JP2009509138A - 多次元クロマトグラフィー装置および方法 - Google Patents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
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- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/46—Flow patterns using more than one column
- G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
- G01N30/463—Flow patterns using more than one column with serial coupling of separation columns for multidimensional chromatography
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
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- G01—MEASURING; TESTING
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- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/46—Flow patterns using more than one column
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/46—Flow patterns using more than one column
- G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
- G01N30/462—Flow patterns using more than one column with serial coupling of separation columns with different eluents or with eluents in different states
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- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/46—Flow patterns using more than one column
- G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
- G01N30/465—Flow patterns using more than one column with serial coupling of separation columns with specially adapted interfaces between the columns
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/46—Flow patterns using more than one column
- G01N30/468—Flow patterns using more than one column involving switching between different column configurations
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- G—PHYSICS
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- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
- G01N2030/965—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange suppressor columns
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Abstract
【選択図】図1
Description
Claims (24)
- イオンクロマトグラフィー装置であって、
(a)液体試料の流れの中の1つの正または負の電荷のイオン種を分離する第1分離媒質を含有する第1流入室を画定する第1筐体と、
(b)液体試料の流れの中のイオン種を分離する前記第1分離媒質と同じ電荷の第2分離媒質を含有する第2流入室を画定する第2筐体であって、前記第2室は前記第1室の体積の0.9倍以下の体積を有する第2筐体と、
(c)さらなる分析のためにイオン種を第1室から第2室へ選択的に移送することを可能にするように構成される、前記第1室と前記第2室との間に配置される第1バルビングと、
を備える前記装置。 - (d)前記第1室の下流であるが、前記第2室の上流にある第1流入室と流体連通する第1サプレッサをさらに備える請求項1記載の装置。
- (e)前記第1サプレッサの下流であるが、前記第2室の上流に配置される第1検出器をさらに備える請求項2記載の装置。
- 前記第1サプレッサが、前記第1室と流体連通する液体試料流路を第1再生流路から分離する膜を備える膜サプレッサであり、前記装置が、
(f)前記第1検出器と前記第1再生流路との間の第1流体管
をさらに備える請求項3記載の装置。 - 前記第2流入室の下流にあり、それと流体連通する第2検出器をさらに備える請求項3記載の装置。
- (f)前記第2室と前記第2検出器との間に配置される第2サプレッサ
をさらに備える請求項5記載の装置。 - 前記第2サプレッサが、前記第2室と流体連通する液体試料流路を第2再生流路から分離する膜を備える膜サプレッサであり、前記装置が、
(f)前記第2検出器と前記第2再生流路との間の流体管
をさらに備える請求項6記載の装置。 - (d)前記弁に配置され、それと流体連通する流入イオン種濃縮器
をさらに備える請求項1記載の装置。 - (e)前記第1流入室と前記濃縮カラムとの間に配置されるガス除去デバイス
をさらに備える請求項8記載の装置。 - 前記バルビングが、前記第1室からの液体流が前記濃縮器と流体連通する第1位置と、前記第1室からの液体流が前記濃縮器を迂回する第2位置とを有する請求項8記載の装置。
- 前記第1室を通して液体をくみ上げる第1ポンプを前記第1室の上流にさらに備える請求項1記載の装置。
