JP2005211898A - 流体エジェクタを利用してマイクロカプセルを製造する方法 - Google Patents
流体エジェクタを利用してマイクロカプセルを製造する方法 Download PDFInfo
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- JP2005211898A JP2005211898A JP2005016443A JP2005016443A JP2005211898A JP 2005211898 A JP2005211898 A JP 2005211898A JP 2005016443 A JP2005016443 A JP 2005016443A JP 2005016443 A JP2005016443 A JP 2005016443A JP 2005211898 A JP2005211898 A JP 2005211898A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
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- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
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- Sustainable Development (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicinal Preparation (AREA)
Abstract
【解決手段】 マイクロカプセル(210、212)を製造する方法は、コア成分を含む第1の流体に連通している流体エジェクタ(126)を10キロヘルツよりも高い周波数で作動させて、前記流体エジェクタのそれぞれの作動によって実質的に1つの滴を生成すること(390)、前記第1の流体の所定体積を有する前記実質的に1つの滴を第2の流体内に噴射すること(392)、および、噴射された前記第1の流体のそれぞれの滴について、前記第2の流体内で前記コア成分を含む該マイクロカプセルを生成すること(394)を含む。
【選択図】 図3
Description
126 流体エジェクタ
146 滴
210、212 マイクロカプセル
250 コア材料
252 殻材料(シェル材料)
390 第1の流体の1つの滴を生成するステップ
392 1つの滴を第2の流体内に噴射するステップ
Claims (20)
- マイクロカプセルを製造する方法であって、
コア成分を含む第1の流体に連通している流体エジェクタを10キロヘルツよりも高い周波数で作動させて、前記流体エジェクタのそれぞれの作動によって実質的に1つの滴を生成すること、
所定体積を有する前記第1の流体の前記実質的に1つの滴を第2の流体内に噴射すること、および
噴射された前記第1の流体のそれぞれの滴について、前記第2の流体内で前記コア成分を含む該マイクロカプセルを生成すること
を含むことを特徴とする、マイクロカプセルを製造する方法。 - 前記流体エジェクタを作動させることはさらに、ドロップオンデマンド方式の流体エジェクタを20キロヘルツよりも高い定常状態周波数で作動させて、指定体積の6パーセント内に納まる滴体積の分布範囲を生成することを含むことを特徴とする、請求項1に記載のマイクロカプセルを製造する方法。
- 前記滴を噴射することはさらに、前記滴を、前記第2の流体の流動する液体の薄膜の表面からあらかじめ選択した距離だけ上方で噴射することを含み、
前記流動する液体の薄膜は、流体エジェクタヘッドの流体噴射軸と垂直な向きに流れることを特徴とする、請求項1に記載のマイクロカプセルを製造する方法。 - 少なくとも1つのノズルを浸すことをさらに含み、
ノズル層の少なくとも一部は、前記第2の流体の表面よりも下になっていることを特徴とする、請求項1に記載のマイクロカプセルを製造する方法。 - 前記滴を噴射することはさらに、霧状の前記第2の流体内に前記第1の流体の前記実質的に1つの滴を噴射することを含むことを特徴とする、請求項1に記載のマイクロカプセルを製造する方法。
- 前記滴を噴射することはさらに、ポリアニオンを有する前記第1の流体の前記滴を噴射することを含み、前記コア成分は前記第1の流体内に分散していることを特徴とする、請求項1に記載のマイクロカプセルを製造する方法。
- 前記滴を噴射することはさらに、前記第2の流体と混和しない第1の流体の滴を噴射することを含むことを特徴とする、請求項1に記載のマイクロカプセルを製造する方法。
- 前記滴を噴射することはさらに、前記コア成分とモノマーとを含む第1の流体の滴を、前記モノマーへの共反応体を含む第2の流体内に噴射することを含み、前記モノマーと前記共反応体とは、反応してポリマーの殻を形成し、前記コア成分をカプセル化することを特徴とする、請求項1に記載のマイクロカプセルを製造する方法。
- 前記マイクロカプセルを生成することはさらに、アルギン酸キトサンアルカリ金属のマイクロカプセルを生成することを含むことを特徴とする、請求項1に記載のマイクロカプセルを製造する方法。
- 前記マイクロカプセルを生成することはさらに、コアセルベートを形成することを含むことを特徴とする、請求項1に記載のマイクロカプセルを製造する方法。
- ドロップオンデマンドの流体噴射装置を用いる方法であって、
前記ドロップオンデマンドの流体噴射装置に通電すること、
マイクロカプセルを形成するコア成分を含む第1の流体の実質的に1つの滴を第2の流体内に噴射すること、および
前記第2の流体内でマイクロカプセルを生成することを含み、
前記マイクロカプセルは、前記マイクロカプセルを形成するコア成分を含むことを特徴とする、ドロップオンデマンドの流体噴射装置を用いる方法。 - 前記流体噴射装置の流体噴射軸と垂直な向きに前記第2の流体を流すことをさらに含むことを特徴とする、請求項11に記載のドロップオンデマンドの流体噴射装置を用いる方法。
- 前記流体噴射装置を少なくとも1つの横方向の向きに移動させること、および
前記第1の流体のn個の滴を、n個のあらかじめ選択した横方向の場所において前記第2の流体内に噴射すること
をさらに含むことを特徴とする、請求項12に記載のドロップオンデマンドの流体噴射装置を用いる方法。 - 前記滴を噴射することはさらに、ポリアニオンを有する前記第1の流体の前記滴を噴射することを含み、前記コア成分は前記第1の流体内に分散していることを特徴とする、請求項11に記載のドロップオンデマンドの流体噴射装置を用いる方法。
