JP2003135023A - Health food - Google Patents
Health foodInfo
- Publication number
- JP2003135023A JP2003135023A JP2001332458A JP2001332458A JP2003135023A JP 2003135023 A JP2003135023 A JP 2003135023A JP 2001332458 A JP2001332458 A JP 2001332458A JP 2001332458 A JP2001332458 A JP 2001332458A JP 2003135023 A JP2003135023 A JP 2003135023A
- Authority
- JP
- Japan
- Prior art keywords
- extract
- health food
- weight
- plants
- dried
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
Description
【０００１】[0001]
【発明の技術分野】本発明は、肝機能改善作用が高く、
且つ滋養、強壮食品として、倦怠感を改善する、有効な
食品に関する。TECHNICAL FIELD The present invention has a high liver function improving action,
Further, the present invention relates to an effective food as a nourishing and tonic food which improves fatigue.
【０００２】[0002]
【従来の技術】従来から、肝疾患をはじめとする種々の
疾患に対する薬等として有効な植物が利用されてきた。
そのような有効な植物として、マリアアザミ、ウコン、
田七人参、甘草、紅参、エビス草等が挙げられる。2. Description of the Related Art Conventionally, plants effective as drugs for various diseases including liver diseases have been used.
Such effective plants include thistle, turmeric,
Examples include field seven ginseng, licorice, red ginseng, and shrimp grass.
【０００３】マリアアザミは、オオアザミともいいキク
科の植物で、その種子は、ヨーロッパにおいて２０００
年以上も前から民間薬として、肝臓、胆嚢、脾臓、消化
管の疾患や、母乳不足等に対して広く利用されてきた。
マリアアザミにおける活性主体は、３種のフラボノリグ
ナンの混合物（シリマリン）である。Thistle, which is also called milk thistle, is a plant of the Asteraceae family whose seeds are 2,000 in Europe.
For more than a year, it has been widely used as a folk medicine for diseases of the liver, gallbladder, spleen, digestive tract, and lack of breast milk.
The active subject in thistle is a mixture of three flavonolignans (silymarin).
【０００４】また、ウコンは、ショウガ科の植物でター
メリッツクとも呼ばれ、その明るいスパイシーな風味は
カレー粉原料等にも使用されている。ウコンは、古来イ
ンドや中国等で消火器や肝臓の疾患に対する伝統的な治
療薬として用いられてきた。Turmeric is a plant of the ginger family and is also called turmeric, and its bright and spicy flavor is also used as a raw material for curry powder. Turmeric has been used as a traditional treatment for fire extinguisher and liver diseases in India and China since ancient times.
【０００５】また、田七人参は、ウコギ科の植物で三七
人参とも呼ばれ、ステロイドサポニンやフラボノイド等
を含み、古来より主に強壮薬として用いられてきた。田
七人参の強壮作用は、朝鮮人参と同様、副腎機能、特に
コルチコステロイドや男性ホルモンの産生によるもので
ある。また、この田七人参は、ほとんど全ての体内出血
に効果がある。[0007] In addition, Shichinin ginseng is a plant of the family Araliaceae, also called Shichinin ginseng, which contains steroid saponins and flavonoids, and has been mainly used as a tonic since ancient times. The tonic action of Ginseng, like ginseng, is due to adrenal function, especially the production of corticosteroids and male hormones. Also, this Ganoderma ginseng is effective for almost all internal bleeding.
【０００６】また、甘草は、ヨーロッパの薬の中では最
も汎用されている植物で、数千年前から薬用とされてお
り、生薬治療においては喘息、関節炎、口の潰瘍、神経
性胃潰瘍等の諸症状に最も効果があり、抗炎症薬として
の価値も高い。[0006] Licorice is the most widely used plant in European medicine, and has been used as a medicinal substance for thousands of years. In herbal medicine treatment, asthma, arthritis, mouth ulcer, nervous gastric ulcer, etc. It is most effective for various symptoms and has high value as an anti-inflammatory drug.
【０００７】また、紅参は、いわゆる朝鮮人参を蒸した
ものであり、その根が使用され、活性物質が最も濃縮さ
れる栽培４〜６年後に収穫される。紅参は、古来より強
壮薬として用いられており、過去２０〜３０年間、多く
の国々で詳細な研究が行なわれ、その顕著な性質が確認
された。紅参の主な活性成分は、ジンセノイドと呼ばれ
る成分である。また、紅参は、その成分としてサポニン
を多く含んでいる。[0007] Red ginseng is steamed so-called ginseng, and its roots are used and harvested 4 to 6 years after cultivation in which the active substance is most concentrated. Red ginseng has been used as a tonic since ancient times, and in the past 20 to 30 years, detailed studies have been conducted in many countries and its remarkable properties have been confirmed. The main active ingredient of red ginseng is an ingredient called ginsenoide. Red ginseng contains a large amount of saponin as its component.
【０００８】また、エビス草は、別名決明ともいい、こ
の種子を決明子という。中国では、このエビス草は、目
を明らかにするという意味で、視力を増す薬とされてい
る。決明子には、エモジン等のアランキトサンが多く含
まれており、緩やかに便通を良くする緩下剤としても用
いられている。[0008] The Ebisu grass is also called "Keimei", and this seed is called "Keimeiko". In China, this shrimp grass is said to be a medicine that enhances eyesight in the sense of revealing the eyes. Alan chitosan, such as emodin, is contained in a lot of determinants, and it is also used as a laxative that gently improves bowel movements.
