B2 (en) 2005-01-28 2011-11-15 Greatbatch Ltd. Stent coating for eluting medication
US20060177480A1 (en) 2005-02-10 2006-08-10 Hsing-Wen Sung Drug-eluting biodegradable stent
US20070003589A1 (en) * 2005-02-17 2007-01-04 Irina Astafieva Coatings for implantable medical devices containing attractants for endothelial cells
US7699863B2 (en) 2005-03-01 2010-04-20 Tulip Medical Ltd. Bioerodible self-deployable intragastric implants
US20060200229A1 (en) 2005-03-03 2006-09-07 Robert Burgermeister Geometry and material for use in high strength, high flexibility, controlled recoil drug eluting stents
US7540995B2 (en) 2005-03-03 2009-06-02 Icon Medical Corp. Process for forming an improved metal alloy stent
WO2006110197A2 (en) 2005-03-03 2006-10-19 Icon Medical Corp. Polymer biodegradable medical device
US8323333B2 (en) 2005-03-03 2012-12-04 Icon Medical Corp. Fragile structure protective coating
US20060198869A1 (en) 2005-03-03 2006-09-07 Icon Medical Corp. Bioabsorable medical devices
US7727278B2 (en) 2005-03-04 2010-06-01 Rti Biologics, Inc. Self fixing assembled bone-tendon-bone graft
US20060199876A1 (en) 2005-03-04 2006-09-07 The University Of British Columbia Bioceramic composite coatings and process for making same
DE102005013221A1 (de) 2005-03-17 2006-09-21 Biotronik Vi Patent Ag System zur Behandlung ausgedehnter obliterierender Erkrankungen eines Gefäßes
KR20070120158A (ko) 2005-03-18 2007-12-21 신벤션 아게 다공성 소결 금속 물질의 제조 방법
US9056157B2 (en) 2005-03-24 2015-06-16 Medtronic Vascular, Inc. Hybrid biodegradable/non-biodegradable stent, delivery system and method of treating a vascular condition
US20060229715A1 (en) 2005-03-29 2006-10-12 Sdgi Holdings, Inc. Implants incorporating nanotubes and methods for producing the same
US9125968B2 (en) 2005-03-30 2015-09-08 Boston Scientific Scimed, Inc. Polymeric/ceramic composite materials for use in medical devices
CA2819332C (en) 2005-03-31 2016-09-13 Innovational Holdings, Llc System and method for loading a beneficial agent into a medical device
US7641983B2 (en) 2005-04-04 2010-01-05 Boston Scientific Scimed, Inc. Medical devices including composites
EP3225216A1 (en) * 2005-04-05 2017-10-04 Elixir Medical Corporation Degradable implantable medical devices
US20060233941A1 (en) 2005-04-15 2006-10-19 Boston Scientific Scimed, Inc. Method of coating a medical device utilizing an ion-based thin film deposition technique, a system for coating a medical device, and a medical device produced by the method
WO2006116492A2 (en) * 2005-04-26 2006-11-02 Christodoulos Stefanadis Method and devices for treatment of vulnerable (unstable) and/or stable atherosclerotic plaque by disrupting pathologic vasa vasorum of the atherosclerotic plaque
US8734851B2 (en) 2005-04-29 2014-05-27 Wisconsin Alumni Research Foundation Localized delivery of nucleic acid by polyelectrolyte assemblies
US7637941B1 (en) 2005-05-11 2009-12-29 Advanced Cardiovascular Systems, Inc. Endothelial cell binding coatings for rapid encapsulation of bioerodable stents
DE102005024151A1 (de) 2005-05-23 2006-11-30 Thomas Nicola Vorrichtung zur Peritonealdialyse
US20060276875A1 (en) 2005-05-27 2006-12-07 Stinson Jonathan S Medical devices
EP1890648B1 (en) 2005-06-06 2017-08-09 Innovational Holdings, LLC Implantable medical device with openings for delivery of beneficial agents with combination release kinetics
FI20055304L (fi) 2005-06-13 2007-02-20 Bioretec Oy Bioabsorboituva implantti, jolla on muuttuva ominaisuus
US8273117B2 (en) 2005-06-22 2012-09-25 Integran Technologies Inc. Low texture, quasi-isotropic metallic stent
EP1896091B1 (en) 2005-06-30 2011-06-22 Accord Biomaterials, Inc. Nitric oxide coatings for medical devices
DE102005031868A1 (de) * 2005-07-04 2007-01-18 Biotronik Vi Patent Ag Arzneimitteldepot zur parenteralen, insbesondere intravaskulären Arzneimittelfreisetzung
US20070038176A1 (en) 2005-07-05 2007-02-15 Jan Weber Medical devices with machined layers for controlled communications with underlying regions
DE102005032604A1 (de) 2005-07-13 2007-01-18 Gfe Medizintechnik Gmbh Resorbierbares, in den Körper einsetzbares medizinisches Element, insbesondere resorbierbares Implantat
US7465782B2 (en) * 2005-07-13 2008-12-16 E.I Du Pont De Nemours & Company Method for making polybenzobisoxazole containing fiber
ES2376713T3 (es) 2005-07-25 2012-03-16 Invatec S.P.A. Prótesis endoluminal.
