JP2002501013A - Skin whitening composition - Google Patents
Skin whitening compositionInfo
- Publication number
- JP2002501013A JP2002501013A JP2000528264A JP2000528264A JP2002501013A JP 2002501013 A JP2002501013 A JP 2002501013A JP 2000528264 A JP2000528264 A JP 2000528264A JP 2000528264 A JP2000528264 A JP 2000528264A JP 2002501013 A JP2002501013 A JP 2002501013A
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- JP
- Japan
- Prior art keywords
- skin
- acid
- weight
- composition according
- metal salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
(57)【要約】 （Ａ）５−２５重量％の脂肪酸と、（Ｂ）０．１−１０重量％の脂肪酸セッケンと、（Ｃ）０．０５−１０重量％のα−ヒドロキシカルボン酸及び／またはα−アシルオキシカルボン酸のアルカリ金属塩またはアルカリ土類金属塩とから成るヒトの皮膚に外用塗布するための皮膚美白用化粧品組成物。 (57) [Summary] (A) 5-25% by weight of a fatty acid, (B) 0.1-10% by weight of a fatty acid soap, and (C) 0.05-10% by weight of an α-hydroxycarboxylic acid and / or an α-acyloxycarboxylic acid. A skin whitening cosmetic composition for external application to human skin comprising an alkali metal salt or an alkaline earth metal salt of an acid.
Description
【０００１】 本発明は皮膚美白用化粧品組成物に関する。本発明はまた、本発明の皮膚美白
用組成物を皮膚に外用塗布する方法に関する。The present invention relates to a cosmetic composition for whitening skin. The present invention also relates to a method for externally applying the skin lightening composition of the present invention to the skin.
【０００２】 メラミンは頭髪及び皮膚の黒色色素であり、アミノ酸チロシンからメラノゾー
ムによって合成される。メラノゾームはメラニン形成細胞中で検出される細胞内
器官であり、真皮と表皮の境界に存在する細胞の一種である。チロシンは酵素チ
ロシナーゼの作用を受け、これがメラニン形成の基本段階である。皮膚の色素沈
着を制御するためにヒドロキノンとその誘導体、カテコール、メルカプトアミン
、アルファヒドロキシ酸などのようなチロシナーゼ阻害物質を使用することは幾
つかの論文に報告されている。しかしながらこれらの物質のうちで、可逆性を有
しており且つ望ましくない副作用を示さないものは少ない。[0002] Melamine is a black pigment in hair and skin and is synthesized by the melanosome from the amino acid tyrosine. Melanosomes are intracellular organs detected in melanocytes and are a type of cells located at the border between the dermis and epidermis. Tyrosine is affected by the enzyme tyrosinase, which is the basic step in melanogenesis. The use of tyrosinase inhibitors such as hydroquinone and its derivatives, catechol, mercaptoamine, alpha hydroxy acids and the like to control skin pigmentation has been reported in several articles. However, few of these substances are reversible and do not exhibit undesirable side effects.
【０００３】 メラミンはメラノゾーム中でモノマーから合成され隣接のケラチン形成細胞に
移動する。ケラチン形成細胞は***及び分化し、その結果としてメラノゾームを
皮膚の表面に運搬する。皮膚の色の濃さはメラノゾームの数、大きさ及びメラミ
ン含量、メラノゾームの形成速度並びにケラチン形成細胞への移動速度に正比例
の関係を示す。[0003] Melamine is synthesized from monomers in melanosomes and migrates to adjacent keratinocytes. Keratinocytes divide and differentiate, and consequently carry melanosomes to the surface of the skin. Skin color intensity is directly proportional to the number, size and melamine content of melanosomes, the rate of melanosome formation and the rate of migration to keratinocytes.
【０００４】 従来の皮膚美白用組成物は日焼け防止剤または皮膚美白剤を基剤とする。皮膚
美白剤はメラノゾームの分散を抑制するかまたはチロシナーゼを阻害すると考え
られている。日焼け防止剤は単独では自然の色以上に皮膚を美白することはでき
ない。日焼け防止剤は周囲紫外線の皮膚侵入を軽減させる作用を有するだけであ
る。[0004] Conventional skin lightening compositions are based on sunscreen or skin lightening agents. Skin lightening agents are believed to inhibit melanosome dispersion or inhibit tyrosinase. Sunscreen alone cannot whiten the skin better than the natural color. Sunscreens only act to reduce the penetration of ambient UV radiation into the skin.
