JP2003113013A - Vegetable antimicrobial preservative - Google Patents

Vegetable antimicrobial preservative

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Publication number
JP2003113013A
JP2003113013A JP2001337101A JP2001337101A JP2003113013A JP 2003113013 A JP2003113013 A JP 2003113013A JP 2001337101 A JP2001337101 A JP 2001337101A JP 2001337101 A JP2001337101 A JP 2001337101A JP 2003113013 A JP2003113013 A JP 2003113013A
Authority
JP
Japan
Prior art keywords
composition
plant
antibacterial
microbial preservative
extract
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001337101A
Other languages
Japanese (ja)
Inventor
Yoshiko Ueda
佳子 上田
Hideo Sakai
秀雄 酒井
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lion Corp
Original Assignee
Lion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lion Corp filed Critical Lion Corp
Priority to JP2001337101A priority Critical patent/JP2003113013A/en
Publication of JP2003113013A publication Critical patent/JP2003113013A/en
Pending legal-status Critical Current

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  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Detergent Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

PROBLEM TO BE SOLVED: To provide a vegetable anti-microbial preservative which contains the extracts of one or more plants selected from 64 kinds of plants, and to provide an external preparation composition, an oral cavity preparation composition, a clothing agent composition, a kitchen agent composition and a dwelling agent composition which each contains the vegetable anti-microbial preservative. SOLUTION: This vegetable anti-microbial preservative has effective bactericidal and antibacterial forces against various bacteria and can widely sterilize microbes. Further, the vegetable anti-microbial preservative is highly safe for human bodies differently from synthetic microbicides on whose safety, environmental pollution and the like misgivings are felt, and can be applied to an extremely wide range, because not causing a trouble, even when left in a target article.

Description

【発明の詳細な説明】Detailed Description of the Invention

【０００１】[0001]

【発明の属する技術分野】本発明は、人体に対して極め
て安全性が高く、また広範囲の微生物に対して殺菌力を
示す、特定の植物より抽出された植物系の抗菌防腐剤、
及びそれを配合した外用組成物・口腔用組成物に関す
る。また、それを配合した衣料用、台所用、住居用組成
物に関する。TECHNICAL FIELD The present invention relates to a plant-based antibacterial preservative extracted from a specific plant, which is extremely safe for the human body and has bactericidal activity against a wide range of microorganisms.
And an external composition / oral composition containing the same. Further, the present invention relates to a composition for clothing, a kitchen, and a house in which it is mixed.

【０００２】[0002]

【従来の技術及び発明が解決しようとする課題】クリー
ムや乳液に使われる動物性油脂（ラノリン等）や石油系
油脂（流動パラフィン等）、ミツロウなどは水と練り合
わされて細菌やカビが繁殖したりカビが生えたりするの
に絶好の状態になっている。そこで、従来より、製造時
や使用時におけるそれら微生物による汚染や増殖を避け
製品の変質を防ぐために、様々な防腐剤や防カビ剤が使
用されてきた。多用されている殺菌防腐剤としては、安
息香酸及びその塩類、パラオキシ安息香酸エステル及び
その塩類、塩化ベンザルコニウム、ソルビン酸及びその
塩類、デヒドロ酢酸及びその塩類、プロピオン酸及びそ
の塩類、ジフェニル、オルトフェニルフェノール及びそ
の塩類、チアベンゾール、イマザリル、クロルクレゾー
ル、クロロブタノール、トリクロロヒドロキシジフェニ
ルエーテル（別名トリクロサン）、フェノール、ラウリ
ルジアミノエチルグリシンナトリウム、亜鉛・アンモニ
ア・銀複合置換型ゼオライト、グルコン酸クロルヘキシ
ジン、クレゾール、パラクロルフェノール、ハロカルバ
ン、ヒノキチオール、ピリチオン亜鉛、メチルクロロイ
ソチアゾリノン・メチルイソチアゾリノン液、Ｎ，Ｎ”
−メチレンビス［Ｎ’−（３−ヒドロキシメチル−２，
５−ジオキソ−４−イミダゾリジニル）ウレア、ヨウ化
パラジメチルアミノスチリルヘプチルメチルチアゾリウ
ムなどがあり、アルコール類、アルデヒド類、有機酸お
よび塩類、フェノール類、活性化ハロゲン化合物、第４
級アンモニウム塩類などに大まかに分類される。これら
の薬剤の作用には、膜作用と求電子作用とがある。膜作
用としては、アルコール類、フェノール類、有機酸類、
第４級アンモニウム塩類、グアニジン、アニリドなどが
あり、それらの作用は細胞膜への非特異的吸着、タンパ
ク質機能の阻害、膜の半透膜性の欠除、ＡＴＰ合成阻害
などである。また、求電子作用を持つ薬剤はアルデヒド
類、活性ハロゲン化物、イソチアゾリノン、水銀化合物
などがあり、これらは求核性の官能基と反応し、生命活
動に必要な酵素や基質を不活化することによって抗菌性
を示す。この作用を利用して、各種製品を菌汚染による
変質などから守るための防腐剤として使われている。2. Description of the Related Art Animal oils and fats (lanolin etc.) and petroleum oils (liquid paraffin etc.) and beeswax, etc. used in creams and emulsions are kneaded with water and bacteria and mold propagate. It is in a perfect condition for mold to grow. Therefore, conventionally, various preservatives and fungicides have been used in order to prevent contamination and growth of these microorganisms during production and use and prevent alteration of the product. As the bactericidal preservatives that are frequently used, benzoic acid and its salts, paraoxybenzoic acid ester and its salts, benzalkonium chloride, sorbic acid and its salts, dehydroacetic acid and its salts, propionic acid and its salts, diphenyl, ortho Phenylphenol and its salts, thiabenzol, imazalil, chlorcresol, chlorobutanol, trichlorohydroxydiphenyl ether (also known as triclosan), phenol, sodium lauryldiaminoethylglycine sodium, zinc / ammonia / silver composite substitution type zeolite, chlorhexidine gluconate, cresol, para Chlorphenol, halocarban, hinokitiol, zinc pyrithione, methylchloroisothiazolinone / methylisothiazolinone liquid, N, N "
-Methylenebis [N '-(3-hydroxymethyl-2,
5-dioxo-4-imidazolidinyl) urea, paradimethylaminostyrylheptylmethylthiazolium iodide and the like, alcohols, aldehydes, organic acids and salts, phenols, activated halogen compounds,
It is roughly classified into grade ammonium salts. The action of these drugs includes a membrane action and an electrophilic action. Membrane action includes alcohols, phenols, organic acids,
There are quaternary ammonium salts, guanidine, anilide and the like, and their actions are non-specific adsorption to cell membrane, inhibition of protein function, elimination of semipermeable membrane, inhibition of ATP synthesis and the like. In addition, drugs with electrophilic action include aldehydes, active halides, isothiazolinones, and mercury compounds, which react with nucleophilic functional groups to inactivate enzymes and substrates necessary for life activity. Shows antibacterial properties. Utilizing this action, it is used as an antiseptic to protect various products from deterioration due to bacterial contamination.

