JP2005239550A - Fatigue prophylactic and fatigue recovering agent - Google Patents
Fatigue prophylactic and fatigue recovering agent Download PDFInfo
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- JP2005239550A JP2005239550A JP2004047180A JP2004047180A JP2005239550A JP 2005239550 A JP2005239550 A JP 2005239550A JP 2004047180 A JP2004047180 A JP 2004047180A JP 2004047180 A JP2004047180 A JP 2004047180A JP 2005239550 A JP2005239550 A JP 2005239550A
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- fatigue
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Abstract
Description
本発明は酵母エキスを有効成分として含有する肉体の疲労予防・疲労回復剤に関する。 The present invention relates to a physical fatigue prevention / recovery agent containing yeast extract as an active ingredient.
従来から、肉体疲労の予防又は回復効果を目的として、種々の疲労回復飲食品もしくは医薬品が提供されてきた。例えば畜肉を酸、アルカリもしくは酵素処理して得たエキス類もしくはその画分(特許文献1、特許文献2参照)、ハーブ類の混合物(特許文献3参照)、ビタミンと医薬品の混合物等(特許文献4参照)があげられる。しかしながら、近年牛海綿状脳症等の問題から動物質のエキス・調味料が忌避される傾向があり、また天然噂好の高まりから人工的な混合物よりも天然に近い食材が好まれるようになってきた。 Conventionally, various fatigue-recovered foods and drinks or pharmaceuticals have been provided for the purpose of preventing or recovering physical fatigue. For example, extracts obtained by treating livestock meat with acid, alkali or enzyme or fractions thereof (see Patent Document 1 and Patent Document 2), mixtures of herbs (see Patent Document 3), mixtures of vitamins and pharmaceuticals, etc. (Patent Document) 4). However, in recent years, there has been a tendency for animal extracts and seasonings to be avoided due to problems such as bovine spongiform encephalopathy, and the growing popularity of natural rumors has led to the preference for ingredients that are closer to natural than artificial mixtures. It was.
ビール酵母やパン酵母を始めとするサッカロミセス酵母は、天然のビタミンB群、アミノ酸、ミネラル等をバランス良く含有しており、ビールやパンの製造に使われた後も有効活用されている。例えば乾燥酵母は我が国において70年以上にわたって医薬品、食品原料として使われており、栄養価と安全性の高い素材として認知されている。一方酵母から抽出したエキスも天然の調味料として様々な食品に使われているが、乾燥酵母と比較して人間の健康増進を目的とした用途には殆ど使われておらず、酵母エキスの肉体疲労予防・回復効果に関する報告は現時点では見あたらない。
従って本発明の目的は、天然の栄養素をバランスよく配合する酵母エキスを有効成分として使用し、人畜共通伝染病の発生源となり得ないなど安全性に優れ、酵母エキス以外の有効成分の同時添加・無添加に拘わらず、優れた肉体の疲労予防・疲労回復効果を発揮しうる疲労予防・疲労回復剤ならびに該剤を含有する医薬組成物および飲食品を提供することである。 Therefore, the purpose of the present invention is to use a yeast extract containing natural nutrients in a well-balanced manner as an active ingredient, which is excellent in safety such as being unable to be a source of zoonotic diseases, and simultaneously adding active ingredients other than yeast extract. It is intended to provide an anti-fatigue / fatigue-recovering agent capable of exhibiting excellent physical fatigue prevention / recovery effect, and a pharmaceutical composition and food / beverage product containing the agent, regardless of the addition.
本発明は上記目的を達成するためになされたもので、酵母より抽出したエキスが、これまで知られていなかったような生理活性を有することを動物実験により確認して本発明を完成するに至った。すなわち本発明は、酵母エキスを有効成分とする肉体疲労予防・改善機能を持つ飲食品もしくは医薬品を提供する。 The present invention has been made in order to achieve the above-mentioned object, and it has been confirmed by animal experiments that an extract extracted from yeast has physiological activity that has not been known so far, and the present invention has been completed. It was. That is, this invention provides the food-drinks or pharmaceutical which has the function of preventing and improving physical fatigue which uses yeast extract as an active ingredient.
本発明によれば、酵母エキスを原料として、肉体疲労予防・回復活性を有する物質を得ることができた。更にこれを、医薬品や飲食品の材料として容易に利用することができた。 According to the present invention, a substance having physical fatigue prevention / recovery activity can be obtained using yeast extract as a raw material. Furthermore, it could be easily used as a material for medicines and foods and drinks.