- 前記第2室を通して液体をくみ上げる第2ポンプを前記第1室の下流であるが、前記第2室の上流にさらに備える請求項11記載の装置。
- (d)前記第1室の上流側と流体連通する電解溶離液生成器
をさらに備える請求項1記載の装置。 - イオンクロマトグラフィー装置であって、
(a)液体試料の流れの中の1つの正または負の電荷のイオン種を分離する第1分離媒質を含有する第1流入室を画定する第1筐体と、
(b)液体試料の流れの中のイオン種を分離する前記第1分離媒質と同じ電荷の第2分離媒質を含有する第2流入室を画定する第2筐体であって、前記第2流入室は前記第1流入室の断面積の0.9倍以下の流れに垂直な断面積を有する第2筐体と、
(c)さらなる分析のためにイオン種を第1室から第2室へ選択的に移送することを可能にするように構成される、前記第1室と前記第2室との間に配置される第1バルビングと、
を備える前記装置。 - イオンクロマトグラフィー方法であって、
(a)1つの正または負の電荷のイオン種を含有する溶離液含有液体試料流を第1流入室内の第1分離媒質を通して流して、前記イオン種を分離する工程と、
(b)前記第1分離媒質、および第2流入室内の前記第1分離媒質同じ正または負の電荷の第2分離媒質からの前記分離イオン種の選択された部分とともに溶離液を流して、前記イオン種をさらに分離する工程であって、前記第2分離媒質を通る体積流量が前記第1分離媒質を通る体積流量の0.9倍以下である工程と、
(c)第1流入検出器で、前記第2分離媒質から出る水性液体中の別の分離イオン種を検出する工程と、
を含む前記方法。 - (d)前記第1室から出た後、前記第2室に流入する前に、前記液体試料の流れの中の溶離液の電導度を抑制する工程
をさらに含む請求項15記載の方法。 - 前記抑制が、前記液体試料の流れと連通する液体試料流路と再生流路を分離する選択透過性膜を備える膜サプレッサで実行される請求項16記載の方法であって、
(e)前記第1分離室から出る前記試料の流れの中のイオン種を、前記第2室に流入する前に第2流入検出器で検出する工程と、
(f)前記第2検出器を出る前記液体試料の流れの少なくとも一部を前記再生流路を通して流す工程と、
をさらに含む前記方法。 - (d)前記試料の流れを濃縮器内のイオン種濃縮媒質を通して流すことによって、前記第1分離室から出る前記試料の流れの中の前記イオン種を、前記第2室に流入する前に濃縮する工程
をさらに含む請求項15記載の方法。 - (e)工程(d)中に、前記濃縮媒質から出る水性溶液を、前記液体試料の流れと連通する液体試料流路と再生流路を分離する選択透過性膜を備える膜サプレッサ内の再生流路へ流す工程
をさらに含む請求項18記載の方法。 - (d)前記第2室から出る前記試料の流れの中の溶離液の電導度を抑制する工程
をさらに含む請求項15記載の方法。 - 前記抑制が、前記第2室から出る前記液体試料の流れと連通する液体試料流路と再生流路を分離する選択透過性膜を備える膜サプレッサで実行される請求項20記載の方法であって、
(e)前記第2室から出る前記液体試料の流れの少なくとも一部を前記再生流路を通して流す工程
をさらに含む前記方法。 - 前記第2流入室が前記第1流入室の体積の0.9倍以下の体積を有する請求項15記載の方法。
- 流れに垂直な前記第2流入室の断面積が前記第1流入室の断面積の0.9倍以下である請求項15記載の方法。
- 前記溶離液が二酸化炭素ガスを含む請求項18記載の方法であって、
(e)二酸化炭素ガスを前記試料の流れから前記濃縮カラムの下流で除去する工程
をさらに含む前記方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/229,002 US8101422B2 (en) | 2005-09-16 | 2005-09-16 | Multidimensional chromatography apparatus and method |
US11/229,002 | 2005-09-16 | ||
PCT/US2006/035438 WO2007035324A1 (en) | 2005-09-16 | 2006-09-12 | Multidimensional chromatography apparatus and method |
Publications (2)
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JP2009509138A true JP2009509138A (ja) | 2009-03-05 |
JP5004958B2 JP5004958B2 (ja) | 2012-08-22 |
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Application Number | Title | Priority Date | Filing Date |
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JP2008531242A Active JP5004958B2 (ja) | 2005-09-16 | 2006-09-12 | 多次元クロマトグラフィー装置および方法 |
Country Status (7)
Country | Link |
---|---|
US (1) | US8101422B2 (ja) |
EP (2) | EP1924851A1 (ja) |
JP (1) | JP5004958B2 (ja) |
KR (1) | KR101346714B1 (ja) |
AU (1) | AU2006292683B2 (ja) |
CA (1) | CA2621687C (ja) |
WO (1) | WO2007035324A1 (ja) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4679368B2 (ja) * | 2003-12-11 | 2011-04-27 | 一洋 今井 | 発現微量タンパク質/ペプチドの検出・分離・同定法 |
US7682506B2 (en) * | 2005-09-16 | 2010-03-23 | Dionex Corporation | IC system including sample pretreatment and using a single pump |
US8143071B2 (en) * | 2006-12-21 | 2012-03-27 | Phynexus, Inc. | Method and device for extracting an analyte |