- 前記滴を噴射することはさらに、前記第2の流体と混和しない第1の流体の滴を噴射することを含むことを特徴とする、請求項11に記載のドロップオンデマンドの流体噴射装置を用いる方法。
- 前記コア成分は生物活性剤を含むことを特徴とする、請求項11に記載のドロップオンデマンドの流体噴射装置を用いる方法。
- 前記滴を噴射することはさらに、前記コア成分とモノマーとを含む第1の流体の滴を、前記モノマーへの共反応体を含む第2の流体内に噴射することを含むことを特徴とする、請求項11に記載のドロップオンデマンドの流体噴射装置を用いる方法。
- 前記モノマーと前記共反応体とを反応させてポリマーの殻を形成し、前記コア成分をカプセル化することをさらに含むことを特徴とする、請求項17に記載のドロップオンデマンドの流体噴射装置を用いる方法。
- 前記マイクロカプセルを生成することはさらに、アルギン酸キトサンアルカリ金属のマイクロカプセルを生成することを含むことを特徴とする、請求項11に記載のドロップオンデマンドの流体噴射装置を用いる方法。
- 前記マイクロカプセルを生成することはさらに、コアセルベートを形成することを含むことを特徴とする、請求項11に記載のドロップオンデマンドの流体噴射装置を用いる方法。
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US10/765,402 US7578951B2 (en) | 2004-01-27 | 2004-01-27 | Method of making microcapsules utilizing a fluid ejector |
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008126459A (ja) * | 2006-11-20 | 2008-06-05 | Kanagawa Acad Of Sci & Technol | ゲルの製造方法及びそのための装置 |
JP2009523714A (ja) * | 2006-01-11 | 2009-06-25 | ペー・ウント・ヴェー・インヴェスト・フェアメーゲンス・フェアヴァルトゥングスゲゼルシャフト・エム・ベー・ハー | 封入された薬剤を放出するための被包膜、その製造方法、およびその使用方法 |
US8313702B2 (en) | 2009-07-16 | 2012-11-20 | Seiko Epson Corporation | Gel manufacturing apparatus |
JP2013525488A (ja) * | 2010-05-03 | 2013-06-20 | アプタリス ファーマ リミテッド | 消化酵素混合物を含有するパンクレアチンを含むマイクロペレット組成物 |
JP2019135296A (ja) * | 2019-02-19 | 2019-08-15 | 大日本印刷株式会社 | 固形薬剤の製造方法、インクジェット用インクセット |
CN114269813A (zh) * | 2020-06-01 | 2022-04-01 | 株式会社Lg化学 | 制备聚合物微粒的方法,聚合物微粒,使用其的医用组合物、美容组合物、医用制品和美容制品 |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7730746B1 (en) * | 2005-07-14 | 2010-06-08 | Imaging Systems Technology | Apparatus to prepare discrete hollow microsphere droplets |
KR100902781B1 (ko) * | 2007-10-05 | 2009-06-12 | (주)라이프코드 | 일체형 무균 캡슐 제조장치 |
CA2766202A1 (en) | 2009-06-29 | 2011-01-06 | Mcneil-Ppc, Inc. | Pharmaceutical tablet containing a liquid filled capsule |
FR2996466B1 (fr) * | 2012-10-09 | 2015-06-05 | Seppic Sa | Procede d'encapsulation par coacervation ne mettant pas en œuvre de reticulant toxique |
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US10093096B2 (en) | 2014-07-31 | 2018-10-09 | Hewlett-Packard Development Company, L.P. | Maintenance of a printhead of a printer |
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US11911731B2 (en) | 2016-10-21 | 2024-02-27 | Hewlett-Packard Development Company, L.P. | Droplet generator |
US10639607B2 (en) | 2017-06-16 | 2020-05-05 | Matralix Pte Ltd | Systems and methods for preparing wax and lipid particles |
CN111701545B (zh) * | 2020-06-04 | 2022-03-25 | 上海工程技术大学 | 一种适用于生产微胶囊型土壤调理剂的滴丸生产*** |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5211180A (en) * | 1975-07-17 | 1977-01-27 | New Japan Chem Co Ltd | Process of covering dispersed particles |
JPS5849433A (ja) * | 1981-09-18 | 1983-03-23 | Tanabe Seiyaku Co Ltd | マイクロカプセルの製法 |
