JP2005002041A - Water-soluble pearl powder - Google Patents
Water-soluble pearl powder Download PDFInfo
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- JP2005002041A JP2005002041A JP2003166904A JP2003166904A JP2005002041A JP 2005002041 A JP2005002041 A JP 2005002041A JP 2003166904 A JP2003166904 A JP 2003166904A JP 2003166904 A JP2003166904 A JP 2003166904A JP 2005002041 A JP2005002041 A JP 2005002041A
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- pearl powder
- water
- soluble
- calcium lactate
- soluble pearl
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Abstract
Description
【０００１】
【発明の属する技術分野】
本発明は、乳酸カルシウムを含むことを特徴とする、水溶性真珠粉及びその製造方法に関する。
【０００２】
また、本発明は、下記工程：
真珠を洗浄し、乾燥させ、粉砕し真珠粉を得る工程、
得られた真珠粉に乳酸を加え、乳酸カルシウム溶液を得る工程、
得られた真珠粉にタンパク質分解酵素を加え、タンパク質分解物を得る工程
得られたタンパク質分解物を乳酸カルシウムに加える工程
を含むことを特徴とする、
乳酸カルシウムを含む水溶性真珠粉の製造方法に関する。
【０００３】
【従来の技術】
真珠は、中国伝統の薬剤として、代代の皇帝や貴族の間で珍重されてきたことが知られている。明の時代の薬物書である「本草綱目」にも、真珠粉のことが詳しく紹介されており、精神安定、目のかすみをとる、顔に塗れば血色をよくする、手足に塗れば皮膚荒れ湿疹をとる等の効果が記載されている。
現代科学の解明により、真珠粉は、皮膚のコラーゲンの増加、メラニン色素の増加抑制、細胞の老化防止及び乾燥によるシワの防止の効果を有することが解明されてきた。
しかし、一般的な真珠粉は、真珠をそのまま粉砕したものであり、人体への吸収率も１０〜２０％程度とされており、人体への吸収がより高い真珠粉の開発が待たれていた。
【０００４】
本発明者は、鋭意研究を行った結果、乳酸を加えることによってカルシウムを分離し、酵素でおだやかに真珠タンパク質を分解し、得られたタンパク質分解物を乳酸カルシウムに加えることによって、人体への吸収率が高く、栄養成分が豊富な水溶性真珠粉を得ることができることを発見し、本発明を完成させた。
【０００５】
【発明が解決しようとする課題】
本発明は、乳酸カルシウムを含むことを特徴とする、水溶性真珠粉及びその製造方法を提供することを目的とする。
【０００６】
【課題を解決するための手段】
本発明は、乳酸カルシウムを含むことを特徴とする、水溶性真珠粉に関する。
本発明の水溶性真珠粉の製造方法は、下記工程：
真珠を洗浄し、乾燥させ、粉砕し真珠粉を得る工程、
得られた真珠粉に乳酸を加え、乳酸カルシウム溶液を得る工程、
得られた真珠粉にタンパク質分解酵素を加え、タンパク質分解物を得る工程
得られたタンパク質分解物を乳酸カルシウムに加える工程
を含む。
【０００７】
下記において、本発明の製造方法をより具体的に説明する。
真珠は、淡水真珠及び海水真珠を用いることができる。海水真珠は核として貝殻を用いるが、淡水真珠は、貝殻ではなく貝肉を用いている。核として用いられた貝肉は真珠層に吸収され、そのまま粉砕しても貝殻分が混入しないことから、好ましくは、淡水真珠が用いられる。選別は、目視で行い、形の良い真珠は、宝飾品として用いられ、それ以外の真珠を本発明に用いることができる。
【０００８】
真珠を蒸留水で洗浄し、塵や泥を取り除く。次に、洗浄された真珠を乾燥機に入れ、乾燥する。乾燥温度は、５０〜１５０℃、好ましくは、８０〜１２０℃、より好ましくは、１００℃で行うことができる。乾燥時間は、真珠の量によって異なるが、例えば、１００℃、８時間で約５０ｋｇの真珠を乾燥することができる。
乾燥した真珠を、粉砕機に入れ、細かく粉砕する。粉砕は、常温で行うことができる。１時間当たりの真珠粉砕量は、約５ｋｇであり、粉砕された真珠の直径は、約１５０μｍである。
粉砕された真珠に乳酸を加え（例えば、乳酸濃度２０％、温度６０℃で１時間に約５ｋｇを生産することができる）、不溶性真珠カルシウム（炭酸カルシウム）を水溶性乳酸カルシウムに変化させ、乳酸カルシウム水溶液を得る。これによって、カルシウムの人体への吸収率を高くすることができる。
得られたタンパク質をタンパク質分解酵素によってアミノ酸レベルまで分解する。
得られたアミノ酸を乳酸カルシウム水溶液に加え、結晶させ、乾燥し、これを粉砕し、本発明の真珠粉を得る。
【０００９】
本発明の水溶性真珠粉は、（１）美容効果、（２）女性生理機能改善効果及び（３）睡眠改善効果を有する。
【００１０】
