JP2006311917A - Low-frequency electric stimulation device - Google Patents

Low-frequency electric stimulation device Download PDF

Info

Publication number
JP2006311917A
JP2006311917A JP2005135572A JP2005135572A JP2006311917A JP 2006311917 A JP2006311917 A JP 2006311917A JP 2005135572 A JP2005135572 A JP 2005135572A JP 2005135572 A JP2005135572 A JP 2005135572A JP 2006311917 A JP2006311917 A JP 2006311917A
Authority
JP
Japan
Prior art keywords
low
frequency
energizing
skin
conductor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2005135572A
Other languages
Japanese (ja)
Inventor
Shozo Terauchi
尚三 寺内
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP2005135572A priority Critical patent/JP2006311917A/en
Publication of JP2006311917A publication Critical patent/JP2006311917A/en
Pending legal-status Critical Current

Links

Images

Landscapes

  • Electrotherapy Devices (AREA)

Abstract

<P>PROBLEM TO BE SOLVED: To provide a low-frequency electric stimulation device capable of effectively applying low-frequency electric stimulation from the surface of the skin outside the nasal cavities or the mucosal wall inside the nasal cavities. <P>SOLUTION: The low-frequency electric stimulation device comprises a low-frequency transmitter 1, a pair of skin energizing conductors 2A and 2B, and a pair of mucosa energizing conductors 3A and 3B to be inserted into left and right nasal cavities. The low-frequency transmitter 1 has a skin energizing oscillator 1A and a mucosa energizing oscillator 1B whose output voltage and frequency can be changed. Each mucosa energizing conductors 3A or 3B has a rod-like conductor 4 and a water-retaining layer 5 detachably attached to the outer periphery of the rod-like conductor 4. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

本発明は、鼻腔内粘膜を含む鼻の周辺に低周波電気刺激を付与し、種々の鼻粘膜症状を軽減、解消すると共に鼻粘膜を強化して発症を予防するのに適した低周波電気刺激装置に関する。   The present invention provides low frequency electrical stimulation to the periphery of the nose including the intranasal mucosa to reduce and eliminate various nasal mucosal symptoms and to strengthen the nasal mucosa to prevent onset. Relates to the device.

従来、肩、腕、脚などの皮膚表面から低周波電気を当てて、患部に電気的刺激を付与する低周波電気治療が行われており、これによって血流を促進し、筋肉のこり等が軽減、解消される。
この低周波電気治療に際して、複数の部位を同時に電気刺激することができる低周波電気治療装置も知られている。この種の低周波電気治療装置は、低周波発振部に正極、負極を一対とする、複数対の導子を接続し、一対の導子を一組として各部位に貼着することで、複数の部位に低周波電気刺激を同時に付与するようにしたものである。
Conventionally, low-frequency electrical treatment that applies electrical stimulation to the affected area by applying low-frequency electricity from the skin surface of the shoulder, arm, leg, etc. has been performed, thereby promoting blood flow and reducing muscle stiffness etc. To be eliminated.
In this low frequency electrotherapy, a low frequency electrotherapy apparatus capable of simultaneously stimulating a plurality of parts is also known. This type of low-frequency electrotherapy device connects a plurality of pairs of conductors with a pair of positive and negative electrodes to the low-frequency oscillator, and a plurality of pairs of conductors are attached to each site as a pair. The low-frequency electrical stimulation is simultaneously applied to the part.