JPS63236534A (ja) * | 1987-03-17 | 1988-10-03 | サウスウエスト・リサ−チ・インステイテユ−ト | シ−ムレスカプセルを大量生産する方法及び装置 |
JP2002507473A (ja) * | 1998-03-25 | 2002-03-12 | アヴェンティス・リサーチ・ウント・テクノロジーズ・ゲーエムベーハー・ウント・コー・カーゲー | マイクロカプセルの製造法 |
WO2003053325A2 (en) * | 2000-12-13 | 2003-07-03 | Purdue Research Foundation | Microencapsulation of drugs by solvent exchange |
JP2003200036A (ja) * | 2002-01-08 | 2003-07-15 | Kao Corp | 易崩壊性粒子製造システム |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3946398A (en) * | 1970-06-29 | 1976-03-23 | Silonics, Inc. | Method and apparatus for recording with writing fluids and drop projection means therefor |
US4548825A (en) * | 1978-11-15 | 1985-10-22 | Boehringer Ingelheim Gmbh | Method for ink-jet printing on uncoated tablets or uncoated tablet cores |
DE2849494A1 (de) * | 1978-11-15 | 1980-05-29 | Voss Gunter M | Verfahren zur herstellung von arzneimittel-formlingen |
US4692284A (en) * | 1986-04-30 | 1987-09-08 | Damon Biotech, Inc. | Method and apparatus for forming droplets and microcapsules |
US4877745A (en) * | 1986-11-17 | 1989-10-31 | Abbott Laboratories | Apparatus and process for reagent fluid dispensing and printing |
US5395620A (en) * | 1989-01-31 | 1995-03-07 | Coletica | Biodegradable microcapsules having walls composed of crosslinked atelocollagen and polyholoside |
US5260002A (en) * | 1991-12-23 | 1993-11-09 | Vanderbilt University | Method and apparatus for producing uniform polymeric spheres |
PT706352E (pt) * | 1993-06-29 | 2002-07-31 | Ponwell Entpr Ltd | Distribuidor |
JP3053325B2 (ja) * | 1993-12-20 | 2000-06-19 | 株式会社日立製作所 | 腐食電位のシミュレーション方法および原子炉プラントの運転監視装置 |
US6558633B1 (en) * | 1994-09-21 | 2003-05-06 | Isis Pharmaceuticals, Inc. | Chemical reaction apparatus and methods |
WO1996028247A1 (de) | 1995-03-15 | 1996-09-19 | Inotech Ag | Verkapselungsgerät |
DE19535010C2 (de) * | 1995-09-21 | 1998-01-22 | Pelikan Produktions Ag | Verwendung eines Tropfenerzeugers in einem medizinischen Gerät zum dosierten Zuführen eines Medikamentes zu einem Fluidstrom |
AU740493B2 (en) * | 1998-01-29 | 2001-11-08 | Kinerton Limited | Process for making absorbable microparticles |
AU2617099A (en) * | 1998-03-07 | 1999-09-20 | Inotech Ag | Method and device for capsulating microbial, plant and animal cells or biological and chemical substances |
US6474786B2 (en) * | 2000-02-24 | 2002-11-05 | The Board Of Trustees Of The Leland Stanford Junior University | Micromachined two-dimensional array droplet ejectors |
DE10024154A1 (de) | 2000-05-19 | 2001-11-22 | Inotech Encapsulation Ag Dotti | Verfahren und Vorrichtung zur Verkapselung von Zellen |
US6841593B2 (en) * | 2001-07-05 | 2005-01-11 | Baker Hughes Incorporated | Microencapsulated and macroencapsulated drag reducing agents |
US6641254B1 (en) * | 2002-04-12 | 2003-11-04 | Hewlett-Packard Development Company, L.P. | Electronic devices having an inorganic film |
-
2004
