JP2002370974A - Sustained release antiallergic agent, sustained release antiallergic preparation and daily sanitary good using the antiallergic agent - Google Patents
Sustained release antiallergic agent, sustained release antiallergic preparation and daily sanitary good using the antiallergic agentInfo
- Publication number
- JP2002370974A JP2002370974A JP2001184373A JP2001184373A JP2002370974A JP 2002370974 A JP2002370974 A JP 2002370974A JP 2001184373 A JP2001184373 A JP 2001184373A JP 2001184373 A JP2001184373 A JP 2001184373A JP 2002370974 A JP2002370974 A JP 2002370974A
- Authority
- JP
- Japan
- Prior art keywords
- oil
- antiallergic
- sustained
- release
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Gloves (AREA)
- Housing For Livestock And Birds (AREA)
- Undergarments, Swaddling Clothes, Handkerchiefs Or Underwear Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Respiratory Apparatuses And Protective Means (AREA)
- Sanitary Thin Papers (AREA)
- Bedding Items (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Professional, Industrial, Or Sporting Protective Garments (AREA)
- Mattresses And Other Support Structures For Chairs And Beds (AREA)
- Absorbent Articles And Supports Therefor (AREA)
- Body Washing Hand Wipes And Brushes (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、鼻詰まり、くしゃ
みなどのアレルギー症状の緩和、解消効果のある徐放性
抗アレルギー剤、徐放性抗アレルギー製剤及び該抗アレ
ルギー剤を用いた日常衛生用品に関するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a sustained-release anti-allergic agent, a sustained-release anti-allergic preparation, and a daily hygiene product using the anti-allergic agent, which are effective in alleviating and eliminating allergic symptoms such as nasal congestion and sneezing. It is about.
【０００２】[0002]
【従来の技術】近年、アレルギー性疾患は増加の一途を
たどっている。特にアレルギー性鼻炎、花粉症、アレル
ギー性皮膚炎など、即時型アレルギーが大きく係わる疾
患に罹患する人が増えている。2. Description of the Related Art In recent years, allergic diseases have been increasing. In particular, an increasing number of people are afflicted with diseases that are greatly related to immediate allergy, such as allergic rhinitis, hay fever and allergic dermatitis.
【０００３】このようなアレルギー性鼻炎により鼻が詰
まった場合などに、メントールで鼻通りを良くすること
により、鼻詰まりの不快感などの解消を図った衛生マス
クが提案されている（登録実用新案第３０５７６７９号
公報、特開平８−８９５９１号公報など）。[0003] In the case where the nose is blocked due to such allergic rhinitis or the like, a sanitary mask has been proposed which aims to eliminate the discomfort of the blocked nose by improving the nasal passage with menthol (registered utility model). No. 3057679, JP-A-8-89591, etc.).
【０００４】しかしながら、メントールを単独で用いた
場合、メントールの昇華速度が速いため、メントールの
刺激臭が強すぎたり、また、鼻詰まり感、くしゃみ等の
アレルギー症状の緩和効果の持続性がなく、十分満足で
きるものが提供されていないのが現状である。However, when menthol is used alone, the sublimation rate of menthol is high, so that the irritating odor of menthol is too strong, and the effect of alleviating allergic symptoms such as nasal congestion and sneezing is not maintained. At present, it is not possible to provide anything satisfactory.
【０００５】一方、居室、トイレット、車内等の空間に
配置する種々の日常衛生用品に自然な芳香を付与して快
適な生活が送れるようにすることが望まれている。[0005] On the other hand, it is desired that various daily sanitary articles arranged in a space such as a living room, a toilet, and a car be given a natural fragrance so that a comfortable life can be enjoyed.
【０００６】[0006]
【発明が解決しようとする課題】本発明は、このような
状況下、従来における諸問題を解決し、以下の目的を達
成することを課題とする。即ち、本発明は、鼻詰まり、
くしゃみなどのアレルギー症状の緩和、解消に効果的な
徐放性抗アレルギー剤、徐放性抗アレルギー製剤及び該
抗アレルギー剤を用いた日常衛生用品を提供することを
目的とする。The object of the present invention is to solve the conventional problems in such a situation and to achieve the following objects. That is, the present invention provides a nasal congestion,
An object of the present invention is to provide a sustained-release anti-allergic agent, a sustained-release anti-allergic preparation, and a daily hygiene article using the anti-allergic agent, which are effective in alleviating and eliminating allergic symptoms such as sneezing.
【０００７】[0007]
【課題を解決するための手段】本発明者は、前記課題を
解決すべく鋭意検討を重ねた結果、植物性精油とｄｌ−
メントールを有効成分とする徐放性抗アレルギー剤、特
にオリーブ油と桂皮油とｄｌ−メントールを有効成分と
して含有する徐放性抗アレルギー剤が、メントールの刺
激臭をまろやかにすることができると共に、鼻詰まり
感、くしゃみ等のアレルギー症状を効果的に緩和、改善
できることを知見した。Means for Solving the Problems The present inventors have made intensive studies to solve the above-mentioned problems, and as a result, have found that vegetable essential oil and dl-
A sustained-release antiallergic agent containing menthol as an active ingredient, particularly a sustained-release antiallergic agent containing olive oil, cinnamon oil and dl-menthol as active ingredients, can make the irritating odor of menthol mild, It has been found that allergic symptoms such as clogging and sneezing can be effectively alleviated and improved.
