JP2007262229A - Aqueous pigment dispersion and skin care preparation containing the same - Google Patents
Aqueous pigment dispersion and skin care preparation containing the same Download PDFInfo
- Publication number
- JP2007262229A JP2007262229A JP2006088773A JP2006088773A JP2007262229A JP 2007262229 A JP2007262229 A JP 2007262229A JP 2006088773 A JP2006088773 A JP 2006088773A JP 2006088773 A JP2006088773 A JP 2006088773A JP 2007262229 A JP2007262229 A JP 2007262229A
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- JP
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- Prior art keywords
- dispersion
- acid
- aqueous pigment
- pigment dispersion
- alkali
- Prior art date
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- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 229940114937 microcrystalline wax Drugs 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- CKQVRZJOMJRTOY-UHFFFAOYSA-N octadecanoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.CCCCCCCCCCCCCCCCCC(O)=O CKQVRZJOMJRTOY-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920002432 poly(vinyl methyl ether) polymer Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 229920003170 water-soluble synthetic polymer Polymers 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- 229910001928 zirconium oxide Inorganic materials 0.000 description 1
Landscapes
- Pigments, Carbon Blacks, Or Wood Stains (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
Description
本発明は、水系顔料分散物及びそれを含有する皮膚外用剤に関するものである。 The present invention relates to an aqueous pigment dispersion and an external preparation for skin containing the same.
従来の水系顔料分散物としては、無機金属酸化物粉体を化粧料用等顔料として用いたものが、ファンデーション、アイシャドー、ほお紅等のメイクアップ化粧料や、サンスクリーン化粧料、乳液、クリーム等の基礎化粧料、又は医薬品等の皮膚外用剤として使用されている。しかし、これらは顔料が水中で凝集沈降し易く、水系での分散性が悪いという問題点を有していた。 As conventional water-based pigment dispersions, those using inorganic metal oxide powder as cosmetic pigments, makeup cosmetics such as foundations, eye shadows, blushers, sunscreen cosmetics, emulsions, creams, etc. It is used as an external skin preparation for basic cosmetics and pharmaceuticals. However, these have the problem that the pigment is easily aggregated and settled in water and the dispersibility in water is poor.
このような問題点を解決するために、例えば、二酸化チタン粒子をポリカルボン酸系分散剤の存在下で分散させて水性分散体を得る方法が提案されている（特開平０２−２１２３１５号公報）。また、ポリオキシエチレン系非イオン性界面活性剤で分散する方法（特開平０７−２４７１１９号公報）が開示されている。
しかしながら、特開平０２−２１２３１５号公報に記載のようにポリカルボン酸系分散剤で分散させた場合には、固形分濃度の低いものしか得られず、また、電解質の存在する系では凝集を起こしやすく、再分散性が悪いという問題があった。 However, when dispersed with a polycarboxylic acid-based dispersant as described in JP-A-02-212315, only those having a low solid content concentration can be obtained, and in a system where an electrolyte is present, aggregation occurs. There was a problem that it was easy and redispersibility was bad.
また、特開平０７−２４７１１９号公報に開示されたポリオキシエチレン系非イオン性界面活性剤で分散する方法では、顔料を疎水化処理する必要があり、本来油分散性の疎水化顔料を水系に分散させているため、分散安定性に問題があった。 Further, in the method of dispersing with a polyoxyethylene nonionic surfactant disclosed in JP-A-07-247119, it is necessary to hydrophobize the pigment, and the originally oil-dispersible hydrophobized pigment is made water-based. Since it was dispersed, there was a problem in dispersion stability.
また、いずれの場合にも分散物を得るために、ハンマーミル、サンドミルなどの粉砕機を用いて粉砕する必要があった。 In any case, in order to obtain a dispersion, it was necessary to grind using a grinder such as a hammer mill or a sand mill.
本発明は、上記に鑑みて、分散性が高く、経時的に凝集を起こさず、分散安定性に優れ、あるいは沈降したとしても再分散性の良好な水系顔料分散物であって、強力な粉砕機を用いることなく調製できる水系顔料分散物を提供することを目的とする。また、分散性、分散安定性に優れた皮膚外用剤を提供することを目的とする。 In view of the above, the present invention is an aqueous pigment dispersion that has high dispersibility, does not cause aggregation over time, has excellent dispersion stability, or has good redispersibility even when settled, and has a powerful pulverization. An object is to provide an aqueous pigment dispersion which can be prepared without using a machine. Moreover, it aims at providing the skin external preparation excellent in the dispersibility and dispersion stability.