- 2004-01-27 US US10/765,402 patent/US7578951B2/en not_active Expired - Fee Related
- 2004-07-22 EP EP04017408.8A patent/EP1559476B1/en not_active Expired - Fee Related
- 2004-07-22 TW TW093121879A patent/TWI327467B/zh not_active IP Right Cessation
-
2005
- 2005-01-05 SG SG200500027A patent/SG113550A1/en unknown
- 2005-01-13 KR KR1020050003097A patent/KR101177782B1/ko active IP Right Grant
- 2005-01-25 JP JP2005016443A patent/JP4526399B2/ja not_active Expired - Fee Related
- 2005-01-26 CN CNA2005100063270A patent/CN1669628A/zh active Pending
- 2005-01-26 CA CA2494489A patent/CA2494489C/en not_active Expired - Fee Related
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5211180A (en) * | 1975-07-17 | 1977-01-27 | New Japan Chem Co Ltd | Process of covering dispersed particles |
JPS5849433A (ja) * | 1981-09-18 | 1983-03-23 | Tanabe Seiyaku Co Ltd | マイクロカプセルの製法 |
JPS63236534A (ja) * | 1987-03-17 | 1988-10-03 | サウスウエスト・リサ−チ・インステイテユ−ト | シ−ムレスカプセルを大量生産する方法及び装置 |
JP2002507473A (ja) * | 1998-03-25 | 2002-03-12 | アヴェンティス・リサーチ・ウント・テクノロジーズ・ゲーエムベーハー・ウント・コー・カーゲー | マイクロカプセルの製造法 |
WO2003053325A2 (en) * | 2000-12-13 | 2003-07-03 | Purdue Research Foundation | Microencapsulation of drugs by solvent exchange |
JP2003200036A (ja) * | 2002-01-08 | 2003-07-15 | Kao Corp | 易崩壊性粒子製造システム |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009523714A (ja) * | 2006-01-11 | 2009-06-25 | ペー・ウント・ヴェー・インヴェスト・フェアメーゲンス・フェアヴァルトゥングスゲゼルシャフト・エム・ベー・ハー | 封入された薬剤を放出するための被包膜、その製造方法、およびその使用方法 |
JP2008126459A (ja) * | 2006-11-20 | 2008-06-05 | Kanagawa Acad Of Sci & Technol | ゲルの製造方法及びそのための装置 |
US8313702B2 (en) | 2009-07-16 | 2012-11-20 | Seiko Epson Corporation | Gel manufacturing apparatus |
JP2013525488A (ja) * | 2010-05-03 | 2013-06-20 | アプタリス ファーマ リミテッド | 消化酵素混合物を含有するパンクレアチンを含むマイクロペレット組成物 |
JP2019135296A (ja) * | 2019-02-19 | 2019-08-15 | 大日本印刷株式会社 | 固形薬剤の製造方法、インクジェット用インクセット |
CN114269813A (zh) * | 2020-06-01 | 2022-04-01 | 株式会社Lg化学 | 制备聚合物微粒的方法,聚合物微粒,使用其的医用组合物、美容组合物、医用制品和美容制品 |
JP2022544815A (ja) * | 2020-06-01 | 2022-10-21 | エルジー・ケム・リミテッド | 高分子マイクロ粒子の製造方法、高分子マイクロ粒子、それを含む医療用組成物、美容組成物、医療用品および美容用品 |
CN114269813B (zh) * | 2020-06-01 | 2024-01-02 | 株式会社Lg化学 | 制备聚合物微粒的方法,聚合物微粒,使用其的医用组合物、美容组合物、医用制品和美容制品 |
JP7408217B2 (ja) | 2020-06-01 | 2024-01-05 | エルジー・ケム・リミテッド | 高分子マイクロ粒子の製造方法、高分子マイクロ粒子、それを含む医療用組成物、美容組成物、医療用品および美容用品 |
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SG113550A1 (en) | 2005-08-29 |
CA2494489A1 (en) | 2005-07-27 |
US7578951B2 (en) | 2009-08-25 |
JP4526399B2 (ja) | 2010-08-18 |
CA2494489C (en) | 2013-08-13 |
US20050161844A1 (en) | 2005-07-28 |
KR101177782B1 (ko) | 2012-08-30 |
CN1669628A (zh) | 2005-09-21 |
TW200524574A (en) | 2005-08-01 |
EP1559476A1 (en) | 2005-08-03 |
KR20050077260A (ko) | 2005-08-01 |
TWI327467B (en) | 2010-07-21 |
EP1559476B1 (en) | 2016-09-14 |
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