【０００８】また、前記徐放性抗アレルギー剤を粒状
化、又は基体に含浸させた徐放性抗アレルギー製剤、若
しくは前記徐放性抗アレルギー剤を混練材と混練し、得
られた混練物を造粒、又は基体に担持させた徐放性抗ア
レルギー製剤が、メントールの刺激臭をよりまろやかに
することができると共に、持続性や取扱い性が向上し、
マスク、鼻テープ、ガーゼ、包帯、タオル、ハンカチ、
おしぼり、ティッシュ、ウエットティッシュ、オムツ、
手袋、下着、白衣、手術着、パジャマ、ネグリジェ、ス
エットスーツ、シーツ、ベッドカバー、ベッドパッド、
ベッド、布団、毛布、タオルケット、ソファー、枕及び
枕カバーから選ばれる日常衛生用品に優れた抗アレルギ
ー性を付与することができることを知見し、本発明をな
すに至った。[0008] Further, the above-mentioned sustained-release anti-allergic agent is granulated or impregnated into a substrate, or a sustained-release anti-allergic preparation is kneaded with a kneading material. Granulated or sustained-release anti-allergic preparations carried on a substrate can make the irritating odor of menthol more mild, and improve the durability and handleability,
Mask, nose tape, gauze, bandage, towel, handkerchief,
Towel, tissue, wet tissue, diaper,
Gloves, underwear, lab coat, surgical gown, pajamas, negligee, sweat suit, sheets, bedspread, bed pad,
The inventors have found that excellent antiallergic properties can be imparted to daily hygiene articles selected from beds, futons, blankets, towel blankets, sofas, pillows and pillow covers, and have accomplished the present invention.
【０００９】即ち、本発明は、下記の徐放性抗アレルギ
ー剤、徐放性抗アレルギー製剤及び該抗アレルギー剤を
用いた日常衛生用品を提供する。That is, the present invention provides the following sustained release antiallergic agent, sustained release antiallergic preparation, and daily hygiene articles using the antiallergic agent.
【００１０】請求項１の発明は、植物性精油とｄｌ−メ
ントールを有効成分として含有することを特徴とする徐
放性抗アレルギー剤である。[0010] The invention of claim 1 is a sustained-release antiallergic agent characterized by containing a vegetable essential oil and dl-menthol as active ingredients.
【００１１】請求項２の発明は、植物性精油が、オリー
ブ油、桂皮油、ホホバ油、ひまし油、ツバキ油、月見草
油、サフラワー油、ベニバナ油、落花生油、スクワラ
ン、ベルガモット油、アボガド油、ひまわり油、ユーカ
リ油、テレピン油、カカオ油、ローズ油、トウモロコシ
油、ナタネ油、綿実油、椰子油及びケシ油から選ばれる
１種又は２種以上である請求項１記載の徐放性抗アレル
ギー剤である。The invention of claim 2 is characterized in that the vegetable essential oils are olive oil, cinnamon oil, jojoba oil, castor oil, camellia oil, evening primrose oil, safflower oil, safflower oil, peanut oil, squalane, bergamot oil, avocado oil, sunflower The sustained-release antiallergic agent according to claim 1, which is one or more kinds selected from oil, eucalyptus oil, turpentine oil, cocoa oil, rose oil, corn oil, rapeseed oil, cottonseed oil, coconut oil and poppy oil. is there.
【００１２】請求項３の発明は、オリーブ油と桂皮油と
ｄｌ−メントールを有効成分として含有する請求項１又
は２記載の徐放性抗アレルギー剤である。The invention according to claim 3 is the sustained-release antiallergic agent according to claim 1 or 2, which contains olive oil, cinnamon oil and dl-menthol as active ingredients.
【００１３】請求項４の発明は、オリーブ油と桂皮油と
ｄｌ−メントールを、質量比でオリーブ油：桂皮油：ｄ
ｌ−メントール＝１〜１０：１〜１０：１〜１０の割合
で含む請求項３記載の徐放性抗アレルギー剤である。According to a fourth aspect of the present invention, olive oil, cinnamon oil and dl-menthol are mixed in a mass ratio of olive oil: cinnamon oil: d.
4. The sustained-release antiallergic agent according to claim 3, wherein l-menthol is contained at a ratio of 1 to 10: 1 to 10: 1 to 10.
【００１４】請求項５の発明は、請求項１乃至４のいず
れか１項記載の徐放性抗アレルギー剤を粒状化、又は基
体に含浸させたことを特徴とする徐放性抗アレルギー製
剤である。[0014] The invention of claim 5 is a sustained-release anti-allergic preparation characterized in that the sustained-release anti-allergic agent according to any one of claims 1 to 4 is granulated or impregnated in a substrate. is there.
【００１５】請求項６の発明は、請求項１乃至４のいず
れか１項記載の徐放性抗アレルギー剤を混練材と混練
し、得られた混練物を造粒、又は基体に担持させたこと
を特徴とする徐放性抗アレルギー製剤である。According to a sixth aspect of the present invention, the sustained-release antiallergic agent according to any one of the first to fourth aspects is kneaded with a kneading material, and the obtained kneaded product is granulated or supported on a substrate. It is a sustained-release antiallergic preparation characterized by the following.
【００１６】請求項７の発明は、請求項１乃至４のいず
れか１項記載の徐放性抗アレルギー剤の合計有効成分量
と混練材との混合割合が、質量比で合計有効成分量：混
練材＝１：０．１〜１０．０である請求項６記載の徐放
性抗アレルギー製剤である。According to a seventh aspect of the present invention, the total amount of the active ingredient of the sustained-release antiallergic agent according to any one of the first to fourth aspects and the mixing ratio of the kneading material are determined by mass ratio of the total amount of the active ingredient: The sustained-release antiallergic preparation according to claim 6, wherein the kneading material is 1: 0.1 to 10.0.
【００１７】請求項８の発明は、基体が多孔質体である
請求項５乃至７のいずれか１項記載の徐放性抗アレルギ
ー製剤である。The invention of claim 8 is the sustained-release antiallergic preparation according to any one of claims 5 to 7, wherein the substrate is a porous body.
【００１８】請求項９の発明は、請求項１乃至４のいず
れか１項記載の徐放性抗アレルギー剤、又は請求項５乃
至８のいずれか１項記載の徐放性抗アレルギー製剤を一
部又は全部に備えたことを特徴とする日常衛生用品であ
る。According to a ninth aspect of the present invention, there is provided the sustained release antiallergic agent according to any one of the first to fourth aspects, or the sustained release antiallergic preparation according to any one of the fifth to eighth aspects. It is a daily hygiene article provided in part or all.
【００１９】請求項１０の発明は、請求項５乃至８のい
ずれか１項記載の徐放性抗アレルギー製剤を封入したパ
ッケージを取付けたことを特徴とする日常衛生用品であ
る。A tenth aspect of the present invention is a daily hygiene article provided with a package containing the sustained-release antiallergic preparation according to any one of the fifth to eighth aspects.
