JP2002323451A - Sterilization indicator composition - Google Patents
Sterilization indicator compositionInfo
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- JP2002323451A JP2002323451A JP2001167425A JP2001167425A JP2002323451A JP 2002323451 A JP2002323451 A JP 2002323451A JP 2001167425 A JP2001167425 A JP 2001167425A JP 2001167425 A JP2001167425 A JP 2001167425A JP 2002323451 A JP2002323451 A JP 2002323451A
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- sterilization
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- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、例えば病院等で行
われる医療用機器等を滅菌するオートクレーブ滅菌処
理、エチレンオキサイドガス滅菌処理、過酸化水素低温
プラズマ滅菌処理、ホルマリン滅菌処理の各滅菌条件の
検知とその確認に適した滅菌検知用インジケータ組成物
に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to autoclave sterilization, ethylene oxide gas sterilization, hydrogen peroxide low-temperature plasma sterilization, and formalin sterilization for sterilizing medical equipment and the like performed in hospitals and the like. The present invention relates to an indicator composition for sterilization detection suitable for detection and confirmation thereof.
【０００２】[0002]
【従来の技術】医療分野において医療機器等を滅菌する
方法として、高圧蒸気で一定時間加熱を行うオートクレ
ーブ滅菌（以下ＡＣ滅菌）、エチレンオキサイドガスを
利用するエチレンオキサイドガス滅菌（以下ＥＯＧ滅
菌）、過酸化水素を利用する過酸化水素低温プラズマ滅
菌（以下ＰＳ滅菌）、ホルマリンガスを利用するホルマ
リン滅菌等が実用化している。滅菌処理完了の良否を確
認する方法としては、例えば耐熱菌（Ｂ、ｓｔｅａｒｏ
ｔｈｅｒｍｏｐｈｉｌｕｓ）や枯草菌（Ｂ、ｓｕｂｔｉ
ｌｉｓ）等を用いた生物化学的インジケータによって確
認する方法と、高圧蒸気、エチレンオキサイドガス、過
酸化水素、ホルマリンガス等の雰囲気と接触して化学反
応を起こして変色する、化学的インジケータによって確
認する方法とがある。2. Description of the Related Art In the medical field, methods for sterilizing medical equipment and the like include autoclave sterilization (hereinafter referred to as AC sterilization) in which heating is performed with high-pressure steam for a certain period of time, ethylene oxide gas sterilization using ethylene oxide gas (hereinafter referred to as EOG sterilization), and overheating. Hydrogen peroxide low temperature plasma sterilization (hereinafter, PS sterilization) using hydrogen oxide, formalin sterilization using formalin gas, and the like have been put to practical use. As a method for confirming the completion of the sterilization treatment, for example, heat-resistant bacteria (B, stearo)
thermophilus) and Bacillus subtilis (B, subti)
lis) and a biochemical indicator, and a chemical indicator that causes a chemical reaction upon contact with an atmosphere of high-pressure steam, ethylene oxide gas, hydrogen peroxide, formalin gas, etc. to cause discoloration. There is a way.
【０００３】前者の生物化学的インジケータは、正確な
滅菌の良否の確認が可能であるが、滅菌処理後に菌を培
養する必要があるため、滅菌の良否判定までに時間がか
かりすぎる。そのため、取り扱いが簡便で滅菌処理の良
否をリアルタイムで確認可能な、後者の化学的インジケ
ータが使われることが多い。化学的インジケータはその
多くが、紙やプラスチックフィルム等に印刷した形で使
用されている。例えば、高圧蒸気、エチレンオキサイド
ガス、過酸化水素、ホルマリンガス等と反応して変色す
るインジケータ組成物を、インキ化して印刷塗布したも
のである。その変色により滅菌処理の良否が判定され
る。[0003] The former biochemical indicator enables accurate confirmation of sterility. However, since it is necessary to culture bacteria after sterilization, it takes too much time to judge sterility. Therefore, the latter chemical indicator, which is easy to handle and can check the quality of sterilization in real time, is often used. Many of the chemical indicators are used in a form printed on paper, plastic film, or the like. For example, an indicator composition that changes color by reacting with high-pressure steam, ethylene oxide gas, hydrogen peroxide, formalin gas, or the like is formed into an ink and printed and applied. The quality of the sterilization process is determined based on the discoloration.
