JP2003225298A - Adhesive plaster - Google Patents
Adhesive plasterInfo
- Publication number
- JP2003225298A JP2003225298A JP2002029031A JP2002029031A JP2003225298A JP 2003225298 A JP2003225298 A JP 2003225298A JP 2002029031 A JP2002029031 A JP 2002029031A JP 2002029031 A JP2002029031 A JP 2002029031A JP 2003225298 A JP2003225298 A JP 2003225298A
- Authority
- JP
- Japan
- Prior art keywords
- plaster
- adhesive
- eggshell membrane
- bandage
- hydrolyzed eggshell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000853 adhesive Substances 0.000 title claims abstract description 68
- 230000001070 adhesive effect Effects 0.000 title claims abstract description 67
- 239000011505 plaster Substances 0.000 title claims abstract description 66
- 239000000463 material Substances 0.000 claims abstract description 40
- 229940012466 egg shell membrane Drugs 0.000 claims description 65
- 239000010410 layer Substances 0.000 claims description 38
- 239000000499 gel Substances 0.000 claims description 31
- 239000007788 liquid Substances 0.000 claims description 13
- 239000000017 hydrogel Substances 0.000 claims description 12
- 238000001035 drying Methods 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 239000011247 coating layer Substances 0.000 claims description 7
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 5
- 239000003899 bactericide agent Substances 0.000 claims description 5
- 239000004909 Moisturizer Substances 0.000 claims description 4
- 239000000730 antalgic agent Substances 0.000 claims description 4
- 239000002826 coolant Substances 0.000 claims description 4
- 239000003205 fragrance Substances 0.000 claims description 4
- 230000001333 moisturizer Effects 0.000 claims description 4
- 239000011782 vitamin Substances 0.000 claims description 4
- 229940088594 vitamin Drugs 0.000 claims description 4
- 229930003231 vitamin Natural products 0.000 claims description 4
- 235000013343 vitamin Nutrition 0.000 claims description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 239000003755 preservative agent Substances 0.000 claims description 2
- 229940035676 analgesics Drugs 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 230000008929 regeneration Effects 0.000 abstract description 17
- 238000011069 regeneration method Methods 0.000 abstract description 17
- 230000035876 healing Effects 0.000 abstract description 5
- 239000002313 adhesive film Substances 0.000 abstract description 4
- 230000003301 hydrolyzing effect Effects 0.000 abstract description 4
- 238000005470 impregnation Methods 0.000 abstract description 4
- 210000000998 shell membrane Anatomy 0.000 abstract 3
- 206010040882 skin lesion Diseases 0.000 abstract 2
- 231100000444 skin lesion Toxicity 0.000 abstract 2
- 239000002390 adhesive tape Substances 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 description 31
- 206010052428 Wound Diseases 0.000 description 30
- 210000003491 skin Anatomy 0.000 description 25
- 230000001737 promoting effect Effects 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 239000004745 nonwoven fabric Substances 0.000 description 7
- 239000000123 paper Substances 0.000 description 7
- 102000002322 Egg Proteins Human genes 0.000 description 6
- 108010000912 Egg Proteins Proteins 0.000 description 6
- 206010061218 Inflammation Diseases 0.000 description 6
- 230000004054 inflammatory process Effects 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 210000003278 egg shell Anatomy 0.000 description 5
- -1 acryl Chemical group 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 210000004207 dermis Anatomy 0.000 description 4
- 210000004379 membrane Anatomy 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 239000002985 plastic film Substances 0.000 description 4
- 230000037380 skin damage Effects 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 238000005520 cutting process Methods 0.000 description 3
- 235000013601 eggs Nutrition 0.000 description 3
- 210000005081 epithelial layer Anatomy 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 230000036560 skin regeneration Effects 0.000 description 3
- 241000271566 Aves Species 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 229920002457 flexible plastic Polymers 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000005022 packaging material Substances 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000009423 ventilation Methods 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- 239000002759 woven fabric Substances 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- IYLLULUTZPKQBW-UHFFFAOYSA-N Acrinol Chemical compound CC(O)C(O)=O.C1=C(N)C=CC2=C(N)C3=CC(OCC)=CC=C3N=C21 IYLLULUTZPKQBW-UHFFFAOYSA-N 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 101710129611 Em protein Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 102000015728 Mucins Human genes 0.000 description 1
- 108010063954 Mucins Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000012790 adhesive layer Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- 229960001950 benzethonium chloride Drugs 0.000 description 1
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- ALEXXDVDDISNDU-JZYPGELDSA-N cortisol 21-acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O ALEXXDVDDISNDU-JZYPGELDSA-N 0.000 description 1
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 102000034240 fibrous proteins Human genes 0.000 description 1
- 108091005899 fibrous proteins Proteins 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- 229960001067 hydrocortisone acetate Drugs 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229960004393 lidocaine hydrochloride Drugs 0.000 description 1
- YECIFGHRMFEPJK-UHFFFAOYSA-N lidocaine hydrochloride monohydrate Chemical compound O.[Cl-].CC[NH+](CC)CC(=O)NC1=C(C)C=CC=C1C YECIFGHRMFEPJK-UHFFFAOYSA-N 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 229920000620 organic polymer Polymers 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 229920000247 superabsorbent polymer Polymers 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は創傷被覆部に加水分
解卵殻膜を含有させた絆創膏に関する。本発明の絆創膏
は、創傷被覆部に含まれる加水分解卵殻膜が、損傷を受
けた皮膚の再生促進作用を有し、また炎症の緩和作用を
有するため、損傷を受けた皮膚の治癒が速やかに行われ
る。TECHNICAL FIELD The present invention relates to a plaster containing a hydrolyzed eggshell membrane in a wound covering part. The adhesive bandage of the present invention, the hydrolyzed eggshell membrane contained in the wound covering part has a regeneration promoting action on damaged skin, and also has an action to alleviate inflammation, so that the healing of damaged skin is promptly performed. Done.
