JP2005290379A - Perfume composition having physiological or psychological therapeutic effect - Google Patents
Perfume composition having physiological or psychological therapeutic effect Download PDFInfo
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Abstract
Description
本発明は、ストレス緩和及び鎮静効果を有する香料組成物に関するもので、更に詳細には、生理・心理的症状に対する治療力を活用することで、使用者の心身に安らぎを与える新たな機能を有する香料組成物に関するものである。 The present invention relates to a fragrance composition having a stress relieving and sedative effect. More specifically, the present invention has a new function of giving comfort to a user's mind and body by utilizing therapeutic power against physiological and psychological symptoms. The present invention relates to a fragrance composition.
現代社会は、過渡な精神的ストレスを起こす要因が多く、ストレスを原因とする疾病が増えている。そのため、ストレス解消のための様々な方法が開発されている。特に、香りを用いた芳香療法（ａｒｏｍａｔｈｅｒａｐｙ）への関心が高く、これは、例えば、ストレスの多い職場や公共場所などで、快適な環境を作るための手段として流行っている。また、化粧品業界においても、このような傾向を反映してストレスを含む心理的要因を考慮し、化粧品における香り効果の実証がなされている。 In modern society, there are many factors that cause transient mental stress, and diseases caused by stress are increasing. Therefore, various methods for relieving stress have been developed. In particular, there is a great interest in aromatherapy using fragrance, which is popular as a means for creating a comfortable environment in, for example, a stressful workplace or public place. Also in the cosmetics industry, fragrance effects in cosmetics have been demonstrated in consideration of psychological factors including stress reflecting such a tendency.
そこで、本発明者等は、各種植物から抽出した香りが、人体の生理・心理的状態に対してどのような効果を与えるかについて検討した。本発明では、まず、自然の香りを最大限に再現した香料組成物（エッセンシャルオイルベース）を調製した。そして、この香料に対し、脳波（ＥＥＧ）、自律神経系（ＥＣＧ（心電図））、ＳＫＴ（皮膚温度）、ＧＳＲ（皮膚抵抗）における生理信号を測定した。その結果、本発明で提供する香料（エッセンシャルオイルベース９）が、人体に対し生理・心理的治療効果があることを見出し、本発明を完成した。 Therefore, the present inventors examined what effect the fragrance extracted from various plants has on the physiological and psychological state of the human body. In the present invention, first, a fragrance composition (essential oil base) that reproduces the natural scent to the maximum was prepared. And the physiological signal in an electroencephalogram (EEG), an autonomic nervous system (ECG (electrocardiogram)), SKT (skin temperature), and GSR (skin resistance) was measured with respect to this fragrance | flavor. As a result, it was found that the fragrance (essential oil base 9) provided by the present invention has a physiological and psychological therapeutic effect on the human body, thereby completing the present invention.
すなわち、本発明の目的は、人体に対し生理・心理的治療効果を有する香料組成物を提供することにある。 That is, an object of the present invention is to provide a fragrance composition having a physiological / psychological therapeutic effect on the human body.
本発明の更に他の目的は、上記香料組成物を含有することにより、ストレス緩和及び鎮静効果を有する化粧料組成物を提供することにある。 Still another object of the present invention is to provide a cosmetic composition having a stress relieving and sedative effect by containing the above fragrance composition.
上記目的を達成するために、本発明は、レモン油、パイン油、ラベンダー油、オレンジ油、ユーカリ油、ゼラニウム油、ローズマリー油、イランイラン油及びアルモワーズ油を含有することを特徴とする香料組成物を提供する。 To achieve the above object, the present invention comprises a fragrance composition comprising lemon oil, pine oil, lavender oil, orange oil, eucalyptus oil, geranium oil, rosemary oil, ylang ylang oil and armows oil. Offer things.