【０００４】特開昭６１−２８７９７２号公報、特開平
２−２１１１６２号公報、特開平２−１８０９７３号公
報には高圧蒸気に反応して変色するインジケータ組成物
が開示されている。特公昭５２−１００４３号公報、特
公昭５７−２４３１７３号公報、特開平２−１９１４６
２号公報、特公平０５−２８２７３号公報には、エチレ
ンオキサイドガスと反応して変色するインジケータ組成
物が開示されている。特開平４−３６４１７４号公報に
は高圧蒸気とエチレンオキサイドガスとに反応して変色
するインジケータ組成物が開示されている。特願平１０
−５４３７４３号公報には、過酸化水素プラズマにより
変色する、インジケータ組成物が開示されている。特開
平９−２６４２０号公報にはホルマリンガスと反応して
変色するインジケータ組成物が開示されている。[0004] JP-A-61-287972, JP-A-2-211162 and JP-A-2-180973 disclose an indicator composition which changes color in response to high-pressure steam. JP-B-52-10043, JP-B-57-243173, JP-A-2-19146.
No. 2, Japanese Patent Publication No. 05-28273 discloses an indicator composition which changes color when reacted with an ethylene oxide gas. JP-A-4-364174 discloses an indicator composition which changes color in response to high-pressure steam and ethylene oxide gas. Japanese Patent Application 10
-543743 discloses an indicator composition that changes its color by hydrogen peroxide plasma. Japanese Patent Application Laid-Open No. 9-26420 discloses an indicator composition that changes color when reacted with formalin gas.
【０００５】開示されているインジケータ組成物は高圧
蒸気、エチレンオキサイドガス、過酸化水素、ホルマリ
ンガスの何れか１種のものにしか反応しないインジケー
タ組成物である。特開平４−３６４１７４号公報開示の
インジケータ組成物は、ＡＣ滅菌とＥＯＧ滅菌に反応し
て変色するとされているがいまだ実用化されていない。
実際の滅菌処理作業では滅菌方法に対応する滅菌用イン
ジケータを用意して使い分ける必要があり不便である。
また、滅菌資材、例えば滅菌バッグ、滅菌テープ、滅菌
カード等を製造する際にも、おのおのに対応するインジ
ケータ組成物を準備して使い分ける必要があり不便であ
る。インジケータの用途を誤った場合は滅菌完了の確認
ができなくなり、作業上の無駄と煩雑さを強いられてい
る。また、在庫管理が煩雑になりがちである。The disclosed indicator composition is an indicator composition which reacts only with any one of high-pressure steam, ethylene oxide gas, hydrogen peroxide and formalin gas. The indicator composition disclosed in JP-A-4-364174 is said to discolor in response to AC sterilization and EOG sterilization, but has not yet been put to practical use.
In the actual sterilization operation, it is necessary to prepare and use a sterilization indicator corresponding to the sterilization method, which is inconvenient.
Also, when manufacturing sterilizing materials, for example, sterilizing bags, sterilizing tapes, sterilizing cards, etc., it is necessary to prepare and use the corresponding indicator compositions for each, which is inconvenient. If the indicator is used improperly, it is not possible to confirm the completion of sterilization, which imposes unnecessary work and complexity. In addition, inventory management tends to be complicated.
【０００６】[0006]
【発明が解決しようとする問題点】本発明は前記の課題
を解決するものであり、ＡＣ滅菌、ＥＯＧ滅菌、ＰＳ滅
菌、ホルマリン滅菌の何れの滅菌方法にも対応した変色
性を備えた滅菌インジケータ組成物を提供することを目
的とする。SUMMARY OF THE INVENTION The present invention has been made to solve the above-mentioned problems, and has a sterilization indicator having discoloration corresponding to any of the sterilization methods of AC sterilization, EOG sterilization, PS sterilization, and formalin sterilization. It is intended to provide a composition.
【０００７】[0007]
【問題を解決するための手段】前記の目的を達成するた
め本発明者は、分散染料の選択、有機酸の選択、樹脂の
精査、ビスマス化合物、硫黄を含む硫黄化合物等につい
て目的のインジケータを得るため鋭意研究を重ねた結
果、以下に示した組成物が目的と合致する滅菌インジケ
ータとなることを見出し、本発明を完成するに到った。In order to achieve the above object, the present inventor obtains an objective indicator for selecting a disperse dye, selecting an organic acid, examining a resin, bismuth compounds, sulfur compounds containing sulfur, and the like. Therefore, as a result of intensive studies, they have found that the composition shown below can be a sterilization indicator that meets the purpose, and have completed the present invention.
