JP2010126754A - Pretreatment agent for drying of cleaned medical appliance, and method for regenerating used medical appliance - Google Patents
Pretreatment agent for drying of cleaned medical appliance, and method for regenerating used medical appliance Download PDFInfo
- Publication number
- JP2010126754A JP2010126754A JP2008301450A JP2008301450A JP2010126754A JP 2010126754 A JP2010126754 A JP 2010126754A JP 2008301450 A JP2008301450 A JP 2008301450A JP 2008301450 A JP2008301450 A JP 2008301450A JP 2010126754 A JP2010126754 A JP 2010126754A
- Authority
- JP
- Japan
- Prior art keywords
- drying
- surfactant
- agent
- pretreatment agent
- medical device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000001035 drying Methods 0.000 title claims abstract description 152
- 238000000034 method Methods 0.000 title claims description 16
- 230000001172 regenerating effect Effects 0.000 title description 4
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 82
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 78
- 239000004094 surface-active agent Substances 0.000 claims abstract description 70
- 238000004140 cleaning Methods 0.000 claims abstract description 18
- 239000002904 solvent Substances 0.000 claims abstract description 16
- 239000004480 active ingredient Substances 0.000 claims abstract description 8
- 239000007864 aqueous solution Substances 0.000 claims abstract description 5
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 54
- 238000010790 dilution Methods 0.000 claims description 50
- 239000012895 dilution Substances 0.000 claims description 50
- -1 glycerin fatty acid ester Chemical class 0.000 claims description 45
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 40
- 229930195729 fatty acid Natural products 0.000 claims description 40
- 239000000194 fatty acid Substances 0.000 claims description 40
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 29
- 230000003449 preventive effect Effects 0.000 claims description 28
- LKUNXBRZDFMZOK-GFCCVEGCSA-N Capric acid monoglyceride Natural products CCCCCCCCCC(=O)OC[C@H](O)CO LKUNXBRZDFMZOK-GFCCVEGCSA-N 0.000 claims description 20
- GHBFNMLVSPCDGN-UHFFFAOYSA-N rac-1-monooctanoylglycerol Chemical compound CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 claims description 20
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 15
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 13
- 239000003112 inhibitor Substances 0.000 claims description 12
- 235000011187 glycerol Nutrition 0.000 claims description 11
- 230000008929 regeneration Effects 0.000 claims description 10
- 238000011069 regeneration method Methods 0.000 claims description 10
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 9
- 238000005406 washing Methods 0.000 claims description 9
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 8
- 239000000787 lecithin Substances 0.000 claims description 8
- 229940067606 lecithin Drugs 0.000 claims description 8
- 235000010445 lecithin Nutrition 0.000 claims description 8
- 239000004475 Arginine Substances 0.000 claims description 7
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 7
- 108010039918 Polylysine Proteins 0.000 claims description 6
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 6
- 229930006000 Sucrose Natural products 0.000 claims description 6
- 239000005720 sucrose Substances 0.000 claims description 6
- 150000001413 amino acids Chemical class 0.000 claims description 5
- 150000007524 organic acids Chemical class 0.000 claims description 5
- 229920000656 polylysine Polymers 0.000 claims description 5
- 239000005711 Benzoic acid Substances 0.000 claims description 4
- 235000010233 benzoic acid Nutrition 0.000 claims description 4
- 229920001184 polypeptide Polymers 0.000 claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
- 108010062796 arginyllysine Proteins 0.000 claims description 2
- 235000005985 organic acids Nutrition 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 43
- 239000000243 solution Substances 0.000 abstract description 22
- 230000001050 lubricating effect Effects 0.000 abstract description 14
- 239000013556 antirust agent Substances 0.000 abstract description 3
- 239000011550 stock solution Substances 0.000 description 23
- 239000007788 liquid Substances 0.000 description 19
- 230000001133 acceleration Effects 0.000 description 15
- 230000002265 prevention Effects 0.000 description 12
- 238000007865 diluting Methods 0.000 description 8
- 238000007598 dipping method Methods 0.000 description 8
- 235000013373 food additive Nutrition 0.000 description 8
- 239000002778 food additive Substances 0.000 description 8
- 238000005461 lubrication Methods 0.000 description 8
- 238000012545 processing Methods 0.000 description 8
- 229910001220 stainless steel Inorganic materials 0.000 description 8
- 239000010935 stainless steel Substances 0.000 description 8
- 238000005187 foaming Methods 0.000 description 7
- 230000008569 process Effects 0.000 description 7
- 230000009471 action Effects 0.000 description 6
- 235000009697 arginine Nutrition 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- 238000011156 evaluation Methods 0.000 description 6
- 230000009467 reduction Effects 0.000 description 6
- 238000000926 separation method Methods 0.000 description 6
- 230000008859 change Effects 0.000 description 5
- 238000002845 discoloration Methods 0.000 description 5
- 229940057995 liquid paraffin Drugs 0.000 description 5
- 239000007921 spray Substances 0.000 description 5
- 238000004659 sterilization and disinfection Methods 0.000 description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 229910000831 Steel Inorganic materials 0.000 description 4
- 235000001014 amino acid Nutrition 0.000 description 4
- 229940024606 amino acid Drugs 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 235000013772 propylene glycol Nutrition 0.000 description 4
- 238000004904 shortening Methods 0.000 description 4
- 239000004299 sodium benzoate Substances 0.000 description 4
- 235000010234 sodium benzoate Nutrition 0.000 description 4
- 239000010959 steel Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000002274 desiccant Substances 0.000 description 3
- 238000004945 emulsification Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000002736 nonionic surfactant Substances 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 238000003672 processing method Methods 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- GCSPRLPXTPMSTL-IBDNADADSA-N [(2s,3r,4s,5s,6r)-2-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)O[C@@]1([C@]2(CO)[C@H]([C@H](O)[C@@H](CO)O2)O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GCSPRLPXTPMSTL-IBDNADADSA-N 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 235000019441 ethanol Nutrition 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 239000010687 lubricating oil Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000008237 rinsing water Substances 0.000 description 2
- 238000011076 safety test Methods 0.000 description 2
- 230000003381 solubilizing effect Effects 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 239000008399 tap water Substances 0.000 description 2
- 235000020679 tap water Nutrition 0.000 description 2
- 150000003626 triacylglycerols Chemical class 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- HFEMPWKWYHWPQX-UHFFFAOYSA-N 2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid;hydrochloride Chemical compound Cl.IC1=CC(CC(N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 HFEMPWKWYHWPQX-UHFFFAOYSA-N 0.000 description 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N Caprylic acid Natural products CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 1
- GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Natural products CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- DHCKZQAOKLTFLJ-UHFFFAOYSA-N OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.CCCCCCCC(O)=O Chemical compound OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.CCCCCCCC(O)=O DHCKZQAOKLTFLJ-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 241000219289 Silene Species 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- WYTGDNHDOZPMIW-RCBQFDQVSA-N alstonine Natural products C1=CC2=C3C=CC=CC3=NC2=C2N1C[C@H]1[C@H](C)OC=C(C(=O)OC)[C@H]1C2 WYTGDNHDOZPMIW-RCBQFDQVSA-N 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 235000009582 asparagine Nutrition 0.000 description 1
- 229960001230 asparagine Drugs 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 239000010696 ester oil Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 235000004554 glutamine Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 235000014304 histidine Nutrition 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 235000018977 lysine Nutrition 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 description 1
- 229960002446 octanoic acid Drugs 0.000 description 1
- KTYWLVRJVNKZJD-UHFFFAOYSA-N octanoic acid propane-1,2,3-triol Chemical compound OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.CCCCCCCC(O)=O KTYWLVRJVNKZJD-UHFFFAOYSA-N 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 229960003656 ricinoleic acid Drugs 0.000 description 1
- FEUQNCSVHBHROZ-UHFFFAOYSA-N ricinoleic acid Natural products CCCCCCC(O[Si](C)(C)C)CC=CCCCCCCCC(=O)OC FEUQNCSVHBHROZ-UHFFFAOYSA-N 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Images
Landscapes
- Preventing Corrosion Or Incrustation Of Metals (AREA)
- Cleaning By Liquid Or Steam (AREA)
Abstract
Description
本発明は、反復利用する医療器具を使用後、洗浄・濯ぎを行って乾燥して再生させる際に、その乾燥前の医療器具に施す乾燥前処理剤と、この乾燥前処理剤を用いた使用済み医療器具の再生方法に関する。 The present invention relates to a pre-drying treatment agent applied to a medical device before drying when the medical device to be repeatedly used is used for washing and rinsing, drying and regenerating, and use using this pre-drying treatment agent The present invention relates to a method for recycling used medical devices.
医療機関において手術等の医療行為や医療処置に使用する器具として、使用後に再生処理を施して繰り返し使用するものが多々ある。その再生処理は、洗浄、濯ぎ、乾燥、滅菌・消毒の各工程を順次経るのが一般的であるが、殺菌消毒剤入り洗浄液を用いて洗浄と同時に滅菌・消毒を行う場合もある。 Many instruments used in medical institutions for medical procedures such as surgery and medical procedures are repeatedly used after being subjected to regeneration treatment. In general, the regeneration process includes steps of washing, rinsing, drying, sterilization / disinfection in sequence. However, there are cases where sterilization / disinfection is performed simultaneously with washing using a cleaning solution containing a disinfectant.