【０００９】一方、肝機能改善については、改善薬等の
薬剤による治療は当然処方されているが、多くの人は肝
機能が多少悪くても適切な治療を怠り、難治化させてし
まう場合が多い。しかも、肝機能の悪化は症状としてな
かなか認知しにくく、明らかな症状として自覚した場合
には既にかなり進行している場合が多い。On the other hand, for improving liver function, treatment with drugs such as improving drugs is naturally prescribed, but in many cases, even if the liver function is somewhat poor, appropriate treatment may be neglected and the patient may be incurable. Many. Moreover, deterioration of liver function is difficult to recognize as a symptom, and in many cases, when it is recognized as a clear symptom, it has already progressed considerably.
【００１０】また、健康食品の類においても、複合的に
これらの植物類を多く組み合わせて、効果の高いものは
少なく、単品の植物の粉末あるいはエキスを製品化した
ものがほとんどである。また、肝機能の改善や、肝疾患
等の肝機能障害の予防効果が高い食品は少ないのが現状
であった。[0010] Also, in the category of health foods, many of these plants are combined in a complex manner and few are highly effective, and most of them are products of single plant powders or extracts. In addition, there are few foods that have a high effect of improving liver function and preventing liver dysfunction such as liver disease.
【００１１】[0011]
【発明が解決しようとする課題】従って、本発明は、倦
怠感を解消し、肝機能を改善すると共に、肝機能障害の
予防に有用な健康食品を提供することを課題とする。SUMMARY OF THE INVENTION Therefore, an object of the present invention is to eliminate fatigue and improve liver function, and to provide a health food useful for preventing liver dysfunction.
【００１２】[0012]
【課題を解決するための手段】本発明者等は、鋭意研究
した結果、既に人体への安全性が確認されている植物を
スクリーニングして調べ、肝機能改善効果として特に有
効に機能する６種の植物を特定し、かかる６種の特定植
物それぞれの抽出物又は乾燥物を含む組成物が、前記課
題を解決し得ることの知見を得た。Means for Solving the Problems As a result of intensive studies, the present inventors have screened and examined plants whose safety to human body has already been confirmed, and have 6 species which are particularly effective in improving liver function. It was found that a composition containing the extract or dried product of each of these 6 types of specific plants can solve the above problems.
【００１３】本発明は、前記知見に基づきなされたもの
で、マリアアザミ、ウコン、田七人参、甘草、紅参、及
びエビス草からなる６種の植物それぞれの抽出物又は乾
燥物を少なくとも含むことを特徴とする健康食品を提供
するものである。The present invention has been made based on the above findings, and contains at least an extract or a dried product of each of 6 kinds of plants consisting of thistle, thistle, turmeric, ginseng ginseng, licorice, red ginseng, and shrimps. The present invention provides a health food characterized by:
【００１４】[0014]
【発明の実施の形態】以下、本発明の健康食品を、その
好ましい実施形態に基づいて詳細に説明する。BEST MODE FOR CARRYING OUT THE INVENTION The health food of the present invention will be described in detail below based on its preferred embodiments.
【００１５】本発明の健康食品は、マリアアザミ、ウコ
ン、田七人参、甘草、紅参、及びエビス草からなる６種
の植物それぞれの抽出物又は乾燥物を少なくとも含むも
のである。本発明の健康食品は、このような構成からな
るため、前記各植物それぞれの抽出物又は乾燥物が相俟
って、倦怠感の解消効果、肝機能の改善効果、及び肝機
能障害の予防効果の全てを発現できるものである。The health food of the present invention contains at least an extract or a dried product of each of 6 kinds of plants consisting of thistle, thistle, turmeric, seven fields of ginseng, licorice, red ginseng and shrimp. Since the health food of the present invention has such a constitution, the extract or dried product of each of the above plants is combined, the effect of eliminating fatigue, the effect of improving liver function, and the effect of preventing liver dysfunction. Can express all of the above.
【００１６】本発明で言う「抽出物」には、抽出エキス
乾燥物、抽出エキス水、抽出エキス粉末等の抽出エキス
が含まれるが、特に効果を向上できる点で、抽出エキス
粉末が好ましい。本願明細書において、「抽出エキス」
とは、所定の植物の全部又は一部から抽出溶媒によって
有効成分を抽出したもの（溶媒抽出物）又はその濃縮物
をいい、液状物であると固形物であるとを問わない。The "extract" referred to in the present invention includes extract extracts such as dried extract, extract water, and extract powder, but the extract powder is preferable from the viewpoint that the effect can be particularly improved. In the present specification, "extract"
The term refers to a substance obtained by extracting the active ingredient from all or part of a predetermined plant with an extraction solvent (solvent extract) or a concentrate thereof, and may be a liquid substance or a solid substance.
【００１７】また、本発明で言う「乾燥物」には、所定
の植物の全部又は一部をそのまま乾燥して粉末状にした
乾燥粉末等が含まれる。Further, the "dry matter" referred to in the present invention includes a dry powder or the like obtained by drying all or part of a predetermined plant as it is into a powder form.
