JP2007160296A - Syringe for discharging trace amount of fluid - Google Patents

Syringe for discharging trace amount of fluid Download PDF

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Publication number
JP2007160296A
JP2007160296A JP2005381063A JP2005381063A JP2007160296A JP 2007160296 A JP2007160296 A JP 2007160296A JP 2005381063 A JP2005381063 A JP 2005381063A JP 2005381063 A JP2005381063 A JP 2005381063A JP 2007160296 A JP2007160296 A JP 2007160296A
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syringe
piston
tube
inside diameter
inner diameter
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Minoru Nakamura
稔 中村
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  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Reciprocating Pumps (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)

Abstract

<P>PROBLEM TO BE SOLVED: To provide a chemical resistant syringe that can discharge a trace amount of fluid. <P>SOLUTION: A body 1 has a hardware 2 for reducing its inside diameter attached by a locknut 8 at its end and has the syringe 4 inserted through the penetrating hole 3. The syringe 4 is tube-shaped and made of a transparent resin material such as PFA with its one end narrowed to form a nozzle 5. A round-bar-shaped piston 6 has a little smaller outside diameter than the inside diameter of the syringe 4 and is inserted from an open end 7 of the syringe 4. With the locknut 8 tightened, the body 1 has its inside diameter reduced, holds the syringe 4 tightly and even reduces the inside diameter of the syringe 4 to form a seal part 9. The tightening force of the locknut 8 is adjusted so that the piston 6 may slide back and forth. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

ガス、薬品、接着剤、ペースト等の流体の分析、液送、塗布に於いて微量の吐出、吸入に使用するシリンジに関する。The present invention relates to a syringe used for a small amount of discharge and inhalation in analysis, liquid feeding, and application of fluids such as gas, chemicals, adhesives, and pastes.

近年ＤＮＡ分析、液晶の塗布、メタノールの液送等でナノリットル、ピコリットルの吐出量が要求される。インクジェット方式の吐出はピコリットルを達成している。しかしオイル状、ペースト等の液はインクジェット方式には不向きである。In recent years, nanoliter and picoliter discharge volumes are required for DNA analysis, liquid crystal application, methanol liquid feeding, and the like. Inkjet ejection has achieved picoliters. However, liquids such as oil and paste are not suitable for the ink jet system.

流体の微量吐出装置に於いてシリンジポンプ方式（注射器と同じ構造のシリンジのピストンを押し込んでシリンジ内の液を吐出する方式）が極微量を精度良く吐出でき、高粘度液にも対応できるので多用されている。この微量吐出装置に於いてピストンの送り機構はリニヤスライド、ボールネジ、サーボモーター等を使用してサブミクロンの移動量を確保している。Syringe pump system (a system that pushes the piston of the syringe with the same structure as the syringe and discharges the liquid in the syringe) can discharge a very small amount with high precision and can be used for high viscosity liquids. Has been. In this micro discharge device, the piston feed mechanism uses a linear slide, a ball screw, a servo motor or the like to secure a submicron movement amount.

シリンジもナノリットル、ピコリットルの吐出が可能なものが要求され、シリンジ内径が数１００ミクロンの微小なものが要求される。The syringe is also required to be capable of discharging nanoliters and picoliters, and a syringe having a small inner diameter of several hundred microns is required.

課題Task

現在微量吐出にはガラスシリンジが多用されている。しかしながらガラスシリンジは
▲１▼ 耐薬品性の適、不適が多い。
▲２▼ ガラス筒の精密加工が必要。
▲３▼ 小径になるほどシール製作が困難である。
▲４▼ シールの磨耗が早く、調整も出来ないので耐圧力がばらつく。
▲５▼ 固体粒子を含む液はかじり易い。
▲６▼ 液の充填時に気泡を噛みこみ易く、除去しにくい。
▲７▼ 高価である。
▲８▼ シリンジとノズルは組み立てて使用するので、接合部に気泡が残る。
等の問題がある。金属シリンジや樹脂シリンジも同様である。Currently, glass syringes are frequently used for micro-discharge. However, glass syringes are (1) often suitable and unsuitable for chemical resistance.
(2) Precision processing of the glass tube is required.
(3) The smaller the diameter, the more difficult it is to manufacture the seal.
(4) The seal wears quickly and cannot be adjusted, so the pressure resistance varies.
(5) A liquid containing solid particles is easy to bite.
(6) It is easy to bite and remove bubbles when filling with liquid.
(7) Expensive.
(8) Since the syringe and nozzle are assembled and used, air bubbles remain at the joint.
There are problems such as. The same applies to metal syringes and resin syringes.