【０００２】[0002]
【従来の技術】ヒトの皮膚は、表面にある上皮層と、そ
の下の結合組織性の真皮層からなっている。上皮層を構
成するタンパク質は主としてケラチンであり、ケラチン
は皮膚の保護作用を有し、また上皮層に含まれるメラニ
ン（色素）は紫外線に対する防護作用を有する。一方、
真皮層を構成するタンパク質は主としてコラーゲンであ
り、他にエラスチン、アルブミン、グロブリン、ムチン
よりなっている。ケガなどによって皮膚に損傷が生じ、
その損傷が真皮層にまで達する場合には、真皮層を構成
しているコラーゲンも切断、破壊される。BACKGROUND OF THE INVENTION Human skin consists of a superficial epithelial layer and an underlying connective tissue dermis layer. The protein constituting the epithelial layer is mainly keratin, which has a protective effect on the skin, and the melanin (pigment) contained in the epithelial layer has a protective effect against ultraviolet rays. on the other hand,
The protein that constitutes the dermis layer is mainly collagen, and other components are elastin, albumin, globulin, and mucin. Damage to the skin due to injury,
When the damage reaches the dermis layer, the collagen constituting the dermis layer is also cut and destroyed.
【０００３】粘着性の支持体上に不織布製のバッド材を
取り付けた救急絆創膏が従来から広く用いられている。
しかしながら、従来の絆創膏は、主として損傷部の保護
のために用いられており、絆創膏自体が皮膚損傷部の再
生を促進する作用は低い。かかる点から、皮膚損傷部を
保護すると共にその再生を促進して、傷を早期に治癒す
ることのできる絆創膏が求められている。また、皮膚の
損傷面積が大きい場合や損傷の程度が大きい場合には、
支持体上に薬効成分を含有させた含水ゲル膏体層を設け
た絆創膏（いわゆるパップ剤タイプの絆創膏）が用いら
れているが、そのようなパップ剤タイプの絆創膏におい
ても、損傷した皮膚の再生を促進して傷を早期に治癒す
ることのできるものが求められている。[0003] First aid bandages in which a non-woven pad material is attached to an adhesive support have been widely used.
However, the conventional adhesive bandage is mainly used for protecting the damaged part, and the adhesive bandage itself has a low action of promoting the regeneration of the damaged part of the skin. From this point of view, there is a demand for a bandage that protects a skin-damaged part and promotes its regeneration to heal a wound early. If the area of skin damage is large or the degree of damage is large,
An adhesive bandage (so-called poultice type adhesive bandage) in which a hydrous gel plaster layer containing a medicinal component is provided on a support is used, but even in such an adhesive type patch adhesive bandage, regeneration of damaged skin is possible. There is a need for something that can promote wound healing and heal wounds early.
【０００４】卵殻膜は、鶏卵などの鳥類の卵の卵殻の内
側にある膜で、内外２枚からなり、外卵殻膜は卵殻内面
に密着し、内卵殻膜は卵白を包んでいる。卵殻膜は、強
靭な繊維性のタンパク質よりなり、オポケラチンとオポ
ムシンを主成分とする。卵殻膜は皮膚の再生を促進する
働きを有することが報告されているが、卵殻膜は水に不
溶であり、そのため、救急絆創膏のバッド材に含浸させ
ることが困難であり、またパップ剤タイプの絆創膏にお
いても含水ゲル膏体層中に均一に含有させることが困難
である。The eggshell membrane is a membrane located inside the eggshell of the eggs of birds such as chicken eggs, and consists of two inner and outer shells. The outer eggshell membrane adheres to the inner surface of the eggshell, and the inner eggshell membrane wraps the egg white. The eggshell membrane is composed of a tough fibrous protein, and is mainly composed of opokeratin and opomesin. It is reported that the eggshell membrane has a function of promoting the regeneration of the skin, but the eggshell membrane is insoluble in water, so that it is difficult to impregnate the pad material of the first-aid bandage, and also the type of poultice type. Even in a bandage, it is difficult to make it uniformly contained in the hydrous gel plaster layer.
【０００５】[0005]
【発明が解決しようとする課題】本発明の目的は、皮膚
の損傷部を単に保護するだけではなく、損傷した皮膚の
再生を促進して、傷を早期に治癒することのできる絆創
膏を提供することである。DISCLOSURE OF THE INVENTION An object of the present invention is to provide a bandage that not only protects a damaged part of the skin but also promotes regeneration of the damaged skin and can heal the wound early. That is.
【０００６】[0006]
【課題を解決するための手段】上記の目的を達成すべ
く、本発明者は鋭意検討を重ねてきた。その結果、卵殻
膜の加水分解物（加水分解卵殻膜）が、加水分解後も優
れた皮膚の再生促進作用を有し、また炎症の緩和作用を
有することを見出した。さらに、本発明者は、加水分解
卵殻膜は水溶性であるために、創傷被覆層をなす救急絆
創膏のバッド材に水溶液などの形態で容易に含浸付着さ
せることができ、またパップ剤タイプの絆創膏の含水ゲ
ル膏体中にも均一に混合することができ、それによって
損傷部の保護作用だけでなく損傷した皮膚の再生促進作
用を有する絆創膏が得られることを見出し、それらの知
見に基づいて本発明を完成した。[Means for Solving the Problems] In order to achieve the above object, the present inventor has conducted extensive studies. As a result, they have found that a hydrolyzate of eggshell membranes (hydrolyzed eggshell membranes) has an excellent skin regeneration promoting action even after hydrolysis and an inflammation relieving action. Furthermore, since the hydrolyzed eggshell membrane is water-soluble, the present inventor can easily impregnate and attach it to a pad material of an emergency adhesive bandage forming a wound covering layer in the form of an aqueous solution or the like, and a patch type adhesive bandage. It was found that it can be evenly mixed in the hydrous gel plaster of, thereby providing a bandage that has not only a protective effect on the damaged part but also a regeneration promoting effect on damaged skin, and based on these findings, Completed the invention.
【０００７】すなわち、本発明は、（１） 支持体上
に、加水分解卵殻膜を含有する創傷被覆層を設けたこと
を特徴とする絆創膏である。That is, the present invention is (1) a bandage characterized in that a wound covering layer containing a hydrolyzed eggshell membrane is provided on a support.