【００２０】請求項１１の発明は、日常衛生用品が、マ
スク、鼻テープ、ガーゼ、包帯、タオル、ハンカチ、お
しぼり、ティッシュ、ウエットティッシュ、オムツ、手
袋、下着、白衣、手術着、パジャマ、ネグリジェ、スエ
ットスーツ、シーツ、ベッドカバー、ベッドパッド、ベ
ッド、布団、毛布、タオルケット、ソファー、枕及び枕
カバーから選ばれる請求項９又は１０記載の日常衛生用
品である。[0020] The invention of claim 11 is the daily hygiene article, wherein the mask, nose tape, gauze, bandage, towel, handkerchief, towel, tissue, wet tissue, diaper, gloves, underwear, lab coat, surgical gown, pajamas, negligee, The daily hygiene article according to claim 9 or 10, selected from a sweat suit, a sheet, a bed cover, a bed pad, a bed, a futon, a blanket, a towel blanket, a sofa, a pillow and a pillow cover.
【００２１】[0021]
【発明の実施の形態】以下、本発明について、更に詳し
く説明する。<徐放性抗アレルギー剤>本発明の徐放性抗
アレルギー剤は、植物性精油とｄｌ−メントールとを有
効成分として含有する。BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in more detail. <Sustained Release Antiallergic Agent> The sustained release antiallergic agent of the present invention contains vegetable essential oil and dl-menthol as active ingredients.
【００２２】前記ｄｌ−メントールとしては、特に制限
されず、ｄｌ−メントール以外にも、ｄｌ−メントール
を含むハッカ油、カンフル、ペパーミントなどを適宜用
いることができる。The dl-menthol is not particularly limited, and besides dl-menthol, mint oil containing dl-menthol, camphor, peppermint and the like can be used as appropriate.
【００２３】前記植物性精油としては、例えば、オリー
ブ油、桂皮油、ホホバ油、ひまし油、ツバキ油、月見草
油、サフラワー油、ベニバナ油、落花生油、スクワラ
ン、ベルガモット油、アボガド油、ひまわり油、ユーカ
リ油、テレピン油、カカオ油、ローズ油、トウモロコシ
油、ナタネ油、綿実油、椰子油及びケシ油などが挙げら
れ、これらの１種を単独で又は２種以上を組み合わせて
用いることができる。これらの中でも、オリーブ油、桂
皮油などが好ましい。The essential vegetable oils include, for example, olive oil, cinnamon oil, jojoba oil, castor oil, camellia oil, evening primrose oil, safflower oil, safflower oil, peanut oil, squalane, bergamot oil, avocado oil, sunflower oil, eucalyptus oil Examples thereof include oil, turpentine oil, cocoa oil, rose oil, corn oil, rapeseed oil, cottonseed oil, coconut oil, and poppy oil. One of these can be used alone, or two or more can be used in combination. Among these, olive oil and cinnamon oil are preferred.
【００２４】本発明の徐放性抗アレルギー剤は、植物性
精油とｄｌ−メントールを、質量比で植物性精油：ｄｌ
−メントール＝１〜９：９〜１の割合で含むことが好ま
しく、より好ましくは植物性精油：ｄｌ−メントール＝
３〜７：７〜３である。The sustained-release antiallergic agent of the present invention comprises a vegetable essential oil and dl-menthol in a mass ratio of vegetable essential oil: dl.
-Menthol = 1 to 9: preferably contained in a ratio of 9 to 1, more preferably vegetable essential oil: dl-menthol =
3-7: 7-3.
【００２５】また、本発明の徐放性抗アレルギー剤は、
オリーブ油と桂皮油とｄｌ−メントールを有効成分とし
て含有することが好ましい。このように、上述した植物
精油の中からオリーブ油と桂皮油とを選択することによ
り、ｄｌ−メントールの刺激臭がまろやかになると共
に、持続性が向上し、鼻詰まり感、くしゃみが解消し得
るものである。Further, the sustained-release antiallergic agent of the present invention comprises
It is preferable to contain olive oil, cinnamon oil and dl-menthol as active ingredients. As described above, by selecting olive oil and cinnamon oil from the above-mentioned vegetable essential oils, the irritating odor of dl-menthol is rounded, the sustainability is improved, and nasal congestion and sneezing can be eliminated. It is.
【００２６】この場合、オリーブ油と桂皮油とｄｌ−メ
ントールを質量比でオリーブ油：桂皮油：ｄｌ−メント
ール＝１〜１０：１〜１０：１〜１０の割合で含むこと
が好ましく、より好ましくはオリーブ油：桂皮油：ｄｌ
−メントール＝２〜８：２〜８：２〜８である。前記オ
リーブ油と桂皮油とｄｌ−メントールの混合割合範囲を
外れると、抗アレルギー作用が十分発揮されなかった
り、また、メントールの刺激臭が強すぎたり、持続性が
不十分となって、実用性が低下する場合がある。In this case, it is preferred that the olive oil, cinnamon oil and dl-menthol are contained in a mass ratio of olive oil: cinnamon oil: dl-menthol = 1-10: 1-10: 1-10, more preferably olive oil. : Cinnamon oil: dl
-Menthol = 2-8: 2-8: 2-8. If the mixing ratio of the olive oil, cinnamon oil and dl-menthol is out of the range, the antiallergic effect may not be sufficiently exhibited, or the irritating odor of menthol may be too strong or the persistence may be insufficient. May decrease.
【００２７】なお、本発明の徐放性抗アレルギー剤に
は、上記以外の任意成分として、通常用いられる各種配
合剤、例えばアルコール類、界面活性剤、保湿剤、増粘
剤、賦形剤、防腐剤、酸化防止剤、キレート剤、ｐＨ調
整剤、香料、色素、紫外線吸収剤、紫外線散乱剤、ビタ
ミン類、アミノ酸類などを配合することができる。な
お、任意成分はこれらに限定されるものではない。The sustained-release antiallergic agent of the present invention may contain, as optional components other than those described above, various commonly used compounding agents such as alcohols, surfactants, humectants, thickeners, excipients, Preservatives, antioxidants, chelating agents, pH adjusters, fragrances, pigments, ultraviolet absorbers, ultraviolet scattering agents, vitamins, amino acids, and the like can be added. The optional components are not limited to these.