解決手段Solution

フッソ樹脂チュウブの一端を細く絞りノズルとし、他端外周にチュウブの外径減少金具を設け、チュウブ内径より若干小径の丸棒状のピストンを挿入し、外径減少金具を調整してチュウブ外内径を減少さしピストンにチュウブを密接さす構造のシリンジを提供する。One end of the fluororesin tube is made into a narrow nozzle, and a tube outer diameter reduction fitting is provided on the outer periphery of the other end. A syringe having a structure in which a tube is closely attached to a reduced piston is provided.

ボデイ１は一端に締め付けナット８を持つ内径減少金具２を形成し、貫通する穴３にシリンジ４を挿入保持している。シリンジ４はＰＦＡ等透明樹脂材のチューブ状とし一端は細径にしてノズル５を形成する。丸棒状のピストン６はシリンジ４の内径より若干細い外径とし、シリンジ４の開放端７より挿入する。締め付けナット８を締めるとボデイ１の内径が減少しシリンジ４を掴着すると共にシリンジ４の内径をも減少さしシール部９を形成する。ピストン６が左右に摺動できる程度に締め付けナット８の締め付け力を加減する。締め付けナット８を緩め、ピストン６を引き抜き、スポイド等でシリンジ４内に液を充填する。再びピストン６を少し挿入し、締め付けナット８を締める。ピストン６をシリンジ４内に少し押し込むと、ピストン６の断面積×押し込み量の体積の液がノズル５より吐出する。例えばピストン直径０．３ミリ、押し込み量０．０１ミリとすると僅か０．７ナノリットルの液を吐出することができる。The body 1 is formed with an inner diameter-reducing metal fitting 2 having a tightening nut 8 at one end, and a syringe 4 is inserted and held in a through-hole 3. The syringe 4 has a tube shape made of a transparent resin material such as PFA, and one end has a small diameter to form the nozzle 5. The round rod-shaped piston 6 has an outer diameter slightly smaller than the inner diameter of the syringe 4 and is inserted from the open end 7 of the syringe 4. When the tightening nut 8 is tightened, the inner diameter of the body 1 is decreased, the syringe 4 is gripped, and the inner diameter of the syringe 4 is also decreased to form the seal portion 9. The tightening force of the tightening nut 8 is adjusted so that the piston 6 can slide left and right. The tightening nut 8 is loosened, the piston 6 is pulled out, and the syringe 4 is filled with liquid with a spoid or the like. The piston 6 is inserted a little again and the tightening nut 8 is tightened. When the piston 6 is pushed a little into the syringe 4, a liquid having a volume of the cross-sectional area of the piston 6 × the amount of pushing is discharged from the nozzle 5. For example, when the piston diameter is 0.3 mm and the pushing amount is 0.01 mm, a liquid of only 0.7 nanoliter can be discharged.

市販品のチュウブ、金属丸棒において極細のもの、例えばチュウブ内径０．２ミリ、金属丸棒０．１ミリを使用して押し込み量０．０１ミリとすると８０ピコリットルの微量吐出が可能となる。微量吐出には極細径のノズルを必要とするがシリンジ４と一体で成形しているので気泡残留が起き難く高粘度液にも適応。シリンジ４はやや軟質の材質のものとして、締め付けナットの調整で内外径増減を可能にしている。A commercially available tube or metal round bar with a very fine diameter, for example, 0.2 mm of tube inner diameter and 0.1 mm of metal round bar, with a push-in amount of 0.01 mm, enables a small amount of 80 picoliters to be discharged. . Although a very small nozzle is required for a small amount of discharge, it is formed integrally with the syringe 4 so that bubbles do not easily remain and is suitable for high viscosity liquids. The syringe 4 is made of a slightly soft material, and the inner and outer diameters can be increased and decreased by adjusting the tightening nut.