酵母エキスには市販品、自家製造品のどちらを使用しても良い。自家製造する場合には、エキスの原料には如何なる酵母を用いても良いが、好ましくはサッカロミセス属の酵母、特にビール酵母が推奨される。酵母エキスは、一般的には、酵母の自己消化、消化酵素処理、アルカリ、酸あるいは熱水処理、もしくは物理的損傷等により細胞壁の物質透過性を高め、水又は有機溶媒単独、あるいはこれらの混合物により、細胞内に含まれる可溶性成分を抽出することにより得られる。酵母エキスは、溶媒に溶解した状態で使用することもできるが、真空乾燥、凍結乾燥等により粉末化しても良い。粉末化に際して、適当な賦形剤を加えても差し支えない。 As the yeast extract, either a commercial product or a homemade product may be used. In the case of homemade production, any yeast may be used as a raw material for the extract, but yeast of the genus Saccharomyces, particularly beer yeast, is recommended. Yeast extract generally increases cell wall material permeability by yeast autolysis, digestive enzyme treatment, alkali, acid or hot water treatment, physical damage, etc., and water or an organic solvent alone or a mixture thereof. Thus, it is obtained by extracting soluble components contained in cells. The yeast extract can be used in a state dissolved in a solvent, but may be pulverized by vacuum drying, freeze drying or the like. An appropriate excipient may be added during powdering.
得られた酵母エキスは、経口の製品として医薬品として用いることができ、また食品素材と混合して飲食品とすることができる。性状としては固体状または液体状を呈し、医薬品としては経口剤として錠剤、カプセル剤、顆粒剤、シロップ剤等の剤型をとる。医薬品として人体に投与するときは、1回あたり1〜1000mg(乾燥重量)/k g体重の量、好ましくは1〜100mg(乾燥重量)/k g体重の量を、1日に1ないし数回経口投与する。 The obtained yeast extract can be used as a pharmaceutical product as an oral product, and can be mixed with a food material to make a food or drink. The property is solid or liquid, and the pharmaceutical is in the form of tablets, capsules, granules, syrups and the like as oral preparations. When administered to the human body as a pharmaceutical, 1 to 1000 mg (dry weight) / kg body weight, preferably 1 to 100 mg (dry weight) / kg body weight, orally once or several times a day To do.
飲食品とする場合、これと混合する食品素材は固形物(粉状、薄片状、塊状など)、半固形物(ゼリー状、水飴状など)、もしくは液状物等のいずれであっても良い。飲食品1gあたりの含有量は、1〜500mg(乾燥重量)であることが望ましい。本発明の酵母エキスを含有する医薬品及び飲食品は、肉体疲労の予防および回復効果を有するので、重労働後の疲労緩和、運動時のパフォーマンス向上など、様々な用途に応用が可能である。
以下、本発明を実施例によってさらに具体的に説明するが、本発明はこれに限定されるものではない。
In the case of a food or drink, the food material to be mixed may be a solid (powder, flake, lump, etc.), a semi-solid (jelly, syrup, etc.), or a liquid. The content per gram of food or drink is preferably 1 to 500 mg (dry weight). Since the pharmaceuticals and foods and drinks containing the yeast extract of the present invention have the effect of preventing and recovering from physical fatigue, they can be applied to various uses such as fatigue reduction after heavy work and performance improvement during exercise.
Hereinafter, the present invention will be described more specifically with reference to examples, but the present invention is not limited thereto.
(錠剤、カプセル剤)
酵母エキス 10.0g
乳糖 75.0g
ステアリン酸マグネシウム15.0g
合 計 100.0g
上記の各重量部を均一に混合し、常法に従って錠剤、カプセル剤とした。
(Tablets and capsules)
Yeast extract 10.0g
Lactose 75.0g
Magnesium stearate 15.0g
Total 100.0g
The above respective parts by weight were uniformly mixed, and tablets and capsules were prepared according to a conventional method.
(散剤、顆粒剤)
酵母エキス 20.0g
澱粉 30.0g
乳糖 50.0g
合 計 100.0g
上記の各重量部を均一に混合し、常法に従って散剤、頼粒剤とした。
(Powder, granule)
Yeast extract 20.0g
Starch 30.0g
Lactose 50.0g
Total 100.0g
Each said weight part was mixed uniformly, and it was set as the powder and the granule according to the conventional method.
(飴)
ショ糖 20.0g
水飴(75%固形分) 70.0g
水 9.4g
着色料 0.45g
香 料 0.05g
酵母エキス 0.1g
合 計 100.0g
上記の各重量部の各成分を用い、常法に従って飴とした。
(candy)
Sucrose 20.0g
Chickenpox (75% solids) 70.0g
9.4 g of water
Coloring material 0.45g
Perfume 0.05g
Yeast extract 0.1g
Total 100.0g
Using each component of each of the above parts by weight, it was made into a candy according to a conventional method.
(清涼飲料水)
果 糖 5.0g
クエン酸 0.2g
香 料 0.1g
色 素 0.15g
アスコルビン酸ナトリウム 0.05g
酵母エキス 0.05g
水 94.45g
合 計 100.0g
上記の各重量部の各成分を用い、常法に従って清涼飲料水とした。
(Soft drink)
Fructose 5.0g
Citric acid 0.2g
Fragrance 0.1g
0.15 g of color
Sodium ascorbate 0.05g
Yeast extract 0.05g
94.45 g of water
Total 100.0g
Using each component of each of the above-mentioned parts by weight, a soft drink was prepared according to a conventional method.