【０００８】そして、本発明は、（２） 創傷被覆層
が、加水分解卵殻膜を含有する含水ゲル膏体からなる層
である前記(１）の絆創膏；（３） 含水ゲル膏体が、
アクリル系含水ゲル膏体である前記（２）の絆創膏；お
よび、（４） 含水ゲル膏体の質量に対して加水分解卵
殻膜を０．５質量％以上の割合で含有する前記（２）ま
たは（３）の絆創膏；である。According to the present invention, (2) the wound dressing layer is a layer composed of a hydrous gel plaster containing a hydrolyzed eggshell membrane; (3) the hydrous gel plaster;
(2) The adhesive plaster of (2) which is an acryl-based hydrogel plaster; and (4) (2) or which contains a hydrolyzed eggshell membrane in a proportion of 0.5% by mass or more based on the mass of the hydrogel gel. It is a bandage of (3).
【０００９】さらに、本発明は、（５） 創傷被覆層
が、加水分解卵殻膜を含有する液を含浸した後に乾燥し
てなるバッド材からなる層である前記（１）の絆創膏；
および、（６） バッド材に含浸する加水分解卵殻膜を
含有する液中での加水分解卵殻膜の濃度が２〜２０質量
％である前記（５）の絆創膏；である。The present invention further provides (5) the bandage according to the above (1), wherein the wound coating layer is a layer made of a bad material which is obtained by impregnating a liquid containing a hydrolyzed eggshell membrane and then drying the wound coating layer;
And (6) the adhesive plaster according to (5) above, wherein the concentration of the hydrolyzed eggshell membrane in the liquid containing the hydrolyzed eggshell membrane impregnated in the pad material is 2 to 20% by mass.
【００１０】そして、本発明は、（７） 創傷被覆層
が、造膜剤、殺菌剤、消炎・鎮痛剤、香料、清涼化剤、
保湿剤、防腐剤およびビタミンのうちの１種または２種
以上を更に含有する前記（１）〜（６）のいずれかの絆
創膏である。The present invention also provides (7) a wound coating layer comprising a film-forming agent, a bactericidal agent, an anti-inflammatory / analgesic agent, a fragrance, a cooling agent,
The adhesive plaster according to any of (1) to (6) above, further containing one or more of a moisturizer, an antiseptic, and a vitamin.
【００１１】[0011]
【発明の実施の形態】以下に本発明について詳細に説明
する。本発明では用いる加水分解卵殻膜は、鳥類の卵の
卵殻の内側にある膜（外卵殻膜および／または内卵殻
膜）を蛋白質分解酵素、酸、アルカリなどを用いて加水
分解したものである。本発明では、加水分解卵殻膜とし
て、水に可溶であるか、または水に易分散性の加水分解
卵殻膜が好ましく用いられ、具体例としては、キューピ
ー株式会社製の「ＥＭプロテイン」（商品名）などを挙
げることができる。BEST MODE FOR CARRYING OUT THE INVENTION The present invention will be described in detail below. The hydrolyzed eggshell membrane used in the present invention is obtained by hydrolyzing a membrane (outer eggshell membrane and / or inner eggshell membrane) inside the eggshell of an avian egg with a proteolytic enzyme, acid, alkali or the like. In the present invention, a water-soluble or water-dispersible hydrolyzed egg shell membrane is preferably used as the hydrolyzed egg shell membrane, and specific examples thereof include "EM Protein" manufactured by Kewpie Co., Ltd. Name) etc. can be mentioned.
【００１２】本発明には、支持体上に加水分解卵殻膜を
含有する創傷被覆層を設けてなる絆創膏のいずれもが包
含される。そのうちでも、本発明の絆創膏の代表として
は、（Ａ） 支持体上に、加水分解卵殻膜を含有する含
水ゲル膏体からなる層を創傷被覆層として設けた絆創膏
（いわゆるパップ剤タイプの絆創膏）（以下これを「絆
創膏Ａ」ということがある）；および、（Ｂ） 加水分
解卵殻膜を含有する液を含浸した後に乾燥してなるバッ
ド材を、支持体上に創傷被覆層として設けた絆創膏（い
わゆる救急絆創膏タイプのもの）（以下これを「絆創膏
Ｂ」ということがある）；を挙げることができる。The present invention includes any of the plasters in which a wound coating layer containing a hydrolyzed eggshell membrane is provided on a support. Among them, as a representative of the adhesive bandage of the present invention, (A) an adhesive bandage (a so-called poultice type adhesive bandage) in which a layer made of a hydrous gel shell containing a hydrolyzed eggshell membrane is provided as a wound covering layer on a support (Hereinafter, this may be referred to as "Band plaster A"); and (B) A bandage in which a pad material, which is obtained by impregnating a liquid containing a hydrolyzed eggshell membrane and then drying, is provided as a wound covering layer on the support. (A so-called first-aid bandage type) (hereinafter, this may be referred to as "a bandage B");
【００１３】そこで、まず、絆創膏Ａについて説明す
る。絆創膏Ａは、加水分解卵殻膜を含有する含水ゲル膏
体を、支持体上に層状に施して創傷被覆層を形成し、必
要に応じてその表面を離型性のフィルムやシート（例え
ばポリエチレンフィルムなど）で覆ったものである。絆
創膏Ａの使用時には、従来公知の各種パップ剤と同様
に、絆創膏Ａの表面を覆っている離型性のフィルムまた
はシートを剥がし、加水分解卵殻膜を含有する含水ゲル
膏体層（創傷被覆層）を損傷部に当接・貼付して用いら
れる。Therefore, first, the adhesive plaster A will be described. The adhesive bandage A is a hydrogel shell containing a hydrolyzed eggshell membrane applied in layers on a support to form a wound coating layer, and the surface thereof may be releasable from a film or sheet (eg, polyethylene film) if necessary. Etc.). When the adhesive bandage A is used, the releasable film or sheet covering the surface of the adhesive bandage A is peeled off, and the hydrous gel shell layer containing the hydrolyzed eggshell membrane (wound covering layer) is used as in the case of various conventionally known poultices. ) Is used by abutting and affixing to the damaged part.