【０００３】また近年、食中毒病原菌Ｏ−１５７の流行
や多剤耐性菌ＭＲＳＡによる病院内感染などが問題とな
り、我々の身の回りに対する清潔意識が高まり、身体に
使用される製品だけでなく、衣・食・住における細菌除
去を目的とした製品が多く上市されている。これらの製
品において抗菌殺菌を担う成分として、製品防腐と同様
の殺菌剤、抗菌剤が使われている。In recent years, the epidemic of food poisoning pathogenic bacterium O-157 and the infection in hospitals caused by multidrug-resistant bacterium MRSA have become problems, and our awareness of cleanliness around us has increased, and not only products used for the body but also clothing and food.・ Many products for the purpose of removing bacteria in the market are on the market. As a component responsible for antibacterial sterilization in these products, bactericides and antibacterial agents similar to those used for product preserving are used.

【０００４】しかし、これらの殺菌防腐剤は微生物とい
う細胞を攻撃して傷害を与え、増殖を抑えたり、殺菌し
たりするのであるから、人体に対して何らかの影響があ
ることは考えられる。実際、薬剤によっては、皮膚刺激
やアレルギー反応などが報告されていたり、構造上、環
境ホルモン様作用が危惧されているものが多く、安全性
の高い殺菌防腐剤開発が重要な課題となっている。However, since these bactericidal preservatives attack cells called microorganisms to cause damage, suppress growth and sterilize, it is considered that they have some influence on the human body. In fact, some drugs have been reported to cause skin irritation or allergic reactions, or structurally endanger the environmental hormone-like action, so the development of a highly safe bactericidal preservative has become an important issue. .

【０００５】これに対し、安全性、低環境負荷を考慮し
て植物由来の成分による殺菌防腐も提案されてきた。植
物成分には抗菌活性を有するものが多く、その活性を利
用して、種々の感染症に対する医薬品として、また、に
きび、フケ、口腔細菌感染などに対する外用剤として幅
広く使われてきた。例えば、抗菌性植物抽出物と皮膚外
用剤への応用（特開２０００−４４４１９）、抗菌性化
粧料組成物（特開２０００−６３２６２）、抗菌剤とそ
れを含む皮膚外用剤及び皮膚洗浄剤（特開平１１−３２
２６３０）、殺菌性歯磨き（特表平１０−５０３１９
６）、口腔用組成物（特開平０４−１５９２１３）、ニ
キビ用皮膚外用剤（特開平０４−８２８３０）、歯周病
予防組成物（特開平０３−２５５０３１）、フケ菌発育
阻害剤を含有する皮膚・頭皮・頭髪用化粧料（特開平０
３−１７６４１３）、う蝕予防剤（特開平０１−１５１
５１２）など多くが提案されているが、製品防腐効果の
十分なものは見当たらない。On the other hand, in consideration of safety and low environmental load, sterilization and antiseptic using a plant-derived component has been proposed. Many plant components have antibacterial activity, and by utilizing the activity, they have been widely used as pharmaceuticals against various infectious diseases, and as external preparations against acne, dandruff, oral bacterial infections and the like. For example, application to an antibacterial plant extract and a skin external preparation (JP-A 2000-44419), an antibacterial cosmetic composition (JP-A 2000-63262), an antibacterial agent and a skin external preparation and a skin cleanser containing the same ( Japanese Patent Laid-Open No. 11-32
2630), bactericidal toothpaste (Table 10-50319)
6), a composition for oral cavity (JP-A 04-159213), an external skin preparation for acne (JP-A 04-82830), a periodontal disease preventive composition (JP-A 03-255031), and a dandruff growth inhibitor Cosmetics for skin, scalp and hair
3-176413), a caries preventive agent (JP-A-01-151)
512) and many others have been proposed, but none of them have sufficient antiseptic effects.

【０００６】また、生活周りの殺菌、抗菌に使用するこ
とについて、例えば、薄荷油、レモン油を配合した洗剤
組成物（特開平０３−１２４９９）、ローヤルゼリーと
重薬を含有する洗浄剤（特開平０４−１１７５００）、
植物エキスを吸着させたすすぎ剤（特開平０４−８２９
６６）、アスパラサス・リネアリス抽出物を有効成分と
する洗浄剤（特開平０６−９９９１）、ヒノキ油などを
配合した抗菌性薬用洗浄剤（特開平０６−２５６７９
２、特開２０００−３２８０９６）、ヨモギ属、ヒノキ
属の抽出物を含有する洗濯用仕上げ剤（特開平０８−４
９１７２）、生薬を利用した歯ブラシ専用洗浄剤（特開
平０９−１５７６９４）、カテキン誘導体を必須成分と
する除菌洗浄剤（特開平１０−２７３６９８）、甘草抽
出物を含有する殺菌・消臭清浄剤組成物（特開平１１−
１８９７９２）、ユッカフオーム抽出物を配合する除菌
洗浄剤（特開２００１−１１４９６）、杉、桧、ヒバの
抽出物を含有する住宅建材用洗浄剤（特開２００１−８
１４９７）など多く提案されているが、実効の明確なも
のは見当たらない。Regarding the use in sterilization and antibacterial activities in daily life, for example, a detergent composition containing light oil and lemon oil (Japanese Patent Laid-Open No. 03-12499), a cleaning agent containing royal jelly and heavy drugs (Japanese Patent Laid-Open No. 04-117500),
Rinse agent to which plant extract is adsorbed (Japanese Patent Application Laid-Open No. 04-829
66), a detergent containing an Aspalathus linealis extract as an active ingredient (JP-A 06-9991), and an antibacterial medicinal detergent containing cypress oil (JP-A 06-25679).
2, JP-A-2000-328096), a laundry finishing agent containing extracts of Artemisia and Cypress (JP-A-08-4).
9172), a cleaning agent for toothbrushes using crude drugs (JP-A-09-157694), a disinfectant cleaner containing a catechin derivative as an essential component (JP-A-10-273698), and a bactericidal / deodorant cleaner containing a licorice extract Composition (JP-A-11-
189792), a disinfecting detergent containing a Yucca foam extract (JP 2001-11496A), and a detergent for a house building material containing an extract of cedar, Japanese cypress, and hiba (JP 2001-8).
1497) and many others have been proposed, but none of them have a clear effect.