【０００８】即ち、本発明の滅菌インジケータ組成物
は、組成物１００重量部に分散染料Ｃ．Ｉディスパース
レッド５８、Ｃ．Ｉディスパースレッド１１０、Ｃ．Ｉ
ディスパースレッド１３７、Ｃ．Ｉディスパースバイオ
レッド４３から選ばれた１種以上の染料を０．０５〜３
重量部、有機酸を０．１〜５重量部、ビスマス化合物を
５〜１８重量部、硫黄もしくは硫黄化合物を１〜１０重
量部、ウレタン／ニトロセルロース樹脂を１０〜２０重
量部、ポリアミド／ニトロセルロース樹脂を１０〜３０
重量部、アクリル／アルキッド／ニトロセルロース樹脂
を２〜１０重量部含有してなることを特徴としている。That is, the sterilization indicator composition of the present invention comprises 100 parts by weight of a disperse dye C.I. I disperse thread 58, C.I. I disperse thread 110, C.I. I
Disperse Red 137, C.I. One or more dyes selected from I Disperse Violet 43 in an amount of 0.05 to 3
Parts by weight, 0.1-5 parts by weight of organic acid, 5-18 parts by weight of bismuth compound, 1-10 parts by weight of sulfur or sulfur compound, 10-20 parts by weight of urethane / nitrocellulose resin, polyamide / nitrocellulose 10-30 resin
It is characterized by containing 2 to 10 parts by weight of an acrylic / alkyd / nitrocellulose resin.
【０００９】ビスマス化合物と硫黄もしくは硫黄化合物
はＡＣ滅菌により変色する成分であり、ポリアミド／ニ
トロセルロース樹脂は変色反応を調整し、且つインキ化
した際のインキの安定性の向上を図る。A bismuth compound and sulfur or a sulfur compound are components that change color by AC sterilization, and a polyamide / nitrocellulose resin adjusts the color change reaction and improves the stability of the ink when formed into an ink.
【００１０】Ｃ．Ｉディスパースレッド５８、Ｃ．Ｉデ
ィスパースレッド１１０、Ｃ．Ｉディスパースレッド１
３７、Ｃ．Ｉディスパースバイオレッド４３と有機酸と
ウレタン／ニトロセルロース樹脂とアクリル／アルキッ
ド／ニトロセルロース樹脂はＥＯＧ滅菌、ＰＳ滅菌、ホ
ルマリン滅菌により変色する成分であり、且つ、ウレタ
ン／ニトロセルロース樹脂とアクリル／アルキッド／ニ
トロセルロース樹脂は、変色反応を調整しインキ化した
際のインキの安定性の向上を図る。C. I disperse thread 58, C.I. I disperse thread 110, C.I. I Disperse Red 1
37, C.I. I Disperse Violet 43, organic acid, urethane / nitrocellulose resin, and acrylic / alkyd / nitrocellulose resin are components that change color by EOG sterilization, PS sterilization, and formalin sterilization, and are urethane / nitrocellulose resin and acrylic / alkyd. The nitrocellulose resin controls the discoloration reaction and improves the stability of the ink when it is formed into an ink.
【００１１】ビスマス化合物の適切な含有量は組成物総
重量の５〜１８重量部、好ましくは１１〜１４重量部で
ある。５重量部以下ではＡＣ滅菌しても変色せず、１８
重量部以上だとＥＯＧ滅菌、ＰＳ滅菌、ホルマリン滅菌
における反応を阻害し変色しなくさせる。A suitable content of the bismuth compound is 5 to 18 parts by weight, preferably 11 to 14 parts by weight based on the total weight of the composition. When the amount is less than 5 parts by weight, the color does not change even after AC sterilization.
If the amount is more than the weight part, the reaction in EOG sterilization, PS sterilization, and formalin sterilization is inhibited and discoloration is prevented.
【００１２】硫黄もしくは硫黄化合物の適切な含有量は
組成物総量の１〜１０重量部、好ましくは２〜６重量部
である。１重量部以下では変色がわかりにくく、１０重
量部以上では、変色した際インジケータ組成物に接触す
る他の被滅菌物を汚染する恐れがある。A suitable content of sulfur or sulfur compound is 1 to 10 parts by weight, preferably 2 to 6 parts by weight of the total composition. If the amount is less than 1 part by weight, the discoloration is difficult to understand, and if the amount is more than 10 parts by weight, there is a possibility that other objects to be sterilized that come into contact with the indicator composition when stained may be contaminated.