本発明の水系顔料分散物は、上記の課題を解決するために、１）無機顔料、２）非イオン性界面活性剤、３）酸及び４）アルカリを含有してなり、前記酸及びアルカリのうちのいずれか一方を添加して無機顔料を分散させた後、酸及びアルカリのうちの他方を添加したものとする。 In order to solve the above-mentioned problems, the aqueous pigment dispersion of the present invention contains 1) an inorganic pigment, 2) a nonionic surfactant, 3) an acid, and 4) an alkali. One of them is added to disperse the inorganic pigment, and then the other of acid and alkali is added.
非イオン性界面活性剤は、ショ糖脂肪酸エステル及びポリグリセリン脂肪酸エステルからなる群から選ばれた１種又は２種以上であることが好ましい。 The nonionic surfactant is preferably one or more selected from the group consisting of sucrose fatty acid esters and polyglycerin fatty acid esters.
本発明の皮膚外用剤は、上記本発明の水系顔料分散物を含有してなるものとする。 The skin external preparation of the present invention contains the aqueous pigment dispersion of the present invention.
本発明の水系顔料分散物は、分散性が高く、経時的に凝集を起こさず、分散安定性に優れ、あるいは沈降したとしても再分散性の良好なものとなる。また、強力な粉砕機を用いることなく得ることができる。本発明の水系顔料分散物を配合することにより、分散性、分散安定性に優れた皮膚外用剤が得られる。 The water-based pigment dispersion of the present invention has high dispersibility, does not cause aggregation over time, has excellent dispersion stability, or has good redispersibility even if it settles. Moreover, it can obtain without using a powerful grinder. By blending the aqueous pigment dispersion of the present invention, a skin external preparation excellent in dispersibility and dispersion stability can be obtained.
本発明の水系顔料分散物及び皮膚外用剤に使用する成分等について以下に説明する。 The components used in the aqueous pigment dispersion and the skin external preparation of the present invention will be described below.
［非イオン性界面活性剤］
本発明で用いる非イオン性界面活性剤の例としては、ポリオキシエチレンアルキルエステル、ポリオキシエチレンアルキルエーテル、ポリオキシエチレンソルビタン脂肪酸エステル、アルキルポリグルコシド、ショ糖脂肪酸エステル、ポリグリセリン脂肪酸エステル、ポリオキシエチレン硬化ヒマシ油、ポリエーテル変性シリコーンなどが挙げられる。
[Nonionic surfactant]
Examples of the nonionic surfactant used in the present invention include polyoxyethylene alkyl ester, polyoxyethylene alkyl ether, polyoxyethylene sorbitan fatty acid ester, alkyl polyglucoside, sucrose fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene Examples include ethylene hydrogenated castor oil and polyether-modified silicone.
非イオン性界面活性剤のＨＬＢは限定されないが、水系であるため、活性剤全体としてＨＬＢ９以上であることが望ましい。一般に非イオン性界面活性剤はイオン性界面活性剤に比べて安全性に優れるが、中でもショ糖脂肪酸エステル、ポリグリセリン脂肪酸エステルが特に好ましい。 Although HLB of a nonionic surfactant is not limited, since it is aqueous, it is desirable that it is HLB9 or more as a whole active agent. In general, nonionic surfactants are superior to ionic surfactants in safety, but sucrose fatty acid esters and polyglycerin fatty acid esters are particularly preferable.
配合量は無機顔料に対して１〜５０ｗｔ％が好ましく、より好ましくは５〜２０ｗｔ％である。１ｗｔ％未満では十分な分散安定性が得られず、一方、５０ｗｔ％を超えても効果の変化は見られず、界面活性剤により系の粘度が高くなりすぎることがある。 The blending amount is preferably 1 to 50 wt%, more preferably 5 to 20 wt% with respect to the inorganic pigment. If the amount is less than 1 wt%, sufficient dispersion stability cannot be obtained. On the other hand, if the amount exceeds 50 wt%, the effect is not changed, and the viscosity of the system may become too high due to the surfactant.