【００１４】絆創膏Ａにおいて、創傷被覆層を形成する
含水ゲル膏体としては、いわゆるパップ剤（パップ剤タ
イプの絆創膏）において従来から用いられている含水ゲ
ル膏体であればいずれも使用でき、例えば、ポリアクリ
ル酸、ポリアクリル酸ナトリウムなどの水溶性アクリル
系重合体を主体とするアクリル系含水ゲル膏体、カルボ
キシメチルセルロースナトリウムなどのセルロース誘導
体を主体とする含水ゲル膏体、アルギン酸ナトリウムを
主体とする含水ゲル膏体、ゼラチンを主体とする含水ゲ
ル膏体、ポリビニルアルコールに高吸水性高分子化合物
および／または親水性高分子化合物を配合した含水ゲル
膏体などを挙げることができる。そのうちでも、絆創膏
Ａでは、含水ゲル膏体として、アクリル系含水ゲル膏体
が好ましく用いられる。絆創膏Ａの創傷被覆層を構成す
る含水ゲル膏体の含水率は、含水ゲル膏体の種類、絆創
膏Ａの用途などに応じて適宜調節することができるが、
一般的には含水ゲル膏体の含水率は５０質量％以上であ
ることが好ましい。As the hydrous gel plaster forming the wound covering layer in the plaster A, any hydrous gel plaster conventionally used in so-called poultices (puppo type adhesive plasters) can be used. , Polyacrylic acid, acrylic hydrogel mainly composed of water-soluble acrylic polymer such as sodium polyacrylate, hydrogel gel mainly composed of cellulose derivative such as sodium carboxymethyl cellulose, and mainly sodium alginate Examples thereof include a hydrated gel plaster, a hydrated gel plaster mainly containing gelatin, and a hydrated gel plaster obtained by blending polyvinyl alcohol with a superabsorbent polymer compound and / or a hydrophilic polymer compound. Among them, in the adhesive plaster A, an acrylic hydrogel plaster is preferably used as the hydrogel plaster. The water content of the hydrous gel plaster constituting the wound coating layer of the adhesive bandage A can be appropriately adjusted according to the type of the hydrous gel plaster, the application of the adhesive bandage A, and the like.
Generally, the water content of the hydrogel plaster is preferably 50% by mass or more.
【００１５】また、絆創膏Ａにおける支持体としては、
いわゆるパップ剤（パップ剤タイプの絆創膏）において
従来から用いられている支持体であればいずれも使用で
き、例えば、不織布、織布、編布、紙、プラスチックフ
ィルム、前記した材料の２つ以上を組み合わせた積層体
シートなどを挙げることができる。As the support for the adhesive bandage A,
Any support can be used as long as it is a support conventionally used in so-called poultices (poultice type plasters), for example, non-woven fabric, woven fabric, knitted fabric, paper, plastic film, two or more of the above-mentioned materials. Examples thereof include a laminated sheet combined with each other.
【００１６】創傷被覆層を構成する含水ゲル膏体におけ
る加水分解卵殻膜の含有量は、絆創膏Ａの用途などに応
じて調整し得るが、一般的には、加水分解卵殻膜を添加
した後の含水ゲル膏体の全質量に基づいて、０．５質量
％以上であることが、皮膚の損傷部の再生促進効果など
の点から好ましく、２〜３０質量％、特に８〜１５質量
％であることが皮膚損傷部の再生促進効果、コスト、使
用感などの点からより好ましい。The content of the hydrolyzed eggshell membrane in the hydrous gel plaster constituting the wound covering layer can be adjusted according to the application of the adhesive bandage A, etc. Based on the total weight of the hydrous gel plaster, 0.5% by mass or more is preferable from the viewpoint of the effect of promoting regeneration of the damaged part of the skin, etc., and is 2 to 30% by mass, particularly 8 to 15% by mass. It is more preferable from the viewpoints of the effect of promoting regeneration of a damaged skin portion, cost, feeling of use and the like.
【００１７】絆創膏Ａの創傷被覆層を構成する含水ゲル
膏体層は、加水分解卵殻膜以外に、必要に応じて、造膜
剤、殺菌剤、消炎・鎮痛剤、他の薬効成分、香料、清涼
化剤、保湿剤、防腐剤、ビタミン、着色剤などの他の成
分の１種または２種以上を含有することができる。何ら
限定されるものではないが、造膜剤としては、例えばカ
ルボキシメチルキチン、他の有機重合体などを挙げるこ
とができ、殺菌剤としては、例えば、アクリノール、塩
化ベンゼトニウム、塩化ベンザルコニウムなどを挙げる
ことができる。また、消炎・鎮痛剤としては、例えば、
グリチルリチン酸ジカリウム、酢酸ヒドロコルチゾン、
塩酸リドカインなどを挙げることができる。また、保湿
剤としては、例えばブチレングリコール、プロピレング
リコール、ポリエチレングリコール、ポリプロピレング
リコール、プロパンジオール、グリセリン、マルチトー
ル、キシリトールなどの多価アルコールなどを挙げるこ
とができる。The water-containing gel plaster layer constituting the wound covering layer of the adhesive bandage A is, in addition to the hydrolyzed eggshell membrane, if necessary, a film-forming agent, a bactericidal agent, an anti-inflammatory / analgesic agent, other medicinal ingredients, a fragrance, It may contain one or more of other components such as a cooling agent, a moisturizing agent, an antiseptic, a vitamin and a coloring agent. Examples of the film-forming agent include, but are not limited to, carboxymethyl chitin and other organic polymers, and examples of the bactericidal agent include acrinol, benzethonium chloride, and benzalkonium chloride. Can be mentioned. In addition, as an anti-inflammatory / analgesic agent, for example,
Dipotassium glycyrrhizinate, hydrocortisone acetate,
Lidocaine hydrochloride and the like can be mentioned. Further, examples of the moisturizer include polyhydric alcohols such as butylene glycol, propylene glycol, polyethylene glycol, polypropylene glycol, propanediol, glycerin, maltitol, and xylitol.
【００１８】絆創膏Ａにおける含水ゲル膏体層の塗布量
は特に制限されないが、一般的には、支持体１００ｃｍ
2当たりの含水ゲル膏体の塗布量が、５〜２０ｇ程度、
特に８〜１５ｇ程度であることが、絆創膏Ａの製造の容
易性、絆創膏Ａの取り扱い性、皮膚損傷部に対する再生
促進効果、コスト、使用感などの点から好ましい。The amount of the water-containing gel plaster layer applied to the plaster A is not particularly limited, but in general, the support is 100 cm.
The amount of hydrogel plaster applied per 2 is about 5 to 20 g,
Particularly, about 8 to 15 g is preferable from the viewpoints of ease of production of the adhesive plaster A, handleability of the adhesive plaster A, effect of promoting regeneration on a skin-damaged part, cost, and feeling of use.