【０００７】[0007]

【課題を解決するための手段及び発明の実施の形態】本
発明者らは、種々の天然物、特に古来より経験的に菌感
染症に使用されてきた植物抽出物を対象に種々の製品汚
染菌に対する防腐力試験を実施した結果、特定の植物抽
出物が、外用組成物や口腔用組成物の製剤安定性や使用
感に影響を与えることなく有効な防腐作用を有し、尚且
つ皮膚や口腔内に刺激感を与えないことを見出し、本発
明の植物性抗菌防腐剤を完成するに至った。これを配合
した外用剤（皮膚化粧料、頭髪用化粧料、目薬、ハップ
剤）や口腔用組成物（歯磨剤、洗口剤）は従来の合成防
腐剤を配合した製品と比べて人体に対する安全性が高
い。Means for Solving the Problems and Modes for Carrying Out the Invention The present inventors target various natural products, particularly plant extracts that have been empirically used for fungal infections since ancient times, and various product contaminations. As a result of carrying out the antiseptic test against bacteria, the specific plant extract has an effective antiseptic effect without affecting the formulation stability or the feeling of use of the external composition or the oral composition, and the skin and It has been found that it does not give a feeling of irritation to the oral cavity, and the plant antibacterial preservative of the present invention has been completed. External formulations (skin cosmetics, hair cosmetics, eye drops, HAPs) and oral compositions (dentifrices, mouthwashes) containing this are safer for humans than products containing conventional synthetic preservatives. It is highly likely.

【０００８】また、本発明の植物性抗菌防腐剤が有する
優れた抗菌力は、衣類や家具、水周りなどに付着する菌
に対する有用な殺菌抗菌効果を示すことを見いだし、本
発明を完成するに至った。Further, it was found that the excellent antibacterial activity of the plant antibacterial preservative of the present invention has a useful bactericidal and antibacterial effect against bacteria attached to clothes, furniture, water and the like, and the present invention is completed. I arrived.

【０００９】即ち、本発明は、イヌエンジュ、ウワウル
シ、エキナセア、コガネバナ、キハダ、オウレン、オー
ルスパイス、オレガノ、エンジュ、カミツレ、スイカズ
ラ、クララ、ケイガイ、ケイ、ゲッケイジュ、ホオノ
キ、ゴボウ、コンフリー、ジャショウ、ワレモコウ、シ
ュクシャ、ショウガ、セイタカアワダチソウ、セイヨウ
ニワトコ、セージ、ヤドリギ、ホソバオケラ、タイム、
ハナスゲ、チョウジ、ウンシュウミカン、ティーツリ
ー、バーベリー、ドクダミ、ナンテン、ニュウコウ、ヨ
ロイグサ、シロガヤ、ボウフウ、オランダヒユ、ホッ
プ、ホンシタン、マウンテングレープ、ムラサキタガヤ
サン、セイヨウヤマハッカ、ヒオウギ、ヤマジソ、ユー
カリ、ラベンダー、ローズ、ローズマリー、バラン、ス
ギ、ギレアドバルサムノキ、ハクセン、ハハキギ、ミチ
ヤナギ、ジンギョウ、フウ、ツリガネニンジン、ハマビ
シ、ヤブガラシ、カンゾウ、セイヨウオトギリソウから
なる群より選ばれた一種又は二種以上の植物抽出物を含
有する植物性抗菌防腐剤とそれを配合する外用組成物、
口腔用組成物、さらに衣料用，台所用，住居用組成物を
提供するものである。[0009] That is, the present invention relates to Acacia nilotica, Acacia catechu, Echinacea, Scutellaria baicalensis, Yellowfin, Coptis, Allspice, Oregano, Enju, Chamomile, Honeysuckle, Clara, Caigai, kei, bay cabbage, honoki, burdock, comfrey, ginger, waremokou. , Shuksha, Ginger, Solidago virginii, Sambucus nigra, sage, mistletoe, prickly pear, thyme,
Butterflies, cloves, unripe mandarin oranges, tea tree, barberries, syringa, nanteng, euglena, syringa, sycamore, bowfowl, calla lily, hops, honshitan, mountain grapes, murasakitagayasan, seiyamahakka, halibut, yamajiso, eucalyptus, lavender, rose, rose A plant containing one or more plant extracts selected from the group consisting of marie, balun, cedar, Gilead balsamberry, Hakusen, Hahagi, Miscanthus, Bindweed, Fuu, Tulip ginseng, Cucumber, Pepper, licorice and St. John's wort. Antibacterial preservative and external composition containing the same,
It is intended to provide a composition for oral cavity, a composition for clothing, a kitchen, and a residence.

