JP2007326839A - Health food products with an aim to improve diabetes, periodontal diseases and arthritis - Google Patents
Health food products with an aim to improve diabetes, periodontal diseases and arthritis Download PDFInfo
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- JP2007326839A JP2007326839A JP2006183869A JP2006183869A JP2007326839A JP 2007326839 A JP2007326839 A JP 2007326839A JP 2006183869 A JP2006183869 A JP 2006183869A JP 2006183869 A JP2006183869 A JP 2006183869A JP 2007326839 A JP2007326839 A JP 2007326839A
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Abstract
Description
本発明は、糖尿病、歯周病および関節痛を改善する機能をもつ経口組成物、健康食品に関する。The present invention relates to an oral composition and a health food having a function of improving diabetes, periodontal disease and joint pain.
まず、糖尿病に関して、厚生労働省糖尿病実態調査報告(平成14年)によると、「糖尿病が強く疑われる人」は約740万人、「糖尿病の可能性を否定できない人」は約880万人と推計され、両者を合計すると約1,620万人で、成人の6人に1人は糖尿病かその予備軍であることがわかる。First, regarding diabetes, according to the Ministry of Health, Labor and Welfare Diabetes Survey Report (2002), it is estimated that there are about 7.4 million people who are strongly suspected of diabetes and about 8.8 million people who cannot deny the possibility of diabetes. In total, the number of both is about 16.2 million. One in every six adults is diabetic or a reserve.
糖尿病に対する治療としては、食事療法や運動療法、薬物療法(血糖を下げる薬、糖分の吸収を遅らせる薬、インスリンの働きを良くする薬などの内服薬とインスリン注射)が行われる。薬物療法においては、薬の副作用や注射による苦痛といった不都合が生じる。Treatment for diabetes includes diet therapy, exercise therapy, and pharmacotherapy (internal medicines such as drugs that lower blood sugar, drugs that delay absorption of sugar, drugs that improve the function of insulin, and insulin injection). In drug therapy, inconveniences such as side effects of drugs and pain caused by injection occur.
次に、歯周病に関して、厚生労働省日本歯科疾患実態調査(平成11年版)によると43歳以上で8割、50歳以上では9割が歯周病に罹患しているといわれている。最近では、歯周病が口腔癌、心臓疾患、脳梗塞、骨粗鬆症、早産、糖尿病、呼吸器感染症などの慢性疾患と関連しており、歯周病は全身性疾患であり、単に口腔内にその症状が現れているにすぎないと考えられている。Next, regarding periodontal disease, according to the Ministry of Health, Labor and Welfare Japan Dental Disease Survey (1999 version), it is said that 80% of those aged 43 and over and 90% of those aged 50 and over are affected by periodontal disease. Recently, periodontal disease has been associated with chronic diseases such as oral cancer, heart disease, cerebral infarction, osteoporosis, premature birth, diabetes and respiratory infections. It is thought that the symptom only appears.
歯周病の主たる治療方法は、SRP、抗生物質、及び外科処置であるが、臨床的研究により、SRP処置の効果が不十分なケースが少なくないということが分かっている。SRPは局所的な方法であり、歯周病の全身性については何も処置を施していない。抗生物質は一時的な助けになるが、再発を防止することはできない。外科処置は最終手段として位置づけられているが、痛みを伴い、高額な費用がかかる。The main treatments for periodontal disease are SRP, antibiotics, and surgical procedures, but clinical studies have shown that there are many cases where the effectiveness of SRP treatment is inadequate. SRP is a local method and does not provide any treatment for the systemic nature of periodontal disease. Antibiotics provide temporary help but cannot prevent recurrence. Although surgical procedures are positioned as a last resort, they are painful and expensive.
次に、関節炎に関して、厚生労働省国民生活基礎調査(平成4年)によれば、「手足の関節が痛む者」、すなわちリウマチの訴えのある者は230万人に達し、厚生省長期慢性疾患総合研究事業平成9年度研究報告書によれば、関節リウマチの有病率は0.33%で全国患者数は約60万人と推計されている。Next, regarding arthritis, according to the Ministry of Health, Labor and Welfare National Life Survey (1992), there were 2.3 million people who suffered from rheumatoid arthritis. According to the research report for fiscal 1997, the prevalence of rheumatoid arthritis is 0.33% and the number of patients in Japan is estimated to be about 600,000.
