JP2002326961A - Lubricant for making tablet - Google Patents
Lubricant for making tabletInfo
- Publication number
- JP2002326961A JP2002326961A JP2001133456A JP2001133456A JP2002326961A JP 2002326961 A JP2002326961 A JP 2002326961A JP 2001133456 A JP2001133456 A JP 2001133456A JP 2001133456 A JP2001133456 A JP 2001133456A JP 2002326961 A JP2002326961 A JP 2002326961A
- Authority
- JP
- Japan
- Prior art keywords
- tableting
- lubricant
- present
- tablet
- polysaccharide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は打錠する際に結着
力、滑沢性を高めることにより、キャッピング、スティ
ッキング及びバインディング等を防止する打錠用滑沢剤
及びそれを用いた錠剤または錠菓に関するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a tableting lubricant for preventing capping, sticking, binding and the like by enhancing the binding force and lubricity during tableting, and a tablet or tablet confection using the same. It is about.
【０００２】[0002]
【従来の技術】錠剤、錠菓において、粉末や粉状の原料
を打錠する必要がある。打錠においては、脱型の際に錠
剤の上杵側に帽子状にはがれるキャッピング、打錠中に
粉が杵に付着し杵離れが悪く、錠剤表面に傷がつくステ
ィッキング、錠剤と臼の摩擦が大きく打錠後の錠剤の排
出性が悪くなるバインディングを生じることがあり、こ
れらがひどくなるとスムーズに打錠できなくなる。そこ
で打錠においては滑沢剤を使用することにより、原料粉
体の流動性を向上させ、打錠機の臼に一定量が充填され
るようにすると同時に、打錠の際のキャッピング、ステ
ィッキング及びバインディング等を防止し、打錠の表面
に光沢を与えるために従来から精製タルク、ステアリン
酸マグネシウム、植物硬化油、ポリグリセリン脂肪酸エ
ステルやショ糖脂肪酸エステルなどの食品用乳化剤等が
滑沢剤として使用されてきた。しかしながら、ステアリ
ン酸マグネシウムは、少量の使用で滑沢剤としての効果
を出すことができるが、食品添加物として認められてい
ないためその用途が医薬品に限定される。精製タルク
は、食品への使用量に制限があり、また滑沢剤としての
効果も小さいためあまり用いられない。また、食品用乳
化剤は滑沢剤の効果が小さいため、充分な効果を期待す
るためには多量に添加しなければならず、そのために錠
剤の硬度低下や風味を悪くしたりする等の問題があっ
た。2. Description of the Related Art In tablets and confectionery, it is necessary to compress powder or powdery raw materials. In tableting, capping comes off in the form of a hat on the upper punch side of the tablet during demolding, powder sticks to the punch during tableting, sticking away from the punch, sticking to the tablet surface, sticking, friction between tablet and die In some cases, the binding of the tablet may become poor after tableting, and the tablet may not be discharged smoothly. Therefore, in tableting, a lubricant is used to improve the fluidity of the raw material powder so that a certain amount is filled in a die of a tableting machine, and at the same time capping, sticking and Conventionally used lubricating agents such as purified talc, magnesium stearate, hardened vegetable oils, and food-grade emulsifiers such as polyglycerin fatty acid esters and sucrose fatty acid esters to prevent binding etc. and give the tablet surface a gloss. It has been. However, although magnesium stearate can exert its effect as a lubricant with a small amount of use, its use is limited to pharmaceuticals because it is not recognized as a food additive. Purified talc is rarely used because of its limited use in foods and its small effect as a lubricant. In addition, since a food emulsifier has a small effect of a lubricant, it must be added in a large amount in order to expect a sufficient effect, and therefore, there are problems such as a decrease in hardness of a tablet and a deterioration in flavor. there were.