［無機顔料］
無機顔料は、従来から化粧料、医薬品等の皮膚外用剤に用いられるものが特に制限なく用いられ、例として、酸化チタン、ベンガラ、黄酸化鉄、黒酸化鉄、群青、亜鉛華、酸化マグネシウム、酸化ジルコニウム、マイカ、セリサイト、タルク、シリカ、カオリン、炭酸カルシウム、水酸化クロム、ケイ酸マグネシウム、酸化アルミニウム、硫酸バリウム、チタン被覆雲母等が挙げられる。配合量は分散物中に６０ｗｔ％以下が好ましい。６０ｗｔ％を超えると分散媒の量が少なく、均一化することが困難になる。下限は特になく、目的に応じて定めればよい。
[Inorganic pigments]
As the inorganic pigment, those conventionally used for skin external preparations such as cosmetics and pharmaceuticals are used without particular limitation. Examples thereof include titanium oxide, bengara, yellow iron oxide, black iron oxide, ultramarine, zinc white, magnesium oxide, Examples thereof include zirconium oxide, mica, sericite, talc, silica, kaolin, calcium carbonate, chromium hydroxide, magnesium silicate, aluminum oxide, barium sulfate, and titanium-coated mica. The blending amount is preferably 60 wt% or less in the dispersion. If it exceeds 60 wt%, the amount of the dispersion medium is small and it becomes difficult to make it uniform. There is no particular lower limit, and it may be determined according to the purpose.
［酸、アルカリ］
本発明における酸及びアルカリは、無機顔料の分散を容易にするために必須である。分散のために酸またはアルカリの一方を添加し、分散後に系のｐＨを調整するため他方を添加し、最終的には両方の添加が必要である。
[Acid, alkali]
The acid and alkali in the present invention are essential for facilitating dispersion of the inorganic pigment. One of acid or alkali is added for dispersion, the other is added to adjust the pH of the system after dispersion, and finally both are necessary.
酸は特に限定されないが、皮膚外用剤に使用することを考慮すると有機酸であることが好ましい。有機酸の例としては、クエン酸、乳酸、リンゴ酸などが挙げられる。 The acid is not particularly limited, but is preferably an organic acid in consideration of use in a skin external preparation. Examples of organic acids include citric acid, lactic acid, malic acid and the like.
アルカリも皮膚外用剤に使用できるものであれば特に限定されない。ＮａＯＨ、ＫＯＨ、トリエタノールアミン等のアミン類、アルギニン等の塩基性アミノ酸が挙げられる。 The alkali is not particularly limited as long as it can be used as a skin external preparation. Examples include amines such as NaOH, KOH and triethanolamine, and basic amino acids such as arginine.
配合量は、酸、アルカリの種類により異なるが、分散物中に各々０．００５〜１０ｗｔ％が好ましく、より好ましくは０．０１〜２ｗｔ％である。配合量が少ないと顔料の分散性が悪く、１０ｗｔ％を超えて配合しても分散性の改善効果は見られない。 The blending amount varies depending on the types of acid and alkali, but 0.005 to 10 wt% is preferable in the dispersion, and more preferably 0.01 to 2 wt%. If the blending amount is small, the dispersibility of the pigment is poor, and even if the blending amount exceeds 10 wt%, the effect of improving the dispersibility is not seen.
［水溶性高分子］
本発明の水系顔料分散物は、水溶性高分子をさらに含有することが好ましい。水溶性高分子を用いることにより顔料の経時的分散安定性が改善される。
[Water-soluble polymer]
The aqueous pigment dispersion of the present invention preferably further contains a water-soluble polymer. By using the water-soluble polymer, the dispersion stability of the pigment over time is improved.
