JP2008069134A - Composition for slimming body - Google Patents
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- JP2008069134A JP2008069134A JP2006251572A JP2006251572A JP2008069134A JP 2008069134 A JP2008069134 A JP 2008069134A JP 2006251572 A JP2006251572 A JP 2006251572A JP 2006251572 A JP2006251572 A JP 2006251572A JP 2008069134 A JP2008069134 A JP 2008069134A
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Abstract
Description
本発明は、優れた痩身効果を発揮する、痩身用組成物に関する。 The present invention relates to a slimming composition that exhibits an excellent slimming effect.
従来より、痩身効果を目的としてカフェイン、常春ツタ抽出物、ハマメリス抽出物、緑茶抽出物、紅茶抽出物、ウーロン茶抽出物、海藻抽出物等の薬効成分が痩身用組成物に配合されている。最近では、リパーゼ活性を高め、脂質代謝を促進する効果に優れたウイキョウ抽出物を配合することを特徴とする痩身用皮膚外用剤（特許文献１参照）、ホスホジエステラーゼ抑制剤であるガラナエキスとカルニチン誘導体を含有する痩身用皮膚外用剤（特許文献２参照）、コーヒーエキスとベタイン等を含有する抗肥満剤（特許文献３参照）、マテ茶を有効成分とする糖尿病の各種の合併症を防ぐアルドースレダクターゼ阻害剤（特許文献４参照）、ショウキョウチンキを含有するゲル状温熱マッサージ料（特許文献５参照）、ミントエキスと深層水を含有する痩身効果を有する皮膚外用剤（特許文献６参照）、セイヨウキズタエキス、ヒバマタエキスとパセリ抽出物を含有する痩身用化粧料（特許文献７参照）等が知られている。 Conventionally, for the purpose of slimming effect, medicinal ingredients such as caffeine, evergreen ivy extract, hamamelis extract, green tea extract, black tea extract, oolong tea extract, seaweed extract and the like are blended in the slimming composition. Recently, a slimming skin external preparation (see Patent Document 1) characterized by containing a fennel extract that has an enhanced lipase activity and promotes lipid metabolism, and a phosphodiesterase inhibitor guarana extract and a carnitine derivative. Slimming skin external preparation (see patent document 2), anti-obesity agent (see patent document 3) containing coffee extract and betaine, and aldose reductase that prevents various complications of diabetes with mate tea as an active ingredient Inhibitor (refer to Patent Document 4), gel-like thermal massage material containing ginger tincture (refer to Patent Document 5), skin external preparation having slimming effect containing mint extract and deep water (refer to Patent Document 6), A slimming cosmetic (see Patent Document 7) containing a kizuta extract, a hibamata extract and a parsley extract is known.
しかしながら、これらの薬効成分を配合した痩身用組成物では、薬効成分の効果が十分でなかったり、あるいは、薬効を得るのに十分な量を配合すると、使用感が損なわれたり、変臭・変色など剤型の安定性に問題が有り、その改善が望まれていた。 However, slimming compositions containing these medicinal ingredients are not effective enough, or if a sufficient amount is added to obtain medicinal effects, the feeling of use may be impaired, or the odor / discoloration There was a problem in the stability of the dosage form, and the improvement was desired.
本発明者等は、上記目的を達成すべく鋭意研究を重ねた結果、血行促進剤とアミノ酸をを併用して用いることにより、上記課題を解決できることを見いだし、本発明を完成するに至った。 As a result of intensive studies to achieve the above object, the present inventors have found that the above problem can be solved by using a blood circulation promoter and an amino acid in combination, and have completed the present invention.
すなわち本発明は、血行促進剤とアミノ酸を含有する、痩身用組成物を提供する。 That is, the present invention provides a slimming composition containing a blood circulation promoter and an amino acid.
本発明の痩身用組成物の一態様においては、血行促進剤としてアンミビスナガ抽出物、サンショウ抽出物、ゲンチアナ抽出物、芥子抽出物、唐辛子抽出物、生姜抽出物、オタネニンジン抽出物、イチョウ抽出物、アルニカ抽出物、紅花抽出物、センブリ抽出物、メリロート抽出物、セイヨウトチノキ抽出物、カンフル及びその誘導体、ヒノキチオール及びその誘導体並びにそれらの塩、トコフェロール及びその誘導体、ニコチン酸及びその誘導体並びにそれらの塩、γ−オリザノール及びその誘導体、バニリルブチルエーテル、炭酸水素ナトリウムから選択される１種又は２種以上を用いる。 In one aspect of the composition for slimming of the present invention, as a blood circulation promoter, Ambibis Naga extract, salamander extract, gentian extract, eggplant extract, chili extract, ginger extract, ginseng extract, ginkgo biloba extract, Arnica extract, safflower extract, assembly extract, merirot extract, horse chestnut extract, camphor and its derivatives, hinokitiol and its derivatives and their salts, tocopherol and its derivatives, nicotinic acid and its derivatives and their salts, One or more selected from γ-oryzanol and derivatives thereof, vanillyl butyl ether, and sodium hydrogen carbonate are used.
また本発明の痩身用組成物の一態様においては、アミノ酸としてロイシン、イソロイシン、バリン、トリプトファン、リシン、メチオニン、フェニルアラニン、スレオニン、バリン、ロイシン、イソロイシン、ヒスチジン、アルギニンから選択される１種又は２種以上を用いる。 In one embodiment of the slimming composition of the present invention, the amino acid is one or two selected from leucine, isoleucine, valine, tryptophan, lysine, methionine, phenylalanine, threonine, valine, leucine, isoleucine, histidine, arginine. Use the above.
本発明によれば、優れた痩身効果を有し、皮膚外用剤、飲食物等幅広い分野で応用することが可能な、痩身用組成物を提供することができる。 ADVANTAGE OF THE INVENTION According to this invention, the composition for slimming which has the outstanding slimming effect and can be applied in wide field | areas, such as a skin external preparation and food-drinks, can be provided.
本発明の実施の形態を説明する。 An embodiment of the present invention will be described.
本発明の痩身用組成物は、血行促進剤とアミノ酸を含有する、痩身用組成物を提供する。 The slimming composition of the present invention provides a slimming composition containing a blood circulation promoter and an amino acid.
本発明の痩身用組成物において配合する血行促進剤としては特に限定されないが、アンミビスナガ抽出物、サンショウ抽出物、ゲンチアナ抽出物、芥子抽出物、唐辛子抽出物、生姜抽出物、オタネニンジン抽出物、イチョウ抽出物、アルニカ抽出物、紅花抽出物、センブリ抽出物、メリロート抽出物、セイヨウトチノキ抽出物、カンフル及びその誘導体、ヒノキチオール及びその誘導体並びにそれらの塩、トコフェロール及びその誘導体、ニコチン酸及びその誘導体並びにそれらの塩、γ−オリザノール及びその誘導体、バニリルブチルエーテル、炭酸水素ナトリウムから選択される１種又は２種以上を用いることが好ましい。 Although it does not specifically limit as a blood circulation promoter mix | blended in the composition for slimmings of this invention, Anmibis Naga extract, a salamander extract, a gentian extract, a coconut extract, a chili extract, a ginger extract, a ginseng extract, a ginkgo biloba Extract, arnica extract, safflower extract, assembly extract, merirot extract, horse chestnut extract, camphor and its derivatives, hinokitiol and its derivatives and their salts, tocopherol and its derivatives, nicotinic acid and its derivatives and their It is preferable to use 1 type (s) or 2 or more types selected from the salt of these, (gamma)-oryzanol and its derivative (s), vanillyl butyl ether, and sodium hydrogencarbonate.
ここで、アンミビスナガ（Ａｍｍｉ ｖｉｓｎａｇａ）は、セリ科ドクゼリモドキ属に属する双子葉植物である。本発明においては、アンミビスナガの地上部及び地下部の全部位が使用可能で、その種子、果実部、花部、葉部、根部、茎部などの各部位を単独で或いは適宜混合して用いてもよい。尚、本発明においては、種子を用いることが好ましい。また、アンミビスナガから得られる成分、ビスナジンを用いることも可能である。 Here, Anmibisunaga (Ammi visnaga) is a dicotyledonous plant belonging to the Umbelliferae Cicuta virosa beetle genus. In the present invention, all parts of the above-ground part and underground part of Amibibis Naga can be used, and each part of the seed, fruit part, flower part, leaf part, root part, stem part, etc. may be used alone or in combination as appropriate. Also good. In the present invention, it is preferable to use seeds. It is also possible to use a component obtained from Ambivis Naga, bisnadin.
本発明の痩身用組成物において、血行促進剤の配合量は、痩身用組成物全量に対して、０．００１〜５質量％、より好ましくは、０．０１〜３質量％である。 In the slimming composition of the present invention, the blending amount of the blood circulation promoter is 0.001 to 5 mass%, more preferably 0.01 to 3 mass%, based on the total amount of the slimming composition.
本発明の痩身用組成物において配合するアミノ酸としては特に限定されないが、ロイシン、イソロイシン、バリン、トリプトファン、リシン、メチオニン、フェニルアラニン、スレオニン、バリン、ロイシン、イソロイシン、ヒスチジン、アルギニンから選択される１種又は２種以上を用いることが好ましい。本発明においては、これらのアミノ酸のうちロイシン、イソロイシン、バリンから選択される１種又は２種以上を用いることが、痩身効果の点から特に好ましい。 Although it does not specifically limit as an amino acid mix | blended in the composition for slimming of this invention, 1 type selected from leucine, isoleucine, valine, tryptophan, lysine, methionine, phenylalanine, threonine, valine, leucine, isoleucine, histidine, arginine or Two or more are preferably used. In this invention, it is especially preferable from the point of a slimming effect to use 1 type, or 2 or more types selected from leucine, isoleucine, and valine among these amino acids.
本発明の痩身用組成物は、血行促進剤とアミノ酸を併用することにより、痩身効果が相乗的に向上する。本発明の痩身用組成物において、血行促進剤とアミノ酸の配合比は特に限定されず、血行促進剤１質量部に対し、アミノ酸が０．０１〜１００質量部の範囲である。 The slimming composition of the present invention synergistically improves the slimming effect by using a blood circulation promoter and an amino acid in combination. In the composition for slimming of the present invention, the mixing ratio of the blood circulation promoter and the amino acid is not particularly limited, and the amino acid is in the range of 0.01 to 100 parts by mass with respect to 1 part by mass of the blood circulation promoter.
本発明の痩身用組成物は、痩身用外用剤のほか、痩身用経口剤としても利用することができる。 The slimming composition of the present invention can be used as a slimming oral preparation in addition to a slimming external preparation.
痩身用外用剤の剤型は任意であり、例えば、ローションなどの可溶化系、クリームや乳液などの乳化系、カラミンローション等の分散系として提供することができる。さらに、噴射剤と共に充填したエアゾール、軟膏剤、粉末、顆粒などの種々の剤型で提供することもできる。本発明の痩身用組成物を外用剤に配合する際の配合量は、外用剤の種類や使用目的等によって調整することができるが、効果や安定性などの点から、全量に対して０．０００１〜５０．０質量％が好ましく、より好ましくは、０．００１〜２５．０質量％である。 The dosage form of the slimming external preparation is arbitrary, and can be provided as, for example, a solubilizing system such as lotion, an emulsifying system such as cream or emulsion, or a dispersing system such as calamine lotion. Furthermore, it can also be provided in various dosage forms such as aerosols, ointments, powders and granules filled with a propellant. The blending amount of the slimming composition of the present invention when blended with the external preparation can be adjusted depending on the type of external preparation and the purpose of use. 0001-50.0 mass% is preferable, More preferably, it is 0.001-25.0 mass%.
なお、痩身用組成物を配合する外用剤には、痩身用組成物の他に、必要に応じて、通常医薬品、医薬部外品、皮膚化粧料、毛髪用化粧料及び洗浄料に配合される、油性成分、保湿剤、粉体、色素、乳化剤、可溶化剤、洗浄剤、紫外線吸収剤、増粘剤、薬剤、香料、樹脂、防菌防黴剤、アルコール類等を適宜配合することができる。 In addition to the slimming composition, the external preparation for blending the slimming composition is usually blended with pharmaceuticals, quasi-drugs, skin cosmetics, hair cosmetics and cleaning agents as necessary. Oily ingredients, moisturizers, powders, pigments, emulsifiers, solubilizers, detergents, UV absorbers, thickeners, drugs, fragrances, resins, antibacterial / antifungal agents, alcohols, etc. it can.
本発明の痩身用組成物は、医薬部外品、飲食物等の成分、食品添加物などとして使用し、痩身用経口剤することできる。当該使用により、本発明の痩身効果を有する当該痩身用組成物の日常的および継続的な摂取が可能となる。本発明の痩身用組成物が食品素材として使用される例としては、痩身効果または予防効果を有する機能性食品、健康食品、一般食品（ジュース、菓子、加工食品等）、栄養補助食品（栄養ドリンク等）が挙げられる。 The slimming composition of the present invention can be used as a slimming oral preparation by using it as a quasi-drug, a component of food or drink, a food additive, or the like. The use enables daily and continuous intake of the slimming composition having the slimming effect of the present invention. Examples of use of the slimming composition of the present invention as a food material include functional foods having a slimming effect or a preventive effect, health foods, general foods (juices, confectionery, processed foods, etc.), nutritional supplements (nutrient drinks) Etc.).
以下に本発明の痩身用組成物の処方例、使用試験についてさらに詳細に説明するが、本発明の技術的範囲はこれによってなんら限定されるものではない。 Hereinafter, formulation examples and use tests of the slimming composition of the present invention will be described in more detail. However, the technical scope of the present invention is not limited by this.
表１に示す処方で、本発明の痩身用組成物にかかる温感マッサージを調製し、使用試験を行った。使用試験は、肥満を気にする２０〜５０才の男女計１０名を一群として、実施例若しくは比較例をブラインドにて１日１回２週間使用させ、使用前後のウェストを測定した。結果を表１にまとめる。
判定基準
平均３．０ｃｍ以上減少：◎
平均１．０ｃｍ以上３．０ｃｍ未満減少：○
使用前後のサイズの変化が平均１．０ｃｍ未満：△
平均１．０ｃｍ以上増加：×
With the formulation shown in Table 1, a warm sensation massage according to the slimming composition of the present invention was prepared, and a use test was conducted. In the use test, a total of 10 males and females aged 20 to 50 who care about obesity were used as a group, and the examples or comparative examples were used blind once a day for 2 weeks, and the waist before and after use was measured. The results are summarized in Table 1.
Judgment standard average reduced by more than 3.0cm: ◎
Average decrease from 1.0 cm to less than 3.0 cm: ○
Average change in size before and after use is less than 1.0 cm: Δ
Average increase over 1.0 cm: ×
表１に示した通り、本発明の痩身用組成物は、血行促進剤若しくはアミノ酸を単独で配合した比較例とよりはるかに高い痩身効果を発揮していた。 As shown in Table 1, the slimming composition of the present invention exhibited a much higher slimming effect than the comparative example in which the blood circulation promoter or amino acid was blended alone.
［処方例２］ エアゾール型マッサージ料
(１)２−アルキル−Ｎ−カルボキシメチル ０．３７５(質量％)
−Ｎ−ヒドロキシエチルイミダゾリニウムベタイン
(２)ｌ−メンチルグリセリルエーテル ０．０２５
(３)アラントイン ０．００５
(４)エタノール ３．７５０
(５)クエン酸 ０．００５
(６)グリチルリチン酸ジカリウム ０．００５
(７)生姜抽出物 ０．００２
(８)Ｌ−アルギニン ０．００２
(９)精製水 ２０．８３１
(10)イソブタン(噴射剤) ７５．０００
製法：イソブタン以外の全成分を混合，均質化した後、イソブタンと共にエアゾール容器に充填する。
[Prescription Example 2] Aerosol-type massage fee
(1) 2-alkyl-N-carboxymethyl 0.375 (mass%)
-N-hydroxyethylimidazolinium betaine
(2) l-menthyl glyceryl ether 0.025
(3) Allantoin 0.005
(4) Ethanol 3.750
(5) Citric acid 0.005
(6) Dipotassium glycyrrhizinate 0.005
(7) Ginger extract 0.002
(8) L-arginine 0.002
(9) Purified water 20.831
(10) Isobutane (propellant) 75.000
Production method: All components other than isobutane are mixed and homogenized, and then filled into an aerosol container together with isobutane.
［処方例３］ ボディジェル
(１)１，３−ブチレングリコール ２．００(質量％)
(２)２−アミノ−２−メチル−１−プロパノール ０．３０
(３)ｌ−メンチルグリセリルエーテル ０．０１
(４)キサンタンガム ０．５０
(５)ポリエチレングリコール１５４０ １．００
(６)ポリオキシエチレン(５０ＥＯ)硬化ヒマシ油 ０．２０
(７)酢酸トコフェロール ０．０５
(８)サンショウ抽出物 ０．０５
(９)Ｌ−ロイシン ０．０５
(10)Ｌ−イソロイシン ０．０５
(11)Ｌ−バリン ０．１０
(12)エタノール ４０．００
(13)精製水 ５５．６９
製法：全成分を、混合均質化して、ボディジェルを調製した。
[Prescription Example 3] Body Gel
(1) 1,3-butylene glycol 2.00 (mass%)
(2) 2-Amino-2-methyl-1-propanol 0.30
(3) l-menthyl glyceryl ether 0.01
(4) Xanthan gum 0.50
(5) Polyethylene glycol 1540 1.00
(6) Polyoxyethylene (50EO) hydrogenated castor oil 0.20
(7) Tocopherol acetate 0.05
(8) Salamander extract 0.05
(9) L-leucine 0.05
(10) L-isoleucine 0.05
(11) L-valine 0.10
(12) Ethanol 40.00
(13) Purified water 55.69
Production method: All components were mixed and homogenized to prepare a body gel.
［処方例４］ 固形石鹸
(１)セッケン素地 ９６．０００(質量％)
(２)アルギン酸ナトリウム ０．００４
(３)エデト酸四ナトリウム四水塩 ０．２００
(４)クエン酸 ０．０２０
(５)乳酸 ０．０１０
(６)センブリ抽出物 ０．００５
(７)Ｌ−ロイシン ０．００５
(８)Ｌ−イソロイシン ０．００５
(９)Ｌ−バリン ０．００５
(10)ニガリ ０．００５
(11)精製水 ３．７４１
製法：全成分を、混合均質化後、プレス成形して固形石鹸を調製した。
[Formulation Example 4] Bar soap
(1) Soap base 96.000 (mass%)
(2) Sodium alginate 0.004
(3) Edetate tetrasodium tetrahydrate 0.200
(4) Citric acid 0.020
(5) Lactic acid 0.010
(6) Assembly extract 0.005
(7) L-leucine 0.005
(8) L-isoleucine 0.005
(9) L-valine 0.005
(10) Bittern 0.005
(11) Purified water 3.741
Production method: After all components were mixed and homogenized, solid soap was prepared by press molding.
［処方例５］ 入浴剤
(１)香料 ０．３００(質量％)
(２)Ｌ−ロイシン ０．０１０
(３)Ｌ−イソロイシン ０．００５
(４)Ｌ−バリン ０．００５
(５)ヒノキチオール ０．００５
(６)炭酸水素ナトリウム ４９．０００
(７)硫酸ナトリウム ５０．６７５
製法：全成分を、均一に混合する。
[Formulation Example 5] Bath salt
(1) Fragrance 0.300 (mass%)
(2) L-leucine 0.010
(3) L-isoleucine 0.005
(4) L-valine 0.005
(5) Hinokitiol 0.005
(6) Sodium bicarbonate 49.000
(7) Sodium sulfate 50.675
Manufacturing method: All components are mixed uniformly.
［処方例６］ 飲料
(１)メリロート抽出物 ０．００５(質量％)
(２)オタネニンジン抽出物 ０．００５
(３)Ｌ−ロイシン ０．００５
(４)Ｌ−イソロイシン ０．００５
(５)Ｌ−バリン ０．００５
(６)エリスリトール １．０００
(７)クエン酸 ０．１００
(８)ステビア ０．０５０
(９)精製水 ９８．８２５
製法：全成分を、均一に混合する。
[Prescription Example 6] Beverage
(1) Merirot extract 0.005 (mass%)
(2) Panax ginseng extract 0.005
(3) L-leucine 0.005
(4) L-isoleucine 0.005
(5) L-valine 0.005
(6) Erythritol 1.000
(7) Citric acid 0.100
(8) Stevia 0.050
(9) Purified water 98.825
Manufacturing method: All components are mixed uniformly.
［処方例７］ 錠剤
(１)イチョウ抽出物 ０．０１(質量部)
(２)Ｌ−ロイシン ０．０１
(３)Ｌ−イソロイシン ０．０１
(４)Ｌ−バリン ０．０１
(５)ステアリン酸マグネシウム ０．０１
(６)乳糖 ０．２５
製法：全成分を混合し、打錠機にて打錠し、直径１０mm、質量３００mgの錠剤とした。
[Prescription Example 7] Tablet
(1) Ginkgo biloba extract 0.01 (parts by mass)
(2) L-leucine 0.01
(3) L-isoleucine 0.01
(4) L-valine 0.01
(5) Magnesium stearate 0.01
(6) Lactose 0.25
Production method: All components were mixed and tableted with a tableting machine to obtain tablets with a diameter of 10 mm and a mass of 300 mg.