しかるに、このような再生処理において、最終濯ぎを水道水のような何も添加しない水だけで行うと、次の乾燥に時間を要して処理能率が悪くなると共に、消費エネルギーの増大で処理コストも高く付く上、乾燥後の器具表面に水由来の硬度成分の析出によるウォータースポットが発生するという難点があった。特に、呼吸器等に使用する蛇管は、鋼製小物と同様の再生処理を行うが、最終濯ぎを水だけで行うと、構造的に凹部に水が残留し易く、乾燥後のウォータースポットが目立つことに加え、耐熱性に乏しいために60℃程度の低い温度での長時間の乾燥を余儀なくされている。また、鉗子や鋏のような可動部を有する金属製器具では、前記硬度成分の蓄積と表面滑性の喪失によって可動部の動きが悪くなって使いづらくなると共に、金属同士が擦れ合って摩耗し、その摩耗部分に水分や汚れが着き易くなって腐食に繋がるという問題があった。更に、複雑な構造の器具では、上記濯ぎによって隙間等に水分が溜まり易く、次の乾燥工程で乾くまでに水分との接触時間が長くなって発錆し易くなる。 However, in such a regeneration process, if final rinsing is performed only with water to which nothing is added, such as tap water, it takes time for the next drying, and the processing efficiency deteriorates and the processing cost increases due to the increase in energy consumption. Further, there is a problem that a water spot is generated due to precipitation of a hardness component derived from water on the surface of the instrument after drying. In particular, the serpentine tube used for a respirator or the like performs the same regeneration treatment as a steel accessory, but if the final rinse is performed only with water, the water tends to remain in the recess structurally, and the water spot after drying is conspicuous. In addition, since it has poor heat resistance, it must be dried for a long time at a low temperature of about 60 ° C. In addition, in metal instruments having movable parts such as forceps and scissors, the movement of the movable parts becomes difficult due to the accumulation of the hardness component and the loss of surface lubricity, and the metal parts rub against each other and wear. There is a problem that moisture and dirt are easily attached to the worn part, which leads to corrosion. Furthermore, in a device having a complicated structure, moisture easily accumulates in gaps and the like due to the rinsing, and the contact time with moisture becomes long before drying in the next drying step, and rusting is likely to occur.
そこで、従来では、乾燥前の最終濯ぎ工程において、潤滑防錆剤として流動パラフィンの如き鉱物油や植物系のエステル油を非イオン界面活性剤で乳化したものを濯ぎ水に加えて用いたり(特許文献1)、乾燥促進剤としてエタノール等のアルコールに非イオン界面活性剤を少量加えた製剤をそのまま原液で使用する(特許文献2)ことが提案されている。
しかしながら、上記乳化型の潤滑防錆剤を用いた場合、潤滑性や防錆性は付与されるが、乾燥時間は僅かに短縮されるだけである上、使用時の希釈による濃度変化や乾燥時の温度変化によって油分が合一・分離し、器具表面に該油分によるシミを生じ易いため、清浄度が要求される医療器具では目視判定で洗浄不良と判定される懸念がある。また、最終濯ぎに用いた潤滑防錆剤は当然に器具表面に残留するが、潤滑油は可食性でないことに加え、その脂肪酸エステルのアルキル基がイソプロピル基やブチル基の場合に、分解して毒性の強いイソプロピルアルコールやブタノールを生成する懸念もあり、生体に触れる医療器具用としては安全性に問題がある。 However, when the above emulsifying type lubricating rust preventive agent is used, lubricity and rust preventive properties are imparted, but the drying time is only slightly shortened, and the concentration change due to dilution during use and when drying Due to the temperature change, the oil components are coalesced and separated, and stains due to the oil components are likely to occur on the surface of the device. Therefore, there is a concern that medical devices that require cleanliness are judged as poorly washed by visual judgment. In addition, the lubricating rust preventive used in the final rinsing will naturally remain on the surface of the appliance, but in addition to the fact that the lubricating oil is not edible, it will decompose when the alkyl group of the fatty acid ester is an isopropyl group or a butyl group. There is also a concern of producing highly toxic isopropyl alcohol and butanol, and there is a problem in safety for medical devices that come into contact with living bodies.
一方、前記の乾燥促進剤としてアルコールに非イオン界面活性剤を加えた製剤を原液で使用する方法では、高濃度のアルコールが水分と置換することで乾燥促進作用が得られると共に、アルコールによる消毒作用も期待できるが、原液使用のために処理コストが非常に高く付くという難点があった。 On the other hand, in the method of using a preparation in which a nonionic surfactant is added to alcohol as the drying accelerator in the stock solution, a high concentration of alcohol is replaced with moisture to obtain a drying acceleration action, and an alcohol disinfection action. However, there is a problem that the processing cost is very high due to the use of the stock solution.
本発明は、上述の事情に鑑みて、反復利用する医療器具の使用後、洗浄・濯ぎを行って乾燥して再生させる際に、その乾燥前の医療器具に施す乾燥前処理において、処理剤を水希釈によって極めて低濃度で用いても乾燥時間を大幅に短縮できると共に、従来のような乳化型の潤滑防錆剤を用いることなく優れた防錆効果及び潤滑効果を付与できる上、器具表面のウォータースポットやシミ等の生成を防止でき、且つ高い安全性を確保することが可能であり、また低濃度での使用によって処理コストを著しく低減できる手段を提供することを目的としている。 In view of the above-described circumstances, the present invention provides a treatment agent in a pre-drying treatment applied to a medical device before drying when the medical device to be repeatedly used is washed and rinsed, dried and regenerated. Even if it is used at a very low concentration by dilution with water, the drying time can be greatly shortened and an excellent antirust effect and lubrication effect can be imparted without using a conventional emulsifying type lubricating antirust agent. An object of the present invention is to provide a means that can prevent the generation of water spots, spots, etc., can ensure high safety, and can significantly reduce the processing cost by use at a low concentration.
上記目的を達成するために、本発明の請求項1に係る医療器具の乾燥前処理剤は、有機防錆剤と、界面活性剤と、該界面活性剤に対する可溶化剤とを有効成分として含有する水性溶液からなることを特徴としている。 In order to achieve the above object, a pretreatment drying pretreatment agent for a medical device according to claim 1 of the present invention contains an organic rust inhibitor, a surfactant, and a solubilizer for the surfactant as active ingredients. It is characterized by comprising an aqueous solution.
請求項2の発明は、請求項1の医療器具の乾燥前処理剤において、有機防錆剤0.1〜5質量%と、界面活性剤4〜60質量%と、可溶化剤1〜50質量%とを含有する水性溶液からなるものとしている。
The invention according to
請求項3の発明は、上記請求項2の医療器具の乾燥前処理剤において、界面活性剤濃度0.02%となる水希釈液のSUS410表面に対する滴下3分後の接触角が21°以下である構成としている。
According to the invention of claim 3, in the pretreatment agent for drying of the medical device of
請求項4の発明は、上記請求項1〜3の何れかの医療器具の乾燥前処理剤において、界面活性剤がグリセリン脂肪酸エステル、ソルビタン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ショ糖脂肪酸エステル、ポリオキシエチレンソルビタン脂肪酸エステル、プロピレングリコール脂肪酸エステル、レシチンより選ばれる少なくとも一種を主成分とするものとしている。 According to a fourth aspect of the present invention, in the pretreatment drying agent for a medical device according to any one of the first to third aspects, the surfactant is a glycerin fatty acid ester, sorbitan fatty acid ester, polyglycerin fatty acid ester, sucrose fatty acid ester, polyoxy The main component is at least one selected from ethylene sorbitan fatty acid ester, propylene glycol fatty acid ester, and lecithin.
請求項5の発明は、上記請求項1〜3の何れかの医療器具の乾燥前処理剤において、上記界面活性剤としてカプリン酸モノグリセリドを必須成分として含有する構成としている。 According to a fifth aspect of the present invention, in the medical treatment pre-drying agent according to any one of the first to third aspects, a capric acid monoglyceride is contained as an essential component as the surfactant.
請求項6の発明は、上記請求項1〜3の何れかの医療器具の乾燥前処理剤において、上記界面活性剤としてカプリン酸モノグリセリド及びカプリル酸モノグリセリドを前者:後者の重量比が1:0.5〜1.5となる割合で含有する請求項4に記載の洗浄医療器具の乾燥前処理剤。 According to a sixth aspect of the present invention, in the pretreatment agent for drying a medical device according to any one of the first to third aspects, capric acid monoglyceride and caprylic acid monoglyceride are used as the surfactant in the former: latter weight ratio of 1: 0. The pretreatment agent for drying medical cleaning device according to claim 4, which is contained in a ratio of 5 to 1.5.
請求項7の発明は、上記請求項1〜6のいずれかの医療器具の乾燥前処理剤において、有機防錆剤が有機酸又はその塩、アミノ酸、ポリペプチドより選ばれる少なくとも一種からなる構成としている。 The invention of claim 7 is the pretreatment drying pretreatment agent for the medical device according to any one of claims 1 to 6, wherein the organic rust inhibitor is composed of at least one selected from an organic acid or a salt thereof, an amino acid, and a polypeptide. Yes.
請求項8の発明は、上記請求項7の医療器具の乾燥前処理剤において、上記有機防錆剤が、安息香酸又はその塩、アルギニン、ポリリジンより選ばれる少なくとも一種からなる構成としている。 The invention according to claim 8 is the pretreatment drying pretreatment agent for the medical instrument according to claim 7, wherein the organic rust preventive is composed of at least one selected from benzoic acid or a salt thereof, arginine, and polylysine.
請求項9の発明は、上記請求項1〜8のいずれかの医療器具の乾燥前処理剤において、上記可溶化剤がエタノール、グリセリン、プロピレングリコールより選ばれる少なくとも一種からなる構成としている。 The invention of claim 9 is the pretreatment drying pretreatment agent for the medical device according to any one of claims 1 to 8, wherein the solubilizer comprises at least one selected from ethanol, glycerin and propylene glycol.