【００１８】抽出物又は乾燥物としては、抽出エキス又
は乾燥粉末、特に、６種の前記植物それぞれの全体、種
子、根又は茎の抽出エキス又は乾燥粉末であることが、
効果の向上の点で好ましい。The extract or dried product is an extract or a dry powder, in particular, an extract or a dry powder of the whole, seed, root or stem of each of the six plants mentioned above,
It is preferable in terms of improving the effect.
【００１９】更に、抽出物又は乾燥物は、マリアアザミ
の種子、ウコンの根及び茎、田七人参の根、甘草の根、
紅参の全体、及びエビス草の種子それぞれの抽出エキス
又は乾燥粉末であることが、効果の向上の点で好まし
い。Further, the extract or dried product is obtained from seeds of thistle, root and stem of turmeric, root of Radix Notoginseng, root of licorice,
Extracts or dry powders of the whole red ginseng and the seed of Ebisu grass are preferable from the viewpoint of improving the effect.
【００２０】本発明の健康食品が前記抽出物としての抽
出エキスを含む場合、該抽出エキスの抽出方法として
は、例えば、植物の全体又は所定の部位（種子、根、茎
等）を細切し、溶媒で抽出する方法等が挙げられる。抽
出溶媒としては、水（熱水、温水を含む）、エタノール
単体、又は水とエタノールとの混合物（エタノール濃度
５０重量％以下、特に１０〜３０重量％）等が好ましく
挙げられる。抽出溶媒の使用量は、植物の全体又は所定
の部位１重量部に対して、通常３〜２０重量部、特に５
〜１０重量部である。When the health food of the present invention contains the extract as the extract, the method for extracting the extract is, for example, the whole plant or a predetermined part (seed, root, stem, etc.) , Extraction with a solvent, and the like. Preferred examples of the extraction solvent include water (including hot water and warm water), ethanol alone, or a mixture of water and ethanol (ethanol concentration of 50% by weight or less, particularly 10 to 30% by weight). The amount of the extraction solvent used is usually 3 to 20 parts by weight, especially 5 parts by weight, based on 1 part by weight of the whole plant or a predetermined part.
10 to 10 parts by weight.
【００２１】また、抽出エキスは、室温で抽出したもの
でも、加熱抽出したものでもよい。植物から抽出溶媒に
より抽出した溶媒抽出物は、濃縮することが好ましく、
更には、スプレードライ方式（溶媒抽出物を高濃度に濃
縮した濃縮物を高温の釜の中で、霧状に噴霧し、高温の
空気を送り込むことで、残存する溶媒を瞬間的に揮発さ
せ、固形物として堆積させて、粉末等の固形の抽出エキ
スとする方式）により固形化し、粉末状等の抽出エキス
にすることが好ましい。尚、溶媒抽出物は、濃縮せずに
そのままの状態でも使用することもできる。The extracted extract may be one extracted at room temperature or one extracted by heating. The solvent extract extracted from the plant with the extraction solvent is preferably concentrated,
Furthermore, a spray dry method (a concentrated concentrate of the solvent extract is concentrated in a high-temperature kettle in a mist form, and hot air is blown in to instantaneously volatilize the remaining solvent, It is preferable that the extract is deposited as a solid and solidified by a solid extraction extract such as powder) to obtain a powdered extraction extract. The solvent extract can be used as it is without being concentrated.
【００２２】また、抽出エキスは、溶媒抽出物から濃縮
する場合には、その濃縮によって植物に対する最終的な
溶媒量が限りなく０になることが好ましい。このように
するには、例えば、濃縮過程において、溶媒抽出物から
水分及び抽出溶媒を熱により揮発させ、最終的にエキス
粉末にすることが好ましい。尚、抽出エキスを得る際に
使用する溶媒が残存する抽出物であっても、食品中にそ
の抽出エキスの量を多く含有させる等の調整により、エ
キス粉末を使用した場合と同等の効果を得ることが可能
である。When the extracted extract is concentrated from the solvent extract, it is preferable that the final amount of the solvent for the plant becomes zero as much as possible by the concentration. In order to do so, for example, in the concentration process, it is preferable to volatilize water and the extraction solvent from the solvent extract by heat to finally obtain an extract powder. Even if the extract used is the solvent used to obtain the extract, the same effect as when using the extract powder is obtained by adjusting the amount of the extract to be contained in the food. It is possible.
【００２３】本発明の健康食品が前記乾燥物を含む場
合、該乾燥物は、例えば、植物の全体又は所定の部位
（種子、根、茎等）を、６０℃以上、好ましくは６０〜
１００℃の温度で乾燥し、これを更に所定の大きさの粉
末にすべく、粉砕して微粉末化し、９０〜１００℃で滅
菌処理する等の公知の方法により乾燥粉末等にしたもの
が用いられる。When the health food of the present invention contains the dried product, the dried product may be, for example, the whole plant or a predetermined part (seed, root, stem, etc.) of 60 ° C. or higher, preferably 60 to 60 ° C.
It is dried at a temperature of 100 ° C., and is further pulverized into a fine powder in order to obtain a powder having a predetermined size, which is then dried into powder by a known method such as sterilization at 90 to 100 ° C. To be
【００２４】尚、これらの抽出物（特に抽出エキス）又
は乾燥物（特に乾燥粉末）は、市販品を利用することも
できる。As the extract (especially extract) or the dried product (especially dry powder), a commercially available product can be used.