近年、花粉症、アレルギー性鼻炎などが活発化しており、その際、種々の鼻粘膜症状が発現する。本発明者は、これらの症状を軽減、解消するため、鼻腔内の粘膜壁を通して電気治療することを試みたが、従来の低周波電気治療装置は、その通電部位が皮膚を想定したものであるため、導子形状を鼻腔に挿入可能な形状としても、導子の表面が鼻腔内粘膜に一様に接触しないため、十分な治療効果が得られず、また導子が局部的に粘膜壁に接触するため、安全性にも問題があった。   In recent years, hay fever, allergic rhinitis and the like have become active, and various nasal mucosal symptoms appear at that time. In order to reduce or eliminate these symptoms, the present inventor tried to perform electrical treatment through the mucosal wall in the nasal cavity, but the conventional low-frequency electrotherapy apparatus assumes that the energized site is the skin. For this reason, even if the shape of the lead is made to be insertable into the nasal cavity, the surface of the lead is not uniformly in contact with the mucous membrane in the nasal cavity, so that a sufficient therapeutic effect cannot be obtained, and the lead is locally applied to the mucosal wall. There was a problem with safety because of contact.

また、本発明者の研究により、単に鼻腔内粘膜壁に電気刺激を施すだけでは、十分な治療効果が得られず、鼻腔の外側の皮膚表面からも電気刺激を付与することが有効であることが分かったが、従来の低周波電気治療装置は、電気刺激を付与する部位として、すべて皮膚を想定しているため、出力電圧が可変とされているにすぎず、皮膚と共に鼻腔内粘膜へ有効な低周波電気刺激を付与することができなかった。すなわち、鼻腔内粘膜壁へ低周波電気刺激を付与するとなると、皮膚を通して低周波電気刺激を付与する場合に比して通電条件が全く異なるため、従来の低周波電気治療装置では、鼻腔内粘膜壁への低周波電気刺激と、鼻腔外の皮膚表面からの低周波電気刺激とを同時に最適条件に調整することができなかった。   In addition, according to the study of the present inventor, merely applying electrical stimulation to the mucosal wall in the nasal cavity does not provide a sufficient therapeutic effect, and it is effective to apply electrical stimulation from the skin surface outside the nasal cavity. However, since the conventional low-frequency electrotherapy device assumes the skin as the site for applying electrical stimulation, the output voltage is only variable, and it is effective with the skin to the intranasal mucosa. A low frequency electrical stimulation could not be applied. That is, when applying low-frequency electrical stimulation to the intranasal mucosal wall, the energization conditions are completely different compared to applying low-frequency electrical stimulation through the skin. It was impossible to adjust the low-frequency electrical stimulation to the skin and the low-frequency electrical stimulation from the skin surface outside the nasal cavity to the optimum conditions at the same time.

本発明はかかる問題に鑑みなされたもので、鼻腔外の皮膚表面及び鼻腔内の粘膜壁から効果的に低周波電気刺激を付与することができる低周波電気刺激装置を提供することを目的とする。   The present invention has been made in view of such problems, and an object thereof is to provide a low-frequency electrical stimulation device that can effectively apply low-frequency electrical stimulation from the skin surface outside the nasal cavity and the mucosal wall in the nasal cavity. .

本発明の低周波電気刺激装置は、低周波発信装置と、一対の皮膚通電用導子と、左右の鼻腔内に挿入される一対の粘膜通電用導子とを備える。前記低周波発信装置は、前記皮膚通電用導子が接続される皮膚通電用発振部と、前記粘膜通電用導子が接続される粘膜通電用発振部とを有し、前記皮膚通電用発振部と粘膜通電用発振部とはそれぞれ出力電圧および周波数が可変とされる。   The low-frequency electrical stimulation device of the present invention includes a low-frequency transmission device, a pair of skin conduction conductors, and a pair of mucosal conduction conductors inserted into the left and right nasal cavities. The low-frequency transmission device includes an oscillating portion for energizing the skin to which the conductor for energizing the skin is connected, and an oscillating portion for energizing the mucosa to which the conductor for energizing the mucosa is connected. And the mucosal energization oscillating unit are variable in output voltage and frequency.