【００１３】ポリアミド／ニトロセルロース樹脂の適切
な含有量は組成物総量の１０〜３０重量部、好ましくは
１２〜１５重量部である。１０重量部以下ではＡＣ滅菌
処理の際、低条件下でも変色してしまい、３０重量部以
上だと、ＡＣ滅菌以外の滅菌法の反応に影響を及ぼし変
色を阻害し、変色しなくさせる。A suitable content of the polyamide / nitrocellulose resin is 10 to 30 parts by weight, preferably 12 to 15 parts by weight of the total composition. If the amount is less than 10 parts by weight, discoloration will occur even under low conditions during AC sterilization treatment. If the amount is more than 30 parts by weight, it will affect the reaction of sterilization methods other than AC sterilization, disturb the discoloration and prevent discoloration.
【００１４】上記した分散染料と有機酸とウレタン／ニ
トロセルロース樹脂とアクリル／アルキッド／ニトロセ
ルロース樹脂は、ＥＯＧ滅菌、ＰＳ滅菌、ホルマリン滅
菌処理により変色する成分であり、ウレタン／ニトロセ
ルロース樹脂とアクリル／アルキッド／ニトロセルロー
ス樹脂は、変色調整成分でもある。The above-mentioned disperse dye, organic acid, urethane / nitrocellulose resin, and acrylic / alkyd / nitrocellulose resin are components that change their color by EOG sterilization, PS sterilization, and formalin sterilization. The alkyd / nitrocellulose resin is also a discoloration controlling component.
【００１５】分散染料の適切な含有量は組成物総量の
０．０５〜３重量部、好ましくは０．１５〜０．５重量
部である。含有量が０．０５重量部以下では変色の有無
の確認が困難であり、３重量部以上になるとＡＣ滅菌に
おける変色を阻害し変色しなくさせるという問題を生じ
る。A suitable content of the disperse dye is 0.05 to 3 parts by weight, preferably 0.15 to 0.5 part by weight, based on the total amount of the composition. If the content is 0.05 parts by weight or less, it is difficult to confirm the presence or absence of discoloration. If the content is 3 parts by weight or more, discoloration in AC sterilization is inhibited and discoloration does not occur.
【００１６】有機酸の適切な含有量は組成物総量の０．
１〜５重量部、好ましくは０．４〜２重量部である。
０．１重量部以下ではＥＯＧ滅菌、ＰＳ滅菌、ホルマリ
ン滅菌処理後の変色が小さく不鮮明であり、５重量部以
上になると印刷時の塗膜の着色力が濃くなりすぎ、滅菌
処理後の変色が判別し難くなる。An appropriate content of the organic acid is 0.1% of the total amount of the composition.
It is 1 to 5 parts by weight, preferably 0.4 to 2 parts by weight.
If the amount is less than 0.1 part by weight, the discoloration after EOG sterilization, PS sterilization, and formalin sterilization is small and unclear. If the amount is more than 5 parts by weight, the coloring power of the coating film during printing becomes too deep, and the discoloration after the sterilization treatment is reduced. It becomes difficult to determine.
【００１７】ウレタン／ニトロセルロース樹脂とアクリ
ル／アルキッド／ニトロセルロース樹脂の適切な含有量
は組成物総量に対して前者が１０〜２０重量部、好まし
くは１３〜１６重量部、後者が２〜１５重量部、好まし
くは４〜７重量部である。ウレタン／ニトロセルロース
樹脂とアルキッド／アクリル樹脂の含有量が少なすぎる
と、ＥＯＧ滅菌、ＰＳ滅菌、ホルマリン滅菌処理後の変
色が薄く判別し難くなり、多く含有するとＡＣ滅菌用、
ＡＣ滅菌処理した際インジケータが変色しなくなる。Suitable contents of the urethane / nitrocellulose resin and the acrylic / alkyd / nitrocellulose resin are 10 to 20 parts by weight, preferably 13 to 16 parts by weight, and 2 to 15 parts by weight, based on the total amount of the composition. Parts, preferably 4 to 7 parts by weight. If the contents of the urethane / nitrocellulose resin and the alkyd / acrylic resin are too small, the discoloration after EOG sterilization, PS sterilization, and formalin sterilization becomes thin and difficult to distinguish.