水溶性高分子としては特に限定されるものではなく、デキストリン、キサンタンガム等の微生物系多糖類、デンプン、グアーガム、カラギーナン、寒天、マンナン等の植物系多糖類、ゼラチン、カゼイン、アルブミン、コラーゲン等の動物系蛋白質などの天然高分子、また、半合成高分子としては、メチルセルロース、エチルセルロース、カルボキシメチルセルロースナトリウム、ヒドロキシエチルセルロース、カチオン化セルロース等のセルロース系、可溶性デンプン、メチルデンプン等のデンプン系、アルギン酸塩、アルギン酸プロピレングリコールエステル等のアルギン酸系が挙げられる。水溶性合成高分子の例としては、ポリビニルピロリドン、ポリエチレングリコール、ポリビニルアルコール、カルボキシビニルポリマー、ポリアクリル酸ナトリウム、ポリアクリル酸アンモニウム、ポリビニルメチルエーテル等が挙げられる。 The water-soluble polymer is not particularly limited, and microbial polysaccharides such as dextrin and xanthan gum, plant polysaccharides such as starch, guar gum, carrageenan, agar and mannan, animals such as gelatin, casein, albumin and collagen. Natural polymers such as proteins, and semi-synthetic polymers include celluloses such as methylcellulose, ethylcellulose, sodium carboxymethylcellulose, hydroxyethylcellulose, and cationized cellulose, starches such as soluble starch and methylstarch, alginate, and alginic acid. Examples include alginic acid type such as propylene glycol ester. Examples of the water-soluble synthetic polymer include polyvinyl pyrrolidone, polyethylene glycol, polyvinyl alcohol, carboxyvinyl polymer, sodium polyacrylate, ammonium polyacrylate, polyvinyl methyl ether and the like.
水溶性高分子の配合量は分散物中に０．０１〜１０ｗｔ％が好ましく、より好ましくは０．０５〜５ｗｔ％である。０．０１ｗｔ％以下では所望の安定化効果が得られず、１０ｗｔ％を超えると系の増粘が著しく好ましくない。 The blending amount of the water-soluble polymer is preferably 0.01 to 10 wt%, more preferably 0.05 to 5 wt% in the dispersion. If it is 0.01 wt% or less, the desired stabilizing effect cannot be obtained, and if it exceeds 10 wt%, the thickening of the system is extremely undesirable.
［その他の成分］
本発明の水系顔料分散物及びこれを用いた皮膚外用剤には、本発明の趣旨を損なわない範囲内で、従来から同種の製品に用いられている添加物を必要に応じて添加することができる。例えば、流動パラフィン、ワセリン、マイクロクリスタリンワックス、スクワラン、ホホバ油、ミツロウ、カルナウバロウ、ラノリン、オリーブ油、ヤシ油、高級アルコール、脂肪酸、高級アルコールと脂肪酸のエステル、シリコーン油等の油性成分、グリセリン、ソルビトール、キシリトール、マルチトール、プロピレングリコール、ポリエチレングリコール、１，３−ブチレングリコール等の保湿剤、ベントナイト等の粘土鉱物、各種ビタミン及びその誘導体、アラントイン、グリチルリチン酸及びその誘導体、各種動植物抽出物等の薬効成分、エタノール、紫外線吸収剤、色素、防腐剤、顔料、粉体、ｐＨ調整剤、抗酸化剤、香料等を適宜配合することができる。
[Other ingredients]
In the aqueous pigment dispersion of the present invention and the external preparation for skin using the same, additives conventionally used in the same kind of products may be added as necessary within the range not impairing the gist of the present invention. it can. For example, liquid paraffin, petrolatum, microcrystalline wax, squalane, jojoba oil, beeswax, carnauba wax, lanolin, olive oil, coconut oil, higher alcohol, fatty acid, higher alcohol and fatty acid ester, silicone oil and other oil components, glycerin, sorbitol, Moisturizers such as xylitol, maltitol, propylene glycol, polyethylene glycol, 1,3-butylene glycol, clay minerals such as bentonite, various vitamins and derivatives thereof, allantoin, glycyrrhizic acid and derivatives thereof, various animal and plant extracts Ethanol, ultraviolet absorbers, dyes, preservatives, pigments, powders, pH adjusters, antioxidants, fragrances and the like can be appropriately blended.
［調製方法］
本発明の水系顔料分散物は、例えば次の方法により調製することができる。
[Preparation method]
The aqueous pigment dispersion of the present invention can be prepared, for example, by the following method.
まず水に無機顔料と酸（又はアルカリ）を加えて均一に分散する。次に非イオン性界面活性剤を加え、必要であれば加熱して均一化する。その後、アルカリ（又は酸）を加えてｐＨを調整して水系顔料分散物を得る。水溶性高分子を加える場合は、ｐＨを調整する以前に加えておくことが好ましい。 First, an inorganic pigment and an acid (or alkali) are added to water and dispersed uniformly. Next, a nonionic surfactant is added, and if necessary, heated to homogenize. Thereafter, alkali (or acid) is added to adjust the pH to obtain an aqueous pigment dispersion. When adding a water-soluble polymer, it is preferable to add it before adjusting pH.
