JP2007526802A - 椎間板プロテーゼ - Google Patents
椎間板プロテーゼ Download PDFInfo
- Publication number
- JP2007526802A JP2007526802A JP2006551952A JP2006551952A JP2007526802A JP 2007526802 A JP2007526802 A JP 2007526802A JP 2006551952 A JP2006551952 A JP 2006551952A JP 2006551952 A JP2006551952 A JP 2006551952A JP 2007526802 A JP2007526802 A JP 2007526802A
- Authority
- JP
- Japan
- Prior art keywords
- plate
- core
- prosthesis
- intervertebral disc
- disc prosthesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000001681 protective effect Effects 0.000 claims description 45
- 238000003780 insertion Methods 0.000 claims description 13
- 230000037431 insertion Effects 0.000 claims description 13
- 230000000295 complement effect Effects 0.000 claims description 8
- 239000002184 metal Substances 0.000 claims description 8
- 210000000988 bone and bone Anatomy 0.000 claims description 5
- 238000006073 displacement reaction Methods 0.000 claims description 4
- 210000001519 tissue Anatomy 0.000 claims description 4
- 239000004698 Polyethylene Substances 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 210000003722 extracellular fluid Anatomy 0.000 claims description 3
- 238000005461 lubrication Methods 0.000 claims description 3
- -1 polyethylene Polymers 0.000 claims description 3
- 229920000573 polyethylene Polymers 0.000 claims description 3
- 230000000149 penetrating effect Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 2
- 239000000463 material Substances 0.000 description 5
- 230000001154 acute effect Effects 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 239000002923 metal particle Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30841—Sharp anchoring protrusions for impaction into the bone, e.g. sharp pins, spikes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30904—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves serrated profile, i.e. saw-toothed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2002/30934—Special articulating surfaces
- A61F2002/30937—Special articulating surfaces with cut-outs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/442—Intervertebral or spinal discs, e.g. resilient
- A61F2/4425—Intervertebral or spinal discs, e.g. resilient made of articulated components
- A61F2002/443—Intervertebral or spinal discs, e.g. resilient made of articulated components having two transversal endplates and at least one intermediate component