（１）美容効果としては、皮膚の角質層への保水効果、血液浄化作用と血液粘度低下、血中脂肪を低減し、血液循環を改善することによる皮膚の老化防止効果、及び消化機能を調節し、老廃物を排出することによるニキビ、湿疹等の予防効果が挙げられる。
【００１１】
（２）女性生理機能改善効果としては、体内の生理機能調節作用により初潮期の少女と女性生理時障害の改善、すなわち、下記の症状に対する補助治療効果が認められる。
・生理不順
・出血量のばらつき
・生理期間が長い
・腰痛
・めまい
・集中力低下
・更年期障害
【００１２】
（３）睡眠改善効果としては、精神を安定させ、ストレスを改善し、眠りを深くする等の効果を有する。
本発明の水溶性真珠粉は、朝晩各一回、０．３〜０．５ｇを水又はお湯に溶かして飲むことができる。また、蜂蜜や牛乳等に混ぜて飲むこともできる。
また、本発明の水溶性真珠粉は、外用として、洗面後に、水溶液を顔につけて軽くマッサージすることもできる。この場合、蒸気又は蒸しタオルを併用するとより効果的である。卵白や牛乳に混ぜて、朝晩のパックに利用することもできる。湿疹、あせも、アトピーには、水溶液を直接適用するか、又はフェイスクリームなどに混ぜて適用することができる。
【００１３】
【実施例】
以下、本発明を実施例により詳細に説明をするが、これらに制限されるものではない。
１．真珠粉の製造
上記の製造方法にしたがって、養殖した淡水真珠を用いて水溶性真珠粉を製造した。養殖池の水は、中国太湖より引かれていた。真珠を目視で選別し、形の良いものを宝飾品とし、それ以外のものを本発明の水溶性真珠粉の製造に用いた。
【００１４】
２．真珠粉の分析値
本発明の水溶性真珠粉末の組成を分析したところ下記の値を得た。
項目 検出値
タンパク質 １．８％
ｐＨ ４．５〜６．５
鉄 ２１．７ｍｇ／ｋｇ
亜鉛 ４．６ｍｇ／ｋｇ
カルシウム １６．６ｇ／１００ｇ
マグネシウム ０．５ｇ／１００ｇ
セレニウム ＜０．３μｇ／１００ｇ
マンガン ２０８．７ｍｇ／ｋｇ
ナマリ ０．５ｍｇ／ｋｇ
砒素 ＜０．２ｍｇ・ｋｇ
一般生菌数 ＜１０ｃｆｕ／ｇ
大腸菌群 ＜３ＭＰＮ／１００ｇ
病原菌 検出せず
また、本発明の水溶性真珠粉末のアミノ酸組成を分析したところ下記の値を得た。
項目 検出値（％）
水溶性アミノ酸合計 １．１９
アスパラギン酸 検出せず
スレオニン ０．０６
セリン ０．０４
グルタミン酸 ０．２４
グリシン ０．２９
アラニン ０．１３
バリン ０．０４
メチオニン ０．０１
イソロイシン ０．０１
リシン ０．０３
チロシン ０．０１
フェニルアラアラニン ０．０２
ヒスチジン ０．０１
ロイシン ０．０４
ＮＨ３ ０．０１
アルギニン ０．０８
シスチン ０．０２
プロリン ０．１５
【００１５】
３．毒性試験結果
実験用ラット（体重１８〜２２ｇ、雌雄各５匹／群）に水溶性真珠粉を経口で１回投与し、２週間の急性毒性レベルを測定した。
本発明の水溶性真珠粉（乳白色）を蒸留水に溶解し、１０００，２１５０，４６４０，１００００ｍｇ／ｋｇの用量でラットに投与した。投与量は，０．１ｍｌ／１０ｇ体重とした。投与後、ラットの一般状態、中毒状態、死亡状態を２週間観察した。Ｈｏｒｎ’ｓ法に基づき、ＬＤ５０値を求めた。
その結果、いずれの群においても、死亡例は、認められなかった。また、一般状態への影響や中毒症状も認められなかった。
したがって、本発明の水溶性真珠粉のラットに対する最大１００００ｍｇ／ｋｇ体重のＬＤ５０値は、急性毒性レベル基準によると「無毒」に属する。[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a water-soluble pearl powder containing calcium lactate and a method for producing the same.
[0002]
The present invention also includes the following steps:
Washing pearls, drying, crushing to obtain pearl powder,
Adding lactic acid to the obtained pearl powder to obtain a calcium lactate solution,
A step of adding a proteolytic enzyme to the obtained pearl powder to obtain a proteolytic product includes a step of adding the proteolytic product obtained to calcium lactate,
The present invention relates to a method for producing a water-soluble pearl powder containing calcium lactate.
[0003]
[Prior art]
It is known that pearls have been prized as a traditional Chinese medicine among the generations of emperors and aristocrats. The “Hakuso Tuname”, a drug book of the Ming Dynasty, also introduces pearl powder in detail. It stabilizes the skin, removes blurring of the eyes, improves the color when applied to the face, and rough skin when applied to the limbs. Effects such as taking eczema are described.
