JP2007506522A5 - - Google Patents
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- JP2007506522A5 JP2007506522A5 JP2006528188A JP2006528188A JP2007506522A5 JP 2007506522 A5 JP2007506522 A5 JP 2007506522A5 JP 2006528188 A JP2006528188 A JP 2006528188A JP 2006528188 A JP2006528188 A JP 2006528188A JP 2007506522 A5 JP2007506522 A5 JP 2007506522A5
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- JP
- Japan
- Prior art keywords
- absorption spectrum
- spectrum
- reference blood
- light absorption
- reduced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000862 absorption spectrum Methods 0.000 claims 62
- 210000004369 Blood Anatomy 0.000 claims 40
- 239000008280 blood Substances 0.000 claims 40
- 230000031700 light absorption Effects 0.000 claims 31
- 238000001228 spectrum Methods 0.000 claims 18
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 15
- 229910052760 oxygen Inorganic materials 0.000 claims 15
- 239000001301 oxygen Substances 0.000 claims 15
- 230000000875 corresponding Effects 0.000 claims 6
- 238000006213 oxygenation reaction Methods 0.000 claims 5
- 238000010606 normalization Methods 0.000 claims 4
- 238000010192 crystallographic characterization Methods 0.000 claims 3
- 238000005259 measurement Methods 0.000 claims 3
- 238000010521 absorption reaction Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000003287 optical Effects 0.000 claims 1
Claims (26)
酸素付加の2つの異なるレベルに対応する少なくとも2つの参照血液吸収スペクトル(Amin(λ),Amax(λ))を、ある波長範囲にわたって集めるための手段;
被験体の血液に光を向けるための手段;
該血液から低減した光吸収スペクトルを感知するための手段;および
酸素飽和度の値(SO2,SaO2)を、該参照血液吸収スペクトルに対する該低減した光吸収スペクトルの関数として計算するための手段
によって特徴付けられる、システム。 A system for determining blood oxygen saturation, the following:
Means for collecting at least two reference blood absorption spectra (A min (λ), A max (λ)) corresponding to two different levels of oxygenation over a range of wavelengths;
Means for directing light on the blood of the subject;
Means for sensing light absorption spectrum reduced from blood; and oxygen saturation values (SO 2, S a O 2 ), to calculate as a function of the light absorption spectrum said reduced relative to the reference blood absorption spectrum A system characterized by means of:
最小血液酸素付加値および最大血液酸素付加値に対応する、少なくとも1つの最小参照血液吸収スペクトル(Amin(λ))および少なくとも1つの最大参照血液吸収スペクトル(Amax(λ))、ならびに少なくとも1つの中間参照血液吸収スペクトル(Ainter(X))を集めるための手段
該参照血液吸収スペクトルの少なくとも2つに対する前記低減した光吸収スペクトルの関数として、酸素飽和度の値を計算するための手段
によってさらに特徴付けられる、システム。 6. The system according to claim 5, wherein:
At least one minimum reference blood absorption spectrum (A min (λ)) and at least one maximum reference blood absorption spectrum (A max (λ)), corresponding to the minimum and maximum blood oxygenation values, and at least one one as a function of the light absorption spectrum the reduction for at least two means the reference blood absorption spectra for collecting intermediate reference blood absorption spectrum (a inter (X)), means for calculating the value of oxygen saturation < further characterized by the system .
前記2つの参照血液吸収スペクトルを決定するための手段であって、該2つの参照血液吸収スペクトルは、前記低減した光吸収スペクトルに最も近接しているが、それぞれ該低減した光吸収スペクトルよりも大きいスペクトル、および該低減した光吸収スペクトルよりも小さいスペクトルである、手段;ならびに
該最も近接している参照血液吸収スペクトルに関する該低減した光吸収スペクトルの一次補間によって、前記酸素飽和度の値を計算するための手段によってさらに特徴付けられる、システム。 The system according to any one of claims 1 to 7, wherein:
Means for determining the two reference blood absorption spectra, the two reference blood absorption spectra being closest to the reduced light absorption spectrum, each being greater than the reduced light absorption spectrum Means for calculating said oxygen saturation value by linear interpolation of said reduced light absorption spectrum with respect to said nearest reference blood absorption spectrum; and means which is a spectrum smaller than said reduced light absorption spectrum A system further characterized by means for:
によってさらに特徴付けられる、システム。 A system according to claim 1, means for taking white balance of the light absorption spectrum the reduction, and then the the white balance when calculating the value of the oxygen saturation further characterized, the system by means <br/> for using the light absorption spectrum reduced that is.