【０００３】[0003]
【発明が解決しようとする課題】本発明は従来の問題を
解決すべくなされたもので、錠剤、錠菓を打錠する際に
結着力、滑沢性を高めることにより、キャッピング、ス
ティッキング及びバインディングを防止する打錠用滑沢
剤を提供することを目的とする。DISCLOSURE OF THE INVENTION The present invention has been made to solve the conventional problems, and it is intended to increase the binding force and lubricity when compressing tablets and confections, thereby providing capping, sticking and binding. An object of the present invention is to provide a tableting lubricant for preventing tableting.
【０００４】[0004]
【課題を解決するための手段】本発明者は前記課題を解
決すべく鋭意研究を重ねた結果、植物抽出多糖類を使用
することによって、結着力、滑沢性を高め、キャッピン
グ、スティッキング及びバインディングが防止できるこ
とを見出し、本発明に至った。すなわち本発明は、植物
抽出多糖類を含有することを特徴とする打錠用滑沢剤に
関するものである。以下、本発明を詳細に説明する。The present inventors have conducted intensive studies to solve the above-mentioned problems, and as a result, by using plant-extracted polysaccharides, the binding power and lubricity have been improved, and capping, sticking and binding have been carried out. It has been found that this can be prevented, and the present invention has been achieved. That is, the present invention relates to a tableting lubricant comprising a plant-extracted polysaccharide. Hereinafter, the present invention will be described in detail.
【０００５】[0005]
【発明の実施の態様】本発明における滑沢剤とは、原料
粉体の流動性を向上させ、打錠機の臼に一定量が充填さ
れるようにするとともに、原料粉体自体の結着力を向上
させ、打錠時の剥離、割れを防止し、それらの結果、キ
ャッピング、スティッキング及びバインディングを防止
し、錠剤の表面に光沢を与え、安定な錠剤を得るために
用いられる添加物である。本発明における植物抽出多糖
類は特に限定するものではないが果実、豆科などの植物
から抽出された多糖類で、その中でも大豆多糖類、ペク
チン及びグアーガムからなる群より選ばれる少なくとも
１種以上であることが好ましく、最も好ましい植物抽出
多糖類は水溶性大豆多糖類である。本発明における大豆
多糖類とは、大豆より抽出、精製した水溶性もしくは不
溶性多糖類であり、大豆由来の食物繊維である。本発明
におけるグアーガムとはグアー種子より抽出された多糖
類で、酵素分解物も含む。本発明におけるペクチンとは
果実、野菜などに広く存在し、主として柑橘系果実また
は林檎の果実から分離、精製される多糖類である。本発
明における食品用乳化剤は特に限定するものではないが
グリセリン脂肪酸エステル、プロピレングリコール脂肪
酸エステル、ソルビタン脂肪酸エステル、ショ糖脂肪酸
エステルなどが例として挙げられ、その中でもポリグリ
セリン脂肪酸エステル及びショ糖脂肪酸エステルからな
る群より選ばれる少なくとも１種以上であることが好ま
しい。BEST MODE FOR CARRYING OUT THE INVENTION A lubricant in the present invention is intended to improve the fluidity of a raw material powder so that a certain amount is filled in a die of a tableting machine, and a binding force of the raw material powder itself. Is an additive used for improving tableting, preventing peeling and cracking during tableting, thereby preventing capping, sticking and binding, imparting gloss to the tablet surface, and obtaining a stable tablet. The plant-extracted polysaccharide in the present invention is not particularly limited, but is a fruit, a polysaccharide extracted from plants such as legumes, and among them, at least one or more selected from the group consisting of soybean polysaccharide, pectin and guar gum. Preferably, the most preferred plant-extracted polysaccharide is a water-soluble soy polysaccharide. The soybean polysaccharide in the present invention is a water-soluble or insoluble polysaccharide extracted and purified from soybean, and is a dietary fiber derived from soybean. Guar gum in the present invention is a polysaccharide extracted from guar seeds, and includes enzymatic degradation products. The pectin in the present invention is a polysaccharide widely present in fruits, vegetables and the like and mainly separated and purified from citrus fruits or apple fruits. The food emulsifier in the present invention is not particularly limited, but glycerin fatty acid ester, propylene glycol fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester and the like are exemplified, and among them, polyglycerin fatty acid ester and sucrose fatty acid ester It is preferable that at least one selected from the group consisting of