US7778684B2 (en) 2005-08-08 2010-08-17 Boston Scientific Scimed, Inc. MRI resonator system with stent implant
US20070034615A1 (en) 2005-08-15 2007-02-15 Klaus Kleine Fabricating medical devices with an ytterbium tungstate laser
US20070038290A1 (en) 2005-08-15 2007-02-15 Bin Huang Fiber reinforced composite stents
US7597924B2 (en) 2005-08-18 2009-10-06 Boston Scientific Scimed, Inc. Surface modification of ePTFE and implants using the same
US20070045252A1 (en) 2005-08-23 2007-03-01 Klaus Kleine Laser induced plasma machining with a process gas
US9248034B2 (en) 2005-08-23 2016-02-02 Advanced Cardiovascular Systems, Inc. Controlled disintegrating implantable medical devices
US20070050009A1 (en) 2005-08-30 2007-03-01 Aiden Flanagan Bioabsorbable stent
US20070048350A1 (en) 2005-08-31 2007-03-01 Robert Falotico Antithrombotic coating for drug eluting medical devices
US8663308B2 (en) 2005-09-19 2014-03-04 Cook Medical Technologies Llc Graft with bioabsorbable support frame
US20070073385A1 (en) 2005-09-20 2007-03-29 Cook Incorporated Eluting, implantable medical device
US20070065418A1 (en) 2005-09-20 2007-03-22 Franco Vallana Method and device for cellular therapy
US20070073390A1 (en) 2005-09-23 2007-03-29 Medlogics Device Corporation Methods and devices for enhanced adhesion between metallic substrates and bioactive material-containing coatings
US20070264199A1 (en) 2005-09-26 2007-11-15 Labhasetwar Vinod D Magnetic nanoparticle composition and methods for using the same
US20090043374A1 (en) 2005-10-05 2009-02-12 Kaneka Corporation Stent to be Placed in the Living Body
US20070141106A1 (en) * 2005-10-19 2007-06-21 Bonutti Peter M Drug eluting implant
US7563277B2 (en) 2005-10-24 2009-07-21 Cook Incorporated Removable covering for implantable frame projections
US20070104753A1 (en) 2005-11-04 2007-05-10 Aiden Flanagan Medical device with a coating comprising an active form and an inactive form of therapeutic agent(s)
US9440003B2 (en) 2005-11-04 2016-09-13 Boston Scientific Scimed, Inc. Medical devices having particle-containing regions with diamond-like coatings
US20070106347A1 (en) 2005-11-09 2007-05-10 Wun-Chen Lin Portable medical and cosmetic photon emission adjustment device and method using the same
US8034101B2 (en) 2005-11-16 2011-10-11 National Institute For Materials Science Magnesium-based biodegradable metallic material
US20070135908A1 (en) 2005-12-08 2007-06-14 Zhao Jonathon Z Absorbable stent comprising coating for controlling degradation and maintaining pH neutrality
US20070134288A1 (en) 2005-12-13 2007-06-14 Edward Parsonage Anti-adhesion agents for drug coatings
US8518100B2 (en) 2005-12-19 2013-08-27 Advanced Cardiovascular Systems, Inc. Drug eluting stent for the treatment of dialysis graft stenoses
US20070148251A1 (en) 2005-12-22 2007-06-28 Hossainy Syed F A Nanoparticle releasing medical devices
CA2626717C (en) 2005-12-30 2014-10-21 C.R. Bard Inc. Stent with bio-resorbable connector and methods
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
CN100396120C (zh) 2006-01-09 2008-06-18 华为技术有限公司 一种用户设备获得组播节目地址的方法和***
US20070160641A1 (en) 2006-01-12 2007-07-12 Eun-Hyun Jang Coated medical devices and methods of making the same
US20070173923A1 (en) 2006-01-20 2007-07-26 Savage Douglas R Drug reservoir stent
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
US20070184083A1 (en) 2006-02-07 2007-08-09 Medtronic Vascular, Inc. Drug-Eluting Device for Treatment of Chronic Total Occlusions
US20070190104A1 (en) 2006-02-13 2007-08-16 Kamath Kalpana R Coating comprising an adhesive polymeric material for a medical device and method of preparing the same
US20070191931A1 (en) 2006-02-16 2007-08-16 Jan Weber Bioerodible endoprostheses and methods of making the same
US9526814B2 (en) 2006-02-16 2016-12-27 Boston Scientific Scimed, Inc. Medical balloons and methods of making the same
ATE551966T1 (de) 2006-02-28 2012-04-15 Straumann Holding Ag Zweiteiliges implantat mit hydroxylierter kontaktoberfläche für weichgewebe
US7955636B2 (en) 2006-03-03 2011-06-07 C.R. Bard, Inc. Antimicrobial coating
US8585753B2 (en) 2006-03-04 2013-11-19 John James Scanlon Fibrillated biodegradable prosthesis
