JP2006016327A - 乳化型皮膚外用剤 - Google Patents
乳化型皮膚外用剤 Download PDFInfo
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- JP2006016327A JP2006016327A JP2004194603A JP2004194603A JP2006016327A JP 2006016327 A JP2006016327 A JP 2006016327A JP 2004194603 A JP2004194603 A JP 2004194603A JP 2004194603 A JP2004194603 A JP 2004194603A JP 2006016327 A JP2006016327 A JP 2006016327A
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- skin
- ascorbic acid
- alcohol
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- 238000002360 preparation method Methods 0.000 title claims abstract description 34
- 239000000839 emulsion Substances 0.000 title abstract description 11
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 31
- 229960005070 ascorbic acid Drugs 0.000 claims abstract description 18
- -1 sorbitan fatty acid ester Chemical class 0.000 claims abstract description 17
- 239000002211 L-ascorbic acid Substances 0.000 claims abstract description 16
- 235000000069 L-ascorbic acid Nutrition 0.000 claims abstract description 14
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 12
- 239000000194 fatty acid Substances 0.000 claims abstract description 12
- 229930195729 fatty acid Natural products 0.000 claims abstract description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000002562 thickening agent Substances 0.000 claims abstract description 7
- 229930006000 Sucrose Natural products 0.000 claims abstract description 6
- 229920001592 potato starch Polymers 0.000 claims abstract description 6
- 239000005720 sucrose Substances 0.000 claims abstract description 6
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 5
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 5
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 5
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 5
- 239000000230 xanthan gum Substances 0.000 claims abstract description 5
- 229920001285 xanthan gum Polymers 0.000 claims abstract description 5
- 229940082509 xanthan gum Drugs 0.000 claims abstract description 5
- 235000010493 xanthan gum Nutrition 0.000 claims abstract description 5
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 claims description 6
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 claims description 6
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 6
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 6
- 235000019864 coconut oil Nutrition 0.000 claims description 5
- 239000003240 coconut oil Substances 0.000 claims description 5
- 238000004945 emulsification Methods 0.000 claims description 4
- 229960000541 cetyl alcohol Drugs 0.000 claims description 3
- 229960000735 docosanol Drugs 0.000 claims description 3
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 3
- 238000003860 storage Methods 0.000 abstract description 11
- 235000019482 Palm oil Nutrition 0.000 abstract 1
- 239000002540 palm oil Substances 0.000 abstract 1
- 230000002087 whitening effect Effects 0.000 description 14
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 6
- 230000009471 action Effects 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 239000002537 cosmetic Substances 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 238000011084 recovery Methods 0.000 description 5
- 239000002253 acid Substances 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 235000019198 oils Nutrition 0.000 description 4
- 239000008346 aqueous phase Substances 0.000 description 3
- 238000013329 compounding Methods 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 239000003995 emulsifying agent Substances 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 230000000475 sunscreen effect Effects 0.000 description 3
- 239000000516 sunscreening agent Substances 0.000 description 3
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 2
- 208000003351 Melanosis Diseases 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- DBSABEYSGXPBTA-RXSVEWSESA-N (2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;phosphoric acid Chemical compound OP(O)(O)=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O DBSABEYSGXPBTA-RXSVEWSESA-N 0.000 description 1