本発明の低周波電気刺激装置によれば、低周波発信装置は皮膚通電用導子が接続される皮膚通電用発振部と、粘膜通電用導子が接続される粘膜通電用発振部とを有し、前記皮膚通電用発振部と粘膜通電用発振部とはそれぞれ出力電圧および周波数が可変とされるので、皮膚通電と粘膜通電とをそれぞれ電圧のみならず、周波数も制御することができ、各部位に対して最適な通電条件にて低周波電気刺激を施すことができる。   According to the low-frequency electrical stimulation device of the present invention, the low-frequency transmission device has an oscillating portion for energizing the skin to which the conducting conductor for skin is connected and an oscillating portion for energizing the mucosa to which the conducting agent for mucosa is connected. In addition, since the skin electrification oscillation unit and the mucous membrane electrification oscillation unit each have variable output voltage and frequency, the skin electrification and mucosal electrification can control not only the voltage but also the frequency, Low-frequency electrical stimulation can be applied to the region under optimum energization conditions.

また、前記粘膜通電用導子は、棒状導体と、前記棒状導体の外周部に被覆される保水層とを設け、前記保水層を繊維、織布あるいは軟質多孔質材によって形成することが好ましい。
この粘膜通電用導子によると、保水層に水あるいは生理食塩水を含ませて導子を鼻腔内に挿入することによって、鼻腔内粘膜壁への導子の局部的な接触を防止しつつ、鼻腔内の複雑な凹凸状の粘膜壁の全体に渡って一様に通電することができ、局部接触による粘膜壁の損傷を防止しつつ、安全かつ効果的に低周波電気刺激を施すことができる。
In addition, it is preferable that the conductive mucosal conductor is provided with a rod-shaped conductor and a water retention layer coated on the outer periphery of the rod-shaped conductor, and the water retention layer is formed of a fiber, a woven fabric, or a soft porous material.
According to this mucosal energizer, by inserting water or physiological saline in the water retaining layer and inserting the lead into the nasal cavity, the local contact of the conductor to the intranasal mucosal wall is prevented, It can be energized uniformly over the entire complex rugged mucosal wall in the nasal cavity, and can safely and effectively apply low-frequency electrical stimulation while preventing damage to the mucosal wall due to local contact. .

また、前記粘膜通電用導子の棒状導体は、少なくともその外周部を耐食性材料によって形成することが好ましい。これによって、保水層に生理食塩水を保持させる場合においても、前記棒状導体が腐食されにくくなり、耐久性が向上する。   Moreover, it is preferable that at least the outer peripheral portion of the rod-shaped conductor of the mucosal energizing conductor is formed of a corrosion resistant material. Thereby, even when the physiological saline is held in the water retention layer, the rod-shaped conductor is hardly corroded, and the durability is improved.

本発明の低周波電気刺激装置によれば、低周波発信装置に電圧及び周波数がそれぞれ制御可能な皮膚通電用発振部と粘膜通電用発振部とを有するので、皮膚通電と粘膜通電とをそれぞれ電圧のみならず、周波数も制御することができ、各部位に対して最適な通電条件にて低周波電気刺激を施すことができる。また、粘膜通電用導子に保水層を設けることで、この保水層に水あるいは生理食塩水を含ませて導子を鼻腔内に挿入することができ、これにより導子の局部的な接触を防止しつつ、鼻腔内の複雑な凹凸状の粘膜壁に一様に通電することができ、局部接触による粘膜壁の損傷を防止しつつ、安全かつ効果的に低周波電気刺激を施すことができる。   According to the low-frequency electrical stimulation device of the present invention, the low-frequency transmission device includes the oscillating portion for energizing the skin and the oscillating portion for energizing the mucosa, each of which can control the voltage and the frequency. Not only can the frequency be controlled, but low frequency electrical stimulation can be applied to each part under optimum energization conditions. In addition, by providing a water retention layer on the conductive mucosal conductor, the water retention layer can be filled with water or physiological saline so that the conductor can be inserted into the nasal cavity, thereby preventing localized contact of the conductor. It is possible to uniformly energize the complex rugged mucosal wall in the nasal cavity while preventing it, and to safely and effectively apply low-frequency electrical stimulation while preventing damage to the mucosal wall due to local contact .