US8597341B2 (en) 2006-03-06 2013-12-03 David Elmaleh Intravascular device with netting system
EP1834606B1 (en) 2006-03-16 2013-04-24 CID S.p.A. Stents
EP1835042A1 (en) 2006-03-18 2007-09-19 Acrostak Corp. Magnesium-based alloy with improved combination of mechanical and corrosion characteristics
EP1997522B1 (en) 2006-03-20 2015-05-13 National Institute for Materials Science Method of controlling degradation time of a biodegradable device
US20070224244A1 (en) 2006-03-22 2007-09-27 Jan Weber Corrosion resistant coatings for biodegradable metallic implants
US20070225799A1 (en) 2006-03-24 2007-09-27 Medtronic Vascular, Inc. Stent, intraluminal stent delivery system, and method of treating a vascular condition
US8187620B2 (en) 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
DE102006015457A1 (de) 2006-03-31 2007-10-04 Biotronik Vi Patent Ag Magnesiumlegierung und dazugehöriges Herstellungsverfahren
BRPI0710137B8 (pt) 2006-04-12 2021-06-22 Arterial Remodeling Tech S A método para diminuição das superfícies afiadas e/ou irregularidades de um stent polimérico
US8048150B2 (en) 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
US20070244541A1 (en) 2006-04-18 2007-10-18 Medtronic Vascular, Inc., A Delaware Corporation Methods and Devices for Contributing to Improved Stent Graft Fixation
US20070250155A1 (en) 2006-04-24 2007-10-25 Advanced Cardiovascular Systems, Inc. Bioabsorbable medical device
US7955383B2 (en) 2006-04-25 2011-06-07 Medtronics Vascular, Inc. Laminated implantable medical device having a metallic coating
US9155646B2 (en) 2006-04-27 2015-10-13 Brs Holdings, Llc Composite stent with bioremovable ceramic flakes
US20080051335A1 (en) 2006-05-02 2008-02-28 Kleiner Lothar W Methods, compositions and devices for treating lesioned sites using bioabsorbable carriers
US20070264303A1 (en) 2006-05-12 2007-11-15 Liliana Atanasoska Coating for medical devices comprising an inorganic or ceramic oxide and a therapeutic agent
WO2007133782A1 (en) 2006-05-15 2007-11-22 Tyco Healthcare Group Lp Antimicrobial coatings
WO2007136969A2 (en) 2006-05-16 2007-11-29 Medtronic Vascular, Inc. Bioabsorbable magnesium-reinforced polymer stents
CA2651982C (en) 2006-05-17 2014-07-15 Debiotech S.A. Anisotropic nanoporous coating for medical implants
US20070270942A1 (en) 2006-05-19 2007-11-22 Medtronic Vascular, Inc. Galvanic Corrosion Methods and Devices for Fixation of Stent Grafts
US20070282432A1 (en) 2006-05-31 2007-12-06 Stinson Jonathan S Implantable medical endoprostheses
US20070281073A1 (en) 2006-06-01 2007-12-06 Gale David C Enhanced adhesion of drug delivery coatings on stents
US20070281117A1 (en) 2006-06-02 2007-12-06 Xtent, Inc. Use of plasma in formation of biodegradable stent coating
WO2007142579A1 (en) 2006-06-05 2007-12-13 Bactiguard Ab A polymer matrix, uses thereof and a method of manufacturing the same
GB0612028D0 (en) 2006-06-16 2006-07-26 Imp Innovations Ltd Bioactive glass
DE102006029247A1 (de) 2006-06-26 2007-12-27 Biotronik Vi Patent Ag Implantat mit einer Cholesterol- oder Cholesterolester-haltigen Beschichtung
US8815275B2 (en) * 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
CA2655793A1 (en) * 2006-06-29 2008-01-03 Boston Scientific Limited Medical devices with selective coating
DE102006030588A1 (de) 2006-07-03 2008-01-10 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Flüssigkeitsstrahlgeführtes Ätzverfahren zum Materialabtrag an Festkörpern sowie dessen Verwendung
US9265866B2 (en) 2006-08-01 2016-02-23 Abbott Cardiovascular Systems Inc. Composite polymeric and metallic stent with radiopacity
US8052743B2 (en) 2006-08-02 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis with three-dimensional disintegration control
US20080124373A1 (en) 2006-08-02 2008-05-29 Inframat Corporation Lumen - supporting devices and methods of making and using
US20080069854A1 (en) 2006-08-02 2008-03-20 Inframat Corporation Medical devices and methods of making and using
US20080033522A1 (en) 2006-08-03 2008-02-07 Med Institute, Inc. Implantable Medical Device with Particulate Coating
DE102006038232A1 (de) 2006-08-07 2008-02-14 Biotronik Vi Patent Ag Endoprothese und Verfahren zur Herstellung einer solchen