請求項10の発明に係る医療器具の再生処理方法は、使用済み医療器具に洗浄及び濯ぎを施したのち、該医療器具の表面に上記請求項1〜9の何れかに記載の乾燥前処理剤を水分量99質量%以上の水希釈液として付与し、次いで該医療器具の乾燥処理を行うことを特徴としている。
The medical device regeneration treatment method according to the invention of
請求項11の発明は、上記請求項10の医療器具の再生処理方法において、水希釈液を界面活性剤濃度0.02〜0.1質量%とすることを特徴としている。 An eleventh aspect of the invention is characterized in that, in the medical device regeneration processing method of the tenth aspect, the water dilution is adjusted to a surfactant concentration of 0.02 to 0.1 mass%.
請求項1の発明に係る乾燥前処理剤は、有機防錆剤と、界面活性剤と、該界面活性剤に対する可溶化剤とを有効成分として含有することから、反復利用する医療器具の使用後に洗浄・濯ぎを行って乾燥して再生させる際、その乾燥前の医療器具に対して極めて低濃度の水希釈液(一般的に水分量が99質量%以上)として用いることにより、乾燥時間を大幅に短縮して、且つ器具表面のウォータースポットやシミ等の生成を防止できる上、従来のような乳化型の潤滑防錆剤を含まずに高い防錆効果及び潤滑効果を付与できる。また、この乾燥前処理剤によれば、上記の極めて低濃度の水希釈液として使用することで処理コストが著しく低減されると共に、各有効成分として食品添加物に認可されたものを選択することで高い安全性を確保することが可能となる。 Since the drying pretreatment agent according to the invention of claim 1 contains an organic rust inhibitor, a surfactant, and a solubilizing agent for the surfactant as active ingredients, it is used after repeated use of a medical device. When drying and regenerating by washing and rinsing, use as an extremely low-concentration water diluting solution (generally the water content is 99% by mass or more) for the medical device before drying, greatly increasing the drying time. In addition to the generation of water spots and spots on the surface of the instrument, it is possible to provide a high rust prevention effect and lubrication effect without including an emulsification type lubricating rust preventive agent as in the prior art. In addition, according to this pre-drying treatment agent, the treatment cost is remarkably reduced by using it as the above-mentioned extremely low-concentration water diluting solution, and each active ingredient is approved as a food additive. Therefore, it is possible to ensure high safety.
請求項2の発明によれば、上記乾燥前処理剤の各有効成分を特定濃度範囲に設定することから、原液を低温下及び高温下のいずれでも長期間安定に保存でき、且つ使用時に極低濃度に水希釈しても優れた乾燥促進効果、防錆効果、潤滑効果が得られる。
According to the invention of
請求項3の発明に係る乾燥前処理剤は、含有する界面活性剤が0.02質量%になるまで水希釈した際の接触角が特定値以下となる性状を有するから、0.02質量%以上の濃度の水希釈液として用いることで良好な乾燥促進効果が得られる。 The drying pretreatment agent according to the invention of claim 3 has a property that the contact angle when diluted with water until the contained surfactant becomes 0.02% by mass is 0.02% by mass or less. A good drying accelerating effect can be obtained by using it as a water diluting solution having the above concentration.
請求項4の発明に係る乾燥前処理剤は、界面活性剤として特定成分を使用することから、高い安全性を確保しながら、良好な乾燥促進効果及び潤滑効果を付与できる。 Since the drying pretreatment agent according to the invention of claim 4 uses a specific component as a surfactant, it can impart a good drying accelerating effect and a lubricating effect while ensuring high safety.
請求項5の発明に係る乾燥前処理剤は、上記界面活性剤としてカプリン酸モノグリセリドを含有することから、特に良好な乾燥促進効果が得られる。
Since the drying pretreatment agent according to the invention of
請求項6の発明に係る乾燥前処理剤は、上記界面活性剤としてカプリン酸モノグリセリド及びカプリル酸モノグリセリドを特定比率で含有するから、良好な乾燥促進効果が得られると共に、使用時の水希釈液における泡立ちが少ないため、噴射洗浄機での使用に適するという利点がある。 Since the pretreatment agent for drying according to the invention of claim 6 contains capric acid monoglyceride and caprylic acid monoglyceride in a specific ratio as the surfactant, a good drying accelerating effect can be obtained, and in a water dilution at the time of use. Since there is little foaming, there exists an advantage that it is suitable for use with a jet cleaner.
請求項7の発明に係る乾燥前処理剤は、上記の有機防錆剤が特定成分からなるため、安全性を確保して且つステンレス鋼等の金属製の医療器具に対して良好な防錆効果を付与できる。 In the pre-drying treatment agent according to the invention of claim 7, since the organic rust preventive agent comprises a specific component, the safety is ensured and the rust preventive effect is good for a metal medical instrument such as stainless steel. Can be granted.
請求項8の発明に係る乾燥前処理剤は、有機防錆剤として用いる安息香酸又はその塩、アルギニン、ポリリジンがいずれも食品添加物に認可された安全性の高いものである上、鉄等の金属製の医療器具に対して特に良好な防錆効果を付与できる。 The drying pretreatment agent according to the invention of claim 8 is a highly safe benzoic acid or salt thereof, arginine, polylysine used as an organic rust inhibitor and approved for food additives. A particularly good antirust effect can be imparted to a metallic medical instrument.
請求項9の発明に係る乾燥前処理剤は、上記の可溶化剤が食品添加物に認可された特定成分からなるため、安全性を確保して且つ原液における高濃度の界面活性剤に対して良好な可溶化作用が得られる。 The pretreatment agent for drying according to the invention of claim 9 is based on the above-mentioned solubilizer consisting of specific components approved for food additives, so that safety is ensured and against high concentration surfactant in the stock solution. Good solubilizing action can be obtained.
請求項10の発明に係る医療器具の再生処理方法によれば、使用済み医療器具に洗浄及び濯ぎを施したのち、乾燥処理前に上記の乾燥前処理剤を極めて低濃度の水希釈液として付与するから、乾燥時間を大幅に短縮して、且つ器具表面のウォータースポットやシミ等の生成を防止できると共に、該医療器具に高い防錆効果及び潤滑効果を付与できる上、その乾燥前処理を低コストで経済的に行える。
According to the medical device regeneration processing method of the invention of
請求項11の発明によれば、上記の医療器具の再生処理方法において、特に水希釈液の界面活性剤濃度を特定範囲に設定するから、高い乾燥促進効果を確保しながら、処理後の医療器具表面の乾燥残渣の低減とべたつき防止を図ることができる。 According to the eleventh aspect of the present invention, in the medical device regeneration processing method described above, since the surfactant concentration of the water dilution is set within a specific range, the medical device after processing is secured while ensuring a high drying acceleration effect. Reduction of dry residue on the surface and prevention of stickiness can be achieved.
本発明に係る医療器具の乾燥前処理剤は、既述のように、有機防錆剤と、界面活性剤と、該界面活性剤に対する可溶化剤とを有効成分として含有するものであり、反復利用する医療器具の使用後に洗浄・濯ぎを行って乾燥して再生させる際、その乾燥前の医療器具に対して極めて低濃度の水希釈液として付与するものであり、前記洗浄後の濯ぎ工程での最終濯ぎ液、もしくは濯ぎ後の別工程としての浸漬方式における処理液として用いる。 The medical device drying pretreatment agent according to the present invention contains, as described above, an organic rust preventive agent, a surfactant, and a solubilizer for the surfactant as active ingredients. When cleaning and rinsing after use of the medical device to be used and drying and regenerating it, it is given to the medical device before drying as an extremely low-concentration water diluting solution. In the rinsing step after the cleaning, It is used as a final rinsing liquid or a treatment liquid in a dipping method as a separate process after rinsing.
しかして、この乾燥前処理剤によれば、乾燥時間を大幅に短縮できて、且つ器具表面のウォータースポットやシミ等の生成を防止できる上、従来のような乳化型の潤滑防錆剤を含有させることなく高い防錆効果及び潤滑効果を付与できる。また、この乾燥前処理剤では、上記のような極めて低濃度の水希釈液として用いることで処理コストを著しく低減できると共に、各有効成分として食品添加物に認可されたもの(食品添加物公定書に記載のもの)を選択することで高い安全性を確保することが可能であり、加えて原液状態で0℃程度の低温域から40℃程度の高温域まで安定した性状を保持するため、例えば冷蔵庫等による低温下での長期保存や夏期における高温下での流通過程で変質する懸念がない。 Therefore, according to this pre-drying treatment agent, the drying time can be greatly shortened and the generation of water spots and spots on the surface of the instrument can be prevented, and a conventional emulsification type lubricating rust preventive agent is contained. A high rust prevention effect and a lubrication effect can be imparted without making them. In addition, with this pre-drying treatment agent, the treatment cost can be remarkably reduced by using it as an extremely low-concentration water dilution solution as described above. In order to maintain a stable property from a low temperature range of about 0 ° C. to a high temperature range of about 40 ° C. in a stock solution state, for example, There is no concern of deterioration during long-term storage at low temperatures, such as in refrigerators, and distribution processes at high temperatures in summer.
本発明に用いる上記の有機防錆剤は、鉄やステンレス鋼等の金属製の医療器具に対する防錆効果を発揮するものであればよいが、医療器具用としての安全性面より、有機酸又はその塩、アミノ酸、ポリペプチドが好適なものとして挙げられる。そして、これらは1種を単独で使用してもよいし、2種以上を組み合わせて用いてもよい。ただし、材料コストの面からは、有機酸又はその塩が好ましい。 The organic rust preventive agent used in the present invention only needs to exhibit a rust preventive effect on metal medical instruments such as iron and stainless steel, but from the viewpoint of safety for medical instruments, an organic acid or Suitable salts thereof include amino acids and polypeptides. And these may be used individually by 1 type and may be used in combination of 2 or more type. However, from the viewpoint of material cost, an organic acid or a salt thereof is preferable.