【０００６】ここで、ポリグリセリン脂肪酸エステルは
特に限定するものではないが、ポリグリセリンの脂肪酸
炭素数１０〜２２、ポリグリセリンの重合度２〜２０、
水酸基価が１００未満であることが好ましい。炭素数９
以下のポリグリセリン脂肪酸エステルの場合には、その
融点が低くなりすぎるため微粉末にはならず、打錠用滑
沢剤としての効果は不充分となる。また、炭素数２３以
上のポリグリセリン脂肪酸エステルでは、これを使用し
て製造した錠剤、錠菓の硬度を低下させるため使用に適
さない。また、重合度が２１以上のポリグリセリンは、
原料自体の粘度が高すぎてエステル反応が著しく困難と
なるため、実用的でない。また、エステルの水酸基価が
１００以上であると打錠機への付着等により製品歩留ま
りが低下する。また、本発明のショ糖脂肪酸エステルは
特に限定するものではないがショ糖脂肪酸の炭素数が８
〜２２、平均置換度が２以上であることが好ましい。炭
素数８以下では融点が低くなりすぎるため微粉末にはな
らず、打錠用滑沢剤としての効果は不充分となる。ま
た、炭素数２２以上では、これを使用して製造した打錠
用滑沢剤は錠剤、錠菓の硬度を低下させる。平均置換度
２以下のショ糖脂肪酸エステルでは打錠機への付着等に
より製品歩留まりが悪くなる。Here, the polyglycerin fatty acid ester is not particularly limited, but the fatty acid carbon number of polyglycerin is 10 to 22, the polymerization degree of polyglycerin is 2 to 20, and
Preferably, the hydroxyl value is less than 100. Carbon number 9
In the case of the following polyglycerin fatty acid esters, their melting points are too low, so that they do not become fine powder, and the effect as a tableting lubricant becomes insufficient. Further, polyglycerol fatty acid esters having 23 or more carbon atoms are not suitable for use because the hardness of tablets and confections produced using the same is reduced. The polyglycerin having a degree of polymerization of 21 or more is
It is not practical because the viscosity of the raw material itself is too high and the ester reaction becomes extremely difficult. Further, when the hydroxyl value of the ester is 100 or more, the product yield decreases due to adhesion to a tableting machine and the like. The sucrose fatty acid ester of the present invention is not particularly limited, but the sucrose fatty acid has 8 carbon atoms.
~ 22, the average degree of substitution is preferably 2 or more. If the number of carbon atoms is 8 or less, the melting point is too low, so that the powder does not become fine powder, and the effect as a tableting lubricant becomes insufficient. When the number of carbon atoms is 22 or more, a tableting lubricant produced using the same reduces the hardness of tablets and confectionery. In the case of sucrose fatty acid esters having an average degree of substitution of 2 or less, the product yield is deteriorated due to adhesion to a tableting machine or the like.
【０００７】本発明の打錠用滑沢剤の植物抽出多糖類と
食品用乳化剤の割合は特に限定するものではないが、植
物抽出多糖類：食品用乳化剤＝１０：９０〜９０：１０
が好ましい。より好ましくは植物抽出多糖類：食品乳化
剤＝２０：８０〜８０：２０である。また本発明の打錠
用滑沢剤の粒径は特に限定するものではないが、粒径が
大きいと均一に分散せず流動性及び製品の歩留まりが低
下するので２５０μｍ以下であることが好ましい。本発
明における錠剤または錠菓の製造の製造過程は、特に限
定するものではないが、圧縮成型するための粉末または
顆粒を製造する造粒プロセスと圧縮成型する打錠プロセ
スに分けられ、本発明における打錠用滑沢剤は一般に造
粒プロセス後に添加されるのが好ましい。また、その添
加量は特に限定するものではないが、０．２％〜５重量
％が好ましい。本発明における打錠用滑沢剤の製造法
は、特に限定するものではないが、例えば直接錠剤製造
法、湿式錠剤製造法を用いることができる。以下に本発
明の実施例を示すが、本発明はこれらのみに限定される
ものではない。なお、評価は肉眼観察により行った。[0007] The ratio of the plant-extracted polysaccharide to the food emulsifier of the tableting lubricant of the present invention is not particularly limited, but the plant-extracted polysaccharide: food emulsifier = 10:90 to 90:10.