DE102006038237A1 (de) 2006-08-07 2008-02-14 Biotronik Vi Patent Ag Markerlegierung
DE102006038235A1 (de) 2006-08-07 2008-02-14 Biotronik Vi Patent Ag Verbesserung der Stabilität biodegradierbarer metallischer Stents, Verfahren und Verwendung
DE102006038231A1 (de) 2006-08-07 2008-02-14 Biotronik Vi Patent Ag Implantat aus einem biokorrodierbaren metallischen Werkstoff mit einer Beschichtung aus einer Organosiliziumverbindung
DE102006038233A1 (de) 2006-08-07 2008-02-14 Biotronik Vi Patent Ag Markerkomposit für medizinische Implantate
DE102006038238A1 (de) 2006-08-07 2008-02-14 Biotronik Vi Patent Ag Röntgenmarker für medizinische Implantate aus einem biokorrodierbaren metallischen Werkstoff
DE102006038241A1 (de) 2006-08-07 2008-02-14 Biotronik Vi Patent Ag Stent mit einer genisteinhaltigen Beschichtung oder Kavitätenfüllung
DE102006038236A1 (de) 2006-08-07 2008-02-14 Biotronik Vi Patent Ag Biodegradierbarer Stent mit einer aktiven Beschichtung
US20080058921A1 (en) 2006-08-09 2008-03-06 Lindquist Jeffrey S Improved adhesion of a polymeric coating of a drug eluting stent
DE102006039346A1 (de) 2006-08-22 2008-03-13 Biotronik Vi Patent Ag Biokorrodierbares metallisches Implantat mit einer Beschichtung oder Kavitätenfüllung aus einem PEG/PLGA-Copolymer
US20080050413A1 (en) 2006-08-23 2008-02-28 Ronald Adrianus Maria Horvers Medical stent provided with a combination of melatonin and paclitaxel
US20080051881A1 (en) 2006-08-24 2008-02-28 Feng James Q Medical devices comprising porous layers for the release of therapeutic agents
CA2662473A1 (en) 2006-09-06 2008-03-13 Boston Scientific Limited Medical devices having nanostructured coating for macromolecule delivery
DE102006042313A1 (de) 2006-09-06 2008-03-27 Biotronik Vi Patent Ag Biokorrodierbares metallisches Implantat mit einer Beschichtung oder Kavitätenfüllung aus Gelatine
EP2068757B1 (en) 2006-09-14 2011-05-11 Boston Scientific Limited Medical devices with drug-eluting coating
WO2008034048A2 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprosthesis with biostable inorganic layers
WO2008034031A2 (en) * 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprostheses and methods of making the same
CA2663271A1 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprostheses and methods of making the same
WO2008034030A2 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Magnetized bioerodible endoprosthesis
US20080071348A1 (en) 2006-09-15 2008-03-20 Boston Scientific Scimed, Inc. Medical Devices
WO2008034013A2 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Medical devices and methods of making the same
WO2008034050A2 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Endoprosthesis containing magnetic induction particles
US7955382B2 (en) 2006-09-15 2011-06-07 Boston Scientific Scimed, Inc. Endoprosthesis with adjustable surface features
JP2010503483A (ja) 2006-09-18 2010-02-04 ボストン サイエンティフィック リミテッド 医療装置
WO2008036548A2 (en) 2006-09-18 2008-03-27 Boston Scientific Limited Endoprostheses
US20080071358A1 (en) 2006-09-18 2008-03-20 Boston Scientific Scimed, Inc. Endoprostheses
EP2073764A2 (en) 2006-09-18 2009-07-01 Boston Scientific Limited Controlling biodegradation of a medical instrument
ES2547011T3 (es) 2006-09-22 2015-09-30 U & I Corporation Implantes que comprenden metales biodegradables y procedimiento para la fabricación de los mismos
US7557167B2 (en) 2006-09-28 2009-07-07 Gore Enterprise Holdings, Inc. Polyester compositions, methods of manufacturing said compositions, and articles made therefrom
US8394488B2 (en) 2006-10-06 2013-03-12 Cordis Corporation Bioabsorbable device having composite structure for accelerating degradation
DE102006048819A1 (de) 2006-10-10 2008-04-17 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Vorrichtung mit einem Grundkörper
US20080090097A1 (en) 2006-10-11 2008-04-17 The Penn State Research Foundation Chemically and physically tailored structured thin film assemblies for corrosion prevention or promotion
US20080097577A1 (en) 2006-10-20 2008-04-24 Boston Scientific Scimed, Inc. Medical device hydrogen surface treatment by electrochemical reduction
CA2668408A1 (en) 2006-11-03 2008-05-15 Boston Scientific Limited Ion bombardment of medical devices
