JP2010280734A - リパーゼ阻害活性且つ抗酸化性を有する抗肥満剤 - Google Patents
リパーゼ阻害活性且つ抗酸化性を有する抗肥満剤 Download PDFInfo
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- JP2010280734A JP2010280734A JP2010214899A JP2010214899A JP2010280734A JP 2010280734 A JP2010280734 A JP 2010280734A JP 2010214899 A JP2010214899 A JP 2010214899A JP 2010214899 A JP2010214899 A JP 2010214899A JP 2010280734 A JP2010280734 A JP 2010280734A
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- lipase
- antioxidant
- obesity
- inhibitory activity
- lipase inhibitory
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Abstract
【解決手段】イタドリ、インゲンマメ、オオゴチョウ、オオフトモモ、ガジュマル、ゲットウ、サキシマスオウノキ、セイロンベンケイ、タカサゴギク、ナンテン、ベニバナ、モクセンナ、モモタマナおよびリュウキュウマツからなる群から選ばれた少なくとも1種類以上の生物素材の抽出物を用いることでリパーゼ阻害活性または抗酸化性成分を含有する抗肥満剤、リパーゼ阻害剤、抗酸化剤、化粧品を提供する。
【選択図】なし
Description
脂肪は食品成分の中で最も高カロリーであり、脂質蓄積量が肥満の予防に効果的と考えられている。リパーゼは摂取された脂質の分解に関与する消化酵素であり、ヒトにおいては膵臓から分泌される。リパーゼにより、中性脂肪、すなわちトリグリセリド(トリアシルグリセロールのエステル結合)は順次加水分解を受け、ジアシルグリセロール、モノアシルグリセロールを経てグリセロールと脂肪酸が生ずる。脂質の過剰摂取は、これらの栄養成分が過剰に小腸より吸収されるため、肥満や高脂血症を誘発する。そのため、リパーゼを阻害または抑制することは、血清脂質を低下し、体内への脂質の蓄積を抑え、肥満の抑制および予防に大きく寄与すると考えられる。
皮膚上に分泌される皮脂は、紫外線などにより酸化され過酸化脂質となり、皮膚に対するしわやシミ等の障害や老化促進となる。従って、過酸化脂質の生成を抑制することは、肌(皮膚)の状態の悪化防止のみならず、生体自体の老化防止に有効であると考えられる。
1.リパーゼ阻害活性と抗酸化性を有する素材や成分であること。
2.更に両活性が同時に機能するような条件を定めること。
3.安全性の点で満足できるものであること。
本発明の抗酸化性且つリパーゼ阻害活性を有する抗肥満剤は、化学合成薬剤に比べて効き目が穏やかであり、また自然界から、亜熱帯地域や沖縄で古くから用いられてきた天然起源の伝統食材や薬用として用いられている生物資源の抽出物のため安全性が高い。更に、抗酸化性とリパーゼ阻害活性が同時に機能するような乾燥および抽出条件を定めたことで、肥満予防やニキビ予防はもとより、生体内の酸化的ストレスを軽減させ、その結果、皮膚のシミ・そばかす、更には悪性新生物(ガン)等の病因ともなるリスクを軽減させる安全な製剤、化粧品を提供することができる。したがって、生活習慣病や悪性新生物などの疾病の予防・遅延に極めて有効である。
各植物を適当な大きさに切断した後、65℃12時間の温風乾燥若しくは、凍結乾燥後、破砕し0.5mmのメッシュを通過したものを生物素材ごとに抽出操作に供した。抽出操作は、高圧抽出を使用した。すなわち、乾燥重量で0.5g〜5gの各薬草乾燥粉末を5gのケイソウ土とともに抽出セルに添加し、抽出溶媒;50%エタノール、溶媒量;25ml、抽出温度;82℃、抽出圧力;13.8MPa、抽出時間;10分、抽出回数;2回の条件で抽出操作を行った。抽出液は0.45μmのメンブレンフィルターでろ過した。
リパーゼ阻害活性試験は、大日本製薬社製リパーゼキットSを用いた。酵素液は、ラット腸管アセトンパウダー10gに0.1Mクエン酸緩衝液(pH6.0)100mlを添加し、氷中で1時間撹拌した後、4℃、15,000rpm.で45分間遠心分離し、上清をクエン酸緩衝液で100倍に希釈して調製した。測定試料10μlに、0.1mg/mlの5,5-ジオビス(2-ニトロ安息香酸)を含む発色液237μl、酵素液9μl、エステラーゼ阻害剤(3.48mg/ml フェニルメチルスルホニルフルオリド)4μlを添加し5分間、30℃でプレインキュベート後、基質液(6.69mg/ml 三酪酸ジメルカプロールおよび5.73mg/mlドデシル硫酸ナトリウムを含む)25μlを添加して、遮光下30℃で30分反応を行った。反応停止液500μlを添加後、405nmの吸光度を測定した(試料溶液)。コントロールは、試料抽出液である50%エタノールを添加してリパーゼ活性を測定した(コントロール溶液)。ブランクは、試料溶液または50%エタノール溶液、発色液、粗酵素液、エステラーゼ阻害剤を添加して30分間反応させ、反応停止液、基質液を順次添加した。なお、リパーゼ阻害活性は次式を用いて計算した。
リパーゼ阻害率=100−(試料の吸光度−試料のブランク吸光度)/(コントロールの吸光度−コントロールのブランク吸光度)x100