Through the elucidation of modern science, it has been elucidated that pearl powder has an effect of increasing skin collagen, suppressing increase of melanin pigment, preventing aging of cells and preventing wrinkles by drying.
However, general pearl powder is obtained by pulverizing pearls as they are, and the absorption rate to the human body is about 10 to 20%, and the development of pearl powder with higher absorption to the human body has been awaited. .
[0004]
As a result of diligent research, the present inventor has separated calcium by adding lactic acid, gently decomposes pearl protein with an enzyme, and adds the obtained proteolysate to calcium lactate to absorb it into the human body. It was discovered that a water-soluble pearl powder having a high rate and rich in nutritional components can be obtained, and the present invention has been completed.
[0005]
[Problems to be solved by the invention]
It is an object of the present invention to provide a water-soluble pearl powder containing calcium lactate and a method for producing the same.
[0006]
[Means for Solving the Problems]
The present invention relates to a water-soluble pearl powder containing calcium lactate.
The method for producing the water-soluble pearl powder of the present invention includes the following steps:
Washing pearls, drying, crushing to obtain pearl powder,
Adding lactic acid to the obtained pearl powder to obtain a calcium lactate solution,
A step of adding a proteolytic enzyme to the obtained pearl powder to obtain a protein degradation product includes a step of adding the obtained protein degradation product to calcium lactate.
[0007]
Below, the manufacturing method of this invention is demonstrated more concretely.
As the pearl, a freshwater pearl and a seawater pearl can be used. Seawater pearls use shells as the core, but freshwater pearls use shellfish instead of shells. Since the shellfish used as the core is absorbed by the pearl layer and the shell is not mixed even if crushed as it is, freshwater pearls are preferably used. Sorting is performed visually, and pearls with good shape are used as jewelry, and other pearls can be used in the present invention.