【００２５】本発明の健康食品における６種の植物それ
ぞれの抽出物又は乾燥物の配合量について、特に該植物
それぞれの特定部位の抽出エキス又は乾燥粉末を配合す
る場合を一例として、各植物毎に以下に示す。Regarding the blending amount of the extract or dry product of each of the 6 kinds of plants in the health food of the present invention, particularly when the extract extract or dry powder of a specific part of each plant is blended, as an example, It is shown below.
【００２６】マリアアザミの種子の抽出エキスの配合量
は、本発明の健康食品中、好ましくは３〜３０重量％、
更に好ましくは５〜１５重量％である。また、マリアア
ザミの種子の乾燥粉末の配合量は、本発明の健康食品
中、好ましくは５〜５０重量％、更に好ましくは５〜２
０重量％である。The content of the extract of the extract of thistle of thistle is preferably 3 to 30% by weight in the health food of the present invention,
More preferably, it is 5 to 15% by weight. The dry powder of silybum marianum seeds is preferably contained in the health food of the present invention in an amount of 5 to 50% by weight, more preferably 5 to 2% by weight.
It is 0% by weight.
【００２７】ウコンの根及び茎の抽出エキスの配合量
は、本発明の健康食品中、好ましくは５〜３０重量％、
更に好ましくは１０〜２０重量％である。また、ウコン
の根及び茎の乾燥粉末の配合量は、本発明の健康食品
中、好ましくは１０〜５０重量％、更に好ましくは１０
〜２０重量％である。The amount of the extract of turmeric root and stem extracted in the health food of the present invention is preferably 5 to 30% by weight,
More preferably, it is 10 to 20% by weight. The amount of the dry powder of turmeric roots and stems contained in the health food of the present invention is preferably 10 to 50% by weight, more preferably 10% by weight.
Is about 20% by weight.
【００２８】田七人参の根の抽出エキスの配合量は、本
発明の健康食品中、好ましくは５〜３０重量％、更に好
ましくは１０〜２０重量％である。また、田七人参の根
の乾燥粉末の配合量は、本発明の健康食品中、好ましく
は１０〜５０重量％、更に好ましくは１０〜２０重量％
である。The amount of the extract of Radix Notoginseng root extracted in the health food of the present invention is preferably 5 to 30% by weight, more preferably 10 to 20% by weight. Moreover, the blending amount of the dry powder of the root of Ginseng root is preferably 10 to 50% by weight, more preferably 10 to 20% by weight in the health food of the present invention.
Is.
【００２９】甘草の根の抽出エキスの配合量は、本発明
の健康食品中、好ましくは３〜２０重量％、更に好まし
くは３〜１０重量％である。また、甘草の根の乾燥粉末
の配合量は、本発明の健康食品中、好ましくは５〜３０
重量％、更に好ましくは５〜１５重量％である。The content of the extract of licorice root extract in the health food of the present invention is preferably 3 to 20% by weight, more preferably 3 to 10% by weight. The amount of licorice root dry powder blended in the health food of the present invention is preferably 5 to 30.
%, More preferably 5 to 15% by weight.
【００３０】紅参の抽出エキスの配合量は、本発明の健
康食品中、好ましくは２〜２０重量％、更に好ましくは
３〜１０重量％である。また、紅参の乾燥粉末の配合量
は、本発明の健康食品中、好ましくは５〜３０重量％、
更に好ましくは５〜１５重量％である。The content of the red ginseng extract extract in the health food of the present invention is preferably 2 to 20% by weight, more preferably 3 to 10% by weight. The amount of dried red ginseng powder in the health food of the present invention is preferably 5 to 30% by weight,
More preferably, it is 5 to 15% by weight.
【００３１】エビス草の種子の抽出エキスの配合量は、
本発明の健康食品中、好ましくは３〜３０重量％、更に
好ましくは７〜１５重量％である。また、エビス草の種
子の乾燥粉末の配合量は、本発明の健康食品中、好まし
くは５〜３０重量％、更に好ましくは１０〜２０重量％
である。The amount of the extract of Ebisu grass seeds extracted is
In the health food of the present invention, it is preferably 3 to 30% by weight, more preferably 7 to 15% by weight. The dry powder of Ebisu grass seeds is contained in the health food of the present invention in an amount of preferably 5 to 30% by weight, more preferably 10 to 20% by weight.
Is.
【００３２】本発明で言う「健康食品」には、錠剤、ド
リンク剤、顆粒、粉末剤等が含まれる。The "health food" referred to in the present invention includes tablets, drinks, granules, powders and the like.
【００３３】本発明の健康食品を錠剤として使用する場
合には、６種の前記植物のそれぞれの抽出物又は乾燥物
に加えて、賦形剤が配合される。この賦形剤は、前記抽
出物又は乾燥物と共に配合され、固形化した錠剤として
の本発明の健康食品を形成するものである。When the health food of the present invention is used as a tablet, an excipient is added to the extract or dried product of each of the 6 kinds of plants. This excipient is combined with the extract or dried product to form the health food of the present invention as a solidified tablet.
【００３４】賦形剤としては、特に制限されるものでは
なく、例えば、セルロース、乳糖、パインファイバー、
デキストリン、パインデックス等が用いられる。これら
は、使用に際して、１種単独又は２種以上の混合物とし
て用いられる。The excipient is not particularly limited, and examples thereof include cellulose, lactose, pine fiber,
Dextrin, pa index, etc. are used. When used, they are used alone or as a mixture of two or more.