Is preferred. More preferably, the ratio of plant-extracted polysaccharide: food emulsifier is 20:80 to 80:20. The particle size of the tableting lubricant of the present invention is not particularly limited, but if the particle size is large, the lubricant is not uniformly dispersed and the fluidity and the yield of the product are reduced. The manufacturing process of tablet or confectionery production in the present invention is not particularly limited, and is divided into a granulation process for producing powder or granules for compression molding and a tableting process for compression molding. It is generally preferred that the tableting lubricant be added after the granulation process. Further, the amount of addition is not particularly limited, but is preferably 0.2% to 5% by weight. The method for producing the tableting lubricant in the present invention is not particularly limited, and for example, a direct tablet production method or a wet tablet production method can be used. Examples of the present invention will be described below, but the present invention is not limited to these. In addition, evaluation was performed by visual observation.
【０００８】[0008]
【実施例】実施例１ 原料を表１の割合で混合し本発明品（打錠用滑沢剤）１
〜６をそれぞれ２０ｇ調製した。EXAMPLES Example 1 Raw materials were mixed in the proportions shown in Table 1 to produce a product of the present invention (a lubricant for tableting) 1
To 6 were each prepared in an amount of 20 g.
【０００９】[0009]
【表１】 [Table 1]
【００１０】比較例１ 表２の原料を用いて比較品（打錠用滑沢剤）１〜４をそ
れぞれ２０ｇ調製した。Comparative Example 1 Using the raw materials shown in Table 2, 20 g of each of comparative products (lubricants for tableting) 1 to 4 were prepared.
【００１１】[0011]
【表２】 [Table 2]
【００１２】試験例１ 乳糖８００ｇ、粉糖１８０ｇ、本発明品または比較品２
０ｇを混合後、直接打錠法により打錠機で一定の成型圧
力を加えて３００ｍｇ±８／錠で打錠を行った。打錠時
間は１０分とし、キャッピング、スティッキング及びバ
インディングの評価を肉眼観察により行った。結果を表
３に示す。Test Example 1 Lactose 800 g, powdered sugar 180 g, product of the present invention or comparative product 2
After mixing 0 g, a constant tableting pressure was applied by a tableting machine by a direct tableting method to perform tableting at 300 mg ± 8 / tablet. The tableting time was 10 minutes, and capping, sticking and binding were evaluated by visual observation. Table 3 shows the results.
【００１３】[0013]
【表３】 [Table 3]
【００１４】表３の評価結果より明らかなように本発明
による植物抽出多糖類を含有することを特徴とする打錠
用滑沢剤は従来品に比べて結着力、滑沢性を高めること
により、キャッピング、スティッキング及びバインディ
ングを起こさない錠剤・錠菓が得られる。As is clear from the evaluation results in Table 3, the lubricant for tableting characterized by containing the plant-extracted polysaccharide according to the present invention has improved binding power and lubricity as compared with conventional products. , Tablets and confections which do not cause capping, sticking and binding are obtained.
【００１５】[0015]
【発明の効果】本発明によれば、錠剤、錠菓を打錠する
際に結着力、滑沢性を高めることにより、キャッピン
グ、スティッキング及びバインディングを防止する打錠
用滑沢剤を得ることが出来る。According to the present invention, a tableting lubricant capable of preventing capping, sticking and binding can be obtained by increasing the binding force and lubricity when tableting tablets and confectionery. I can do it.
