JP2007008893A - 抗真菌医薬組成物 - Google Patents
抗真菌医薬組成物 Download PDFInfo
- Publication number
- JP2007008893A JP2007008893A JP2005193935A JP2005193935A JP2007008893A JP 2007008893 A JP2007008893 A JP 2007008893A JP 2005193935 A JP2005193935 A JP 2005193935A JP 2005193935 A JP2005193935 A JP 2005193935A JP 2007008893 A JP2007008893 A JP 2007008893A
- Authority
- JP
- Japan
- Prior art keywords
- antifungal
- pharmaceutical composition
- component
- terbinafine
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Landscapes
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Abstract
【解決手段】 (a)テルビナフィン及び/又はその塩と共に、(b)カンフル及び/又はクロロブタノールを配合して、抗真菌医薬組成物を調製する。
【選択図】なし
Description
項1. (a)テルビナフィン及び/又はその塩、及び(b)カンフル及び/又はクロロブタノールを含有することを特徴とする、抗真菌医薬組成物。
項2. 抗真菌医薬組成物中に、(a)成分が0.2〜1.5重量%、(b)成分が0.01〜10重量%の割合で含有する、項1に記載の抗真菌医薬組成物。
項3. 更に、(c)抗ヒスタミン剤、局所麻酔剤、テルペノイド、及びクロタミトンよりなる群から選択される少なくとも1種を含有する、項1又は2に記載の抗真菌医薬組成物。
項4. テルビナフィン及び/又はその塩を含有する抗真菌医薬組成物の抗真菌作用の増強方法であって、(a)テルビナフィン及び/又はその塩を含有する抗真菌医薬組成物に、(b)カンフル及び/又はクロロブタノールを添加することを特徴とする、増強方法。
項5. (b)成分添加後の抗真菌医薬組成物において、(b)成分の濃度が0.01〜10重量%である、項4に記載の増強方法。
項6. (b)成分添加後の抗真菌医薬組成物において、(a)成分の濃度が0.2〜1.5重量%である、項4に記載の増強方法。
項7. (b)成分添加後の抗真菌医薬組成物において、(a)成分の濃度が0.2〜1.5重量%であり、(b)成分の濃度が0.01〜10重量%である、項4に記載の増強方法。
項8. 抗真菌医薬組成物中の(a)成分の総量1重量部に対して、(b)成分を0.01〜10重量部の割合で添加する、項4乃至7のいずれかに記載の増強方法。
項9. 抗真菌作用の増強対象となる抗真菌医薬組成物が、更に(c)抗ヒスタミン剤、局所麻酔剤、テルペノイド、及びクロタミトンよりなる群から選択される少なくとも1種を含有するものである、項4乃至8のいずれかに記載の増強方法。
1.抗真菌医薬組成物
本発明の抗真菌医薬組成物は、(a)成分として、テルビナフィン及び/又はその塩を含有する。テルビナフィンは、アリルアミン系抗菌剤として公知の化合物である。また、本発明に使用されるテルビナフィンの塩としては、医薬上、薬理学的に又は生理学的に許容されることを限度として、特に制限されるものではない。テルビナフィンの塩の具体例としては、マレイン酸塩、フマル酸塩、酢酸塩等の有機酸塩;塩酸塩、硝酸塩、リン酸塩等の無機酸塩が例示される。(a)成分として、好ましくは、テルビナフィンの塩酸塩(塩酸テルビナフィン)が挙げられる。
殺菌成分:アクリノール、アルキルポリアミノエチルグリシン、イソプロピルメチルフェノール、セチルピリジニウム、デカリニウム、ベルベリン、ベンザルコニウム、クロルヘキシジン、セトリミド、レゾルシン、ベンゼトニウム、ヒノキチオール、及びこれらの塩類(例えば塩化セチルピリジニウム、塩化デカリニウム、塩化ベルベリン、塩化ベンザルコニウム、塩酸クロルヘキシジン、グルコン酸クロルヘキシジン、塩化デカリニウム、安息香酸ベルベリン、塩化ベンゼトニウムなど)など。
ビタミン類:ビタミンA、ビタミンB、ビタミンC、ビタミンE、それらの誘導体、及びそれらの塩類(例えば酢酸トコフェロール、フラビンアデニンジヌクレオチドナトリウム、塩酸ピリドキシン、酢酸レチノール、パルミチン酸レチノール、アスコルビン酸ナトリウムなど)など。
鎮痛成分:サリチル酸、その誘導体、及び塩類(サリチル酸メチルなど)など。