US20080243113A1 (en) 2006-11-08 2008-10-02 Shastri V Prasad Modification of stent surfaces to impart functionality
US20080294236A1 (en) 2007-05-23 2008-11-27 Boston Scientific Scimed, Inc. Endoprosthesis with Select Ceramic and Polymer Coatings
US7981150B2 (en) 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
US7919137B2 (en) 2006-11-13 2011-04-05 Boston Scientific Scimed, Inc. Medical devices having adherent polymeric layers with depth-dependent properties
US8414525B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8414526B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
CA2671850A1 (en) 2006-12-08 2008-06-19 Massachusetts Institute Of Technology Delivery of nanoparticles and/or agents to cells
AU2007331453A1 (en) 2006-12-15 2008-06-19 Coloplast A/S Coatings prepared from poly(ethylene oxide) and photo-initator-containing scaffolds
US7651527B2 (en) * 2006-12-15 2010-01-26 Medtronic Vascular, Inc. Bioresorbable stent
DE102006060501A1 (de) 2006-12-19 2008-06-26 Biotronik Vi Patent Ag Verfahren zur Herstellung einer korrosionshemmenden Beschichtung auf einem Implantat aus einer biokorrodierbaren Magnesiumlegierung sowie nach dem Verfahren hergestelltes Implantat
JP2010512947A (ja) 2006-12-20 2010-04-30 ボストン サイエンティフィック リミテッド 治療薬を送達するためのコーティングを備えたステント
US7939095B2 (en) 2006-12-21 2011-05-10 Cordis Corporation Crosslinked silane coating for medical devices
US9034456B2 (en) 2006-12-28 2015-05-19 Boston Scientific Scimed, Inc. Medical devices and methods of making the same
WO2008083190A2 (en) 2006-12-28 2008-07-10 Boston Scientific Limited Bioerodible endoprostheses and methods of making same
US20080171929A1 (en) 2007-01-11 2008-07-17 Katims Jefferson J Method for standardizing spacing between electrodes, and medical tape electrodes
WO2008087213A1 (en) 2007-01-19 2008-07-24 Cinvention Ag Porous, degradable implant made by powder molding
US20080177378A1 (en) 2007-01-19 2008-07-24 Civention Ag Partially bioabsorbable implant
DE102007003708A1 (de) 2007-01-25 2008-07-31 Biotronik Vi Patent Ag Mit Biomolekülen beschichtete Stents sowie Verfahren zu deren Herstellung
JP2010516403A (ja) 2007-01-26 2010-05-20 ボストン サイエンティフィック リミテッド 植込み型医療用内部人工器官
DE102007004589A1 (de) 2007-01-30 2008-07-31 Orlowski, Michael, Dr. Bioresorbierbarer Metallstent mit kontrollierter Resorption
WO2008092435A2 (de) 2007-01-30 2008-08-07 Hemoteq Ag Biologisch abbaubare gefässstütze
US7758635B2 (en) 2007-02-13 2010-07-20 Boston Scientific Scimed, Inc. Medical device including cylindrical micelles
WO2008098922A2 (en) 2007-02-13 2008-08-21 Cinvention Ag Biodegradable porous stent
WO2008098924A2 (en) 2007-02-13 2008-08-21 Cinvention Ag Medical devices with extended or multiple reservoirs
WO2008098927A2 (en) 2007-02-13 2008-08-21 Cinvention Ag Degradable reservoir implants
US8273402B2 (en) 2007-02-26 2012-09-25 Medtronic Vascular, Inc. Drug coated stent with magnesium topcoat
US20080208352A1 (en) 2007-02-27 2008-08-28 Medtronic Vascular, Inc. Stent Having Controlled Porosity for Improved Ductility
US20080208308A1 (en) 2007-02-27 2008-08-28 Medtronic Vascular, Inc. High Temperature Oxidation-Reduction Process to Form Porous Structures on a Medical Implant
US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
CN101636130B (zh) 2007-03-23 2012-04-25 因瓦泰克技术中心有限公司 腔内假体
US20080243240A1 (en) 2007-03-26 2008-10-02 Medtronic Vascular, Inc. Biodegradable Metal Barrier Layer for a Drug-Eluting Stent
US20080243234A1 (en) 2007-03-27 2008-10-02 Medtronic Vascular, Inc. Magnesium Alloy Stent
DE102007015670A1 (de) 2007-03-31 2008-10-02 Biotronik Vi Patent Ag Stent mit radial expandierbarem Grundkörper
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
US20080249600A1 (en) 2007-04-06 2008-10-09 Boston Scientific Scimed, Inc. Stents with drug reservoir layer and methods of making and using the same
WO2008134493A1 (en) 2007-04-25 2008-11-06 Boston Scientific Scimed, Inc. Medical devices for releasing therapeutic agent and methods of making the same
DE102007019703A1 (de) 2007-04-26 2008-10-30 Biotronik Vi Patent Ag Stent
US7888719B2 (en) 2007-05-23 2011-02-15 Taiwan Semiconductor Manufacturing Co., Ltd. Semiconductor memory structures