[0008]
Wash pearls with distilled water to remove dust and mud. Next, the washed pearl is put into a dryer and dried. The drying temperature can be 50 to 150 ° C, preferably 80 to 120 ° C, more preferably 100 ° C. The drying time varies depending on the amount of pearls. For example, about 50 kg of pearls can be dried at 100 ° C. for 8 hours.
The dried pearl is put into a pulverizer and pulverized finely. The pulverization can be performed at room temperature. The amount of pearls crushed per hour is about 5 kg, and the diameter of the crushed pearls is about 150 μm.
Lactic acid is added to the crushed pearl (for example, about 5 kg can be produced at an lactic acid concentration of 20% and a temperature of 60 ° C. per hour), and insoluble pearl calcium (calcium carbonate) is changed to water-soluble calcium lactate, An aqueous calcium solution is obtained. Thereby, the absorption rate of calcium into the human body can be increased.
The resulting protein is degraded to the amino acid level by proteolytic enzymes.
The obtained amino acid is added to an aqueous calcium lactate solution, crystallized, dried, and pulverized to obtain the pearl powder of the present invention.
[0009]
The water-soluble pearl powder of the present invention has (1) a cosmetic effect, (2) a female physiological function improving effect, and (3) a sleep improving effect.
[0010]
(1) Cosmetic effects include water retention effect on the skin's stratum corneum, blood purification and blood viscosity reduction, blood fat reduction, blood circulation improvement and skin digestion prevention effect, and regulation of digestive function In addition, the prevention of acne, eczema and the like by discharging waste products.
[0011]
(2) As a female physiological function improvement effect, improvement of menstrual disorders and female physiological disorders by the physiological function regulating action in the body, that is, an auxiliary treatment effect for the following symptoms is recognized.
・ Failure of menstruation ・ Dispersion of bleeding amount ・ Long periods of menstruation ・ Low back pain ・ Dizziness ・ Low concentration ・ Menopause [0012]
(3) The sleep improvement effect has effects such as stabilizing the mind, improving stress, and deepening sleep.
The water-soluble pearl powder of the present invention can be taken by dissolving 0.3 to 0.5 g in water or hot water once each morning and night. It can also be mixed with honey or milk.
Moreover, the water-soluble pearl powder of the present invention can be lightly massaged by applying an aqueous solution to the face after washing the face for external use. In this case, it is more effective to use steam or steam towel together. It can be mixed with egg white or milk and used for morning and evening packs. For eczema, ash, and atopy, an aqueous solution can be applied directly or mixed with face cream or the like.
[0013]
【Example】
EXAMPLES Hereinafter, although an Example demonstrates this invention in detail, it is not restrict | limited to these.
1. Manufacture of pearl powder According to said manufacturing method, the water-soluble pearl powder was manufactured using the cultured freshwater pearl. The water in the aquaculture pond was drawn from Taihu Lake, China. The pearls were visually selected, and those having good shapes were used as jewelry, and the others were used for producing the water-soluble pearl powder of the present invention.
[0014]
2. Analysis value of pearl powder The composition of the water-soluble pearl powder of the present invention was analyzed and the following values were obtained.
Item Detection value Protein 1.8%
pH 4.5-6.5
Iron 21.7mg / kg
Zinc 4.6mg / kg
Calcium 16.6g / 100g
Magnesium 0.5g / 100g
Selenium <0.3μg / 100g
Manganese 208.7mg / kg
Namari 0.5mg / kg
Arsenic <0.2mg ・ kg
General viable count <10 cfu / g
Coliforms <3MPN / 100g
The pathogen was not detected, and the amino acid composition of the water-soluble pearl powder of the present invention was analyzed, and the following values were obtained.
Item Detection value (%)
Water-soluble amino acids total 1.19
Aspartic acid not detected Threonine 0.06
Serine 0.04
Glutamic acid 0.24
Glycine 0.29
Alanine 0.13
Valine 0.04
Methionine 0.01
Isoleucine 0.01
Lysine 0.03
Tyrosine 0.01
Phenylaraalanine 0.02
Histidine 0.01
Leucine 0.04
NH 3 0.01
Arginine 0.08
Cystine 0.02
Proline 0.15
[0015]
3. Toxicity test results The water-soluble pearl powder was orally administered once to experimental rats (body weight 18 to 22 g, 5 males and 5 females / group), and the acute toxicity level for 2 weeks was measured.