【００３５】賦形剤を用いる場合の配合量は、本発明の
健康食品中、好ましくは３０〜７０重量％、更に好まし
くは３０〜５０重量％である。When an excipient is used, its content in the health food of the present invention is preferably 30 to 70% by weight, more preferably 30 to 50% by weight.
【００３６】本発明の健康食品を錠剤とする際の形状
は、特に制限されず薬事法に準拠した範囲内で適宜設定
することができ、例えば、三角形状、球状、顆粒状等の
複数の粒等が挙げられる。また、この場合、一粒あたり
の重量は、使用態様等に応じて所望の重量に適宜決定で
きる。The shape of the health food of the present invention in the form of tablets is not particularly limited and may be appropriately set within the range in conformity with the Pharmaceutical Affairs Law. For example, a plurality of particles such as a triangular shape, a spherical shape and a granular shape may be used. Etc. Further, in this case, the weight per grain can be appropriately determined to a desired weight according to the usage mode and the like.
【００３７】本発明の健康食品には、前記の各種成分
（抽出物又は乾燥物、必要により賦形剤）以外に、食品
に使われる一般的な原料を添加することができ、常法に
より製造される。例えば、本発明の健康食品が錠剤の場
合、前記の各種成分（抽出物又は乾燥物）、及び必要に
応じ使用される添加剤を配合し、これに水若しくはエタ
ノール又は水とエタノールとの混合溶液を加えてこれら
を練りこみ、十分に混ぜ合わせる。これを５０〜１００
℃にて加えた水等の溶液を蒸発させ、十分に乾燥する。
その後、打錠する等によって、錠剤が製造される。To the health food of the present invention, in addition to the above-mentioned various components (extract or dried product, and if necessary, excipient), general raw materials used in foods can be added, and they can be produced by a conventional method. To be done. For example, when the health food of the present invention is a tablet, the above-mentioned various components (extract or dried product) and additives used as necessary are blended, and water or ethanol or a mixed solution of water and ethanol is added thereto. Knead these together and mix thoroughly. 50 to 100
Evaporate the added solution such as water at ℃ and dry thoroughly.
After that, tablets are produced by tableting or the like.
【００３８】本発明の健康食品は、本発明の効果を一層
発揮し得る観点から、１日１，０００〜１０，０００ｍ
ｇ、特に２，５００〜５，０００ｍｇを毎日継続して摂
取されることが好ましい。The health food of the present invention is 1,000 to 10,000 m per day from the viewpoint that the effects of the present invention can be further exerted.
It is preferable to continuously take g, particularly 2,500 to 5,000 mg daily.
【００３９】[0039]
【実施例】以下、実施例を示して本発明を更に具体的に
説明する。しかしながら、本発明はこれらの実施例によ
って何等限定されるものではない。EXAMPLES The present invention will be described in more detail below with reference to examples. However, the present invention is not limited to these examples.
【００４０】（実施例１）マリアアザミ、ウコン、田七
人参、甘草、紅参、及びエビス草それぞれの抽出エキス
を以下のようにして得た。(Example 1) Extracts of Silybum marianum, turmeric, Shichinin ginseng, licorice, red ginseng, and shrimp grass were obtained as follows.
【００４１】（マリアアザミの抽出エキス）乾燥マリア
アザミの種子１重量部に対し、抽出溶媒としての無水エ
タノール５重量部で室温抽出したものを加熱濃縮し、ス
プレードライにより粉末抽出エキスとした。これにより
加熱濃縮されて粉末となるエキスは、乾燥したマリアア
ザミの種子３５重量部に対し、粉末抽出エキス１重量部
得られるものである。(Extract of extract of Silybum marianum) One part by weight of dried seed of Silybum marianum was extracted at room temperature with 5 parts by weight of absolute ethanol as an extraction solvent, followed by heating and concentration to obtain a powder-extracted extract by spray drying. As a result, the extract which is heated and concentrated to form a powder is obtained by adding 1 part by weight of the powder extract to 35 parts by weight of dried thistle seeds.
【００４２】（ウコンの抽出エキス）乾燥したウコンの
根及び茎１重量部に対し、抽出溶媒としての水１０重量
部で加熱抽出したものを加熱濃縮し、スプレードライに
より粉末抽出エキスとした。これにより加熱濃縮されて
粉末となるエキスは、乾燥したウコンの根及び茎５重量
部に対し、粉末抽出エキス１重量部得られるものであ
る。(Extract of Turmeric Extract) 1 part by weight of dried turmeric root and stem was heat-extracted with 10 parts by weight of water as an extraction solvent, and concentrated by heating to obtain a powder extract. As a result, the extract which is heated and concentrated to form a powder is obtained by adding 1 part by weight of the powder extract to 5 parts by weight of the root and stem of the dried turmeric.
【００４３】（田七人参の抽出エキス）乾燥田七人参の
根１重量部に対し、抽出溶媒としての水１０重量部で加
熱抽出したものを加熱濃縮し、スプレードライにより粉
末抽出エキスとした。これにより加熱濃縮されて粉末と
なるエキスは、乾燥した田七人参の根５重量部に対し、
粉末抽出エキス１重量部得られるものである。(Extract of Radix Notoginseng) 1 part by weight of dried Radix Notoginseng root was heated and extracted with 10 parts by weight of water as an extraction solvent, followed by heating and concentration to obtain a powder extract by spray drying. As a result, the heat-concentrated powdery extract was added to 5 parts by weight of dried Radix Notoginseng root.