【０００５】 従って、日焼け防止剤は昼間しか効果を発揮できないという欠点があり、皮膚
美白剤として使用される化合物の幾つかは望ましくない副作用を有することが知
られている。[0005] Therefore, sunscreens have the disadvantage of being effective only during the day, and it is known that some of the compounds used as skin lightening agents have undesirable side effects.
【０００６】 皮膚の肌理を改善し、滑らかで健康で潤いのある皮膚を保つ、などの種々の有
益な効果を与える化粧用化合物中にα−ヒドロキシ酸を使用することは米国特許
ＵＳ５６５８５８０に報告されている。米国特許ＵＳ５２６２１５３は、乳酸と
その誘導体がチロシナーゼの形成を阻害することによってメラミン形成を抑制す
る作用をもつ有効な皮膚白化剤であることを開示している。The use of α-hydroxy acids in cosmetic compounds that provide various beneficial effects, such as improving skin texture and maintaining a smooth, healthy and moist skin, is reported in US Pat. No. 5,658,580. ing. U.S. Patent No. 5,262,153 discloses that lactic acid and its derivatives are effective skin whitening agents that have the effect of inhibiting melamine formation by inhibiting tyrosinase formation.
【０００７】 種々の有効物質を配給する化粧品組成物は種々の乳化系及びビヒクルを使用し
て調製されている。一般に脂肪酸とアルカリ金属セッケンとから成るバニシング
クリーム基剤は、望ましいマットな感触を皮膚に与えるので、化粧品に許容され
るビヒクルの好ましい形態の１つである。しかしながら残念なことに、皮膚美白
剤として知られている乳酸は、バニシングクリームのｐＨを実質的に低下させ基
剤を不安定にするので、バニシングクリーム中で使用することができない。[0007] Cosmetic compositions delivering various active substances have been prepared using various emulsifying systems and vehicles. Vanishing cream bases, which generally consist of fatty acids and alkali metal soaps, are one of the preferred forms of vehicles that are cosmetically acceptable, as they impart the desired matte feel to the skin. Unfortunately, however, lactic acid, which is known as a skin lightening agent, cannot be used in burnishing creams because it substantially lowers the pH of the burnishing cream and makes the base unstable.
【０００８】 α−ヒドロキシ及びα−アシルオキシ−カルボン酸のアルカリ金属塩及びアル
カリ土類金属塩もまた皮膚美白効果を有しており、しかもこれらの塩はバニシン
グクリーム基剤中で皮膚に有効に配給されるという利点をもつことがここに知見
された。[0008] Alkali metal and alkaline earth metal salts of α-hydroxy and α-acyloxy-carboxylic acids also have skin lightening effects, and these salts are effectively distributed to the skin in a vanishing cream base. It has been found here that it has the advantage of being
【０００９】 従って本発明の目的は、皮膚美白効果を得るためにバニシングクリーム基剤に
よって乳酸及びその誘導体を皮膚に配給する化粧品組成物を提供することである
。[0009] Accordingly, it is an object of the present invention to provide a cosmetic composition for delivering lactic acid and its derivatives to the skin with a vanishing cream base to obtain a skin whitening effect.
【００１０】 即ち本発明は、 （Ａ）５−２５重量％のＣ１２−Ｃ２０脂肪酸と、 （Ｂ）０．１−１０重量％の脂肪酸セッケンと、 （Ｃ）０．０５−１０重量％のα−ヒドロキシカルボン酸及び／またはα−アシ
ルオキシカルボン酸のアルカリ金属塩またはアルカリ土類金属塩と、 から成るヒトの皮膚に外用塗布するための皮膚美白用化粧品組成物に関する。That is, the present invention provides (A) 5 to 25% by weight of a C12-C20 fatty acid, (B) 0.1 to 10% by weight of a fatty acid soap, and (C) 0.05 to 10% by weight of α. An alkali metal salt or an alkaline earth metal salt of a hydroxycarboxylic acid and / or an α-acyloxycarboxylic acid, and a skin whitening cosmetic composition for external application to human skin.
【００１１】 本発明組成物によって得られる皮膚美白効果は可逆性であり、副作用を全く生
じない。本発明組成物は日中も夜間も活性である。The skin lightening effect obtained by the composition according to the invention is reversible and does not cause any side effects. The compositions of the present invention are active during the day and at night.