以下、本発明の低周波電気刺激装置の実施形態を図面を参照して説明する。
図1に示すように、実施形態の低周波電気刺激装置は、低周波発信装置1と、正負極一対の皮膚通電用導子2A,2Bと、左右の鼻腔内に挿入される正負極一対の粘膜通電用導子3A,3Bとを備える。
Hereinafter, embodiments of the low frequency electrical stimulation device of the present invention will be described with reference to the drawings.
As shown in FIG. 1, the low-frequency electrical stimulation device of the embodiment includes a low-frequency transmission device 1, a pair of positive and negative skin conduction conductors 2 </ b> A and 2 </ b> B, and a pair of positive and negative electrodes inserted into the left and right nasal cavities. And mucosal current conducting conductors 3A and 3B.

前記低周波発信装置1は、前記皮膚通電用導子2A,2Bが接続される皮膚通電用発振部1Aと、前記粘膜通電用導子3A,3Bが接続される粘膜通電用発振部1Bとを有する。各発振部1A,1Bは、それぞれ電源スイッチ8によって出力がオンオフされ、電圧調整器9によって電圧が、周波数調整器10によって周波数が調整される。11は、電圧、周波数を表示する表示部である。出力周波数範囲については、皮膚通電用出力では50〜200Hz程度、粘膜通電用出力では5〜50Hz程度とするのがよい。なお、前記皮膚通電用発振部1Aと粘膜通電用発振部1Bは、各々発振回路を設けてもよいが、基本低周波発振回路を設け、これからの基本低周波を皮膚通電用発振部と粘膜通電用発振部に入力し、各発振部で分周して所望周波数の低周波を得るようにしてもよい。   The low-frequency transmission device 1 includes an oscillating portion 1A for energizing the skin to which the conductors 2A and 2B for energizing the skin are connected, and an oscillating portion 1B for energizing the mucosa and the conductors 3A and 3B for energizing the mucosa. Have. The outputs of the oscillation units 1A and 1B are turned on and off by the power switch 8, the voltage is adjusted by the voltage regulator 9, and the frequency is adjusted by the frequency regulator 10. Reference numeral 11 denotes a display unit that displays voltage and frequency. The output frequency range is preferably about 50 to 200 Hz for skin energization output and about 5 to 50 Hz for mucosa energization output. The skin energization oscillation unit 1A and the mucosa energization oscillation unit 1B may each be provided with an oscillation circuit, but a basic low frequency oscillation circuit is provided, and the basic low frequency from now on is applied to the skin energization oscillation unit and the mucosa energization. A low frequency of a desired frequency may be obtained by inputting to the oscillation unit for frequency division and dividing by each oscillation unit.