One part by weight of powder extract is obtained.
【００４４】（甘草のエキス）乾燥甘草の根１重量部に
対し、抽出溶媒としての水１０重量部で加熱抽出したも
のを加熱濃縮し、スプレードライにより粉末抽出エキス
とした。これにより加熱濃縮されて粉末となるエキス
は、乾燥した甘草の根７重量部に対し、粉末抽出エキス
１重量部得られるものである。(Licorice Extract) 1 part by weight of dried licorice root was heat-extracted with 10 parts by weight of water as an extraction solvent, followed by heating and concentration to obtain a powder-extracted extract by spray drying. As a result, the extract which is concentrated by heating to give a powder is obtained by adding 1 part by weight of the powder extract to 7 parts by weight of the dried licorice root.
【００４５】（紅参のエキス）乾燥紅参（根）重量部に
対し、抽出溶媒としてのエタノール／水の混合溶液（重
量比３０／７０）１０重量部で加熱抽出したものを加熱
濃縮し、スプレードライにより粉末抽出エキスとした。
これにより加熱濃縮されて粉末となるエキスは、乾燥し
た紅参（根）６重量部に対し、粉末抽出エキス１重量部
得られるものである。(Red ginseng extract) Heat-extracted with 10 parts by weight of a mixed solution of ethanol / water (weight ratio 30/70) as an extraction solvent based on parts by weight of dried red ginseng (root), and concentrated by heating, It was made into a powder extract by spray drying.
As a result, the extract which is heated and concentrated to give a powder is obtained by adding 1 part by weight of the powder extract to 6 parts by weight of dried red ginseng (root).
【００４６】（エビス草のエキス）乾燥エビス草の種子
１重量部に対し、抽出溶媒としてのエタノール／水の混
合溶液（重量比３０／７０）１０重量部で室温抽出した
ものを加熱濃縮し、スプレードライにより粉末抽出エキ
スとした。これにより加熱濃縮されて粉末となるエキス
は、乾燥したエビス草の種子１０重量部に対し、粉末抽
出エキス１重量部得られるものである。(Ebisu grass extract) 1 part by weight of dried ebisu grass seeds was extracted at room temperature with 10 parts by weight of a mixed solution of ethanol / water (weight ratio 30/70) as an extraction solvent, and concentrated by heating. It was made into a powder extract by spray drying. As a result, the extract which is heated and concentrated to give a powder is obtained by adding 1 part by weight of the powder extract to 10 parts by weight of dried seeds of Ebisu grass.
【００４７】得られた各抽出エキスを下記配合組成の配
合量となるように配合し、更に、賦形剤としてセルロー
ス及び乳糖をそれぞれ下記配合量となるように配合し、
下記配合組成（１）からなる組成物を得た。Each of the obtained extracts was blended so as to have the following blending composition, and further, cellulose and lactose as excipients were blended so as to have the following blending amounts, respectively,
A composition having the following composition (1) was obtained.
【００４８】 [0048]
【００４９】次に、上記の配合組成（１）からなる組成
物に水を加えて練りこみ、十分に混ぜ合わせる。これを
６０℃にて水分を蒸発させ乾燥した後、打錠して、一粒
あたり２５０ｍｇで三角形状の複数の粒からなる錠剤と
した。Next, water is added to the composition consisting of the above-mentioned composition (1), and the mixture is kneaded and thoroughly mixed. This was dried by evaporating water at 60 ° C., and then tableted to give a tablet having a plurality of triangular particles, 250 mg per tablet.
【００５０】〔試験例１〕日頃から倦怠感を感じている
４０歳以上の男性６人、女性４人の計１０人を被験者と
して、朝、昼、晩の１日３回、それぞれ食前に５粒ずつ
本錠剤を服用してもらい、１ヶ月後及び３ヶ月後の倦怠
感の改善効果についての試験を行なった。評価（倦怠感
改善効果の有効性）は、各被験者自身の判断に基づい
た。その結果を次に示す。[Test Example 1] Six males aged 40 and over and four females, who are feeling tired on a daily basis, were used as test subjects, a total of 10 subjects, three times a day in the morning, noon and evening, 5 times before meals. This tablet was taken grain by grain, and a test was conducted on the effect of improving fatigue after 1 month and 3 months. Evaluation (efficacy of fatigue improvement effect) was based on each subject's judgment. The results are shown below.
【００５１】 [0051]
【００５２】（実施例２）マリアアザミ、ウコン、田七
人参、甘草、及び紅参それぞれの抽出エキスを実施例１
と同様にして得ると共に、エビス草の乾燥粉末を下記の
ようにして得た。（エビス草の乾燥粉末）エビス草の粉
末については、６０℃で乾燥した乾燥エビス草の種子を
粉砕機にて粉砕し、細かい粉末状とする。これを、１０
０℃の温度をかけて滅菌し、エビス草の種子粉末とす
る。(Example 2) Extracts of the extract of Maria thistle, turmeric, seven fields of ginseng, licorice, and red ginseng were prepared in Example 1.
In the same manner as described above, a dry powder of shrimp grass was obtained as follows. (Dry powder of Ebisu grass) As for the powder of Ebisu grass, the dried Ebisu grass seeds dried at 60 ° C are crushed by a crusher to obtain a fine powder. This is 10
Sterilize at a temperature of 0 ° C. to obtain shrimp grass seed powder.