WO2008150763A1 (en) * | 2007-05-29 | 2008-12-11 | Waters Investments Limited | Apparatus and methods for multidimensional analysis |
US7964411B2 (en) * | 2007-06-12 | 2011-06-21 | Dionex Corporation | Membrane based concentrators |
US9188573B2 (en) * | 2010-01-20 | 2015-11-17 | Dionex Corporation | Multichannel ion chromatography system and method |
US9086426B2 (en) * | 2012-09-12 | 2015-07-21 | Dionex Corporation | Multi-component eluent generating system and method |
CN102967681B (zh) * | 2012-11-26 | 2014-11-05 | 中国科学院青岛生物能源与过程研究所 | 一种多维离子色谱分析*** |
CN102967680B (zh) * | 2012-11-26 | 2014-12-10 | 中国科学院青岛生物能源与过程研究所 | 一种毛细管离子色谱质谱联用分析*** |
KR101359941B1 (ko) | 2013-07-10 | 2014-02-10 | 주식회사 위드텍 | 신속측정을 위한 액체 크로마토그래피 장치 |
KR101574272B1 (ko) * | 2014-08-20 | 2015-12-07 | 한국표준과학연구원 | 하트 컷 방법을 위한 이차원 액체 크로마토그래피 시스템 |
US10585071B2 (en) * | 2015-11-12 | 2020-03-10 | Michael Organ | Multidimensional peak purity analysis |
US11287403B2 (en) * | 2016-01-07 | 2022-03-29 | Board Of Regents, The University Of Texas System | Ion chromatography system and methods utilizing a weak acid or weak base extraction device |
US10948466B2 (en) * | 2017-03-03 | 2021-03-16 | Dionex Corporation | Flow control in an electrolytic reagent concentrator for ion chromatography |
CN110292956B (zh) | 2018-03-22 | 2022-12-06 | 戴安公司 | 基于交联的羟基烷基胺层和缩水甘油的阴离子交换固定相 |
CN112074723A (zh) * | 2018-04-30 | 2020-12-11 | 安捷伦科技有限公司 | 具有压力调节的多维样品分离 |
US11307181B1 (en) | 2018-07-14 | 2022-04-19 | Sielc Technologies Corporation | HPLC system with mixed-mode columns for measuring charged analytes in complex mixtures |
EP3910329A1 (en) * | 2020-05-14 | 2021-11-17 | LG Chem, Ltd. | On-line system for improving detection level of analytes by liquid chromatography and analysis method using same |
US20210404998A1 (en) * | 2020-06-29 | 2021-12-30 | Michael Organ | Apparatus and methods for multidimensional chromatography analysis |
US20220113287A1 (en) * | 2020-10-09 | 2022-04-14 | Srivatsan Mohana Rangan | Methods for simultaneous quantification of anions using ion chromatography and suppressed ion conductivity |
US11733218B2 (en) * | 2021-09-08 | 2023-08-22 | Dionex Corporation | Automated valve switching setup for ion chromatography (IC) that facilitates equilibration of consumables or allows for normal IC operation |
US20230075933A1 (en) * | 2021-09-09 | 2023-03-09 | Dionex Corporation | Check standard recycle setup for ion chromatography |
CN114113373B (zh) * | 2021-11-09 | 2023-12-26 | 东南大学 | 一种测定尿液中草甘膦、草铵膦和亚硝酸盐的***和方法 |
US11860143B2 (en) * | 2021-12-21 | 2024-01-02 | Dionex Corporation | Method and system for self-regulating a suppressor |
KR20240002343A (ko) | 2022-06-29 | 2024-01-05 | 신동호 | 숙성을 겸한 떡찜기 |
CN116203167B (zh) * | 2023-04-27 | 2023-08-01 | 广东省农业科学院蚕业与农产品加工研究所 | 一种循环型多维液相色谱分离***及其应用 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55138654A (en) * | 1979-04-12 | 1980-10-29 | Dionex Corp | Apparatus for and method of combining chromatography separation and quantative analysis of varied ions |