上記の有機防錆剤に用いる有機酸又はその塩としては、食品添加物に認可されたもの、例えばクエン酸、コハク酸、リンゴ酸、フマル酸、酢酸、安息香酸、これらのアルカリ金属塩等が挙げられるが、特に安息香酸ナトリウムが防錆効果に優れて且つ安価に入手できる点から推奨される。 Organic acids or salts thereof used for the above organic rust preventives include those approved for food additives such as citric acid, succinic acid, malic acid, fumaric acid, acetic acid, benzoic acid, and alkali metal salts thereof. In particular, sodium benzoate is recommended because it has an excellent rust prevention effect and is available at low cost.
同じく有機防錆剤に用いるアミノ酸としては、アラニン、バリン、ロイシン、イソロイシン、プロリン、メチオニン、フェニルアラニン、トリプトファン、グリシン、セリン,トリオニン、アスバラギン酸、アスパラギン、グルタミン酸,グルタミン、システィン、ヒスチジン、リジン、アルギニン、チロシン、これらの塩等が挙げられるが、特にアルギニンが防錆効果に優れる点から推奨される。 Similarly, amino acids used for organic rust preventives include alanine, valine, leucine, isoleucine, proline, methionine, phenylalanine, tryptophan, glycine, serine, trionine, aspartic acid, asparagine, glutamic acid, glutamine, cysteine, histidine, lysine, arginine, Examples include tyrosine and salts thereof, and arginine is particularly recommended because of its excellent antirust effect.
同じく有機防錆剤に用いるポリペプチドとしては、食品添加物に認可されているポリリジンが防錆効果に優れる点から好適である。 Similarly, as a polypeptide used for the organic rust preventive agent, polylysine approved as a food additive is preferable because of its excellent rust preventive effect.
本発明に用いる界面活性剤は、可動部を有する医療器具に対する潤滑作用と乾燥促進作用の両作用を付与するための成分であり、前記可溶化剤及び水に溶解できるものであれば、非イオン界面活性剤、アニオン界面活性剤、カチオン界面活性剤、両性界面活性剤のいずれでもよいが、医療器具に適用する上で毒性の問題がないものが望ましく、特に食品添加物に認可されるものが好ましい。 The surfactant used in the present invention is a component for imparting both a lubricating action and a drying accelerating action to a medical device having a movable part, and any nonionic ion can be used as long as it can be dissolved in the solubilizer and water. Any of surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants may be used, but those that do not have toxicity problems when applied to medical devices are desirable, especially those that are approved for food additives. preferable.
その具体例としては、グリセリン脂肪酸エステル、グリセリン酢酸脂肪酸エステル、グリセリン乳酸脂肪酸エステル、グリセリンコハク酸脂肪酸エステル、グリセリンジアセチル酒石酸脂肪酸エステル、ポリグリセリン脂肪酸エステル、ソルビタン脂肪酸エステル、ショ糖脂肪酸エステル、プロピレングリコール脂肪酸エステル、ポリグリコール縮合リシノレイン酸エステル、ポリオキシエチレンソルビタン脂肪酸エステル、レシチン等が挙げられる。そして、これらは1種を単独で使用してもよいし、2種以上を組み合わせて用いてもよい。また、これら界面活性剤の中でも、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ソルビタン脂肪酸エステル、ショ糖脂肪酸エステル、ポリオキシエチレンソルビタン脂肪酸エステル、レシチンが潤滑作用及び乾燥促進作用に優れる点から推奨され、特にグリセリン脂肪酸エステルが好適なものとして挙げられる。更に、このグリセリン脂肪酸エステルにおいても、より優れた乾燥促進作用が得られる点で炭素数が10のカプリン酸モノグリセリドが最適であり、2種以上の界面活性剤を併用する場合でもカプリン酸モノグリセリドを必須成分として含むことが望ましい。 Specific examples thereof include glycerin fatty acid ester, glycerin acetic acid fatty acid ester, glycerin lactic acid fatty acid ester, glycerin succinic acid fatty acid ester, glycerin diacetyl tartaric acid fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, propylene glycol fatty acid ester. , Polyglycol condensed ricinoleic acid ester, polyoxyethylene sorbitan fatty acid ester, lecithin and the like. And these may be used individually by 1 type and may be used in combination of 2 or more type. Among these surfactants, glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, polyoxyethylene sorbitan fatty acid ester, and lecithin are recommended because they are excellent in lubricating action and drying promoting action. Glycerin fatty acid esters are preferred. Furthermore, in this glycerin fatty acid ester, a capric acid monoglyceride having 10 carbon atoms is optimal in that a better drying accelerating action can be obtained, and capric acid monoglyceride is essential even when two or more surfactants are used in combination. It is desirable to include it as a component.
なお、各界面活性剤の好適な市販品としては、次のようなものが挙げられる。太陽化学社製のサンソフトシリーズ、及び理研ビタミン社製のポエムシリーズにおけるカプリン酸グリセリド。前記サンソフトシリーズ、前記ポエムシリーズ、及び花王社製のホモテックスシリーズにおけるカプリル酸グリセリド。第一工業製薬社製のDKエステルシリーズにおけるショ糖脂肪酸エステル。前記サンソフトシリーズ、前記ポエムシリーズ、及び第一工業製薬社製のソルゲンシリーズにおけるソルビタン脂肪酸エステル。阪本薬品工業社製のSYグリスターシリーズ、前記サンソフトシリーズ、前記ポエムシリーズにおけるカプリル酸デカグリセリン。日油社製のウィルサーフシリーズ、及び第一工業製薬社製のソルボンシリーズにおけるポリオキシエチレンソルビタン脂肪酸エステル。理研ビタミン社製のレシオンシリーズ、及び太陽化学社製のサンレシチンシリーズにおけるレシチン。 In addition, the following are mentioned as a suitable commercial item of each surfactant. Capric acid glycerides in the Sunsoft series made by Taiyo Kagaku and the Poem series made by Riken Vitamin. Caprylic acid glyceride in the Sunsoft series, the Poem series, and the Kamo Corporation Hotex series. Sucrose fatty acid ester in the DK ester series manufactured by Daiichi Kogyo Seiyaku. Sorbitan fatty acid esters in the Sunsoft series, the Poem series, and the Sorgen series manufactured by Daiichi Kogyo Seiyaku. Decaglyceryl caprylate in SY Glyster series, Sakasoft series and Poem series manufactured by Sakamoto Pharmaceutical Co., Ltd. Polyoxyethylene sorbitan fatty acid ester in the Will Surf series made by NOF Corporation and the Sorbone series made by Daiichi Kogyo Seiyaku. Lecithin in the Lesion series manufactured by Riken Vitamin Co., Ltd. and the San lecithin series manufactured by Taiyo Kagaku Co., Ltd.
本発明の乾燥前処理剤をウオッシャーディスインフェクターや蛇管洗浄機のような噴射洗浄機に適用する場合は、含有する界面活性剤が低泡性であることが望ましい。この低泡性の界面活性剤としては、グリセリン脂肪酸エステルで炭素数が6〜18であるもの、より好ましくは同炭素数が8〜12のものが推奨され、特に炭素数が8のカプリル酸モノグリセリドが最適である。他の界面活性剤は、HLB(親水親油バランス)の如何に関わらず泡立ちが多いため、浸漬方式に適用する乾燥前処理剤に用いることが推奨される。なお、乾燥促進作用と低泡性の両面で最も好結果を得るには、カプリル酸モノグリセリドとカプリン酸モノグリセリドとの組合せがよい。特に、カプリル酸モノグリセリドとカプリン酸モノグリセリドとを前者:後者の重量比で1:0.5〜1.5、最適には1:0.7〜1.2の併用割合とすれば、噴射洗浄機に適用して高い乾燥促進作用を発揮できることに加え、良好な潤滑効果及び原液安定性が得られる。 When the pre-drying treatment agent of the present invention is applied to a jet washer such as a washer disinfector or a serpentine washer, it is desirable that the surfactant contained has low foaming properties. As this low-foaming surfactant, a glycerin fatty acid ester having 6 to 18 carbon atoms, more preferably one having 8 to 12 carbon atoms is recommended, and particularly a caprylic acid monoglyceride having 8 carbon atoms. Is the best. Since other surfactants have much foam regardless of HLB (Hydrophilic Lipophilic Balance), it is recommended to use them as a pretreatment for drying applied to the dipping method. In order to obtain the best results both in terms of drying acceleration and low foaming properties, a combination of caprylic acid monoglyceride and capric acid monoglyceride is preferable. In particular, if a caprylic acid monoglyceride and capric acid monoglyceride are used in a combined ratio of 1: 0.5 to 1.5, most preferably 1: 0.7 to 1.2, in the former: latter weight ratio, the jet washer In addition to being able to exhibit a high drying accelerating action when applied to the above, a good lubricating effect and stock solution stability can be obtained.
一方、浸漬方式に適用する乾燥前処理剤は、浸漬処理槽に収容した状態で長時間(通常は1日の操業中の間)継続的に使用するのが一般的であることに加え、処理効率を高めるために50℃程度に加温する場合もあるため、極低濃度の水希釈液として使用するものではその希釈状態で性状的に安定していることが必要である。しかるに、前記のような低泡性の界面活性剤は、概して希釈安定性に乏しく、極低濃度の水希釈液では時間経過に伴って分離等の性状変化をきたし易いため、その単独使用や他の界面活性剤との併用で配合比率が多い形では浸漬方式用には不向きである。従って、浸漬方式用の乾燥前処理剤において、界面活性剤として例えば前記の乾燥促進作用に優れるカプリン酸モノグリセリドを用いる場合、水希釈液の安定性を確保する上で、このカプリン酸モノグリセリドを単独で使用するか、他との併用の場合にはHLBの高い界面活性剤との組合せにすることが好ましい。なお、この組合せに好適なHLBの高い界面活性剤としては、ポリグリセリン脂肪酸エステル、ソルビタン脂肪酸エステル、ショ糖脂肪酸エステル、ポリオキシエチレンソルビタン脂肪酸エステル、レシチン等が挙げられる。 On the other hand, the pre-drying treatment agent applied to the dipping method is generally used continuously for a long time (usually during the operation for one day) in a state of being accommodated in the dipping treatment tank. In order to increase the temperature, it may be heated to about 50 ° C., so that it should be qualitatively stable in the diluted state if it is used as an extremely low concentration water dilution. However, the low-foaming surfactants as described above generally have poor dilution stability, and extremely low-concentration water dilutions are liable to change in properties such as separation over time. In the form with a large blending ratio in combination with this surfactant, it is not suitable for the dipping method. Therefore, in the pre-drying treatment agent for the dipping method, for example, when using the capric acid monoglyceride having excellent drying promoting action as a surfactant, the capric acid monoglyceride alone is used to ensure the stability of the water dilution. When used in combination with other, it is preferable to use a combination with a surfactant having a high HLB. Examples of the surfactant having a high HLB suitable for this combination include polyglycerin fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, polyoxyethylene sorbitan fatty acid ester, and lecithin.