収斂保護成分:酸化亜鉛、タンニン酸、クロルヒドロキシアルミニウムなど。
充血除去成分:エフェドリン、テトラヒドロゾリン、ナファゾリン、フェニレフリン、それらの誘導体、及びそれらの塩類(例えば塩酸エフェドリン、塩酸テトラヒドロゾリン、塩酸ナファゾリン、塩酸フェニレフリン、塩酸メチルエフェドリンなど)など。
生薬成分:シコン、ハマメリス、タイサン、トウキ、セイヨウトチノキ種子及びこれらの粉末、エキスなど。
基材又は担体成分:水、その他水性溶媒、カルボキシメチルスターチナトリウム、結晶セルロース、ステアリン酸マグネシウム、セルロース、乳糖、ハードファット、オクチルドデカノール、グリセリン、軽質流動パラフィン、ゲル化炭化水素、ショ糖脂肪酸エステル、酒石酸、シリコン樹脂、ジエタノールアミン、自己乳化型モノステアリン酸グリセリン、ジメチルポリシロキサン、スクワラン、ステアリルアルコール、ステアリン酸、ステアリン酸グリセリン、セタノール、セトステアリルアルコール,D-ソルビトール、炭酸水素ナトリウム、中鎖脂肪酸トリグリセリド、トウモロコシデンプン、パラフィン、パルミチン酸、パルミチン酸セチル、プロピレングリコール、プロピレングリコール脂肪酸エステル、1,3ブチレングリコール、ポリオキシエチレンセチルエーテル、ミリスチン酸イソプロピル、ミリスチン酸オクチルドデシル、ミリスチン酸セチル、モノステアリン酸グリセリン、ワセリンなど。
pH調整剤:塩酸、硫酸、リン酸、ポリリン酸、ホウ酸等の無機酸;乳酸、酢酸、クエン酸、酒石酸、リンゴ酸、コハク酸、シュウ酸、グルコン酸、フマル酸、プロピオン酸、酢酸、アスパラギン酸、イプシロン−アミノカプロン酸、グルタミン酸、アミノエチルスルホン酸等の有機酸;炭酸水素ナトリウム、炭酸ナトリウム、水酸化カリウム、水酸化ナトリウム、水酸化カルシウム、水酸化マグネシウム等の無機塩基;モノエタノールアミン、トリエタノールアミン、ジイソプロパノールアミン、トリイソプロパノールアミン、リジン等の有機塩基など。
緩衝剤:ホウ酸緩衝剤、リン酸緩衝剤、炭酸緩衝剤、クエン酸緩衝剤、酢酸緩衝剤、イプシロン−アミノカプロン酸、アスパラギン酸、アスパラギン酸塩など。
安定化剤:ジブチルヒドロキシトルエン、エデト酸ナトリウム、亜硫酸ナトリウム、乾燥亜硫酸ナトリウムなど。
増粘剤:キサンタンガム、ヒドロキシプロピルメチルセルロース、ヒドロキシプロピルセルロース、マクロゴール400、マクロゴール1500、マクロゴール4000、カルボキシビニルポリマーなど。
界面活性剤:ポリソルベート60、ステアリン酸ソルビタン、モノステアリン酸ソルビタン、ステアリン酸ポリオキシル、ポリオキシエチレン硬化ヒマシ油60、ポリソルベート80など。
防腐剤:ブチルパラベン、メチルパラベン、プロピルパラベン、エチルパラベン、安息香酸ナトリウム、ベンジルアルコールなど。
前述するように、(a)テルビナフィン及び/又はその塩と、(b)カンフル及び/又はクロロブタノールの中の1種又は2種以上とを組み合わせて配合することにより、テルビナフィン及び/又はその塩の抗真菌作用を増強することができる。従って、本発明は、他の観点から、(a)テルビナフィン及び/又はその塩を含有する抗真菌医薬組成物に、(b)カンフル及び/又はクロロブタノールを添加することを特徴とする、(a)成分含有抗真菌医薬組成物の抗真菌作用の増強方法を提供する。当該方法において、使用される(a)成分、(b)成分、及びその他の配合成分の種類や配合割合、抗真菌医薬組成物の形態や用途等については、前記「1.抗真菌医薬組成物」の場合と同様である。
試験例1 抗真菌効果の評価試験
表1に示す組成の試験液(実施例1−3及び比較例1−5)を調製し、それぞれの試験液について、抗真菌作用の評価を以下の方法に従って行った。まず、ミューラーヒントン寒天培地(栄研化学製)を、直径15cmのシャーレに基層として正確に50mL添加(厚さ約2.8mm程度)し固めた。次に、Trichophytonrubrum(ATCC 28188)を最終濃度が1×106cfu/mlとなるように接種したミューラーヒントン寒天培地を積層として正確に30mL(層の厚さ約1.7 mm)添加して、Trichophyton rubrumが混釈された平板寒天培地を作製した。次いで、各試験液40μlをしみ込ませた直径8mmのペーパーディスクを上記平板寒天培地上において、33℃で7日間培養を行った。培養後、平板寒天培地上に形成された阻止円の大きさ(直径)を測定した。各試験液を使用した場合の阻止円の大きさから下記式に従って、抗真菌作用の相対活性値を算出した。
常法により、以下の表2に記載の処方のクリーム剤を調製した。
常法により、以下の表3に記載の処方のクリーム剤を調製した。