【００１９】絆創膏Ａの製造方法は特に制限されず、パ
ップ剤タイプの絆創膏において従来から採用されている
のと同様の方法で製造することができる。例えば、加水
分解卵殻膜、および必要に応じて他の成分を含有する含
水ゲル膏体を、スプレー塗装装置、ロールコーターなど
で支持体上に塗布することにより形成することができ
る。それによって製造された絆創膏Ａにおいて、含水ゲ
ル膏体層の含水率が所定の値になっている場合は、乾燥
処理を行わずに、そのまま含水ゲル膏体層の表面を必要
に応じて離型性フィルムなどで覆い、それを適当な包材
で包装すればよい。また、前記で製造された絆創膏Ａに
おける含水ゲル膏体層の含水率が所定の値よりも高い場
合は、所定の含水率になるまで乾燥した後に、含水ゲル
膏体層の表面を必要に応じて離型性フィルムなどで覆
い、それを適当な包材で包装すればよい。The method for producing the adhesive plaster A is not particularly limited, and the adhesive plaster A can be produced by the same method as has been conventionally used for a plaster type adhesive plaster. For example, it can be formed by applying a hydrolyzed eggshell membrane and a hydrous gel plaster containing other components as necessary on a support with a spray coating device, a roll coater or the like. When the water content of the hydrous gel plaster layer in the adhesive plaster A produced thereby is a predetermined value, the surface of the hydrous gel plaster layer is released as it is without performing a drying treatment. It may be covered with a flexible film or the like and then wrapped with an appropriate packaging material. Further, when the water content of the hydrous gel plaster layer in the adhesive bandage A produced above is higher than a predetermined value, the surface of the hydrous gel plaster layer is optionally dried after drying to a predetermined water content. It may be covered with a releasable film or the like and then wrapped with an appropriate packaging material.
【００２０】上記で得られる本発明の絆創膏Ａは、創傷
被覆層をなす含水ゲル膏体層中に皮膚の再生促進作用を
有する加水分解卵殻膜が含有されているので、損傷した
皮膚の再生を促進して傷を早期に治癒することができ
る。しかも、含水ゲル膏体層に含まれている加水分解卵
殻膜は、炎症の緩和作用をも有しているので、皮膚損傷
部の炎症を緩和して皮膚を再生を促すことができる。Since the adhesive bandage A of the present invention obtained above contains a hydrolyzed eggshell membrane having a skin regeneration promoting action in the hydrous gel plaster layer forming the wound covering layer, it can regenerate damaged skin. It can promote and heal wounds early. In addition, since the hydrolyzed eggshell membrane contained in the hydrous gel plaster layer also has an action of relieving inflammation, it is possible to relieve the inflammation of the damaged skin portion and promote the regeneration of the skin.
【００２１】次に本発明の絆創膏Ｂについて説明する。
絆創膏Ｂは、パッド材に加水分解卵殻膜を含有する液を
含浸した後に乾燥し、それを粘着性の支持体上に貼着し
たものであり、代表的には、傷テープなどと称されてい
る救急絆創膏を挙げることができる。Next, the plaster B of the present invention will be described.
Adhesive bandage B is obtained by impregnating a pad material with a liquid containing a hydrolyzed eggshell membrane and then drying it, and pasting it onto an adhesive support, which is typically called a wound tape or the like. The first-aid bandages are available.
【００２２】パッド材に含浸させる加水分解卵殻膜を含
有する液としては、乾燥後に安全なものであればいずれ
でもよく、例えば加水分解卵殻膜を含有する水溶液や水
分散液、加水分解卵殻膜を含有する水とアルコールの混
合溶媒の溶液や分散液などを挙げることができ、そのう
ちでも加水分解卵殻膜を含有する水溶液が好ましい。パ
ッド材に含浸させる加水分解卵殻膜を含有する液中での
加水分解卵殻膜の濃度は、適宜調整できるが、一般的に
は２〜２０質量％程度、特に８〜１５質量％程度である
ことが、皮膚の損傷部の再生促進効果、コスト、使用感
などの点から好ましい。また、加水分解卵殻膜を含有す
る液のパッド材への含浸量は、パッド材の種類、嵩密
度、厚さ、絆創膏Ｂの用途などに応じて調整し得るが、
一般的には、含浸前のパッド材の質量に対して、１００
〜５００質量％であることが、絆創膏Ｂの皮膚再生効
果、コスト、使用感などの点から好ましい。The liquid containing the hydrolyzed eggshell membrane with which the pad material is impregnated may be any liquid that is safe after drying. For example, an aqueous solution or aqueous dispersion containing the hydrolyzed eggshell membrane or a hydrolyzed eggshell membrane may be used. Examples thereof include a solution or dispersion of a mixed solvent of water and alcohol contained therein, and among them, an aqueous solution containing a hydrolyzed eggshell membrane is preferable. The concentration of the hydrolyzed eggshell membrane in the liquid containing the hydrolyzed eggshell membrane with which the pad material is impregnated can be appropriately adjusted, but is generally about 2 to 20% by mass, particularly about 8 to 15% by mass. However, it is preferable from the viewpoints of the effect of promoting regeneration of the damaged part of the skin, cost, feeling of use, and the like. Further, the impregnation amount of the liquid containing the hydrolyzed eggshell membrane into the pad material can be adjusted according to the type of pad material, the bulk density, the thickness, the use of the bandage B, etc.
Generally, it is 100 with respect to the mass of the pad material before impregnation.
It is preferable that the content is from about 500% by mass from the viewpoint of the skin regenerating effect of the adhesive bandage B, cost, and feeling of use.
【００２３】パッド材に含浸させる加水分解卵殻膜を含
有する液は、加水分解卵殻膜と共に、必要に応じて、造
膜剤、殺菌剤、消炎・鎮痛剤、他の薬効成分、香料、清
涼化剤、保湿剤、防腐剤、ビタミン、着色剤などの他の
成分の１種または２種以上を含有することができる。該
他の成分としては、例えば、絆創膏Ａの場合について上
記で挙げたのと同様のものを使用することができる。The liquid containing the hydrolyzed eggshell membrane with which the pad material is impregnated is, together with the hydrolyzed eggshell membrane, a film-forming agent, a bactericide, an antiphlogistic / analgesic, other medicinal ingredients, a fragrance, and a cooling agent, if necessary. One or more of other components such as agents, moisturizers, preservatives, vitamins, coloring agents and the like can be contained. As the other components, for example, those similar to those mentioned above in the case of the adhesive bandage A can be used.