【００２８】<徐放性抗アレルギー製剤>本発明の徐放性
抗アレルギー製剤は、植物性精油（特にオリーブ油と桂
皮油）とｄｌ−メントールを有効成分として含有する前
記徐放性抗アレルギー剤を粒状化、又は基体に含浸させ
たものであり、これにより、優れた抗アレルギー効果に
加えて、取扱性が大幅に向上するものである。<Sustained-release antiallergic preparation> The sustained-release antiallergic preparation of the present invention comprises the above-mentioned sustained-release antiallergic agent containing vegetable essential oils (particularly olive oil and cinnamon oil) and dl-menthol as active ingredients. It is granulated or impregnated in a substrate, which greatly improves handling properties in addition to excellent antiallergic effects.
【００２９】この場合、粒状化の方法としては特に制限
されず公知の造粒方法を採用することができる。例え
ば、噴霧流動造粒法、遠心流動造粒法などにより所望の
平均粒径のものを形成することができる。なお、基体に
ついては後述する。In this case, the granulation method is not particularly limited, and a known granulation method can be employed. For example, those having a desired average particle size can be formed by spray fluidized granulation, centrifugal fluidized granulation, or the like. The base will be described later.
【００３０】また、本発明の徐放性抗アレルギー製剤
は、植物性精油（特にオリーブ油と桂皮油）とｄｌ−メ
ントールを有効成分として含有する前記徐放性抗アレル
ギー剤を混練材と混練し、得られた混練物を造粒、又は
基体に担持させたものであり、これにより、優れた抗ア
レルギー効果に加えて、徐放性抗アレルギー剤の飽和蒸
気圧を抑制し得、より優れた徐放性能を得ることができ
ると共に、常温で固形状にすることが可能となり、取扱
い性が大幅に向上するものである。このことは、徐放性
抗アレルギー剤が使用開始までの保管中にバリア包装材
で包装されることを想定した場合、包装材内部で発生す
る植物性精油の結露やｄｌ−メントールの結晶析出防止
が可能となる点で有利である。Further, the sustained-release antiallergic preparation of the present invention is obtained by kneading the above-mentioned sustained-release antiallergic agent containing vegetable essential oils (particularly olive oil and cinnamon oil) and dl-menthol as active ingredients with a kneading material, The obtained kneaded material is granulated or supported on a substrate, whereby, in addition to the excellent antiallergic effect, the saturated vapor pressure of the sustained-release antiallergic agent can be suppressed, and more excellent Release performance can be obtained, and it can be made into a solid state at normal temperature, so that handleability is greatly improved. This means that when the sustained-release antiallergic agent is wrapped in a barrier wrapping material during storage until the start of use, it prevents condensation of vegetable essential oil generated inside the wrapping material and crystallization of dl-menthol. This is advantageous in that it becomes possible.
【００３１】前記基体としては、特に制限されず、目的
に応じて適宜選定することができるが、担持量を多くで
きることから多孔質体が好ましい。また、基体の形態
は、特に制限されないが、取扱い性の面からシート状や
粒状が好ましい。The substrate is not particularly limited and can be appropriately selected according to the purpose. However, a porous body is preferable because the amount of the substrate can be increased. The form of the substrate is not particularly limited, but is preferably sheet-like or granular from the viewpoint of handleability.
【００３２】このような多孔質体としては、紙、不織
布、パルプシート、パルプマット、セルローススポン
ジ、セルロース粒子等のセルロース多孔質体；ポリビニ
ルアルコール、ポリ乳酸等の高分子多孔質体；ケイ酸
塩、シリカゲル、ゼオライト、アルミナ等の無機多孔質
体などが挙げられる。Examples of such a porous body include a cellulose porous body such as paper, nonwoven fabric, pulp sheet, pulp mat, cellulose sponge, and cellulose particles; a polymeric porous body such as polyvinyl alcohol and polylactic acid; , Silica gel, zeolite, and inorganic porous materials such as alumina.
【００３３】前記混練材としては、特に制限されず、目
的に応じて適宜選定することができるが、例えば、パラ
フィンワックス、マイクロクリスタリンワックス等の石
油ワックス；脂肪酸、カルナバワックス、ライスワック
ス等の天然ワックス；ロジン、ロジンエステル等の天然
樹脂；天然ゴム、合成ゴム等のゴム；ポリエステル、ア
クリル系樹脂等の合成高分子などが挙げられ、これらの
１種を単独で又は２種以上を組み合わせて用いることが
できる。The kneading material is not particularly limited and may be appropriately selected depending on the purpose. Examples thereof include petroleum wax such as paraffin wax and microcrystalline wax; and natural wax such as fatty acid, carnauba wax and rice wax. Natural resins such as rosin and rosin esters; rubbers such as natural rubber and synthetic rubber; synthetic polymers such as polyester and acrylic resin; and the like. One of these alone or a combination of two or more thereof is used. Can be.
【００３４】これらの混練材の中でも、融点が低いため
に加工性が良好であり、しかもそれ自体臭いが少ない石
油ワックス、天然ワックスなどが好適である。Among these kneading materials, petroleum wax, natural wax and the like, which have good workability due to their low melting point and which themselves have little odor, are preferred.
【００３５】なお、本発明の徐放性抗アレルギー製剤に
は、前記徐放性抗アレルギー剤と同様の任意成分を配合
することができる。なお、前記同様任意成分はこれらに
限定されるものではない。The sustained-release antiallergic preparation of the present invention may contain the same optional components as those of the sustained-release antiallergic agent. Note that, as described above, the optional components are not limited to these.
