JP2003527090A - 新規なインターフェロンベータ様分子 - Google Patents

新規なインターフェロンベータ様分子

Info

Publication number
JP2003527090A
JP2003527090A JP2001520147A JP2001520147A JP2003527090A JP 2003527090 A JP2003527090 A JP 2003527090A JP 2001520147 A JP2001520147 A JP 2001520147A JP 2001520147 A JP2001520147 A JP 2001520147A JP 2003527090 A JP2003527090 A JP 2003527090A
Authority
JP
Japan
Prior art keywords
polypeptide
interferon
conjugate
amino acid
moiety
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001520147A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003527090A5 (fr
Inventor
ぺダーセン，アンデルス・ヒェルホルト
シャンビエ，ハンス・タルスガールド
アンデルセン，キム・ヴィルブール
ボルネス，クラウス
ラスムッセン，ポウル・バード
Original Assignee
マキシゲン・エイピーエス
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by マキシゲン・エイピーエス filed Critical マキシゲン・エイピーエス
Publication of JP2003527090A publication Critical patent/JP2003527090A/ja
Publication of JP2003527090A5 publication Critical patent/JP2003527090A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2001520147A 1999-08-27 2000-08-25 新規なインターフェロンベータ様分子 Pending JP2003527090A (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
DKPA199901197 1999-08-27
DK199901197 1999-08-27
US16078299P 1999-10-21 1999-10-21
US60/160,782 1999-10-21
DK199901691 1999-11-26
DKPA199901691 1999-11-26
DKPA200000194 2000-02-07
DK200000194 2000-02-07
DKPA200000363 2000-03-07
DK200000363 2000-03-07
DKPA200000642 2000-04-14
DK200000642 2000-04-14
PCT/DK2000/000471 WO2001015736A2 (fr) 1999-08-27 2000-08-25 Nouvelles molecules analogues a l'interferon beta

Publications (2)

Publication Number Publication Date
JP2003527090A true JP2003527090A (ja) 2003-09-16
JP2003527090A5 JP2003527090A5 (fr) 2007-10-11

Family

ID=27545189

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001520147A Pending JP2003527090A (ja) 1999-08-27 2000-08-25 新規なインターフェロンベータ様分子

Country Status (14)

Country Link
EP (1) EP1328295A2 (fr)
JP (1) JP2003527090A (fr)
KR (1) KR20020034181A (fr)
CN (1) CN1501815A (fr)
AU (1) AU6687000A (fr)
BR (1) BR0013638A (fr)
CA (1) CA2380760A1 (fr)
CZ (1) CZ2002521A3 (fr)
HU (1) HUP0302674A2 (fr)
IL (1) IL147581A0 (fr)
MX (1) MXPA02001969A (fr)
NO (1) NO20020929L (fr)
SK (1) SK2942002A3 (fr)
WO (1) WO2001015736A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008524296A (ja) * 2004-12-22 2008-07-10 エフ．ホフマン−ラ ロシュ アーゲー インスリン様増殖因子−１とポリ（エチレングリコール）のコンジュゲート
JP2010536788A (ja) * 2007-08-16 2010-12-02 ファーマエッセンティア コーポレイション タンパク質−高分子結合体
US11559567B2 (en) 2014-11-06 2023-01-24 Pharmaessentia Corporation Dosage regimen for pegylated interferon

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1329082C (zh) * 1998-10-16 2007-08-01 拜奥根Idec马萨诸塞公司 干扰素－β－1a的聚合物缀合物及其使用
EA005005B1 (ru) 1998-10-16 2004-10-28 Байоджен, Инк. ГИБРИДНЫЙ ПОЛИПЕПТИД β1α-ИНТЕРФЕРОНА ЧЕЛОВЕКА, ЕГО МУТАНТНЫЕ ФОРМЫ И ПРОИЗВОДНЫЕ И СОДЕРЖАЩАЯ ИХ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ
US7144574B2 (en) 1999-08-27 2006-12-05 Maxygen Aps Interferon β variants and conjugates
US7431921B2 (en) 2000-04-14 2008-10-07 Maxygen Aps Interferon beta-like molecules
AU2002212107A1 (en) * 2000-11-02 2002-05-15 Maxygen Aps New multimeric interferon beta polypeptides
CZ20032526A3 (cs) 2001-02-27 2003-12-17 Maxygen Aps Nové molekuly podobné interferonu beta
WO2002072019A2 (fr) * 2001-03-13 2002-09-19 Vical Incorporated Therapie par polynucleotide codant un interferon-beta pour des maladies auto-immunes et inflammatoires
KR100511749B1 (ko) * 2001-11-06 2005-09-02 선바이오(주) 변형된 인터페론-베타, 및 이의 화학적으로 변형된 배합체
ME00239B (me) 2002-01-18 2011-05-10 Biogen Ma Inc Polimerna jedinjenja polialkilena i njihova upotreba
AU2003254641A1 (en) * 2002-08-28 2004-03-19 Maxygen Aps Interferon beta-like molecules for treatment of cancer
PT1667708E (pt) * 2002-12-26 2012-09-14 Mountain View Pharmaceuticals Conjugados de interferão-beta-1b e polietileno glicol apresentando uma potência biológica in vitro aumentada
US7691975B2 (en) 2003-08-25 2010-04-06 Toray Industries, Inc. Interferon-β complex
US20090311216A1 (en) * 2006-08-08 2009-12-17 Deborah Johnson-Jackson Recombinant interferon-beta with enhanced biological activity
US7625555B2 (en) 2007-06-18 2009-12-01 Novagen Holding Corporation Recombinant human interferon-like proteins
CN104043112B (zh) * 2014-07-01 2016-03-30 哈药集团生物工程有限公司 一种含有重组人干扰素α-2b(假单胞菌)的软膏药物组合物
EP3454887B1 (fr) * 2016-05-13 2021-01-20 Orionis Biosciences BV Interféron bêta mutant ciblé, et utilisations associées