常法により、実施例17−19に示す組成の液剤を調製した。また、実施例20−22に示す組成の液剤を調製し、これを薬液として適宜ガスとともにエアゾール製剤用の容器に充填し、エアゾール製剤を調製した。
常法により、実施例23−25に示す組成の液剤を調製した。また、実施例26−28に示す組成の液剤を調製し、これを薬液として適宜ガスとともにエアゾール製剤用の容器に充填し、エアゾール製剤を調製した。
Claims (4)
- (a)テルビナフィン及び/又はその塩、及び
(b)カンフル及び/又はクロロブタノール
を含有することを特徴とする、抗真菌医薬組成物。 - 抗真菌医薬組成物中に、(a)成分を0.2〜1.5重量%、(b)成分を0.01〜10重量%の割合で含有する、請求項1に記載の抗真菌医薬組成物。
- 更に、(c)抗ヒスタミン剤、局所麻酔剤、テルペノイド、及びクロタミトンよりなる群から選択される少なくとも1種を含有する、請求項1又は2に記載の抗真菌医薬組成物。
- テルビナフィン及び/又はその塩を含有する抗真菌医薬組成物の抗真菌作用の増強方法であって、(a)テルビナフィン及び/又はその塩を含有する抗真菌医薬組成物に、(b)カンフル及び/又はクロロブタノールを添加することを特徴とする、増強方法。
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Cited By (6)
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JP2009102310A (ja) * | 2007-10-01 | 2009-05-14 | Taisho Pharmaceutical Co Ltd | 皮膚外用クリーム剤 |
JP2011207835A (ja) * | 2010-03-30 | 2011-10-20 | Kobayashi Pharmaceutical Co Ltd | 抗真菌組成物 |
JP2012126733A (ja) * | 2012-03-15 | 2012-07-05 | Ikeda Mohando:Kk | 外用医薬組成物 |
JP2012158567A (ja) * | 2011-02-02 | 2012-08-23 | Rohto Pharmaceutical Co Ltd | 皮膚外用組成物 |
JP2014065704A (ja) * | 2012-08-24 | 2014-04-17 | Rohto Pharmaceut Co Ltd | 皮膚外用組成物 |
CN102727494B (zh) * | 2009-10-31 | 2016-08-17 | 鲁南制药集团股份有限公司 | 一种治疗皮肤真菌感染的外用药物组合物 |
Citations (1)
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JP2003055205A (ja) * | 2001-08-09 | 2003-02-26 | Taisho Pharmaceut Co Ltd | 抗真菌病組成物 |
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JP2003055205A (ja) * | 2001-08-09 | 2003-02-26 | Taisho Pharmaceut Co Ltd | 抗真菌病組成物 |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009102310A (ja) * | 2007-10-01 | 2009-05-14 | Taisho Pharmaceutical Co Ltd | 皮膚外用クリーム剤 |
CN102727494B (zh) * | 2009-10-31 | 2016-08-17 | 鲁南制药集团股份有限公司 | 一种治疗皮肤真菌感染的外用药物组合物 |
JP2011207835A (ja) * | 2010-03-30 | 2011-10-20 | Kobayashi Pharmaceutical Co Ltd | 抗真菌組成物 |
JP2012158567A (ja) * | 2011-02-02 | 2012-08-23 | Rohto Pharmaceutical Co Ltd | 皮膚外用組成物 |
JP2012126733A (ja) * | 2012-03-15 | 2012-07-05 | Ikeda Mohando:Kk | 外用医薬組成物 |
JP2014065704A (ja) * | 2012-08-24 | 2014-04-17 | Rohto Pharmaceut Co Ltd | 皮膚外用組成物 |
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