【００２４】パッド材の種類や形態などは特に制限され
ず、救急絆創膏などにおいて従来から用いられているの
と同様のものを用いることができ、例えば、不織布、
紙、織布、編布などを挙げることができ、そのうちでも
不織布または紙が加水分解卵殻膜を含有する液の含浸
性、保持性に優れている点から好ましい。パッド材の厚
さは特に制限されず、従来の救急絆創膏などにおけるの
と同様の厚さにすればよく、一般的には０．２〜１．５
ｍｍ程度、特に０．２〜１．０ｍｍ程度の厚さが好まし
く採用される。The type and form of the pad material is not particularly limited, and the same material as that conventionally used in a first aid bandage can be used.
Examples thereof include paper, woven fabric, and knitted fabric, and among them, nonwoven fabric or paper is preferable because it is excellent in impregnation property and retention property of the liquid containing the hydrolyzed eggshell membrane. The thickness of the pad material is not particularly limited, and may be the same as that in a conventional first-aid bandage, etc., and generally 0.2 to 1.5.
A thickness of about mm, particularly about 0.2 to 1.0 mm is preferably adopted.
【００２５】次いで、加水分解卵殻膜を含有する液を含
浸させたパッド材を乾燥する。乾燥方法や条件は特に制
限されず、パッド材やそれに含浸されている成分の変性
や変質を生じない乾燥方法および条件であればいずれで
もよい。加水分解卵殻膜を含有する乾燥後のパッド材
は、適当な大きさに裁断して支持体をなす粘着シートや
粘着フィルムの粘着面に貼着する。加水分解卵殻膜を含
有するパッド材は支持体上にそのまま直接貼着してもよ
いが、皮膚損傷部へのパッド材の接着を防止するため
に、パッド材の表面（パッド材の少なくとも皮膚に接触
する表面部分）を、離型性のメッシュ体（メッシュ状フ
ィルムなど）で覆ってから、粘着シートや粘着フィルム
などからなる支持体上に貼着することが好ましい。絆創
膏Ｂのパッド材が皮膚損傷部に接着してしまうと、絆創
膏Ｂを剥がす際に、皮膚損傷部の表面部分がパッド材に
くっついた状態で剥がれてしまい、折角治癒しつつある
皮膚部分が再度ダメージを受けることになり好ましくな
い。パッド材の表面を覆う離型性のメッシュ体の種類な
どは特に制限されず、救急絆創膏などのパッド材の被覆
に従来から用いられて離型性メッシュ体と同様のものを
使用することができる。Next, the pad material impregnated with the liquid containing the hydrolyzed eggshell membrane is dried. The drying method and conditions are not particularly limited, and any drying method and conditions that do not cause modification or alteration of the pad material and the components impregnated therein may be used. The dried pad material containing the hydrolyzed eggshell membrane is cut into an appropriate size and attached to the adhesive surface of an adhesive sheet or an adhesive film forming a support. The pad material containing the hydrolyzed eggshell membrane may be directly stuck on the support, but in order to prevent the pad material from adhering to the skin damage part, the surface of the pad material (at least the skin of the pad material It is preferable that the contacting surface portion) is covered with a releasable mesh body (mesh-shaped film or the like) and then attached to a support made of an adhesive sheet or an adhesive film. If the pad material of the adhesive bandage B adheres to the skin damage part, when the adhesive bandage B is peeled off, the surface part of the skin damage part will be peeled off while sticking to the pad material, and the skin part that is healing at all It is not desirable because it will be damaged. The type of the releasable mesh body that covers the surface of the pad material is not particularly limited, and the same releasable mesh body that has been conventionally used for covering the pad material such as the first aid bandage can be used. .
【００２６】加水分解卵殻膜を含有するパッド材、好ま
しくは離型性メッシュで覆ったパッド材を貼着する支持
体の種類や形態などは特に制限されず、従来の救急絆創
膏などにおいて用いられているのと同様の、柔軟性のプ
ラスチックシートやフィルムをベースとする粘着シート
や粘着フィルムなどを用いることができる。従来の救急
絆創膏などにおけるのと同様に、支持体には通気のため
の小孔を多数設けておくことが好ましい。The type and form of the support to which the pad material containing the hydrolyzed eggshell membrane, preferably the pad material covered with the releasable mesh, is attached is not particularly limited, and it is used in conventional first-aid bandages and the like. It is possible to use an adhesive sheet or an adhesive film based on a flexible plastic sheet or film, which is similar to that described above. As in the case of conventional first-aid bandages, it is preferable that the support be provided with a large number of small holes for ventilation.
【００２７】上記で得られる絆創膏Ｂの表面を、従来の
救急絆創膏などと同様に、必要に応じて離型紙や離型性
フィルムで覆い、それを包装すればよい。本発明の絆創
膏Ｂは、皮膚損傷部に当接されるパッド材が皮膚の再生
を促進する加水分解卵殻膜を含有していることにより、
損傷した皮膚の再生を促進して傷を早期に治癒すること
ができる。しかも、パッド材に含まれている加水分解卵
殻膜は、炎症の緩和作用をも有しているので、皮膚損傷
部の炎症を緩和して皮膚の再生を促すことができる。If necessary, the surface of the adhesive bandage B obtained above may be covered with a release paper or a release film as in the case of a conventional first-aid bandage, and then wrapped. The adhesive bandage B of the present invention is characterized in that the pad material contacted with the skin-damaged part contains a hydrolyzed eggshell membrane that promotes skin regeneration.
It can promote the regeneration of damaged skin and heal wounds early. Moreover, since the hydrolyzed eggshell membrane contained in the pad material also has an action of relieving inflammation, it is possible to relieve the inflammation of the skin-damaged part and promote the regeneration of the skin.
【００２８】[0028]
【実施例】以下に実施例により本発明について具体的に
説明するが、本発明は以下の実施例により何ら限定され
ない。EXAMPLES The present invention will be specifically described below with reference to examples, but the present invention is not limited to the following examples.