［皮膚外用剤］
本発明でいう皮膚外用剤とは、ファンデーション、アイシャドー、ほお紅等のメイクアップ化粧料や、サンスクリーン化粧料、乳液、クリーム等の基礎化粧料、又は医薬品等の顔料を含有する皮膚塗布剤である。
[Skin external preparation]
The topical skin preparation as used in the present invention is a skin coating agent containing a makeup cosmetic such as foundation, eye shadow, blush, etc., a basic cosmetic such as sunscreen cosmetics, milky lotion or cream, or a pigment such as pharmaceuticals. is there.
本発明の皮膚外用剤の剤型は特に限定されず、固形状、クリーム状、ペースト状、乳化状、ローション状などの種々の剤型をとり得る。特にメイクアップ化粧料、サンスクリーン剤などに本発明は有用である。 The dosage form of the external preparation for skin of the present invention is not particularly limited, and various dosage forms such as a solid form, a cream form, a paste form, an emulsified form, and a lotion form can be taken. The present invention is particularly useful for makeup cosmetics, sunscreen agents and the like.
本発明の皮膚外用剤における前記無機顔料の配合量は、その化粧料の特質に応じて任意に選択されるものであるが、官能上の特性および効果の発現を考慮すると、０．１〜６０ｗｔ％とするのが好ましい。 The blending amount of the inorganic pigment in the external preparation for skin of the present invention is arbitrarily selected according to the characteristics of the cosmetic, but it is 0.1 to 60 wt in consideration of the development of sensory characteristics and effects. % Is preferable.
以下、本発明の実施例を説明するが、本発明は以下の実施例によって限定されるものではない。 Examples of the present invention will be described below, but the present invention is not limited to the following examples.
１．水系顔料分散物の調製
表１に示す各成分を用いて以下の方法で、水系顔料分散物を調製した。
1. Preparation of water-based pigment dispersion Water-based pigment dispersions were prepared by the following methods using the components shown in Table 1.
調製方法：成分３に成分８を溶解させ、成分１，２，６，７を加えてホモミキサー（プライミクス株式会社製）で攪拌して均一分散させた。成分４，５を加えて７５℃に加温溶解し、さらにホモミキサー（プライミクス株式会社製）で攪拌して均一分散させた。別に７５℃に加温した成分９〜１２を添加後、成分１３を添加して均一に攪拌した。室温まで冷却して水系顔料分散物を得た。 Preparation method: Component 8 was dissolved in component 3, components 1, 2, 6, and 7 were added, and the mixture was stirred and homogenized with a homomixer (manufactured by PRIMIX Corporation). Ingredients 4 and 5 were added, heated and dissolved at 75 ° C., and further stirred and uniformly dispersed with a homomixer (manufactured by PRIMIX Corporation). Separately, components 9 to 12 heated to 75 ° C. were added, and then component 13 was added and stirred uniformly. The mixture was cooled to room temperature to obtain an aqueous pigment dispersion.
各成分の詳細は以下の通りである；
１，３−ＢＧ 協和発酵ケミカル株式会社：１，３−ブチレングリコール
グリセリン 第一工業製薬株式会社：濃グリセリン
ステアリン酸スクロース 第一工業製薬株式会社：コスメライクＳ−１１０
ポリグリセリン脂肪酸エステル 日光ケミカルズ株式会社：ＮＩＫＫＯＬ Ｄｅｃａｇｌｙｎ １−Ｓ
微粒子酸化チタン 石原産業株式会社：ＴＴＯ−Ｖ−３
微粒子酸化亜鉛 大阪住友セメント株式会社：ＺｎＯ−３５０
クエン酸一水和物 関東化学株式会社：試薬一級
カルボキシメチルセルロースＮａ 第一工業製薬株式会社：セロゲンＦ−ＳＡ
キサンタンガム 大日本製薬株式会社：Ｋ−ＯＢ
ポリビニルピロリドン 第一工業製薬株式会社：クリージャスＫ−９０
水酸化ナトリウム 関東化学株式会社：試薬特級
Details of each component are as follows;
1,3-BG Kyowa Hakko Chemical Co., Ltd .: 1,3-butylene glycol glycerin Daiichi Kogyo Seiyaku Co., Ltd .: concentrated glycerin stearic acid sucrose Daiichi Kogyo Seiyaku Co., Ltd .: Cosmelike S-110
Polyglycerin fatty acid ester Nikko Chemicals Co., Ltd .: NIKKOL Decaglyn 1-S
Fine particle titanium oxide Ishihara Sangyo Co., Ltd .: TTO-V-3
Fine zinc oxide Osaka Sumitomo Cement Co., Ltd .: ZnO-350
Citric acid monohydrate Kanto Chemical Co., Inc .: Reagent grade 1 Carboxymethylcellulose Na Daiichi Kogyo Seiyaku Co., Ltd .: Serogen F-SA
Xanthan gum Dainippon Pharmaceutical Co., Ltd .: K-OB
Polyvinylpyrrolidone Daiichi Kogyo Seiyaku Co., Ltd .: CLEASURE K-90
Sodium hydroxide Kanto Chemical Co., Inc .: reagent grade
得られた分散物の分散性及び経時安定性を以下の基準で評価した。結果を表１に示す。 The dispersibility and temporal stability of the obtained dispersion were evaluated according to the following criteria. The results are shown in Table 1.