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62503171A (ja) * 1985-06-26 1987-12-17 シタス　コ−ポレイシヨン ポリマ−接合を利用する医薬組成物用蛋白質の可溶化
JPH02502646A (ja) * 1987-12-23 1990-08-23 ジェネティックス・インスティテュート・インコーポレイテッド 親水性基に対する共有結合を容易ならしめるためのポリペプチド類の部位特異的均一修飾
WO1998035026A1 (fr) * 1997-02-06 1998-08-13 Novo Nordisk A/S Conjugats polypeptide-polymere a groupes de fixation ajoutes et/ou retires
WO1999003887A1 (fr) * 1997-07-14 1999-01-28 Bolder Biotechnology, Inc. Derives d'hormone de croissance et proteines associees

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4917888A (en) * 1985-06-26 1990-04-17 Cetus Corporation Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation
US5206344A (en) * 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
US5218092A (en) * 1988-09-29 1993-06-08 Kyowa Hakko Kogyo Co., Ltd. Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
IL113280A (en) * 1994-04-12 2004-12-15 Res Dev Foundation A preparation for the treatment of self-immunization diseases with the help of interferon of one type
US5738846A (en) * 1994-11-10 1998-04-14 Enzon, Inc. Interferon polymer conjugates and process for preparing the same
CN1329082C (zh) * 1998-10-16 2007-08-01 拜奥根Idec马萨诸塞公司 干扰素－β－1a的聚合物缀合物及其使用

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62503171A (ja) * 1985-06-26 1987-12-17 シタス　コ−ポレイシヨン ポリマ−接合を利用する医薬組成物用蛋白質の可溶化
JPH02502646A (ja) * 1987-12-23 1990-08-23 ジェネティックス・インスティテュート・インコーポレイテッド 親水性基に対する共有結合を容易ならしめるためのポリペプチド類の部位特異的均一修飾
WO1998035026A1 (fr) * 1997-02-06 1998-08-13 Novo Nordisk A/S Conjugats polypeptide-polymere a groupes de fixation ajoutes et/ou retires
WO1999003887A1 (fr) * 1997-07-14 1999-01-28 Bolder Biotechnology, Inc. Derives d'hormone de croissance et proteines associees

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008524296A (ja) * 2004-12-22 2008-07-10 エフ．ホフマン−ラ ロシュ アーゲー インスリン様増殖因子−１とポリ（エチレングリコール）のコンジュゲート
JP2010536788A (ja) * 2007-08-16 2010-12-02 ファーマエッセンティア コーポレイション タンパク質−高分子結合体
US11559567B2 (en) 2014-11-06 2023-01-24 Pharmaessentia Corporation Dosage regimen for pegylated interferon

Also Published As

Publication number Publication date
AU6687000A (en) 2001-03-26
NO20020929D0 (no) 2002-02-26
NO20020929L (no) 2002-04-25
HUP0302674A2 (hu) 2003-11-28
SK2942002A3 (en) 2002-08-06
BR0013638A (pt) 2002-05-14
MXPA02001969A (es) 2003-07-21
IL147581A0 (en) 2002-08-14
WO2001015736A3 (fr) 2003-05-22
EP1328295A2 (fr) 2003-07-23
CZ2002521A3 (cs) 2002-05-15
WO2001015736A2 (fr) 2001-03-08
CA2380760A1 (fr) 2001-03-08
CN1501815A (zh) 2004-06-02
KR20020034181A (ko) 2002-05-08

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