JP2010064997A - 貼付材並びに貼付製剤 - Google Patents
貼付材並びに貼付製剤 Download PDFInfo
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- JP2010064997A JP2010064997A JP2008234604A JP2008234604A JP2010064997A JP 2010064997 A JP2010064997 A JP 2010064997A JP 2008234604 A JP2008234604 A JP 2008234604A JP 2008234604 A JP2008234604 A JP 2008234604A JP 2010064997 A JP2010064997 A JP 2010064997A
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- Prior art keywords
- adhesive layer
- patch
- pressure
- sensitive adhesive
- weight
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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Abstract
【解決手段】架橋反応可能な官能基を分子内に有する液状ゴムを33重量%〜65重量%含有する組成物より成り、ゲル分率が50重量%〜75重量%である粘着剤層を、支持体の少なくとも一方の面に層状に形成させる。
【選択図】なし
Description
(1)皮膚接着性:貼付材等が所定期間皮膚面から剥離することなく、貼付状態が保持される必要があるからである。
(2)剥離性:粘着剤層には、上記のように皮膚接着性が求められるが、使用後に皮膚から貼付材等を除去する際、接着性が強すぎて剥離性が悪いと、剥離の際に痛みを感じさせたり、皮膚面に粘着剤層が残留して糊残りを感じさせたりするからである。
(3)低刺激性:粘着剤層の皮膚に対する刺激性が強いと、皮膚かぶれを誘発するからである。
(4)皮膚変形に対する追従性:皮膚の患部や創傷面の保護効果、薬剤経皮吸収効果を十分に発揮させるためには、貼付材等が身体の動きに伴う皮膚変形によっても接着性を失うことのないように、粘着剤層がかかる皮膚変形に対して十分追従し得るものであることを要するからである。
[1]架橋反応可能な官能基を分子内に有する液状ゴムを33重量%〜65重量%含有する組成物より成り、且つゲル分率が50重量%〜75重量%である粘着剤層を、支持体の少なくとも一方の面に層状に形成して成る、貼付材。
[2]粘着剤層が、さらに有機液状成分を10重量%〜40重量%含有する組成物より成ることを特徴とする、上記[1]に記載の貼付材。
[3]架橋反応可能な官能基を分子内に有する液状ゴムが、架橋反応可能な官能基を分子内に有する液状イソプレンゴムであることを特徴とする、上記[1]又は[2]の貼付材。
[4]有機液状成分が、油脂類、炭化水素類、脂肪酸エステル類及び高級脂肪酸類より選択される1種又は2種以上であることを特徴とする、上記[2]又は[3]の貼付材。
[5]脂肪酸エステル類が、脂肪酸モノアルキルエステル類であることを特徴とする、上記[4]の貼付材。
[6]脂肪酸モノアルキルエステル類が、ミリスチン酸イソプロピル及びパルミチン酸イソプロピルから選択される1種又は2種であることを特徴とする、上記[5]の貼付材。
[7]粘着剤層が、さらに粘着付与剤を15重量%〜45重量%含有する組成物より成るをことを特徴とする、上記[1]〜[6]のいずれか1項に記載の貼付材。
[8]粘着剤層の厚さが40μm以上であることを特徴とする、上記[1]〜[7]のいずれか1項に記載の貼付材。
[9]上記[1]〜[8]のいずれかに記載の貼付材において、粘着剤層が薬剤を含有して成る、貼付製剤。
(分析条件)
ゲルろ過クロマトグラフィー装置:HLC8120(東ソー株式会社製)
カラム:TSKgelGMH−H(S)(東ソー株式会社製)
標準:ポリスチレン
溶離液:テトラヒドロフラン
流速:0.5ml/分
測定温度:40℃
検出手段:示差屈折計
ゲル分率(重量%)=W2/(W1×A/B)×100
A:分子内に架橋反応可能な官能基を有する液状ゴム及び架橋剤の重量
B:粘着剤層の総重量
W1:粘着剤層より採取した試料の重量
W2:粘着剤層より採取した試料をトルエンに浸漬して得られる不溶分の重量
ゲル分率(重量%)=W2/(W1×A/B)×100
A:カルボキシル化液状ポリイソプレン及びTETRAD−Cの重量
B:カルボキシル化液状ポリイソプレン、ミリスチン酸イソプロピル、脂環族炭化水素樹脂及びTETRAD−Cの総重量
23℃、相対湿度65%の恒温室内にて、実施例及び比較例の各試料を長さ50mm×幅12mmに打ち抜き、試験片とした。この恒温室内で、各試験片より剥離ライナーを剥離して粘着面を露出させ、2kgゴムローラーを一往復させ、試験片の粘着面をベークライト板に貼付した。30分間静置した後、引張試験機(Autograph AG−IS(島津製作所製))により180°の剥離(剥離速度300mm/min)時における最大応力を測定した。
本試験においては、上記表1に示す組成の粘着剤層調製用液を上記と同じ剥離ライナー上に乾燥後の厚さが100μmになるように塗布し、100℃で5分間乾燥機にて乾燥後、粘着面に同じ材質の剥離ライナーを貼り合わせて、シート状の貼付材を調製した。この貼付材を幅20mm、長さ40mmの矩形に切断して試料とした。次いで、前記試料の長辺側からその長辺を中心軸として密に巻き、円柱状ないし棒状の試験片を得た。得られた各試験片について、23℃、相対湿度65%の条件下に、引張試験機(Autograph AG−IS(島津製作所製))にて、チャック間距離を20mm(つかみしろ各10mm)に設定し、引張強度300mm/minで引張力(N)を測定し、得られた結果から100%モジュラスの応力を求め、その値を柔軟性の指標とした。