分散性：試料を１００ｍｌ円筒管に入れ、一日後の沈降層の比率から評価した；
５：沈降層なし
４：沈降層５％未満
３：沈降層５％以上１０％未満
２：沈降層１０％以上２０％未満
１：沈降層２０％以上
Dispersibility: The sample was put into a 100 ml cylindrical tube and evaluated from the ratio of the sedimented layer after one day;
5: no sedimentation layer 4: sedimentation layer less than 5% 3: sedimentation layer 5% or more and less than 10% 2: sedimentation layer 10% or more but less than 20% 1: sedimentation layer 20% or more
経時安定性：二週間後の沈降層の比率と、円筒管を５回上下反転させた後の沈降層の有無（再分散性）から評価した；
５：沈降層なし
４：沈降層１０％未満かつ再分散可
３：沈降層１０％以上２０％未満かつ再分散可
２：沈降層２０％以上かつ再分散可
１：沈降層２０％以上かつ再分散不可
Stability over time: evaluated from the ratio of the sedimentation layer after 2 weeks and the presence or absence (redispersibility) of the sedimentation layer after the cylindrical tube was inverted up and down 5 times;
5: No sedimentation layer 4: Sedimentation layer less than 10% and redispersible 3: Sedimentation layer 10% or more and less than 20% and redispersion 2: Sedimentation layer 20% or more and redispersion 1: Sedimentation layer 20% or more and redispersion Non-distributable
２．サンスクリーン剤の調製
表２に示す各成分を用いて以下の方法でサンスクリーン剤を調製した。
2. Preparation of sunscreen agent A sunscreen agent was prepared by the following method using each component shown in Table 2.
調製方法：成分１に成分２、３を分散させ、ホモディスパー（プライミクス株式会社製）で攪拌しながら成分４、５を加えた。成分６〜８を加えて、７５℃に加温、溶解させた。成分９〜１１を加え、ホモミキサー（プライミクス株式会社製）で攪拌して均一分散させた。成分１２を添加後、別に７５℃で加温溶解した成分１３、１４をホモミキサー攪拌しながら添加し、均一に攪拌した。室温まで冷却してサンスクリーン剤を得た。 Preparation method: Components 2 and 3 were dispersed in component 1, and components 4 and 5 were added while stirring with a homodisper (manufactured by PRIMIX Corporation). Ingredients 6-8 were added and heated to 75 ° C. and dissolved. Components 9 to 11 were added, and the mixture was stirred and uniformly dispersed with a homomixer (manufactured by PRIMIX Corporation). After adding Component 12, Components 13 and 14, which were separately heated and dissolved at 75 ° C., were added while stirring with a homomixer and stirred uniformly. It cooled to room temperature and obtained the sunscreen agent.
得られたサンスクリーン剤につき分散性及び経時安定性を上記と同様の基準で評価した。結果を表２に示す。 The obtained sunscreen agent was evaluated for dispersibility and temporal stability according to the same criteria as described above. The results are shown in Table 2.