前記皮膚通電用導子2A,2Bは、各辺が10〜15mm各程度の平面視方形をしており、その表面には導電性粘着層7が貼着されている。この導電性粘着層7は、使用ごとに交換するようにしてもよい。
一方、前記粘膜通電用導子3A,3Bは、図2に示すように、導電性硬質ゴムで形成された棒状導体4と、前記棒状導体4の外周部に着脱自在に被覆された保水層5と、前記棒状導体4の下端部にプラスチックで形成された円盤状のストッパー6を備える。前記保水層5は、綿花やガーゼなどの親水性繊維やその織布、軟質で空隙率の高い発泡樹脂(スポンジ)などの保水性に優れた多孔質材よって形成されている。前記棒状導体4は、直径2〜5mm程度、長さ10〜20mm程度であり、保水層5の外径は鼻孔に軽く挿入される程度とされる。鼻孔内に導子を挿入する場合は、水、好ましくは生理食塩水をたっぷり含ませる。これによって、鼻腔内の粘膜壁に対する棒状導体4の局部的な接触を防止しつつ、鼻腔内の複雑な凹凸状の粘膜壁に一様に通電することができるようになる。前記保水層5は、衛生上、使用ごとに交換することが好ましい。前記棒状導体4は、導電性硬質ゴムに限らず、生理食塩水を用いた場合でも腐食されにくい導電性材料で形成すればよく、例えばステンレス鋼棒あるいは銅棒を用いることができ、さらに導電性金属棒に導電性かつ耐食性のある金属材、例えばニッケルをめっきしたり、導電性ゴムを被覆するようにしてもよい。
The skin-conducting conductors 2A and 2B have a square shape in a plan view with each side of about 10 to 15 mm, and a conductive adhesive layer 7 is adhered to the surface thereof. You may make it replace | exchange this electroconductive adhesion layer 7 for every use.
On the other hand, as shown in FIG. 2, the mucosal energizing conductors 3A and 3B are composed of a rod-shaped conductor 4 made of conductive hard rubber and a water retaining layer 5 detachably coated on the outer periphery of the rod-shaped conductor 4. And a disc-shaped stopper 6 made of plastic at the lower end of the rod-shaped conductor 4. The water retention layer 5 is formed of a porous material excellent in water retention, such as a hydrophilic fiber such as cotton or gauze, a woven fabric thereof, or a soft foam resin (sponge) having a high porosity. The rod-shaped conductor 4 has a diameter of about 2 to 5 mm and a length of about 10 to 20 mm. The outer diameter of the water retaining layer 5 is such that it can be inserted lightly into the nostril. When the lead is inserted into the nostril, a lot of water, preferably physiological saline, is contained. This makes it possible to uniformly energize the complex uneven mucosal wall in the nasal cavity while preventing local contact of the rod-like conductor 4 with the mucosal wall in the nasal cavity. It is preferable to replace the water-retaining layer 5 every use for hygiene purposes. The rod-shaped conductor 4 is not limited to conductive hard rubber, but may be formed of a conductive material that is not easily corroded even when physiological saline is used. For example, a stainless steel rod or a copper rod can be used. The metal rod may be plated with a conductive and corrosion-resistant metal material, such as nickel, or covered with conductive rubber.

前記低周波電気刺激装置の使用例について図3を参照して説明する。
まず、前記低周波電気刺激装置の皮膚通電用導子2A,2Bを鼻梁(鼻骨)の左右上部の皮膚表面に貼着し、一方、粘膜通電用導子3A,3Bの保水層5に水、好ましくは生理食塩水をたっぷり含ませて鼻腔内に挿入する。
次に、低周波発振装置1の電源を入れ、低周波電気の電圧、周波数を調整しつつ、皮膚通電用発振部1Aおよび粘膜通電用発振部1Bから出力する。長時間、鼻粘膜に電気刺激を付与すると、刺激が強すぎて副作用が生じるおそれがあるので、通常、低周波電気刺激は、一回当たり5〜20分程度に止めることが好ましい。
通電時間を経過した後、電源を切り、皮膚通電用導子2A,2Bを外し、導電性粘着層7を取り替え、また粘膜通電用導子3A,3Bの保水層5を取り替えて、次の使用に備える。
An example of use of the low-frequency electrical stimulation device will be described with reference to FIG.
First, the skin electrification conductors 2A and 2B of the low-frequency electrical stimulation device are attached to the left and right upper skin surfaces of the nasal bridge (nasal bones), while water is applied to the water retaining layer 5 of the mucosal electrification conductors 3A and 3B. Preferably, it is inserted into the nasal cavity with plenty of physiological saline.
Next, the low-frequency oscillation device 1 is turned on, and the voltage and frequency of the low-frequency electricity are adjusted and output from the skin conduction oscillation unit 1A and the mucosal conduction oscillation unit 1B. If electrical stimulation is applied to the nasal mucosa for a long time, the stimulation is too strong and side effects may occur. Therefore, it is usually preferable to stop the low-frequency electrical stimulation for about 5 to 20 minutes per time.
After the energization time has elapsed, the power is turned off, the skin energizing conductors 2A and 2B are removed, the conductive adhesive layer 7 is replaced, and the water retaining layer 5 of the mucosal energizing conductors 3A and 3B is replaced for the next use. Prepare for.