- CGFPNELNAZZYQL-RXSVEWSESA-N (2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;sulfuric acid Chemical compound OS(O)(=O)=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CGFPNELNAZZYQL-RXSVEWSESA-N 0.000 description 1
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 description 1
- PAFJZWHXMSQJKV-UQZRNVAESA-N (3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol;octadecanoic acid Chemical compound OC[C@@H](O)C1OC[C@H](O)[C@H]1O.OC[C@@H](O)C1OC[C@H](O)[C@H]1O.OC[C@@H](O)C1OC[C@H](O)[C@H]1O.CCCCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O PAFJZWHXMSQJKV-UQZRNVAESA-N 0.000 description 1
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
- QAQJMLQRFWZOBN-UHFFFAOYSA-N 2-(3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl)-2-hydroxyethyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)C1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-UHFFFAOYSA-N 0.000 description 1
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 description 1
- FBFZPSQPKNIVMT-ZAFYKAAXSA-N Ascorbic acid 3-sulfate Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1OS(O)(=O)=O FBFZPSQPKNIVMT-ZAFYKAAXSA-N 0.000 description 1
- 239000004261 Ascorbyl stearate Substances 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- AHMIDUVKSGCHAU-UHFFFAOYSA-N Dopaquinone Natural products OC(=O)C(N)CC1=CC(=O)C(=O)C=C1 AHMIDUVKSGCHAU-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010014970 Ephelides Diseases 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- YYVJAABUJYRQJO-UHFFFAOYSA-N Isomyristic acid Natural products CC(C)CCCCCCCCCCC(O)=O YYVJAABUJYRQJO-UHFFFAOYSA-N 0.000 description 1
- MIJPAVRNWPDMOR-ZAFYKAAXSA-N L-ascorbic acid 2-phosphate Chemical compound OC[C@H](O)[C@H]1OC(=O)C(OP(O)(O)=O)=C1O MIJPAVRNWPDMOR-ZAFYKAAXSA-N 0.000 description 1
- XDBMXUKHMOFBPJ-ZAFYKAAXSA-N L-ascorbic acid 2-sulfate Chemical compound OC[C@H](O)[C@H]1OC(=O)C(OS(O)(=O)=O)=C1O XDBMXUKHMOFBPJ-ZAFYKAAXSA-N 0.000 description 1
- 150000000996 L-ascorbic acids Chemical class 0.000 description 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 1
- 235000000072 L-ascorbyl-6-palmitate Nutrition 0.000 description 1
- AHMIDUVKSGCHAU-LURJTMIESA-N L-dopaquinone Chemical compound [O-]C(=O)[C@@H]([NH3+])CC1=CC(=O)C(=O)C=C1 AHMIDUVKSGCHAU-LURJTMIESA-N 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 206010064127 Solar lentigo Diseases 0.000 description 1
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- NCHJGQKLPRTMAO-XWVZOOPGSA-N [(2R)-2-[(2R,3R,4S)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NCHJGQKLPRTMAO-XWVZOOPGSA-N 0.000 description 1
- AQKOHYMKBUOXEB-RYNSOKOISA-N [(2R)-2-[(2R,3R,4S)-4-hydroxy-3-(16-methylheptadecanoyloxy)oxolan-2-yl]-2-(16-methylheptadecanoyloxy)ethyl] 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCCCCCCCC(C)C)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCCCCCCCCCC(C)C AQKOHYMKBUOXEB-RYNSOKOISA-N 0.000 description 1
- IJCWFDPJFXGQBN-RYNSOKOISA-N [(2R)-2-[(2R,3R,4S)-4-hydroxy-3-octadecanoyloxyoxolan-2-yl]-2-octadecanoyloxyethyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCCCCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCCCCCCCCCCCC IJCWFDPJFXGQBN-RYNSOKOISA-N 0.000 description 1
- POXJXWXPDYFTJM-ZAFYKAAXSA-N [(2r)-2-[(1s)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2h-furan-3-yl] dihydrogen phosphate Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1OP(O)(O)=O POXJXWXPDYFTJM-ZAFYKAAXSA-N 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 125000003289 ascorbyl group Chemical group [H]O[C@@]([H])(C([H])([H])O*)[C@@]1([H])OC(=O)C(O*)=C1O* 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- SHZIWNPUGXLXDT-UHFFFAOYSA-N caproic acid ethyl ester Natural products CCCCCC(=O)OCC SHZIWNPUGXLXDT-UHFFFAOYSA-N 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- VJNCICVKUHKIIV-UHFFFAOYSA-N dopachrome Chemical compound O=C1C(=O)C=C2NC(C(=O)O)CC2=C1 VJNCICVKUHKIIV-UHFFFAOYSA-N 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- SFFVATKALSIZGN-UHFFFAOYSA-N hexadecan-7-ol Chemical compound CCCCCCCCCC(O)CCCCCC SFFVATKALSIZGN-UHFFFAOYSA-N 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000008099 melanin synthesis Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 229940105132 myristate Drugs 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000001603 reducing effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 239000001570 sorbitan monopalmitate Substances 0.000 description 1