JPS56162050A (en) * | 1980-04-22 | 1981-12-12 | Dionex Corp | Liquid chromatography and method of using ion condensation |
JPS6156969A (ja) * | 1984-08-28 | 1986-03-22 | Yokogawa Hokushin Electric Corp | 有機酸・無機陰イオンの分析方法およびその装置 |
JPH0518948A (ja) * | 1990-02-13 | 1993-01-26 | Dionex Corp | 高純度クロマトグラフイー溶離液を発生させる方法及び装置 |
JPH05281215A (ja) * | 1992-02-10 | 1993-10-29 | Dionex Corp | イオン分析のための装置及び方法 |
JP2001194353A (ja) * | 1999-10-13 | 2001-07-19 | Alltech Associates Inc | 試料の検出に先立ってガスを除去するイオンクロマトグラフィー装置及び方法 |
JP2004101477A (ja) * | 2002-09-12 | 2004-04-02 | Yoshio Yamauchi | 2次元高速液体クロマトグラフ装置及びそれを用いた蛋白質分析装置 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5248426A (en) * | 1992-02-10 | 1993-09-28 | Dionex Corporation | Ion chromatography system using electrochemical suppression and detector effluent recycle |
US6225129B1 (en) | 1998-02-02 | 2001-05-01 | Dionex Corporation | Large capacity acid or base generation apparatus and method of use |
-
2005
- 2005-09-16 US US11/229,002 patent/US8101422B2/en not_active Expired - Fee Related
-
2006
- 2006-09-12 KR KR1020087009108A patent/KR101346714B1/ko active IP Right Grant
- 2006-09-12 EP EP06803403A patent/EP1924851A1/en not_active Withdrawn
- 2006-09-12 JP JP2008531242A patent/JP5004958B2/ja active Active
- 2006-09-12 WO PCT/US2006/035438 patent/WO2007035324A1/en active Application Filing
- 2006-09-12 EP EP18199722.2A patent/EP3486647B1/en active Active
- 2006-09-12 AU AU2006292683A patent/AU2006292683B2/en not_active Ceased
- 2006-09-12 CA CA2621687A patent/CA2621687C/en active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55138654A (en) * | 1979-04-12 | 1980-10-29 | Dionex Corp | Apparatus for and method of combining chromatography separation and quantative analysis of varied ions |
JPS56162050A (en) * | 1980-04-22 | 1981-12-12 | Dionex Corp | Liquid chromatography and method of using ion condensation |
JPS6156969A (ja) * | 1984-08-28 | 1986-03-22 | Yokogawa Hokushin Electric Corp | 有機酸・無機陰イオンの分析方法およびその装置 |
JPH0518948A (ja) * | 1990-02-13 | 1993-01-26 | Dionex Corp | 高純度クロマトグラフイー溶離液を発生させる方法及び装置 |
JPH05281215A (ja) * | 1992-02-10 | 1993-10-29 | Dionex Corp | イオン分析のための装置及び方法 |
JP2001194353A (ja) * | 1999-10-13 | 2001-07-19 | Alltech Associates Inc | 試料の検出に先立ってガスを除去するイオンクロマトグラフィー装置及び方法 |
JP2004101477A (ja) * | 2002-09-12 | 2004-04-02 | Yoshio Yamauchi | 2次元高速液体クロマトグラフ装置及びそれを用いた蛋白質分析装置 |
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CA2621687C (en) | 2015-02-10 |
JP5004958B2 (ja) | 2012-08-22 |
US8101422B2 (en) | 2012-01-24 |
CA2621687A1 (en) | 2007-03-29 |
EP3486647B1 (en) | 2023-01-25 |
AU2006292683A1 (en) | 2007-03-29 |
KR20080059217A (ko) | 2008-06-26 |
AU2006292683B2 (en) | 2012-03-08 |
WO2007035324A1 (en) | 2007-03-29 |
EP1924851A1 (en) | 2008-05-28 |
EP3486647A1 (en) | 2019-05-22 |
US20070065343A1 (en) | 2007-03-22 |
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