【００２９】《実施例１》
（１） 下記の表１に示す成分を混合した後、室温下で
十分に（１５分間）撹拌して、含水ゲル膏体を調製し
た。Example 1 (1) After mixing the components shown in Table 1 below, the mixture was sufficiently stirred at room temperature (15 minutes) to prepare a hydrogel plaster.
【００３０】[0030]
【表１】 [Table 1]
【００３１】（２） 上記（１）で得られた加水分解卵
殻膜を含有する含水ゲル膏体を、ロールコーターを用い
て不織布（幅５０ｃｍ、目付２００ｇ／ｍ2）上に１０
ｇ／１００ｃｍ2の塗布量で塗布した後、含水ゲル膏体
層表面をポリエチレン製離型フィルムで覆い、縦×横＝
１５ｃｍ×１０ｃｍの寸法に裁断して、本発明の絆創膏
Ａを製造した。(2) The hydrous gel plaster containing the hydrolyzed eggshell membrane obtained in (1) above was applied onto a nonwoven fabric (width 50 cm, basis weight 200 g / m 2 ) 10 using a roll coater.
After coating with a coating amount of g / 100 cm 2, the surface of the water-containing gel plaster layer is covered with a polyethylene release film, and length × width =
The adhesive bandage A of the present invention was manufactured by cutting into a size of 15 cm × 10 cm.
【００３２】《実施例２》
（１） 下記の表２に示す成分を混合して加水分解卵殻
膜を含有する水溶液を調製した。Example 2 (1) The components shown in Table 2 below were mixed to prepare an aqueous solution containing a hydrolyzed eggshell membrane.
【００３３】[0033]
【表２】 [Table 2]
【００３４】（２） 上記（１）で得られた加水分解卵
殻膜を含有する水溶液を、セルロース製不織布（紙）
（厚さ０．３ｍｍ、幅５０ｃｍ、目付１２０ｇ／ｍ2）
に、不織布１００ｃｍ2当たり２．５ｇの割合で塗布し
て含浸させた後、１０５℃で乾燥した。
（３） 上記（２）で得られた加水分解卵殻膜を含有す
る乾燥不織布を１ｃｍ幅に切断した後、切断後の不織布
を離型性メッシュシートで被覆し（包み）、次いでそれ
を長さ２ｃｍに切断して、加水分解卵殻膜を含有するパ
ッド材（幅×長さ＝１ｃｍ×２ｃｍ）を製造した。
（４） 上記（３）で得られたパッド材を、通気用の小
孔を多数設けた支持体（一方の表面に粘着剤層を有する
柔軟性プラスチックフィルム）（幅×長さ＝１．５ｃｍ
×７ｃｍ）の粘着剤層側の中央部に貼着して取り付けた
後、その粘着面側を従来の救急絆創膏と同様に離型紙で
覆って、絆創膏Ｂを製造した。(2) The aqueous solution containing the hydrolyzed eggshell membrane obtained in (1) above is treated with a cellulose nonwoven fabric (paper).
(Thickness 0.3 mm, width 50 cm, basis weight 120 g / m 2 )
Was applied and impregnated at a rate of 2.5 g per 100 cm 2 of the nonwoven fabric, and then dried at 105 ° C. (3) After cutting the dried nonwoven fabric containing the hydrolyzed eggshell membrane obtained in (2) above to a width of 1 cm, the cut nonwoven fabric is covered (wrapped) with a releasable mesh sheet, and then the length thereof is adjusted. The pad material (width x length = 1 cm x 2 cm) containing a hydrolyzed eggshell membrane was produced by cutting into 2 cm. (4) The pad material obtained in (3) above is used as a support (flexible plastic film having a pressure-sensitive adhesive layer on one surface) provided with a large number of small holes for ventilation (width × length = 1.5 cm).
(7 cm) was attached and attached to the central portion of the adhesive layer side, and then the adhesive surface side was covered with release paper in the same manner as a conventional first-aid bandage to produce adhesive bandage B.
【００３５】《比較例１》加水分解卵殻膜を用いなかっ
た以外は実施例２と同様の成分を用いて、実施例２と同
様の操作を行って、パッド材部分に加水分解卵殻膜が含
有されていない絆創膏を製造した。Comparative Example 1 Using the same components as in Example 2 except that the hydrolyzed egg shell membrane was not used, the same procedure as in Example 2 was carried out, and the pad material portion contained the hydrolyzed egg shell membrane. Made a non-adhesive plaster.
【００３６】《試験例１》成人男子１０名を治験者と
し、それぞれの治験者の下腕部の内側に２カ所ずつ、紙
ヤスリを用いて血が滲む程度に軽く擦って傷を形成し、
一方の傷には実施例２で製造した絆創膏Ｂを貼り、もう
一方の傷には比較例１で製造した絆創膏を貼ってそのま
ま５日間放置した。５日後に、両方の絆創膏を剥がし
て、傷の治癒状態を目視により観察して、下記の表３に
示す評価基準に従って該当する人数を調べたところ、下
記の表４に示すとおりであった。<Test Example 1> Ten adult males were used as test subjects, and two scratches were formed on the inside of the lower arm of each test subject using a paper file to lightly rub to the extent that blood was blotted to form a wound,
The adhesive bandage B produced in Example 2 was applied to one of the wounds, and the adhesive bandage produced in Comparative Example 1 was applied to the other wound and left as it was for 5 days. After 5 days, both bandages were peeled off, the healing state of the wound was visually observed, and the corresponding number of people was examined according to the evaluation criteria shown in Table 3 below. The results are shown in Table 4 below.
【００３７】[0037]
【表３】 [Table 3]
【００３８】[0038]
【表４】 [Table 4]
【００３９】上記の表４の結果にみるように、創傷被覆
層（パッド材）に加水分解卵殻膜を含有する本発明の実
施例２の絆創膏は膚損傷部を再生を促進する作用を有し
ており、パッド材部分に加水分解卵殻膜を含有しない比
較例１の絆創膏に比べて、傷の治癒を速める効果があ
る。As can be seen from the results shown in Table 4 above, the adhesive plaster of Example 2 of the present invention containing a hydrolyzed eggshell membrane in the wound covering layer (pad material) has the action of promoting regeneration of the damaged skin area. In comparison with the adhesive plaster of Comparative Example 1 in which the pad material portion does not contain a hydrolyzed eggshell membrane, it has an effect of accelerating wound healing.