日本工業規格(JIS)Z0237に従い、次の通り試験を行った。ただし、本試験においては、試料の都合上、実施例及び比較例のそれぞれを幅50mm×長さ50mmに打ち抜いたものを試験片とした。すなわち、23℃、相対湿度65%の条件下に、試験片をその粘着面が露出されるように傾斜角30°の球転装置上に設置し、試験片と助走部との間に段差が生じないように固定した。次いで、試験片上を異なる球径のボールを転がし、5秒以上静止した際の最大球径を当該試験片のボールタック値とした。
実施例及び比較例の各試料を、幅12mm×長さ50mmに打ち抜き、試験片とした。試験片より剥離ライナーを剥離して粘着面を露出させ、皮膚面に24時間貼付し、剥離した後の皮膚の状態を下記評価基準に従って評価した。
評価基準:
◎;貼付前と全く変わらず、べたつき感はない。
○;皮膚にややべたつき感がある。
△;皮膚に粘着剤が一部転写されている。
×;皮膚全面に粘着剤が残存している。
Claims (9)
- 架橋反応可能な官能基を分子内に有する液状ゴムを33重量%〜65重量%含有する組成物より成り、且つゲル分率が50重量%〜75重量%である粘着剤層を、支持体の少なくとも一方の面に層状に形成して成る、貼付材。
- 粘着剤層が、さらに有機液状成分を10重量%〜40重量%含有する組成物より成ることを特徴とする、請求項1に記載の貼付材。
- 架橋反応可能な官能基を分子内に有する液状ゴムが、架橋反応可能な官能基を分子内に有する液状イソプレンゴムであることを特徴とする、請求項1又は請求項2に記載の貼付材。
- 有機液状成分が、油脂類、炭化水素類、脂肪酸エステル類及び高級脂肪酸類より選択される1種又は2種以上であることを特徴とする、請求項2又は請求項3に記載の貼付材。
- 脂肪酸エステル類が、脂肪酸モノアルキルエステル類であることを特徴とする、請求項4に記載の貼付材。
- 脂肪酸モノアルキルエステル類が、ミリスチン酸イソプロピル及びパルミチン酸イソプロピルから選択される1種又は2種であることを特徴とする、請求項5に記載の貼付材。
- 粘着剤層が、さらに粘着付与剤を15重量%〜45重量%含有する組成物より成ることを特徴とする、請求項1〜請求項6のいずれか1項に記載の貼付材。
- 粘着剤層の厚さが40μm以上であることを特徴とする、請求項1〜請求項7のいずれか1項に記載の貼付材。
- 請求項1〜請求項8のいずれか1項に記載の貼付材において、粘着剤層が薬剤を含有して成る、貼付製剤。
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008234604A JP5243158B2 (ja) | 2008-09-12 | 2008-09-12 | 貼付材並びに貼付製剤 |
US12/585,315 US20100068248A1 (en) | 2008-09-12 | 2009-09-11 | Patch and patch preparation |
CA002678344A CA2678344A1 (en) | 2008-09-12 | 2009-09-11 | Patch and patch preparation |
CN2009101759653A CN101669924B (zh) | 2008-09-12 | 2009-09-11 | 贴剂和贴剂制剂 |
EP09252171.5A EP2163267B1 (en) | 2008-09-12 | 2009-09-11 | Patch and patch preparation |
KR1020090085837A KR20100031485A (ko) | 2008-09-12 | 2009-09-11 | 패치 및 패치 제제 |
Applications Claiming Priority (1)
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JP2008234604A JP5243158B2 (ja) | 2008-09-12 | 2008-09-12 | 貼付材並びに貼付製剤 |
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JP2010064997A true JP2010064997A (ja) | 2010-03-25 |
JP5243158B2 JP5243158B2 (ja) | 2013-07-24 |
Family
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JP2008234604A Expired - Fee Related JP5243158B2 (ja) | 2008-09-12 | 2008-09-12 | 貼付材並びに貼付製剤 |
Country Status (6)
Country | Link |
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US (1) | US20100068248A1 (ja) |
EP (1) | EP2163267B1 (ja) |
JP (1) | JP5243158B2 (ja) |
KR (1) | KR20100031485A (ja) |
CN (1) | CN101669924B (ja) |
CA (1) | CA2678344A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012031071A (ja) * | 2010-07-28 | 2012-02-16 | Nitto Denko Corp | 貼付剤および貼付製剤 |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CA2826003C (en) * | 2011-02-02 | 2019-01-08 | Yasuaki Okada | Blonanserin-containing patch preparation |
WO2014159798A1 (en) | 2013-03-13 | 2014-10-02 | Avery Dennison Corporation | Improving adhesive properties |
US9974754B2 (en) * | 2013-12-18 | 2018-05-22 | Maruishi Pharmaceutical Co., Ltd. | Hydrous adhesive patch |