The water-soluble pearl powder (milky white) of the present invention was dissolved in distilled water and administered to rats at doses of 1000, 2150, 4640, and 10000 mg / kg. The dose was 0.1 ml / 10 g body weight. After administration, the rats were observed for general condition, poisoning, and death for 2 weeks. Based on Horn's method, LD 50 value was obtained.
As a result, there were no deaths in any group. In addition, there were no effects on general condition or toxic symptoms.
Therefore, the LD 50 value of up to 10,000 mg / kg body weight for rats of the water-soluble pearl powder of the present invention belongs to “non-toxic” according to the acute toxicity level criteria.
Claims (2)
真珠を洗浄し、乾燥させ、粉砕し真珠粉を得る工程、
得られた真珠粉に乳酸を加え、乳酸カルシウム溶液を得る工程、
得られた真珠粉にタンパク質分解酵素を加え、タンパク質分解物を得る工程
得られたタンパク質分解物を乳酸カルシウムに加える工程
を含むことを特徴とする、
乳酸カルシウムを含む水溶性真珠粉の製造方法。The following process:
Washing pearls, drying, crushing to obtain pearl powder,
Adding lactic acid to the obtained pearl powder to obtain a calcium lactate solution,
A step of adding a proteolytic enzyme to the obtained pearl powder to obtain a proteolytic product includes a step of adding the proteolytic product obtained to calcium lactate,
A method for producing water-soluble pearl powder containing calcium lactate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003166904A JP2005002041A (en) | 2003-06-11 | 2003-06-11 | Water-soluble pearl powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003166904A JP2005002041A (en) | 2003-06-11 | 2003-06-11 | Water-soluble pearl powder |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2005002041A true JP2005002041A (en) | 2005-01-06 |
Family
ID=34092913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003166904A Pending JP2005002041A (en) | 2003-06-11 | 2003-06-11 | Water-soluble pearl powder |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2005002041A (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014051440A (en) * | 2012-09-05 | 2014-03-20 | Mikimoto Pharmaceut Co Ltd | Metallothionein production accelerator and antioxidant |
| JP5760280B1 (en) * | 2014-05-12 | 2015-08-05 | 株式会社東洋新薬 | Effervescent skin external preparation |
| JP2017513923A (en) * | 2014-03-14 | 2017-06-01 | 欧詩漫生物股▲ふん▼有限公司Ｏｓｍｕｎ Ｂｉｏｌｏｇｉｃａｌ Ｃｏ．， Ｌｔｄ | Method for separating and producing pearl extract from a kind of pearl |
| CN107495336A (en) * | 2017-08-01 | 2017-12-22 | 苏州太湖美药业有限公司 | A kind of preparation method of soluble pearl powder |
| JP2018507904A (en) * | 2015-03-17 | 2018-03-22 | 欧詩漫生物股▲ふん▼有限公司Ｏｓｍ Ｂｉｏｌｏｇｙ Ｃｏ．， Ｌｔｄ． | A kind of cosmetic composition used for skin whitening and its preparation method |
| CN113049729A (en) * | 2021-03-10 | 2021-06-29 | 广西中医药大学 | Control method for pearl quality standard in pearl compound preparation |
| CN113663566A (en) * | 2021-08-23 | 2021-11-19 | 亳州市永刚饮片厂有限公司 | Pearl powder production process |
| CN115282168A (en) * | 2022-08-30 | 2022-11-04 | 马应龙大健康有限公司 | Soothing moisturizer for relieving infantile eczema symptom and preparation method and application thereof |
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| JPS6041613A (en) * | 1983-08-12 | 1985-03-05 | Shigeo Yamamoto | Pearl extract having high absorbability and its production |
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