【００３６】本発明の徐放性抗アレルギー製剤は、例え
ば、植物性精油とｄｌ−メントールと混練材をミキサ
ー、ニーダー等の任意の方法で加熱しながら混練し、得
られた溶融混練物を所定の大きさの球状、粒状、ペレッ
ト状に成型したり、多孔質体などの基体に担持させるこ
とにより製造される。The sustained-release antiallergic preparation of the present invention is obtained, for example, by kneading vegetable essential oil, dl-menthol, and a kneading material while heating with a mixer, a kneader, or any other method. It is manufactured by molding into a spherical, granular, or pellet shape having a size of, or by supporting it on a substrate such as a porous body.
【００３７】前記植物性精油とｄｌ−メントールと混練
材の混練割合は、特に制限されないが、例えば、植物性
精油とｄｌ−メントールとの合計有効成分量と混練材と
の混練割合が、質量比で合計有効成分量：混練材＝１：
０．１〜１０．０であることが好ましい。The kneading ratio of the vegetable essential oil, dl-menthol and the kneading agent is not particularly limited. For example, the mass ratio of the total active ingredient amount of the vegetable essential oil and dl-menthol to the kneading agent is the mass ratio. And the total amount of active ingredients: kneading material = 1:
It is preferably 0.1 to 10.0.
【００３８】本発明の徐放性抗アレルギー製剤は、前記
徐放性抗アレルギー剤を基体に含浸させて製造する場
合、質量比で徐放性抗アレルギー剤：基体＝１：０．１
〜５０．０であることが好ましい。また、前記徐放性抗
アレルギー剤を混練材と混練し、得られた混練物を基体
に担持させた徐放性抗アレルギー製剤の場合は、質量比
で混練物：基体＝１：０．１〜１００．０であることが
好ましい。When the sustained release antiallergic preparation of the present invention is produced by impregnating the substrate with the sustained release antiallergic agent, the sustained release antiallergic agent: substrate = 1: 0.1 by mass ratio.
５50.0 is preferred. Further, in the case of a sustained-release antiallergic preparation in which the above-mentioned sustained-release antiallergic agent is kneaded with a kneading material and the obtained kneaded product is supported on a substrate, the kneaded product: substrate = 1: 0.1 by mass ratio. It is preferably from 10 to 100.0.
【００３９】<日常衛生用品>本発明の徐放性抗アレルギ
ー剤、又は徐放性抗アレルギー製剤を、包帯、マスク、
鼻バンド、ガーゼ、タオル、ハンカチ、おしぼり、ティ
ッシュ、ウエットティッシュ、オムツ、手袋、下着、白
衣、手術着等の医療衛生用品、又はパジャマ、ネグリジ
ェ、スエットスーツ、シーツ、ベッドカバー、ベッドパ
ッド、ベッド、布団、毛布、タオルケット、ソファー、
枕、枕カバー等の寝装用品の一部又は全体に備えること
により、これら日常衛生用品に抗アレルギー作用を付与
することができ、鼻詰まり感、くしゃみ等のアレルギー
症状の緩和、改善に寄与し得るものである。<Daily hygiene article> The sustained-release antiallergic agent or the sustained-release antiallergic preparation of the present invention is applied to a bandage, a mask,
Nose band, gauze, towel, handkerchief, towel, tissue, wet tissue, diaper, gloves, underwear, lab coat, surgical wear, and other medical hygiene products, or pajamas, negligees, sweat suits, sheets, bed covers, bed pads, beds, Futon, blanket, towel blanket, sofa,
By providing a part or the whole of bedding products such as pillows and pillow covers, these daily hygiene products can be given an anti-allergic effect, contributing to alleviation and improvement of allergic symptoms such as nasal congestion and sneezing. What you get.
【００４０】前記抗アレルギー剤を備える方法として
は、特に制限されず、徐放性抗アレルギー剤を配合した
スプレーを日常衛生用品に噴霧含浸する方法、徐放性抗
アレルギー製剤を直接取り付ける方法、更には徐放性抗
アレルギー製剤を通気性袋体等のパッケージに封入して
取り付ける方法などが挙げられる。The method of providing the antiallergic agent is not particularly limited, and includes a method of spray impregnating a daily hygiene article with a spray containing a sustained release antiallergic agent, a method of directly attaching a sustained release antiallergic preparation, For example, there is a method in which a sustained-release antiallergic preparation is sealed in a package such as a breathable bag and attached.
【００４１】前記通気性袋体としては、特に制限されな
いが、例えば、スパンボンド不織布、ニードルパンチ不
織布などの不織布、織布、フィルム、シートなどを縫
製、接着などにより袋体に加工することにより、所望の
形状を有する袋体を製造することができる。The air-permeable bag is not particularly limited. For example, a non-woven fabric such as a spun-bonded non-woven fabric and a needle-punched non-woven fabric, a woven fabric, a film, a sheet, or the like is processed into a bag by sewing or bonding. A bag having a desired shape can be manufactured.
【００４２】本発明の徐放性抗アレルギー製剤の使用方
法としては、具体的には、図１に示したように、本発明
の粒状である抗アレルギー製剤１を通気性のパッケージ
に封入し、このパッケージをマスク２のポケットに入れ
て取り付けることにより、メントールの爽快感により、
鼻通りがスムーズになり、花粉の季節などに好適なもの
である。As a method of using the sustained-release anti-allergic preparation of the present invention, specifically, as shown in FIG. 1, the granular anti-allergic preparation 1 of the present invention is enclosed in a breathable package, By putting this package in the pocket of the mask 2 and attaching it, by the exhilaration of menthol,
The nose is smooth and is suitable for pollen seasons.
【００４３】また、図２に示したように、本発明の粒状
である抗アレルギー製剤１を通気性のパッケージに封入
し、このパッケージを枕又は枕カバー３のポケットに入
れて取り付けることにより、爽快感と清涼感を付与し、
安眠を得ることができるものである。Also, as shown in FIG. 2, the granular antiallergic preparation 1 of the present invention is sealed in a breathable package, and the package is placed in a pillow or a pillow cover 3 to be attached to the package. Gives a sense of coolness and coolness,
You can get a good night's sleep.