【００４０】[0040]
【発明の効果】本発明の絆創膏は、創傷被覆層に含まれ
る加水分解卵殻膜が、損傷を受けた皮膚の再生を促進す
る作用を有し、しかも炎症の緩和作用を有するため、損
傷を受けた皮膚の治癒を促進することができる。本発明
の絆創膏で用いている加水分解卵殻膜は、食用可能な卵
殻膜に由来するものであるため、本発明の絆創膏は安全
性の点でも優れている。INDUSTRIAL APPLICABILITY Since the hydrolyzed eggshell membrane contained in the wound covering layer has the action of promoting the regeneration of damaged skin and the action of alleviating inflammation, the bandage of the present invention is not damaged. Can promote healing of the skin. Since the hydrolyzed eggshell membrane used in the adhesive bandage of the present invention is derived from the edible eggshell membrane, the adhesive bandage of the present invention is also excellent in safety.
Claims (7)
創傷被覆層を設けたことを特徴とする絆創膏。1. A bandage comprising a support and a wound covering layer containing a hydrolyzed eggshell membrane.
る含水ゲル膏体からなる層である請求項１に記載の絆創
膏。2. The plaster according to claim 1, wherein the wound covering layer is a layer made of a hydrogel plaster containing a hydrolyzed eggshell membrane.
体である請求項２に記載の絆創膏。3. The adhesive plaster according to claim 2, wherein the hydrous gel plaster is an acrylic hydrogel plaster.
殻膜を０．５質量％以上の割合で含有する請求項２また
は３に記載の絆創膏。4. The adhesive plaster according to claim 2, which contains the hydrolyzed egg shell membrane in a proportion of 0.5% by mass or more based on the mass of the hydrous gel plaster.
る液を含浸した後に乾燥してなるバッド材からなる層で
ある請求項１に記載の絆創膏。5. The plaster according to claim 1, wherein the wound covering layer is a layer made of a bad material obtained by impregnating a liquid containing a hydrolyzed eggshell membrane and then drying.
有する液中での加水分解卵殻膜の濃度が２〜２０質量％
である請求項５に記載の絆創膏。6. The concentration of the hydrolyzed eggshell membrane in the liquid containing the hydrolyzed eggshell membrane impregnated in the pad material is 2 to 20% by mass.
The adhesive bandage according to claim 5.
鎮痛剤、香料、清涼化剤、保湿剤、防腐剤およびビタミ
ンのうちの１種または２種以上を更に含有する請求項１
〜６のいずれか１項に記載の絆創膏。7. A wound coating layer comprising a film-forming agent, a bactericidal agent, and an anti-inflammatory agent.
The method according to claim 1, further comprising one or more of analgesics, fragrances, cooling agents, moisturizers, preservatives and vitamins.
The adhesive plaster according to any one of 1 to 6.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002029031A JP4187976B2 (en) | 2002-02-06 | 2002-02-06 | Adhesive bandage |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002029031A JP4187976B2 (en) | 2002-02-06 | 2002-02-06 | Adhesive bandage |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003225298A true JP2003225298A (en) | 2003-08-12 |
| JP4187976B2 JP4187976B2 (en) | 2008-11-26 |
Family
ID=27749992
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002029031A Expired - Lifetime JP4187976B2 (en) | 2002-02-06 | 2002-02-06 | Adhesive bandage |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008073287A (en) * | 2006-09-22 | 2008-04-03 | Teikoku Seiyaku Co Ltd | Hydrogel wound covering material |
| WO2012029529A1 (en) | 2010-08-31 | 2012-03-08 | 天野エンザイム株式会社 | Eggshell membrane solubilization method using enzymes |
| US8563799B2 (en) | 2008-02-25 | 2013-10-22 | Teikoku Seiyaku Co., Ltd. | Wound-covering hydrogel material |
| US20140348939A1 (en) * | 2013-05-24 | 2014-11-27 | Robert C. Blaine | Wound care product with egg shell membrane |
| WO2016055676A1 (en) * | 2014-10-07 | 2016-04-14 | B.D.N. Ingeniería De Alimentación, S.L. | Method for obtaining a cicatrizant product and cicatrizant product obtained |
| US10932952B2 (en) | 2015-11-11 | 2021-03-02 | Biovotec As | Dry biocompatible disintegratable films for delivering particulate egg shell membrane to a wound |
| US11045578B2 (en) | 2015-06-24 | 2021-06-29 | Biovotec As | Tissue engineering scaffolds comprising particulate egg shell membrane |
| US11992508B2 (en) | 2014-10-28 | 2024-05-28 | Biovotec As | Micronized eggshell membrane particles and the use thereof to promote the healing of wounds |
-
2002
- 2002-02-06 JP JP2002029031A patent/JP4187976B2/en not_active Expired - Lifetime
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008073287A (en) * | 2006-09-22 | 2008-04-03 | Teikoku Seiyaku Co Ltd | Hydrogel wound covering material |
| US8563799B2 (en) | 2008-02-25 | 2013-10-22 | Teikoku Seiyaku Co., Ltd. | Wound-covering hydrogel material |
| WO2012029529A1 (en) | 2010-08-31 | 2012-03-08 | 天野エンザイム株式会社 | Eggshell membrane solubilization method using enzymes |
| US20140348939A1 (en) * | 2013-05-24 | 2014-11-27 | Robert C. Blaine | Wound care product with egg shell membrane |
| US10166260B2 (en) * | 2013-05-24 | 2019-01-01 | Blaine Laboratories, Inc. | Wound care product with egg shell membrane |
| WO2016055676A1 (en) * | 2014-10-07 | 2016-04-14 | B.D.N. Ingeniería De Alimentación, S.L. | Method for obtaining a cicatrizant product and cicatrizant product obtained |
| US11992508B2 (en) | 2014-10-28 | 2024-05-28 | Biovotec As | Micronized eggshell membrane particles and the use thereof to promote the healing of wounds |
| US11045578B2 (en) | 2015-06-24 | 2021-06-29 | Biovotec As | Tissue engineering scaffolds comprising particulate egg shell membrane |
| US10932952B2 (en) | 2015-11-11 | 2021-03-02 | Biovotec As | Dry biocompatible disintegratable films for delivering particulate egg shell membrane to a wound |
Also Published As
| Publication number | Publication date |
|---|---|
| JP4187976B2 (en) | 2008-11-26 |
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