JP2005137558A - 心筋血流の定量化方法 - Google Patents
心筋血流の定量化方法 Download PDFInfo
- Publication number
- JP2005137558A JP2005137558A JP2003376921A JP2003376921A JP2005137558A JP 2005137558 A JP2005137558 A JP 2005137558A JP 2003376921 A JP2003376921 A JP 2003376921A JP 2003376921 A JP2003376921 A JP 2003376921A JP 2005137558 A JP2005137558 A JP 2005137558A
- Authority
- JP
- Japan
- Prior art keywords
- blood flow
- signal intensity
- magnetic resonance
- contrast agent
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/563—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution of moving material, e.g. flow contrast angiography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/563—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution of moving material, e.g. flow contrast angiography
- G01R33/56308—Characterization of motion or flow; Dynamic imaging
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Engineering & Computer Science (AREA)
- Signal Processing (AREA)
- High Energy & Nuclear Physics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
【解決手段】T1短縮効果を有する磁気共鳴造影剤を用いた心電図同期ファーストパス磁気共鳴イメージング(Gated First-Pass MRI)によって心筋血流を定量化する方法において、体動補正を行う手段と、関心領域(ROI)の処理を設定する手段と、前記磁気共鳴造影剤濃度の経時変化に対応する信号強度から入力及び出力曲線を作成する手段と、該入力曲線の信号強度飽和補正を行う手段と、該補正後の入力曲線と出力曲線から得られるパトラックプロットの直線部分の傾きK1を求める手段とを備える。
【選択図】なし
Description
Claims (6)
- T1短縮効果を有する磁気共鳴造影剤を用いた心電図同期ファーストパス磁気共鳴イメージング(Gated First-Pass MRI)によって心筋血流を定量化する方法において、体動補正を行う手段と、関心領域(ROI)の処理を設定する手段と、前記磁気共鳴造影剤濃度の経時変化に対応する信号強度から入力及び出力曲線を作成する手段と、該入力曲線の信号強度飽和補正を行う手段と、該補正後の入力曲線と出力曲線から得られるパトラックプロットの直線部分の傾きK1を求める手段と備えていることを特徴とする心筋血流の定量化方法。
- 前記磁気共鳴造影剤において、血液中の信号強度を測定する場合には、造影剤濃度が希薄濃度の磁気共鳴造影剤を用い、心筋組織中の信号強度を測定する場合には普通濃度の磁気共鳴造影剤を用いることを特徴とする請求項1に記載の心筋血流の定量化方法。
- 前記体動補正を行う手段が、左心室と右心室の接合点を設定し、該接合点が定点となるように処理画像を移動することを特徴とする請求項1又は2に記載の心筋血流の定量化方法。
- 前記磁気共鳴造影剤濃度の経時変化に対応する入力曲線の信号強度飽和補正を行う手段が、予め造影剤濃度−信号強度の関係(濃度信号曲線)に係る定量線を作成し、該曲線上で低濃度領域のデータを用いて最小二乗法による回帰直線を求め、該回帰直線を全濃度領域における造影剤濃度−信号強度の関係(信号強度飽和補正関数)とすることを特徴とする請求項1から3のいずれかに記載の心筋血流の定量化方法。
- 心筋の各セグメントにおいて前記K1値を求め、心尖部を中心に心基部を周辺に配置し、側壁から分割した角度毎に同心円状に該K1値を表示することを特徴とする請求項1から4のいずれかに記載の心筋血流の定量化方法。
- 更に、左心室心筋および左心室内腔における信号検出感度不均一を補正する手段を備えていることを特徴とする請求項1から5のいずれかに記載の心筋血流の定量化方法。
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003376921A JP4446049B2 (ja) | 2003-11-06 | 2003-11-06 | 心筋血流の定量化装置 |
PCT/JP2004/016192 WO2005044104A1 (ja) | 2003-11-06 | 2004-10-25 | 心筋血流の定量化方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003376921A JP4446049B2 (ja) | 2003-11-06 | 2003-11-06 | 心筋血流の定量化装置 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005137558A true JP2005137558A (ja) | 2005-06-02 |
JP4446049B2 JP4446049B2 (ja) | 2010-04-07 |
Family
ID=34567122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003376921A Expired - Fee Related JP4446049B2 (ja) | 2003-11-06 | 2003-11-06 | 心筋血流の定量化装置 |
Country Status (2)
Country | Link |
---|---|
JP (1) | JP4446049B2 (ja) |
WO (1) | WO2005044104A1 (ja) |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008220464A (ja) * | 2007-03-09 | 2008-09-25 | Toshiba Corp | X線ct装置および心筋パーフュージョン情報生成システム |
JP2009028511A (ja) * | 2007-06-28 | 2009-02-12 | Toshiba Corp | 画像処理装置、画像診断装置および画像処理方法 |
JP2009507545A (ja) * | 2005-09-13 | 2009-02-26 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | イメージングに対する多重造影剤注入 |