本発明に用いる可溶化剤は、前記の界面活性剤を可溶化させる機能を有するものであるが、医療器具に適用する上で食品添加物に認可されたものがよく、例えばエタノール、グリセリン、プロピレングリコール等が好適なものとして挙げられ、特に乾燥によって揮発するエタノールが医療器具にべたつきを生じない点から推奨される。なお、これら例示した可溶化剤はアルコール系であるが、本発明の乾燥前処理剤が既述のように極めて低濃度の水希釈液(一般的に水分量が99質量%以上)として使用することから、アルコールとしての乾燥促進作用をもたらすものではない。 The solubilizer used in the present invention has a function of solubilizing the above-mentioned surfactant, but those which are approved as food additives for application to medical devices are preferable, for example, ethanol, glycerin, propylene Glycols and the like are preferred, and ethanol that volatilizes by drying is particularly recommended because it does not cause stickiness to medical devices. These exemplified solubilizers are alcoholic, but the drying pretreatment agent of the present invention is used as an extremely low-concentration water diluting solution (generally having a water content of 99% by mass or more) as described above. Therefore, it does not bring about the drying acceleration action as alcohol.
本発明の乾燥前処理剤における各成分の好適な含有量は、有機防錆剤が0.1〜5質量%、界面活性剤が4〜60質量%、可溶化剤が1〜50質量%の各範囲であるが、これらは乾燥前処理剤の原液として含有量である。しかして、有機防錆剤及び界面活性剤の含有量は、少な過ぎては後述する使用時の水希釈液とした場合の濃度が低過ぎて充分な作用効果を発揮できず、逆に多過ぎては原液としての安定性が悪くなる。なお、可溶化剤の含有量は、流通及び保管の際の温度に対応して、低温では少なく高温では多くなるように上記範囲内で設定すればよい。 The suitable content of each component in the drying pretreatment agent of the present invention is 0.1 to 5% by mass of the organic rust inhibitor, 4 to 60% by mass of the surfactant, and 1 to 50% by mass of the solubilizer. Although it is each range, these are content as a stock solution of a drying pretreatment agent. Therefore, if the content of the organic rust inhibitor and the surfactant is too small, the concentration in the case of a water dilution at the time of use, which will be described later, is too low to exhibit a sufficient effect, and conversely too much. As a result, the stability as a stock solution is deteriorated. In addition, what is necessary is just to set the content of a solubilizer within the said range so that it may correspond at the temperature at the time of distribution | circulation and storage, and it may increase at high temperature at low temperature.
本発明の乾燥前処理剤を使用する際は、水希釈によって水分量が99質量%以上となる水希釈液とするのがよい。この水希釈率が低すぎては、作用効果の増大が僅かであるのに対して、乾燥前処理における有効成分消費量が多くなるために不経済である。しかして、上記使用実施例の特に好適な水希釈液としては、界面活性剤濃度が0.02〜0.1質量%の範囲になるものがよく、この界面活性剤濃度が低過ぎては乾燥促進効果及び潤滑効果が不充分になり、逆に高過ぎては両効果の増大が殆ど期待できないために不経済であることに加え、乾燥残渣が多くなってべたつきを生じ易くなる。 When using the drying pretreatment agent of the present invention, it is preferable to use a water diluting solution in which the water content becomes 99% by mass or more by dilution with water. If the water dilution rate is too low, the increase in the effect is slight, but the amount of active ingredient consumed in the pre-drying treatment increases, which is uneconomical. Therefore, as a particularly preferable water dilution liquid in the above-mentioned use examples, a surfactant having a surfactant concentration in the range of 0.02 to 0.1% by mass is preferable, and if this surfactant concentration is too low, it is dried. The acceleration effect and the lubrication effect become insufficient. On the other hand, if it is too high, the increase in both effects can hardly be expected, which is uneconomical.
また、本発明の乾燥前処理剤は、界面活性剤濃度0.02質量%となる水希釈液のSUS410表面に対する滴下3分後の接触角が21°未満になるように設定するのがよい。これは、後述する実施例1の乾燥前処理剤における界面活性剤濃度と接触角と乾燥促進効果との相関を示す図1及び図2から明らかなように、界面活性剤濃度が0質量%から増えるに従って乾燥時間が短くなり、乾燥時間と接触角との間に正の相関があるが、界面活性剤濃度0.02質量%となる水希釈液の上記接触角が21°未満の場合に乾燥時間を40質量%以上短縮でき、充分な乾燥促進効果が得られることによる。そして、該接触角は、界面活性剤濃度0.04質量%でほぼ最低レベルになり、界面活性剤濃度が更に高くなっても殆ど変化しない。つまり、乾燥促進効果は界面活性剤濃度0.04質量%でほぼ飽和に達し、該濃度がより高くなっても更なる効果の増大は期待できない。なお、接触角の測定対象をSUS410としているのは、医療機関において鋼製小物として多用される医療器具が一般的にSUS410製であることによる。 In addition, the pre-drying treatment agent of the present invention is preferably set so that the contact angle after 3 minutes of dropping of the water dilution with a surfactant concentration of 0.02% by mass on the SUS410 surface is less than 21 °. As is apparent from FIGS. 1 and 2 showing the correlation between the surfactant concentration, the contact angle, and the drying acceleration effect in the pre-drying treatment agent of Example 1 described later, the surfactant concentration is from 0% by mass. As the time increases, the drying time becomes shorter, and there is a positive correlation between the drying time and the contact angle. However, the drying time is less than 21 ° when the contact angle of the water diluted solution with the surfactant concentration of 0.02% by mass is less than 21 °. This is because the time can be shortened by 40% by mass or more, and a sufficient drying acceleration effect can be obtained. The contact angle becomes almost the lowest level at a surfactant concentration of 0.04% by mass, and hardly changes even when the surfactant concentration is further increased. That is, the drying acceleration effect reaches almost saturation at a surfactant concentration of 0.04% by mass, and further increase in the effect cannot be expected even when the concentration becomes higher. The reason for measuring the contact angle as SUS410 is that medical instruments that are frequently used as small steel articles in medical institutions are generally made of SUS410.
噴射洗浄機による乾燥前処理を行うには、濯ぎ後の乾燥前の工程(最終濯ぎ工程)として、乾燥前処理剤の前記水希釈液の一定量を濯ぎ水タンクに収容し、濯ぎ後の医療器具に対して自動で噴射させる。このとき、水希釈液の温度は、低温での泡立ちを考慮して30℃以上とすることが望ましい。一方、浸漬方式による乾燥前処理は、乾燥前処理剤の前記水希釈液を収容した浸漬処理槽内に、洗浄及び濯ぎを経た医療器具を数10秒〜数分程度浸漬して引き上げる。そして、これら前処理後の医療器具は、適当な乾燥機内に収容し、所要温度で乾燥させればよい。 In order to perform the pre-drying treatment by the spray washing machine, as a pre-drying step after the rinsing (final rinsing step), a certain amount of the water diluted solution of the pre-drying treatment agent is stored in the rinsing water tank, and the medical treatment after the rinsing Automatically spray on the instrument. At this time, it is desirable that the temperature of the water dilution is 30 ° C. or higher in consideration of foaming at a low temperature. On the other hand, in the pre-drying treatment by the dipping method, the medical device that has undergone washing and rinsing is dipped in the immersion treatment tank containing the water dilution liquid of the pre-drying treatment agent for about several tens of seconds to several minutes and then pulled up. Then, these pretreated medical instruments may be accommodated in a suitable dryer and dried at a required temperature.
以下に、本発明を実施例及び比較例によって具体的に説明するが、本発明はその要旨を逸脱しない限りは以下の実施例に制約されるものではない。なお、以下において%とあるのは、質量%を意味する。また、実施例で使用した界面活性剤の内訳(商品名)は次のとおりである。 EXAMPLES Hereinafter, the present invention will be specifically described with reference to examples and comparative examples, but the present invention is not limited to the following examples without departing from the gist thereof. In the following description,% means mass%. Moreover, the breakdown (brand name) of the surfactant used in the Examples is as follows.