本発明による香料組成物は、好ましくは、組成物の総重量に対し、レモン油５〜５０重量％、パイン油１〜３０重量％、ラベンダー油５〜５０重量％、オレンジ油０．５〜３５重量％、ユーカリ油１〜１０重量％、ゼラニウム油０．５〜２０重量％、ローズマリー油１〜３０重量％、イランイラン油０．１〜２５重量％及びアルモワーズ油０．１〜１０重量％含有することを特徴とする。 The fragrance composition according to the present invention is preferably 5 to 50% by weight of lemon oil, 1 to 30% by weight of pine oil, 5 to 50% by weight of lavender oil, 0.5 to 35% of orange oil, based on the total weight of the composition. Wt%, Eucalyptus oil 1-10 wt%, geranium oil 0.5-20 wt%, rosemary oil 1-30 wt%, ylang ylang oil 0.1-25 wt% and armoise oil 0.1-10 wt% It is characterized by containing.
以下、本発明を、より具体的に説明する。
本発明の香料組成物を構成している香料等は、芳香療法に用いられているもので、集中力を高めたり、不眠症の解消に効果がある。以下、それを具体的に説明する。
Hereinafter, the present invention will be described more specifically.
The fragrance | flavor etc. which comprise the fragrance | flavor composition of this invention are used for aroma therapy, and are effective in improving concentration and eliminating insomnia. This will be specifically described below.
本発明に用いられるレモン油は、薄緑を呈する黄色い液体で、明るくて爽快なシトラス（ｃｉｔｒｕｓ）系の香りを放っており、集中力を高める効果がある。 The lemon oil used in the present invention is a light yellowish yellow liquid, has a bright and refreshing citrus scent, and has the effect of increasing concentration.
パイン油は、薄黄色か、もしくは無色の液体で、松の香りを放っており、痛み緩和、神経衰弱、疲労、ストレス解消に効果がある。 Pine oil is a light yellow or colorless liquid that gives off a pine scent and is effective in relieving pain, nervous breakdown, fatigue, and stress relief.
ラベンダー油は、無色か、もしくは薄黄色の液体で、甘ったるい花の蜂蜜の香りやバルサムの木（ｂａｌｓａｍ ｔｒｅｅ）の香りを放っており、不眠症、頭痛、生理痛解消、胸騒ぎに効果がある。 Lavender oil is a colorless or light yellow liquid that has a sweet scented honey scent and a balsam tree scent.
オレンジ油は、濃い黄色か、もしくは茶色を呈する黄色の流動液体で、爽快で且つ甘いみかん類の香りを放っており、不眠症を解消する効果がある。 Orange oil is a dark yellow or brownish yellow liquid that has a refreshing and sweet orange scent and is effective in resolving insomnia.
ユーカリ油は、無色の流動液で、熟成時、黄色を呈し、カンファー（ｃａｍｐｈｏｒ）の香りや木のあまい香りを放っている。 Eucalyptus oil is a colorless fluid that, when ripened, has a yellow color and gives off a camphor or woody scent.
ゼラニウム油は、オリーブ色の液体で、甘くて重厚なミント香りを放っており、憂鬱症の治療に効果がある。 Geranium oil is an olive-colored liquid with a sweet and profound mint scent that is effective in treating depression.
ローズマリー油は、無色か、もしくは薄黄色の流動液で、強くて新鮮なミント香りや木の香りを放っており、頭をすっきりしたり、記憶力を高めたりして、疲労や頭痛の解消に効果がある。 Rosemary oil is a colorless or light yellow fluid that gives off a strong, fresh mint scent and woody scent, which can help to relieve fatigue and headaches by refreshing the head and improving memory. effective.
イランイラン油は、薄い黄色のオイリー液体で、強くて若干辛い香りを持っており、性的不感症、ストレス、神経性緊張、不眠症の解消によい。 Ylang Ylang Oil is a pale yellow oily liquid with a strong and slightly spicy scent that is good for relieving sexual insensitivity, stress, nervous tension and insomnia.
アルモワーズ油は、無色か、もしくは薄黄色の液体で、蓬の香りを放っており、生理痛解消、子宮や膀胱の強化、及び神経の鎮静効果がある。 Armoise oil is a colorless or light yellow liquid that gives off the scent of amber, relieving menstrual pain, strengthening the uterus and bladder, and sedating the nerves.