利点advantage

▲１▼ ガラス管の内径加工のような精密加工を必要としない。
▲２▼ シール部の構造が簡単で、耐圧力の調整が簡単に行える。
▲３▼ シリンジ４をＰＦＡチュウブ、ピストン６は金属丸棒をＰＦＡ被覆したものにすると接液部はすべてＰＦＡ材となり耐薬品性の優れたものになる。
▲４▼ シリンジ４、ノズル５は一体成形でき、気泡が残らず、液の滞留が無く、流れがスムースである。
▲５▼ ピストン６の押し込み中はシール部より離れていく方向になるので、固体粒子がかじらない。銀ペースト等の微量吐出が可能になる。
▲６▼ ノズル５部で圧着封止し液をいれて密閉して液体容器とできる。
▲７▼ ピストン６を抜いて、シリンジ４をピストン６と同径の他の直管ノズルの先端に装着し極細ノズルとして使用できる。
▲８▼ ピストン６の代わりに、圧力、流速、流量、導入時間を制御したエア、ガスを導入するとシリンジ４内の液を吐出するより安価な装置が可能となる。
▲９▼ ノズル５は加熱成形等で極細ノズルに加工できる。
▲１０▼ シリンジ４の内径、ピストン６の外径共に極細径で構成できるので微量吐出が容易に得られる。(1) There is no need for precision processing such as glass tube inner diameter processing.
(2) The structure of the seal part is simple and the pressure resistance can be easily adjusted.
(3) If the syringe 4 is made of a PFA tube and the piston 6 is made of a metal round bar coated with PFA, all the wetted parts become PFA materials and have excellent chemical resistance.
(4) The syringe 4 and the nozzle 5 can be integrally formed, no bubbles remain, no liquid stays, and the flow is smooth.
(5) Since the piston 6 is pushed away from the seal portion, solid particles are not gnawed. A small amount of silver paste can be discharged.
{Circle around (6)} A liquid container can be formed by pressure-sealing with 5 parts of the nozzle and sealing with liquid.
(7) The piston 6 can be removed, and the syringe 4 can be attached to the tip of another straight pipe nozzle having the same diameter as the piston 6 and used as an ultrafine nozzle.
(8) Introducing air or gas with controlled pressure, flow velocity, flow rate, and introduction time instead of the piston 6 enables a cheaper device that discharges the liquid in the syringe 4.
(9) The nozzle 5 can be processed into an ultrafine nozzle by heat molding or the like.
{Circle around (10)} Since the inner diameter of the syringe 4 and the outer diameter of the piston 6 can be configured with extremely small diameters, a small amount of discharge can be easily obtained.

ボデイ１１は一端に締め付けナット１８を持つ内径減少金具１２を形成し、貫通する穴１３にシリンジ１４を挿入保持している。シリンジ１４はＰＦＡ等透明樹脂材のチューブ状とし一端は細径にしてノズル１５を形成する。シリンジの開放端１７にピストン挿入穴２０のあるスリーブ１９を挿入する。丸棒状のピストン１６は挿入穴２０の内径より若干細い外径とする。締め付けナット１８を締めるとボデイ１１の内径を減少し、シリンジ１４を掴着すると共に、スリーブ１９の内径も減少さしシール部２１を形成する。ピストン１６が左右に摺動できる程度に締め付けナット１８の締め付け力を加減する。The body 11 is formed with an inner diameter-reducing metal fitting 12 having a tightening nut 18 at one end, and a syringe 14 is inserted and held in a through-hole 13. The syringe 14 has a tube shape made of a transparent resin material such as PFA and has one end with a small diameter to form the nozzle 15. A sleeve 19 having a piston insertion hole 20 is inserted into the open end 17 of the syringe. The round bar-shaped piston 16 has an outer diameter slightly smaller than the inner diameter of the insertion hole 20. When the tightening nut 18 is tightened, the inner diameter of the body 11 is decreased, the syringe 14 is gripped, and the inner diameter of the sleeve 19 is also decreased to form the seal portion 21. The tightening force of the tightening nut 18 is adjusted to such an extent that the piston 16 can slide left and right.