カプリン酸モノグリセリド・・・太陽化学社製のサンソフトNo.760(副成分としてジ及 びトリグリセリドを微量含有)
カプリル酸モノグリセリド・・・花王社製のホモテックスPT(副成分としてジ及びト リグリセリドを微量含有)
ショ糖ラウリン酸エステル・・・第一工業製薬社製のDKエステルSL18A
ソルビタン脂肪酸エステル・・・第一工業製薬社製のソルゲン110
カプリル酸ヘキサグリセリン・・・太陽化学社製のサンソフトQ-81F
カプリル酸デカグリセリン・・・阪本薬品工業社製のSYグリスターM750
ポリオキシエチレンソルビタン脂肪酸エステル・・・日油社製のウィルサーフTF-20 レシチン・・・太陽化学社製のサンレシチンA
Capric acid monoglyceride: Sunsoft No.760 manufactured by Taiyo Kagaku Co. (contains trace amounts of di- and triglycerides as accessory ingredients)
Caprylic acid monoglyceride: Homotex PT manufactured by Kao Corporation (contains trace amounts of di- and triglycerides as accessory components)
Sucrose laurate ester DK ester SL18A made by Daiichi Kogyo Seiyaku
Sorbitan fatty acid ester: Sorgen 110 from Daiichi Kogyo Seiyaku
Hexaglycerin caprylate ... Sunsoft Q-81F manufactured by Taiyo Kagaku
Caprylic acid decaglycerin SY Glycer M750 from Sakamoto Pharmaceutical Co., Ltd.
Polyoxyethylene sorbitan fatty acid ester ... Wilsurf TF-20 lecithin manufactured by NOF Corporation ... Sun lecithin A manufactured by Taiyo Chemical Co., Ltd.
実施例1〜22
後記表1及び表2記載の配合組成を有する乾燥前処理剤(原液)を調製すると共に、この乾燥前処理剤に水を加えて200容積倍の水希釈液を調製した。
Examples 1-22
While preparing the pre-drying processing agent (stock solution) which has a compounding composition of postscript Table 1 and Table 2, water was added to this pre-drying processing agent, and the 200 volume volume water dilution liquid was prepared.
比較例1
市販の流動パラフィン乳化型潤滑防錆剤A(ステリスジャパン社製のヒンジフリー・・・原液)を用い、メーカー推奨濃度に準じて水を加えて200容積倍の水希釈液を調製した。
Comparative Example 1
Using a commercially available liquid paraffin emulsified lubricating rust preventive agent A (hinge free ... stock solution manufactured by Steris Japan), water was added according to the manufacturer's recommended concentration to prepare a 200-fold volume aqueous dilution.
比較例2
市販の流動パラフィン乳化型潤滑防錆剤B(Dr.Weigert社製のneodisher IP・・・原液)を用い、メーカー推奨濃度に準じて水を加えて500容積倍の水希釈液を調製した。
Comparative Example 2
Using a commercially available liquid paraffin emulsified lubricating rust preventive agent B (neodisher IP... Stock solution manufactured by Dr. Weigert), water was added according to the manufacturer's recommended concentration to prepare a 500-fold volume aqueous dilution.
比較例3
市販の流動パラフィン乳化型潤滑防錆剤C(シャープ社製の MM100・・・原液)を用い、メーカー推奨濃度に準じて水を加えて100容積倍の水希釈液を調製した。
Comparative Example 3
Using a commercially available liquid paraffin emulsification type lubricating rust inhibitor C (Sharp MM100: Stock solution), water was added according to the manufacturer's recommended concentration to prepare a 100-fold volume water dilution.
以上の実施例及び比較例で調製した各水希釈液について、希釈安定性、噴射洗浄機適性、乾燥残渣、防錆性、潤滑性、使用液接触角、乾燥促進効果の各項目を調べた。なお、参考として単なる水(水道水)についても同様の各項目を調べた。その結果を、乾燥前処理剤原液の安定性、界面活性剤0.02%時の接触角の各測定結果と共に後記表1及び表2に示す。なお、各項目の試験方法及び評価は次のとおりである。 About each water dilution liquid prepared by the above Example and comparative example, each item of dilution stability, jet-washing machine suitability, drying residue, rust prevention property, lubricity, use liquid contact angle, and drying acceleration effect was investigated. For reference, the same items were examined for simple water (tap water). The results are shown in Tables 1 and 2 below, together with the measurement results of the stability of the pre-drying treatment agent stock solution and the contact angle when the surfactant was 0.02%. The test method and evaluation for each item are as follows.
〔希釈安定性〕
各水希釈液の1Lを60℃で最長8時間保持し、その時間経過による性状変化を観察し、次の3段階で安定性を評価した。
○・・・8時間経過しても分離等の性状変化が認められなかった。
△・・・1時間超から8時間未満で分離や不均一化を生じた。
×・・・1時間未満で分離や不均一化を生じた。
[Dilution stability]
1 L of each water dilution was held at 60 ° C. for a maximum of 8 hours, the property change over time was observed, and the stability was evaluated in the following three stages.
○ ... No property change such as separation was observed even after 8 hours.
Δ: Separation or non-uniformity occurred in over 1 hour to less than 8 hours.
X: Separation or non-uniformity occurred in less than 1 hour.
〔噴射洗浄機適性〕
噴射洗浄機として Miele社製のウオッシャーディスインフェクターG7836を用い、各水希釈液を最終濯ぎ工程に投入し、泡立ちによる液漏れやエラーの有無を調べ、その結果を次の3段階で評価した。
○・・・正常な作動で最終濯ぎ工程を終えた。
△・・・液漏れはないが、明らかな噴射圧低下が認められた。
×・・・洗浄機から液漏れが発生した。
[Applicability to spray cleaning machine]
Using a washer-disinfector G7836 manufactured by Miele as a spray cleaning machine, each water dilution was put into the final rinsing process, and the presence or absence of liquid leakage or error due to foaming was examined, and the results were evaluated in the following three stages.
○ The final rinsing process was completed with normal operation.
Δ: There was no liquid leakage, but a clear drop in the injection pressure was observed.
X: Liquid leakage occurred from the washer.
〔乾燥残渣〕
各希釈液にステンレス鋼板(SUS410、5cm×5cm)を30秒間浸漬したのち、引き揚げて乾燥機内に吊り下げて100℃にて乾燥させ、乾燥後のステンレス鋼板の表面状態を目視観察し、次の3段階で評価した。
○・・・全くシミが認められなかった。
△・・・1〜4カ所のシミが認められた。
×・・・5カ所以上にシミが認められた。
[Dry residue]
After dipping a stainless steel plate (SUS410, 5 cm × 5 cm) in each diluted solution for 30 seconds, it is lifted and suspended in a dryer and dried at 100 ° C., and the surface condition of the dried stainless steel plate is visually observed. Evaluation was made in three stages.
○: No spots were observed.
Δ: 1 to 4 spots were observed.
×: Spots were observed at 5 or more locations.
〔防錆性〕
ビーカーに収容した各希釈液200ml中に、 表面研磨(サンドペーパーAA240)及び脱脂処理(アセトン)を施した鉄板(圧延鉄鋼板、JIS G 3141)を浸漬し、電熱器で液を95℃まで昇温して10分間維持したのち、取り出した鉄板を空気中で立てかけておいて表面状態を目視観察し、次の3段階で評価した。
○・・・錆及び変色が全く認められなかった。
△・・・錆及び変色が1〜4カ所に認められた。
×・・・錆及び変色が5カ所以上に認められた。
[Rust prevention]
In 200 ml of each diluted solution contained in a beaker, a steel plate (rolled steel plate, JIS G 3141) that has been subjected to surface polishing (sandpaper AA240) and degreasing (acetone) is immersed, and the temperature is raised to 95 ° C. with an electric heater. After heating and maintaining for 10 minutes, the taken-out iron plate was stood up in the air, the surface state was visually observed, and it evaluated in the following three steps.
○: Rust and discoloration were not recognized at all.
Δ: Rust and discoloration were observed in 1 to 4 places.
X: Rust and discoloration were observed in 5 or more places.
〔潤滑性〕
各希釈液にステンレス鋼製試験片(直径3mmのボール4個と、直径1mm,長さ3mmの円柱状ピン1本)を30秒間浸漬したのち、引き揚げて乾燥機内に吊り下げて100℃にて乾燥させ、放冷後の試験片表面の動摩擦係数を振子式II型の動摩擦係数測定装置によって測定し、その測定値が0.12以下であるものを○(良好)として評価した。
(Lubricity)
A stainless steel test piece (4 balls with a diameter of 3 mm and 1 cylindrical pin with a diameter of 1 mm and a length of 3 mm) was immersed in each diluted solution for 30 seconds, then lifted and suspended in a dryer at 100 ° C. The dynamic friction coefficient of the test piece surface after drying and allowing to cool was measured with a pendulum type II type dynamic friction coefficient measuring device, and the measurement value was 0.12 or less and evaluated as ◯ (good).
〔使用液接触角〕
接触角計(協和界面科学社製M-360)を用い、各水希釈液のステンレス鋼(SUS410)表面に対する滴下から3分後の接触角を測定した。
[Use liquid contact angle]
Using a contact angle meter (M-360, manufactured by Kyowa Interface Science Co., Ltd.), the contact angle after 3 minutes from the dropping of each water dilution onto the stainless steel (SUS410) surface was measured.
〔乾燥促進効果〕
ワイヤーバスケットに収容した止血鉗子(長さ14.5cm)50本を各水希釈液に1分間浸漬したのち、引き揚げて乾燥機内に吊り下げて100℃で乾燥させ、この乾燥過程で経時的重量変化を測定し、完全乾燥に要する時間を調べた。評価は、水濯ぎだけの場合(参考例)の完全乾燥時間に対する短縮率により、次の4段階で評価した。
◎・・・短縮率55%以上
○・・・短縮率40%以上〜55%未満
△・・・短縮率30%以上〜40%未満
×・・・短縮率30%未満
[Drying acceleration effect]
After 50 hemostatic forceps (length: 14.5cm) contained in a wire basket are immersed in each water dilution for 1 minute, they are lifted and suspended in a dryer and dried at 100 ° C. The time required for complete drying was measured. The evaluation was made in the following four stages based on the shortening rate with respect to the complete drying time in the case of only water rinsing (reference example).