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4603—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
- A61F2002/4622—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof having the shape of a forceps or a clamp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/0033—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements made by longitudinally pushing a protrusion into a complementary-shaped recess, e.g. held by friction fit
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
Claims (32)
- 第1のプレート(1)、第2のプレート(2)、およびプレート(1、2)の少なくとも一方に対して可動なコア(3)を含む少なくとも3つの部分を備え、コア(3)が、第1のプレート(1)の相補的に湾曲した表面の少なくとも一部分と接触する湾曲した表面、および第2のプレート(2)の実質的に平坦な表面の少なくとも一部分と接触する実質的に平坦な表面を有しており、第2のプレート(2)およびコア(3)の周辺近くに存在する協働手段(22、31)が、実質的に平坦な表面に対して実質的に平行な軸に沿った第2のプレートに対するコアの平行移動動作を、過度の摩擦なしに制限または阻止することができ、かつ実質的に平坦な表面に対して実質的に垂直な軸のまわりの、第2のプレートに対するコアの回転動作を制限または阻止することができる椎間板プロテーゼであって、コア(3)の少なくとも実質的に平坦な表面が、接触する第2のプレート(2)の実質的に平坦な表面に対するコア(3)の摺動を容易にする少なくとも1つのダミー穴(41)を有することを特徴とする椎間板プロテーゼ。
- 少なくとも実質的に平坦な表面が、コア(3)の下部表面、および下部プレートとして知られる第2のプレート(2)の上部表面であることを特徴とする請求項1に記載の椎間板プロテーゼ。
- コア(3)の少なくとも実質的に平坦な表面が、第2のプレート(2)の実質的に平坦な表面と接触しかつコア(3)の実質的に平坦な部分と接触するその表面に少なくとも1つの穴(41)を有する保護シェル(4)中に収納されることを特徴とする請求項1および2のいずれか一項に記載の椎間板プロテーゼ。
- コアの保護シェル(4)が、第2のプレート(2)の協働手段(22)と保護シェル(4)との接触を回避するために、コアの協働手段(31)を覆わないことを特徴とする請求項3に記載の椎間板プロテーゼ。
- 第2のプレート(2)の実質的に平坦な表面とコア(3)または保護シェル(4)の実質的に平坦な表面との接触する面積と、第1のプレート(1)の湾曲した表面とコア(3)の湾曲した表面との接触する面積とが、コア(3)の両側面で実質的に等しいことを特徴とする請求項1から4のいずれか一項に記載の椎間板プロテーゼ。
- コア(3)の、またはコア(3)の保護シェル(4)の少なくとも実質的に平坦な表面上に存在する穴(41)の縁部(411)によって形成される角度が、第2のプレート(2)の実質的に平坦な表面上でのコア(3)またはシェル(4)の摺動を改善するように、緩和されることを特徴とする請求項1から5のいずれか一項に記載の椎間板プロテーゼ。
- コア(3)の、またはコアの保護シェル(4)の実質的に平坦な表面上に存在する穴(41)が、プロテーゼが患者に配置されたとき、周囲組織からの間質性液が、コア(3)の第2のプレート(2)の実質的に平坦な表面上での摺動を改善する潤滑の役割を果たすことが可能なチャネルを形成する溝部(410)により、実質的に平坦な表面の周辺部まで延長されることを特徴とする請求項1から6のいずれか一項に記載の椎間板プロテーゼ。
- コア(3)の、またはコアの保護シェル(4)の実質的に平坦な表面の周辺部まで穴(41)を延長する溝部(410)の縁部(411)によって形成される角度が、第2のプレート(2)の実質的に平坦な表面上でのコア(3)またはシェル(4)の摺動を改善するように、緩和されることを特徴とする請求項7に記載の椎間板プロテーゼ。
- コア(3)がポリエチレンから作られることを特徴とする請求項1から8のいずれか一項に記載の椎間板プロテーゼ。
- コア(3)の保護シェル(4)が金属から作られることを特徴とする請求項1から9のいずれか一項に記載の椎間板プロテーゼ。
- 第1(1)のプレートおよび第2(2)のプレートが金属から作られることを特徴とする請求項1から10のいずれか一項に記載の椎間板プロテーゼ。
- 協働手段が、コア(3)のメス手段(31)と協働する、第2のプレート(2)のオス手段(22)にあることを特徴とする請求項1から11のいずれか一項に記載の椎間板プロテーゼ。
- コア(3)が、第1のプレート(1)および/または第2(2)のプレートに対して移動可能であり、また第1(1)のプレートと第2(2)のプレートの間での可変の角度がコア(3)の位置に依存しており、いずれの方向であっても、少なくとも第1のプレート(1)の傾斜が、プレート(1、2)相互間でコア(3)の変位を引き起こし、かつ患者の動きの自由度を提供し、同時にプロテーゼの位置決めの欠点をなくす助けとなることを特徴とする請求項1から12のいずれか一項に記載の椎間板プロテーゼ。