実施例１の場合シリンジ４とピストン６との直径方向スキマが僅かなので沈殿、分離する液のとき振っても混合しにくいが、実施例２の場合スキマが大で混合が容易になる。In the case of Example 1, since there is little radial clearance between the syringe 4 and the piston 6, mixing is difficult even if shaken when the liquid to be precipitated and separated, but in the case of Example 2, the clearance is large and mixing is easy.

ボデイ３０は両端に締め付けナット３３，３４を設け、内径収縮用のコーン３１，３２を挿入している。シリンジ３５はボデイ３０の左側に挿入し、スリーブ３６は右側に挿入する。ピストン３７はスリーブ３６の内径より若干細くしている。シリンジ３５は締め付けナット３４でボデイ３０に固着し、ピストン３７は左右に摺動できるように締め付けナット３３の締め加減を調節する。The body 30 is provided with fastening nuts 33 and 34 at both ends, and inserts cones 31 and 32 for contracting the inner diameter. The syringe 35 is inserted on the left side of the body 30 and the sleeve 36 is inserted on the right side. The piston 37 is slightly thinner than the inner diameter of the sleeve 36. The syringe 35 is fixed to the body 30 with a tightening nut 34, and the tightening of the tightening nut 33 is adjusted so that the piston 37 can slide left and right.

実施例３はシリンジ３５がシール部のスリーブ３６と分離しており、シール部のみの交換が可能となる。ボデイ３０の胴部にタンク管路、バルブ管路等の設置が容易となる。
スリーブ３６に換わりエア配管を挿入し、圧力、流速、流量、導入時間を制御したエア、ガスを導入するとシリンジ３５内の液を吐出できる。
締め付けナット３４側でもピストン３７を支えると、ピストン３７は２点で支えられるので、ふらつきが抑えられ高精度の移動が確保できる。In the third embodiment, the syringe 35 is separated from the sleeve 36 of the seal portion, and only the seal portion can be replaced. A tank line, a valve line, etc. can be easily installed on the body of the body 30.
The air in the syringe 35 can be discharged by inserting air piping instead of the sleeve 36 and introducing air or gas with controlled pressure, flow velocity, flow rate, and introduction time.
When the piston 37 is supported also on the tightening nut 34 side, the piston 37 is supported at two points, so that the wobbling is suppressed and a highly accurate movement can be secured.

実施例１の流体微量吐出シリンジの断面図  Sectional drawing of fluid trace discharge syringe of Example 1 実施例２の流体微量吐出シリンジの断面図  Sectional drawing of fluid trace discharge syringe of Example 2 実施例３の流体微量吐出シリンジの断面図  Sectional drawing of the fluid trace discharge syringe of Example 3

Claims (1)

フッソ樹脂等のチュウブの一端を細く絞りノズルとし、他端外周にチュウブの外径減少金具を設け、チュウブ内径より若干小径の丸棒状のピストンを挿入し、外径減少金具を調整してチュウブ外内径を減少さしピストンにチュウブを密接さす構造のシリンジ。One end of the tube, such as fluorine resin, is made into a narrow nozzle, a tube outer diameter reduction fitting is provided on the outer circumference of the other end, a round bar-shaped piston slightly smaller than the inner diameter of the tube is inserted, and the outer diameter reduction fitting is adjusted to adjust the outer diameter of the tube. A syringe with a structure that reduces the inner diameter and closes the tube to the piston.
JP2005381063A 2005-12-16 2005-12-16 Syringe for discharging trace amount of fluid Pending JP2007160296A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102798426A (en) * 2012-07-25 2012-11-28 吴成芳 Adjustable measuring spoon for liquid mediums
CN107250736A (en) * 2014-11-10 2017-10-13 凯米斯彼得技术股份公司 metering device

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102798426A (en) * 2012-07-25 2012-11-28 吴成芳 Adjustable measuring spoon for liquid mediums
CN107250736A (en) * 2014-11-10 2017-10-13 凯米斯彼得技术股份公司 metering device
US10987666B2 (en) 2014-11-10 2021-04-27 Chemspeed Technologies Ag Metering apparatus

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