The indicator does not change color after AC sterilization.
【００１８】本発明のインジケータ組成物は、上記した
成分をボールミル、サンドミル等の分散機を用いて混練
しインキ化することによって得られる。The indicator composition of the present invention can be obtained by kneading the above-mentioned components using a disperser such as a ball mill or a sand mill to form an ink.
【００１９】本発明の滅菌インジケータ組成物には上記
成分以外に、他の有色顔料や体質顔料を加えてもよい。
例えばシリカ、炭酸カルシウム、二酸化チタン、タル
ク、炭酸マグネシウム、硫酸バリウム、ステアリン酸カ
ルシウム、ファーストイエロー、クロムイエロー、フタ
ロシアニンブルー、フタロシアニングリーン等を添加す
れば、インキ状態での保存安定性が図れ変色性の向上が
図れる。[0019] In addition to the above components, other colored pigments and extenders may be added to the sterilization indicator composition of the present invention.
For example, if silica, calcium carbonate, titanium dioxide, talc, magnesium carbonate, barium sulfate, calcium stearate, fast yellow, chrome yellow, phthalocyanine blue, phthalocyanine green, etc. are added, storage stability in the ink state can be achieved and discoloration can be improved. Can be achieved.
【００２０】このようにして得られたインジケータイン
キ組成物は、紙やプラスチックフィルムのような基材に
印刷して、検知カード、検知テープとしたり、被滅菌物
の包装材に直接印刷したりして使用する。The indicator ink composition thus obtained is printed on a base material such as paper or plastic film to be used as a detection card or a detection tape, or directly printed on a packaging material of an object to be sterilized. To use.
【００２１】なお本発明に用いるインキ用樹脂として
は、本発明に使用する樹脂を含有している市販のインキ
用メジウムを使用することは何ら差し支えない。As the ink resin used in the present invention, a commercially available ink medium containing the resin used in the present invention may be used at all.
【００２２】[0022]
【実施例】次に本発明の滅菌インジケータ組成物につい
てその特徴とするところを実施例を挙げて説明する。Next, the characteristics of the sterilization indicator composition of the present invention will be described with reference to examples.
【００２３】[0023]
【実施例１】 酸化ビスマス １２重量部 タルク ３重量部 硫黄 ３重量部 Ｃ・Ｉディスパースレッド５８ ０．３重量部 サリチル酸 ０．６重量部 フタロシアニングリーン ０．１重量部 チタン白 ２重量部 ＦＢＨＤメジウム（東洋インキ製） ３５重量部 ＦＢキングＸメジウム（東洋インキ製） １１重量部 アクリル／アルキッド／ニトロセルロース樹脂 ６重量部 酢酸エチル ８重量部 イソプロピルアルコール １５重量部 上記の配合物をボールミルで約５０時間混練し赤桃色の
インキを得た。このインキを上質紙に印刷した印刷物は
ＡＣ滅菌（条件１２１℃−１５分）で茶黒色に変色し
た。また同一印刷物をＥＯＧ滅菌（条件ＥＯ ２０％、
ＣＯ２ ８０％混合ガス、ガス圧１ｋｇ／ｃｍ２、温度
５０℃、相対湿度５０％ＲＨ−２時間）で薄青色に変色
した。また同一インキをタイベックに印刷した印刷物は
ＰＳ滅菌（ＳＴＥＲＲＡＤ−１００：ジョンソン・エン
ド・ジョンソンメディカル（株）低温プラズマ滅菌シス
テム）７５分間処理で緑色に変色した。また同一印刷物
をホルマリン滅菌（条件ホルマリンガス濃度５％、温度
６０℃、１０時間）でうすい緑色に変色した。Example 1 Bismuth oxide 12 parts by weight Talc 3 parts by weight Sulfur 3 parts by weight CI disperse red 58 0.3 parts by weight Salicylic acid 0.6 parts by weight Phthalocyanine green 0.1 parts by weight Titanium white 2 parts by weight FBHD medium ( 35 parts by weight FB King X Medium (manufactured by Toyo Ink) 11 parts by weight Acrylic / alkyd / nitrocellulose resin 6 parts by weight Ethyl acetate 8 parts by weight isopropyl alcohol 15 parts by weight Kneading the above composition for about 50 hours with a ball mill A red-pink ink was obtained. The printed matter obtained by printing this ink on high-quality paper was discolored to brownish black by AC sterilization (conditions: 121 ° C. for 15 minutes). In addition, the same printed matter is EOG sterilized (condition EO 20%,
The color changed to light blue under a mixed gas of 80% CO 2, a gas pressure of 1 kg / cm 2 , a temperature of 50 ° C, and a relative humidity of 50% RH for 2 hours. The printed matter obtained by printing the same ink on Tyvek was turned green by a PS sterilization (STERRAD-100: Johnson & Johnson Medical Co., Ltd. low-temperature plasma sterilization system) for 75 minutes. Further, the same printed matter was discolored to pale green by formalin sterilization (condition: formalin gas concentration: 5%, temperature: 60 ° C., 10 hours).