【００４４】なお、本発明徐放性抗アレルギー剤又は徐
放性抗アレルギー製剤の用途は、上記の例に限られず、
他にも種々の用途に用いることができる。例えば、以下
のような利用が可能である。 （１）居室、トイレット、車内等の空間に噴霧するスプ
レーへの配合。 （２）家畜や愛玩動物の飼料用具へ噴霧するスプレーへ
の配合。 （３）台所等の生ゴミの除菌、消臭処理。The use of the sustained release antiallergic agent or the sustained release antiallergic preparation of the present invention is not limited to the above examples.
It can be used for various other uses. For example, the following use is possible. (1) Formulation into a spray that sprays into spaces such as living rooms, toilets, and vehicles. (2) Incorporation into a spray for spraying livestock and pet animal feed implements. (3) Disinfection and deodorization of kitchen garbage.
【００４５】[0045]
【実施例】以下、実施例を示し、本発明をより具体的に
説明するが、本発明は下記実施例に制限されるものでは
ない。EXAMPLES The present invention will be described below more specifically with reference to examples, but the present invention is not limited to the following examples.
【００４６】〔実施例１〕 徐放性試験 ５ｃｍ×５ｃｍのガーゼを電子天秤の上に載せ、下記に
示した試験液をそれぞれ０．５ｍＬしみ込ませ、１５分
ごとに質量を測定し、最初の質量（０分）を１００％と
して百分率で表した。結果を表１に示す。なお、測定
は、２３℃、湿度６７％の室内で行った。Example 1 Sustained Release Test A gauze of 5 cm × 5 cm was placed on an electronic balance, and 0.5 mL of each of the test solutions shown below was impregnated, and the mass was measured every 15 minutes. The mass (0 min) was expressed as a percentage, assuming 100%. Table 1 shows the results. The measurement was performed in a room at 23 ° C. and a humidity of 67%.
【００４７】<試験液> （１）ｄｌ−メントール （２）ｄｌ−メントール＋オリーブ油〔１：１（質量
比）〕 （３）ｄｌ−メントール＋オリーブ油＋桂皮油〔１：
１：１（質量比）〕 （４）ｄｌ−メントール＋オリーブ油＋桂皮油〔１：
０．５：０．５（質量比）〕 （５）オリーブ油 （６）グリセリン （７）水<Test liquid> (1) dl-menthol (2) dl-menthol + olive oil [1: 1 (mass ratio)] (3) dl-menthol + olive oil + cinnamon oil [1:
1: 1 (mass ratio)] (4) dl-menthol + olive oil + cinnamon oil [1:
0.5: 0.5 (mass ratio)] (5) Olive oil (6) Glycerin (7) Water
【００４８】[0048]
【表１】 [Table 1]
【００４９】〔実施例２〕 マスク試験 アレルギー症状のある２３歳〜４３歳の男女１０名ずつ
計２０名を４群、各５名に分け、前記（１）〜（４）の
試験液についてそれぞれ１ｇを毎日使用開始前にしみ込
ませた市販のマスクを１週間１日６時間装着し、その
際、鼻詰まりの改善、くしゃみの改善、においの持続
性、装着の不快感について下記基準で評価を行った。Example 2 Mask test Ten groups of 20 men and women aged 23 to 43 with allergic symptoms were divided into 4 groups, each of which was divided into 5 groups. The test solutions of (1) to (4) were Wear a commercially available mask, in which 1 g was soaked every day before use, for 6 hours a day for 1 week. At that time, the following criteria were used to evaluate the improvement of nasal congestion, improvement of sneezing, persistence of smell, and discomfort of wearing. went.
【００５０】また、マスク装着時の芳香性について下記
基準で評価した。結果を表２に示す。なお、（１）の試
験液はメントールのにおいが強すぎるため、１日６時間
マスクを装着することが困難であり、その間室温に放置
して６時間後に、においの持続性を評価した。The fragrance at the time of wearing the mask was evaluated according to the following criteria. Table 2 shows the results. In addition, since the test solution of (1) had too strong a menthol smell, it was difficult to wear a mask for 6 hours a day. During that time, it was left at room temperature for 6 hours, and the persistence of the smell was evaluated.
【００５１】<評価基準> ５点：大変良い ４点：良い ３点：普通 ２点：悪い １点：大変悪い<Evaluation criteria> 5 points: very good 4 points: good 3 points: normal 2 points: bad 1 point: very bad
【００５２】<芳香性> ◎：まろやかで極めて良好 ○：良好 △：やや劣る ×：劣る<Aromaticity> ：: mellow and extremely good ：: good △: slightly poor ×: poor
【００５３】[0053]
【表２】 [Table 2]
【００５４】表２の結果から、植物性精油とｄｌ−メン
トールを有効成分として含有する抗アレルギー剤
〔（２），（３），（４）〕は、装着の不快感を与える
ことなく、においの持続性があり、良好な芳香性を有
し、鼻詰まり、くしゃみなどのアレルギー症状の緩和効
果が認められる。From the results in Table 2, it can be seen that the antiallergic agents [2], [3], and [4] containing vegetable essential oil and dl-menthol as active ingredients do not give any discomfort during wearing and smell. It has a long lasting effect, has good aromatic properties, and has an alleviating effect on allergic symptoms such as nasal congestion and sneezing.
【００５５】〔実施例３〕 持続性試験 平均粒径約２ｍｍの多孔質体（セルロース粒子）を用い
て製造した下記配合組成の抗アレルギー製剤を通気性袋
体（不織布製：４ｃｍ×４ｃｍ）に収納して、徐放性抗
アレルギー製剤を得た。この徐放性抗アレルギー製剤
と、前記試験液（４）の徐放性抗アレルギー剤を用い
て、実施例２と同様の試験を行った。但し、徐放性抗ア
レルギー剤又は徐放性抗アレルギー製剤のマスクへの担
持方法は、試験開始時のみに行うものとする。結果を表
３に示す。Example 3 Persistence Test An antiallergic preparation having the following composition produced by using a porous material (cellulose particles) having an average particle size of about 2 mm was put into a breathable bag (4 cm × 4 cm made of nonwoven fabric). After storage, a sustained-release antiallergic preparation was obtained. The same test as in Example 2 was conducted using this sustained release antiallergic preparation and the sustained release antiallergic agent of the test solution (4). However, the method of loading the sustained-release anti-allergic agent or the sustained-release anti-allergic preparation on the mask shall be performed only at the start of the test. Table 3 shows the results.