【００１２】 好ましくはアルカリ金属塩またはアルカリ土類金属塩が乳酸の塩及び／または
アシルオキシラクチレートの塩である。最も好ましくは塩がステロイルラクチレ
ートの塩である。Preferably, the alkali metal salt or alkaline earth metal salt is a salt of lactic acid and / or a salt of acyloxylactylate. Most preferably, the salt is a salt of steroyl lactylate.
【００１３】 本発明のより好ましい特徴によれば、化粧品組成物が少なくとも０．０５重量
％のステロイルラクチレートのアルカリ金属塩を含む。According to a more preferred feature of the present invention, the cosmetic composition comprises at least 0.05% by weight of an alkali metal salt of steryl lactylate.
【００１４】 α−ヒドロキシカルボン酸及び／またはα−アシルオキシカルボン酸の特に好
適な塩はナトリウム塩である。Particularly preferred salts of α-hydroxycarboxylic acids and / or α-acyloxycarboxylic acids are the sodium salts.
【００１５】 組成物は好ましくは１０−２０重量％のＣ１２−Ｃ２０脂肪酸を含む。[0015] The composition preferably comprises 10-20% by weight of C12-C20 fatty acids.
【００１６】 組成物はより好ましくはＣ１４−１８脂肪酸を含む。脂肪酸セッケンは組成物
の１−５重量％を構成する。脂肪酸及び脂肪酸誘導体は好ましくは飽和形態であ
る。[0016] The composition more preferably comprises a C14-18 fatty acid. Fatty acid soaps make up 1-5% by weight of the composition. Fatty acids and fatty acid derivatives are preferably in saturated form.
【００１７】 本発明の別の特徴によれば、本発明の皮膚美白用組成物を皮膚に外用塗布する
皮膚美白用化粧方法が提供される。According to another aspect of the present invention, there is provided a skin whitening cosmetic method for externally applying the skin whitening composition of the present invention to skin.
【００１８】 組成物は更に追加の皮膚美白剤を含有し得る。これらは、例えばナイアシン、
ナイアシンアミド、胎盤エキス、ヒドロキノンとその誘導体（例えばアルブチン
）、コウジ酸、式ＨＯＯＣ−（ＣxＨy）−ＣＯＯＨ〔式中、ｘは４−２０、ｙは
６−４０の範囲の数を表す〕で示されるジカルボン酸（アゼライン酸、セバシン
酸）、アスコルビン酸とその誘導体、及びフェルラ酸のような公知の任意の物質
から選択され得る。別の皮膚美白剤としては、レチノールとその誘導体、有機日
焼け防止剤、例えば４−ｔｅｒｔ−ブチル−４′−メトキシジベンゾイルメタン
及び／または２−エチルヘキシルメトキシルシンナメート、無機日焼け防止剤、
例えば微粉形態の二酸化チタン、酸化亜鉛、または、ＵＶＡ遮断剤及びＵＶＢ遮
断剤、その他の公知の皮膚美白用化合物がある。好ましい皮膚美白剤はナイアシ
ン及びナイアシンアミドである。組成物は追加の皮膚美白剤を０−１０重量％の
量で含有し得る。[0018] The composition may further comprise an additional skin lightening agent. These are, for example, niacin,
Niacinamide, placental extract, hydroquinone and its derivatives (eg, arbutin), kojic acid, formula HOOC- (C x H y ) -COOH wherein x represents a number in the range of 4-20 and y represents a number in the range of 6-40 (Azelaic acid, sebacic acid), ascorbic acid and its derivatives, and ferulic acid. Other skin lightening agents include retinol and its derivatives, organic sunscreens such as 4-tert-butyl-4'-methoxydibenzoylmethane and / or 2-ethylhexylmethoxyl cinnamate, inorganic sunscreens,
For example, finely divided forms of titanium dioxide, zinc oxide, or UVA and UVB blockers, and other known skin lightening compounds. Preferred skin lightening agents are niacin and niacinamide. The composition may contain additional skin lightening agent in an amount of 0-10% by weight.
【００１９】 本発明組成物は更に、化粧品相溶性の防腐剤、増粘剤、香料、色素、並びに、
保湿剤、皮膚緩和薬及び加齢防止剤などの皮膚有効物質を含有し得る。[0019] The composition of the present invention further comprises a cosmetically compatible preservative, thickener, flavor, dye, and
It may contain skin-active substances such as humectants, emollients and aging inhibitors.