◎ ・ ・ ・ Reduction rate 55% or more ○ ・ ・ ・
〔乾燥前処理剤原液の安定性〕
前記実施例及び比較例で調製した乾燥前処理剤原液について、各100mlを冷蔵庫及び温蔵庫によって2℃の低温下と40℃の高温下で保存し、液の状態を目視観察し、次の3段階で評価した。
○・・・低温下及び高温下共に1カ月以上経過しても変化なく清澄であった。
△・・・低温下と高温下の一方又は両方で1週間超から1カ月未満に分離、変色、沈 殿の何れかが認められた。
×・・・低温下と高温下の一方又は両方で1週間未満に分離、変色、沈殿の何れかが 認められた。
[Stability of stock solution of pretreatment agent for drying]
About the dry pretreatment agent stock solutions prepared in the above Examples and Comparative Examples, each 100 ml was stored at a low temperature of 2 ° C. and a high temperature of 40 ° C. with a refrigerator and a warm storage, and the state of the liquid was visually observed, Evaluation was made in three stages.
A: Clear even after one month or more at both low and high temperatures.
Δ: Separation, discoloration, or precipitation was observed from one week to less than one month at one or both of low and high temperatures.
X: Separation, discoloration, or precipitation was observed in one or both of low temperature and high temperature in less than one week.
〔界面活性剤0.02%時の接触角〕
各水希釈液を更に界面活性剤濃度が0.02%になるまで水で希釈し、この界面活性剤濃度0.02%の水希釈液について、接触角計(協和界面科学社製M-360)を用いてステンレス鋼(SUS410)表面に対する滴下から3分後の接触角を測定した。
[Contact angle when surfactant is 0.02%]
Each water dilution is further diluted with water until the surfactant concentration becomes 0.02%, and a contact angle meter (M-360 manufactured by Kyowa Interface Science Co., Ltd.) is used for the water dilution having a surfactant concentration of 0.02%. ) Was used to measure the contact angle after 3 minutes from dropping on the stainless steel (SUS410) surface.
表1及び表2で示すように、本発明の乾燥前処理剤によれば、200倍もの水希釈による極低濃度の水希釈液として医療器具表面に付与することで、乾燥時間をほぼ50%以上短縮できる上、従来の流動パラフィン乳化型潤滑防錆剤と同等以上の優れた防錆性が得られている。特に界面活性剤としてカプリン酸モノグリセリドとカプリル酸モノグリセリドとを同量併用した場合(実施例1〜3,実施例11,12)、ならびにカプリン酸モノグリセリドとショ糖ラウリン酸エステルとを同量併用した場合(実施例4)は、乾燥時間が55%以上短縮されている。ただし、カプリル酸モノグリセリドの単独使用(実施例13)では、乾燥促進効果にやや劣る。しかして、良好な乾燥促進効果を発揮する乾燥前処理剤は、界面活性剤濃度0.02%の水希釈液でのSUS410に対する接触角が21°以下となっている。更に、本発明の乾燥前処理剤では、各別な潤滑剤成分を配合していないにも関わらず、上記の極低濃度の水希釈液として用いることにより、医療器具に良好な潤滑性を付与できることが判る。なお、界面活性剤の総量が少ない乾燥前処理剤(実施例10,13〜16)では潤滑効果がやや低くなっている。 As shown in Tables 1 and 2, according to the drying pretreatment agent of the present invention, the drying time is approximately 50% by being applied to the surface of the medical device as an extremely low-concentration water dilution solution by 200 times water dilution. In addition to being able to shorten the above, excellent rust prevention properties equivalent to or better than those of conventional liquid paraffin emulsified lubricants are obtained. In particular, when the same amount of capric acid monoglyceride and caprylic acid monoglyceride are used in combination as surfactants (Examples 1 to 3, Examples 11 and 12), and the same amount of capric acid monoglyceride and sucrose laurate are used in combination. In Example 4, the drying time is shortened by 55% or more. However, use of caprylic acid monoglyceride alone (Example 13) is somewhat inferior in drying acceleration effect. Thus, the drying pretreatment agent that exhibits a good drying accelerating effect has a contact angle of 21 ° or less with respect to SUS410 in an aqueous diluent having a surfactant concentration of 0.02%. Furthermore, in the pre-drying treatment agent of the present invention, good lubricity is imparted to a medical device by using it as the above-mentioned extremely low-concentration water diluting solution, even though each lubricant component is not blended. I understand that I can do it. In addition, the lubrication effect is somewhat low in the drying pretreatment agent (Examples 10 and 13 to 16) in which the total amount of the surfactant is small.
また、これら表1及び表2より、乾燥前処理剤原液の安定性については、界面活性剤としてカプリン酸モノグリセリドを単独で含む(実施例10)か、他との併用でもカプリン酸モノグリセリドの割合が40質量%超と高いもの(実施例1〜9、14〜17)が良好であることが判る。一方、希釈安定性は、界面活性剤としてカプリン酸モノグリセリドを含まない(実施例4〜10)か、含む場合でもその割合が低いもの(実施例14,15)が良好であることが判る。逆に、噴射洗浄機に対する適用性は、希釈安定性の悪い乾燥前処理剤の方がよいという結果になっている。 Moreover, from these Tables 1 and 2, the stability of the pre-drying treatment agent stock solution contains capric acid monoglyceride alone as a surfactant (Example 10), or the proportion of capric acid monoglyceride is also used in combination with others. It turns out that what is as high as more than 40 mass% (Examples 1-9, 14-17) is favorable. On the other hand, the dilution stability does not contain capric acid monoglyceride as a surfactant (Examples 4 to 10), or even when it contains a low ratio (Examples 14 and 15). On the contrary, the applicability to the spray cleaning machine is that the pre-drying agent having poor dilution stability is better.
更に、実施例1〜3の乾燥前処理剤の対比から、可溶化剤の3種はいずれも原液安定性に好結果を与えると共に、乾燥促進効果、防錆効果、潤滑効果への影響にも殆ど差異はないが、ポリエチレングリコール及びグリセリンは乾燥後の医療器具表面がべとつくため、特にエタノールがよいことが判る。また、実施例1と実施例20〜22の対比から、有機防錆剤として有機酸塩の安息香酸ナトリウム、ポリペプチドのポリリジン、アミノ酸のアルギニンの3種の防錆作用はいずれも良好であるが、材料コスト面からは安息香酸ナトリウムが推奨される。 Further, from the comparison of the pretreatment agent for drying in Examples 1 to 3, all of the three solubilizers give good results to the stock solution stability, and also have an effect on the drying promotion effect, rust prevention effect, and lubrication effect. Although there is almost no difference, it can be seen that polyethylene glycol and glycerin are particularly good in ethanol because the surface of the medical device after drying is sticky. Further, from comparison between Example 1 and Examples 20 to 22, all of the three types of rust preventive action of organic acid sodium benzoate as an organic rust preventive agent, polypeptide polylysine, and amino acid arginine are good. From the viewpoint of material cost, sodium benzoate is recommended.
なお、このような乾燥前処理剤の使用により、その含有配分が乾燥後の医療器具表面に残留することになるため、含有配分の人体に対する安全性が重要な課題となる。しかるに、上述した各実施例の乾燥前処理剤は、いずれも配合成分の全てが食品添加物として認可されたものであるから、乾燥後の医療器具表面に残留しても安全性面で問題を生じる懸念はない。 In addition, since the content distribution remains on the surface of the medical device after drying by using such a pre-drying treatment agent, the safety of the content distribution to the human body is an important issue. However, since the pre-drying treatment agents of each of the above-described examples are all approved as food additives, there are problems in terms of safety even if they remain on the surface of the medical device after drying. There are no concerns that arise.
〔接触角−希釈濃度−乾燥時間の相関〕
次に、前記実施例1で調製した乾燥前処理剤の原液を後記表3記載の種々の容積倍率で水希釈し、得られた各希釈濃度〔%=(1/希釈倍率)×100〕の水希釈液について、前記同様に接触角計によるステンレス鋼(SUS410)表面に対する滴下から3分後の接触角を測定すると共に、これら水希釈液を用いて前記同様に乾燥促進効果を調べた。測定した接触角、乾燥時間(完全乾燥に要した時間)、水濯ぎだけの場合(参考例)を基準とした乾燥短縮率、前記同様の4段階の乾燥促進評価を表3に示す。また、接触角−希釈濃度と、乾燥時間−希釈濃度の両相関を図1に、接触角−乾燥短縮率の相関を図2に、それぞれ示す。
[Correlation of contact angle-dilution concentration-drying time]
Next, the stock solution of the drying pretreatment agent prepared in Example 1 was diluted with water at various volume ratios described in Table 3 below, and each of the obtained dilution concentrations [% = (1 / dilution ratio) × 100] was obtained. About the water dilution liquid, the contact angle 3 minutes after dropping with respect to the stainless steel (SUS410) surface by a contact angle meter was measured in the same manner as described above, and the drying acceleration effect was examined using these water dilution liquids as described above. Table 3 shows the measured contact angle, drying time (time required for complete drying), drying shortening rate based on the case of only water rinsing (reference example), and the same four-stage drying acceleration evaluation. Further, FIG. 1 shows the correlation between contact angle-dilution concentration and drying time-dilution concentration, and FIG. 2 shows the correlation between contact angle-drying shortening rate.