抗酸化性はDPPH(1,1−diphenyl−2−picrylhydrazyl)に対する被検液のラジカル消去能を市場らの方法に(市場、喜屋武、沖工技セ研究報告第1号、pp.9−22、(1998))より測定した。すなわち、1.5mMのDPPHをエタノールに溶解し、蒸留水で2倍に希釈して0.75mM DPPH溶液を調製した。次にマイクロプレートの各wellに約1.5〜1093(倍)の希釈倍率をもうけた被検液100μlを添加し、更に50μlのDPPH溶液を添加・混合して20分後の515nmの吸光度を測定した。被検液の代わりに50%エタノールを添加した場合の吸光度を100%として、吸光度50%に相当する希釈倍率を求めIC50とした。すなわち、縦軸にDPPHラジカルの消去量(%)、横軸に被検液の希釈倍率をとった場合の、被検液のDPPHラジカル消去能の濃度依存曲線より、125μMのDPPHラジカルを消去する被検液の希釈倍率(IC50)を求めた。
(組成) (重量部)
マーガリン 30
砂糖 16
食塩 0.003
全卵 8.6
薄力粉 43.897
ガジュマル抽出物 3.5
Claims (3)
- リパーゼ阻害活性を有するイタドリ、サキシマスオウノキ、タカサゴギク、インゲンマメ、ゲットウ、ナンテン、ベニバナ、オオフトモモ、セイロンベンケイ、ガジュマル、モモタマナ、モクセンナ、オオゴチョウ、リュウキュウマツからなる群から選ばれた少なくとも1種類以上の植物からの、ケイソウ土を添加し、70〜90℃の抽出温度で、50%エタノールにより得た抽出物を、含有するリパーゼ阻害剤。
- 抗酸化活性を有するイタドリ、サキシマスオウノキ、タカサゴギクからなる群から選ばれた少なくとも1種類以上の植物からの、ケイソウ土を添加し、70〜90℃の抽出温度で、50%エタノールにより得た抽出物を、含有する抗酸化剤。
- インゲンマメの種皮の、ケイソウ土を添加し、70〜90℃の抽出温度で、50%エタノールにより得た抽出物を、含有するリパーゼ阻害剤。
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102949456A (zh) * | 2011-08-30 | 2013-03-06 | 江守训 | 小叶榕萃取物的制备方法及促进伤口愈合的药物或伤口包扎物 |
WO2013116138A1 (en) * | 2012-01-30 | 2013-08-08 | Access Business Group International Llc | Anti-inflammatory and antioxidant composition and related method of use |
FR3000390A1 (fr) * | 2012-12-28 | 2014-07-04 | Clarins Lab | Composition cosmetique comprenant un extrait de kalanchoe pinnata |
CN104906163A (zh) * | 2015-06-09 | 2015-09-16 | 中国科学院西北高原生物研究所 | 黄刺果实及其提取物降血糖的用途 |
CN104922215A (zh) * | 2014-03-19 | 2015-09-23 | 黎永荣 | 一种中药药方 |
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Non-Patent Citations (1)
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JPN6012055949; Tsuda,Takanori et al: 'Antioxidative pigments isolated from the seeds of Phaseolus vulgaris L.' Journal of Agricultural and Food Chemistry Vol.42,No.2, 1994, pp.248-251 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102949456A (zh) * | 2011-08-30 | 2013-03-06 | 江守训 | 小叶榕萃取物的制备方法及促进伤口愈合的药物或伤口包扎物 |
WO2013116138A1 (en) * | 2012-01-30 | 2013-08-08 | Access Business Group International Llc | Anti-inflammatory and antioxidant composition and related method of use |
CN104066434A (zh) * | 2012-01-30 | 2014-09-24 | 捷通国际有限公司 | 抗炎和抗氧化组合物和相关使用方法 |
FR3000390A1 (fr) * | 2012-12-28 | 2014-07-04 | Clarins Lab | Composition cosmetique comprenant un extrait de kalanchoe pinnata |
CN104922215A (zh) * | 2014-03-19 | 2015-09-23 | 黎永荣 | 一种中药药方 |
CN104906163A (zh) * | 2015-06-09 | 2015-09-16 | 中国科学院西北高原生物研究所 | 黄刺果实及其提取物降血糖的用途 |
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