白色LEDから血液中に向けて光を発生するための手段;
白色LEDのスペクトルを予め決定するための手段;
該白色LEDスペクトルの表示を保存するための手段;および
該白色LEDのスペクトルの関数として、前記低減した光吸収スペクトルを調整するための手段
によってさらに特徴付けられる、システム。 The system according to any one of claims 1 to 9,
Means for generating light from the white LED into the blood;
Means for predetermining the spectrum of the white LED;
Means for storing a representation of the white LED spectrum; and as a function of the spectrum of the white LED, further characterized by means <br/> for adjusting the light absorption spectrum the reduced system.
によってさらに特徴付けられる、システム。 The system of claim 11, wherein the saving the display of the white LED spectrum permanently, thereby does not require further characterization of the light source, further characterized by means <br/>, system.
少なくとも1つのプロセッサ(340);
保存デバイス(330)であって、酸素付加の2つの異なるレベルに対応する、ある波長範囲にわたる少なくとも2つの参照血液吸収スペクトル(Amin(λ),Amax(λ))を、数値的に表現するパラメータを保存する、保存デバイス;
光源(301)であって、少なくとも該波長範囲にわたる光のスペクトルを発生する、光源;
光伝達配置(100,111;200,211)であって、該発生された光を該光源から被験体の血液中に向ける、光伝達配置;
光検出配置(112,212,302)であって、該血液からの低減した光吸収スペクトルを感知する、光検出配置;
調整回路(304)であって、該検出された低減した光を、数値的に表現された、測定された低減した吸収スペクトルへと変換する、調整回路;
計算ソフトウェアモジュール(310)であって、該参照血液吸収スペクトルに対する該低減した光吸収スペクトルの関数として酸素飽和度の値(SO2,SaO2)を計算するための、プロセッサで実行可能なコードを含む、計算ソフトウェアモジュール
によって特徴付けられる、システム。 A system for determining blood oxygen saturation, the following:
At least one processor (340);
A storage device (330), which numerically represents at least two reference blood absorption spectra (A min (λ), A max (λ)) over a range of wavelengths corresponding to two different levels of oxygenation Save parameters to save, save device;
A light source (301) for generating a spectrum of light over at least the wavelength range;
A light-transmitting arrangement (100, 111; 200, 211), wherein the generated light is directed from the light source into the blood of the subject;
A light detection arrangement (112, 212, 302) for sensing a reduced light absorption spectrum from the blood;
An adjustment circuit (304) for converting the detected reduced light into a numerically expressed measured reduced absorption spectrum;
A calculation software module (310) executable on a processor for calculating oxygen saturation values (SO 2 , S a O 2 ) as a function of the reduced light absorption spectrum relative to the reference blood absorption spectrum A system characterized by a computational software module containing code.
前記保存デバイス(330)が、最小血液酸素付加値および最大血液酸素付加値に対応する、少なくとも1つの最小参照血液吸収スペクトル(Amin(λ))および少なくとも1つの最大参照血液吸収スペクトル(Amax(λ))、ならびに少なくとも1つの中間参照血液吸収スペクトル(Ainter(λ))を数値的に表現するパラメータを含むこと;
前記計算ソフトウェアモジュール(310)が、該参照血液吸収スペクトルの少なくとも2つに対する前記低減した光吸収スペクトルの関数として、酸素飽和度の値を計算するための、プロセッサで実行可能なコードを含むこと
によって特徴付けられる、システム。 The system according to any one of claims 13 to 18, wherein:
The storage device (330) has at least one minimum reference blood absorption spectrum (A min (λ)) and at least one maximum reference blood absorption spectrum (A max ) corresponding to a minimum blood oxygenation value and a maximum blood oxygenation value. (Λ)), as well as parameters that numerically represent at least one intermediate reference blood absorption spectrum (A inter (λ));
The calculation software module (310) includes processor-executable code for calculating an oxygen saturation value as a function of the reduced light absorption spectrum for at least two of the reference blood absorption spectra Characterized system.
前記2つの参照血液吸収スペクトルを決定する工程であって、該2つの参照血液吸収スペクトルは、前記低減した光吸収スペクトルに最も近接しているが、それぞれ該低減した光吸収スペクトルよりも大きいスペクトル、および該低減した光吸収スペクトルよりも小さいスペクトルである、工程;ならびに
該最も近接している参照血液吸収スペクトルに関する該低減した光吸収スペクトルの一次補間によって、前記酸素飽和度の値を計算する工程
のための、プロセッサで実行可能なコードをさらに含むことによって特徴付けられる、システム。 20. A system according to any of claims 13 to 19, wherein the calculation software module (310) is:
Determining the two reference blood absorption spectra, wherein the two reference blood absorption spectra are closest to the reduced light absorption spectrum but are each larger than the reduced light absorption spectrum; And a spectrum smaller than the reduced light absorption spectrum; and calculating the value of the oxygen saturation by linear interpolation of the reduced light absorption spectrum with respect to the closest reference blood absorption spectrum A system characterized by further including code executable on the processor.