フロントページの続き (72)発明者 加藤 友治 三重県四日市市赤堀新町９番５号 太陽化 学株式会社内 (72)発明者 山崎 長宏 三重県四日市市赤堀新町９番５号 太陽化 学株式会社内 Ｆターム(参考） 4B014 GB08 GE02 GK12 GL11 GQ05 GY01 4C076 AA36 BB01 DD46F EE30C FF09 Continuation of the front page (72) Inventor Yuji Kato 9-5 Akabori Shinmachi, Yokkaichi-shi, Mie Taiyo Chemical Co., Ltd. (72) Inventor Nagahiro 9-5 Akabori Shinmachi, Yokkaichi-shi, Mie Taiyo Chemical Co., Ltd. F term (reference) 4B014 GB08 GE02 GK12 GL11 GQ05 GY01 4C076 AA36 BB01 DD46F EE30C FF09
Claims (6)
する打錠用滑沢剤。1. A tableting lubricant comprising a plant-extracted polysaccharide.
することを特徴とする打錠用滑沢剤。2. A tableting lubricant comprising a plant-extracted polysaccharide and a food emulsifier.
及びグアーガムからなる群より選ばれる少なくとも１種
以上である請求項１または２記載の打錠用滑沢剤。3. The tableting lubricant according to claim 1, wherein the plant-extracted polysaccharide is at least one member selected from the group consisting of soybean polysaccharide, pectin, and guar gum.
を特徴とする請求項１〜３いずれか記載の打錠用滑沢
剤。4. The tableting lubricant according to claim 1, which is a powder having a particle size of 250 μm or less.
剤を含有することを特徴とする錠剤。5. A tablet comprising the tableting lubricant according to any one of claims 1 to 4.
剤を含有することを特徴とする錠菓。6. A tablet confection comprising the tableting lubricant according to any one of claims 1 to 4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001133456A JP2002326961A (en) | 2001-04-27 | 2001-04-27 | Lubricant for making tablet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001133456A JP2002326961A (en) | 2001-04-27 | 2001-04-27 | Lubricant for making tablet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2002326961A true JP2002326961A (en) | 2002-11-15 |
Family
ID=18981315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001133456A Pending JP2002326961A (en) | 2001-04-27 | 2001-04-27 | Lubricant for making tablet |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2002326961A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS51148066A (en) * | 1975-05-26 | 1976-12-18 | Furointo Sangiyou Kk | Method of producing tablet confection |
| JPH03200724A (en) * | 1989-02-21 | 1991-09-02 | Norwich Eaton Pharmaceut Inc | Tablet having double action |
| JPH10298061A (en) * | 1997-04-25 | 1998-11-10 | Tanabe Seiyaku Co Ltd | Shaped preparation and its production |
| JP2000178206A (en) * | 1998-12-18 | 2000-06-27 | Fancl Corp | Lubricant containing plant fat and oil |
| JP2001103925A (en) * | 1999-10-05 | 2001-04-17 | Ajinomoto Co Inc | Solid sweetener composition and its use |
| JP2002188095A (en) * | 2000-12-21 | 2002-07-05 | Fancl Corp | Vegetable oil and fat powder and food composition containing the powder |
-
2001
- 2001-04-27 JP JP2001133456A patent/JP2002326961A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS51148066A (en) * | 1975-05-26 | 1976-12-18 | Furointo Sangiyou Kk | Method of producing tablet confection |
| JPH03200724A (en) * | 1989-02-21 | 1991-09-02 | Norwich Eaton Pharmaceut Inc | Tablet having double action |
| JPH10298061A (en) * | 1997-04-25 | 1998-11-10 | Tanabe Seiyaku Co Ltd | Shaped preparation and its production |
| JP2000178206A (en) * | 1998-12-18 | 2000-06-27 | Fancl Corp | Lubricant containing plant fat and oil |
| JP2001103925A (en) * | 1999-10-05 | 2001-04-17 | Ajinomoto Co Inc | Solid sweetener composition and its use |
| JP2002188095A (en) * | 2000-12-21 | 2002-07-05 | Fancl Corp | Vegetable oil and fat powder and food composition containing the powder |
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