表3と図1及び図2で示すように、界面活性剤濃度が増えるに従って乾燥時間が短くなり、乾燥時間と接触角との間に正の相関があるが、界面活性剤濃度0.02%となる水希釈液の上記接触角が21°未満の場合に乾燥時間を40%以上短縮でき、充分な乾燥促進効果が得られる。そして、該接触角は、界面活性剤濃度0.04%でほぼ最低レベルになり、界面活性剤濃度が更に高くなっても殆ど変化しない。つまり、乾燥促進効果は界面活性剤濃度0.04%付近でほぼ飽和に達し、該濃度がより高くなっても更なる効果の増大は期待できない。そして、処理コスト面からは希釈倍率の下限を原液の100容積倍程度とすべきであり、充分な乾燥促進効果と経済性及び乾燥残渣低減の両方の兼ね合いで、水希釈液の界面活性剤濃度は既述のように0.02〜0.1%程度の範囲とすることが推奨される。 As shown in Table 3 and FIG. 1 and FIG. 2, the drying time decreases as the surfactant concentration increases, and there is a positive correlation between the drying time and the contact angle, but the surfactant concentration is 0.02%. When the contact angle of the diluted water solution is less than 21 °, the drying time can be shortened by 40% or more, and a sufficient drying promoting effect can be obtained. The contact angle is at the lowest level when the surfactant concentration is 0.04%, and hardly changes even when the surfactant concentration is further increased. That is, the drying acceleration effect reaches saturation almost at a surfactant concentration of about 0.04%, and further increase in the effect cannot be expected even if the concentration becomes higher. From the viewpoint of processing cost, the lower limit of the dilution ratio should be about 100 times the volume of the stock solution, and the surfactant concentration of the water dilution solution is sufficient for both the drying promotion effect, the economy, and the drying residue reduction. As described above, it is recommended that the content be in the range of about 0.02 to 0.1%.
〔有機防錆剤の濃度と防錆効果〕
次に、以下の混合液A,Bを調製し、これら混合液A,Bに水を加えて各々200容積倍の水希釈液とし、この水希釈液を用いて後記表4記載の有機防錆剤を表記の種々の濃度になるように添加した試験液を作成した。そして、これら試験液を用いて既述の〔防錆性〕の項と同様の方法及び評価によって防錆効果を調べたところ、両混合液A,Bのいずれの水希釈液でも後記表4に示す同じ結果が得られた。なお、有機防錆剤濃度20ppm は混合液A,B(原液)での濃度0.4%に相当する。
[Concentration of organic rust inhibitor and rust prevention effect]
Next, the following mixed liquids A and B are prepared, and water is added to these mixed liquids A and B to form 200-fold volume water dilutions, respectively. Test solutions were prepared in which the agent was added at various concentrations as indicated. And when these rust preventive effects were investigated by the same method and evaluation as the above-mentioned [rust prevention] section using these test liquids, both water-mixed liquids of both mixed liquids A and B are shown in Table 4 below. The same results shown were obtained. An organic rust inhibitor concentration of 20 ppm corresponds to a concentration of 0.4% in the mixed solutions A and B (stock solution).
混合液A・・・カプリン酸モノグリセリド4%、カプリル酸モノグリセリド4%、エタノール35%、水57%。
混合液B・・・カプリン酸モノグリセリド4%、ショ糖ラウリン酸エステル4%、エタノール35%、水57%。
Mixture A: capric acid monoglyceride 4%, caprylic acid monoglyceride 4%,
Mixture B: capric acid monoglyceride 4%, sucrose laurate 4%,
上表で示すように、各有機防錆剤は5ppm 以上(原液濃度として0.1%以上)の濃度で防錆作用が発現している。そして、良好な防錆作用を得るには、安息香酸ナトリウム及びポリリジンで10ppm 以上、アルギニンで15ppm 以上が好ましいことが判る。なお、これら有機防錆剤の配合量の上限は特に制約されないが、表で示すように30ppm 以下の極低濃度で良好な防錆性が得られるから、経済性面より乾燥前処理剤の原液中濃度で5%以下とするのがよい。 As shown in the above table, each organic rust inhibitor exhibits a rust preventive action at a concentration of 5 ppm or more (stock solution concentration of 0.1% or more). And in order to obtain a favorable rust preventive action, it is understood that 10 ppm or more is preferable for sodium benzoate and polylysine, and 15 ppm or more for arginine. In addition, although the upper limit of the compounding amount of these organic rust preventive agents is not particularly limited, as shown in the table, since a good rust preventive property can be obtained at an extremely low concentration of 30 ppm or less, a stock solution of a drying pretreatment agent from the economical aspect. The medium concentration should be 5% or less.
〔安全性試験〕
前記実施例1で調製した乾燥前処理剤(原液及び水希釈液)について、種々の安全性試験を行った結果を表5に示す。この表5から明らかなように、本発明の乾燥前処理剤は高い安全性を備えており、洗浄医療器具の乾燥前処理に好適に使用できることが判る。
[Safety test]
Table 5 shows the results of various safety tests conducted on the drying pretreatment agent (stock solution and water dilution solution) prepared in Example 1. As is apparent from Table 5, it can be seen that the pre-drying treatment agent of the present invention has high safety and can be suitably used for pre-drying treatment of cleaning medical instruments.
Claims (11)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008301450A JP5280814B2 (en) | 2008-11-26 | 2008-11-26 | Cleaning medical device pre-drying treatment agent and used medical device regeneration method |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008301450A JP5280814B2 (en) | 2008-11-26 | 2008-11-26 | Cleaning medical device pre-drying treatment agent and used medical device regeneration method |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2010126754A true JP2010126754A (en) | 2010-06-10 |
JP5280814B2 JP5280814B2 (en) | 2013-09-04 |
Family
ID=42327349
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008301450A Active JP5280814B2 (en) | 2008-11-26 | 2008-11-26 | Cleaning medical device pre-drying treatment agent and used medical device regeneration method |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP5280814B2 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012087205A (en) * | 2010-10-19 | 2012-05-10 | Pilot Ink Co Ltd | Aqueous ink composition for ballpoint pen and ballpoint pen filled with the same |
JP2013018952A (en) * | 2010-09-14 | 2013-01-31 | Nof Corp | Sterilizing detergent composition |
JP2016125036A (en) * | 2015-01-08 | 2016-07-11 | 三浦工業株式会社 | Surface treatment agent and surface treatment method |
JP2016125128A (en) * | 2015-01-08 | 2016-07-11 | 三浦工業株式会社 | Surface treatment agent and surface treatment method |
EP3369440A4 (en) * | 2015-12-22 | 2019-07-24 | Lifetech Scientific (Shenzhen) Co., Ltd. | Absorbable implantable medical device made of iron-based alloy |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005006831A (en) * | 2003-06-18 | 2005-01-13 | Dainippon Jochugiku Co Ltd | Total amount spraying aerosol type bactericide |
JP2008530279A (en) * | 2005-02-15 | 2008-08-07 | シキャン リミテッド | Anticorrosive detergent compositions and their use in cleaning dental and medical instruments |
JP2008255045A (en) * | 2007-04-04 | 2008-10-23 | Lion Corp | Germicidal agent composition and germicidal method |
-
2008
- 2008-11-26 JP JP2008301450A patent/JP5280814B2/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005006831A (en) * | 2003-06-18 | 2005-01-13 | Dainippon Jochugiku Co Ltd | Total amount spraying aerosol type bactericide |
JP2008530279A (en) * | 2005-02-15 | 2008-08-07 | シキャン リミテッド | Anticorrosive detergent compositions and their use in cleaning dental and medical instruments |
JP2008255045A (en) * | 2007-04-04 | 2008-10-23 | Lion Corp | Germicidal agent composition and germicidal method |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013018952A (en) * | 2010-09-14 | 2013-01-31 | Nof Corp | Sterilizing detergent composition |
JP2012087205A (en) * | 2010-10-19 | 2012-05-10 | Pilot Ink Co Ltd | Aqueous ink composition for ballpoint pen and ballpoint pen filled with the same |
JP2016125036A (en) * | 2015-01-08 | 2016-07-11 | 三浦工業株式会社 | Surface treatment agent and surface treatment method |
JP2016125128A (en) * | 2015-01-08 | 2016-07-11 | 三浦工業株式会社 | Surface treatment agent and surface treatment method |
EP3369440A4 (en) * | 2015-12-22 | 2019-07-24 | Lifetech Scientific (Shenzhen) Co., Ltd. | Absorbable implantable medical device made of iron-based alloy |
Also Published As
Publication number | Publication date |
---|---|
JP5280814B2 (en) | 2013-09-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5280814B2 (en) | Cleaning medical device pre-drying treatment agent and used medical device regeneration method | |
JP5407002B2 (en) | Cleaning composition for medical instrument washer | |
TWI485244B (en) | Low foaming cleaner | |
WO2012024680A1 (en) | Rust removing composition | |
JP2009144070A (en) | Detergent composition for medical appliance | |
JP6083616B2 (en) | Car air conditioner cleaning agent and aerosol container for cleaning car air conditioner filled with the same | |
JP2008530279A (en) | Anticorrosive detergent compositions and their use in cleaning dental and medical instruments | |
JP2010235801A (en) | Cleaner composition | |
JP5364396B2 (en) | Cleaning composition for wiping and cleaning method | |
JP6281144B2 (en) | Cleaning composition for car air conditioner and aerosol composition using the same | |
JP5930631B2 (en) | Disinfectant composition | |
JP6203508B2 (en) | Fungicide | |
JP4187449B2 (en) | Car air conditioner cleaner | |
JP4368162B2 (en) | Liquid detergent composition for cooking equipment | |
JP6361511B2 (en) | Surface treatment agent and surface treatment method | |
WO1999053003A1 (en) | Cleaning chemical composition | |
JP5513836B2 (en) | Water-soluble cleaning solution | |
JP4811985B2 (en) | Aqueous antibacterial detergent | |
JP2019052277A (en) | Detergent composition stock solution and detergent composition containing the detergent composition stock solution | |
JP2003081709A (en) | Bactericidal disinfectant composition and bactericidal disinfectant material | |
JP2017124076A (en) | Liquid deodorant composition | |
JP2007074990A (en) | Sterilizer | |
JP6087255B2 (en) | Preparation method of temper rolling liquid | |
JP2014031334A (en) | Ethanol preparation | |
JP5827650B2 (en) | Water-soluble cleaning solution |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20100623 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20121011 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20121017 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20121211 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20130501 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20130523 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 Ref document number: 5280814 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |