JP2007533693A - Ｈｃｖ阻害剤としてのアシルジヒドロピロール誘導体 - Google Patents
Ｈｃｖ阻害剤としてのアシルジヒドロピロール誘導体 Download PDFInfo
- Publication number
- JP2007533693A JP2007533693A JP2007508842A JP2007508842A JP2007533693A JP 2007533693 A JP2007533693 A JP 2007533693A JP 2007508842 A JP2007508842 A JP 2007508842A JP 2007508842 A JP2007508842 A JP 2007508842A JP 2007533693 A JP2007533693 A JP 2007533693A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- heteroaryl
- formula
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC(CC(C1N)N)(*1C(O)=O)C(*)=O Chemical compound CC(CC(C1N)N)(*1C(O)=O)C(*)=O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0408995.9A GB0408995D0 (en) | 2004-04-22 | 2004-04-22 | Compounds |
| PCT/EP2005/004270 WO2005103045A1 (fr) | 2004-04-22 | 2005-04-20 | Derives acyl-dihydro-pyrrole utilises en tant qu'inhibiteurs du vhc |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2007533693A true JP2007533693A (ja) | 2007-11-22 |
Family
ID=32344223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007508842A Pending JP2007533693A (ja) | 2004-04-22 | 2005-04-20 | Ｈｃｖ阻害剤としてのアシルジヒドロピロール誘導体 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1740582A1 (fr) |
| JP (1) | JP2007533693A (fr) |
| GB (1) | GB0408995D0 (fr) |
| WO (1) | WO2005103045A1 (fr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| AU2008248116A1 (en) | 2007-05-04 | 2008-11-13 | Vertex Pharmaceuticals Incorporated | Combination therapy for the treatment of HCV infection |
| US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
| MX2011006891A (es) | 2008-12-23 | 2011-10-06 | Pharmasset Inc | Fosforamidatos de nucleosidos. |
| EP2671888A1 (fr) | 2008-12-23 | 2013-12-11 | Gilead Pharmasset LLC | Analogues de nucléoside phosphates 3',5'-cycliques |
| EA201100851A1 (ru) | 2008-12-23 | 2012-04-30 | Фармассет, Инк. | Аналоги нуклеозидов |
| TWI583692B (zh) | 2009-05-20 | 2017-05-21 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
| US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| WO2011123672A1 (fr) | 2010-03-31 | 2011-10-06 | Pharmasset, Inc. | Phosphoramidate de nucléoside de type purine |
| PL3290428T3 (pl) | 2010-03-31 | 2022-02-07 | Gilead Pharmasset Llc | Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu |
| EP2552931B1 (fr) | 2010-03-31 | 2014-07-23 | Gilead Pharmasset LLC | Synthèse stéréosélective d'agents actifs contenant du phosphore |
| US8841275B2 (en) | 2010-11-30 | 2014-09-23 | Gilead Pharmasset Llc | 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections |
| US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
| PT3038601T (pt) | 2013-08-27 | 2020-06-30 | Gilead Pharmasset Llc | Formulação combinada de dois compostos antivirais |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050009873A1 (en) * | 2001-11-02 | 2005-01-13 | Gianpaolo Bravi | Acyl dihydro pyrrole derivatives as hcv inhibitors |
| ATE418554T1 (de) * | 2002-10-24 | 2009-01-15 | Glaxo Group Ltd | 1-acyl-pyrrolidin-derivate für die behandlung von viralen infektionen |
-
2004
- 2004-04-22 GB GBGB0408995.9A patent/GB0408995D0/en not_active Ceased
-
2005
- 2005-04-20 JP JP2007508842A patent/JP2007533693A/ja active Pending
- 2005-04-20 EP EP05734941A patent/EP1740582A1/fr not_active Withdrawn
- 2005-04-20 WO PCT/EP2005/004270 patent/WO2005103045A1/fr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1740582A1 (fr) | 2007-01-10 |
| WO2005103045A1 (fr) | 2005-11-03 |
| GB0408995D0 (en) | 2004-05-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007533693A (ja) | Ｈｃｖ阻害剤としてのアシルジヒドロピロール誘導体 | |
| US7304087B2 (en) | 1-acyl-pyrrolidine derivatives for the treatment of viral infections | |
| JP2008517968A (ja) | Ｃ型肝炎ウイルス阻害薬としての４−メトキシメチル−ピロリジン−２−カルボン酸化合物およびその誘導体 | |
| EP2222672B1 (fr) | Dérivés d'indole à substitution par aminosulfonyle en position 3 et leurs procédés d'utilisation | |
| JP2005515172A (ja) | Ｈｃｖ阻害剤としての４−（６−員）−ヘテロアリールアシルピロリジン誘導体 | |
| US20050043545A1 (en) | 4-(5-Membered)-heteroaryl acyl pyrrolidine derivatives as hcv inhibitors | |
| JP2005511572A (ja) | Ｈｃｖ阻害剤としてのアシルジヒドロピロール誘導体 | |
| WO2007039145A1 (fr) | Composes de c (2) -heteroarylmethyl-c (4) -pyrazinyl-2-yl acyl pyrrolidine et leur utilisation pour traiter des infections virales, en particulier le virus de l'hepatite c | |
| WO2007039142A1 (fr) | Composes de heteroarylmethyl-c (4) -methoxymethyl acyl pyrrolidine et leur utilisation dans le traitement d'infections virales, en particulier du virus de l'hepatite c | |
| WO2004096210A1 (fr) | Derives acyles d'indolines et de tetrahydroquinoleines constituant des inhibiteurs du vhc | |
| US20090227600A1 (en) | 4-(pyrazine-2-yl) -pyrrolidine -2-carboxylic acid compounds and derivatives thereof as hepatitis c virus inhibitors | |
| US20050176801A1 (en) | Acyl bicyclic derivatives of pyrrol | |
| WO2004009543A2 (fr) | Composes | |
| WO2007039143A1 (fr) | Composes de c (2) -heteroarylmethyl-c (4) -pyrazin-2-yl acyl pyrrolidine et leur utilisation pour traiter des infections virales, en particulier le vhc | |
| WO2004076415A1 (fr) | Derives d'acide 1- (hetero)aroyl-pyrrolidine-2-carboxylique utiles comme agents anti-viraux | |
| WO2007039144A1 (fr) | Derives de pyrrolidine utilises pour traiter des infections virales | |
| WO2004060889A1 (fr) | Acides 2-pyrrolidine-carboxyliques a substitution 5-thiazole | |
| ZA200502945B (en) | 1-Acyl-pyrrolidine derivatives for the treatment of viral infections. |