【００１０】以下、本発明につき更に詳しく説明する。
本発明に用いられる植物はその用部に特に限定はない
が、イヌエンジュは樹皮、ウワウルシは葉、エキナセア
は根、根茎、コガネバナは根（黄ごん）、キハダは樹皮
（黄柏）、オウレンは根茎（黄連）、オールスパイスは
果実、オレガノは地上部、エンジュは花蕾（槐花）、カ
ミツレは花、スイカズラは花蕾（金銀花）、クララは根
（苦参）、ケイガイは花穂（荊芥）、葉茎、ケイは枝、
樹皮（桂皮）、ゲッケイジュは葉、ホオノキは樹皮（厚
朴）、ゴボウは根、種子（牛蒡子）、コンフリーは葉、
根、ジャショウは種子（蛇床子）、ワレモコウは根、根
茎（地楡）、シュクシャは果実（縮砂）、ショウガは根
茎（生姜）、セイタカアワダチソウは花蕾、葉茎、根
茎、セイヨウニワトコは花、果実、葉、セージは葉茎、
ヤドリギは枝葉（桑寄生）、ホソバオケラは根茎
（朮）、タイムは地上部、ハナスゲは根茎（知母）、チ
ョウジは花蕾（丁香）、ウンシュウミカンは果皮（陳
皮）、ティーツリーは葉、バーベリーは樹皮、果実、ド
クダミは地上部（重薬）、ナンテンは果実、枝、ニュウ
コウは樹脂（乳香）、ヨロイグサは根（白し）、シロガ
ヤは根茎（茅根）、ボウフウは根（防風）、オランダヒ
ユは果実（補骨脂）、ホップは花穂、ホンシタンは材、
マウンテングレープは根、根茎、ムラサキタガヤサンは
材、セイヨウヤマハッカは地上部、ヒオウギは根茎（射
干）、ヤマジソは地上部、ユーカリは葉、ラベンダーは
花穂、ローズは花、ローズマリーは地上部、バランは根
（板藍根）、葉（大青葉）、スギは樹皮（杉皮）、ギレ
アドバルサムノキは葉芽、ハクセンは根皮（白鮮皮）、
ハハキギは果実（地膚子）、ミチヤナギは地上部（扁
蓄）、ジンギョウは根（秦ぎょう）、フウは果実（路路
通）、ツリガネニンジンは根（沙参）、ハマビシは果実
（しつり子）、ヤブガラシは地上部、カンゾウは根、根
茎（甘草）、セイヨウオトギリソウは地上部を用いるこ
とが好適である。The present invention will be described in more detail below.
The plant used in the present invention is not particularly limited in its part, but the bark of Inenju, the leaf of Erythrium, the root and rhizome of Echinacea, the root (yellow rice) of Scutellaria, the bark (yellow oak) of yellowfin, and the rhizome of laurel (Yelen), Allspice is fruit, Oregano is above ground, Enju is flower bud (Sophora), Chamomile is a flower, Honeysuckle is a flower bud (Gold and silver flower), Clara is a root (Bitterflower), Keigai is a flower ear (Madachi), Leaf stem, cay is a branch,
Bark (cinnamon bark), bay leaves are leaves, honoki is bark (bark), burdock roots, seeds (burdock root), comfrey leaves,
Roots, jasshoes are seeds (Pleurotus cornucopiae), waremoko are roots, rhizomes (ground mud), sukusha are fruits (condensed sand), ginger is rhizomes (ginger), honeywort is flower buds, leaves, rhizomes, and elderflowers are flowers, Fruits, leaves and sage are stems,
Mistletoe branches and leaves (mulberry parasitism), Hosobaokera rhizomes (blurred), thyme is aboveground, Hanasuge rhizomes (chimbo), cloves flower buds (clove), unshiu mandarin peel (leaf peel), tea tree leaves, barberry Bark, fruit, Dokudami are above-ground parts (heavy drug), Nanten is fruit, branch, Nyukou is resin (frankincense), Yellow primrose is root (white), Shirogaya is rhizome (kaya root), Bofufu is root (windproof), and Dutch sardine is Fruit (bone fat), hops for spikes, honshitan for timber,
Mountain grapes are roots, rhizomes, orchids for murasakita, wood is for yamahaka, above-ground is for rhizome, sycamore is foreground, yamiso is foreground, eucalyptus is for leaves, lavender is spikes, rose is for flowers, rosemary is foreground, balun is for balun. Roots (plank roots), leaves (large green leaves), cedar bark (cedar bark), Gilead balsam leaf buds, Hakusen root bark (white skin),
Hahakigi is a fruit (ground silk), Michiyanagi is above-ground (flat), Jingyo is root (Hatagyo), Fu is a fruit (road alley), Trifolium ginseng is a root (Sasan), and Habushi is a fruit (Shisuriri). It is preferable to use the above-ground part for pups and capsicum, the root and rhizome (liquorice) for liquorice, and the above-ground part for Hypericum perforatum.

【００１１】これらを生のままあるいは乾燥したものを
適当な大きさに切断したり、粉砕加工したものを抽出し
て、それらの抽出エキスあるいは成分を分離精製したも
のとして用いることができる。抽出は、常法による溶媒
抽出することによって得ることができ、抽出溶媒が使用
上無害のものであれば抽出液をそのまま用いても、適宜
な溶媒で希釈した希釈液として用いてもよく、あるいは
濃縮エキスとしたり、凍結乾燥などにより乾燥粉末とし
たり、ペースト状に調製したものなどが利用できる。[0011] Raw or dried ones of these may be cut into a suitable size, or may be crushed and extracted, and the extracted extracts or components may be used as separated and purified. The extraction can be obtained by solvent extraction according to a conventional method, and if the extraction solvent is harmless in use, the extract may be used as it is, or may be used as a diluted solution diluted with an appropriate solvent, or It can be used as a concentrated extract, as a dry powder by freeze-drying, or as a paste.

【００１２】上記植物の抽出物を得るのに用いる溶媒と
しては、メタノール、エタノール、ブタノール、ヘキサ
ン、ヘプタン、シクロヘキサン、酢酸エチル、アセト
ン、モノテルペン類などの一般に用いられる有機溶媒、
グリセリン、１，３−ブチレングリコール、ジプロピレ
ングリコール、プロピレングリコールなどのグリコール
類及び水などを挙げることができ、これらの１種を単独
で又は２種以上を混合して使用することができる。これ
らの溶媒の中では特にエタノール、水、１，３−ブチレ
ングリコール、モノテルペン類およびこれらの混合溶剤
が好ましい。なお、抽出処理は、冷浸、温浸、加熱還
流、パーコレーション法などの常法によって行うことが
できる。溶媒抽出の他に、水蒸気蒸留、炭酸ガスを超臨
界状態にして行う超臨界抽出によって得たエキスも同様
に利用できる。超臨界抽出では、抽出助剤としてヘキサ
ン、エタノールなどを用いることもできる。それぞれの
植物を個別に抽出する他、数種の植物を予め混合した
後、抽出することもできる。また、抽出物の分離精製
は、抽出物を活性炭処理、液液分配、カラムクロマトグ
ラフィー、液体クロマトグラフィーなどで行うことがで
きる。As the solvent used for obtaining the above plant extract, commonly used organic solvents such as methanol, ethanol, butanol, hexane, heptane, cyclohexane, ethyl acetate, acetone and monoterpenes,
Examples thereof include glycols such as glycerin, 1,3-butylene glycol, dipropylene glycol, and propylene glycol, and water. These can be used alone or in admixture of two or more. Among these solvents, ethanol, water, 1,3-butylene glycol, monoterpenes and mixed solvents thereof are particularly preferable. The extraction treatment can be carried out by a conventional method such as cold soaking, warm soaking, heating reflux, percolation method and the like. In addition to the solvent extraction, an extract obtained by steam distillation or supercritical extraction in which carbon dioxide gas is placed in a supercritical state can be similarly used. In supercritical extraction, hexane, ethanol or the like can be used as an extraction aid. In addition to individually extracting each plant, it is also possible to extract after mixing several types of plants in advance. The extract can be separated and purified by treating the extract with activated carbon, liquid-liquid distribution, column chromatography, liquid chromatography and the like.