【００５６】 <粒状抗アレルギー製剤の配合組成> 前記（４）の試験液 ０．５ｍＬ セルロース粒子 ０．６ｇ パラフィンワックス ０．９ｇ<Blending composition of granular antiallergic preparation> Test liquid of the above (4) 0.5 mL Cellulose particles 0.6 g Paraffin wax 0.9 g
【００５７】<評価基準> ◎：初期と変化なし ○：初期とほとんど変化なし △：初期より低下あり ×：著しい低下あり<Evaluation Criteria> 初期: No change from the initial state ほ と ん ど: Little change from the initial state
【００５８】[0058]
【表３】 [Table 3]
【００５９】表３の結果から、混練材を混練して得た本
発明の抗アレルギー製剤は、鼻詰まり、くしゃみなどの
アレルギー症状の緩和効果や、におい、芳香性の全てに
おいて、徐放性抗アレルギー剤に比べて持続性がより高
く、その効果は２週間程度持続した。From the results shown in Table 3, the antiallergic preparation of the present invention obtained by kneading the kneading material has a sustained-release antiallergic effect in alleviating allergic symptoms such as nasal congestion and sneezing, and in all of the odor and fragrance. It was more persistent than allergic drugs, and the effect lasted for about two weeks.
【００６０】 〔実施例４〕 スプレー 下記配合の抗アレルギー用スプレーを作製した。 ｄｌ−メントール ０．１質量％ オリーブ油 ０．１質量％ 桂皮油 ０．１質量％ クエン酸 １．０質量％ クエン酸三ナトリウム ０．８質量％ エタノール ２０．０質量％ 水 残部 計 １００．０質量％Example 4 Spray An antiallergic spray having the following composition was prepared. dl-menthol 0.1 mass% olive oil 0.1 mass% cinnamon oil 0.1 mass% citric acid 1.0 mass% trisodium citrate 0.8 mass% ethanol 20.0 mass% water balance 100.0 mass %
【００６１】[0061]
【発明の効果】以上説明したように、本発明によれば、
植物性精油とｄｌ−メントールを有効成分として含有す
る徐放性抗アレルギー剤、該徐放性抗アレルギー剤を粒
状化、又は基体に含浸させてなる徐放性抗アレルギー製
剤、若しくは前記徐放性抗アレルギー剤を混練材と混練
し、得られた混練物を造粒、又は基体に担持させてなる
徐放性抗アレルギー製剤が、メントールの刺激臭をまろ
やかにすることができると共に、優れた持続性を有し、
鼻詰まり感、くしゃみ等のアレルギー症状を効果的に緩
和、改善することができるものである。As described above, according to the present invention,
A sustained-release antiallergic agent containing a vegetable essential oil and dl-menthol as active ingredients, a sustained-release antiallergic preparation obtained by granulating or impregnating the sustained-release antiallergic agent, or the sustained release agent An anti-allergic agent is kneaded with a kneading material, and the resulting kneaded product is granulated, or a sustained-release anti-allergic preparation obtained by being supported on a base can provide a mild irritating odor of menthol and have excellent sustainability. Has the nature
It can effectively alleviate and improve allergic symptoms such as nasal congestion and sneezing.
【図１】マスクに本発明の徐放性抗アレルギー製剤を装
着する状態を示す概略図である。FIG. 1 is a schematic view showing a state where a sustained-release antiallergic preparation of the present invention is mounted on a mask.
【図２】枕及び枕カバーに本発明の徐放性抗アレルギー
製剤を装着する状態を示す概略図である。FIG. 2 is a schematic view showing a state where the sustained-release antiallergic preparation of the present invention is mounted on a pillow and a pillow cover.
１ 徐放性抗アレルギー製剤 ２ マスク ３ 枕 1 Sustained release antiallergic preparation 2 Mask 3 Pillow
───────────────────────────────────────────────────── フロントページの続き (72)発明者 亀井 清 福井県坂井郡金津町自由ヶ丘１丁目８番10 号 レンゴー株式会社福井研究所内 (72)発明者 斎藤 秀直 福井県坂井郡金津町自由ヶ丘１丁目８番10 号 レンゴー株式会社福井研究所内 Ｆターム(参考） 4C084 AA03 BA46 CA13 MA02 MA13 MA59 NA12 NA14 ZB13 4C206 AA01 AA02 CA17 KA01 MA03 MA33 MA79 NA12 NA14 ZB13 ──────────────────────────────────────────────────続 き Continuing on the front page (72) Kiyoshi Kamei, 1-8-10 Jiyugaoka, Kanazu-cho, Sakai-gun, Fukui Prefecture Inside Fukui Research Laboratory of Rengo Co., Ltd. (72) Hidenao Saito 1-8-8, Jiyugaoka, Kanazu-cho, Sakai-gun, Fukui Prefecture No. 10 F-term in Rengo Co., Ltd. Fukui Research Laboratory 4C084 AA03 BA46 CA13 MA02 MA13 MA59 NA12 NA14 ZB13 4C206 AA01 AA02 CA17 KA01 MA03 MA33 MA79 NA12 NA14 ZB13
Claims (11)
分として含有することを特徴とする徐放性抗アレルギー
剤。1. A sustained-release anti-allergic agent comprising a vegetable essential oil and dl-menthol as active ingredients.
ホバ油、ひまし油、ツバキ油、月見草油、サフラワー
油、ベニバナ油、落花生油、スクワラン、ベルガモット
油、アボガド油、ひまわり油、ユーカリ油、テレピン
油、カカオ油、ローズ油、トウモロコシ油、ナタネ油、
綿実油、椰子油及びケシ油から選ばれる１種又は２種以
上である請求項１記載の徐放性抗アレルギー剤。2. The vegetable essential oils include olive oil, cinnamon oil, jojoba oil, castor oil, camellia oil, evening primrose oil, safflower oil, safflower oil, peanut oil, squalane, bergamot oil, avocado oil, sunflower oil, eucalyptus oil, Turpentine oil, cocoa oil, rose oil, corn oil, rapeseed oil,
2. The sustained-release antiallergic agent according to claim 1, wherein the agent is one or more selected from cottonseed oil, coconut oil and poppy oil.