このような症状がみられるものとしては、変形性股関節症、変形性膝関節症のような変形性関節症(OA)、慢性関節リウマチ(RA)などの関節痛などがあげられる。このような症状に対する治療としては、非ステロイド性抗炎症薬(消炎鎮痛剤)、抗リウマチ薬、副腎皮質ステロイド剤(ステロイド)、免疫調節剤などによる薬物治療や温熱療法、体操と筋力強化、補装具の装着といった理学療法などのリハビリテーション、人工関節手術のような外科的治療が行われる。Examples of such symptoms include osteoarthritis (OA) such as osteoarthritis of the hip, knee osteoarthritis, and joint pain such as rheumatoid arthritis (RA). Treatment for such symptoms includes non-steroidal anti-inflammatory drugs (anti-inflammatory analgesics), anti-rheumatic drugs, corticosteroids (steroids), immunomodulators, etc., thermotherapy, gymnastics and muscle strength, supplementation Rehabilitation such as physical therapy such as wearing a brace and surgical treatment such as artificial joint surgery are performed.
このような治療方法は、副作用を生じたり患者に苦痛を与えたりするなどの不都合があるし、原因が不明であるために根本的に治療することは難しい。また、痛みがそれほど重症でない場合には、湿布などにより家庭内で処置をしたり、我慢したりすることも多い。Such a treatment method has inconveniences such as causing side effects and causing pain to the patient, and since the cause is unknown, it is difficult to fundamentally treat. Moreover, when the pain is not so severe, it is often treated or put up in the home with a compress.
最近になって、これら3つの疾病に共通している根本的な原因として、微小循環の血流の滞り、活性酸素の過剰産生による組織の炎症が指摘されている。Recently, the root causes common to these three diseases have been pointed out as stagnant microcirculation blood flow and tissue inflammation due to excessive production of active oxygen.
ボスウェリア セラータ(Boswellia serrata)(カンラン科)は、インドの乾燥した丘陵地域に豊富に生えている枝を広げた落葉性の大きな木である。これは「Dhup」、インドトスゴム(Indian Frankincense)またはインドオリバナム(Indian Olibanum)として知られている。土地ことばで「Salai guggal」で知られているボスウェリアセラータ(Boswellia serrata)のゴム樹脂滲出液は、アーユルヴェーダの薬の規則において、リウマチ、呼吸性疾患、および肝障害の管理に使われている。現代医学におけるボスウェリア セラータ(Boswellia serrata)の主な利用は抗関節炎および抗炎症性の薬理学的薬剤としてのものである。Boswellia serrata (Orchidaceae) is a large, deciduous tree with abundant branches growing in the dry hills of India. This is known as “Dhup”, Indian Frankincense or Indian Olivenum. Boswellia serrata rubber resin exudate, known as “Salai guggal” in the local language, is used in the management of rheumatism, respiratory disease, and liver damage in the Ayurvedic drug regulations . The main use of Boswellia serrata in modern medicine is as an anti-arthritic and anti-inflammatory pharmacological agent.
明日葉、ケール、緑茶葉、ブドウ種子抽出物に含まれるポリフェノール、α−リポ酸、ビタミンCは抗酸化作用を持つことが知られている。また、亜鉛は体内で強い抗酸化作用を持つSOD(Superoxide Dismutase)の構成物質の1つである。It is known that polyphenols, α-lipoic acid and vitamin C contained in tomorrow leaves, kale, green tea leaves, and grape seed extract have an antioxidant effect. Zinc is one of the constituents of SOD (Superoxide Dismutase) that has a strong antioxidant action in the body.
以上のように、上記の素材はそれぞれ抗炎症作用、微小循環改善作用あるいは抗酸化作用が確認されている。しかし、これらの素材を組み合わせることで、糖尿病、歯周病および関節炎が大幅に改善するという報告はない。As described above, each of the above materials has been confirmed to have an anti-inflammatory action, a microcirculation improving action or an antioxidant action. However, there is no report that diabetes, periodontal disease, and arthritis are significantly improved by combining these materials.