US7976915B2 (en) 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
DE602007009369D1 (de) 2007-05-28 2010-11-04 Acrostak Corp Bvi Magnesiumbasierte Legierungen
US20080306584A1 (en) 2007-06-05 2008-12-11 Pamela Kramer-Brown Implantable medical devices for local and regional treatment
US7632305B2 (en) * 2007-07-06 2009-12-15 Boston Scientific Scimed, Inc. Biodegradable connectors
US8002823B2 (en) * 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7942926B2 (en) * 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
DE102007032686A1 (de) * 2007-07-13 2009-01-15 Biotronik Vi Patent Ag Stent mit einer Beschichtung
US8205317B2 (en) * 2007-07-16 2012-06-26 Medtronic Vascular, Inc. Method of manufacturing a controlled porosity stent
US9284409B2 (en) 2007-07-19 2016-03-15 Boston Scientific Scimed, Inc. Endoprosthesis having a non-fouling surface
DE102007034041A1 (de) * 2007-07-20 2009-01-22 Biotronik Vi Patent Ag Medikamentendepots für medizinische Implantate
US20090024209A1 (en) * 2007-07-20 2009-01-22 Medtronic Vascular, Inc. Hypotubes for Intravascular Drug Delivery
DE102007034019A1 (de) * 2007-07-20 2009-01-22 Biotronik Vi Patent Ag Stent mit einer Beschichtung oder Füllung einer Kavität
US20090035351A1 (en) 2007-07-20 2009-02-05 Medtronic Vascular, Inc. Bioabsorbable Hypotubes for Intravascular Drug Delivery
US20090028785A1 (en) * 2007-07-23 2009-01-29 Boston Scientific Scimed, Inc. Medical devices with coatings for delivery of a therapeutic agent
DE102007034363A1 (de) * 2007-07-24 2009-01-29 Biotronik Vi Patent Ag Endoprothese
DE102007034364A1 (de) * 2007-07-24 2009-01-29 Biotronik Vi Patent Ag Degradierbarer Metallstent mit wirkstoffhaltiger Beschichtung
US20090157172A1 (en) 2007-07-24 2009-06-18 Boston Scientific Scrimed, Inc. Stents with polymer-free coatings for delivering a therapeutic agent
US20090030504A1 (en) * 2007-07-27 2009-01-29 Boston Scientific Scimed, Inc. Medical devices comprising porous inorganic fibers for the release of therapeutic agents
US20090030500A1 (en) * 2007-07-27 2009-01-29 Jan Weber Iron Ion Releasing Endoprostheses
US20090043330A1 (en) 2007-08-09 2009-02-12 Specialized Vascular Technologies, Inc. Embolic protection devices and methods
US20090043380A1 (en) 2007-08-09 2009-02-12 Specialized Vascular Technologies, Inc. Coatings for promoting endothelization of medical devices
DE102007038799A1 (de) 2007-08-17 2009-02-19 Biotronik Vi Patent Ag Implantat aus einer biokorrodierbaren Magnesiumlegierung und mit einer Beschichtung aus einem biokorrodierbaren Polyphosphazen
DE102007042451A1 (de) 2007-09-06 2009-03-12 Biotronik Vi Patent Ag Stent mit einem Grundkörper aus einer biokorrodierbaren Legierung
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
DE102007043883A1 (de) 2007-09-14 2009-03-26 Biotronik Vi Patent Ag Stent mit einer Beschichtung
US9173890B2 (en) 2007-09-20 2015-11-03 Abbott Cardiovascular Systems Inc. Sustained release of Apo A-I mimetic peptides and methods of treatment
JP2009082353A (ja) 2007-09-28 2009-04-23 Terumo Corp 生体内留置用ステントおよび生体器官拡張器具
US8998978B2 (en) 2007-09-28 2015-04-07 Abbott Cardiovascular Systems Inc. Stent formed from bioerodible metal-bioceramic composite
US20090093871A1 (en) 2007-10-08 2009-04-09 Medtronic Vascular, Inc. Medical Implant With Internal Drug Delivery System
US20090287302A1 (en) 2008-05-16 2009-11-19 Chameleon Scientific Corporation Polymer coated spinulose metal surfaces
US20090118821A1 (en) 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Endoprosthesis with porous reservoir and non-polymer diffusion layer
US20090118812A1 (en) 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Endoprosthesis coating
US20090118818A1 (en) 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Endoprosthesis with coating
ATE555819T1 (de) 2007-11-02 2012-05-15 Boston Scient Ltd Abbaubare endoprothese
US8029554B2 (en) 2007-11-02 2011-10-04 Boston Scientific Scimed, Inc. Stent with embedded material
US20090118813A1 (en) 2007-11-02 2009-05-07 Torsten Scheuermann Nano-patterned implant surfaces
US20090118809A1 (en) 2007-11-02 2009-05-07 Torsten Scheuermann Endoprosthesis with porous reservoir and non-polymer diffusion layer