を有効成分として含有する請求項１又は２記載の徐放性
抗アレルギー剤。3. The sustained-release antiallergic agent according to claim 1, which comprises olive oil, cinnamon oil and dl-menthol as active ingredients.
を、質量比でオリーブ油：桂皮油：ｄｌ−メントール＝
１〜１０：１〜１０：１〜１０の割合で含む請求項３記
載の徐放性抗アレルギー剤。4. Olive oil, cinnamon oil and dl-menthol in a mass ratio of olive oil: cinnamon oil: dl-menthol =
4. The sustained-release antiallergic agent according to claim 3, comprising 1 to 10: 1 to 10: 1 to 10 in a ratio.
放性抗アレルギー剤を粒状化、又は基体に含浸させたこ
とを特徴とする徐放性抗アレルギー製剤。5. A sustained-release anti-allergic preparation characterized in that the sustained-release anti-allergic agent according to claim 1 is granulated or impregnated in a substrate.
放性抗アレルギー剤を混練材と混練し、得られた混練物
を造粒、又は基体に担持させたことを特徴とする徐放性
抗アレルギー製剤。6. A method according to claim 1, wherein the sustained-release antiallergic agent according to any one of claims 1 to 4 is kneaded with a kneading material, and the obtained kneaded product is granulated or supported on a substrate. Sustained release antiallergic preparation.
放性抗アレルギー剤の合計有効成分量と混練材との混合
割合が、質量比で合計有効成分量：混練材＝１：０．１
〜１０．０である請求項６記載の徐放性抗アレルギー製
剤。7. The mixing ratio between the total amount of the active ingredient of the sustained-release antiallergic agent according to any one of claims 1 to 4 and the kneading material is represented by mass ratio of the total amount of the active ingredient: kneading material = 1: 1. 0.1
7. The sustained-release antiallergic preparation according to claim 6, wherein the amount is from 10.0 to 10.0.
いずれか１項記載の徐放性抗アレルギー製剤。8. The sustained-release antiallergic preparation according to claim 5, wherein the substrate is a porous body.
放性抗アレルギー剤、又は請求項５乃至８のいずれか１
項記載の徐放性抗アレルギー製剤を一部又は全部に備え
たことを特徴とする日常衛生用品。9. The sustained-release antiallergic agent according to any one of claims 1 to 4, or any one of claims 5 to 8.
A daily hygiene article comprising a part or all of the sustained-release antiallergic preparation according to the above item.
徐放性抗アレルギー製剤を封入したパッケージを取付け
たことを特徴とする日常衛生用品。10. A daily hygiene article provided with a package enclosing the sustained-release antiallergic preparation according to any one of claims 5 to 8.
ガーゼ、包帯、タオル、ハンカチ、おしぼり、ティッシ
ュ、ウエットティッシュ、オムツ、手袋、下着、白衣、
手術着、パジャマ、ネグリジェ、スエットスーツ、シー
ツ、ベッドカバー、ベッドパッド、ベッド、布団、毛
布、タオルケット、ソファー、枕及び枕カバーから選ば
れる請求項９又は１０記載の日常衛生用品。11. The daily hygiene article includes a mask, a nasal tape,
Gauze, bandage, towel, handkerchief, towel, tissue, wet tissue, diaper, gloves, underwear, lab coat,
The daily hygiene article according to claim 9 or 10, selected from surgical gowns, pajamas, negligee, sweat suits, sheets, bedspreads, bed pads, beds, futons, blankets, towels, sofas, pillows and pillowcases.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001184373A JP4965772B2 (en) | 2001-06-19 | 2001-06-19 | Sustained release antiallergic agent, sustained release antiallergic preparation and daily hygiene products using the antiallergic agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001184373A JP4965772B2 (en) | 2001-06-19 | 2001-06-19 | Sustained release antiallergic agent, sustained release antiallergic preparation and daily hygiene products using the antiallergic agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002370974A true JP2002370974A (en) | 2002-12-24 |
| JP4965772B2 JP4965772B2 (en) | 2012-07-04 |
Family
ID=19024140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001184373A Expired - Fee Related JP4965772B2 (en) | 2001-06-19 | 2001-06-19 | Sustained release antiallergic agent, sustained release antiallergic preparation and daily hygiene products using the antiallergic agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4965772B2 (en) |
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| ITFI20090023A1 (en) * | 2009-01-30 | 2010-07-31 | Delicarta Spa | "A PAPER CRAFTS IN A PAPER MATERIAL CONTAINING A SUPPORTING SUBSTANCE IN THE TREATMENT OF ALLERGIC RINITIS" |
| CN103536961A (en) * | 2013-11-07 | 2014-01-29 | 邢文 | Medical cold compress bandage and production method thereof |
| CN103622181A (en) * | 2013-11-29 | 2014-03-12 | 菏泽巨鑫源食品有限公司 | Method for manufacturing anti-freezing and anti-cracking type PVC gloves |
| CN105078105A (en) * | 2015-07-29 | 2015-11-25 | 邢楠楠 | Healthcare traditional Chinese salt pillow |
| CN106235817A (en) * | 2016-08-12 | 2016-12-21 | 张太平 | A kind of functional quilt core and processing technique thereof |
| KR20180082931A (en) * | 2017-01-11 | 2018-07-19 | 농업회사법인주식회사니파바이오 | Funtional underwear with nipa fruticans wurmb |
| CN111869957A (en) * | 2020-07-13 | 2020-11-03 | 黑龙江东方学院 | Fungi-proofing fog-absorbing mask |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105996629A (en) * | 2016-04-29 | 2016-10-12 | 安徽省舒城县福来童车有限公司 | Baby carriage back pillow core |
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| CN111869957A (en) * | 2020-07-13 | 2020-11-03 | 黑龙江东方学院 | Fungi-proofing fog-absorbing mask |
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|---|---|
| JP4965772B2 (en) | 2012-07-04 |
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