本発明では、上記した香料等による生理・心理的治療効果を究明するために、左右前頭部におけるα波の平均周波数及び変動リズムの傾斜度を比較し、一連の生理信号-ＥＣＧ、ＳＫＴ、ＧＳＲ-を測定した。後述する実験例の結果から明らかなように、上記した本発明の複合香を用いることにより、左右前頭部における変動リズムの傾斜度が、有意的に増加する傾向が現れ、更に右脳（興奮、鎮静感と関連）に比べて左脳（快感、不快感と関連）の方が、より著しい傾向を示した。すなわち、本発明における複合香の組成は、ストレス緩和を与えるとともに、鎮静効果があった。更に他の生理信号の測定においても、本発明の複合香組成は、生理・心理的症状に対する治療効果があった。以上のように、上記複合香を有効成分として含有することにより、本発明の化粧料組成物は、ストレス緩和及び鎮静効果を提供することができる。 In the present invention, in order to investigate the physiological and psychological treatment effects by the above-described fragrances, the average frequency of α waves and the slope of the fluctuation rhythm in the left and right frontal regions are compared, and a series of physiological signals -ECG, SKT, GSR- was measured. As will be apparent from the results of the experimental examples described later, by using the above-described compound incense of the present invention, the inclination of the fluctuation rhythm in the left and right frontal areas tends to increase significantly, and the right brain (excitement, The left brain (related to pleasure and discomfort) showed a more prominent tendency than that related to sedation. That is, the composition of the composite fragrance in the present invention has a sedative effect while providing stress relaxation. Further, in the measurement of other physiological signals, the composite fragrance composition of the present invention has a therapeutic effect on physiological and psychological symptoms. As described above, the cosmetic composition of the present invention can provide a stress relieving and sedative effect by containing the complex fragrance as an active ingredient.
本発明は、また、上記香料組成物を含有することにより、ストレス緩和及び鎮静効果を有する化粧料組成物を提供する。 The present invention also provides a cosmetic composition having a stress relieving and sedative effect by containing the above fragrance composition.
本発明による香料組成物を有効成分として含有する化粧料組成物は、その剤型において特に限定はされないが、望ましくは、水中油型として提供することがよい。これは、香りが主に油相に溶けており、香りを徐々に放出するためには水中油型の方が望ましいからで、更に、皮膚に塗布した時にも、水中油型の方が、油中水型に比べて、べたつきにくく、さらっとしたよい使用感が得られる。 The cosmetic composition containing the fragrance composition according to the present invention as an active ingredient is not particularly limited in its dosage form, but desirably it is provided as an oil-in-water type. This is because the scent is mainly dissolved in the oil phase, and the oil-in-water type is preferable for gradually releasing the scent. Furthermore, when applied to the skin, the oil-in-water type is more oily. Compared to the medium water type, it is less sticky and provides a smooth and comfortable feeling.
本発明による化粧料組成物において、上記香料組成物は、化粧料組成物の総重量に対して、０．１〜１．０重量％含有することが好ましい。香料の含量が、０．１重量％未満では、香りの効果が期待しにくく、１．０重量％を超えると皮膚刺激感が現れることがあるため好ましくない。このような観点から、上記香料組成物を、好ましくは、０．２〜０．４重量％、更に好ましくは、０．２５重量％含有することがよい。 In the cosmetic composition according to the present invention, the fragrance composition is preferably contained in an amount of 0.1 to 1.0% by weight based on the total weight of the cosmetic composition. If the content of the fragrance is less than 0.1% by weight, it is difficult to expect a scent effect, and if it exceeds 1.0% by weight, a skin irritation may appear, which is not preferable. From such a viewpoint, the fragrance composition is preferably contained in an amount of 0.2 to 0.4% by weight, and more preferably 0.25% by weight.
以下、実験例及び実施例を通じて本発明をより具体的に説明するが、本発明は、これらの例に限定されるものではない。 Hereinafter, the present invention will be described more specifically through experimental examples and examples. However, the present invention is not limited to these examples.
本発明では、生理・心理的症状に対する香りの治療力を活用することで、ストレス緩和及び鎮静効果を具現し、これによって、香りを用いて使用者の心身に安らぎを与える新たな機能を有する組成物を提供することができる。 In the present invention, by utilizing the therapeutic power of fragrance for physiological and psychological symptoms, a stress relieving and sedative effect is realized, and thereby a composition having a new function of giving a user's mind and body comfort using the fragrance Things can be provided.