【００２０】 組成物は更に、好ましくは１０重量％以下、より好ましくは５重量％以下とい
う少量の別の化粧品用乳化剤を含有し得る。The composition may further contain small amounts of another cosmetic emulsifier, preferably up to 10% by weight, more preferably up to 5% by weight.
【００２１】 湿潤剤及び保湿剤の例は、ポリオール、グリセロール、セチルアルコール、パ
ラフィン油、ラノリンとその誘導体、脂肪酸エステルなどである。また、シリコ
ーン油、シクロメチコーン、ジメチコーン、ジメチコノールなどのシリコーン化
合物なども使用し得る。Examples of humectants and humectants are polyols, glycerol, cetyl alcohol, paraffin oil, lanolin and its derivatives, fatty acid esters and the like. Further, silicone compounds such as silicone oil, cyclomethicone, dimethicone, and dimethiconol may also be used.
【００２２】 異なる指示がない限り、本文及び特許請求の範囲に示したパーセンテージはい
ずれも組成物の重量％である。Unless otherwise indicated, all percentages given in the text and in the claims are by weight of the composition.
【００２３】 本発明を実施例によって以下に説明する。実施例は本発明の単なる代表例であ
り、本発明の範囲は実施例の記載に全く限定されない。The present invention will be described below by way of examples. The examples are merely representative examples of the present invention, and the scope of the present invention is not limited to the description of the examples.
【００２４】 実施例 Ａ．クリームの組成 本発明の化粧用クリームの実施例を表１に示す。[0024]Example A.Cream composition Table 1 shows examples of the cosmetic cream of the present invention.
【００２５】[0025]
【表１】 ＃５％乳酸塩＋２％ナトリウムステアロイルラクチレート＋１ナイアシンアミド
＠ナトリウムステアロイルラクチレート ＊８％乳酸塩[Table 1] # 5% lactate + 2% sodium stearoyl lactylate + 1 niacinamide ＠ sodium stearoyl lactylate * 8% lactate
【００２６】 表中の数値は組成物中の重量％を表す。The numerical values in the table represent% by weight in the composition.
【００２７】 Ｂ．皮膚美白効果 前腕の皮膚の色の均一性に基づいてパネリストを選抜し、２５人の志願者から
パネルを構成して各評価試験を行った。測定用量のクリーム（実施例１、２また
は３）を片方の前腕に１日２回塗布した。８週間の試験期間にわたって目視評価
を行った。皮膚美白のレベルを表２に示す。B.Skin whitening effect Panelists were selected based on the uniformity of skin color on the forearm, and from 25 volunteers
Each evaluation test was performed by constructing a panel. Measured dose of cream (Examples 1, 2 or
Was applied to one forearm twice a day. Visual assessment over an 8-week test period
Was done. Table 2 shows the skin lightening levels.
【００２８】[0028]
【表２】 [Table 2]
【００２９】 従って本発明によれば、可逆性を有しており且つ副作用を全く生じない皮膚美
白用組成物を提供することが可能である。組成物は昼夜を問わず活性である。Therefore, according to the present invention, it is possible to provide a skin whitening composition that has reversibility and does not cause any side effects. The composition is active day and night.
【手続補正書】特許協力条約第３４条補正の翻訳文提出書[Procedural Amendment] Submission of translation of Article 34 Amendment of the Patent Cooperation Treaty
【提出日】平成１２年１月２７日（２０００．１．２７）[Submission Date] January 27, 2000 (2000.1.27)
【手続補正１】[Procedure amendment 1]
【補正対象書類名】明細書[Document name to be amended] Statement
【補正対象項目名】特許請求の範囲[Correction target item name] Claims
【補正方法】変更[Correction method] Change
【補正内容】[Correction contents]
【特許請求の範囲】[Claims]
【手続補正２】[Procedure amendment 2]
【補正対象書類名】明細書[Document name to be amended] Statement
【補正対象項目名】０００９[Correction target item name] 0009
【補正方法】変更[Correction method] Change
【補正内容】[Correction contents]
【０００９】 従って本発明の目的は、皮膚美白効果を得るためにバニシングクリーム基剤に
よって乳酸及びその誘導体を皮膚に配給する化粧品組成物を提供することである
。[0009] Accordingly, it is an object of the present invention to provide a cosmetic composition for delivering lactic acid and its derivatives to the skin with a vanishing cream base to obtain a skin whitening effect.