本発明の低周波電気刺激装置は、主に花粉症やアレルギー性鼻炎等の鼻粘膜症状を軽減、解消、改善するために使用されるが、その他、例えば水、タバコ、花粉などに対して鼻粘膜が過剰に反応しないように、予め鼻腔内粘膜を強化し、鼻粘膜症状が発症しないように、あるいは発症しても軽度で済むように予防、強化する用途に使用することもできる。   The low-frequency electrical stimulation device of the present invention is mainly used to reduce, eliminate, and improve nasal mucosal symptoms such as hay fever and allergic rhinitis. It can be used for the purpose of strengthening the intranasal mucosa in advance so that the mucosa does not react excessively, and preventing or strengthening so that the symptoms of the nasal mucosa do not develop or can be mild even if it develops.

実施形態にかかる低周波電気刺激装置の全体構成図である。1 is an overall configuration diagram of a low-frequency electrical stimulation device according to an embodiment. 粘膜通電用導子の拡大断面図である。It is an expanded sectional view of the conducting mucosa. 低周波電気刺激装置の使用状態説明図である。It is use condition explanatory drawing of a low frequency electrical stimulation apparatus.

符号の説明Explanation of symbols

1 低周波発振装置
1A 皮膚通電用発振部
1B 粘膜通電用発振部
2A,2B 皮膚通電用導子
3A,3B 粘膜通電用導子
4 棒状導体
5 保水層
6 ストッパー
DESCRIPTION OF SYMBOLS 1 Low frequency oscillator 1A Oscillating part 1B for skin energization Oscillating parts 2A, 2B for energizing mucosa 3A, 3B Conductor for energizing mucosa 4 Rod-shaped conductor 5 Water retaining layer 6 Stopper

Claims (3)

低周波発信装置と、一対の皮膚通電用導子と、左右の鼻腔内に挿入される一対の粘膜通電用導子とを備え、
前記低周波発信装置は、前記皮膚通電用導子が接続される皮膚通電用発振部と、前記粘膜通電用導子が接続される粘膜通電用発振部とを有し、前記皮膚通電用発振部と粘膜通電用発振部とはそれぞれ出力電圧および周波数が可変とされた、低周波電気刺激装置。
A low-frequency transmission device, a pair of skin-conducting conductors, and a pair of mucosal-conducting conductors inserted into the left and right nasal cavities,
The low-frequency transmission device includes an oscillating portion for energizing the skin to which the conductor for energizing the skin is connected, and an oscillating portion for energizing the mucosa to which the conductor for energizing the mucosa is connected. A low-frequency electrical stimulation device in which the output voltage and the frequency of the oscillation unit for energizing the mucosa are variable.
前記粘膜通電用導子は、棒状導体と、前記棒状導体の外周部に被覆された保水層とを備え、前記保水層は繊維、織布あるいは軟質多孔質材によって形成された、請求項1に記載した低周波電気刺激装置。   2. The mucosal energization conductor includes a rod-shaped conductor and a water retention layer coated on an outer peripheral portion of the rod-shaped conductor, and the water retention layer is formed of a fiber, a woven fabric, or a soft porous material. The described low frequency electrical stimulation device. 前記粘膜通電用導子の棒状導体は、少なくともその外周部が耐食性材料によって形成された請求項2に記載した、低周波電気刺激装置。

The low-frequency electrical stimulation device according to claim 2, wherein at least an outer peripheral portion of the rod-shaped conductor of the mucosal energizing conductor is formed of a corrosion-resistant material.