［処方例８］ 散剤
(１)紅花抽出物 ０．００５(質量％)
(２)Ｌ−ロイシン ０．００５
(３)Ｌ−イソロイシン ０．００５
(４)Ｌ−バリン ０．００５
(５)ニガリ ０．０１０
(６)還元乳糖 ３．０００
(７)大豆オリゴ糖 ３．０００
(８)エリスリトール ３．０００
(９)デキストリン ８１．０００
(10)精製水 ９．９７０
製法：全成分を均一に混合攪拌し、スプレードライを行い散剤とする。
[Prescription Example 8] Powder
(1) Safflower extract 0.005 (mass%)
(2) L-leucine 0.005
(3) L-isoleucine 0.005
(4) L-valine 0.005
(5) Bittern 0.010
(6) Reduced lactose 3000
(7) Soybean oligosaccharide 3000
(8) Erythritol 3000
(9) Dextrin 81.000
(10) Purified water 9.970
Manufacturing method: All components are mixed and stirred uniformly, and spray dried to form a powder.
［処方例９］ マッサージジェル
(１)精製水 ７９．２１(質量％)
(２)アクリル酸・メタクリル酸アルキル共重合体 ０．５０
(３)１，３−ブチレングリコール ６．００
(４)濃グリセリン ３．００
(５)水素添加大豆リン脂質 ０．２５
(６)スクワラン １．００
(７)デカメチルシクロペンタシロキサン １．５０
(８)パラオキシ安息香酸エステル ０．１０
(９)パラメトキシケイ皮酸２−エチルヘキシル ４．００
(10)モノイソステアリン酸ポリグリセリル ０．２０
(11)水酸化カリウム（１０質量％水溶液） ２．００
(12)精製水 ２．００
(13)アンミビスナガ抽出物 ０．１０
(14)トウガラシチンキ ０．０３
(15)Ｌ−バリン ０．０２
(16)Ｌ−イソロイシン ０．０２
(17)Ｌ−ロイシン ０．０４
(18)γ−グルタミン酸ポリペプチド ０．０２
(19)ｌ−メンチルグリセリルエーテル ０．０１
製法：(１)に(２)〜(５)を溶解して水相とする。(６)〜(10)を均一溶解し油相とする。水相に油相を添加して乳化後、(11)を添加して増粘させるたものに、(12)〜(19)の混合物を添加する。
[Prescription Example 9] Massage Gel
(1) Purified water 79.21 (mass%)
(2) Acrylic acid / alkyl methacrylate copolymer 0.50
(3) 1,3-butylene glycol 6.00
(4) Concentrated glycerin 3.00
(5) Hydrogenated soybean phospholipid 0.25
(6) Squalane 1.00
(7) Decamethylcyclopentasiloxane 1.50
(8) Paraoxybenzoic acid ester 0.10
(9) 2-Methylhexyl paramethoxycinnamate 4.00
(10) Polyglyceryl monoisostearate 0.20
(11) Potassium hydroxide (10 mass% aqueous solution) 2.00
(12) Purified water 2.00
(13) Amibibis Naga extract 0.10
(14) Pepper tincture 0.03
(15) L-valine 0.02
(16) L-isoleucine 0.02
(17) L-leucine 0.04
(18) γ-glutamic acid polypeptide 0.02
(19) l-menthyl glyceryl ether 0.01
Production method: (2) to (5) are dissolved in (1) to form an aqueous phase. (6) to (10) are uniformly dissolved to form an oil phase. After emulsification by adding the oil phase to the aqueous phase, the mixture of (12) to (19) is added to the mixture obtained by adding (11) to increase the viscosity.
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| JP4469406B1 (en) * | 2009-06-30 | 2010-05-26 | 株式会社ファンケル | Blood cholesterol lowering agent |
| US8372447B2 (en) * | 2010-08-03 | 2013-02-12 | Northern Innovations And Formulations Corp. | Compositions and methods for promoting weight loss and increasing energy |
| JP5966231B1 (en) * | 2015-12-14 | 2016-08-10 | 有限会社アント | Amino acid-containing facial skin preparation |
| CN106265408A (en) * | 2015-06-05 | 2017-01-04 | 颜笑天 | A kind of tibet red salt showering agent |
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