【００１３】本発明の外用組成物、口腔用組成物、ま
た、衣料用、台所用、住居用組成物には、上記のイヌエ
ンジュ、ウワウルシ、エキナセア、コガネバナ、キハ
ダ、オウレン、オールスパイス、オレガノ、エンジュ、
カミツレ、スイカズラ、クララ、ケイガイ、ケイ、ゲッ
ケイジュ、ホオノキ、ゴボウ、コンフリー、ジャショ
ウ、ワレモコウ、シュクシャ、ショウガ、セイタカアワ
ダチソウ、セイヨウニワトコ、セージ、ヤドリギ、ホソ
バオケラ、タイム、ハナスゲ、チョウジ、ウンシュウミ
カン、ティーツリー、バーベリー、ドクダミ、ナンテ
ン、ニュウコウ、ヨロイグサ、シロガヤ、ボウフウ、オ
ランダヒユ、ホップ、ホンシタン、マウンテングレー
プ、ムラサキタガヤサン、セイヨウヤマハッカ、ヒオウ
ギ、ヤマジソ、ユーカリ、ラベンダー、ローズ、ローズ
マリー、バラン、スギ、ギレアドバルサムノキ、ハクセ
ン、ハハキギ、ミチヤナギ、ジンギョウ、フウ、ツリガ
ネニンジン、ハマビシ、ヤブガラシ、カンゾウ、セイヨ
ウオトギリソウからなる群より選ばれた一種又は二種以
上の植物抽出物を必須成分として含有するものである。The composition for external use, the composition for oral cavity, the composition for clothes, the kitchen, and the house of the present invention include the above-mentioned Astragalus japonicus, Ouarushi, Echinacea, Scutellaria baicalensis, Yellowfin, Ouren, Allspice, Oregano, Enju. ,
Chamomile, honeysuckle, clara, kayga, kay, bay, honoki, burdock, comfrey, jassho, waremokou, shukusha, ginger, solid grass, hollywood, sage, mistletoe, knotweed, tree sprout, tree syrup , Barberry, Dokudami, Nanten, Nukou, Yorugusa, Shirogaya, Boufu, Dutch Amaranthus, hops, honshitan, Mountain Grape, Murata Kitagasan, Seiyamahakka, Hyougi, Yamajiso, Eucalyptus, Lavender, Rose, Rosemary, Balun, Japanese cedar, Gilead balsamuki , Hakusen, Hahakki, Michiyanagi, Snapdragon, Fuu, Rhododendron carnatus, Pleurotus cornucopiae, Pepper, licorice, Hypericum perforatum Those containing more selected one or two or more plant extract as an essential component.

【００１４】本発明の植物抽出物の配合量は、組成物の
用途、剤型等に応じて適宜選定されるが、通常、抽出溶
剤を除いた固形分に換算して０．００１〜１０重量％配
合するのがよい。好ましくは０．００５〜５重量％配合
するのがよい。配合量が０．００１重量％未満である
と、本発明の効果を発揮できない。また１０重量％を超
えるほど多量に用いる必要はない。The blending amount of the plant extract of the present invention is appropriately selected depending on the use of the composition, the dosage form and the like, but is usually 0.001 to 10 weight% in terms of solid content excluding the extraction solvent. It is better to blend in%. It is preferable to add 0.005 to 5% by weight. If the blending amount is less than 0.001% by weight, the effect of the present invention cannot be exhibited. Further, it is not necessary to use a large amount such as more than 10% by weight.

【００１５】本発明の植物性抗菌防腐剤は、皮膚・口腔
などの粘膜、毛髪などに適用され、例えば、クリーム、
ハンドクリーム、乳液、化粧水、ローション、石鹸、ハ
ンドソープ、ボディソープ、制汗剤、水虫薬、にきび治
療剤、手指消毒剤、美白剤、貼布剤、目薬などの皮膚外
用剤および皮膚化粧料、シャンプー、リンス、トニッ
ク、育毛剤などの毛髪化粧料、歯磨、洗口剤、歯肉マッ
サージクリームなどの口腔用組成物などとして調製する
ことができる。The plant antibacterial preservative of the present invention is applied to mucous membranes such as skin and oral cavity, hair, and the like, for example, cream,
Hand creams, emulsions, lotions, lotions, soaps, hand soaps, body soaps, antiperspirants, athlete's foot remedies, acne remedies, hand antiseptics, whitening agents, patches, eye drops, and other skin external preparations and skin cosmetics. It can be prepared as a hair cosmetic such as shampoo, rinse, tonic, hair restorer and the like, or oral composition such as toothpaste, mouthwash, gingival massage cream and the like.

【００１６】また、本発明の衣料用組成物は衣類や運動
靴の洗浄、柔軟化、漂白、糊付け、シワ防止、帯電防
止、撥水加工などに適用され、例えば衣類用合成洗剤、
衣類用中性洗剤、運動靴用洗剤、柔軟剤、漂白剤、リン
ス剤、撥水剤、帯電防止剤などとして調製することがで
きる。台所用組成物は野菜や果物などの食品の洗浄、食
器やシンク、レンジ周りの洗浄、スポンジ、ふきんの洗
浄などに適用され、例えば野菜用洗剤、レンジ用洗剤、
自動食器洗浄機用洗剤などとして調製することができ
る。住居用組成物は、ガラス窓、床、畳、家具、水周り
の洗浄、室内の芳香などに適用され、例えばトイレ用洗
剤、浴室浴槽用洗剤、窓用洗剤、家具・床・畳用洗剤、
室内芳香消臭剤、エアコン用洗浄消臭剤などとして調製
することができる。The composition for clothing of the present invention is applied to washing clothes, sports shoes, softening, bleaching, gluing, anti-wrinkle, antistatic, water repellent treatment, and the like. For example, synthetic detergent for clothes,
It can be prepared as a neutral detergent for clothes, a detergent for sports shoes, a softening agent, a bleaching agent, a rinse agent, a water repellent, an antistatic agent and the like. The kitchen composition is applied to washing foods such as vegetables and fruits, washing dishes and sinks, washing around a microwave oven, sponge, washing cloth, and the like, for example, a vegetable detergent, a microwave detergent,
It can be prepared as a detergent for an automatic dishwasher. The residential composition is applied to glass windows, floors, tatami mats, furniture, cleaning around water, indoor aroma, and the like, for example, toilet detergent, bathroom bath detergent, window detergent, furniture / floor / tatami detergent,
It can be prepared as an indoor aroma deodorant, a cleaning deodorant for air conditioners and the like.