- 235000011071 sorbitan monopalmitate Nutrition 0.000 description 1
- 229940031953 sorbitan monopalmitate Drugs 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 229960005078 sorbitan sesquioleate Drugs 0.000 description 1
- 239000001589 sorbitan tristearate Substances 0.000 description 1
- 235000011078 sorbitan tristearate Nutrition 0.000 description 1
- 229960004129 sorbitan tristearate Drugs 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 150000003700 vitamin C derivatives Chemical class 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
【構成】A)L−アスコルビン酸およびその誘導体から選ばれる一種または二種以上、B)高級アルコール、C)ソルビタン脂肪酸エステル、D)ヤシ油脂肪酸ショ糖エステル、並びにE)カルボキシビニルポリマー、キサンタンガム、変性バレイショデンプン、ヒアルロン酸ナトリウムから選ばれる一種または二種以上の増粘剤を含有することを特徴とする乳化型皮膚外用剤。
【選択図】なし
Description
実施例1〜14、比較例1〜17
表1〜表3に記載の処方に従って、下記の方法により乳液を製造し、保存安定性を評価した。保存安定性の試験・評価方法は次の通りである。評価結果は表4の通りである。
(1)保存安定性試験法
各試料を45℃、室温、0℃に3ヶ月間保存し、色、匂い、性状の変化を以下のように評価した。
(色)
◎:変化なし。
○:ごくわずかに変色。
△:やや変色。
×:強く変色。
(匂い)
◎:変化なし。
○:ごくわずかに変臭。
△:やや変臭。
×:強い変臭。
(性状)
◎:変化なし。
△:ごくわずかに分離、もしくはごくわずかに流動性の変化がある。
×:分離もしくは流動性なし。
(2)皮膚色明度回復試験法
被験者20名の背部皮膚にUV−B領域の紫外線を最小紅斑量の2倍照射し、試料塗布
部位と非塗布部位を設定して各々の皮膚の基準明度(V0値,V0’値)を測定した。引き続いて塗布部位には試料を1日2回ずつ15週間連続塗布した後、3,6,9,12,15週間後の塗布部位および非塗布部位の皮膚の明度(Vn値,Vn’値)を測定し、下記の判定基準にしたがって皮膚色の回復を評価した。尚、皮膚の明度(マンセル表色系V値)は高速分光色彩計で測定して得られたX,Y,Z値より算出した。また評価は被験者20名ついて、3週間後の評価点の平均値で示した。
評価点 判断基準
各週間の皮膚明度の回復値の差が下式を満足する試料
5 ΔV−ΔV’≧0.12
4 0.12>ΔV−ΔV’≧0.08
3 0.08>ΔV−ΔV’≧0.04
2 0.04>ΔV−ΔV’≧0
1 0>ΔV−ΔV’
ΔV :塗布部位の回復値 (Vn−V0)
ΔV’:非塗布部位の回復値(Vn’−V0’)
(A),(B)の各成分をそれぞれ70℃に加熱し、完全溶解した後、油相部を水相部に混合し、乳化機にて乳化処理する。乳化物を冷却し、50℃にて(C)を加え、さらに終温30℃まで冷却する。
実施例15[クリーム]
表5の組成により本発明のクリームを下記の調製法によって調製した。
(A),(B)の各成分をそれぞれ70℃に加熱し、完全溶解した後、油相部を水相部に混合し、乳化機にて乳化処理する。乳化物を冷却し、50℃にて(C)を加え、さらに終温30℃まで冷却する。
特性
この実施例15のクリームは保存安定性、美白効果に優れたものである。
実施例16[サンスクリーン]
表6の組成により本発明のサンスクリーンを下記の調製法によって調製した。
(A),(B)の各成分をそれぞれ70℃に加熱し、完全溶解した後、油相部を水相部に混合し、乳化機にて乳化処理する。乳化物を冷却し、50℃にて(C)を加え、さらに終温30℃まで冷却する。
特性
この実施例16のサンスクリーンは保存安定性、美白効果に優れたものである。
Claims (2)
- A)L−アスコルビン酸およびその誘導体から選ばれる一種または二種以上、B)高級アルコール、C)ソルビタン脂肪酸エステル、D)ヤシ油脂肪酸ショ糖エステル、並びにE)カルボキシビニルポリマー、キサンタンガム、変性バレイショデンプン、ヒアルロン酸ナトリウムから選ばれる一種または二種以上の増粘剤を含有することを特徴とする乳化型皮膚外用剤。
- B)高級アルコールが、ステアリルアルコール、イソステアリルアルコール、セチルアルコール、ベヘニルアルコールから選ばれる一種または二種以上であることを特徴とする請求項1に記載の乳化型皮膚外用剤。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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JP2004194603A JP4137016B2 (ja) | 2004-06-30 | 2004-06-30 | 乳化型皮膚外用剤 |
Applications Claiming Priority (1)
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JP2004194603A JP4137016B2 (ja) | 2004-06-30 | 2004-06-30 | 乳化型皮膚外用剤 |
Publications (2)
Publication Number | Publication Date |
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JP2006016327A true JP2006016327A (ja) | 2006-01-19 |
JP4137016B2 JP4137016B2 (ja) | 2008-08-20 |
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JP2004194603A Expired - Fee Related JP4137016B2 (ja) | 2004-06-30 | 2004-06-30 | 乳化型皮膚外用剤 |
Country Status (1)
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JP (1) | JP4137016B2 (ja) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009286735A (ja) * | 2008-05-29 | 2009-12-10 | Shiseido Co Ltd | 皮膚外用剤 |
JP2012082152A (ja) * | 2010-10-07 | 2012-04-26 | Kao Corp | 水中油型乳化組成物 |
JP2014028762A (ja) * | 2012-07-31 | 2014-02-13 | Kao Corp | 乳化型クレンジング化粧料 |
JP2014114230A (ja) * | 2012-12-07 | 2014-06-26 | Kao Corp | 水中油型乳化組成物 |
JP2018052875A (ja) * | 2016-09-29 | 2018-04-05 | 株式会社マンダム | 乳化化粧料 |
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2004
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009286735A (ja) * | 2008-05-29 | 2009-12-10 | Shiseido Co Ltd | 皮膚外用剤 |
JP2012082152A (ja) * | 2010-10-07 | 2012-04-26 | Kao Corp | 水中油型乳化組成物 |
JP2014028762A (ja) * | 2012-07-31 | 2014-02-13 | Kao Corp | 乳化型クレンジング化粧料 |
JP2014114230A (ja) * | 2012-12-07 | 2014-06-26 | Kao Corp | 水中油型乳化組成物 |
JP2018052875A (ja) * | 2016-09-29 | 2018-04-05 | 株式会社マンダム | 乳化化粧料 |
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