JP2005135572A 2005-05-09 2005-05-09 Low-frequency electric stimulation device Pending JP2006311917A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2005135572A JP2006311917A (en) 2005-05-09 2005-05-09 Low-frequency electric stimulation device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2005135572A JP2006311917A (en) 2005-05-09 2005-05-09 Low-frequency electric stimulation device

Publications (1)

Publication Number Publication Date
JP2006311917A true JP2006311917A (en) 2006-11-16

Family

ID=37533667

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2005135572A Pending JP2006311917A (en) 2005-05-09 2005-05-09 Low-frequency electric stimulation device

Country Status (1)

Country Link
JP (1) JP2006311917A (en)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016515467A (en) * 2013-04-19 2016-05-30 オキュリーブ, インコーポレイテッド Nasal stimulation device and method
JP2017522127A (en) * 2014-07-25 2017-08-10 オキュリーブ, インコーポレイテッド Stimulation patterns for treating dry eye
JP2017531529A (en) * 2014-10-22 2017-10-26 オキュリーブ, インコーポレイテッド Stimulation apparatus and method for the treatment of dry eye
US10207108B2 (en) 2014-10-22 2019-02-19 Oculeve, Inc. Implantable nasal stimulator systems and methods
US10252048B2 (en) 2016-02-19 2019-04-09 Oculeve, Inc. Nasal stimulation for rhinitis, nasal congestion, and ocular allergies
US10328262B2 (en) 2010-11-16 2019-06-25 The Board Of Trustees Of The Leland Stanford Junior University Stimulation devices and methods
US10426958B2 (en) 2015-12-04 2019-10-01 Oculeve, Inc. Intranasal stimulation for enhanced release of ocular mucins and other tear proteins
US10537469B2 (en) 2013-03-12 2020-01-21 Oculeve, Inc. Implant delivery devices, systems, and methods
US10610095B2 (en) 2016-12-02 2020-04-07 Oculeve, Inc. Apparatus and method for dry eye forecast and treatment recommendation
US10610695B2 (en) 2014-10-22 2020-04-07 Oculeve, Inc. Implantable device for increasing tear production
US10722718B2 (en) 2010-11-16 2020-07-28 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for treatment of dry eye
US10799696B2 (en) 2014-02-25 2020-10-13 Oculeve, Inc. Polymer formulations for nasolacrimal stimulation
US10918864B2 (en) 2016-05-02 2021-02-16 Oculeve, Inc. Intranasal stimulation for treatment of meibomian gland disease and blepharitis