【００５３】得られた各抽出エキス及び乾燥粉末を、下
記配合組成の配合量となるように配合し、これに、更に
賦形剤としてセルロース及び乳糖をそれぞれ下記配合量
となるように配合し、下記配合組成（２）からなる組成
物を得た。The obtained extracts and dry powders were blended so as to have the blending amounts shown below, and cellulose and lactose as excipients were further blended at the following blending amounts, respectively. A composition having the following composition (2) was obtained.
【００５４】 [0054]
【００５５】上記の配合組成からなる組成物を、実施例
１と同様の条件で、水の練りこみ、加熱乾燥、打錠し
て、実施例１と同様の錠剤とした。The composition having the above composition was kneaded with water, heated and dried under the same conditions as in Example 1 to give tablets, which were the same as those in Example 1.
【００５６】〔試験例２〕医師の診断により肝機能の数
値がそれぞれ標準より悪いと診断された患者（男性７
人、女性３人の計１０人）に、朝、昼、夕方、及び就寝
前の１日４回、それぞれ５粒ずつ本錠剤を服用してもら
い、１ヶ月後、３ヶ月後及び６ヶ月後の肝機能の改善効
果についての試験を行なった。但し、患者は、全て医師
の処方による肝機能改善薬を使用していない者を選定し
た。評価（肝機能改善効果の有効性）は、肝機能の状態
を評価する上で基準となるＧＯＴ、ＧＰＴ、γ−ＧＴＰ
の各数値から医師による判断に基づいた。その結果を次
に示す。[Test Example 2] Patients (male 7
(10 people in total, 3 people and 3 women) take 5 tablets each in the morning, noon, evening and 4 times a day before bedtime, 1 month, 3 months and 6 months later. The effect of improving liver function was examined. However, patients were selected who were not using liver function improving drugs prescribed by doctors. The evaluation (effectiveness of the liver function improving effect) is GOT, GPT, γ-GTP which is a standard for evaluating the state of liver function.
Based on the judgment of the doctor from each value of. The results are shown below.
【００５７】 [0057]
【００５８】[0058]
【発明の効果】本発明の健康食品は、倦怠感を解消し、
肝機能を改善すると共に、肝機能障害の予防に有用なも
のである。The health food of the present invention eliminates malaise,
It is useful for improving liver function and preventing liver dysfunction.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.7 識別記号 ＦＩ テーマコート゛(参考） Ａ６１Ｋ 35/78 Ａ６１Ｋ 35/78 Ｔ 47/26 47/26 47/38 47/38 47/46 47/46 Ａ６１Ｐ 1/16 Ａ６１Ｐ 1/16 Ｆターム(参考） 4B018 LE01 LE02 LE03 LE05 MD61 MD63 ME02 ME14 MF01 MF06 MF08 4C076 AA36 BB01 CC16 DD67 EE31 EE38 EE58 FF04 4C088 AB16 AB26 AB59 AB60 AB81 AC01 AC04 AC05 AC11 BA09 BA10 MA07 MA35 MA52 ZA75─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. 7 Identification code FI theme code (reference) A61K 35/78 A61K 35/78 T 47/26 47/26 47/38 47/38 47/46 47/46 A61P 1/16 A61P 1/16 F term (reference) 4B018 LE01 LE02 LE03 LE05 MD61 MD63 ME02 ME14 MF01 MF06 MF08 4C076 AA36 BB01 CC16 DD67 EE31 EE38 EE58 FF04 4C088 AB16 AB26 AB59 AB60 AB81 AC01 AC04 AC05 AC11 MA09 BA09 MA75 MA11 BA09
Claims (5)
草、紅参、及びエビス草からなる６種の植物それぞれの
抽出物又は乾燥物を少なくとも含むことを特徴とする健
康食品。1. A health food comprising at least an extract or a dried product of each of 6 types of plants consisting of thistle, thistle, turmeric, seven fields of ginseng, licorice, red ginseng, and shrimp.
物それぞれの全体、種子、根又は茎の抽出エキス又は乾
燥粉末である、請求項１記載の健康食品。2. The health food according to claim 1, wherein the extract or dried product is an extract or a dry powder of whole, seed, root or stem of each of the 6 kinds of plants.
の種子、ウコンの根及び茎、田七人参の根、甘草の根、
紅参の全体、及びエビス草の種子それぞれの抽出エキス
又は乾燥粉末である、請求項２記載の健康食品。3. The extract or dried product comprises seeds of thistle, root and stem of turmeric, root of Radix Notoginseng, root of licorice,
The health food according to claim 2, which is an extract or a dry powder of the whole red ginseng and the seed of Ebisu grass.
くとも含み、該抽出物は、水、エタノール単体、又は水
とエタノールとの混合物よりなる抽出溶媒とする抽出エ
キスである、請求項１〜３の何れかに記載の健康食品。4. An extract containing at least an extract of each of the 6 types of plants, wherein the extract is an extract solvent comprising water, ethanol alone, or a mixture of water and ethanol. The health food according to any one of 3 above.
デキストリン及びパインデックスからなる群より選択さ
れる一種以上の賦形剤を更に含む錠剤である、請求項１
〜４の何れかに記載の健康食品。5. Cellulose, lactose, pine fiber,
The tablet, further comprising one or more excipients selected from the group consisting of dextrin and pa index.
