JP2008515598A - 管腔内治療パッチ - Google Patents
管腔内治療パッチ Download PDFInfo
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- JP2008515598A JP2008515598A JP2007536774A JP2007536774A JP2008515598A JP 2008515598 A JP2008515598 A JP 2008515598A JP 2007536774 A JP2007536774 A JP 2007536774A JP 2007536774 A JP2007536774 A JP 2007536774A JP 2008515598 A JP2008515598 A JP 2008515598A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/958—Inflatable balloons for placing stents or stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0057—Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
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- Heart & Thoracic Surgery (AREA)
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Abstract
Description
本発明は、治療的送達に関する。より具体的には、本発明は、患者の体内の標的部位に治療薬を送達し、次いで治療薬を標的部位に配置すること、ここで、治療薬は配置可能なパッチを有する標的部位に運ばれる、による治療薬の送達に関する。
患者の体内の標的部位又は領域への治療薬の送達は、現代医学で通常反復される手段である。現代的な治療送達技術は、身体の外側で行われる皮下注射から、患者の体内の深くのインプラント設置に至まであり得る。想像できるように、前者は、実際上、非-侵襲的であるが、後者の方法は侵襲性が高い。
本発明は、治療薬を送達するための装置、方法及び用具を含む。本発明に従う装置は、管腔内に適合する大きさの管腔内パッチ、及び膨張可能な治療薬送達装置を含む。本実施態様におけるパッチは、露出表面上に粘着部位、及び露出表面と一体となった薬物リザーバー部位を有してもよい。比較すると、本発明を採用する方法は、膨張可能な送達装置上に管腔内パッチを置き;送達装置及び膨張可能なパッチを標的部位に前進させ;標的部位にパッチが粘着するように送達装置を膨張させ;及び送達装置を伸縮すること、を含むことができる。そうすることにおいて、パッチは、持続期間中、標的部位に治療薬を放出し続けることができる。
図1は、本発明の実施態様に従う治療送達装置107である。図1の送達装置107において、管腔内パッチ102は、送達カテーテル100の膨張可能なバルーン101上に置かれる。管腔内パッチ102は、バルーンが標的部位の近傍に位置付けられ、次いで膨張されるときに、標的部位に対して押し付けることができるように、送達装置107に位置合わせをすることができる。標的部位上に一旦押し付けられると、管腔内パッチは、治療薬を送達するためにそこに残ってもよく、望ましくない出血を止めてもよく又は他の所望の機能を果たしてもよい。管腔内パッチ102は、標的部位にパッチ102を固定するために粘着剤を含んでもよい。この粘着は、好ましくは、パッチ102を標的部位に堅く固定するために十分に強力であり、部分的出血を遅らせ又は止め、同時に短時間又は長時間、当該部位に治療薬を送達することもする。粘着剤は、パッチの末端に沿ってパッチ上に置いてもよく、その表面の他の部分上に置いてもよい。粘着剤は、パッチ上に加えられた力の量がパッチと標的部位との粘着力に影響を与えるので、感圧性である。パッチが標的部位に対して位置付けられ粘着されるので、膨張可能バルーンによりパッチ上に加えられた力は、標的部位においてパッチを位置付けるように働くだけでなく、パッチ102の背後から残りの体液を流出させるように働くことができる。
パッチの層は、Repka等の米国特許第6,375,963号明細書及びDunba等の米国特許第6,162,456号明細書に開示されているヒドロキシプロピルセルロース又はポリエチレンオキシドから形成することもできる。
Claims (18)
- 少なくとも1つの粘着部位及び少なくとも1つの治療リザーバー部位を含む管腔内パッチ、ここで、当該パッチは、ヒトの管腔内に適合するような大きさであり、当該粘着部位は当該パッチの露出面上にある;及び
膨張可能なバルーンを有する膨張可能な送達用具、ここで、当該管腔内パッチは当該膨張可能なバルーン上に配置される、
を含む治療送達装置。 - 前記管腔内パッチの少なくとも1つの部位が水に溶解性である、請求項1記載の治療送達装置。
- 前記管腔内パッチが少なくとも1つの保護部位を更に含み、当該保護部位が前記粘着部位を覆う、請求項1記載の治療送達装置。
- 前記管腔内パッチの少なくとも1つの部位が、予め設定された割合で溶解する、請求項1記載の治療送達装置。
- 前記管腔内パッチが少なくとも1つの支持部位を更に含み、当該支持部位が当該パッチに更なる強度を提供する、請求項1記載の治療送達装置。
- 前記管腔内パッチの少なくとも1つの部位が、成長中の細胞のための多孔性ポリマー基材から形成される、請求項1記載の治療送達装置。
- 前記管腔内パッチの少なくとも1つの部位が、その温度によって変動する軟度を有する記憶プラスチックである、請求項1記載の治療送達装置。
- 前記管腔パッチが、前記バルーン上に配置されるときに、折り畳まれる、請求項1記載の治療送達装置。
- 前記バルーンが複数のマイクロオリフィスを特徴付ける、請求項1記載の治療送達装置。
- 薬物部位からの薬物の放出が放出制御剤により影響される、請求項1記載の治療送達装置。
- カテーテル上にスライド可能に配置された鞘を更に含み、当該鞘は、管腔内パッチ上をスライドするように位置付けられる、請求項1記載の治療送達装置。