【００１７】この場合、本発明の外用剤、口腔用、衣料
用、台所用、住居用組成物は、上記組成物の種類、剤型
などに応じた公知の配合成分を用いて常法により調製で
きる。例えば、界面活性剤、油分、アルコール類、保湿
類、増粘剤、キレート剤、ｐＨ調整剤、香料、色素、紫
外線吸収剤・散乱剤、ビタミン類、アミノ酸類、水等を
必要に応じて適宜配合する事ができる。なお、任意成分
はこれらに限定されるものではない。また、本発明組成
物には、上記有効成分に加えて、一般に用いられている
抗菌剤、防腐剤、鮮度保持剤、保存剤、酸化防止剤など
をあわせて配合することができる。In this case, the composition for external use, oral cavity, clothing, kitchen and residential composition of the present invention is prepared by a conventional method using known compounding ingredients depending on the type and dosage form of the above composition. it can. For example, surfactants, oils, alcohols, moisturizers, thickeners, chelating agents, pH adjusters, fragrances, pigments, ultraviolet absorbers / scattering agents, vitamins, amino acids, water, etc., are appropriately added as necessary. Can be blended. The optional components are not limited to these. In addition to the above-mentioned active ingredients, the composition of the present invention may also contain generally used antibacterial agents, antiseptics, freshness-retaining agents, preservatives, antioxidants and the like.

【００１８】[0018]

【発明の効果】本発明の抗菌防腐剤は、種々の細菌に対
して有効な殺菌・抗菌力を持つ。これを配合した外用剤
は組成中に合成の防腐剤および抗菌剤（パラベンや安息
香酸塩類など）やアルコールを添加しなくとも製品の防
腐安定性を維持する事ができる。また、製品汚染菌のみ
ならず、微生物が関与する様々な不具合や疾患（にき
び、フケ、アトピー性皮膚炎、水虫、う食、歯周病、眼
病など）の予防または治療・改善作用なども期待でき
る。また、これを配合した衣料用組成物（洗剤、仕上げ
剤など）では被洗物のみならず洗濯機の除菌も可能であ
り、洗いあがりの衣類を抗菌処理することもできる。ま
た台所用洗浄剤では野菜や食器類、シンク、さらに、ま
な板、スポンジ、タワシ、布巾などの除菌、抗菌が可能
であり、住居用組成物では家具、窓や壁、風呂、トイ
レ、エアコンなどの洗浄剤、芳香剤、消臭剤などの空間
処理剤などとして、幅広い除菌、抗菌が可能である。ま
た安全性や環境汚染などが危惧される合成殺菌剤などと
は異なり、人体に対して安全性が高く、対象物に残留し
ても問題がないことから、応用範囲が極めて広いもので
ある。The antibacterial preservative of the present invention has effective bactericidal and antibacterial activity against various bacteria. The external preparation containing this can maintain the antiseptic stability of the product without adding synthetic antiseptics and antibacterial agents (paraben, benzoates, etc.) and alcohol in the composition. In addition to product-contaminating bacteria, it is also expected to prevent, treat, and improve various defects and diseases (acne, dandruff, atopic dermatitis, athlete's foot, caries, periodontal disease, eye diseases, etc.) related to microorganisms. it can. In addition, a composition for clothes (detergent, finishing agent, etc.) containing the same can be sterilized not only on the object to be washed but also on the washing machine, and the clothes after washing can be subjected to antibacterial treatment. In addition, kitchen cleaners can disinfect and antibacterial vegetables, tableware, sinks, cutting boards, sponges, scrubbing cloths, cloths, etc., and residential compositions can be used for furniture, windows and walls, baths, toilets, air conditioners, etc. A wide range of sterilization and antibacterial is possible as a space treatment agent such as cleaning agent, fragrance and deodorant. Further, unlike synthetic bactericides that may be concerned about safety and environmental pollution, it is highly safe for the human body and has no problem even if it remains on the object, so its application range is extremely wide.

【００１９】[0019]

〔調製例〕[Preparation example]

抽出エキスの調製：各植物を乾燥、粉砕して粗末とし、
各１０ｇをとり、シトロネロール／エタノール（１／
９）混液１００ｍＬに浸漬し室温で５日間抽出した。残
差をろ別して得られた抽出液を減圧濃縮し抽出エキスを
得た。ただし、ニュウコウは樹脂を同溶剤に溶解し、不
溶分をろ別し、抽出エキスとした。 〔実験例 殺菌力試験〕Preparation of extract: Dry and crush each plant to make coarse powder,
Take 10 g of each and add citronellol / ethanol (1 /
9) It was immersed in 100 mL of the mixed solution and extracted at room temperature for 5 days. The extract obtained by filtering the residual was concentrated under reduced pressure to obtain an extract. However, Nyukou was made into an extract by dissolving the resin in the same solvent and filtering the insoluble matter. [Experimental example: Sterilizing power test]

【００２０】各々の植物抽出物の殺菌力の測定は、以下
の方法で行った。供試菌として、大腸菌（Ｅｓｃｈｅｒ
ｉｃｈｉａ ｃｏｌｉ）、黄色ブドウ球菌（Ｓｔｐｈｙ
ｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）、緑濃菌（Ｐｓｅｕ
ｄｏｍｏｎａｓ ａｅｒｕｇｉｎｏｓａ）、製品汚染菌
として乳酸菌（Ｌａｃｔｏｂａｃｉｌｌｕｓ属）、酵母
（Ｃａｎｄｉｄａ、Ｐｉｃｈｉａ）、腸内細菌を用い
た。上記調製例で得た各々の植物抽出エキスをｐＨ７の
リン酸緩衝液に０．５重量％となるように添加し、次い
で前記供試菌を約１０８個／ｍＬとなるように植菌し攪
拌した。２０℃で反応させた後、それぞれの生菌数を測
定した。反応時間は、即効的な殺菌、やや緩効的な殺菌
（スポンジ、ふきんの除菌、洗濯時の漬けおきなどの除
菌）、防腐、をそれぞれ想定して、１０分、４時間、２
４時間で行なった。結果の判定基準は、生菌数が１０２
個／ｍＬ未満の場合を◎、１０２〜１０４個／ｍＬの場
合を○、１０４個／ｍＬ以上の場合を×として、反応時
間１０分の結果を表１〜２、反応時間４時間の結果を表
３〜４、反応時間２４時間の結果を表５〜６に示した。
尚、各植物の用部はすべて表１および表２に記載したも
のである。The bactericidal activity of each plant extract was measured by the following method. Escherichia coli (Escher)
ichia coli), Staphylococcus aureus (Stphy)
lococcus aureus), Pseudomonas aeruginosa
Domonas aeruginosa), lactic acid bacteria (Lactobacillus genus), yeasts (Candida, Pichia), and enterobacteria as product-contaminating bacteria were used. Each of the plant extracts obtained in the above Preparation Example was added to a phosphate buffer of pH 7 so as to be 0.5% by weight, and then the test bacteria were inoculated to a concentration of about 10 8 cells / mL. It was stirred. After reacting at 20 ° C., the number of each viable cell was measured. The reaction time is 10 minutes, 4 hours, and 2 minutes, assuming immediate sterilization, moderately slow sterilization (sterilization of sponges, wipes, pickling during washing, etc.) and preservation.
It took 4 hours. The criterion for the result is that the viable cell count is 10 2
The case where the number is less than 10 pieces / mL is ⊚, the case where 10 2 to 10 4 pieces / mL is ○, the case where 10 4 pieces / mL or more is x, the results of the reaction time of 10 minutes are shown in Tables 1-2 and the reaction time of 4 hours. The results are shown in Tables 3 to 4, and the results of the reaction time of 24 hours are shown in Tables 5 to 6.
The parts of each plant are as shown in Tables 1 and 2.