【手続補正３】[Procedure amendment 3]
【補正対象書類名】明細書[Document name to be amended] Statement
【補正対象項目名】００１０[Correction target item name] 0010
【補正方法】変更[Correction method] Change
【補正内容】[Correction contents]
【００１０】 即ち本発明は、 （Ａ）５−２５重量％のＣ１２−Ｃ２０脂肪酸と、 （Ｂ）０．１−１０重量％の脂肪酸セッケンと、 （Ｃ）０．０５−１０重量％のα−ヒドロキシカルボン酸及び／またはα−アシ
ルオキシカルボン酸のアルカリ金属塩またはアルカリ土類金属塩と、 から成るヒトの皮膚に外用塗布するための皮膚美白用化粧品組成物に関する。That is, the present invention provides (A) 5 to 25% by weight of a C12-C20 fatty acid, (B) 0.1 to 10% by weight of a fatty acid soap, and (C) 0.05 to 10% by weight of α. An alkali metal salt or an alkaline earth metal salt of hydroxycarboxylic acid and / or α-acyloxycarboxylic acid, and a skin whitening cosmetic composition for external application to human skin.
【手続補正４】[Procedure amendment 4]
【補正対象書類名】明細書[Document name to be amended] Statement
【補正対象項目名】００１１[Correction target item name] 0011
【補正方法】変更[Correction method] Change
【補正内容】[Correction contents]
【００１１】 本発明組成物によって得られる皮膚美白効果は可逆性であり、副作用を全く生
じない。本発明組成物は日中も夜間も活性である。The skin lightening effect obtained by the composition according to the invention is reversible and does not cause any side effects. The compositions of the present invention are active during the day and at night.
【手続補正５】[Procedure amendment 5]
【補正対象書類名】明細書[Document name to be amended] Statement
【補正対象項目名】００１２[Correction target item name] 0012
【補正方法】変更[Correction method] Change
【補正内容】[Correction contents]
【００１２】 好ましくはアルカリ金属塩またはアルカリ土類金属塩が乳酸の塩及び／または
アシルオキシラクチレートの塩である。最も好ましくは塩がステアロイルラクチ
レートの塩である。Preferably, the alkali metal salt or alkaline earth metal salt is a salt of lactic acid and / or a salt of acyloxylactylate. Most preferably, the salt is a salt of stearoyl lactylate.
【手続補正６】[Procedure amendment 6]
【補正対象書類名】明細書[Document name to be amended] Statement
【補正対象項目名】００１３[Correction target item name] 0013
【補正方法】変更[Correction method] Change
【補正内容】[Correction contents]
【００１３】 本発明のより好ましい特徴によれば、化粧品組成物が少なくとも０．０５重量
％のステアロイルラクチレートのアルカリ金属塩を含む。According to a more preferred feature of the invention, the cosmetic composition comprises at least 0.05% by weight of an alkali metal salt of stearoyl lactylate.
【手続補正７】[Procedure amendment 7]
【補正対象書類名】明細書[Document name to be amended] Statement
【補正対象項目名】００１４[Correction target item name] 0014
【補正方法】変更[Correction method] Change
【補正内容】[Correction contents]
【００１４】 α−ヒドロキシカルボン酸及び／またはα−アシルオキシカルボン酸の特に好
適な塩はナトリウム塩である。Particularly preferred salts of α-hydroxycarboxylic acids and / or α-acyloxycarboxylic acids are the sodium salts.
【手続補正８】[Procedure amendment 8]
【補正対象書類名】明細書[Document name to be amended] Statement
【補正対象項目名】００１５[Correction target item name] 0015
【補正方法】変更[Correction method] Change
【補正内容】[Correction contents]
【００１５】 組成物は好ましくは１０−２０重量％のＣ１２−Ｃ２０脂肪酸を含む。[0015] The composition preferably comprises 10-20% by weight of C12-C20 fatty acids.