（実施例１）
本発明による香料組成物の一実施形態として、下記の表１の組成に基づき、エッセンシャルオイルベース９を作製した（実施例１）。また、下記成分等を、表１に示す組成比で混合して香料組成物を作製した。
As an embodiment of the fragrance composition according to the present invention, an
（実験例１）香料組成物の生理・心理的治療効果の評価
本発明による香料組成物の生理・心理的治療効果を客観的に評価するために、上記実施例１で作製したエッセンシャルオイルベース９を用いて、中枢神経系の脳波（ＥＥＧ）におけるα波周波数の変動リズム係数、自律神経系のＥＣＧ、ＳＫＴ、ＧＳＲ等の生理信号を測定した。更に、主観的感情の評価（ＰＯＭＳ）も実施した。その具体的な方法は、下記の通りである。
(Experimental Example 1) Evaluation of Physiological / Psychological Treatment Effect of Perfume Composition In order to objectively evaluate the physiological / psychological treatment effect of the fragrance composition according to the present invention, the
１．香料組成物
実施例１の香料組成物を実験に利用した。
1. Fragrance composition The fragrance composition of Example 1 was used in the experiment.
２．臨床実験
被験者は、２０〜３０代の健康な成人女性１０人（年齢：２７．６±６．９歳）を対象とした。被験者としては、鼻の手術経験がなく、鼻の疾患を有しておらず、更に薬物を服用していない人を選んだ。実験の前に、嗅覚実験に影響を及ぼすような喫煙、飲酒、カフェイン、薬物等の摂取を禁じた。
2. Clinical experiment Subjects were 10 healthy adult women in their 20s to 30s (age: 27.6 ± 6.9 years). The subjects were those who had no nasal surgery experience, no nasal disease, and were not taking any drugs. Prior to the experiment, smoking, drinking, caffeine, drugs, etc., which affect olfactory experiments, were prohibited.
３．実験条件
実験は、嗅覚のチャンバーで実施した。チャンバーの内部は、嗅覚の順応を軽減するための目的として、吸排気及び防音装置を備え、銅板で絶縁した５．５×３．５×２．４ｍの規格で構築した。
3. Experimental conditions Experiments were performed in an olfactory chamber. The interior of the chamber was constructed with a standard of 5.5 × 3.5 × 2.4 m, equipped with intake / exhaust and soundproofing devices and insulated with a copper plate for the purpose of reducing adaptation of the olfactory sense.
実験に際しては、内部温度（２４±１℃）、相対湿度（５０±１０％）、照度（１５０
〜２００Ｌｘ）を維持するようにした。
In the experiment, internal temperature (24 ± 1 ° C.), relative humidity (50 ± 10%), illuminance (150
˜200 Lx).
実験は、ストレスを負荷した後、エッセンシャルオイルベース９を注入する条件で実施した。
The experiment was performed under the condition that the
ストレス負荷における数字の加算作業は、内田・クレペリン精神作業検査に基づく計算方法にしたがい、無作為に配列した（１行１００字）数字を、隣り合う数字同士で加算し、６０秒ごとく行を変えながら５分間行い、正答率９０％以下のデータの場合は、分析から除いた。使用した内田・クレペリン精神作業検査紙の一部分を図１に示した。 Addition of numbers under stress load is performed according to a calculation method based on the Uchida-Kraepelin mental work test. Numbers randomly arranged (100 characters per line) are added together between adjacent numbers, and the line is changed every 60 seconds. For 5 minutes, data with a correct answer rate of 90% or less were excluded from the analysis. A part of the Uchida-Kraepelin mental work test paper used is shown in FIG.
４．実験の順序
全体実験進行プロトコルは、次の通りである。
4). Sequence of experiment The protocol for the entire experiment is as follows.