JP2009070272A (ja) * | 2007-09-14 | 2009-04-02 | Fujifilm Ri Pharma Co Ltd | 報告書作成プログラム、記録媒体および報告書作成方法 |
JP2009098131A (ja) * | 2007-09-25 | 2009-05-07 | Fujifilm Ri Pharma Co Ltd | 心臓核医学検査法による検査画像の解析装置及び方法 |
JP2010167082A (ja) * | 2009-01-22 | 2010-08-05 | Toshiba Corp | 画像処理装置 |
CN102068269A (zh) * | 2011-01-21 | 2011-05-25 | 南京信息工程大学 | 用于人体器官局部血流的无损伤定量测定方法 |
JP2012055508A (ja) * | 2010-09-09 | 2012-03-22 | Hitachi Medical Corp | 磁気共鳴イメージング装置及び画像補正方法 |
EP2613167A1 (en) * | 2012-01-04 | 2013-07-10 | Samsung Medison Co., Ltd. | Diagnostic imaging apparatus and method of operating the same |
WO2014042275A1 (ja) * | 2012-09-14 | 2014-03-20 | 株式会社東芝 | 磁気共鳴イメージング装置 |
JP2014190695A (ja) * | 2013-03-26 | 2014-10-06 | Ehime Univ | 3次元ダイナミック心筋核医学画像データのパトラック解析 |
JP2014208286A (ja) * | 2009-09-18 | 2014-11-06 | 株式会社東芝 | 磁気共鳴イメージング装置 |
JP2016531630A (ja) * | 2013-10-01 | 2016-10-13 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 心筋灌流の病理学的特性評価のためのシステム及び方法 |
US10295638B2 (en) | 2007-06-28 | 2019-05-21 | Toshiba Medical Systems Corporation | Image processing apparatus, image diagnostic apparatus and image processing method |
JP2019207183A (ja) * | 2018-05-30 | 2019-12-05 | 日本メジフィジックス株式会社 | 信号処理プログラム、信号処理方法及び信号処理装置 |
JP2020142096A (ja) * | 2010-08-12 | 2020-09-10 | ハートフロー, インコーポレイテッド | 患者固有の血流のモデリングのための方法およびシステム |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5558672B2 (ja) * | 2008-03-19 | 2014-07-23 | 株式会社東芝 | 画像処理装置及びx線コンピュータ断層撮影装置 |
JP7481264B2 (ja) * | 2018-05-17 | 2024-05-10 | ロンドン ヘルス サイエンシーズ センター リサーチ インコーポレイテッド | 動的血管造影画像化 |
CN116429870A (zh) * | 2022-09-30 | 2023-07-14 | 上海立迪生物技术股份有限公司 | 一种消除成像质谱流式灵敏度差异的方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6205349B1 (en) * | 1998-09-29 | 2001-03-20 | Siemens Medical Systems, Inc. | Differentiating normal living myocardial tissue, injured living myocardial tissue, and infarcted myocardial tissue in vivo using magnetic resonance imaging |
US6526307B2 (en) * | 2000-12-29 | 2003-02-25 | Ge Medical Systems Global Technology Co., Llc | Method and apparatus to improve myocardial infarction detection with blood pool signal suppression |
JP4112368B2 (ja) * | 2001-02-13 | 2008-07-02 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 連続したデータセットの分析 |
-
2003
- 2003-11-06 JP JP2003376921A patent/JP4446049B2/ja not_active Expired - Fee Related
-
2004
- 2004-10-25 WO PCT/JP2004/016192 patent/WO2005044104A1/ja active Application Filing
Cited By (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009507545A (ja) * | 2005-09-13 | 2009-02-26 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | イメージングに対する多重造影剤注入 |
US10154797B2 (en) | 2005-09-13 | 2018-12-18 | Koninklijke Philips N.V. | Multiple contrast agent injection for imaging |
JP2008220464A (ja) * | 2007-03-09 | 2008-09-25 | Toshiba Corp | X線ct装置および心筋パーフュージョン情報生成システム |
US10295638B2 (en) | 2007-06-28 | 2019-05-21 | Toshiba Medical Systems Corporation | Image processing apparatus, image diagnostic apparatus and image processing method |
JP2009028511A (ja) * | 2007-06-28 | 2009-02-12 | Toshiba Corp | 画像処理装置、画像診断装置および画像処理方法 |
JP2009070272A (ja) * | 2007-09-14 | 2009-04-02 | Fujifilm Ri Pharma Co Ltd | 報告書作成プログラム、記録媒体および報告書作成方法 |
JP2009098131A (ja) * | 2007-09-25 | 2009-05-07 | Fujifilm Ri Pharma Co Ltd | 心臓核医学検査法による検査画像の解析装置及び方法 |
