JP2005161062A - 骨移植組成物 - Google Patents
骨移植組成物 Download PDFInfo
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- JP2005161062A JP2005161062A JP2004355406A JP2004355406A JP2005161062A JP 2005161062 A JP2005161062 A JP 2005161062A JP 2004355406 A JP2004355406 A JP 2004355406A JP 2004355406 A JP2004355406 A JP 2004355406A JP 2005161062 A JP2005161062 A JP 2005161062A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3629—Intestinal tissue, e.g. small intestinal submucosa
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/365—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
- A61F2002/30677—Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Vascular Medicine (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Developmental Biology & Embryology (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
【解決手段】損傷した骨又は罹患した骨を修復誘導ために、粉末状の生分解性骨移植構成物の有効量を損傷又は罹患した領域に移植する工程を有し、前記骨移植構成物は脊椎動物の腸部の管腔部から剥離した粘膜下組織又はその消化物からなり、移植前に所定三次元形状に圧縮した粉末状とし、損傷した骨又は罹患した骨に移植する。
【選択図】なし
Description
脊椎動物の腸管の粘膜下組織及び基底部からなる小腸組織を組織切りばさみ、片刃かみそりの刃或いは他の適当な切断器具で任意の小片に切り刻む。得られた組織標本を丸底ステンレス鋼容器にいれ、液体窒素を容器に導入して組織標本を微粉砕用に凍結する。
微粉砕した腸の粘膜下組織からなる骨移植組成物は、酵素で消化することにより可溶化されほぼ均一な溶液を形成する。好ましい一態様においては、粉末状の微粉砕腸管粘膜下組織(実施例1と同様に生成した)は金網で容器にふるい入れ、再度浮遊させる。次にこの粉末を、塩酸でpHを2.5に調節した1mg/mlのペプシン(ミズーリ州、セントルイスのシグマ社)の0.1M酢酸溶液に入れ、48時間にわたり室温で消化した。反応溶媒は水酸化ナトリウムで中和し、ぺプシンの活動を不活性化した。可溶化した粘膜下組織は、次に溶液の塩析により濃縮し、分離してさらに精製及び/又は凍結乾燥し、粉末状のプロテアーゼ可溶化腸管粘膜下組織を生成した。
腸管粘膜下組織からなる2種類の骨移植組成物について、それらの骨組織の内因性成長の誘導を検討した。一方は自然の水和状態の粘膜下組織からなるもので、もう一方は乾燥凍結した粉末状の腸管粘膜下組織である。
Claims (4)
- 温血脊椎動物の骨の修復誘導方法であって、該方法は、前記脊椎動物の修復の必要な部位に生分解性骨移植構成物を有効量移植する工程からなり、前記骨移植構成物は基本的には、移植前に所定三次元形状に圧縮した粉末状の温血脊椎動物の腸管粘膜下組織又はその消化物からなり、前記の圧縮した粉末状の骨移植構成物は移植後その移植構成物が内因性組織に代わるまでその大体の形を維持することを特徴とする方法。
- 温血脊椎動物の骨の修復誘導方法であって、該方法は、前記脊椎動物の修復の必要な部位に生分解性骨移植構成物を有効量移植する工程からなり、前記骨移植構成物は基本的には、粉末状の温血脊椎動物の腸管粘膜下組織又はその消化物と生理学的適合性鉱物、成長因子、抗生物質、化学治療剤、抗原、抗体、酵素及びホルモンからなる群から選ばれる生物活性剤とからなり、前記粘膜下組織及び生物活性剤は移植前に所定三次元形状に圧縮し、前記の圧縮した粉末状の骨移植構成物は移植後その移植構成物が内因性組織に代わるまでその大体の形を維持することを特徴とする方法。
- 温血脊椎動物の骨の修復誘導に有用な生分解性骨移植構成物の生成における温血脊椎動物の腸粘膜下組織の使用であって、前記骨移植構成物は基本的には粉末状の温血脊椎動物の腸管粘膜下組織又はその消化物からなり、移植前に所定三次元形状に圧縮したもので、前記の圧縮した粉末状の骨移植構成物は移植後その移植構成物が内因性組織に代わるまでその大体の形を維持することを特徴とする使用。
- 温血脊椎動物の骨の修復誘導に有用な生分解性骨移植構成物の生成における温血脊椎動物の腸粘膜下組織の使用であり、前記骨移植構成物は基本的には粉末状の温血脊椎動物の腸管粘膜下組織又はその消化物と生理学的適合性鉱物、成長因子、抗生物質、化学治療剤、抗原、抗体、酵素及びホルモンからなる群から選ばれる生物活性剤とからなり、前記粘膜下組織及び生物活性剤は移植前に所定三次元形状に圧縮され、前記の圧縮された粉末状骨移植構成物は移植後その移植構成物が内因性組織に代わるまでその大体の形を維持することを特徴とする使用。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/386,432 US5641518A (en) | 1992-11-13 | 1995-02-10 | Method of repairing bone tissue |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP52447296A Division JP4020962B2 (ja) | 1995-02-10 | 1996-02-09 | 骨移植組成物 |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2005161062A true JP2005161062A (ja) | 2005-06-23 |
Family
ID=23525546
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52447296A Expired - Lifetime JP4020962B2 (ja) | 1995-02-10 | 1996-02-09 | 骨移植組成物 |
JP2004355406A Pending JP2005161062A (ja) | 1995-02-10 | 2004-12-08 | 骨移植組成物 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52447296A Expired - Lifetime JP4020962B2 (ja) | 1995-02-10 | 1996-02-09 | 骨移植組成物 |
Country Status (8)
Country | Link |
---|---|
US (1) | US5641518A (ja) |
EP (1) | EP0808167B1 (ja) |
JP (2) | JP4020962B2 (ja) |
AR (1) | AR000920A1 (ja) |
AU (1) | AU692063B2 (ja) |
CA (1) | CA2212647A1 (ja) |
DE (1) | DE69621595T2 (ja) |
WO (1) | WO1996024365A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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KR101229435B1 (ko) | 2010-08-16 | 2013-02-05 | 한스바이오메드 주식회사 | 바이러스 불활화된 골이식용 골분의 제조방법 |
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Also Published As
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CA2212647A1 (en) | 1996-08-15 |
JPH10513388A (ja) | 1998-12-22 |
AR000920A1 (es) | 1997-08-27 |
JP4020962B2 (ja) | 2007-12-12 |
EP0808167A4 (en) | 1998-06-10 |
US5641518A (en) | 1997-06-24 |
AU4778096A (en) | 1996-08-27 |
EP0808167A1 (en) | 1997-11-26 |
AU692063B2 (en) | 1998-05-28 |
DE69621595T2 (de) | 2003-01-16 |
DE69621595D1 (de) | 2002-07-11 |
EP0808167B1 (en) | 2002-06-05 |
WO1996024365A1 (en) | 1996-08-15 |
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