糖尿病、歯周病および関節炎の共通の原因と考えられる微小循環の滞り、活性酸素の過剰産生による組織の炎症を改善する働きを持ち、糖尿病、歯周病および関節炎に対応した食品の提供が求められている。本発明は、微小循環の改善効果、抗酸化作用、抗炎症作用が確認されている素材を組み合わせることで、糖尿病、歯周病および関節炎などに効果的な健康食品を提供することをその目的とする。It is necessary to provide food for diabetes, periodontal disease, and arthritis that has the function of improving microcirculation stagnation, a common cause of diabetes, periodontal disease and arthritis, and tissue inflammation due to excessive production of active oxygen. It has been. The object of the present invention is to provide an effective health food for diabetes, periodontal disease, arthritis, and the like by combining materials that have been confirmed to have microcirculation improving effects, antioxidant effects, and anti-inflammatory effects. To do.
本発明は、種々検討した結果、ボスウェリアセラータ、明日葉、ケール、緑茶葉、緑茶葉、亜鉛・モリブデンを含む酵母、α−リポ酸、およびビタミンC、ビタミンB群の併用摂取が、微小循環の滞り、活性酸素の過剰産生による組織の炎症を改善する働きを持ち、糖尿病、歯周病および関節炎を改善する効果があることを見出した。As a result of various studies, the present invention shows that Boswellia serrata, tomorrow leaves, kale, green tea leaves, green tea leaves, yeast containing zinc / molybdenum, α-lipoic acid, and vitamin C and vitamin B group combined intake are microcirculation. It has been found that it has a function of improving tissue inflammation due to stagnation and excessive production of active oxygen, and has an effect of improving diabetes, periodontal disease and arthritis.
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20090312A1 (en) * | 2009-03-04 | 2010-09-05 | Forem Pharma S R L | COMPOSITION OF FOOD PARTICULARLY FOR THE PREVENTION AND TREATMENT OF NEUROPATHY IN DIABETIC PATIENTS. |
WO2013042378A1 (en) * | 2011-09-22 | 2013-03-28 | 株式会社ロッテ | Deodorant composition |
JP2013537894A (en) * | 2010-09-22 | 2013-10-07 | フラウンホフェル−ゲゼルシャフト ツ−ル フォルダルング デル アンゲバンドテン フォルシュング エー.ファウ. | Use of boswellic acid for the prevention and / or treatment of damage and / or inflammation of the islets of Langerhans |
KR20170082576A (en) * | 2014-11-06 | 2017-07-14 | 엔더블유오 스템 큐어, 엘엘씨 | Nutraceutical supplement with lactobacillus rhamnosus |
-
2006
- 2006-06-06 JP JP2006183869A patent/JP2007326839A/en active Pending
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20090312A1 (en) * | 2009-03-04 | 2010-09-05 | Forem Pharma S R L | COMPOSITION OF FOOD PARTICULARLY FOR THE PREVENTION AND TREATMENT OF NEUROPATHY IN DIABETIC PATIENTS. |
JP2013537894A (en) * | 2010-09-22 | 2013-10-07 | フラウンホフェル−ゲゼルシャフト ツ−ル フォルダルング デル アンゲバンドテン フォルシュング エー.ファウ. | Use of boswellic acid for the prevention and / or treatment of damage and / or inflammation of the islets of Langerhans |
EP3338773A1 (en) * | 2010-09-22 | 2018-06-27 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Use of boswellic acids for the prophylaxis and/or treatment of damages and/or inflammation of the islets of langerhans |
WO2013042378A1 (en) * | 2011-09-22 | 2013-03-28 | 株式会社ロッテ | Deodorant composition |
JP2013067585A (en) * | 2011-09-22 | 2013-04-18 | Lotte Co Ltd | Deodorant composition |
CN103826650A (en) * | 2011-09-22 | 2014-05-28 | 罗蒂株式会社 | Deodorant composition |
KR20170082576A (en) * | 2014-11-06 | 2017-07-14 | 엔더블유오 스템 큐어, 엘엘씨 | Nutraceutical supplement with lactobacillus rhamnosus |
JP2017535289A (en) * | 2014-11-06 | 2017-11-30 | エヌダブリューオー ステム キュア、エルエルシー | Dietary supplements containing Lactobacillus rhamnosus |
KR101971809B1 (en) | 2014-11-06 | 2019-04-23 | 엔더블유오 스템 큐어, 엘엘씨 | Nutraceutical supplement with lactobacillus rhamnosus |
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