- コア(3)の上部表面および下部表面に相当する平面手段が角度を形成することにより、または第1のプレート(1)および/または第2のプレート(2)の上部表面および下部表面に相当する平面手段が角度を形成することにより、または少なくとも第1のプレート(1)の傾斜を与える位置の周囲にコア(3)の動作を制限することにより、上部プレート(1、2)の上部表面と、下部プレート(2、1)の下部表面の間に角度を与えられることを特徴とする請求項1から13のいずれか一項に記載の椎間板プロテーゼ。
- 同じプレート(1、2)を、様々な厚さのコア(3)と組み立て可能であることを特徴とする請求項1から14のいずれか一項に記載の椎間板プロテーゼ。
- 第1のプレート(1)の表面の少なくとも一部分が、凹形状をしており、またそれと接触するコア(3)の表面と相補的であることを特徴とする請求項1から15のいずれか一項に記載の椎間板プロテーゼ。
- 各オス手段の寸法が、コア(3)と第2のプレート(2)の間でわずかなクリアランスを許容するように、各メス手段の寸法よりわずかに小さいことを特徴とする請求項1から16のいずれか一項に記載の椎間板プロテーゼ。
- 各オス手段の寸法が、コア(3)と第2のプレート(2)の間の任意のクリアランスを阻止するように、各メス手段の寸法と実質的に同じであることを特徴とする請求項1から17のいずれか一項に記載の椎間板プロテーゼ。
- 第2のプレート(2)のオス手段(22)が、プロテーゼの2つの縁部上に互いに反対側に存在する2つの接触プレートであり、またコア(3)のメス手段(31)が2つの凹部であることを特徴とする請求項1から18のいずれか一項に記載の椎間板プロテーゼ。
- 第2のプレート(2)のオス手段(22)が、プロテーゼの2つの縁部の近傍に互いに反対側に存在する2つの壁であり、またコア(3)のメス手段(31)が凹部であることを特徴とする請求項1から18のいずれか一項に記載の椎間板プロテーゼ。
- 下部プレート(2)のオス手段(22)が、プロテーゼの内部方向に湾曲し、かつプロテーゼの2つの縁部上に互いに反対側に存在する2つの尖端部であり、またコア(3)のメス手段(31)が2つの凹部であることを特徴とする請求項1から18のいずれか一項に記載の椎間板プロテーゼ。
- 尖端部の少なくとも1つが、穴を備えるピンにより置き換えられ、またその上に、穴を貫通するダウエルによりプレートが固定されることを特徴とする請求項21に記載の椎間板プロテーゼ。
- 下部プレート(2、1)の下部表面および上部プレート(1、2)の上部表面が、椎骨と接触して、プレート(1、2)の表面の多孔質の生体適合性のあるコーティングにより可能となる骨組織への接合前のプロテーゼの摺動を阻止するように方向付けられた、プロテーゼの少なくとも2つの縁部の近傍に存在する歯、またはノッチ(21、11)を備えることを特徴とする請求項1から22のいずれか一項に記載の椎間板プロテーゼ。
- 少なくとも第2のプレート(2)が、椎骨にプロテーゼの固定手段を受け入れるように設けられた、その前側の近傍にある1つまたは複数の開口部を備えることを特徴とする請求項1から23のいずれか一項に記載の椎間板プロテーゼ。
- 第2のプレート(2)の開口部が円形であり、また固定手段がスタッドの形状を有することを特徴とする請求項24に記載の椎間板プロテーゼ。
- 固定手段の頭部が、第2のプレート(2)の開口部よりも大きい寸法を有しており、固定手段が椎骨中に固定され、第2のプレート(2)が固定手段の頭部と前記椎骨の間で挟み込まれることを特徴とする請求項24および25のいずれか一項に記載の椎間板プロテーゼ。
- 上部プレートが、椎骨の形に適合するように、その上部表面の少なくとも一部分で***していることを特徴とする請求項1から26のいずれか一項に記載の椎間板プロテーゼ。
- 第1のプレート(1)、第2のプレート(2)、および少なくとも第2のプレート(2)に対して可動なコア(3)により構成される椎間板プロテーゼの、2つの椎骨の間への挿入デバイスであって、プロテーゼの前縁部の形に適合するように提供された形状を前部表面(71)が有し、またプロテーゼの把持手段(72)を少なくとも2つの縁部が備えるクリップ(7)を含むことを特徴とする挿入デバイス。
- クリップ(7)の少なくとも2つの縁部上に存在する把持手段(72)が、クリップの横方向縁部上にマウントされた、またプロテーゼの上部(1)プレートおよび下部(2)プレートの横方向縁部を挟むことによってプロテーゼを保持する、2つの可撓性のあるブレードであることを特徴とする請求項28に記載のデバイス。
- クリップ(7)の前部表面(71)が、一方で、プロテーゼの各プレートの前縁部と接触するように、その高さがプロテーゼの高さに少なくとも実質的に等しいことにより、また、他方では、プレートの前縁部に対してわずかに引っ込んでいる、コア(3)の前縁部と同様に接触するためのクリップの前部表面の少なくとも中央部分にある少なくとも1つの溝部(711)により、プロテーゼの前縁部の形に適合するように提供される形状を有することを特徴とする請求項28および29のいずれか一項に記載のデバイス。