(ジュース)
濃縮ミカン果汁 15.0g
果 糖 5.0g
クエン酸 0.2g
香 料 0.1g
色 素 0.15g
アスコルビン酸ナトリウム 0.05g
酵母エキス 0.05g
水 79.45g
合 計 100.0g
上記の各重量部の各成分を用い、常法に従ってジュースとした。
(juice)
Concentrated tangerine juice 15.0 g
Fructose 5.0g
Citric acid 0.2g
Fragrance 0.1g
0.15 g of color
Sodium ascorbate 0.05g
Yeast extract 0.05g
79.45 g of water
Total 100.0g
Using each component of the above-mentioned parts by weight, juice was prepared according to a conventional method.
(クッキー)
薄力粉 32.0g
全 卵 16.0g
バター 16.0g
砂 糖 25.0g
水 10.7g
ベーキングパウダー 0.2g
酵母エキス 0.1g
合 計 100.0g
上記の各重量部の各成分を用い、常法に従ってクッキーとした。
(cookie)
Soft flour 32.0g
Whole egg 16.0g
16.0g butter
Sand sugar 25.0g
10.7g of water
Baking powder 0.2g
Yeast extract 0.1g
Total 100.0g
Using each component of the above-mentioned parts by weight, a cookie was prepared according to a conventional method.
(酵母エキスの抗疲労作用)
体重25〜28gの雄性ddYマウスを一群 10匹から成る5試験群に分け、それぞれに水、0.004%の酵母エキス水溶液、0.02%の酵母エキス水溶液、0.1%の酵母エキス水溶液、および0.5%の酵母エキス水溶液を飲み水として10日間自由摂取させた。マウスを回転カゴに入れて3時間強制歩行運動(回転カゴの直径37cm、2回転/分)をさせた後、1.5時間にわたってAnime x装置により自発行動量を測定した。酵母エキスの投与により強制運動負荷後の自発行動量が用量依存的かつ有意に増加し、0.1%および0.5%の酵母エキス投与群においては、強制運動負荷による自発行動量の低下が殆ど観察されなかった。
(Anti-fatigue action of yeast extract)
Male ddY mice weighing 25-28 g are divided into 5 test groups consisting of 10 animals, each with water, 0.004% yeast extract aqueous solution, 0.02% yeast extract aqueous solution, 0.1% yeast extract aqueous solution, and 0.5% yeast. The extract aqueous solution was ingested freely as drinking water for 10 days. The mouse was placed in a rotating basket and subjected to a forced walking movement (diameter of the rotating basket of 37 cm, 2 rotations / minute) for 3 hours, and then the amount of self-issued movement was measured with the Anime x apparatus for 1.5 hours. Administration of yeast extract significantly increased the amount of spontaneous movement after forced exercise, and the decrease in spontaneous movement due to forced exercise was almost observed in the 0.1% and 0.5% yeast extract administration groups. Was not.
酵母エキス以外の有効成分の同時添加・無添加に拘わらず、優れた肉体の疲労予防・疲労回復効果を発揮しうる疲労予防・疲労回復剤ならびに該剤を含有する医薬組成物および飲食品を提供することができる。 Provided are a fatigue preventive / fatigue recovering agent capable of exerting excellent fatigue prevention / fatigue recovery effects regardless of simultaneous addition / non-addition of active ingredients other than yeast extract, and pharmaceutical compositions and food / beverage products containing the agent can do.
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JP2004047180A JP2005239550A (en) | 2004-02-24 | 2004-02-24 | Fatigue prophylactic and fatigue recovering agent |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009107962A (en) * | 2007-10-29 | 2009-05-21 | Asahi Breweries Ltd | Yeast extract-containing composition |
KR20140079389A (en) * | 2011-10-06 | 2014-06-26 | 라이온 가부시키가이샤 | Agent for improving quality of sleep |
CN105146666A (en) * | 2015-08-11 | 2015-12-16 | 广东江门生物技术开发中心有限公司 | Solid beverage capable of complementing B vitamins and preparation method of solid beverage |
JP2021020881A (en) * | 2019-07-30 | 2021-02-18 | 三菱商事ライフサイエンス株式会社 | Fatigue recovery agent |
-
2004
- 2004-02-24 JP JP2004047180A patent/JP2005239550A/en not_active Withdrawn
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009107962A (en) * | 2007-10-29 | 2009-05-21 | Asahi Breweries Ltd | Yeast extract-containing composition |
KR20140079389A (en) * | 2011-10-06 | 2014-06-26 | 라이온 가부시키가이샤 | Agent for improving quality of sleep |
KR101961974B1 (en) | 2011-10-06 | 2019-03-25 | 라이온 가부시키가이샤 | Agent for improving quality of sleep |
CN105146666A (en) * | 2015-08-11 | 2015-12-16 | 广东江门生物技术开发中心有限公司 | Solid beverage capable of complementing B vitamins and preparation method of solid beverage |
JP2021020881A (en) * | 2019-07-30 | 2021-02-18 | 三菱商事ライフサイエンス株式会社 | Fatigue recovery agent |
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