(1)各測定項目にセンサー付着
(2)安定した状態でＥＥＧ、ＥＣＧ、ＳＫＴ、及びＧＳＲを測定
(3)５分間における数字の加算作業中には、ＥＣＧ、ＳＫＴ、及びＧＳＲを連続的に測定
(4)数字の加算作業を行った後、ＥＥＧを測定
(5)主観的感情評価（ＰＯＭＳ）を実施
(6)エッセンシャルオイルベース９（実施例１）を注入した後、ＥＥＧ、ＥＣＧ、ＳＫＴ、及びＧＳＲを測定
(7)主観的感情評価（ＰＯＭＳ）を実施
(1) Sensor attached to each measurement item
(2) Measure EEG, ECG, SKT, and GSR in a stable state
(3) ECG, SKT, and GSR are continuously measured during the addition of numbers for 5 minutes.
(4) Measure EEG after adding numbers
(5) Conduct subjective emotion assessment (POMS)
(6) After injecting the essential oil base 9 (Example 1), EEG, ECG, SKT, and GSR are measured.
(7) Conduct subjective emotional assessment (POMS)
５．測定項目
脳波測定においては、左右前頭葉におけるα波周波数の変動リズム係数が、自動的に算出される、携帯式で且つ小型な快適感評価装置（日本生命工学工業技術研究所開発）を用い、左右前頭葉におけるα波の平均周波数及び変動リズム係数を測定した。
5). Measurement items In the electroencephalogram measurement, a portable and small comfort evaluation device (developed by Nippon Life Science and Technology Research Institute), which automatically calculates the fluctuation rhythm coefficient of the α wave frequency in the left and right frontal lobes, The average frequency and fluctuation rhythm coefficient of α waves in the frontal lobe were measured.
生理信号の測定においては、バイオアンプ（ＭＰ１００）を用い、心電図：１チャンネル（ＣＭ５誘導法）、ＧＳＲ：１チャンネル（左手の人差し指と薬指）、ＳＫＴ：１チャンネル（左手の中指）をそれぞれ測定した。心電図においてアールピーク（Ｒ−ｐｅａｋ）は、１次微分によるゼロクロシング（ｚｅｒｏ−ｃｒｏｓｓｉｎｇ）の方法を用いて検出し、検出したアールピークからＲ−Ｒ間隔（ＲＲＩ）を計算した。ＧＳＲ、ＳＫＴの分析は、各信号振幅の平均及び標準偏差を計算し、比較分析を行った。分析ソフトウェアとしては、Ａｃｑｋｎｏｗｌｅｄｇｅ３．５を利用した。 In the measurement of physiological signals, a bioamplifier (MP100) was used to measure ECG: 1 channel (CM5 induction method), GSR: 1 channel (left index finger and ring finger), and SKT: 1 channel (left hand middle finger). . In the electrocardiogram, the R-peak was detected using a zero-crossing method based on first-order differentiation, and the RR interval (RRI) was calculated from the detected R-peak. For the analysis of GSR and SKT, the average and standard deviation of each signal amplitude was calculated and comparative analysis was performed. As analysis software, Acqknowledge 3.5 was used.
主観的感情評価（ＰＯＭＳ）は、日本の６５項目版（ＰＯＭＳ）を翻訳して用い、数字の加算作業を行うとともにエッセンシャルオイルベース９注入後の感情を評価した。 For subjective emotional evaluation (POMS), the Japanese 65-item version (POMS) was translated and used to add numbers and evaluate emotions after 9 essential oil bases were injected.
６．統計処理
二つの条件（ストレスの負荷及びエッセンシャルオイルベース９の注入）間の比較は、ＳＰＳＳ１０を用い、ｔ検定によって実施した。
6). Statistical treatment Comparison between the two conditions (stress loading and injection of essential oil base 9) was performed by SP test using SPSS10.
７．実験結果
α波の平均周波数、変動リズムの傾斜度
二つの条件で左右前頭葉におけるα波の平均周波数を比較した結果、左脳が９．２７〜９．５２Ｈｚ、右脳が１０．１５〜１０．２７Ｈｚに分布し、右脳の方が左脳に比べて増加したものの、左右間に有意差はなかった（図２）。
7). Experimental result
As a result of comparing the average frequency of the α wave in the left and right frontal lobes under the two conditions of the average frequency of the α wave and the gradient of the fluctuation rhythm , the left brain is distributed in 9.27 to 9.52 Hz and the right brain is distributed in 10.15 to 10.27 Hz. Although the right brain increased compared to the left brain, there was no significant difference between the left and right sides (FIG. 2).