【００２４】[0024]
【実施例２】 酸化ビスマス １２重量部 タルク ３重量部 硫黄 ３重量部 Ｃ・Ｉディスパースレッド１３７ ０．４重量部 安息香酸亜鉛 ０．４重量部 フタロシアニングリーン ０．１重量部 チタン白 ２．１重量部 ＦＢＨＤメジウム（東洋インキ製） ３５重量部 ＭＰメジウム（Ｔ＆Ｋ ＴＯＫＡ製） ２０重量部 酢酸エチル ５重量部 エチルアルコール ５重量部 酢酸プロピル １０重量部 酢酸ブチル ４重量部 上記の配合物をボールミルで約５０時間混練し赤桃色の
インキを得た。このインキを上質紙に印刷した印刷物は
実施例１と同じ条件のＡＣ滅菌で茶黒色に変色した。ま
た同一印刷物を実施例１と同一条件でＥＯＧ滅菌したと
ころうすい青色に変色した。また同一インキをタイベッ
クに印刷した印刷物は実施例１と同一条件のＰＳ滅菌で
はうすい緑青色に変色した。また同一印刷物を実施例１
と同一条件でホルマリン滅菌したところうすい緑色に変
色した。Example 2 Bismuth oxide 12 parts by weight Talc 3 parts by weight Sulfur 3 parts by weight CI disperse red 137 0.4 parts by weight Zinc benzoate 0.4 parts by weight Phthalocyanine green 0.1 parts by weight Titanium white 2.1 parts by weight Parts FBHD medium (manufactured by Toyo Ink) 35 parts by weight MP medium (manufactured by T & K TOKA) 20 parts by weight ethyl acetate 5 parts by weight ethyl alcohol 5 parts by weight propyl acetate 10 parts by weight butyl acetate 4 parts by weight The mixture was kneaded for a time to obtain a red-pink ink. The printed matter obtained by printing this ink on high quality paper turned brown and black by AC sterilization under the same conditions as in Example 1. Further, when the same printed matter was subjected to EOG sterilization under the same conditions as in Example 1, the color changed to light blue. Further, the printed matter obtained by printing the same ink on Tyvek was discolored to a light green-blue color by PS sterilization under the same conditions as in Example 1. Example 1
When sterilized with formalin under the same conditions as above, the color changed to pale green.
【００２５】[0025]
【比較例１】実施例１の配合うち、Ｃ・Ｉディスパース
レッド５８とＦＢキングＸメジウムを除いた配合物をボ
ールミルで約５０時間混練し赤桃色のインキを得た。こ
のインキを上質紙に印刷した印刷物は実施例１のＡＣ滅
菌と同一条件で滅菌処置した結果、茶黒色に変色した。
またこの同一印刷物とタイベックに印刷した印刷物を実
施例１と同一条件でＥＯＧ滅菌、ＰＳ滅菌、ホルマリン
滅菌したところ変色は認められなかった。Comparative Example 1 Among the formulations of Example 1, the formulation excluding CI Disperse Red 58 and FB King X Medium was kneaded with a ball mill for about 50 hours to obtain a red-pink ink. Printed matter obtained by printing this ink on high-quality paper was sterilized under the same conditions as in the AC sterilization of Example 1, and as a result, the color was changed to brown.
When the same printed matter and the printed matter printed on Tyvek were subjected to EOG sterilization, PS sterilization, and formalin sterilization under the same conditions as in Example 1, no discoloration was observed.