- クリップの後部表面がガイド(5)として知られるロッド(51)の第1の端部によって押されることができ、ロッドの他方の端部にプッシャ(52)と、ガイド(5)に沿った可変位置における制限装置(53)とを備え、制限装置はプロテーゼおよびクリップ(7)を受け入れるための寸法に作られたスペースが中に構成された頭部(62)を備えるチャージャ(6)の本体(61)の内側をガイドが摺動する長さを制限するためのものであり、クリップ(7)で保持されたプロテーゼが、チャージャ(6)の頭部(62)から押し出され、かつ制限装置(53)がチャージャ(6)の本体(61)に接触したとき、プロテーゼを間に植え込む必要のある2つの椎骨の垂直軸に対してセンタリングされるように、ガイド(5)上の制限装置(53)の位置が調整可能であることを特徴とする請求項28から30のいずれか一項に記載のデバイス。
- クリップ(7)の少なくとも2つの縁部の上に存在するプロテーゼの把持手段(72)の前端部がその後端部よりも大きく、その後端部におけるクリップ(7)の幅が、チャージャ(6)の頭部(62)中のスペースの幅に実質的に等しくなっており、したがって、プロテーゼおよびクリップ(7)が、チャージャ(6)の頭部(62)中にある場合、プロテーゼはクリップ(7)の把持手段(72)によりしっかりと保持され、次いで、クリップの把持手段は、プロテーゼと、チャージャの頭部(62)中に配置されたスペースの内壁との間で圧縮され、またプロテーゼはチャージャの頭部(62)から排出された場合、そこから解放され得るように、少し緩くクリップ(7)に保持されることを特徴とする請求項28から31のいずれか一項に記載のデバイス。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0401024A FR2865629B1 (fr) | 2004-02-04 | 2004-02-04 | Prothese de disque intervertebral |
FR04/01024 | 2004-02-04 | ||
PCT/IB2005/000280 WO2005074839A1 (en) | 2004-02-04 | 2005-02-04 | Intervertebral disc prosthesis |
Publications (2)
Publication Number | Publication Date |
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JP2007526802A true JP2007526802A (ja) | 2007-09-20 |
JP4996927B2 JP4996927B2 (ja) | 2012-08-08 |
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JP2006551952A Expired - Fee Related JP4996927B2 (ja) | 2004-02-04 | 2005-02-04 | 椎間板プロテーゼ |
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US (5) | US9655739B2 (ja) |
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JP (1) | JP4996927B2 (ja) |
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ZA200606484B (en) | 2008-01-08 |
PT2113227E (pt) | 2015-10-16 |
PT1711133E (pt) | 2011-06-01 |
PL2113227T3 (pl) | 2015-12-31 |
ES2547532T3 (es) | 2015-10-07 |
US20150032209A1 (en) | 2015-01-29 |
US20220241086A1 (en) | 2022-08-04 |
JP4996927B2 (ja) | 2012-08-08 |
IL176696A (en) | 2010-12-30 |
CN101961270A (zh) | 2011-02-02 |
RU2354334C2 (ru) | 2009-05-10 |
US20220241087A1 (en) | 2022-08-04 |
EP2113227A1 (en) | 2009-11-04 |
US20170258601A1 (en) | 2017-09-14 |
US11957598B2 (en) | 2024-04-16 |
DK2113227T3 (en) | 2015-11-02 |
EP2113227B1 (en) | 2015-07-29 |
KR101146215B1 (ko) | 2012-05-11 |
ES2363154T3 (es) | 2011-07-22 |
US20200205995A1 (en) | 2020-07-02 |
CN101961270B (zh) | 2016-08-10 |
RU2006131585A (ru) | 2008-03-10 |
ATE507803T1 (de) | 2011-05-15 |
BRPI0507468A (pt) | 2007-07-10 |
IL176696A0 (en) | 2006-10-31 |
DE602005027806D1 (de) | 2011-06-16 |
US10603185B2 (en) | 2020-03-31 |
KR20070058372A (ko) | 2007-06-08 |
US9655739B2 (en) | 2017-05-23 |
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