JP2010167082A (ja) * | 2009-01-22 | 2010-08-05 | Toshiba Corp | 画像処理装置 |
US9795352B2 (en) | 2009-01-22 | 2017-10-24 | Toshiba Medical Systems Corporation | Image processing apparatus and X-ray diagnostic apparatus |
JP2014208286A (ja) * | 2009-09-18 | 2014-11-06 | 株式会社東芝 | 磁気共鳴イメージング装置 |
US9839366B2 (en) | 2009-09-18 | 2017-12-12 | Toshiba Medical Systems Corporation | Magnetic resonance imaging apparatus and magnetic resonance imaging method |
US10058257B2 (en) | 2009-09-18 | 2018-08-28 | Toshiba Medical Systems Corporation | Magnetic resonance imaging apparatus and magnetic resonance imaging method |
US9474455B2 (en) | 2009-09-18 | 2016-10-25 | Toshiba Medical Systems Corporation | Magnetic resonance imaging apparatus and magnetic resonance imaging method |
US9585576B2 (en) | 2009-09-18 | 2017-03-07 | Toshiba Medical Systems Corporation | Magnetic resonance imaging apparatus and magnetic resonance imaging method |
US11583340B2 (en) | 2010-08-12 | 2023-02-21 | Heartflow, Inc. | Method and system for image processing to determine blood flow |
JP2020142096A (ja) * | 2010-08-12 | 2020-09-10 | ハートフロー, インコーポレイテッド | 患者固有の血流のモデリングのための方法およびシステム |
US11793575B2 (en) | 2010-08-12 | 2023-10-24 | Heartflow, Inc. | Method and system for image processing to determine blood flow |
US12016635B2 (en) | 2010-08-12 | 2024-06-25 | Heartflow, Inc. | Method and system for image processing to determine blood flow |
US12029494B2 (en) | 2010-08-12 | 2024-07-09 | Heartflow, Inc. | Method and system for image processing to determine blood flow |
JP2012055508A (ja) * | 2010-09-09 | 2012-03-22 | Hitachi Medical Corp | 磁気共鳴イメージング装置及び画像補正方法 |
CN102068269A (zh) * | 2011-01-21 | 2011-05-25 | 南京信息工程大学 | 用于人体器官局部血流的无损伤定量测定方法 |
US9398857B2 (en) | 2012-01-04 | 2016-07-26 | Samsung Medison Co., Ltd. | Diagnostic imaging apparatus and method of operating the same |
KR101501515B1 (ko) * | 2012-01-04 | 2015-03-11 | 삼성메디슨 주식회사 | 진단 영상 장치 및 그 동작 방법 |
EP2613167A1 (en) * | 2012-01-04 | 2013-07-10 | Samsung Medison Co., Ltd. | Diagnostic imaging apparatus and method of operating the same |
US10368777B2 (en) | 2012-09-14 | 2019-08-06 | Toshiba Medical Systems Corporation | Non-contrast dynamic MRI myocardial perfusion analysis and visualization |
JP2014057862A (ja) * | 2012-09-14 | 2014-04-03 | Toshiba Corp | 磁気共鳴イメージング装置 |
WO2014042275A1 (ja) * | 2012-09-14 | 2014-03-20 | 株式会社東芝 | 磁気共鳴イメージング装置 |
JP2014190695A (ja) * | 2013-03-26 | 2014-10-06 | Ehime Univ | 3次元ダイナミック心筋核医学画像データのパトラック解析 |
JP2016531630A (ja) * | 2013-10-01 | 2016-10-13 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 心筋灌流の病理学的特性評価のためのシステム及び方法 |
JP2019207183A (ja) * | 2018-05-30 | 2019-12-05 | 日本メジフィジックス株式会社 | 信号処理プログラム、信号処理方法及び信号処理装置 |
JP7066526B2 (ja) | 2018-05-30 | 2022-05-13 | 日本メジフィジックス株式会社 | 信号処理プログラム、信号処理方法及び信号処理装置 |
Also Published As
Publication number | Publication date |
---|---|
WO2005044104A1 (ja) | 2005-05-19 |
JP4446049B2 (ja) | 2010-04-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP4446049B2 (ja) | 心筋血流の定量化装置 | |
US20210106237A1 (en) | Method and system for image processing of intravascular hemodynamics | |
CA2555373C (en) | Tissue evaluation using global tissue characteristics of non-invasive imaging and systems for determining global tissue characteristics of images | |