【００２１】[0021]

【表１】 [Table 1]

【００２２】[0022]

【表２】 [Table 2]

【００２３】[0023]

【表３】 [Table 3]

【００２４】[0024]

【表４】 [Table 4]

【００２５】[0025]

【表５】 [Table 5]

【００２６】[0026]

【表６】 [Table 6]

【００２７】表１〜６の結果から明らかなように、イヌ
エンジュ、ウワウルシ、エキナセア、コガネバナ、キハ
ダ、オウレン、オールスパイス、オレガノ、エンジュ、
カミツレ、スイカズラ、クララ、ケイガイ、ケイ、ゲッ
ケイジュ、ホオノキ、ゴボウ、コンフリー、ジャショ
ウ、ワレモコウ、シュクシャ、ショウガ、セイタカアワ
ダチソウ、セイヨウニワトコ、セージ、ヤドリギ、ホソ
バオケラ、タイム、ハナスゲ、チョウジ、ウンシュウミ
カン、ティーツリー、バーベリー、ドクダミ、ナンテ
ン、ニュウコウ、ヨロイグサ、シロガヤ、ボウフウ、オ
ランダヒユ、ホップ、ホンシタン、マウンテングレー
プ、ムラサキタガヤサン、セイヨウヤマハッカ、ヒオウ
ギ、ヤマジソ、ユーカリ、ラベンダー、ローズ、ローズ
マリー、バラン、スギ、ギレアドバルサムノキ、ハクセ
ン、ハハキギ、ミチヤナギ、ジンギョウ、フウ、ツリガ
ネニンジン、ハマビシ、ヤブガラシ、カンゾウ、セイヨ
ウオトギリソウに優れた殺菌効果が確認された。As is clear from the results shown in Tables 1 to 6, Inujou, Ouaraushi, Echinacea, Scutellaria baicalensis, Yellowfin, Ouren, Allspice, Oregano, Enju,
Chamomile, honeysuckle, clara, kayga, kay, bay, honoki, burdock, comfrey, jassho, waremokou, shukusha, ginger, solid grass, hollywood, sage, mistletoe, knotweed, tree sprout, tree syrup , Barberry, Dokudami, Nanten, Nukou, Yorugusa, Shirogaya, Boufu, Dutch Amaranthus, hops, honshitan, Mountain Grape, Murata Kitagasan, Seiyamahakka, Hyougi, Yamajiso, Eucalyptus, Lavender, Rose, Rosemary, Balun, Japanese cedar, Gilead balsamuki Excellent for, Chinese cabbage, Chinese cabbage, Hagakigi, Willow, Snapdragon, Fuu, Ginseng, Hamabishi, Pepper, licorice, Hypericum perforatum Bacteria effect was confirmed.

【００２８】以下、本発明の植物性抗菌防腐剤を配合し
た処方例を示す。尚、各植物エキスは調製例の抽出法に
より抽出したものを用いた。下記の例は、いずれも殺菌
抗菌効果に優れており、安定性、安全性も良好なもので
あった。The following are formulation examples containing the antimicrobial preservative of the present invention. Each plant extract used was extracted by the extraction method of Preparation Example. The following examples were all excellent in bactericidal antibacterial effect, and were also stable and safe.

【００２９】[0029]

【表７】 [Table 7]

【００３０】[0030]

【表８】 [Table 8]

【００３１】[0031]

【表９】 [Table 9]

【００３２】[0032]

【表１０】 [Table 10]

【００３３】[0033]

【表１１】 [Table 11]

【００３４】[0034]

【表１２】 [Table 12]

【００３５】[0035]

【表１３】 [Table 13]

【００３６】[0036]

【表１４】 [Table 14]

【００３７】[0037]

【表１５】 [Table 15]

【００３８】[0038]

【表１６】 [Table 16]

【００３９】[0039]

【表１７】 [Table 17]

【００４０】[0040]

【表１８】 [Table 18]

【００４１】[0041]

【表１９】 [Table 19]

【００４２】[0042]

【表２０】 [Table 20]

【００４３】[0043]

【表２１】 [Table 21]

【００４４】[0044]

【表２２】 [Table 22]

【００４５】[0045]

【表２３】 [Table 23]

【００４６】[0046]

【表２４】 [Table 24]

【００４７】[0047]

【表２５】 [Table 25]

【００４８】[0048]

【表２６】 [Table 26]

【００４９】[0049]

【表２７】 [Table 27]

【００５０】[0050]

【表２８】 [Table 28]

【００５１】[0051]

【表２９】 [Table 29]

【００５２】[0052]

【表３０】 [Table 30]

【００５３】[0053]

【表３１】 [Table 31]

【００５４】[0054]

【表３２】 [Table 32]

【００５５】[0055]

【表３３】 [Table 33]

【００５６】[0056]

【表３４】 [Table 34]

【００５７】[0057]

【表３５】 [Table 35]

【００５８】[0058]

【表３６】 [Table 36]

【００５９】[0059]

【表３７】 [Table 37]

【００６０】[0060]

【表３８】 [Table 38]

【００６１】[0061]

【表３９】 [Table 39]

【００６２】[0062]

【表４０】 [Table 40]

【００６３】[0063]

【表４１】 [Table 41]

【００６４】[0064]

【表４２】 [Table 42]

【００６５】[0065]

【表４３】 [Table 43]

【００６６】[0066]

【表４４】 [Table 44]

【００６７】[0067]

【表４５】 [Table 45]

【００６８】[0068]

【表４６】 [Table 46]

【００６９】[0069]

【表４７】 [Table 47]

【００７０】[0070]

【表４８】 [Table 48]

【００７１】[0071]