- 前記パッチの少なくとも1つの部位がポリマーから形成される、請求項1記載の治療送達装置。
- 前記粘着部位が感圧粘着剤から形成される、請求項1記載の治療送達装置。
- 以下のステップ:
管腔内パッチを膨張可能な送達装置上に置き、当該膨張可能な送達装置は、伸縮位置を有する;
当該送達装置を標的部位に前進させ;
当該パッチが当該標的部位に粘着するように当該送達装置を膨張させ;
当該パッチを有する周囲の部位から、当該標的部位を離し;
当該送達装置を収縮そして後退させ、当該標的部位に当該パッチを留置し;及び
持続期間中、当該標的部位に当該管腔内パッチから薬物を放出すること
を含む、治療薬の送達方法。 - 前記標的部位からの水分を前記管腔内パッチへ吸収することを更に含む、請求項14記載の方法。
- 前記標的での送達の前に前記管腔内パッチを覆うように、カテーテルの遠心端上にスライド可能に配置されている鞘をスライドし;及び
当該鞘を近くにスライドすることにより、前記管腔内パッチを前記標的部位に露出すること、
を更に含む、請求項14記載の方法。 - 以下のステップ:
複数の部位を有する管腔パッチを標的部位に送達し;
当該管腔パッチを標的部位に結合させ;
水分を当該管腔パッチに吸収させ;及び
当該水分が当該管腔パッチにより吸収されるとき、当該管腔パッチから当該標的部位に薬物を放出すること
を含む、治療薬の送達方法。 - 前記管腔内パッチの少なくとも1つの部位を溶解することを更に含む、請求項17記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/962,689 | 2004-10-13 | ||
US10/962,689 US7402172B2 (en) | 2004-10-13 | 2004-10-13 | Intraluminal therapeutic patch |
PCT/US2005/036343 WO2006044308A1 (en) | 2004-10-13 | 2005-10-12 | Intraluminal therapeutic patch |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2008515598A true JP2008515598A (ja) | 2008-05-15 |
JP5210635B2 JP5210635B2 (ja) | 2013-06-12 |
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ID=35717444
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007536774A Expired - Fee Related JP5210635B2 (ja) | 2004-10-13 | 2005-10-12 | 管腔内治療パッチ |
Country Status (5)
Country | Link |
---|---|
US (1) | US7402172B2 (ja) |
EP (1) | EP1804893B1 (ja) |
JP (1) | JP5210635B2 (ja) |
CA (1) | CA2584843A1 (ja) |
WO (1) | WO2006044308A1 (ja) |
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KR20200028391A (ko) | 2017-06-12 | 2020-03-16 | 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 | 세포 생착용 패치 이식편 조성물 |
IT201900006983A1 (it) | 2019-05-20 | 2020-11-20 | Fabiana Arduini | Nuovi elettrodi per la misura del pH, integrati in dispositivi medici, utile per monitorare la presenza di infezioni. |
CN111938877B (zh) * | 2020-08-17 | 2024-06-21 | 中南大学湘雅医院 | 一种关节旷置假体 |
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2005
- 2005-10-12 WO PCT/US2005/036343 patent/WO2006044308A1/en active Application Filing
- 2005-10-12 EP EP05812070.0A patent/EP1804893B1/en not_active Not-in-force
- 2005-10-12 JP JP2007536774A patent/JP5210635B2/ja not_active Expired - Fee Related
- 2005-10-12 CA CA002584843A patent/CA2584843A1/en not_active Abandoned
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Also Published As
Publication number | Publication date |
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EP1804893B1 (en) | 2016-08-10 |
EP1804893A1 (en) | 2007-07-11 |
CA2584843A1 (en) | 2006-04-27 |
US20060079957A1 (en) | 2006-04-13 |
WO2006044308A1 (en) | 2006-04-27 |
JP5210635B2 (ja) | 2013-06-12 |
US7402172B2 (en) | 2008-07-22 |
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