なお、各成分のうち上記実施例で用いていないものの詳細は以下の通りであり、それ以外は上記実施例で用いたのと同じものを使用した；
ベントナイト クニミネ工業株式会社：クニピアＦ
ステアリン酸スクロース１ 第一工業製薬株式会社：コスメライクＳ−１６０
ステアリン酸スクロース２ 第一工業製薬株式会社：コスメライクＳ−１１０
ジステアリン酸スクロース 第一工業製薬株式会社：コスメライクＳ−５０
トリオクタノイン 花王株式会社：エキセパールＴＧＯ
ココアパウダー 大東カカオ株式会社：Ｄココアパウダー
In addition, the detail of what was not used in the said Example among the each component is as follows, and other than that used the same thing as used in the said Example;
Bentonite Kunimine Industry Co., Ltd .: Kunipia F
Sucrose stearate 1 Daiichi Kogyo Seiyaku Co., Ltd .: Cosmelike S-160
Sucrose stearate 2 Daiichi Kogyo Seiyaku Co., Ltd .: Cosmelike S-110
Sucrose distearate Daiichi Kogyo Seiyaku Co., Ltd .: Cosmelike S-50
Trioctanoin Kao Corporation: EXCEPARL TGO
Cocoa Powder Daito Cacao Corporation: D Cocoa Powder
本発明の水系顔料分散物は、ファンデーション、日焼け止め化粧料や、医薬用の皮膚外用剤として用いることができる。
The aqueous pigment dispersion of the present invention can be used as a foundation, a sunscreen cosmetic, or a pharmaceutical skin external preparation.
Claims (3)
前記酸及びアルカリのうちのいずれか一方を添加して無機顔料を分散させた後、酸及びアルカリのうちの他方を添加した
ことを特徴とする水系顔料分散物。 1) an inorganic pigment, 2) a nonionic surfactant, 3) an acid and 4) an alkali,
One of the acid and alkali is added to disperse the inorganic pigment, and then the other of the acid and alkali is added.
A skin external preparation comprising the aqueous pigment dispersion according to claim 1 or 2.
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| JP2006088773A JP2007262229A (en) | 2006-03-28 | 2006-03-28 | Aqueous pigment dispersion and skin care preparation containing the same |
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| JP2006088773A JP2007262229A (en) | 2006-03-28 | 2006-03-28 | Aqueous pigment dispersion and skin care preparation containing the same |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009149568A (en) * | 2007-12-21 | 2009-07-09 | Lion Corp | Dermatological formulation for external use |
| WO2009145344A1 (en) * | 2008-05-30 | 2009-12-03 | 株式会社 資生堂 | Oil‑in‑water type topical agent for skin |
| WO2019146783A1 (en) * | 2018-01-29 | 2019-08-01 | 石原産業株式会社 | Titanium dioxide aqueous dispersion and method for producing same |
| CN111253805A (en) * | 2020-01-08 | 2020-06-09 | 江西联锴科技有限公司 | Water-based nano ferric oxide color paste and preparation method thereof |
-
2006
- 2006-03-28 JP JP2006088773A patent/JP2007262229A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009149568A (en) * | 2007-12-21 | 2009-07-09 | Lion Corp | Dermatological formulation for external use |
| WO2009145344A1 (en) * | 2008-05-30 | 2009-12-03 | 株式会社 資生堂 | Oil‑in‑water type topical agent for skin |
| JP2009286757A (en) * | 2008-05-30 | 2009-12-10 | Shiseido Co Ltd | O/w-type skin care preparation |
| JP4714241B2 (en) * | 2008-05-30 | 2011-06-29 | 株式会社 資生堂 | Oil-in-water topical skin preparation |
| CN102046142B (en) * | 2008-05-30 | 2013-03-27 | 株式会社资生堂 | Oil-in-water type topical agent for skin |
| WO2019146783A1 (en) * | 2018-01-29 | 2019-08-01 | 石原産業株式会社 | Titanium dioxide aqueous dispersion and method for producing same |
| JPWO2019146783A1 (en) * | 2018-01-29 | 2021-01-07 | 石原産業株式会社 | Titanium dioxide aqueous dispersion and its manufacturing method |
| JP7185143B2 (en) | 2018-01-29 | 2022-12-07 | 石原産業株式会社 | Titanium dioxide aqueous dispersion and method for producing the same |
| US11702560B2 (en) | 2018-01-29 | 2023-07-18 | Ishihara Sangyo Kaisha, Ltd. | Titanium dioxide aqueous dispersion and method for producing same |
| CN111253805A (en) * | 2020-01-08 | 2020-06-09 | 江西联锴科技有限公司 | Water-based nano ferric oxide color paste and preparation method thereof |
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