【表４９】 [Table 49]

【００７２】[0072]

【表５０】 [Table 50]

【００７３】[0073]

【表５１】 [Table 51]

───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.7 識別記号 ＦＩ テーマコート゛(参考） Ａ６１Ｋ 7/32 Ａ６１Ｋ 7/32 7/48 7/48 35/78 35/78 Ｗ Ａ６１Ｐ 17/16 Ａ６１Ｐ 17/16 Ｃ１１Ｄ 3/48 Ｃ１１Ｄ 3/48 Ｆターム(参考） 4C083 AA082 AA111 AA112 AA122 AB032 AB172 AB242 AB282 AB322 AB442 AC012 AC022 AC072 AC102 AC122 AC132 AC182 AC242 AC302 AC352 AC392 AC422 AC432 AC442 AC482 AC532 AC542 AC562 AC582 AC612 AC642 AC662 AC682 AC692 AC712 AC782 AC792 AC862 AC902 AD022 AD042 AD092 AD112 AD132 AD242 AD282 AD352 AD392 AD472 AD492 AD532 AD572 AD662 BB48 CC05 CC07 CC17 CC38 CC39 CC41 FF01 4C088 AB03 AB12 AB26 AB30 AB32 AB33 AB38 AB41 AB43 AB44 AB47 AB51 AB56 AB57 AB59 AB60 AB62 AB63 AB65 AB71 AB72 AB81 AB85 AC01 AC02 AC03 AC04 AC05 AC11 BA07 BA08 MA02 MA08 MA17 MA28 MA63 NA05 NA14 ZA89 4H003 AB03 AB09 AB10 DA01 DA05 DA17 EA19 EA21 EA25 EA27 EB04 EB05 EB08 EB16 EB24 EB36 EB37 EB40 EB41 EB42 EB43 ED02 FA01 FA34 4H011 AA02 BA01 BB22 BC03 BC18 DA13 DC05 DD07 ─────────────────────────────────────────────────── ─── Continued Front Page (51) Int.Cl. 7 Identification Code FI Theme Coat (Reference) A61K 7/32 A61K 7/32 7/48 7/48 35/78 35/78 W A61P 17/16 A61P 17 / 16 C11D 3/48 C11D 3/48 F term (reference) 4C083 AA082 AA111 AA112 AA122 AB032 AB172 AB242 AB282 AB322 AB442 AC012 AC022 AC072 AC102 AC122 AC132 AC182 AC242 AC302 AC352 AC392 AC422 AC432 AC692 AC482 AC532 AC542 AC562 AC582 AC612 AC642 AC642 AC712 AC782 AC792 AC862 AC902 AD022 AD042 AD092 AD112 AD132 AD242 AD282 AD352 AD392 AD472 AD492 AD532 AD572 AD662 BB48 CC05 CC07 CC17 CC38 CC39 CC41 FF01 4C088 AB03 AB12 AB26 AB30 AB32 AB33 AB38 AB41 AB43 AB44 AB47 AB51 AB56 AB72 AB63 AB60 AB62 AB72 AB59 AB60 AB85 AC01 AC02 AC03 AC04 AC05 AC11 BA07 BA08 MA02 MA08 MA17 MA28 MA63 NA05 NA14 ZA89 4H003 AB03 AB09 AB10 DA01 DA05 DA17 EA19 EA21 EA25 EA27 EB04 EB05 EB08 EB16 EB24 EB36 EB37 EB40 EB41 EB42 EB43 ED02 FA01 FA34 4H011 AA02 BA01 BB22 BC03 BC18 DA13 DC05 DD07

Claims (3)

【特許請求の範囲】[Claims] 【請求項１】イヌエンジュ、ウワウルシ、エキナセア、
コガネバナ、キハダ、オウレン、オールスパイス、オレ
ガノ、エンジュ、カミツレ、スイカズラ、クララ、ケイ
ガイ、ケイ、ゲッケイジュ、ホオノキ、ゴボウ、コンフ
リー、ジャショウ、ワレモコウ、シュクシャ、ショウ
ガ、セイタカアワダチソウ、セイヨウニワトコ、セー
ジ、ヤドリギ、ホソバオケラ、タイム、ハナスゲ、チョ
ウジ、ウンシュウミカン、ティーツリー、バーベリー、
ドクダミ、ナンテン、ニュウコウ、ヨロイグサ、シロガ
ヤ、ボウフウ、オランダヒユ、ホップ、ホンシタン、マ
ウンテングレープ、ムラサキタガヤサン、セイヨウヤマ
ハッカ、ヒオウギ、ヤマジソ、ユーカリ、ラベンダー、
ローズ、ローズマリー、バラン、スギ、ギレアドバルサ
ムノキ、ハクセン、ハハキギ、ミチヤナギ、ジンギョ
ウ、フウ、ツリガネニンジン、ハマビシ、ヤブガラシ、
カンゾウ、セイヨウオトギリソウからなる群より選ばれ
た一種又は二種以上の植物抽出物を含有する植物性抗菌
防腐剤。1. A yellow-tailed sardine, an oak, an echinacea,
Scutellaria, Yellowfin, Ouren, Allspice, Oregano, Enju, Chamomile, Honeysuckle, Clara, Keigai, Kay, Bay, Hogoki, Burdock, Comfrey, Jashou, Waremokou, Shuksha, Ginger, Seiko, St. John's wort, Seiko, Sage, Sage Hosobaokera, thyme, rapeseed, clove, unmanned orange, tea tree, barberry,
Dokudami, Nanten, Nyukou, Yorugusa, Shirogaya, Bowhuu, Dutch sardine, hop, honshitan, mountain grape, purple chisel, yamahaka, sugi, yamadiso, eucalyptus, lavender,
Rose, rosemary, balun, Japanese cedar, Gilead balsamberry, Chinese cabbage, Japanese cabbage, citrus willow, gentian, hu, lichen carrot, scabbard, tadpole,
A plant antibacterial preservative containing one or more plant extracts selected from the group consisting of liquorice and Hypericum perforatum. 【請求項２】請求項１記載の植物性抗菌防腐剤を含む外
用組成物、口腔用組成物。2. A composition for external use and a composition for oral cavity containing the plant antibacterial preservative according to claim 1. 【請求項３】請求項１記載の植物性抗菌防腐剤を含む衣
類用組成物、台所用組成物、住居用組成物。3. A composition for clothing, a composition for kitchen, a composition for residential use, which comprises the plant antimicrobial preservative according to claim 1.
JP2001337101A 2001-09-28 2001-09-28 Vegetable antimicrobial preservative Pending JP2003113013A (en)

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