───────────────────────────────────────────────────── フロントページの続き (81)指定国 ＥＰ(ＡＴ，ＢＥ，ＣＨ，ＣＹ， ＤＥ，ＤＫ，ＥＳ，ＦＩ，ＦＲ，ＧＢ，ＧＲ，ＩＥ，Ｉ Ｔ，ＬＵ，ＭＣ，ＮＬ，ＰＴ，ＳＥ)，ＯＡ(ＢＦ，ＢＪ ，ＣＦ，ＣＧ，ＣＩ，ＣＭ，ＧＡ，ＧＮ，ＧＷ，ＭＬ， ＭＲ，ＮＥ，ＳＮ，ＴＤ，ＴＧ)，ＡＰ(ＧＨ，ＧＭ，Ｋ Ｅ，ＬＳ，ＭＷ，ＳＤ，ＳＺ，ＵＧ，ＺＷ)，ＥＡ(ＡＭ ，ＡＺ，ＢＹ，ＫＧ，ＫＺ，ＭＤ，ＲＵ，ＴＪ，ＴＭ) ，ＡＬ，ＡＭ，ＡＴ，ＡＵ，ＡＺ，ＢＡ，ＢＢ，ＢＧ， ＢＲ，ＢＹ，ＣＡ，ＣＨ，ＣＮ，ＣＵ，ＣＺ，ＤＥ，Ｄ Ｋ，ＥＥ，ＥＳ，ＦＩ，ＧＢ，ＧＤ，ＧＥ，ＧＨ，ＧＭ ，ＨＲ，ＨＵ，ＩＤ，ＩＬ，ＩＮ，ＩＳ，ＪＰ，ＫＥ， ＫＧ，ＫＰ，ＫＲ，ＫＺ，ＬＣ，ＬＫ，ＬＲ，ＬＳ，Ｌ Ｔ，ＬＵ，ＬＶ，ＭＤ，ＭＧ，ＭＫ，ＭＮ，ＭＷ，ＭＸ ，ＮＯ，ＮＺ，ＰＬ，ＰＴ，ＲＯ，ＲＵ，ＳＤ，ＳＥ， ＳＧ，ＳＩ，ＳＫ，ＳＬ，ＴＪ，ＴＭ，ＴＲ，ＴＴ，Ｕ Ａ，ＵＧ，ＵＺ，ＶＮ，ＹＵ，ＺＷ (72)発明者 ラーマン，ゴビンダラヤン インド国、ムンバイ・400 099、アンデ リ・イースト、チヤカラ、ヒンズースタ ン・リーバ・リミテツド、リサーチ・セン ター気付（番地なし) (72)発明者 ソナ，プシユカー インド国、ムンバイ・400 099、アンデ リ・イースト、チヤカラ、ヒンズースタ ン・リーバ・リミテツド、リサーチ・セン ター気付（番地なし) (72)発明者 スリアナラヤナン，ラメシユ インド国、ムンバイ・400 099、アンデリ （イースト）、チヤカラ、ヒンズースタ ン・リーバ・リミテツド、リサーチ・セン ター気付（番地なし) (72)発明者 ワーグ，スシヤマ・シユリパツド インド国、バンガロー・560 066、ホワイ トフイールド・ピー・オー、メイン・ロー ド・64、ヒンズースタン・リーバ・リミテ ツド、リサーチ・センター気付（番地な し) Ｆターム(参考） 4C083 AC072 AC241 AC242 AC301 AC302 AC482 CC02 DD22 DD31 EE10 EE16 ──────────────────────────────────────────────────続 き Continuation of front page (81) Designated country EP (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE ), OA (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG), AP (GH, GM, KE, LS, MW, SD, SZ, UG, ZW), EA (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM), AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE , KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW (72) Inventor Rahman, Govindarayan India, Mumbai 400 099, Andheri East (72) Inventor Sona, Pushukar India, Mumbai 400 099, Andheri East, Chiyakala, Hindustan Liva Limited (72) Inventor Surianarayanan, Rameshyu India, Mumbai 400 099, Andheri (east), Chiyakala, Hindustan (72) Inventor, Vag, Sushiyama Syuripadd India, Bungalow 560 066, Whitefield P.O., Main Road 64, Hindu Stan Lever・ Limited, Research Center notice (no address) F-term (reference) 4C083 AC072 AC241 AC242 AC301 AC302 AC482 CC02 DD22 DD31 EE10 EE16
Claims (8)
ルオキシカルボン酸のアルカリ金属塩またはアルカリ土類金属塩と、 から成るヒトの皮膚に外用塗布するための皮膚美白用化粧品組成物。(A) 5 to 25% by weight of a C12-C20 fatty acid; (B) 0.1 to 10% by weight of a fatty acid soap; and (C) 0.05 to 10% by weight of an α-hydroxycarboxylic acid. An alkali metal salt or an alkaline earth metal salt of an acid and / or an α-acyloxycarboxylic acid, and a skin whitening cosmetic composition for external application to human skin.