US20090118823A1 (en) 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Endoprosthesis with porous reservoir
US20090118815A1 (en) 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Stent
US7938855B2 (en) 2007-11-02 2011-05-10 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
US20090143855A1 (en) 2007-11-29 2009-06-04 Boston Scientific Scimed, Inc. Medical Device Including Drug-Loaded Fibers
EP2067494A1 (en) 2007-12-04 2009-06-10 Charité-Universitätsmedizin Berlin Sheet or tubular structure consisting of elastic biocompatible material and its use
US20100008970A1 (en) * 2007-12-14 2010-01-14 Boston Scientific Scimed, Inc. Drug-Eluting Endoprosthesis
DE102007061647A1 (de) 2007-12-20 2009-07-02 Biotronik Vi Patent Ag Implantat mit einem Grundkörper aus einer biokorrodierbaren Legierung
US8317857B2 (en) * 2008-01-10 2012-11-27 Telesis Research, Llc Biodegradable self-expanding prosthesis
DE102008006455A1 (de) 2008-01-29 2009-07-30 Biotronik Vi Patent Ag Implantat mit einem Grundkörper aus einer biokorrodierbaren Legierung und einer korrosionshemmenden Beschichtung
JP2009178293A (ja) 2008-01-30 2009-08-13 Terumo Corp 医療用インプラント
DE102008006654A1 (de) 2008-01-30 2009-08-06 Biotronik Vi Patent Ag Implantat mit einem Grundkörper aus einer biokorrodierbaren Legierung
US20090196899A1 (en) 2008-01-31 2009-08-06 Medtronic Vascular, Inc. Controlled Alloy Stent
DE102008002601A1 (de) 2008-02-05 2009-08-06 Biotronik Vi Patent Ag Implantat mit einem Grundkörper aus einer biokorrodierbaren Eisenlegierung
US20090204203A1 (en) 2008-02-07 2009-08-13 Medtronic Vascular, Inc. Bioabsorbable Stent Having a Radiopaque Marker
WO2009102787A2 (en) 2008-02-12 2009-08-20 Boston Scientific Scimed, Inc. Medical implants with polysaccharide drug eluting coatings
EP2254605A4 (en) 2008-02-22 2012-06-20 Celonova Biosciences Inc MULTIFUNCTIONAL MATRICES FOR DRESSINGS AND ASSOCIATED METHODS
US20100042206A1 (en) 2008-03-04 2010-02-18 Icon Medical Corp. Bioabsorbable coatings for medical devices
US20090228037A1 (en) 2008-03-07 2009-09-10 Medtronic Vascular, Inc Vascular Closure Implant
US20090240323A1 (en) 2008-03-20 2009-09-24 Medtronic Vascular, Inc. Controlled Degradation of Magnesium Stents
WO2009126766A2 (en) 2008-04-10 2009-10-15 Boston Scientific Scimed, Inc. Medical devices with an interlocking coating and methods of making the same
DE102008020415A1 (de) 2008-04-24 2009-10-29 Biotronik Vi Patent Ag Biodegradierbare metallische Stents mit Wachsschicht
DE102008021894A1 (de) 2008-05-02 2009-11-05 Biotronik Vi Patent Ag Implantat umfassend eine Oberfläche mit verringerter Thrombogenität
US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
US20090287301A1 (en) 2008-05-16 2009-11-19 Boston Scientific, Scimed Inc. Coating for medical implants
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
JP2011524209A (ja) 2008-06-13 2011-09-01 ピボット・メディカル，インコーポレーテッド 関節伸延のための方法および装置
DE102008002471A1 (de) 2008-06-17 2009-12-24 Biotronik Vi Patent Ag Stent mit einer Beschichtung oder einem Grundkörper, der ein Lithiumsalz enthält, und Verwendung von Lithiumsalzen zur Restenoseprophylaxe
US8114148B2 (en) 2008-06-25 2012-02-14 Boston Scientific Scimed, Inc. Medical devices for delivery of therapeutic agent in conjunction with galvanic corrosion
EP2307068A2 (en) 2008-06-25 2011-04-13 Boston Scientific Scimed, Inc. Medical devices having surface coatings
DE102008040253A1 (de) * 2008-07-08 2010-01-14 Biotronik Vi Patent Ag Implantatsystem mit einem Funktionsimplantat aus abbaubarem Metallmaterial
DE102008040356A1 (de) * 2008-07-11 2010-01-14 Biotronik Vi Patent Ag Stent mit biodegradierbaren Stentstreben und Wirkstoffdepots
US8361139B2 (en) * 2008-07-16 2013-01-29 Boston Scientific Scimed, Inc. Medical devices having metal coatings for controlled drug release
EP2318063B1 (en) * 2008-07-23 2017-03-01 Boston Scientific Scimed, Inc. Medical devices having inorganic barrier coatings
DE102008040787A1 (de) * 2008-07-28 2010-02-04 Biotronik Vi Patent Ag Biokorrodierbares Implantat mit einer Beschichtung enthaltend ein Hydrogel
DE102008040786A1 (de) * 2008-07-28 2010-02-04 Biotronik Vi Patent Ag Biokorrodierbares Implantat mit einer Beschichtung enthaltend eine wirkstofftragende Polymermatrix