変動リズムの傾斜度においては、全体的に、右脳に比べて左脳の方が大きい傾向を示した。条件間においては、左右脳の両方とも、ストレスの負荷に比べて、エッセンシャルオイルベース９の注入の方が、傾斜度が有意に増加した（左脳：ｐ＜０．００１、右脳：ｐ＜０．１）（図３）。
Overall, the slope of the variable rhythm tended to be greater in the left brain than in the right brain. Between conditions, the slope of the
快適度
α波周波数の変動リズム係数の大きさ及び変動リズム係数の傾斜度から算出した快適度においては、ストレスの負荷に比べて、エッセンシャルオイルベース９の注入の方が、有意に増加した（ｐ＜０．０５）（図４）。
In the comfort level calculated from the magnitude of the fluctuation rhythm coefficient of the degree of comfort α wave frequency and the slope of the fluctuation rhythm coefficient, the injection of the
吉田ベクトルモデル
α波の変動リズム傾斜度及び快適度で算出した吉田ベクトルモデルにおいては、ストレスの負荷に比べて、エッセンシャルオイルベース９の注入の方が、被験者の大体が快・覚醒の傾向を示した（図５）。
Yoshida vector model In the Yoshida vector model calculated with the fluctuation rhythm inclination and comfort level of α wave, the injection of the
平均Ｒ−Ｒ間隔（ＲＲＩ）、皮膚温度（ＳＫＴ）、皮膚抵抗（ＧＳＲ）
ＲＲＩにおいては、ストレスの負荷に比べて、エッセンシャルオイルベース９の注入の方が、有意に増加した（ｐ＜０．００１）（図６ａ）。
Average RR interval (RRI), skin temperature (SKT), skin resistance (GSR)
In RRI, the injection of the
ＳＫＴにおいては、ストレスの負荷に比べて、エッセンシャルオイルベース９の注入の方が増加したものの、条件による有意差異は出なかった（図６ｂ）。
In SKT, the injection of the
ＧＳＲにおいては、ストレスの負荷に比べて、エッセンシャルオイルベース９の注入の方が、有意に減少した（ｐ＜０．０１）（図６ｃ）。
In the GSR, the injection of the
主観的感情評価（ＰＯＭＳ）
ストレスの負荷及びエッセンシャルオイルベース９の注入後、主観的感情の評価を施した結果、「緊張」、「憂鬱」、「怒り」、「疲労」、「混乱」の項目において、ストレスの負荷に比べて、エッセンシャルオイルベース９の注入の方が項目別の得点数が減少し、とくに「緊張」、「疲労」、「混乱」（ｐ＜０．１）、「怒り」の項目においては、有意に減少した（ｐ＜０．０５）（図７）。
Subjective emotion assessment (POMS)
As a result of the evaluation of subjective emotions after the stress load and the
以上の結果から、本発明における複合型組成は、ストレスに対し生理・心理的治療効を有することを確認することができた。 From the above results, it was confirmed that the composite composition of the present invention has a physiological / psychological therapeutic effect against stress.
（実施例２）
実験例１の結果に基づき、上記実施例１の香料組成物を有効成分として含有する水中油型の化粧料を組成した。製剤の組成は、下記の表２に示した。
Based on the results of Experimental Example 1, an oil-in-water cosmetic containing the fragrance composition of Example 1 as an active ingredient was prepared. The composition of the formulation is shown in Table 2 below.
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| WO2006118074A1 (en) * | 2005-04-26 | 2006-11-09 | Nature Technology Inc. | Composition for inducing sleep containing vegetable essential oil component as the active component, transdermal absorption type sleep inducing agent containing the composition and method of producing the same |
| JP2012521416A (en) * | 2009-03-23 | 2012-09-13 | 株式会社アモーレパシフィック | Fragrance and cosmetic composition having stress relieving and sedative effects |
| JP2018510941A (en) * | 2015-03-16 | 2018-04-19 | ジボダン エス エー | Improvements in or related to organic compounds |
| KR102060957B1 (en) | 2019-09-30 | 2019-12-31 | 강원대학교산학협력단 | Deep forest mix aroma composition for enhancing concentration of human brain and uses thereof |
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