またはアシルオキシラクチレートの塩であることを特徴とする請求項１または２
に記載の組成物。2. The method according to claim 1, wherein the alkali metal salt or alkaline earth metal salt is lactic acid salt and / or
Or a salt of an acyloxy lactylate.
A composition according to claim 1.
ことを特徴とする請求項３に記載の組成物。3. The composition according to claim 3, wherein the acyloxy lactylate is steroyl lactylate.
ルボン酸のナトリウム塩を含むことを特徴とする請求項１から３のいずれか一項
に記載の組成物。4. The composition according to claim 1, which comprises a sodium salt of α-hydroxycarboxylic acid and / or α-acyloxycarboxylic acid.
とする請求項１から４のいずれか一項に記載の組成物。5. The composition according to claim 1, comprising 10-20% by weight of C12-C20 fatty acids.
項１から５のいずれか一項に記載の組成物。6. The composition according to claim 1, comprising 1 to 5% by weight of a fatty acid soap.
いずれか一項に記載の組成物。7. The composition according to claim 1, comprising an additional skin lightening agent.
塗布する皮膚美白用化粧方法。8. A skin whitening cosmetic method comprising externally applying the composition according to any one of claims 1 to 7 to skin.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9801597.7 | 1998-01-26 | ||
| GBGB9801597.7A GB9801597D0 (en) | 1998-01-26 | 1998-01-26 | Skin lightening composition |
| PCT/EP1998/008147 WO1999037280A1 (en) | 1998-01-26 | 1998-12-08 | Skin lightening composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002501013A true JP2002501013A (en) | 2002-01-15 |
| JP2002501013A5 JP2002501013A5 (en) | 2009-04-09 |
Family
ID=10825885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000528264A Pending JP2002501013A (en) | 1998-01-26 | 1998-12-08 | Skin whitening composition |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JP2002501013A (en) |
| CN (1) | CN1161098C (en) |
| AU (1) | AU2161299A (en) |
| GB (1) | GB9801597D0 (en) |
| ID (1) | ID28137A (en) |
| WO (1) | WO1999037280A1 (en) |
| ZA (1) | ZA9811444B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1121926A1 (en) * | 2000-02-07 | 2001-08-08 | Laboratoires Serobiologiques(Societe Anonyme) | Cosmetic preparations containing Waltheria indica extracts |
| GB0006865D0 (en) * | 2000-03-21 | 2000-05-10 | Unilever Plc | Low pH high fatty acid vanishing cream |
| MXPA02010680A (en) * | 2000-05-03 | 2003-03-10 | Unilever Nv | Detergent bar composition with benefit agents. |
| US20130266528A1 (en) * | 2010-10-04 | 2013-10-10 | Punam Bandyopadhyay | Skin lightening composition |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2593714B2 (en) * | 1989-09-20 | 1997-03-26 | 株式会社 林原生物化学研究所 | Whitening agent |
| EP0793481B1 (en) * | 1993-08-13 | 2004-06-02 | Unilever Plc | Cosmetic composition containing hydroxy alkanoate derivatives |
| US5766575A (en) * | 1996-06-14 | 1998-06-16 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Method and composition for skin lightening |
| WO1998027193A1 (en) * | 1996-12-16 | 1998-06-25 | The Procter & Gamble Company | Personal cleansing bar composition containing sodium lauroyl lactylate |
-
1998
- 1998-01-26 GB GBGB9801597.7A patent/GB9801597D0/en not_active Ceased
- 1998-12-08 AU AU21612/99A patent/AU2161299A/en not_active Abandoned
- 1998-12-08 ID IDW20001422A patent/ID28137A/en unknown
- 1998-12-08 WO PCT/EP1998/008147 patent/WO1999037280A1/en active Application Filing
- 1998-12-08 CN CNB988133199A patent/CN1161098C/en not_active Expired - Fee Related
- 1998-12-08 JP JP2000528264A patent/JP2002501013A/en active Pending
- 1998-12-14 ZA ZA9811444A patent/ZA9811444B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1283988A (en) | 2001-02-14 |
| GB9801597D0 (en) | 1998-03-25 |
| ZA9811444B (en) | 2000-06-14 |
| AU2161299A (en) | 1999-08-09 |
| CN1161098C (en) | 2004-08-11 |
| ID28137A (en) | 2001-05-03 |
| WO1999037280A1 (en) | 1999-07-29 |
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