前記光源(301)であって、少なくとも1つの安定な白色LEDを備える、光源;
保存媒体(320)であって、該白色LEDのスペクトルを特徴付ける予め決定されたパラメータを保存し、該特徴付けられたパラメータは、該白色LEDのスペクトルの関数として、前記低減した光吸収スペクトルを調整するために有用な前記計算ソフトウェアモジュール(310)への入力を形成する、保存媒体
によって特徴付けられる、システム。 23. A system according to any of claims 13 to 22, wherein:
Said light source (301) comprising at least one stable white LED;
A storage medium (320) for storing predetermined parameters characterizing the spectrum of the white LED, the characterized parameter adjusting the reduced light absorption spectrum as a function of the spectrum of the white LED A system characterized by a storage medium that forms an input to the calculation software module (310) useful for:
白色LEDのスペクトルを特徴付けるパラメータを予め決定する工程;
非揮発性のコンピュータで読み取り可能な媒体(320)に該予め決定されたパラメータを保存する工程;
該媒体を該白色LEDと一緒に提供することによって、白色LEDのスペクトルを特徴付ける予め決定されたパラメータの関数として、該装置にその測定を調整するための入力データを提供し、それによってさらなる光源の特徴付けを必要としない、工程
を包含する、方法。 A method in a medical device for performing at least one measurement by directing white light in or on a patient's body to determine at least one body characteristic, the method comprising:
Pre-determining parameters characterizing the spectrum of the white LED;
Storing the predetermined parameters on a non-volatile computer readable medium (320);
Providing the medium with the white LED provides the device with input data to adjust its measurements as a function of predetermined parameters characterizing the spectrum of the white LED, thereby providing additional light source A method comprising a process that does not require characterization.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0322545A GB0322545D0 (en) | 2003-09-26 | 2003-09-26 | Measurement of blood oxygen saturation (SO2) |
PCT/US2004/031321 WO2005030049A1 (en) | 2003-09-26 | 2004-09-24 | Measurement of blood oxygen saturation |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2007506522A JP2007506522A (en) | 2007-03-22 |
JP2007506522A5 true JP2007506522A5 (en) | 2007-11-08 |
Family
ID=29286874
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006528188A Pending JP2007506522A (en) | 2003-09-26 | 2004-09-24 | Measurement of blood oxygen saturation |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1670355A1 (en) |
JP (1) | JP2007506522A (en) |
AU (1) | AU2004275800A1 (en) |
CA (1) | CA2538571A1 (en) |
GB (1) | GB0322545D0 (en) |
WO (1) | WO2005030049A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005063263A1 (en) * | 2005-12-30 | 2007-07-05 | Opsolution Mobile Gmbh | Measurement result generating method for use in e.g. transmissive spectroscopic application, involves processing compensation function representing dependency of distribution of lights by temperature of diode, within signal processing |
US7519407B2 (en) | 2006-02-21 | 2009-04-14 | Physical Logic Ag | Optical sensing catheter system |
DK2034893T3 (en) * | 2006-05-30 | 2014-12-15 | Univ Massachusetts | Measurement of tissue oxygenation |
US8496609B2 (en) | 2007-07-05 | 2013-07-30 | Baxter International Inc. | Fluid delivery system with spiked cassette |
US20130310668A1 (en) * | 2010-10-08 | 2013-11-21 | Edwards Lifesciences Corporation | System, method and computer program product for optical measurement of blood parameters |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2815074C2 (en) * | 1978-04-07 | 1983-03-03 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Spectrophotometers for medical purposes |
DE3328862A1 (en) * | 1982-09-16 | 1985-02-28 | Siemens AG, 1000 Berlin und 8000 München | Tissue photometry method and device, in particular for quantatively determining the blood oxygen saturation from photometric measurements |
JP2898489B2 (en) * | 1991-12-17 | 1999-06-02 | アー・フアウ・エル・メデイカル・インストルメンツ・アクチエンゲゼルシヤフト | Equipment for spectrophotometric analysis |
US5355880A (en) * | 1992-07-06 | 1994-10-18 | Sandia Corporation | Reliable noninvasive measurement of blood gases |
EP1598003A3 (en) * | 1998-08-13 | 2006-03-01 | Whitland Research Limited | Optical device |
-
2003
- 2003-09-26 GB GB0322545A patent/GB0322545D0/en not_active Ceased
-
2004
- 2004-09-24 AU AU2004275800A patent/AU2004275800A1/en not_active Abandoned
- 2004-09-24 WO PCT/US2004/031321 patent/WO2005030049A1/en active Application Filing
- 2004-09-24 EP EP04784948A patent/EP1670355A1/en not_active Withdrawn
- 2004-09-24 JP JP2006528188A patent/JP2007506522A/en active Pending
- 2004-09-24 CA CA002538571A patent/CA2538571A1/en not_active Abandoned
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