US7985252B2 (en) 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
EP2323709A2 (en) 2008-08-14 2011-05-25 Boston Scientific Scimed, Inc. Medical devices having electrodeposited conductive polymer coatings
DE102008038368A1 (de) 2008-08-19 2010-02-25 Biotronik Vi Patent Ag Verwendung von organischen Gold-Komplexen als bioaktive und radioopaque Stentbeschichtung für permanente und degradierbare vaskuläre Implantate
DE102008038367A1 (de) 2008-08-19 2010-02-25 Biotronik Vi Patent Ag Stent und Verfahren und Vorrichtung zur Herstellung des Stents
US8642063B2 (en) 2008-08-22 2014-02-04 Cook Medical Technologies Llc Implantable medical device coatings with biodegradable elastomer and releasable taxane agent
EP2320964A2 (en) 2008-08-27 2011-05-18 Boston Scientific Scimed, Inc. Medical devices having inorganic coatings for therapeutic agent delivery
US8337878B2 (en) 2008-08-27 2012-12-25 Boston Scientific Scimed, Inc. Medical devices having coatings for therapeutic agent delivery
US20100057188A1 (en) 2008-08-28 2010-03-04 Boston Scientific Scimed, Inc. Endoprostheses with porous regions and non-polymeric coating
US9119906B2 (en) 2008-09-24 2015-09-01 Integran Technologies, Inc. In-vivo biodegradable medical implant
DE602008006079D1 (de) 2008-09-30 2011-05-19 Biotronik Vi Patent Ag Implantat aus einer biologisch abbaubaren Magnesiumlegierung
DE102008042578A1 (de) 2008-10-02 2010-04-08 Biotronik Vi Patent Ag Implantat mit einem Grundkörper aus einer biokorrodierbaren Manganlegierung
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
DE102008042603A1 (de) 2008-10-06 2010-04-08 Biotronik Vi Patent Ag Implantat sowie Verfahren zur Herstellung einer degradationshemmenden Schicht auf einer Körperoberfläche eines Implantats
EP2179752B1 (de) 2008-10-06 2014-08-13 Biotronik VI Patent AG Implantat sowie Verfahren zur Herstellung desselben
DE102009002709A1 (de) 2008-10-06 2010-04-08 Biotronik Vi Patent Ag Implantat und Verfahren zur Herstellung desselben
US20100092535A1 (en) 2008-10-10 2010-04-15 Medtronic Vascular, Inc. Nanoporous Drug Delivery System
DE102008043277A1 (de) 2008-10-29 2010-05-06 Biotronik Vi Patent Ag Implantat aus einer biokorrodierbaren Eisen- oder Magnesiumlegierung
DE102008043642A1 (de) 2008-11-11 2010-05-12 Biotronik Vi Patent Ag Endoprothese
DE102008043724A1 (de) 2008-11-13 2010-05-20 Biotronik Vi Patent Ag Erhöhung der Effizienz pharmazeutische Wirkstoffe-freisetzender Medizinprodukte durch Kombination mit einem Inhibitor des Transportproteins P-Glycoprotein
US20100125325A1 (en) 2008-11-20 2010-05-20 Medtronic Vascular, Inc. Stent With Cathodic Protection and Stent Delivery System
DE102008043970A1 (de) 2008-11-21 2010-05-27 Biotronik Vi Patent Ag Verfahren zur Herstellung einer korrosionshemmenden Beschichtung auf einem Implantat aus einer biokorrodierbaren Magnesiumlegierung sowie nach dem Verfahren hergestelltes Implantat
US9283304B2 (en) 2008-11-25 2016-03-15 CARDINAL HEALTH SWITZERLAND 515 GmbH Absorbable stent having a coating for controlling degradation of the stent and maintaining pH neutrality
US20100217370A1 (en) 2009-02-20 2010-08-26 Boston Scientific Scimed, Inc. Bioerodible Endoprosthesis

Also Published As

Publication number Publication date
US8002821B2 (en) 2011-08-23
WO2008036548A3 (en) 2008-05-22
CA2663762A1 (en) 2008-03-27
US20080071350A1 (en) 2008-03-20
WO2008036548A2 (en) 2008-03-27
EP2068962B1 (en) 2013-01-30
EP2068962A2 (en) 2009-06-17

Similar Documents

Publication Publication Date Title
JP2010503482A (ja) 内部人工器官
JP2010503486A (ja) 内部人工器官
JP2010503483A (ja) 医療装置
JP5355418B2 (ja) 生侵食性内部人工器官、及び該生侵食性内部人工器官を製造する方法
JP5204666B2 (ja) 生体侵食性体内プロテーゼ、およびその製造方法
US20080071357A1 (en) Controlling biodegradation of a medical instrument
JP5572686B2 (ja) 分解性の移植可能な医療装置
US20080082162A1 (en) Bioerodible endoprostheses and methods of making the same
US20100145436A1 (en) Bio-erodible Stent
JP2017094016A (ja) 生体吸収性医療器具及びその分解速度調整方法

Legal Events

Date Code Title Description
A300 Application deemed to be withdrawn because no request for examination was validly filed

Free format text: JAPANESE INTERMEDIATE CODE: A300

Effective date: 20101207