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10328262B2 (en) 2010-11-16 2019-06-25 The Board Of Trustees Of The Leland Stanford Junior University Stimulation devices and methods
US10722718B2 (en) 2010-11-16 2020-07-28 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for treatment of dry eye
US11771908B2 (en) 2010-11-16 2023-10-03 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for treatment of dry eye
US10835748B2 (en) 2010-11-16 2020-11-17 Oculeve, Inc. Stimulation devices and methods
US10537469B2 (en) 2013-03-12 2020-01-21 Oculeve, Inc. Implant delivery devices, systems, and methods
US10155108B2 (en) 2013-04-19 2018-12-18 Oculeve, Inc. Nasal stimulation devices and methods
US10835738B2 (en) 2013-04-19 2020-11-17 Oculeve, Inc. Nasal stimulation devices and methods
US10238861B2 (en) 2013-04-19 2019-03-26 Oculeve, Inc. Nasal stimulation devices and methods for treating dry eye
US10967173B2 (en) 2013-04-19 2021-04-06 Oculeve, Inc. Nasal stimulation devices and methods for treating dry eye
JP2016515467A (en) * 2013-04-19 2016-05-30 オキュリーブ, インコーポレイテッド Nasal stimulation device and method
US10799695B2 (en) 2013-04-19 2020-10-13 Oculeve, Inc. Nasal stimulation devices and methods
US10799696B2 (en) 2014-02-25 2020-10-13 Oculeve, Inc. Polymer formulations for nasolacrimal stimulation
JP2020096842A (en) * 2014-07-25 2020-06-25 オキュリーブ, インコーポレイテッド Stimulation patterns for treating dry eye
JP2017522127A (en) * 2014-07-25 2017-08-10 オキュリーブ, インコーポレイテッド Stimulation patterns for treating dry eye
US10722713B2 (en) 2014-07-25 2020-07-28 Oculeve, Inc. Stimulation patterns for treating dry eye
EP3721938A1 (en) * 2014-10-22 2020-10-14 Oculeve, Inc. Stimulation devices and methods for treating dry eye
US10780273B2 (en) 2014-10-22 2020-09-22 Oculeve, Inc. Stimulation devices and methods for treating dry eye
US10610695B2 (en) 2014-10-22 2020-04-07 Oculeve, Inc. Implantable device for increasing tear production
JP2020189105A (en) * 2014-10-22 2020-11-26 オキュリーブ, インコーポレイテッド Stimulation devices and methods for treating dry eye
US10207108B2 (en) 2014-10-22 2019-02-19 Oculeve, Inc. Implantable nasal stimulator systems and methods
JP2017531529A (en) * 2014-10-22 2017-10-26 オキュリーブ, インコーポレイテッド Stimulation apparatus and method for the treatment of dry eye
US10426958B2 (en) 2015-12-04 2019-10-01 Oculeve, Inc. Intranasal stimulation for enhanced release of ocular mucins and other tear proteins
US10252048B2 (en) 2016-02-19 2019-04-09 Oculeve, Inc. Nasal stimulation for rhinitis, nasal congestion, and ocular allergies
US10940310B2 (en) 2016-02-19 2021-03-09 Oculeve, Inc. Nasal stimulation for rhinitis, nasal congestion, and ocular allergies
US10918864B2 (en) 2016-05-02 2021-02-16 Oculeve, Inc. Intranasal stimulation for treatment of meibomian gland disease and blepharitis
US10610095B2 (en) 2016-12-02 2020-04-07 Oculeve, Inc. Apparatus and method for dry eye forecast and treatment recommendation

Similar Documents

Publication Publication Date Title
JP2006311917A (en) Low-frequency electric stimulation device
JP5794750B2 (en) Tissue treatment bandage
EP2124859B1 (en) Devices, systems and methods for shortening menstrual period duration
US6684107B1 (en) Wrinkle-reducing system
KR101548693B1 (en) Massager device for improving of rhinitis
BRPI0517186B1 (en) DEVICE FOR ELECTRIC INHIBITION OF FACIAL MUSCLES
JP2008054701A (en) Cosmetic apparatus using ultrasonic wave and low frequency pulse
KR20180015998A (en) Low frequency stimulator for underwater healthcare
JP2007037853A (en) Sleep disorder treatment device
KR20100028761A (en) Electrode unit for high frequency treatment apparatus and high frequency treatment apparatus having the same
JP3217111U (en) Electrical stimulator
US9421367B1 (en) Method and apparatus for performing microcurrent electrotherapy
KR20020062110A (en) A Massage-Machine having Both Function of Vibration and Low Frequency
KR100972220B1 (en) Ceramic Cup Pad for Electric Stimulator
RU113662U1 (en) ELECTRODE FOR FEEDING SKIN WITH ELECTRIC CURRENT FOR PHYSIOTHERAPY
ES2278627T3 (en) ELECTRICAL STIMULATION SYSTEM OF THE LYMPHATIC SYSTEM.
JP2003265581A (en) Hammer for electric thermotherapeutic apparatus and electric thermotherapeutic apparatus with the same
JP2007195655A (en) Sphincter strengthening device which can thoroughly apply proper electric stimulation over the whole of sphincter
JP5463511B1 (en) Iontophoretic skin infection treatment device
JP2019004939A (en) Muscle stimulation device
JP6703694B2 (en) Deep muscle stimulator
RU2376958C1 (en) Instrument for physiotherapy
JP2019004938A (en) Electrode used for electrostimulator
JP2001178832A (en) Locally discharging device for high voltage therapeutic tool
KR20230080754A (en) Belt-type high frequency lipolysis machine