Nikolaou et al. | MRI and CT in the diagnosis of coronary artery disease: indications and applications | |
Rischpler et al. | PET/MRI of the heart | |
Festa et al. | Magnetic resonance imaging is the diagnostic tool of choice in the preoperative evaluation of patients with partial anomalous pulmonary venous return | |
EP2271257B1 (en) | Imaging technique | |
US9232907B2 (en) | System, method and computer-accessible medium for utilizing cardiac output to improve measurement of tracer input function in dynamic contrast-enhanced magnetic resonance imaging | |
US20210239863A1 (en) | Super resolution in positron emission tomography imaging using ultrafast ultrasound imaging | |
Gensler et al. | Myocardial T1: quantification by using an ECG-triggered radial single-shot inversion-recovery MR imaging sequence | |
EP2838430B1 (en) | Perfusion imaging | |
US20180185519A1 (en) | Assessment of coronary heart disease with carbon dioxide | |
Timmer et al. | Potential of [11C] acetate for measuring myocardial blood flow: Studies in normal subjects and patients with hypertrophic cardiomyopathy | |
Li et al. | Myocardial perfusion imaging by cardiovascular magnetic resonance: research progress and current implementation | |
Aquaro et al. | Cardiac metabolism in a pig model of ischemia–reperfusion by cardiac magnetic resonance with hyperpolarized 13C-Pyruvate | |
Krombach et al. | Characterization of myocardial viability using MR and CT imaging | |
Blanken et al. | Coronary flow assessment using accelerated 4D flow MRI with respiratory motion correction | |
McCommis et al. | Feasibility study of myocardial perfusion and oxygenation by noncontrast MRI: comparison with PET study in a canine model | |
Kikuchi et al. | Assessment of coronary flow velocity reserve in the left main trunk using phase-contrast MR imaging at 3T: Comparison with 15O-labeled water positron emission tomography | |
Takahashi et al. | MR microscopy of the lung in small rodents | |
Yun et al. | Multiparametric myocardial mapping using cardiac magnetic resonance imaging in healthy dogs: Reproducibility, repeatability, and differences across slices, segments, and sequences | |
O'Regan et al. | Establishing a clinical cardiac MRI service | |
KR101576873B1 (ko) | 선택적 관상동맥 컴퓨터 단층촬영 혈관조영을 통한 심근홍조등급 분류방법 | |
Biglands | Quanitifying myocardial blood flow using dynamic contrast enhanced cardiac magnetic resonance imaging | |
Ginami | Respiratory Motion Compensation in Coronary Magnetic Resonance Angiography: Analysis and Optimization of Self-Navigation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20061012 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090825 |
|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090929 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20091208 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20091210 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130129 Year of fee payment: 3 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 4446049 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20160129 Year of fee payment: 6 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
LAPS | Cancellation because of no payment of annual fees |