CN108742750B (zh) * | 2018-06-21 | 2020-09-22 | 广州迈普再生医学科技股份有限公司 | 组织封堵材料及其制备方法和封堵制品 |
KR102290323B1 (ko) * | 2020-09-04 | 2021-08-18 | 주식회사 우주텍 | 아로마 패치 |
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JPS61151121A (ja) * | 1984-12-24 | 1986-07-09 | Taisho Pharmaceut Co Ltd | 貼付薬 |
JPH06145050A (ja) * | 1992-11-11 | 1994-05-24 | Sekisui Chem Co Ltd | 貼付剤の製造方法 |
JP2000230157A (ja) * | 1999-02-09 | 2000-08-22 | Nitto Denko Corp | 伸縮性粘着テープもしくはシート |
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JP2010043065A (ja) * | 2008-07-17 | 2010-02-25 | Nitto Denko Corp | 貼付剤および貼付製剤 |
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JP2700835B2 (ja) | 1989-12-28 | 1998-01-21 | 日東電工株式会社 | アクリル系ゲル材およびアクリル系ゲル製剤 |
JPH10151185A (ja) | 1996-11-21 | 1998-06-09 | Nichiban Co Ltd | 皮膚貼付用粘着テープ |
JP4358978B2 (ja) * | 2000-09-05 | 2009-11-04 | 日東電工株式会社 | 経皮吸収製剤 |
JP5192297B2 (ja) * | 2007-07-05 | 2013-05-08 | 日東電工株式会社 | 貼付剤および貼付製剤 |
JP5192296B2 (ja) * | 2007-07-05 | 2013-05-08 | 日東電工株式会社 | 貼付剤および貼付製剤 |
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2008
- 2008-09-12 JP JP2008234604A patent/JP5243158B2/ja not_active Expired - Fee Related
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2009
- 2009-09-11 US US12/585,315 patent/US20100068248A1/en not_active Abandoned
- 2009-09-11 EP EP09252171.5A patent/EP2163267B1/en not_active Not-in-force
- 2009-09-11 CA CA002678344A patent/CA2678344A1/en not_active Abandoned
- 2009-09-11 KR KR1020090085837A patent/KR20100031485A/ko not_active Application Discontinuation
- 2009-09-11 CN CN2009101759653A patent/CN101669924B/zh not_active Expired - Fee Related
Patent Citations (6)
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JPS61151121A (ja) * | 1984-12-24 | 1986-07-09 | Taisho Pharmaceut Co Ltd | 貼付薬 |
JPH06145050A (ja) * | 1992-11-11 | 1994-05-24 | Sekisui Chem Co Ltd | 貼付剤の製造方法 |
JP2000230157A (ja) * | 1999-02-09 | 2000-08-22 | Nitto Denko Corp | 伸縮性粘着テープもしくはシート |
JP2008162975A (ja) * | 2006-12-28 | 2008-07-17 | Lion Corp | 非水系温感粘着剤組成物および温感貼付剤 |
JP2009242254A (ja) * | 2008-03-28 | 2009-10-22 | Lintec Corp | 経皮吸収貼付剤 |
JP2010043065A (ja) * | 2008-07-17 | 2010-02-25 | Nitto Denko Corp | 貼付剤および貼付製剤 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2012031071A (ja) * | 2010-07-28 | 2012-02-16 | Nitto Denko Corp | 貼付剤および貼付製剤 |
Also Published As
Publication number | Publication date |
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US20100068248A1 (en) | 2010-03-18 |
EP2163267A2 (en) | 2010-03-17 |
JP5243158B2 (ja) | 2013-07-24 |
CA2678344A1 (en) | 2010-03-12 |
CN101669924A (zh) | 2010-03-17 |
KR20100031485A (ko) | 2010-03-22 |
EP2163267B1 (en) | 2013-11-06 |
EP2163267A3 (en) | 2012-03-07 |
CN101669924B (zh) | 2013-05-29 |
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