The health food according to any one of to 4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001332458A JP2003135023A (en) | 2001-10-30 | 2001-10-30 | Health food |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001332458A JP2003135023A (en) | 2001-10-30 | 2001-10-30 | Health food |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2003135023A true JP2003135023A (en) | 2003-05-13 |
Family
ID=19147873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001332458A Pending JP2003135023A (en) | 2001-10-30 | 2001-10-30 | Health food |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2003135023A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007517829A (en) * | 2004-01-07 | 2007-07-05 | レーンデルト・タール | Plant extract composition |
| KR100892272B1 (en) | 2007-10-18 | 2009-04-09 | (주)아모레퍼시픽 | Dietary composition for enhancing atheletic continuous ability containing extracts of red ginseng and curcuma longa l |
| WO2009080006A2 (en) | 2007-12-23 | 2009-07-02 | Euromed Sa | Novel milk thistle extract, method for the production, and use |
-
2001
- 2001-10-30 JP JP2001332458A patent/JP2003135023A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007517829A (en) * | 2004-01-07 | 2007-07-05 | レーンデルト・タール | Plant extract composition |
| KR100892272B1 (en) | 2007-10-18 | 2009-04-09 | (주)아모레퍼시픽 | Dietary composition for enhancing atheletic continuous ability containing extracts of red ginseng and curcuma longa l |
| WO2009080006A2 (en) | 2007-12-23 | 2009-07-02 | Euromed Sa | Novel milk thistle extract, method for the production, and use |
| WO2009080006A3 (en) * | 2007-12-23 | 2009-10-08 | Euromed Sa | Novel milk thistle extract, method for the production, and use |
| JP2011507812A (en) * | 2007-12-23 | 2011-03-10 | エウロメッド エセアー | Novel milk thistle extract, preparation method and use |
| AU2008340922B2 (en) * | 2007-12-23 | 2012-07-19 | Euromed Sa | Novel milk thistle extract, method for the production, and use |
| EP2567703A3 (en) * | 2007-12-23 | 2013-03-20 | Euromed SA | Novel Silybum marianum extract, method of manufacture and use |
| RU2489161C2 (en) * | 2007-12-23 | 2013-08-10 | Эуромед Са | New milk thistle extract, method for preparing and using it |
| JP2014074051A (en) * | 2007-12-23 | 2014-04-24 | Euromed Sa | Novel milk thistle extract, method for preparation, and use |
| KR101607445B1 (en) | 2007-12-23 | 2016-03-29 | 유로메드 에스.에이. | Novel milk thistle extract, method for the production, and use |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2001514650A (en) | Essential oil composition | |
| CN105341415A (en) | Chinese herbal medicine additive for pig feed and preparation method of Chinese herbal medicine additive | |
| KR101855821B1 (en) | Composition for relieving of menopausal symptoms and improving blood circulation | |
| CN106359720A (en) | Health protection tea for clearing heat from throat and moistening lung and preparation method thereof | |
| CN106362020B (en) | A kind of pine pollen composition and preparation method thereof with improvement defecating feces excretion | |
| CN101569712B (en) | Chinese traditional medicine composition for treating cold | |
| KR100530211B1 (en) | Healthy and functional food composition for the improvement of the studying capability and its process | |
| Brendler et al. | Devil’s Claw (Harpagophytum procumbens DC) an evidence-based systematic review by the natural standard research collaboration | |
| KR20160000695A (en) | Herbal-medicine containing dha for recovering fatigue and enhancing memory, and method of manufacturing the same | |
| CN105943619A (en) | Application of whole hemp extract in preparation of drug for preventing and treating Alzheimer's disease | |
| CN101628053A (en) | Chinese herbal medicament used to treat painful swollen gum caused by intense stomach fire | |
| CN104922548A (en) | Chinese herbal preparation for treatment of ascariasis | |
| JP2003135023A (en) | Health food | |
| CN110721256B (en) | Traditional Chinese medicine composition for preventing and treating teniasis of laying hens and preparation method thereof | |
| CN107595954A (en) | A kind of Chinese medicine composition for reducing body fat and treating Central obesity and its application | |
| CN101816708B (en) | Chinese medicinal composition for curing rheumatism and preparation method thereof | |
| KR20100034528A (en) | A herb medicine gelly and method for preparing the same | |
| CN114533835B (en) | A Chinese medicinal composition with effects of removing pathogenic wind and dampness, and its preparation method | |
| CN103877513A (en) | Chinese herbal compound composition with blood fat reduction effect, and applications thereof | |
| CN104257839A (en) | Traditional Chinese medicine composition with effects of reducing blood glucose and blood fat and protecting vascular endothelium and preparation method thereof | |
| Nesari et al. | Fenugreek (Methika): Traditional Wisdom and Research Evidences | |
| CN112057535B (en) | Preparation method of traditional Chinese medicine composition for preventing or/and treating dyslipidemia | |
| JP2713549B2 (en) | Moisture-proof Chinese herbal preparation | |
| CN112057536B (en) | Traditional Chinese medicine composition for preventing or/and treating dyslipidemia and application thereof | |
| KR20050067592A (en) | Pharmaceutical composition for the improvement of the studying capability and its process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20041101 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20051128 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20051202 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20060324 |