【００２６】[0026]
【比較例２】実施例２の配合のうち、酸化ビスマスとＦ
ＢＨＤメジウムを除いた配合物をボールミルで約５０時
間混練し赤色のインキを得た。このインキを上質紙に印
刷した印刷物を実施例１と同一条件でＡＣ滅菌したとこ
ろ変色は認められなかった。また同一印刷物とタイベッ
クに印刷した印刷物を実施例１と同一条件でＥＯＧ滅
菌、ＰＳ滅菌、ホルマリン滅菌処理したところ、ＥＯＧ
滅菌では青色に、ＰＳ滅菌で薄い青緑色に、ホルマリン
滅菌で薄い緑色に変色した。COMPARATIVE EXAMPLE 2 Bismuth oxide and F
The composition excluding the BHD medium was kneaded with a ball mill for about 50 hours to obtain a red ink. When a printed matter obtained by printing this ink on high quality paper was subjected to AC sterilization under the same conditions as in Example 1, no discoloration was observed. The same printed matter and the printed matter printed on Tyvek were subjected to EOG sterilization, PS sterilization, and formalin sterilization treatment under the same conditions as in Example 1.
The color changed to blue in sterilization, pale blue-green in PS sterilization, and pale green in formalin sterilization.
【００２７】[0027]
【発明の効果】以上、本発明の滅菌インジケータ組成物
は医療分野におけるＡＣ滅菌、ＥＯＧ滅菌、ＰＳ滅菌、
ホルマリン滅菌の各滅菌条件に整合した変色性を具備し
ている。被滅菌物と本発明の組成物を用いたインジケー
タを一緒に滅菌した後、インジケータの変色を確認する
ことにより被滅菌物の滅菌完了の良否を容易に検知でき
る。従来のように滅菌方法に応じたインジケータを選択
する必要がなく誤使用が回避される。また滅菌方法に応
じた複数のインジケータを必要としないので、滅菌資材
を製造する側、使用する側の何れも在庫管理の簡略化と
製造・購入コストの低減が図れる。As described above, the sterilization indicator composition of the present invention can be used for AC sterilization, EOG sterilization, PS sterilization,
It has discoloration that matches the sterilization conditions of formalin sterilization. After the object to be sterilized and the indicator using the composition of the present invention are sterilized together, the quality of the sterilization of the object to be sterilized can be easily detected by confirming the discoloration of the indicator. It is not necessary to select an indicator according to the sterilization method as in the related art, and erroneous use is avoided. Further, since a plurality of indicators according to the sterilization method are not required, both the side that manufactures and uses the sterilized material can simplify the inventory management and reduce the manufacturing / purchase cost.
Claims (2)
ノ基、Ｒ２は水素基、メトキシ基、エトキシ基、Ｒ３，
Ｒ４，Ｒ５は水素基、水酸基、硝酸基、アルキル基〕。
有機酸、ビスマス化合物、硫黄もしくは硫黄化合物、ウ
レタン／ニトロセルロース樹脂、ポリアミド／ニトロセ
ルロース樹脂、アクリル／アルキッド／ニトロセルロー
ス樹脂を必須成分とする滅菌インジケータ組成物。1. A disperse dye represented by the following general formula: [Wherein R1 is a hydrogen group, a methyl group, an ethyl group, an acylamino group, R2 is a hydrogen group, a methoxy group, an ethoxy group, R3
R4 and R5 are a hydrogen group, a hydroxyl group, a nitric acid group and an alkyl group].
A sterilization indicator composition comprising an organic acid, a bismuth compound, sulfur or a sulfur compound, a urethane / nitrocellulose resin, a polyamide / nitrocellulose resin, and an acrylic / alkyd / nitrocellulose resin as essential components.
８、Ｃ．Ｉディスパースレッド１１０、Ｃ．Ｉディスパ
ースレッド１３７、Ｃ．Ｉディスパースバイオレッド４
３の中から１種以上を含有することを特徴とする、請求
項１記載の滅菌インジケータ組成物。2. The method according to claim 1, wherein the disperse dye is C.I. I Disperse Red 5
8, C.I. I disperse thread 110, C.I. I Disperse Red 137, C.I. I Disperse Violet 4
3. The sterilization indicator composition according to claim 1, wherein the composition comprises at least one of the three components.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001167425A JP2002323451A (en) | 2001-04-26 | 2001-04-26 | Sterilization indicator composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001167425A JP2002323451A (en) | 2001-04-26 | 2001-04-26 | Sterilization indicator composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2002323451A true JP2002323451A (en) | 2002-11-08 |
Family
ID=19009809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001167425A Pending JP2002323451A (en) | 2001-04-26 | 2001-04-26 | Sterilization indicator composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2002323451A (en) |
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